Relevant bibliographies by topics / Quassinoids

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Quassinoids'

Author: Grafiati
Published: 4 June 2021
Last updated: 31 January 2023

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Journal articles on the topic "Quassinoids"

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Yang, Wei-Qun, Wei Tang, Xiao-Jun Huang, Jian-Guo Song, Yue-Yue Li, Yu Xiong, Chun-Lin Fan, Zhen-Long Wu, Ying Wang, and Wen-Cai Ye. "Quassinoids from the Roots of Eurycoma longifolia and Their Anti-Proliferation Activities." Molecules 26, no. 19 (September 30, 2021): 5939. http://dx.doi.org/10.3390/molecules26195939.

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A phytochemical investigation on the roots of medicinal plant Eurycoma longifolia resulted in the isolation of 10 new highly oxygenated C20 quassinoids longifolactones G‒P (1–10), along with four known ones (11–14). Their chemical structures and absolute configurations were unambiguously elucidated on the basis of comprehensive spectroscopic analysis and X-ray crystallographic data. Notably, compound 1 is a rare pentacyclic C20 quassinoid featuring a densely functionalized 2,5-dioxatricyclo[5.2.2.04,8]undecane core. Compound 4 represents the first example of quassinoids containing a 14,15-epoxy functionality, and 7 features an unusual α-oriented hydroxyl group at C-14. All isolated compounds were evaluated for their anti-proliferation activities on human leukemia cells. Among the isolates, compounds 5, 12, 13, and 14 potently inhibited the in vitro proliferation of K562 and HL-60 cells with IC50 values ranging from 2.90 to 8.20 μM.
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Darvesh, Sultan, Andrew S. Grant, David I. MaGee, and Zdenek Valenta. "Synthetic studies towards bruceantin. Part 2. The synthesis of a pentacyclic intermediate." Canadian Journal of Chemistry 69, no. 4 (April 1, 1991): 723–31. http://dx.doi.org/10.1139/v91-107.

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In a synthetic approach to the quassinoid bruceantin (2), the key intermediate 8 obtained via alkylation of a dianion has been transformed into the pentacyclic intermediate 33 via an ABDC ring forming strategy. The key steps involved in this route are as follows: a unique acid catalyzed cyclization, 19 → 20; an intramolecular Michael reaction, 24 → 28; and an allyl sulfoxide [2,3]-sigmatropic rearrangement to introduce the axial C12 alcohol, 31 → 33. Key words: bruceantin, quassinoids, cyclization, sulfoxides, sigmatropic rearrangement.
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Knetzger, Nicola, Viktoria Bachtin, Susanne Lehmann, Andreas Hensel, Eva Liebau, and Fabian Herrmann. "The Anthelmintic Quassinoids Ailanthone and Bruceine a Induce Infertility in the Model Organism Caenorhabditis elegans by an Apoptosis-like Mechanism Induced in Gonadal and Spermathecal Tissues." Molecules 26, no. 23 (December 3, 2021): 7354. http://dx.doi.org/10.3390/molecules26237354.

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In continuation of the search for new anthelmintic natural products, the study at hand investigated the nematicidal effects of the two naturally occurring quassinoids ailanthone and bruceine A against the reproductive system of the model nematode Caenorhabditis elegans to pinpoint their anthelmintic mode of action by the application of various microscopic techniques. Differential Interference Contrast (DIC) and the epifluorescence microscopy experiments used in the presented study indicated the genotoxic effects of the tested quassinoids (c ailanthone = 50 µM, c bruceine A = 100 µM) against the nuclei of the investigated gonadal and spermathecal tissues, leaving other morphological key features such as enterocytes or body wall muscle cells unimpaired. In order to gain nanoscopic insight into the morphology of the gonads as well as the considerably smaller spermathecae of C. elegans, an innovative protocol of polyethylene glycol embedding, ultra-sectioning, acridine orange staining, tissue identification by epifluorescence, and subsequent AFM-based ultrastructural data acquisition was applied. This sequence allowed the facile and fast assessment of the impact of quassinoid treatment not only on the gonadal but also on the considerably smaller spermathecal tissues of C. elegans. These first-time ultrastructural investigations on C. elegans gonads and spermathecae by AFM led to the identification of specific quassinoid-induced alterations to the nuclei of the reproductive tissues (e.g., highly condensed chromatin, impaired nuclear membrane morphology, as well as altered nucleolus morphology), altogether implying an apoptosis-like effect of ailanthone and bruceine A on the reproductive tissues of C. elegans.
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Darvesh, Sultan, Andrew S. Grant, David I. MaGee, and Zdenek Valenta. "Synthetic studies towards bruceantin. Part 1. Establishment of the carbon network." Canadian Journal of Chemistry 69, no. 4 (April 1, 1991): 712–22. http://dx.doi.org/10.1139/v91-902.

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In a synthetic approach to the biologically active quassinoid bruceantin 1, intermediate 47 was prepared, which contains all required C-atoms, rings A and B, and four of the 10 chiral centers of bruceantin. The possibilities for a convergent strategy were explored, in which a 5-carbon unit would be joined to a 15-carbon unit by three bonds. After the study of various alkylations and Michael additions needed for the key step, it was found that 3-iodo-1-trimethylsilyl-5-hexenyne44adds to the dianion of methyl ketone nitriles 3 and 13 cheme-, diastereo-, and enantioselectively.Key words: bruceantin, quassinoids, alkylation, Michael addition.
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Cachet, N., F. Hoakwie, S. Bertani, G. Bourdy, E. Deharo, D. Stien, E. Houel, et al. "Antimalarial Activity of Simalikalactone E, a New Quassinoid from Quassia amara L. (Simaroubaceae)." Antimicrobial Agents and Chemotherapy 53, no. 10 (October 2009): 4393–98. http://dx.doi.org/10.1128/aac.00951-09.

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ABSTRACT We report the isolation and identification of a new quassinoid named simalikalactone E (SkE), extracted from a widely used Amazonian antimalarial remedy made out of Quassia amara L. (Simaroubaceae) leaves. This new molecule inhibited the growth of Plasmodium falciparum cultured in vitro by 50%, in the concentration range from 24 to 68 nM, independently of the strain sensitivity to chloroquine. We also showed that this compound was able to decrease gametocytemia with a 50% inhibitory concentration sevenfold lower than that of primaquine. SkE was found to be less toxic than simalikalactone D (SkD), another antimalarial quassinoid from Q. amara, and its cytotoxicity on mammalian cells was dependent on the cell line, displaying a good selectivity index when tested on nontumorogenic cells. In vivo, SkE inhibited murine malaria growth of Plasmodium vinckei petteri by 50% at 1 and 0.5 mg/kg of body weight/day, by the oral or intraperitoneal routes, respectively. The contribution of quassinoids as a source of antimalarial molecules needs therefore to be reconsidered.
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Elkhateeb, Ahmed, Masahiro Yamasaki, Yoshimitsu Maede, Ken Katakura, Kensuke Nabeta, and Hideyuki Matsuura. "Anti-babesial Quassinoids from the Fruits of Brucea Javanica." Natural Product Communications 3, no. 2 (February 2008): 1934578X0800300. http://dx.doi.org/10.1177/1934578x0800300207.

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The medicinal plant Brucea javanica (L.) Merr. (Simaroubaceae), grown in China, was examined for anti-babesial properties. The anti-babesial activity of the fruit was found to be attributed to its quassinoid constituents. Ten active compounds were isolated and purified from a chloroform extract. The identities of these compounds were confirmed from NMR spectroscopic and mass spectral data as brusatol (1), bruceantin (2), bruceine A (3), bruceantinol (4), dehydrobruceine B (5), dehydrobrusatol (6), dehydrobruceine A (7), bruceine D (8), bruceoside A (9), and yadanzioside G (10). When tested in vitro against Babesia gibsoni, compounds 1–10 had IC50 values of 0.74, 13.4, 4.0, 12.0, 308.2, 10.5, 835.0, >1000, and >1000 ng/mL, respectively. Compounds 1–4, 6 and 7 had far higher activity than the commercial anti-babesial drug diminazene aceturate, which possesses an IC50 value of 70.5 ng/mL. Except for bruceine A (3), bruceantinol (4) and bruceine D (8), this is the first report of the anti-babesial activity of these isolated quassinoids.
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Insanu M, Pratiwi S N E, and Fidrianny I. "A review of the phytochemical compounds and pharmacological activities of Eurycoma longifolia." International Journal of Research in Pharmaceutical Sciences 12, no. 2 (May 24, 2021): 1462–70. http://dx.doi.org/10.26452/ijrps.v12i2.4716.

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Eurycoma longifolia belongs to Simaroubaceae family. It is a tall tree and has different local name from many countries and this review consisted of their traditional usage, phytochemical compounds and pharmacological activity. A systematic review was conducted to study the scientific work of E. longifolia which published in the last 10 years and minimum 20 articles that published in the last 2 years, published in Pubmed, Scopus etc. also has a digital object identifier (DOI). E. longifolia was a popular traditional medicine. The leaves wasused as supplement for giving birth, its bark as anthelmintic and its roots as antimalaria, laxative, antidiabetic etc.Due to high demand of this plant there are various formula of E. longifolia available in health food market. Many studies have been performed to determine the active constituents and pharmacology activities of E. longifolia. Alkaloid, quassinoid, polyphenols, flavonoid, polysaccharide, triterpenoid were found in E. longifolia. Quassinoids is a major phytochemical compound in E. longifolia which has various types like eurycumanone, eurycomanol, eurycomadilactone and eurylactone. Quassinoids has bitter taste and often found in Simaroubaceae family.Pharmacological activities of E. longifolia such as anti-inflammatory, analgesic, antioxidant, antimicrobial, antidiabetic, anti-osteoporotic activities. The literature review results showed that E. longifolia can be considered as medicinal plant for human. In the future, further studies on mechanism of pharmacology activity of E. longifolia are warranted.
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Miyake, Katsunori, Yasuhiro Tezuka, Suresh Awale, Feng Li, and Shigetoshi Kadota. "Quassinoids fromEurycoma longifolia." Journal of Natural Products 72, no. 12 (December 28, 2009): 2135–40. http://dx.doi.org/10.1021/np900486f.

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Mendez, Belmari, Jeyshka Reyes, Isabel Conde, Zulma Ramos, Eunice Lozada, Ailed M. Cruz, Gabriela Asencio, et al. "Simalikalactone D, a Potential Anticancer Compound from Simarouba tulae, an Endemic Plant of Puerto Rico." Plants 9, no. 1 (January 11, 2020): 93. http://dx.doi.org/10.3390/plants9010093.

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Species of the genus Simarouba have been studied because of their antimalarial and antileukemic activities. A group of oxygenated terpenes called quassinoids have been isolated from species of the Simarouba genus, and are responsible for its therapeutic properties. We hypothesized that Simarouba tulae, an endemic plant from Puerto Rico, is a natural source rich in quassinoid compounds with anticancer activity. The leaves were processed and extracted with solvents of different polarities. The extracts were screened for their antiproliferative activity, and it was shown that the chloroform extract was the most active extract. This extract was purified using different chromatographic techniques to afford the quassinoid simalikalactone D (SKD). This compound was further characterized using NMR and X-ray diffraction analysis. A reassessment of original structural assignments for SKD is proposed. SKD showed high cytotoxicity activity, with an IC50 of 55, 58, and 65 nM in A2780CP20 (ovarian), MDA-MB-435 (breast), and MDA-MB-231 (breast) cell lines, respectively. Exposure to SKD led to 15% inhibition of the migration of MDA-MB-231 cells.
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Hiwatari, Mitsuteru, Jingqiu Dai, Wei Liu, Yu-Dong Zhou, Dale G. Nagle, and Stephan W. Morris. "Cytotoxicity Assessment of Quassinoids Neosergeolide and Isobrucein B toward Hematopoietic and Solid Malignancies Identifies STAT3 Activation To Be Predictive of Antitumor Response." Blood 110, no. 11 (November 16, 2007): 1394. http://dx.doi.org/10.1182/blood.v110.11.1394.1394.

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Abstract Quassinoids are natural product compounds known to possess tumor cytotoxicity and antimalarial activity. Neosergiolide and isobrucein B are two quassinoids previously isolated from roots and stems of Picrolemma sprucei. In screening studies to identify inhibitors that target STAT3, we discovered neosergeolide and isobrucein B as active compounds. Approximately 5000 plant-derived extracts were screened using a cell line that stably expresses a STAT3-dependent luciferase reporter and NPM-ALK, which constitutively induces STAT3 transcriptional activity. Of 25 total hits, a P. sprucei extract was potent and selective for STAT3 inhibition, and bioassay-guided isolation identified neosergeolide and isobrucein B as the inhibitory compounds. Western blot analysis confirmed that neosergeolide and isobrucein B not only inhibit the tyrosine phosphorylation and activation of STAT3 but also decrease total STAT3 protein levels via a mechanism due in part to enhanced proteasome-mediated degradation. Small-molecule proteasome inhibitors such as MG132 and ALLN reversed the ability of the two quassinoids to decrease STAT3 protein levels; furthermore, simultaneous incubation of various hematopoietic malignancy cell lines with either neosergeolide or isobrucein B and MG132 or ALLN antagonized the cytotoxic activity of the quassinoids. Assessment of neosergiolide and isobrucein B antitumor effects using an XTT assay revealed both compounds to possess potent cytotoxic activity across a broad spectrum of hematopoietic malignancies, with T-leukemias/lymphomas being especially responsive. For example, mycosis fungoides (MF)- and Sezary syndrome (SS)-derived cell lines, as well as non-MF/SS cutaneous T-cell lymphoma (CTCL) lines, were potently inhibited by both quassinoids (neosergiolide IC50 values: MAC-1, 11.6 nM; MAC-2A, 6.9 nM; Hut-78, 6.6 nM; HH, 4.3 nM; MJ, 7.0 nM; isobrucein B IC50 values: MAC-1, 31.9 nM; MAC-2A, 72.3 nM; Hut-78, 23.5 nM; HH; 20.3 nM; MJ, 13.5 nM). Non-hematopoietic cell lines representing various solid tumors also exhibited potent cytotoxic responses to the quassinoids (e.g., gastric carcinoma line AGS [neosergiolide IC50: 16.9 nM; isobrucein B IC50: 114.9 nM]). With rare exceptions, the cytotoxicity of the quassinoids against a specific tumor cell line correlated with STAT3 activation status; for example, breast cancer line MCF7 with inactive STAT3 was resistant to both quassinoids even at the maximum concentration tested (6.25 μM), whereas breast cancer lines MDA-MB-468 and MDA-MB-435s with activated STAT3 were inhibited by both compounds at low concentrations (neosergiolide IC50: MDA-MB-435s, 31.3 nM; MDA-MB-468, 29.9 nM; isobrucein B IC50: MDA-MB-435s, 209.3 nM; MDA-MB-468, 356.8 nM). The in vitro antitumor activity of the two quassinoids could also be demonstrated in vivo. For example, isobrucein B (1.0 mg/kg IP once q 3d x 5 doses) could be safely administered and potently inhibited the growth in SCID mice of the CD30+ primary CTCL MAC-1 cell line; mice at treatment day 16 showed average subcutaneous tumor volumes of 3839 ± 863 (s.e.) mm3 in the vehicle-control group and 913 ± 349 (s.e.) mm3 in the isobrucein B group (P=0.008, t-test). These results provide strong support for STAT3 targeting in antitumor drug discovery and suggest that quassinoids may have utility in such an approach.
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Dissertations / Theses on the topic "Quassinoids"

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Carvalho, Josà Ivan Ximenes de. "Estudo fitoquÃmico e avaliaÃÃo do potencial de inibiÃÃo da enzima acetilcolisnesterase de Simarouba versicolor (SIMAROUBACEAE)." Universidade Federal do CearÃ, 2008. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=4712.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior
O presente trabalho descreve o estudo quÃmico e farmacolÃgico da casca do caule da espÃcie Simarouba versicolor, pertencente à famÃlia Simaroubaceae. A espÃcie ocorre preferencialmente em Ãreas abertas de solos bem drenados, como cerrados e caatinga. Conhecida popularmente como âpau paraÃbaâ, âmata-cachorroâ ou âsimaruba do Brasilâ, a casca do seu caule possui propriedades inseticida e antihelmÃntica. Com o objetivo de estabelecer uma possÃvel relaÃÃo extrato atividade de inibiÃÃo da enzima acetilcolinesterase (AChE). Foi realizada uma triagem dos extratos das partes (folhas, talos, Galhos, Casca do caule e Cerne) da espÃcie Simarouba versicolor, atravÃs do ensaio de Ellman. O extrato etanÃlico da casca do caule apresentou elevada inibiÃÃo da AChE, desse extrato, as fraÃÃes clorofÃrmica e acetato de etila foram identificadas como sendo responsÃveis pela inibiÃÃo da enzima. A prospecÃÃo quÃmica da fraÃÃo clorofÃrmica resultou no isolamento de trÃs compostos, uma mistura de esterÃides β- sitosterol e estigmasterol, um quassinÃide, a 11-acetilamarolida e o alcalÃide 4,5- dimetÃxicantin-6-ona. Na fraÃÃo acetato de etila foi isolado o 3-β-O-β-D-glicopiranosil sistosterol. A determinaÃÃo estrutural desses compostos foi realizada atravÃs de anÃlise espectroscÃpica pelos mÃtodos de IV, EM, RMN1H e 13C-BB utilizando tÃcnicas uni e bidimensionais e por comparaÃÃo com dados descritos na literatura. Na anÃlise qualitativa de inibiÃÃo AChE os extratos e os constituintes isolados 11-acetilamarolida e 4,5-dimetÃxicantin-6-ona apresentaram bons resultados. Os extratos tambÃm apresentaram atividade citotÃxica em trÃs linhagens tumorais testados.
The present paper describes the chemical and pharmacological study of the stem bark of the species Simarouba versicolor, which belongs to the family Simaroubaceae. The species are found, mainly in open areas of well drained soils such as cerrado and caatinga. Known popularly as âpau Paraibaâ, âmata-cachorroâ or âBrazilian simarubaâ, the bark of its trunk has insecticidal and antihelminthic properties. It aims to establish a possible extract inhibition of enzyme activity of acetyl cholinesterase (AChE) Relationship. It was accomplished a triage of the parts extracts (leaves, stems, branches, stem bark and heartwood) of the species Simarouba Versicolor by the Ellman test. The ethanol extract of stem bark showed high inhibition of AChE, from this extract, the chloroform fraction and ethyl acetate were identified as being responsible for the inhibition of the enzyme. The chemical prospect of the chloroform fraction resulted in the isolation of three compounds, a mixture of steroid β-sitosterol and stigma sterol, a quassinoid, the 11-acetylamarolide and the alkaloid 4.5-dimetoxicantin-6-one. In the ethyl acetate fraction it was isolated the 3-β-O-β-D-glucopyranosyl sitosterol. The Structure determination of these compounds was performed by spectroscopic analysis through the methods of IR, MS, RMN1H and 13C-BB using uni and bidimensional techniques and by comparison with the data reported in the literature. In qualitative analysis of the AChE inhibition the extracts and isolated constituents 11- acetylamarolide and 4.5-dimetoxicantin-6-one showed good results. The extracts also showed cytotoxic activity in three tumor lines tested.
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Yang, Dexi. "Studies Toward Syntheses of Chaparrinone and Polyandrane." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1218634343.

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Yu, Li. "Tau-Path Test - A Nonparametric Test For Testing Unspecified Subpopulation Monotone Association." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1255657068.

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Donahue, Matthew G. "Studies toward the synthesis of the C₁₉ quassinoid polyandrane." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1127227359.

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Thesis (Ph. D.)--Ohio State University, 2005.
Title from first page of PDF file. Document formatted into pages; contains xxiii, 454 p.; also includes graphics (some col.). Includes bibliographical references (p. 246-259). Available online via OhioLINK's ETD Center
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Cwynar, Valerie A. "Studies toward the synthesis of the C₁₉ quassinoid polyandrane." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1168377607.

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Donahue, Matthew G. "Studies toward the synthesis of the C19 quassinoid polyandrane." The Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1127227359.

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Cwynar, Valerie. "Studies toward the synthesis of the C19 quassinoid polyandrane." The Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=osu1168377607.

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Whaley, C. "The intramolecular Diels-Alder reaction of allene carboxylates and cationic approaches to quassinoid skeleton." Thesis, University of Manchester, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383897.

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BOUMAIZA, LOTFI. "Ceto c-glycosides , insatures, synthese et application a la preparation de precurseurs chiraux des quassinoides." Paris 7, 1992. http://www.theses.fr/1992PA077227.

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Les quassinoides sont une importante classe de produits antitumoraux dont la structure se caracterise par l'existence d'un noyau naphtopyranne qui posent un probleme de synthese difficile en raison de la presence d'un carbone quaternaire a la jonction des trois cycles. J'ai demontre qu'il etait possible de creer ce noyau par une reaction de diels-alder intramoleculaire. Cette reaction, est le premier exemple d'une reaction de diels-alder intramoleculaire dans le cas d'une cetone substituee. La realisation de cette cyclisation necessitait de disposer d'une part d'une methodologie qui rend possible la preparation des composes possedant une double liaison trisubstituee sur le cycle pyranne et, d'autre part d'un procede d'introduction d'une dienone sur la chaine exocyclique. Aucune reaction connue ne permettant de preparer ce type de molecules, j'ai resolu ce probleme: a) en mettant au point les premieres methodes de preparation des 2-ceto c-glycosides insatures par une reaction de condensation d'olefines et d'ethers allyliques sur les 2-hydroxy glycals et, b) en demontrant que dans le cas des c-glycosides il y avait addition selective du methyle lithium sur le carbonyle insature. Au cours de ce travail j'ai pu montrer que la condensation des glycals avec les ethers allyliques s'effectuait par un mecanisme de transposition 1,2. En outre la preparation de l'aglycone par des methodes classiques ne donnant pas de resultats satisfaisants j'ai mis au point un nouveau procede general de synthese des dienones ee et ez par la condensation d'un enolate de lithium avec un aldehyde insature en presence de trimethylchlorosilane. Finalement a partir du ceto c-glycoside ainsi prepare, j'ai pu demontrer qu'il etait possible d'introduire, en une seule etape, l'ensemble des centres asymetriques des cycles bcd desquassinoides avec une complete stereoselectivite
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Thibault, Carl. "Développement d'une nouvelle méthodologie pour la construction de quassinoïdes utilisant des vinylallènes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0016/MQ56977.pdf.

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Book chapters on the topic "Quassinoids"

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Seigler, David S. "Limonoids, Quassinoids, and Related Compounds." In Plant Secondary Metabolism, 473–85. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-4913-0_25.

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Houël, Emeline, Didier Stien, Geneviève Bourdy, and Eric Deharo. "Quassinoids: Anticancer and Antimalarial Activities." In Natural Products, 3775–802. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-22144-6_161.

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Chakraborty, Dipjyoti, and Amita Pal. "Quassinoids: Chemistry and Novel Detection Techniques." In Natural Products, 3345–66. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-22144-6_144.

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Pengelly, Andrew. "Triterpenoids and saponins." In The constituents of medicinal plants, 95–111. 3rd ed. Wallingford: CABI, 2021. http://dx.doi.org/10.1079/9781789243079.0006.

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Abstract This chapter focuses on the various classes of triterpenoids (free triterpenes, triterpenoid saponins, steroidal saponins, cardiac glycosides, phytosterols, phytoecdysteroids, curcurbitacins and quassinoids), which occur in the free state within plants or as aglycones of glycosides. Information on the chemical structures and pharmacological actions of these triterpenoids and saponins are also presented.
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Roberts, M. F. "Ailanthus altissima (the Tree of Heaven): In Vitro Culture and the Formation of Alkaloids and Quassinoids." In Biotechnology in Agriculture and Forestry, 39–57. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-84071-5_3.

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Polonsky, Judith. "Quassinoid Bitter Principles II." In Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products, 221–64. Vienna: Springer Vienna, 1985. http://dx.doi.org/10.1007/978-3-7091-8790-6_4.

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Okano, M., N. Fukamiya, and K. H. Lee. "Bioactive quassinoids." In Bioactive natural Products (Part D), 285–333. Elsevier, 2000. http://dx.doi.org/10.1016/s1572-5995(00)80132-5.

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Ganem, Bruce. "Synthetic Studies on Pentacyclic Quassinoids." In Strategies and Tactics in Organic Synthesis, 121–63. Elsevier, 1991. http://dx.doi.org/10.1016/b978-0-08-092430-4.50010-x.

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Curcino Vieira, Ivo J., and Raimundo Braz-Filho. "Quassinoids: Structural Diversity, Biological Activity and Synthetic Studies." In Studies in Natural Products Chemistry, 433–92. Elsevier, 2006. http://dx.doi.org/10.1016/s1572-5995(06)80032-3.

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Guo, Zhengming, Suryanarayana Vangapandu, Robert D. Sindelar, and Larry A. Walker. "Biologically Active Quassinoids and Their Chemistry: Potential Leads for Drug Design." In Frontiers in Medicinal Chemistry - (Volume 4), 285–308. BENTHAM SCIENCE PUBLISHERS, 2012. http://dx.doi.org/10.2174/978160805207310904010285.

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Conference papers on the topic "Quassinoids"

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Lahrita, L., R. Hirosawa, E. Kato, and J. Kawabata. "Eurycoma longifolia Jack and Its Quassinoids Stimulate Lipolysis in 3T3-L1 Adipocytes." In GA 2017 – Book of Abstracts. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1608048.

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Sarbini, S., M. N. Nayan, W. W. D. Chik, M. M. N. Radzi, R. Akbar, and S. A. Jusoh. "Molecular docking studies of a quassinoid and P-glycoprotein." In 2013 IEEE Symposium on Computers & Informatics (ISCI). IEEE, 2013. http://dx.doi.org/10.1109/isci.2013.6612391.

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