Academic literature on the topic 'Quaternary amino acids'

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Journal articles on the topic "Quaternary amino acids"

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Jørgensen, K., S. Cabrera, E. Reyes, J. Alemán, A. Milelli та S. Kobbelgaard. "Quaternary α-Amino Acids and Derivatives". Synfacts 2008, № 11 (2008): 1220. http://dx.doi.org/10.1055/s-0028-1083383.

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Haugen, J. E., H. P. Sejrup, and N. B. Vogt. "Chemotaxonomy of Quaternary benthic foraminifera using amino acids." Journal of Foraminiferal Research 19, no. 1 (1989): 38–51. http://dx.doi.org/10.2113/gsjfr.19.1.38.

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Szponar, A., and L. Szajdak. "Amino acids in Quaternary soil horizons from southwest Poland." European Journal of Soil Science 54, no. 2 (2003): 237–42. http://dx.doi.org/10.1046/j.1365-2389.2003.00536.x.

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Hano, Tadashi, Takaaki Ohtake, Michiaki Matsumoto, Daihachi Kitayama, Fumiaki Hori, and Fumiyuki Nakashio. "Extraction equilibria of amino acids with quaternary ammonium salt." JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 24, no. 1 (1991): 20–24. http://dx.doi.org/10.1252/jcej.24.20.

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Jiang, Shende, Guang Yang, Shuanglin Qin та ін. "An Efficient Method for Constructing Cyclic β-Amino Acids Bearing Quaternary Stereocenters". Synlett 30, № 05 (2019): 593–99. http://dx.doi.org/10.1055/s-0037-1611718.

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This paper describes an efficient method for constructing cyclic β-amino acids bearing quaternary stereocenters. NaHMDS-promoted asymmetric α-alkylation was employed to obtain the key intermediates with quaternary stereogenic centers, which were subsequently reduced by NaBH4 in 10% methanol in THF, with high yields and high diastereoselectivities. By removing the allyl ester group and the chiral auxiliary, the corresponding cyclic β-amino acid hydrochlorides were finally obtained.
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Picard, Audrey, Stephane Ciblat та Yeeman K. Ramtohul. "Synthesis of α,α-Disubstituted Benzocyclobutane Amino Acids through [2+2] Annulation of Benzyne with Dehydroalanine". Synlett 31, № 05 (2020): 507–11. http://dx.doi.org/10.1055/s-0039-1691572.

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A mild and general method for the synthesis of α,α-disubstituted benzocyclobutane amino acids through a [2+2] annulation of benzyne with dehydroalanine is described. Yields up to 88% of the constrained quaternary amino acids can be obtained and its application in peptidomimetic synthesis is demonstrated.
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Davies, Stephen G., A. Christopher Garner, Jaqueline V. A. Ouzman та ін. "Diastereoselective synthesis of quaternary α-amino acids from diketopiperazine templates". Org. Biomol. Chem. 5, № 13 (2007): 2138–47. http://dx.doi.org/10.1039/b704475e.

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Gómez, José Enrique, Wusheng Guo, Silvia Gaspa та Arjan W. Kleij. "Copper-Catalyzed Synthesis of γ-Amino Acids Featuring Quaternary Stereocenters". Angewandte Chemie International Edition 56, № 47 (2017): 15035–38. http://dx.doi.org/10.1002/anie.201709511.

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Mata, Lara, Alberto Avenoza, Jesús H. Busto, Francisco Corzana та Jesús M. Peregrina. "Quaternary Chiral β2,2-Amino Acids with Pyridinium and Imidazolium Substituents". Chemistry - A European Journal 18, № 49 (2012): 15822–30. http://dx.doi.org/10.1002/chem.201202096.

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Gómez, José Enrique, Wusheng Guo, Silvia Gaspa та Arjan W. Kleij. "Copper-Catalyzed Synthesis of γ-Amino Acids Featuring Quaternary Stereocenters". Angewandte Chemie 129, № 47 (2017): 15231–34. http://dx.doi.org/10.1002/ange.201709511.

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Dissertations / Theses on the topic "Quaternary amino acids"

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Mambrini, Antonin. "Couplage oxydant d'énolates et chimie microfluidique : deux nouvelles approches pour la synthèse énantiosélective d'acides α-aminés quaternaires par Mémoire de Chiralité". Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS456/document.

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Les acides α-aminés quaternaires permettent l’accès à des structures et dérivés peptidiques présentant des propriétés biologiques intéressantes. De nombreuses voies de synthèses asymétriques sont décrites dans la littérature. La voie de synthèse la plus utilisée est l’alkylation d’acides α-aminés tertiaires. Dans les versions énantioselectives décrites, peu utilisent la chiralité initiale des acides α-aminés tertiaires comme inducteurs de chiralité. La mémoire de chiralité est un des principes permettant l’accès à des acides α-aminés quaternaires énantioenrichis avec, comme unique source de ch
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Bigelow, Jeffrey. "Quaternary Amino Acid Geochronology of the Lahontan Basin, Nevada, and the Chewaucan Basin, Oregon." DigitalCommons@USU, 1998. https://digitalcommons.usu.edu/etd/3587.

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Amino acid geochronology based on fossil molluscs provides a useful approach to determining the Quaternary history of Great Basin lakes. The Lahontan basin, Nevada, and the Chewaucan basin, Oregon, in the northwest corner of the Great Basin, both contained lakes during the Quaternary. The aim of this study is to improve the Quaternary geochronology in these two basins by measuring time-dependent changes in amino acids preserved in fossil molluscan shells. The abundance of D-alloisoleucine relative to Lisoleucine (All) characterizes the extent of racemization, which increases with age and Ul fo
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New, Evan M. "Aminochronology and Time-averaging of Quaternary Land Snail Assemblages from Colluvial Soils in the Madeira Archipelago." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin153538137669338.

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Murray-Wallace, Colin Vincent. "Evaluation and application of the amino acid racemisation reaction in studies of quaternary coastal and marine sediments in Australia /." Title page, contents and abstract only, 1987. http://web4.library.adelaide.edu.au/theses/09PH/09phm9848.pdf.

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Evans, Genevieve Laura. "Disrupting the quaternary structure of DHDPS as a new approach to antibiotic design." Thesis, University of Canterbury. Biological Sciences, 2010. http://hdl.handle.net/10092/4469.

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This thesis examined the enzyme dihydrodipicolinate synthase (DHDPS, E.C. 4.2.1.52) from the pathogen Mycobacterium tuberculosis. DHDPS is a validated antibiotic target for which no potent inhibitor based on substrates, intermediates or product has been found. The importance of the homotetrameric quaternary structure in E. coli DHDPS has been demonstrated by the 100-fold decrease in activity observed in a dimeric variant, DHDPS-L197Y, created by site-directed mutagenesis. This suggested a new approach for inhibitor design: targeting the dimer-dimer interface and disrupting tetramer formation.
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Tiong, Erica. "Stereoselective formation of all carbon quaternary centers: synthesis of alpha,alpha-disubstituted beta-amino carbonyl compounds via the Mannich reaction and total synthesis of (-)-puraquinonic acid." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104585.

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A bicyclic thioglycolate lactam chiral auxiliary was previously developed in our group for the asymmetric formation of quaternary carbon stereocenters via enolate alkylation. This method is notable for the stereocontrolled generation of alpha, alpha-disubstituted amide enolates, without reliance on the steric differences of the alpha-substituents. Coupled with excellent facial discrimination in electrophilic approach, this led to a general and practical method for enantioselective preparation of quaternary carbon centers via alkylation reactions. This thesis describes the extension of this met
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Afewerki, Samson. "Development of catalytic enantioselective C-C bond-forming and cascade transformations by merging homogeneous or heterogeneous transition metal catalysis with asymmetric aminocatalysis." Doctoral thesis, Mittuniversitetet, Avdelningen för naturvetenskap, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-23605.

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Chiral molecules play a central role in our daily life and in nature, for instance the different enantiomers or diastereomers of a chiral molecule may show completely different biological activity. For this reason, it is a vital goal for synthetic chemists to design selective and efficient methodologies that allow the synthesis of the desired enantiomer. In this context, it is highly important that the concept of green chemistry is considered while designing new approaches that eventually will provide more environmental and sustainable chemical synthesis.The aim of this thesis is to develop th
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Barbour, Wood Susan L. "Quantitative Ecological and Taphonomic Patterns in Late Cenozoic Mollusk-Dominated Marine Fossil Assemblages." Diss., Virginia Tech, 2006. http://hdl.handle.net/10919/27710.

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Applications in paleontological research are far from being limited to taxonomic collection and identification. Nor is such research limited to working solely on fossil data. Actualistic paleontology is the study of modern or recent organisms and processes to better understand those of the past. The bulk of this body of research falls under the category of actualistic paleontology, and examines geochronological methods and error biases in dating biological specimens ranging in age from modern to thousands of years old. Although such methods are arguably not perfect, error rates of ± a few
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Dietz, Friedrich Rainer [Verfasser]. "Stereoselective synthesis of quaternary α-amino-acids [alpha-amino-acids] using chemo- and biocatalysts = Stereoselektive Synthesen von quartären α-Aminosäuren [Alpha-Aminosäuren] unter Verwendung von Chemo- und Biokatalysatoren / vorgelegt von Friedrich Rainer Dietz". 2010. http://d-nb.info/1009673645/34.

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Fiset, Dominic. "Hydrolyse assistée par micro-ondes : synthèse de cystéines a-substituées sur échelle multi-grammes; Synthèse catalytique énantiosélective d’alkylidènecyclopropanes 1,1-di-accepteurs." Thèse, 2012. http://hdl.handle.net/1866/9652.

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Le présent mémoire est subdivisé en deux principaux sujets. Le premier porte sur le développement d’une hydrolyse de thiazolidines assistée par micro-ondes en vue d’obtenir des cystéines a-substituées. Le second est axé sur le développement d’une méthodologie pour la synthèse catalytique énantiosélective d’alkylidènecyclopropanes 1,1-di-accepteurs. Dans un premier temps, les rôles et les utilités des acides aminés quaternaires, plus spécifiquement des cystéines a-substituées, seront abordés, puis une revue des différentes méthodes énantiosélectives pour accéder à ces unités sera effectuée. Par
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Books on the topic "Quaternary amino acids"

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Columb, Malachy O. Local anaesthetic agents. Edited by Michel M. R. F. Struys. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199642045.003.0017.

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Local anaesthetic agents cause a pharmacologically induced reversible neuropathy characterized by axonal conduction blockade. They act by blocking the sodium ionophore and exhibit membrane stabilizing activity by inhibiting initiation and propagation of action potentials. They are weak bases consisting of three components: a lipophilic aromatic ring, a link, and a hydrophilic amine. The chemical link classifies them as esters or amides. Local anaesthetics diffuse through the axolemma as unionized free-base and block the ionophore in the quaternary ammonium ionized form. The speed of onset of b
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Freund, Holger, and Deutsche Quartärvereinigung e. V, eds. E&G – Quaternary Science Journal Vol. 59 No 1-2. Geozon Science Media, 2011.

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Book chapters on the topic "Quaternary amino acids"

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Wehmiller, John F. "Amino Acid Racemization: Applications in Chemical Taxonomy and Chronostratigraphy of Quaternary Fossils." In Skeletal Biomineralization: Patterns, Processes and Evolutionary Trends. American Geophysical Union, 2013. http://dx.doi.org/10.1029/sc005p0287.

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Inagaki, Shinsuke, and Toshimasa Toyo’oka. "Amino Acid Analysis via LC–MS Method After Derivatization with Quaternary Phosphonium." In Methods in Molecular Biology. Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-445-2_5.

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Wehmiller, John F. "Amino Acid Racemization: Applications in Chemical Taxonomy and Chronostratigraphy of Quaternary Fossils." In Skeletal Biomineralization: Patterns, Processes and Evolutionary Trends. Springer US, 1991. http://dx.doi.org/10.1007/978-1-4899-5740-5_25.

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Zhang, Shao-Wu, Wei Chen, Chun-Hui Zhao, Yong-Mei Cheng, and Quan Pan. "Predicting Protein Quaternary Structure with Multi-scale Energy of Amino Acid Factor Solution Scores and Their Combination." In Lecture Notes in Computer Science. Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-77413-6_9.

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Taber, Douglass. "Enantioselective Assembly of Aminated Stereogenic Centers." In Organic Synthesis. Oxford University Press, 2011. http://dx.doi.org/10.1093/oso/9780199764549.003.0033.

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Although natural amino acids are readily available, there is a continuing need for unnatural amino acids. Jon C. Antilla of the University of South Florida has described (J. Am. Chem. Soc. 2007, 129, 5830) a promising approach, based on the enantioselective organocatalytic reduction of imines such as 1 derived from α-keto esters. The aryl group is easily removed to give the primary amine. Mukund P. Sibi of North Dakota State University has developed (J. Am. Chem. Soc. 2007, 129, 4522) an enantioselective Mg catalyst that mediated the addition of benzyl hydrazine 6 to imides such as 5. The initial adduct cyclized to the pyrazolidinone 7. Karl Anker Jørgensen of Aarhus University has reported (Angew. Chem. Int. Ed. 2007, 46, 1983) a complementary protocol for the enantioselective conjugate addition of a nitrogen nucleophile. Enantioselective homologation can also be a powerful approach. Benjamin List of the Max-Planck-Institute, Mülheim has found (Angew. Chem. Int. Ed. 2007, 46, 612; Organic Lett. 2007, 9, 1149) that three-component coupling of acetyl cyanide, an aldehyde and benzylamine under the influence of the Jacobsen thiourea catalyst 10 delivered the onecarbon homologated nitrile 12 in high ee. Other homologation methods are also effective. Li Deng of Brandeis University has shown (Organic Lett. 2007, 9, 603) that under the influence of cinchona-derived quaternary salts, malonates will add to racemic amido sulfones such as 13 to give the β-amino malonate 14 in high ee. Fujie Tanaka and Carlos F. Barbas III of Scripps/La Jolla have found (Angew. Chem. Int. Ed. 2007, 46, 1878) that the simple organocatalyst proline will mediate the aza-Baylis Hillman addition of an unsaturated aldehyde such as 15 to 16 in high ee. The alkene 17 is the kinetic product. On prolonged exposure to the reaction conditions, 17 was equilibrated to the more stable 18 . Ming-Hua Xu and Guo-Qiang Lin of the Shanghai Institute of Organic Chemistry have established (J. Am. Chem. Soc. 2007, 129, 5336) a robust protocol for the enantioselective assembly of -arylated benzylamines such as 21.
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Taber, Douglass F. "Enantioselective Preparation of Alcohols and Amines: The Lam Synthesis of (+)-Tanikolide." In Organic Synthesis. Oxford University Press, 2013. http://dx.doi.org/10.1093/oso/9780199965724.003.0038.

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Takashi Ooi of Nagoya University effected (J. Am. Chem. Soc. 2010, 132, 12240) the enantioselective protonation of ketene silyl acetals such as 1 to give 2 in high ee. Hyeon-Kyu Lee of the Korean Research Institute of Chemical Technology achieved (Org. Lett. 2010, 12, 4184) high ee in the hydrogenation of the cyclic sulfamidate 3 to 4. Doo Ok Jang of Yonsei University combined (J. Am. Chem. Soc. 2010, 132, 12168) the nucleophilic allyl indium with a protonated chiral amine to effect homologation of 5 to 6. Ryo Shintani and Tamio Hayashi of Kyoto University reported (Org. Lett. 2010, 12, 4106) a related advance with tetraarylborates. Kazuaki Ishihara, also of Nagoya University (Org. Lett. 2010, 12, 3502) and Yoshihiro Sohtome and Kazuo Nagasawa of the Tokyo University of Agriculture and Technology (Angew. Chem. Int. Ed. 2010, 49, 9254) devised conditions for adding malonate to imines such as 7. Professors Shintani and Hayashi also employed (J. Am. Chem. Soc. 2010, 132, 13168) tetraarylborates to convert 9 to the α-quaternary amine 10. Professor Ooi (Angew. Chem. Int. Ed. 2010, 49, 5567) and Wanbin Zhang of Shanghai Jiao Tong University (J. Am. Chem. Soc. 2010, 132, 15939) prepared α-quaternary amino acids such as 12 by nucleophilic rearrangement of 11. Keiji Maruoka, also of Kyoto University, reported (J. Am. Chem. Soc. 2010, 132, 17074; not illustrated) a catalytic enantioselective conjugate addition approach to α-quaternary amines. Shuji Akai of the University of Shizuoka converted (Org. Lett. 2010, 12, 4900) the racemic allylic alcohol 13 to the enantiomerically enriched acetate 14 by combining V-catalyzed equilibration with lipase-catalyzed acylation. Toshiro Harada of the Kyoto Institute of Technology added (Org. Lett. 2010, 12, 5270) the alkenylboron 16 to the aldehyde 15 with high ee. Xiang Zhou of Wuhan University and Lin Pu of the University of Virginia significantly improved (Tetrahedron Lett . 2010, 51, 5024) a protocol for the enantioselective addition of aliphatic alkynes to aliphatic aldehydes. For other enantioselective additions to aldehydes (not illustrated), see J. Org. Chem. 2010, 75 , 5326 and Org. Lett. 2010, 12, 5088.
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Miller, G. H., D. S. Kaufman, and S. J. Clarke. "AMINO ACID DATING." In Encyclopedia of Quaternary Science. Elsevier, 2013. http://dx.doi.org/10.1016/b978-0-444-53643-3.00054-6.

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Miller, G. H., and S. J. Clarke. "AMINO-ACID DATING." In Encyclopedia of Quaternary Science. Elsevier, 2007. http://dx.doi.org/10.1016/b0-44-452747-8/00059-4.

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MILLER, G., and S. CLARKE. "AMINO-ACID DATING." In Encyclopedia of Quaternary Science. Elsevier, 2007. http://dx.doi.org/10.1016/b0-444-52747-8/00059-4.

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Taber, Douglass F. "Enantioselective Synthesis of Alcohols and Amines: The Fujii/Ohno Synthesis of (+)-Lysergic Acid." In Organic Synthesis. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780190200794.003.0035.

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Ramón Gómez Arrayás and Juan C. Carretero of the Universidad Autónoma de Madrid effected (Chem. Commun. 2011, 47, 6701) enantioselective conjugate borylation of an unsaturated sulfone 1, leading to the alcohol 2. Robert E. Gawley of the University of Arkansas found (J. Am. Chem. Soc. 2011, 133, 19680) conditions for enantioselective ketone reduction that were selective enough to distinguish between the ethyl and propyl groups of 3 to give 4. Vicente Gotor of the Universidad de Oviedo used (Angew. Chem. Int. Ed. 2011, 50, 8387) an overexpressed Baeyer-Villiger monoxygenase to prepare 6 by dynamic kinetic resolution of 5. Li Deng of Brandeis University prepared (J. Am. Chem. Soc. 2011, 133, 12458) 8 in high ee by kinetic enantioselective migration of the alkene of racemic 7. Bernhard Breit of the Freiburg Institute for Advanced Studies established (J. Am. Chem. Soc. 2011, 133, 20746) the oxygenated quaternary center of 10 by the addition of benzoic acid to the allene 9. Keith R. Fandrick of Boehringer Ingelheim constructed (J. Am. Chem. Soc. 2011, 133, 10332) the oxygenated quaternary center of 13 by enantioselective addition of the propargylic nucleophile 12 to 11. Yian Shi of Colorado State University devised (J. Am. Chem. Soc. 2011, 133, 12914) conditions for the enantioselective transamination of the α-keto ester 14 to the amine 15. Professor Deng added (Adv. Synth. Catal. 2011, 353, 3123) 18 to an enone 17 to give the protected amine 19. Song Ye of the Institute of Chemistry, Beijing effected (J. Am. Chem. Soc. 2011, 133, 15894) elimination/addition of an unsaturated acid chloride 20 to give the γ-amino acid derivative 22. Frank Glorius of the Universität Münster added (Angew. Chem. Int. Ed. 2011, 50, 1410) an aldehyde 23 to 24 to give the amide 25. Sentaro Okamoto of Kanagawa University designed (J. Org. Chem. 2011, 76, 6678) an organocatalyst for the enantioselective Steglich rearrangement of 26, creating the aminated quaternary center of 27. Most impressive of all was the report (Org. Lett. 2011, 13, 5460) by Hélène Lebel of the Université de Montréal of the direct enantioselective C–H amination of 28 to give 29.
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Conference papers on the topic "Quaternary amino acids"

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Vallribera, Adelina, Marcial Morena-Manas, Elisenda Trepat, and Rosa Sebastian. "Asymmetric Synthesis of Quaternary a-Amino Acids Using D-Ribonolactone Acetonide as a Chiral Auxiliary." In The 3rd International Electronic Conference on Synthetic Organic Chemistry. MDPI, 1999. http://dx.doi.org/10.3390/ecsoc-3-01717.

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Xiao, Xuan, and Pu Wang. "Prediction of Protein Quaternary Structural Type with Functional Domain and Pseudo Amino Acid Composition." In 2009 3rd International Conference on Bioinformatics and Biomedical Engineering (iCBBE). IEEE, 2009. http://dx.doi.org/10.1109/icbbe.2009.5163214.

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Keasler, Vic, Brian Bennett, and Heather McGinley. "Analysis of Bacterial Kill Versus Corrosion From Use of Common Oilfield Biocides." In 2010 8th International Pipeline Conference. ASMEDC, 2010. http://dx.doi.org/10.1115/ipc2010-31593.

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Bacterial proliferation is a severe problem in many oilfield systems, especially in aging systems with high water cuts. Depending on the types of microorganisms present, they can cause microbiologically influenced corrosion (MIC) or biofouling of filters, membranes, and metal surfaces. Common oilfield bacteria include sulfate-reducing bacteria (SRB) that can generate hydrogen sulfide (H2S) and iron sulfide (FeS) as a by-product (iron sulfide can occur in different structural forms), acid producing bacteria that can secrete organic acids that lower the pH within the microenvironment of a biofil
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Barnes, M. J., C. M. Fitzsimmons, and L. F. Morton. "THE STRUCTURE OF PLATELET-REACTIVE SITES IN COLLAGENS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643588.

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Collagen-induced platelet aggregation is an essential step in haemostasis and may be important in thrombosis, particularly that associated with the atherosclerotic plaque. We have located platelet-binding sites in collagen by fragmentation of the molecule with cyanogen bromide (CB) and measurement of the platelet aggregatory activity of the fragments following their renaturation to restore triple-helical configuration and polymerisation to introduce quaternary structure. We have found a high1y-reactive site in collagen type III located in the peptide α1(III)CB4 which was active at a concentrat
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Reports on the topic "Quaternary amino acids"

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Andrews, J. T. Amino Acid Stratigraphy [Chapter 3: Quaternary Geology of the Canadian Shield]. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1989. http://dx.doi.org/10.4095/127967.

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