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Dissertations / Theses on the topic 'Quercetin'

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Published: 4 June 2021
Last updated: 25 July 2025

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1

Camargo, Mariana Santoro de. "Efeito da quercetina sobre alguns fatores relacionados com a virulência de Staphylococcus aureus /." Araraquara : [s.n.], 2008. http://hdl.handle.net/11449/94814.

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Orientador: Maria Stella Gonçalves Raddi<br>Banca: Mariza Landgraf<br>Banca: Karina Ferrazzoli Devienne<br>Resumo: Esse estudo foi realizado com o objetivo de avaliar o efeito da concentração subinibitória de quercetina sobre alguns fatores relacionados à virulência de Staphylococcus aureus (ATCC 25923). A atividade antibacteriana foi determinada através do método de microdiluição em caldo e a concentração de 40μg/mL de quercetina foi utilizada como sub-inibitória. O sobrenadante de culturas de S. aureus em BHI contendo quercetina diminuiu a atividade hemolítica para hemácias de carneiro mas n
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2

Alves, Nelson Mendes. "Atenuação da radionecrose em ratos Wistar com aplicação cutânea de quercetina." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-18032016-093140/.

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O aumento da incidência de câncer tem sido expressivo nas ultimas décadas na população mundial, sendo confirmada segundo previsões de entidades nacionais e internacionais da área da saúde. O surgimento do câncer é influenciado predominantemente por fatores genéticos e ambientais, sendo manifestado com mais intensidade na população adulta. As principais modalidades para tratamento do câncer (radioterapia, quimioterapia e cirurgia) podem ser usadas individualmente ou em combinação, dependendo do tipo de câncer. Entre as modalidades citadas, a radioterapia é aquela com maior abrangência no tratam
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3

Lopes, Bruno Rafael Pereira [UNESP]. "Avaliação da atividade anti-hRSV da quercetina e seus derivados acetilados." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/138577.

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Submitted by BRUNO RAFAEL PEREIRA LOPES null (brunorpl@hotmail.com) on 2016-05-11T19:53:59Z No. of bitstreams: 1 Dissertação versão repositório.pdf: 7264895 bytes, checksum: 0ac82b804ba7471cb20cb92afa6c4d3f (MD5)<br>Rejected by Felipe Augusto Arakaki (arakaki@reitoria.unesp.br), reason: Solicitamos que realize uma nova submissão seguindo as orientações abaixo: O arquivo submetido está sem a folha de aprovações providenciada pela Pós-graduação. Lembramos que a versão submetida por você é considerada a versão final da dissertação/tese, portanto não poderá ocorrer qualquer alteração em seu c
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4

Lopes, Bruno Rafael Pereira. "Avaliação da atividade anti-hRSV da quercetina e seus derivados acetilados /." Assis, 2016. http://hdl.handle.net/11449/138577.

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Orientadora: Karina Alves de Toledo<br>Banca: Valéria Marta Gomes do Nascimento<br>Banca: Fátima Pereira de Souza<br>Resumo: No mundo, estima-se que exista cerca de 12 milhões de casos graves e 3 milhões de casos muito graves de infecção do trato respiratório inferior em crianças anualmente. Dentre os agentes etiológicos destas infecções, o vírus sincicial respiratório humano (hRSV) é a principal causa de internações infantis em países desenvolvidos, agravando os casos de bronquiolite, pneumonia e infecções pulmonares obstrutivas crônicas em pessoas de todas as idades, principalmente crianças
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5

Gaeta, Henrique Hessel. "Avaliação de compostos polifenólicos nos efeitos induzidos pela sPLA2 de veneno cortálico e botrópico." Universidade Estadual Paulista (UNESP), 2018. http://hdl.handle.net/11449/153495.

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Submitted by Henrique Hessel Gaeta null (henriquehg@gmail.com) on 2018-04-10T18:24:06Z No. of bitstreams: 1 GaetaHH_TESEvF.pdf: 14579852 bytes, checksum: 747f9ee69906717d6131a1a1b8429cd4 (MD5)<br>Rejected by Disleide Silvia Valerio Gounella null (disleide@clp.unesp.br), reason: Boa tarde. Fazer as seguintes modificações e inclusões: - O título do arquivo tem que estar com o mesmo nome do título do trabalho defendido; - Acertar o nome do Orientador que está repetido; - Modificar a área de pesquisa, pois a citada não existe no programa de pós-graduação; - Incluir a área de conhecimento.
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6

Behm, Norma. "Einfluss des Flavonols Quercetin auf ausgewählte Parameter des Energiestoffwechsels bei fettreich ernährten Ratten." Tönning Lübeck Marburg Der Andere Verl, 2009. http://d-nb.info/997031263/04.

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7

Freitas, Thiago Carrazoni de. "Caracterização da atividade entomotóxica induzida pelo extrato metanólico de araucaria angustifolia em baratas da espécie phoetalia pallida." Universidade Federal do Pampa, 2012. http://dspace.unipampa.edu.br:8080/jspui/handle/riu/3862.

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Submitted by Francine Silva (francine.silva@unipampa.edu.br) on 2019-03-26T18:42:20Z No. of bitstreams: 1 Caracterização da atividade entomotóxica induzida pelo extrato metanólico de araucaria angustifolia em baratas da espécie phoetalia pallida.pdf: 1288498 bytes, checksum: 743a39a2337c5be31393482af81a2fb6 (MD5)<br>Made available in DSpace on 2019-03-26T18:42:21Z (GMT). No. of bitstreams: 1 Caracterização da atividade entomotóxica induzida pelo extrato metanólico de araucaria angustifolia em baratas da espécie phoetalia pallida.pdf: 1288498 bytes, checksum: 743a39a2337c5be31393482af81a2fb6 (M
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8

Souza, Alex Jardelino Felizardo de. "Avaliação dos efeitos antimicrobianos de rutina e quercetina in vitro." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314773.

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Orientador: Marcos Hikari Toyama<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-13T09:30:32Z (GMT). No. of bitstreams: 1 Souza_AlexJardelinoFelizardode_M.pdf: 1467336 bytes, checksum: 55dd95e96aceb5b58d0dc8fa2e11820e (MD5) Previous issue date: 2009<br>Resumo: Flavonóides é um grupo de compostos polifenólicos e metabólitos secundários produzidos por plantas. Eles podem ser encontrados em frutos e vegetais. Vários estudos têm mostrado que os flavonóides podem apresentar várias atividades biológicas importantes como ag
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9

Reinboth, Marianne. "Bioverfügbarkeit des Flavonols Quercetin beim Hund." Doctoral thesis, Universitätsbibliothek Leipzig, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-62483.

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6 Zusammenfassung Marianne Reinboth Bioverfügbarkeit des Flavonols Quercetin beim Hund Veterinär-Physiologisches Institut der Veterinärmedizinischen Fakultät der Universität Leipzig Eingereicht im Juni 2010 79 Seiten, 20 Abbildungen, 6 Tabellen, 211 Literaturangaben, 1 Anhang Schlüsselwörter: Quercetin, Bioverfügbarkeit, Hund, absolute Bioverfügbarkeit, Isoquercitrin, Rutin, Flavonole Für das pflanzliche Flavonol Quercetin werden vielfältige gesundheitsfördernde Wirkungen postuliert, so auch bei Hunden. Über die Bioverfügbarkeit des Flavonols bei dieser Spezies liegen bislang jedoch keinerlei
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10

Camargo, Mariana Santoro de [UNESP]. "Efeito da quercetina sobre alguns fatores relacionados com a virulência de Staphylococcus aureus." Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/94814.

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Made available in DSpace on 2014-06-11T19:27:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-08-15Bitstream added on 2014-06-13T20:16:31Z : No. of bitstreams: 1 camargo_ms_me_arafcf.pdf: 358942 bytes, checksum: 8f89d0a7367c210ee69a22ae462e0342 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Universidade Estadual Paulista (UNESP)<br>Esse estudo foi realizado com o objetivo de avaliar o efeito da concentração subinibitória de quercetina sobre alguns fatores relacionados à virulência de St
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11

Camargo, Camila de Andrade 1980. "Efeito da quercetina nas atividades fosfatasicas e seu efeito protetor na hepatotoxicidade induzida pelo acetaminofeno em camundongos." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314331.

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Orientadores: Hiroshi Aoyama, Marcio Andre Miranda<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-09T01:06:42Z (GMT). No. of bitstreams: 1 Camargo_CamiladeAndrade_M.pdf: 1153945 bytes, checksum: d090e6ed4e436a5029c6e36de7786df1 (MD5) Previous issue date: 2007<br>Resumo: Os flavonóides são fitocompostos polifenólicos, caracterizados quimicamente como heterosídeos flavônicos. Apresentam diversas atividades biológicas devido às suas propriedades antioxidantes e habilidades em modular a atividade de diversas enzimas ou
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12

Pujari, Twarita Anil. "Cocrystals of nutraceuticals: Protocatechuic acid and quercetin." Scholar Commons, 2009. http://scholarcommons.usf.edu/etd/2156.

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The cocrystallization of two or more pure compounds by crystal engineering to create a new functional material is of a great academic and industrial interest. Pharmaceutical cocrystallization has allured a lot of attention by means of altering the physicochemical properties of Active Pharmaceutical Ingredient (API) such as solubility, stability and bioavailability. Crystal engineering of nutraceuticals can produce novel compounds such as pharmaceutical cocrystals. To establish the importance of nutraceutical cocrystallization and its use; polyphenols, a major class of nutraceuticals and potent
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13

Cornish, Kelly Marie. "Dietary flavonoid quercetin in relation to cataract." Thesis, University of East Anglia, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247104.

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14

Hoque, Rukshana. "The effects of quercetin on iron metabolism." Thesis, King's College London (University of London), 2014. https://kclpure.kcl.ac.uk/portal/en/theses/the-effects-of-quercetin-on-iron-metabolism(c3f5d9ca-eeaf-4fa7-9878-5b04552e6367).html.

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Polyphenols are known to be major inhibitors of dietary non-haem iron bioavailability, mainly through their action as iron chelators. In this present study Caco-2 cells were used to investigate the influence of quercetin, the most abundant flavonol in the diet, on non-haem iron bioavailability using 55Fe, and the gene expression of intestinal iron transporters as measured via qPCR. Chronic exposure to quercetin (24 hours) had no significant effect on iron uptake but iron efflux was significantly decreased. Consistent with this, qPCR analysis revealed a significant decrease in basolateral trans
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15

Shi, Yuanlu. "Effects of quercetin on uric acid metabolism." Thesis, University of Leeds, 2015. http://etheses.whiterose.ac.uk/9693/.

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Background and Objective: High blood uric acid (hyperuricemia) is a common phenomenon in populations with hypertension, hyperglycemia, obesity and/or dyslipidemia. This study was to investigate the effects of quercetin supplementation on blood uric acid level and the biochemical mechanism behind it. Methods: A pilot trial confirmed the delivery of quercetin from a supplement tablet in healthy males (n=6). Randomised, double-blind, cross-over, placebo-controlled 4-week dietary intervention trial with the same supplement tablet containing 500 mg quercetin d-1 was conducted in selected healthy ma
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16

Fasolo, Daniel. "Nanoemulsões contendo quercetina e 3-0-metilquercetina : estudos de formulação e permeação cutânea." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2007. http://hdl.handle.net/10183/10872.

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A atividade antiviral de compostos polifenólicos, especialmente flavonóides, tem sido extensivamente investigada. Neste contexto, diversos estudos têm como foco o efeito da quercetina (Q) e 3-O-metilquercetina (MQ) sobre o Vírus do Herpes Simplex (HSV) uma vez que eles são importantes patógenos humanos. O objetivo deste trabalho foi o desenvolvimento de nanoemulsões de uso tópico contendo os flavonóides Q e MQ. Primeiro, nanoemulsões compostas de octildodecanol, lecitina de gema de ovo (NE), brometo de cetil trimetilamônio – CTAB – (NEC), água e Q ou MQ foram preparadas através do procedimento
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Lühring, Miriam. "Interaktionen zwischen Quercetin und Vitamin E in vivo - Untersuchungen am wachsenden Schwein." Aachen Shaker, 2009. http://d-nb.info/99369134X/04.

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18

Ameho, Clement Kojo. "The effect of quercetin as an antioxidant in vivo in rats /." Thesis, Connect to Dissertations & Theses @ Tufts University, 2004.

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Thesis (Ph.D.)--Tufts University, 2004.<br>Adviser: Jeffrey Blumberg. Submitted to the School of Nutrition Science and Policy. Includes bibliographical references. Access restricted to members of the Tufts University community. Also available via the World Wide Web;
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Hatahet, Taher. "Comparison of topical quercetin nanoformulations for skin protection." Thesis, Montpellier, 2016. http://www.theses.fr/2016MONTT219/document.

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Les flavonoïdes sont des pigments d’origine naturelle conférant leurs couleurs aux fleurs et aux fruits, identifiés dans plus de quatre milles espèces. Les flavonoïdes sont classés selon leur structure chimique de base formée par deux cycles aromatiques reliés par trois carbones : C6-C3-C6, chaîne souvent fermée en un hétérocycle oxygéné hexa- ou pentagonal. Les flavonoïdes présentent des activités physiologiques qui leurs permettent d’être utilisés comme médicaments notamment pour leur pouvoir à piéger les radicaux libres. Les activités de flavonoïdes ont fait l’objet de nombreux articles de
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20

Boots, Agnes Wilhelmina. "Health effects of quercetin: from mechanism to nutraceutical." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Universiteit Maastricht [host], 2006. http://arno.unimaas.nl/show.cgi?fid=5664.

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Ahn, Jinsoo. "Characterization of (+)-Catechin and Quercetin from Pawpaw Pulp." Ohio University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1307045912.

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Didžiulytė, Aušra. "Kvercetino ir jo glikozidų poveikis žiurkės inkstų mitochondrijų kvėpavimui." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20141014_132844-77738.

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Eksperimentinėje dalyje buvo tiriamas kvercetino ir jo glikozidų (rutino, izokvercitrino, hiperozido) poveikis žiurkės inkstų mitochondrijų oksidacinio fosforilinimo sistemai. Tyrimams naudojome Wistar veislės žiurkes. Tyrimų pobūdis – in vitro. Kvercetinas ir jo glikozidai, t.y. rutinas, hiperozidas ir izokvercitrinas (3 - 48 nM), stimuliuoja žiurkės inkstų mitochondrijų kvėpavimo greitį antroje metabolinėje būsenoje (t.y. atskiria oksidacijos ir fosforilinimo procesus). Mitochondrijų kvėpavimo greitį trečioje metabolinėje būsenoje stimuliavo kvercetinas ir rutinas, kiti flavonoidai statistiš
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Maso, Victor 1984. "Investigação dos efeitos biológicos e farmacológicos da quercetina em células de pacientes com mielodisplasia e leucemia mieloide aguda." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313062.

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Orientador: Sara Teresinha Olalla Saad<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-26T00:22:28Z (GMT). No. of bitstreams: 1 Maso_Victor_D.pdf: 2835269 bytes, checksum: f3165794df6b39b4fa01215914687cc9 (MD5) Previous issue date: 2014<br>Resumo: Síndromes mielodisplásicas (SMD) abrangem um espectro de doenças hematológicas caracterizadas por hematopoese ineficaz e risco de evolução para leucemia mielóide aguda (LMA). As leucemias agudas apresentam altas taxas de mortalidade devido, principalmente, à sua capacida
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Barcelos, Gustavo Rafael Mazzaron. "Avaliação das propriedades antigenotóxicas e antioxidantes do flavonóide quercetina e dos carotenóides bixina e norbixina contra os danos no material genético e distúrbios do estado redox causados pelo cloreto de mercúrio e metilmercúrio, in vitro e in vivo." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/60/60134/tde-26012011-092311/.

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O mercúrio (Hg) é um dos metais mais tóxicos presente no meio ambiente e o principal mecanismo relacionado à sua toxicidade é a indução do estresse oxidativo; sua forma orgânica, metilmercúrio (MeHg) é a que apresenta maior toxicidade. A exposição ao Hg ocorre principalmente através da inalação por trabalhadores ocupacionalmente expostos em diversas indústrias e/ou através do consumo de peixes e outros alimentos aquáticos contendo este metal, como por exemplo, populações amazônicas que estão expostas ao MeHg, via dieta, através do consumo de peixes contaminados. Por outro lado, é pressuposto q
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Dias, Alexandre Simões. "O antioxidante quercetina diminui o estresse oxidativo hepático em ratos diabéticos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2005. http://hdl.handle.net/10183/8174.

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Introdução: O diabetes mellitus (DM) é uma doença que apresenta elevada incidência e prevalência na população em diversas partes do mundo, e, estudos experimentais e clínicos, sugerem que o estresse oxidativo esteja envolvido na patogênese e na progressão da mesma. Objetivo: Este estudo tem como objetivo investigar os efeitos do antioxidante quercetina administrado intraperitonealmente sobre o estresse oxidativo, a ativação do fator de transcrição nuclear kappa B (NF-kB) e expressão da óxido nítrico sintase induzível (iNOS) hepática no modelo experimental de DM tipo I. Material e métodos: Fora
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Attia, Enas. "Interactions of Quercetin-Uranium Complexes with Biomembranes and DNA." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-150031.

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Uranium decontamination gains a great importance with the spread of nuclear waste in both soil and water systems across the planet. All known remediation methods of uranium can be exclusively based either on synthetic materials with high adsorbent power and known physical chemistry or life organisms by which the uranium eventually accumulated inside their tissues. In the present thesis, it was attempted to design a rational approach for uranyl removal primarily from waters using the reducing potential of quercetin, which is a plant-derived small organic molecules, along with its photochemical
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Thangasamy, Thilakavathy, Sivanandane Sittadjody, Geoffrey Mitchell, et al. "Quercetin abrogates chemoresistance in melanoma cells by modulating DeltaNp73." BioMed Central, 2010. http://hdl.handle.net/10150/610343.

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BACKGROUND:The alkylating agent Dacarbazine (DTIC) has been used in the treatment of melanoma for decades, but when used as a monotherapy for cancer only moderate response rates are achieved. Recently, the clinical use of Temozolomide (TMZ) has become the more commonly used analog of DTIC-related oral agents because of its greater bioavailability and ability to cross the blood brain barrier. The response rates achieved by TMZ are also unsatisfactory, so there is great interest in identifying compounds that could be used in combination therapy. We have previously demonstrated that the bioflavon
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Carvalho, Karine Maria Martins Bezerra. "Effect of the quercetin induced pancreatitis cerulein in mice." Universidade Federal do CearÃ, 2010. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=10495.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>Quercetin is a plant-derived flavonoid widely known by its anti-oxidant and antiinflammatory properties. Acute pancreatitis (AP) is a disease with a high morbidity and mortality and a complex pathophysiology, with variable involvement of regional tissues or organ systems. Despite of extensive investigations into this disease entity, to date there exists no specific medical treatment for AP. In this study, quercetin was investigated for its effect on the severity of cerulein-induced acute pancreatitis in mice. Male Swiss mice were t
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Otesanya, Olamide. "Influence of quercetin on asthma course in obese patients." Thesis, Сумський державний університет, 2013. http://essuir.sumdu.edu.ua/handle/123456789/32770.

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The results suggest that standard treatment in obese asthma patients lead to asthma-control in insignificant quantity of patients. Complex treatment with quercetin makes it possible to achieve asthma-control and maintain it in the majority of patients. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/32770
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COSTA, Eula Maria de Melo Barcelos. "Metabolização da quercetina e produção de quercetina 2,3-dioxigenase por Beauverias bassianas isoladas da região Centro-Oeste do Brasil." Universidade Federal de Goiás, 2009. http://repositorio.bc.ufg.br/tede/handle/tde/1554.

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Made available in DSpace on 2014-07-29T15:25:23Z (GMT). No. of bitstreams: 1 Tese_Eula_Costa.pdf: 1234220 bytes, checksum: 9b0a765b29a3c24c4ab992c52d3cab65 (MD5) Previous issue date: 2009-03-25<br>Considering the vast biotechnological applicability described for Beauveria bassiana, the versatility microbial biotransformation exhibits, the important biological activities attributed to the flavonoid quercetin, the therapeutic perspectives of its use, and the activity the enzyme quercetin 2,3-dioxygenase has on quercetin, we intended to evaluate quercetin biotransformation by B. bassiana ATCC 7
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Santos, Rosiane Freire dos. "Atividade do flavonóide quercetina em Leishmania braziliensis usando hamster como modelo de infecção." Universidade do Estado do Rio de Janeiro, 2012. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=6106.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>As leishmanioses estão entre as mais importantes endemias brasileiras e encontram-se entre as doenças mais negligenciadas no mundo. O arsenal terapêutico disponível é restrito, tóxico, caro e em algumas situações ineficazes, devido ao surgimento de cepas resistentes do parasito. No Brasil são registrados anualmente mais de 20 mil casos de leishmaniose tegumentar e a Leishmania braziliensis é a principal espécie causadora das formas clínicas cutânea e mucosa. Estudos prévios mostraram que o flavonóide quercetina tem ação terapêutica
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Cao, Huihui. "A mechanistic study on the anti-melanoma action of quercetin." HKBU Institutional Repository, 2015. https://repository.hkbu.edu.hk/etd_oa/165.

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The incidence and mortality rate of melanoma have increased greatly worldwide in the last thirty years. There is currently no effective treatment for malignant melanoma. Signal transducer and activator of transcription 3 (STAT3) signaling is constantly activated in human melanoma, which promotes melanoma development and progression. c-Met is a receptor tyrosine kinase (RTK), and hepatocyte growth factor (HGF) is the only known ligand of c-Met. Abnormal activation of HGF/c-Met has been implicated in melanoma metastasis. Both the STAT3 and HGF/c-Met signaling pathways are proposed as melanoma th
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Prysyazhnyuk, V. P. "Сomplex treatment with quercetin inclusion in chronic nonviral hepatitis patients". Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19576.

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Atulayo, F. "Influence of quercetin on inflammatory mediators levels in asthma patients." Thesis, Сумський державний університет, 2013. http://essuir.sumdu.edu.ua/handle/123456789/32799.

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Complex treatment with quercetin makes it possible to improve results of anti-inflammatory standard treatment in obese asthma patients. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/32799
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35

Guo, Yi. "EFFECTS OF ANTIOXIDANT STATUS AND ORAL DELIVERY SYSTEMSON QUERCETIN BIOAVAILABILITY." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1397058849.

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36

Abdalla, Fátima Husein. "EFEITO DA QUERCETINA NA ATIVIDADE DE ECTOENZIMAS E DA ACETILCOLINESTERASE EM SINAPTOSSOMAS DO CÓRTEX CEREBRAL DE RATOS EXPOSTOS AO CÁDMIO." Universidade Federal de Santa Maria, 2012. http://repositorio.ufsm.br/handle/1/11185.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>Cadmium (Cd) is one of the most toxic heavy metals by their ability to affect the vital organs like liver, kidney, brain and other. This metal can trigger a framework of oxidative stress by increase of reactive oxygen species and also affect cholinergic and purinergic neurotransmission. Quercetin (Querc), a flavonoid found in various foods has several functions in the body as a therapeutic antioxidant and neuroprotective action. The aim of this study was to evaluate the activity of ectoenzymes and acetylcholinesterase (AChE) acti
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37

Vicentini, Fabiana Testa Moura de Carvalho. "Efeito fotoquimioprotetor de quercetina incorporada em microemulsão contra os danos na pele causados pela radiação ultravioleta." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/60/60137/tde-15042009-162535/.

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A exposição à radiação ultravioleta (RUV) pode provocar desequilíbrio no balanço oxidante/antioxidante da pele, causando prejuízos à sua integridade e levando a diversas alterações, entre as quais o envelhecimento precoce e o câncer de pele. Considerando a estreita relação entre o aumento do estresse oxidativo e os efeitos danosos causados pela RUV na pele, aliado ao fato de que estudos epidemiológicos demonstram que o uso de protetores ou bloqueadores solares não é completamente efetivo na prevenção dos diversos malefícios causados pela exposição à RUV, o uso de antioxidantes aparece como imp
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38

Lucho, Ana Paula de Bairros. "Efeitos do Riluzole no Sistema Nervoso Central e Periférico de vertebrados." Universidade Federal do Pampa, 2014. http://dspace.unipampa.edu.br:8080/xmlui/handle/riu/619.

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Submitted by Ana Damasceno (ana.damasceno@unipampa.edu.br) on 2016-11-16T13:07:17Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Efeitos do Riluzole no Sistema Nervoso Central e Periférico de vertebrados..pdf: 3331266 bytes, checksum: 695a072e1aef84e61ff2e6ef010514a2 (MD5)<br>Made available in DSpace on 2016-11-16T13:07:17Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Efeitos do Riluzole no Sistema Nervoso Central e Periférico de vertebrados..pdf: 3331266 bytes, checksum: 695a072e1aef
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39

CORRIAS, FRANCESCO. "Nanocarriers for drug targeting and improved bioavailability." Doctoral thesis, Università degli Studi di Cagliari, 2014. http://hdl.handle.net/11584/266439.

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This PhD thesis debates, mostly, on two main topics: - Drug delivery to brain - Nanosuspensions for different applications The objective of the first topic was the development of liposomes to which anti-TfR-monoclonal antibodies (Ox26) or lactoferrin was bounded to transport the selective NK3 receptor agonist senktide to CNS across the BBB. NK3 receptors are widely expressed in the CNS and their stimulation by senktide (ICV) increase extracellular DA. Liposomes were prepared using the film hydration method. In vivo microdialysis studies were performed to estimate the responsiveness of NAc s
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40

Jones, Donald J. L. "The identification and characterisation of quercetin metabolites in humans and rats." Thesis, University of Leicester, 2001. http://hdl.handle.net/2381/30754.

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Quercetin is a dietary flavonoid, known to possess a range of biological properties of in in vitro systems. These properties may be of potential therapeutic benefit against certain diseases. Considerable work has focused on its antioxidant capability, which has been shown to be more powerful than that of vitamin E. Quercetin also has antineoplastic activity, and at 10M it inhibits the proliferation of malignant cell lines derived from breast, ovarian and gastrointestinal tumours and leukaemias. Therefore, a phase I clinical trial on cancer patients was conducted at the Queen Elizabeth Hospital
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41

Schwarz, Duncan. "The effect of quercetin rutinoside on experimental cholesterol atherosclerosis in rabbits /." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=64093.

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42

Beyer, Birgit [Verfasser]. "Untersuchungen zur Bioverfügbarkeit von Catechinen und Quercetin beim Rind / Birgit Beyer." Kiel : Universitätsbibliothek Kiel, 2015. http://d-nb.info/1076038360/34.

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43

Gilley, Andrew. "Amorphous solid dispersion effects on in vitro solution concentrations of quercetin." Thesis, Virginia Tech, 2016. http://hdl.handle.net/10919/72864.

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Quercetin is a flavonol with potential health benefits including activities against cardiovascular disease, obesity, and oxidative stress. However, the benefits of quercetin are likely limited by poor bioavailability, primarily attributed to its poor aqueous solubility (due to its hydrophobicity and crystallinity) and extensive phase-II metabolism. Improving the apparent solubility of quercetin has the potential to improve its in vivo bioavailability. Strategies to increase solution concentrations in the small intestinal lumen have the potential to substantially increase quercetin bioavailabil
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44

Schott, Adrian. "Silybin als Hemmstoff der Erythrozyten-Calzium-Pumpe im Vergleich mit Quercetin /." [S.l : s.n.], 1986. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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45

Stražnickienė, Alina. "Flavonoidų poveikis Hep 22a linijoms ląstelėms." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2006~D_20140702_190409-12658.

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Ląstelės metabolizme svarbų vaidmenį vaidina oksidacijos – redukcijos reakcijos, kuriose deguonis yra elektronų akceptorius. Įvairių cheminių reakcijų metu gali susidaryti ir aktyviosios deguonies formos – superoksido anijonas, vandenilio peroksidas, hidroksilo radikalas, singletinis deguonis, kurios pažeidžia įvairias biomolekules. Augalai nuo seniausių laikų yra vartojami įvairioms ligoms gydyti. Flavonoidai – tai augalinės kilmės junginiai, randami vaisiuose, daržovėse arbatose, kurie pasižymi antioksidacinėmis savybėmis. Sintetiniai antioksidantai polifenoliai labai plačiai naudojami maist
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46

Ranjbar, Golnaz. "Influence of lactase on the in vitro and in vivo antiglycaemic effects of onion flavonoids." Thesis, University of Hertfordshire, 2017. http://hdl.handle.net/2299/19461.

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Introduction: Lactase, in addition to its role in the digestion of lactose available in milk and dairy products, is implicated in the metabolism of a range of phenolic phytochemicals in the gut. Experiments with Caco-2 cells have shown that these cells which mimic the intestinal mucosa indicate that quercetin glucosides and quercetin aglycone (widely consumed in onions and apples) block glucose uptake from the gut by competing with glucose for the sodium-dependent SGLT-1 and sodium-independent GLUT-2 transporters respectively (Johnston et al., 2005a, Schulze et al., 2015). It has been suggeste
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Blöck, Markus. "Untersuchungen zur Interaktion von Quercetin-Glukosiden mit dem intestinalen Glukose-Carrier (SGLT1)." [S.l.] : [s.n.], 2002. http://www.diss.fu-berlin.de/2002/214/index.html.

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48

Azevedo, Maria Isabel Carneiro de. "Effect of flavonoids rutin and quercetin in peripheral neuropathy induced sensitive oxaliplatin." Universidade Federal do CearÃ, 2012. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=10494.

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Oxaliplatin is a third-generation platinum compound and the first-line treatment for colorectal cancer. The main limiting factor in oxaliplatin treatment is painful neuropathy that is difficult to treat. This side effect has been studied for several years, but its full mechanism is still inconclusive, and effective treatment does not exist. Data suggest that oxaliplatinâs initial neurotoxic effect is peripheral and oxidative stress-dependent. A spinal target is also suggested in its mechanism of action. The flavonoids rutin and quercetin have been described as cell-protecting agents because of
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49

Tsao, Chin-Wan, and 曹智菀. "Quercetin pharmacokinetics and the effect of quercetin on cyclosporin absorption." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/86829191668214701645.

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碩士<br>中國醫藥學院<br>藥物化學研究所<br>87<br>Quercetin is a bioactive natural product and possesses many beneficial pharmacological activities. The purpose of this study was to investigate the pharmacokinetics of quercetin in rabbits. Metabolites of quercetin in serum were hydrolyzed anaerobically by incubation with β-glucuronidase/sulfatase at 37℃for 4 hr with the addition of ascorbic acid. A sensitive and simple HPLC method for determination of quercetin in rabbit's serum was developed. The analysis was performed on Cosmosil RP-18 column with a mobile phase consisting of acetonitrile : 0.2 % ortho-phosp
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50

Gräfe, Eva Ulrike. "Relative systemische Verfügbarkeit und Pharmakokinetik von Quercetin und Quercetinglykosiden (Quercetin-4'-0-glucosid und Quercetin-3-0-rutinosid) im Menschen." Doctoral thesis, 2001. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-1333.

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Aufgrund seiner potentiell gesundheitsfoerdernden Wirkung wurde das Falvonol Quercetin in den letzten Jahren intensiv untersucht. Daten zur Bioverfuegbarkeit nach oraler Applikation sind jedoch selten und widerspruechlich. Fruehere Untersuchungen deuteten darauf hin, dass die Disposition von Quercetin von der Zuckerkomponente des Glykosids oder der Pflanzenmatrix abhaengen koennte. Um den Einfluss der Zuckerkomponente oder der Matrix auf die Resorption von Quercetin festzustellen, wurden zwei isolierte Quercetinglykoside sowie zwei Pflanzenextrakte in einer vierarmigen, randomisierten cross-ov
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