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Journal articles on the topic 'Quercetin'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Jang, Ae-Ra, Jun-Sang Ham, Dong-Wook Kim, et al. "Effect of Quercetin and Methoxylated Quercetin on Chicken Thigh Meat Quality during Cold Storage." Korean Journal of Poultry Science 38, no. 4 (2011): 265–73. http://dx.doi.org/10.5536/kjps.2011.38.4.265.

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2

Saxena, Vasundhara, Durga Prameela Gaddam, Anupam Verma, et al. "FORMULATION AND CHARACTERIZATION OF QUERCETIN PHYTOSOME-INFUSED HYDROGEL FOR ENHANCED SKIN PENETRATION IN PSORIASIS MANAGEMENT." International Journal of Environmental Sciences 11, no. 6s (2025): 1041–47. https://doi.org/10.64252/mm3eg290.

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Abstract: Psoriasis is a chronic inflammatory skin disease requiring effective topical treatments with enhanced skin penetration and sustained therapeutic effect. This study aimed to formulate and characterize a Quercetin phytosome-infused hydrogel to improve quercetin's bioavailability and skin retention for psoriasis management. Quercetin phytosomes were prepared via the anti-solvent precipitation method, yielding nanosized particles (400–500 nm) with a narrow distribution (PDI < 0.4) and high entrapment efficiency (>80%). Fourier-Transform Infrared Spectroscopy and proton nuclear magn

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3

Preethi, Arul Murugan, and Jayesh R. Bellare. "Concomitant Effect of Quercetin- and Magnesium-Doped Calcium Silicate on the Osteogenic and Antibacterial Activity of Scaffolds for Bone Regeneration." Antibiotics 10, no. 10 (2021): 1170. http://dx.doi.org/10.3390/antibiotics10101170.

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Quercetin is a bioflavonoid which has a broad spectrum of biological activity. Due to its lower chemical stability, it is usually encapsulated, or a metal–quercetin complex is formed to enhance its biological activity at a lower concentration. Here, our novel approach was to form a quercetin complex to magnesium-doped calcium silicate (CMS) ceramics through a coprecipitation technique so as to take advantage of quercetin’s antibacterial activity within the antibacterial and osteogenic potential of the silicate. Due to quercetin’s inherent metal-chelating ability, (Ca+Mg)/Si increased with quer

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4

Shabana, R. C. Jaysree, and Rajendran N. "Review on the Bioactivities of Quercetin." International Journal of ChemTech Research 13, no. 3 (2020): 181–94. http://dx.doi.org/10.20902/ijctr.2019.130315.

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Quercetin, the most active bioflavonoid which is produced as a secondary metabolite by plants, is a polyphenol with a wide spectrum of bioactivities. This bioflavonoid is the ―nature‘s biological response modifier‖ as it interferes with the various allergens and other reactive compounds. Apple, oranges, tomatoes, onions, black tea and green tea are good sources of quercetin and it is also available commercially. After absorption in the small intestine and colon, quercetin conjugates with glucuronic acid and binds to albumin and passes to liver and benefits the body by its various bioactivities

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Ding, Kaixi, Wei Jiang, Wenling Zhan, et al. "The therapeutic potential of quercetin for cigarette smoking–induced chronic obstructive pulmonary disease: a narrative review." Therapeutic Advances in Respiratory Disease 17 (January 2023): 175346662311708. http://dx.doi.org/10.1177/17534666231170800.

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Quercetin is a flavonoid with antioxidant and anti-inflammatory properties. Quercetin has potentially beneficial therapeutic effects for several diseases, including cigarette smoking–induced chronic obstructive pulmonary disease (CS-COPD). Many studies have shown that quercetin’s antioxidant and anti-inflammatory properties have positive therapeutic potential for CS-COPD. In addition, quercetin’s immunomodulatory, anti-cellular senescence, mitochondrial autophagy–modulating, and gut microbiota–modulating effects may also have therapeutic value for CS-COPD. However, there appears to be no revie

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Boo, Hye Joon, Danbi Yoon, Yujeong Choi, Younghyun Kim, Jeong Seok Cha, and Jiho Yoo. "Quercetin: Molecular Insights into Its Biological Roles." Biomolecules 15, no. 3 (2025): 313. https://doi.org/10.3390/biom15030313.

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Quercetin, a prevalent plant flavonoid, demonstrates many biological functions through its interaction with distinct protein targets. Recent structural investigations of protein–quercetin complexes have elucidated the molecular mechanism behind these actions. This paper presents a thorough structural analysis of experimentally established protein–quercetin complex structures published to date. The structure of the protein–quercetin complex elucidates the molecular mechanism by which quercetin influences protein function. These structures illustrate how quercetin’s chemical characteristics faci

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Zhao, Chenhui, and Thomas Ming Swi Chang. "Biodegradable Polylactide Nanocapsules Containing Quercetin for In Vitro Suppression of Mouse B16F10 and Human Sk-Mel-28 Melanoma Cell Lines." Pharmaceuticals 18, no. 7 (2025): 980. https://doi.org/10.3390/ph18070980.

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Background: Quercetin is a flavonoid found in various dietary sources. It is a prodrug converted by overexpressed tyrosinase in melanoma into an active o-quinone that suppresses tumour growth. However, injected quercetin is rapidly cleared from the tumour site. Method: Our study aimed to enhance quercetin’s efficacy through nanoencapsulation using biodegradable nanocapsules, which were tested in both mouse and human melanoma cell lines in 2D and 3D models. Results: Nanoencapsulation achieved sustained release and improved bioavailability. In mouse 2D cultures, quercetin nanocapsules (Q-nanos)

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Matsuo, Mana, Shuang Liu, Haruna Yamada, Erika Takemasa, Yasuyuki Suzuki, and Masaki Mogi. "Time-sensitive effects of quercetin on rat basophilic leukemia (RBL-2H3) cell responsiveness and intracellular signaling." PLOS ONE 20, no. 2 (2025): e0319103. https://doi.org/10.1371/journal.pone.0319103.

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Quercetin is known for its ability to inhibit mast cell degranulation and reduce the release of inflammatory mediators. However, it has also been reported to sensitize mast cells, potentially leading to hyperresponsiveness. This necessitates careful optimization of its use in the treatment of chronic inflammatory diseases. To fully harness quercetin’s therapeutic potential, this study investigated the effects of quercetin on rat basophilic leukemia (RBL-2H3) cells responsiveness over varying durations of exposure. We employed comprehensive transcriptome analysis and subsequent functional valid

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9

Frenț, Olimpia-Daniela, Liana Stefan, Claudia Mona Morgovan, et al. "A Systematic Review: Quercetin—Secondary Metabolite of the Flavonol Class, with Multiple Health Benefits and Low Bioavailability." International Journal of Molecular Sciences 25, no. 22 (2024): 12091. http://dx.doi.org/10.3390/ijms252212091.

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The main goal of this systematic review on the flavonol class secondary metabolite quercetin is to evaluate and summarize the existing research on quercetin’s potential health benefits, therapeutic properties, and effectiveness in disease prevention and treatment. In addition to evaluating quercetin’s potential for drug development with fewer side effects and lower toxicity, this type of review attempts to collect scientific evidence addressing quercetin’s roles as an antioxidant, anti-inflammatory, antibacterial, and anticancer agent. In the first part, we analyze various flavonoid compounds,

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Osterc, G., M. Štefančič, A. Solar, and F. Štampar. "Potential involvement of flavonoids in the rooting response of chestnut hybrid (Castanea crenata × Castanea sativa) clones." Australian Journal of Experimental Agriculture 47, no. 1 (2007): 96. http://dx.doi.org/10.1071/ea05149.

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The involvement of different quercetins [quercetin-3-O-rhamnoside (quercitrin), quercetin-3-D-galactoside (hyperoside) and rutin] and catechins (catechin, catechol) in the rooting process of leafy cuttings was studied in two hybrid chestnut (Castanea crenata × Castanea sativa) clones, Maraval and Marsol. Both clones differed strongly in rooting results. The Maraval clone cuttings, which had a high rooting rate, contained, on average, higher amounts of all quercetins in different plant parts (leaves and basal cuttings) than the Marsol clone, which had a low rooting rate. There was a highly sign

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Chen, Nannan, Yu Liu, Tongtong Bai, et al. "Quercetin Inhibits Hsp70 Blocking of Bovine Viral Diarrhea Virus Infection and Replication in the Early Stage of Virus Infection." Viruses 14, no. 11 (2022): 2365. http://dx.doi.org/10.3390/v14112365.

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Bovine viral diarrhea virus (BVDV), a positive-strand RNA virus of the genus Pestivirus in the Flaviviridae family, is the causative agent of viral diarrheal disease in bovine. BVDV has been used as a surrogate model for the hepatitis C virus (HCV) to evaluate the efficacy of antiviral drugs. The plant flavonol quercetin causes multiple health-promoting effects in humans and animals. It can be made into a variety of additives, and it exerts a variety of immunomodulatory effects with the potential to be used as an antiviral agent. However, quercetin’s antiviral effect and mechanism of action on

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Yuan, Haihua, Hang Xun, Jie Wang, Jin Wang, Xi Yao, and Feng Tang. "Integrated Metabolomic and Transcriptomic Analysis Reveals the Underlying Antibacterial Mechanisms of the Phytonutrient Quercetin-Induced Fatty Acids Alteration in Staphylococcus aureus ATCC 27217." Molecules 29, no. 10 (2024): 2266. http://dx.doi.org/10.3390/molecules29102266.

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The utilization of natural products in food preservation represents a promising strategy for the dual benefits of controlling foodborne pathogens and enhancing the nutritional properties of foods. Among the phytonutrients, flavonoids have been shown to exert antibacterial effects by disrupting bacterial cell membrane functionality; however, the underlying molecular mechanisms remain elusive. In this study, we investigated the effect of quercetin on the cell membrane permeability of Staphylococcus aureus ATCC 27217. A combined metabolomic and transcriptomic approach was adopted to examine the r

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Buljeta, Ivana, Ina Ćorković, Anita Pichler, Josip Šimunović, and Mirela Kopjar. "Application of Citrus and Apple Fibers for Formulation of Quercetin/Fiber Aggregates: Impact of Quercetin Concentration." Plants 11, no. 24 (2022): 3582. http://dx.doi.org/10.3390/plants11243582.

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Among flavonoids, quercetin has gained special attention due to its positive biological activities. Quercetin’s disadvantages, such as its hydrophobic nature, poor solubility, and permeability, could be overcome by complexation with different polymers. Dietary fibers are known as carriers of polyphenols, which can protect them from environmental conditions and thus allow them to be absorbed. In this study, apple and citrus fibers (as applicable food by-products) were used as carriers of quercetin. A constant amount of fibers (1%) and different concentrations of quercetin solution (5 mM, 10 mM,

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Metwaly, Ahmed M., Esmail M. El-Fakharany, Aisha A. Alsfouk, Ibrahim M. Ibrahim, Eslam B. Elkaeed, and Ibrahim H. Eissa. "Integrated study of Quercetin as a potent SARS-CoV-2 RdRp inhibitor: Binding interactions, MD simulations, and In vitro assays." PLOS ONE 19, no. 12 (2024): e0312866. https://doi.org/10.1371/journal.pone.0312866.

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To find an effective inhibitor for SARS-CoV-2, Quercetin’s chemical structure was compared to nine ligands associated with nine key SARS-CoV-2 proteins. It was found that Quercetin closely resembles Remdesivir, the co-crystallized ligand of RNA-dependent RNA polymerase (RdRp). This similarity was confirmed through flexible alignment experiments and molecular docking studies, which showed that both Quercetin and Remdesivir bind similarly to the active site of RdRp. Molecular dynamics (MD) simulations over a 200 ns trajectory, analyzing various factors like RMSD, RG, RMSF, SASA, and hydrogen bon

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15

Li, Xiu-Mei, Zhong-Yuan Li, Ya-Dong Wang, Jin-Quan Wang, and Pei-Long Yang. "Quercetin Inhibits the Proliferation and Aflatoxins Biosynthesis of Aspergillus flavus." Toxins 11, no. 3 (2019): 154. http://dx.doi.org/10.3390/toxins11030154.

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In this work of quercetin’s anti-proliferation action on A. flavus, we revealed that quercetin can effectively hamper the proliferation of A. flavus in dose-effect and time-effect relationships. We tested whether quercetin induced apoptosis in A. flavus via various detection methods, such as phosphatidylserine externalization and Hoechst 33342 staining. The results showed that quercetin had no effect on phosphatidylserine externalization and cell nucleus in A. flavus. Simultaneously, quercetin reduced the levels of reactive oxygen species (ROS). For a better understanding of the molecular mech

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Wang, Yu Jie, and Bing Wang. "Preparation of Quercetin-Ni⁺² Metal-Complexing Imprinted Polymer and its Recognition Performance Evaluation." Applied Mechanics and Materials 275-277 (January 2013): 1697–700. http://dx.doi.org/10.4028/www.scientific.net/amm.275-277.1697.

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Using the complex of quercetin and Ni+2 (quercetin-Ni+2) as template (quercetin is a kind of flavonoids which are important active ingredients of Chinese herbs.), methacrylic acid as functional monomer and ethylene glycol dimethacrylate as cross-linker, metal-complexing template polymer has been prepared in the mixed solution of methanol and tetrahydrofuran by molecular imprinting technique. The coordination structure and complex ratio between quercetin and Ni+2 were studied by UV-visible spectroscopy, and the ternary complexation of quercetin, Ni+2 and methacrylic acid was verified by similar

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Ranjan Kumar Singh, J Pavan Kumar, Chennu MM Prasada Rao, Rajeswari Tannairu, and Ajay Garg. "RECENT DEVELOPMENTS IN QUERCETIN-LOADED NANOPARTICLES FOR CANCER TARGETING." Tropical Journal of Pharmaceutical and Life Sciences 12, no. 1 (2025): 11–23. https://doi.org/10.61280/tjpls.v12i1.174.

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Quercetin, a dietary polyphenol, has demonstrated anticancer properties across several malignancies, including pancreatic cancer, breast cancer, and melanoma. Quercetin is a naturally occurring bioflavonoid found in fruits, vegetables, seeds, berries, and tea. The cancer-preventive properties of quercetin are well established, attributed to its anti-inflammatory, anti-proliferative, and anti-angiogenic effects. Nonetheless, the inadequate water solubility and transport, chemical instability, brief half-life, and low bioavailability of quercetin restrict its therapeutic use in cancer chemopreve

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Singh, Neelam, Mukesh Kumar Meena, and Vidya Patni. "HPTLC method for isolation, identification and quantification of quercetin from in vivo and in vitro samples of Naringi Crenulata." Indian Journal of Pharmaceutical and Biological Research 5, no. 03 (2017): 26–31. http://dx.doi.org/10.30750/ijpbr.5.3.4.

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Naringi crenulata(Roxb.) Nicolson, is a rare medicinal plant belonging to the family Rutaceae. It is a spinous tree and has great medicinal value. During the present study a rapid, simple, accurate and specific HPTLC method for quantitative estimation of quercetin present in the dried leaf powder and callus of N. crenulata has been developed .The method used in this work resulted in good peak shape and enabled good resolution of quercetin from N. crenulata samples. Quercetin was identified in in vivo (leaf) and in vitro (six weeks old callus) tissues. Presence of isolated quercetin was further

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Singh, Neelam, Mukesh Kumar Meena, and Vidya Patni. "HPTLC method for isolation, identification and quantification of quercetin from in vivo and in vitro samples of Naringi crenulata." Indian Journal of Pharmaceutical and Biological Research 6, no. 02 (2018): 05–09. http://dx.doi.org/10.30750/ijpbr.6.2.2.

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Naringi crenulata (Roxb.) Nicolson, is a rare medicinal plant belonging to the family Rutaceae. It is a spinous tree and has great medicinal value. During the present study a rapid, simple, accurate and specific HPTLC method for quantitative estimation of quercetin present in the dried leaf powder and callus of N. crenulata has been developed .The method used in this work resulted in good peak shape and enabled good resolution of quercetin from N. crenulata samples. Quercetin was identified in in vivo (leaf) and in vitro (six weeks old callus) tissues. Presence of isolated quercetin was furthe

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Kim, Dae-Youn, and Tae-Jong Kim. "Metabolic Stress Induced by Quercetin Enhances Dormancy and Persistence in Staphylococcus aureus." Antibiotics 14, no. 5 (2025): 424. https://doi.org/10.3390/antibiotics14050424.

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Background/Objectives: The persistence of Staphylococcus aureus poses a significant challenge in clinical treatments because of its ability to withstand antibiotic therapy. This study assessed the role of quercetin in promoting bacterial dormancy and persistence through ATP depletion and revealed its potential impact on antibiotic tolerance. Methods: To assess the effects of quercetin on bacterial metabolism and persistence, S. aureus cultures were treated with quercetin, and intracellular ATP levels were then measured. The effect of quercetin on persister cell formation was assessed using ant

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Jung, Min Kyung, and Dae-Ho Cho. "Tannic acid and quercetin display a therapeutic effect on atopic dermatitis via suppression of angiogenesis and Th2 polarization. (97.7)." Journal of Immunology 184, no. 1_Supplement (2010): 97.7. http://dx.doi.org/10.4049/jimmunol.184.supp.97.7.

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Abstract Atopic dermatitis (AD) is a chronic inflammatory skin disease that is characterized by inflammation, abnormal angiogenesis and elevated Th2 polarization. Tannic acid (TA) and quercetin are well known polypenolic compounds, have documented anti-inflammatory effect. However, little is known about the effects of TA and quercetin on atopic dermatitis and related mechanisms. The present study investigated whether TA and quercetin had a therapeutic effect on atopic dermatitis. In vitro, we found that TA and quercetins reduced pro-angiogenic factor and Th2-inducing cytokine in human keratino

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Sudjarwo. "Determination of Queercetin Content in Preparation of Powder Extract of Starfruit Leaves (Averrhoa bilimbi L.) by TLC-Densitometry." Berkala Ilmiah Kimia Farmasi 10, no. 1 (2023): 1–6. http://dx.doi.org/10.20473/bikfar.v10i1.51432.

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Quercetin is a flavonoid from Averrhoa bilimbi Linn. which has a variety of potential therapeutic. Therefore, this research is needed to determine the quercetin content in Averrhoa bilimbi L.’s extract powder. Method Validation is performed to ensure that an analytical method meets the criteria and requirements of a good analysis method. Method Validation used was the first category with parameters of selectivity, linearity, accuracy, and precision. The quercetin content in Averrhoa bilimbi L.’s leaf was small, requiring a parameter Limit of Detection (LOD) and Limit of Quantitation (LOQ). The

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Fatima, Sabiha, Muthukala Borappa, Sivakumari Kanakarajan, et al. "Apoptosis, DNA damage, and cell cycle arrest: The anticancer mechanisms of quercetin in human cervix epithelioid carcinoma cells." International Journal of Health Sciences 19 (May 1, 2025): 43–51. https://doi.org/10.25259/oa05_8747.

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Objectives The objectives of the study are to investigate the anti-cancer properties of quercetin, a widely distributed phytochemical, and assess its potential as a chemopreventive and therapeutic agent for cervical cell carcinoma. Methods The study employed cell viability assays for cytotoxicity, flow cytometry for cell cycle arrest, comet assays for DNA damage, nuclear morphology to assess apoptosis, and Western blotting to measure caspase 3 expression, a key apoptosis-related marker. Results Notably, a significantly lower half-maximal inhibitory concentration (25.5 μM) at 48 h compared to 2

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Vendramin, Veronica, Daniele Pizzinato, Céline Sparrow, et al. "Prevention of quercetin precipitation in red wines: a promising enzymatic solution." OENO One 56, no. 1 (2022): 41–51. http://dx.doi.org/10.20870/oeno-one.2022.56.1.4699.

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Flavonols are known for causing undesirable deposits in both red and white wines. Among flavonols, quercetin is widely considered the principal factor determining this phenomenon. One of the most accredited hypotheses claims that glycosylated derivatives of quercetin undergo hydrolysis of the glycosylic bond during the fermentation and the wine ageing, releasing quercetin aglycone, which is much less soluble in water solution and causes the precipitation. Our work describes the dynamics of quercetin-derived deposition in Chianti wines and purposes a new method, based on the enzymatic quercetin

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Guan, Hui, Wenyuan Zhang, Hui Liu, et al. "Quercetin Induces Apoptosis in HepG2 Cells via Directly Interacting with YY1 to Disrupt YY1-p53 Interaction." Metabolites 13, no. 2 (2023): 229. http://dx.doi.org/10.3390/metabo13020229.

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Quercetin is a flavonol found in edible plants and possesses a significant anticancer activity. This study explored the mechanism by which quercetin prevented liver cancer via inducing apoptosis in HepG2 cells. Quercetin induced cell proliferation and apoptosis through inhibiting YY1 and facilitating p53 expression and subsequently increasing the Bax/Bcl-2 ratio. The results revealed that YY1 knockdown promoted apoptosis, whilst YY1 overexpression suppressed apoptosis via direct physical interaction between YY1 and p53 to regulate the p53 signaling pathway. Molecular docking using native and m

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Martynov, A.V, E.A Batrak, and T.V Kabluchko. "HPLC FOR CONTROL STABILITY OF QUERCETIN INJECTABLE DOSAGE." Annals of Mechnikov Institute, no. 4 (December 2, 2016): 53–57. https://doi.org/10.5281/zenodo.192301.

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Introduction. Quercetin is a flavone derivatives which known like a substances with vitamin activity, high antioxidant, antimutagenic and anticarcinogenic activity and many other types of biological activity. Wide usage of quercetin prevents their polyphenolic nature structure which does not allow a high bioavailability of pure quercetin when administered orally. This is associated with a wide spectrum variety of chemical reactions for the phenolic groups: from interaction with amino acid residues in proteins to reactions with amine heterocyclic alkaloids and polysaccharides. In our days Corvi

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Sulyman, Abdulhakeem Olarewaju, Tafa Ndagi Akanbi Yusuf, Jamiu Olaseni Aribisala, et al. "Quercetin as a Modulator of PTPN22 Phosphomonoesterase Activity: A Biochemical and Computational Evaluation." Current Issues in Molecular Biology 46, no. 10 (2024): 11156–75. http://dx.doi.org/10.3390/cimb46100662.

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Cancer, a group of diseases characterized by uncontrollable cell proliferation and metastasis, remains a global health challenge. This study investigates quercetin, a natural compound found in many fruits and vegetables, for its potential to inhibit the phosphomonoesterase activity of protein tyrosine phosphatase nonreceptor type 22 (PTPN22), a key immune response regulator implicated in cancer and autoimmune diseases. We started by screening seven (7) natural compounds against the activities of PTPN22 in vitro. The initial screening identified quercetin with the highest percentage inhibition

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Gao, Min, and Guang-Yan Tang. "Structural Basis for Great Protein-Binding Potential of Flavonoids: A Case Study of Quercetin." Natural Product Communications 12, no. 11 (2017): 1934578X1701201. http://dx.doi.org/10.1177/1934578x1701201142.

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Flavonoids exhibit a wide variety of biological effects and hold great protein-binding potential. In this study, we take quercetin, an extensively studied flavonoid, as an example to investigate the structural basis underlying their excellent protein-binding ability. Through calculating the pocket similarity of quercetin-binding proteins and comparing the binding modes between quercetins bound with different proteins, it was found that the great protein-binding capacity of quercetin not only arises from the structural conservation of target proteins, but also stems from its unique structure, i

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Ali, Esmail Al-Snafi. "CHEMICAL CONSTITUENTS AND PHARMACOLOGICAL EFFECTS OF HYPERICUM TRIQUETRIFOLIUM." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 03 (2018): 1757–65. https://doi.org/10.5281/zenodo.1210525.

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Hypericum triquetrifolium contained many biologically active chemicals included acylphloroglucinols triquetrireboudin, triquetriborin, essential and volatile oils and many phenolic compounds. Hypericum triquetrifolium contained hyperforin 0.013 ± 0.000 and hypericin 0.020 ± 0.001 w/w%. Many phenolics were isolated from Hypericum triquetrifolium included chlorogenic acid, caffeoylquinic acid, p-coumaroylquinic acid, epicatechin, rutin, hyperoside, I3,II8-biapigenin, isoquercetine, quercitrine, quercetine, quercetin galactoside, quercetin rutinoside, quercetin-3-O-galactoside, kaem

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Kothan, S., S. Dechsupa, G. Leger, J. L. Moretti, J. Vergote, and S. Mankhetkorn. "Spontaneous mitochondrial membrane potential change during apoptotic induction by quercetin in K562 and K562/adr cells." Canadian Journal of Physiology and Pharmacology 82, no. 12 (2004): 1084–90. http://dx.doi.org/10.1139/y04-113.

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Natural products from plants such as flavonoids are potential drugs to overcome multidrug resistance (MDR) in cancer treatments. However, their modes of action are still unclear. In this study, the effects of quercetin on mitochondrial membrane potential (ΔΨm) change as well as quercetin's ability to induce apoptosis and inhibit Pgp-mediated efflux of 99mTc-MIBI in K562/adr cells were investigated. Quercetin exhibits cytotoxicity against erythroleukemic cells: IC50 are 11.0 ± 2.0 µmol/L and 5.0 ± 0.4 µmol/L for K562 and K562/adr, respectively. Quercetin induces cell death via apoptosis in both

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Guo, Chao, Wen-Jun Wang, Yu-Cheng Liao, et al. "Effect and Mechanisms of Quercetin for Experimental Focal Cerebral Ischemia: A Systematic Review and Meta-Analysis." Oxidative Medicine and Cellular Longevity 2022 (February 25, 2022): 1–13. http://dx.doi.org/10.1155/2022/9749461.

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Quercetin, a naturally occurring flavonoid, is mainly extracted from tea, onions, and apples. It has the underlying neuroprotective effect on experimental ischemic stroke. A systematic review and meta-analysis were used to assess quercetin’s efficacy and possible mechanisms in treating focal cerebral ischemia. Compared with the control group, twelve studies reported a remarkable function of quercetin in improving the neurological function score (NFS) ( P < 0.05 ), and twelve studies reported a significant effect on reducing infarct volume ( P < 0.05 ). Moreover, two and three studies sho

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Tarabara, Uliana, Valeriya Trusova, and Galyna Gorbenko. "Protective Effect of Quercetin on Amyloid-Induced Alterations in Lipid Bilayer Integrity." East European Journal of Physics, no. 3 (September 2, 2024): 479–83. http://dx.doi.org/10.26565/2312-4334-2024-3-58.

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The present study employs molecular dynamics simulations to investigate the interactions between quercetin, amyloid fibrils, and POPC lipid bilayers. The results demonstrate that quercetin does not significantly affect the molecular organization of the bilayer, while IAPP fibrils induce substantial structural changes, particularly in the outer monolayer. Quercetin mitigates these effects by reducing the impact on headgroup and glycerol regions and causing a more superficial positioning of IAPP. Additionally, quercetin slightly decreases the order of sn-2 acyl chains, indicating a disordering e

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Ruiz, Lina M., Celia Salazar, Erik Jensen, et al. "Quercetin Affects Erythropoiesis and Heart Mitochondrial Function in Mice." Oxidative Medicine and Cellular Longevity 2015 (2015): 1–12. http://dx.doi.org/10.1155/2015/836301.

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Quercetin, a dietary flavonoid used as a food supplement, showed powerful antioxidant effects in different cellular models. However, recentin vitroandin vivostudies in mammals have suggested a prooxidant effect of quercetin and described an interaction with mitochondria causing an increase inO2∙-production, a decrease in ATP levels, and impairment of respiratory chain in liver tissue. Therefore, because of its dual actions, we studied the effect of quercetinin vivoto analyze heart mitochondrial function and erythropoiesis. Mice were injected with 50 mg/kg of quercetin for 15 days. Treatment wi

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Laksmiani, Ni Putu Linda, I. Wayan Agus Widiantara, and Andrew Borneo Salian Pawarrangan. "Potency of moringa (Moringa oleifera L.) leaves extract containing quercetin as a depigmentation agent inhibiting the tyrosinase enzyme using in-silico and in-vitro assay." Pharmacia 69, no. 1 (2022): 85–92. http://dx.doi.org/10.3897/pharmacia.69.e73132.

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Hyperpigmentation is a disorder of facial skin pigments due to an increase in the process of melanogenesis, which can cause a darkening of skin color. A flavonoid compound with potential as a skin-lightening agent is quercetin, commonly found in Moringa oleifera L. leaves. This study aims to determine quercetin’s affinity and molecular mechanism on tyrosinase enzyme target proteins using an in-silico molecular docking method. Docking of quercetin with the tyrosinase enzyme produced a bond energy value of -7.08 kcal/mol. In comparison, the tropolone as a native ligand with the tyrosinase enzyme

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Koleini, Toktam Sadat, Seyed Jalal Zargar, Shahrokh Safarian, and Mostafa Saberian. "Increasing the Sensitivity of MCF-7 Breast Cancer Cells to Quercetin by Declining DFF45 Expression Level." Jundishapur journal of Medical Sciences 21, no. 6 (2023): 776–92. http://dx.doi.org/10.32598/jsmj.21.6.2435.

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Background and Objectives In recent years, flavonoids such as quercetin have been considered as new anticancer drugs. The mechanisms of action of quercetin include cell cycle arrest, inhabitation of cell proliferation, and induction of apoptosis. This study aims to reduce quercetin’s side effects by increasing MCF-7 breast cancer cells’ sensitivity to this drug and facilitating the cytotoxic effects of quercetin at lower concentrations. Subjects and Methods In this study, the MTT assay was used to determine the concentration that reduced the cell viability by 50% (i.e. lethal concentration 50

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Naso, Matteo, Chiara Trincianti, Maria Angela Tosca, and Giorgio Ciprandi. "Quercetin and Its Lecithin-Based Formulation: Potential Applications for Allergic Diseases Based on a Narrative Review." Nutrients 17, no. 9 (2025): 1476. https://doi.org/10.3390/nu17091476.

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Quercetin, a natural flavonoid, present in various vegetables and fruits, has garnered increasing attraction for its potential antiallergic properties. Its broad-spectrum activity depends on its anti-inflammatory, immunomodulatory, and antioxidant effects, which target the critical pathways involved in type 2-driven allergic inflammation. Quercetin inhibits mast cell degranulation, reduces the production of histamine and pro-inflammatory cytokines, and restores homeostasis of the immune system by modulating the Th1/Th2 and Treg/Th17 balances. Additionally, its antioxidant properties help to da

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Seo, Sang Young, Won Seok Ju, Kyongtae Kim, et al. "Quercetin Induces Mitochondrial Apoptosis and Downregulates Ganglioside GD3 Expression in Melanoma Cells." International Journal of Molecular Sciences 25, no. 10 (2024): 5146. http://dx.doi.org/10.3390/ijms25105146.

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Malignant melanoma represents a form of skin cancer characterized by a bleak prognosis and heightened resistance to traditional therapies. Quercetin has demonstrated notable anti-carcinogenic, anti-inflammatory, anti-oxidant, and pharmacological effects across various cancer types. However, the intricate relationship between quercetin’s anti-cancer properties and ganglioside expression in melanoma remains incompletely understood. In this study, quercetin manifests specific anti-proliferative, anti-migratory, and cell-cycle arrest effects, inducing mitochondrial dysfunction and apoptosis in two

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Rayamajhi, Nabin, Seul-Ki Kim, Hiroe Go, et al. "Quercetin Induces Mitochondrial Biogenesis through Activation of HO-1 in HepG2 Cells." Oxidative Medicine and Cellular Longevity 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/154279.

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The regeneration of mitochondria by regulated biogenesis plays an important homeostatic role in cells and tissues and furthermore may provide an adaptive mechanism in certain diseases such as sepsis. The heme oxygenase (HO-1)/carbon monoxide (CO) system is an inducible cytoprotective mechanism in mammalian cells. Natural antioxidants can provide therapeutic benefit, in part, by inducing the HO-1/CO system. This study focused on the mechanism by which the natural antioxidant quercetin can induce mitochondrial biogenesis in HepG2 cells. We found that quercetin treatment induced expression of mit

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Oh, Won Jun, Mehari Endale, Seung-Chun Park, Jae Youl Cho, and Man Hee Rhee. "Dual Roles of Quercetin in Platelets: Phosphoinositide-3-Kinase and MAP Kinases Inhibition, and cAMP-Dependent Vasodilator-Stimulated Phosphoprotein Stimulation." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/485262.

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Background. Progressive diseases including cancer, metabolic, and cardiovascular disorders are marked by platelet activation and chronic inflammation. Studies suggest that dietary flavonoids such as quercetin possess antioxidant, anti-inflammatory, and antiplatelet properties, which could prevent various chronic diseases including atherosclerosis and thrombosis. However, the mechanism and the signaling pathway that links quercetin's antiplatelet activity with its anti-inflammatory property is limited and thus further exploration is required. The aim of this paper was to examine the link betwee

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Aghababaei, Fatemeh, and Milad Hadidi. "Recent Advances in Potential Health Benefits of Quercetin." Pharmaceuticals 16, no. 7 (2023): 1020. http://dx.doi.org/10.3390/ph16071020.

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Quercetin, a flavonoid found in fruits and vegetables, has been a part of human diets for centuries. Its numerous health benefits, including antioxidant, antimicrobial, anti-inflammatory, antiviral, and anticancer properties, have been extensively studied. Its strong antioxidant properties enable it to scavenge free radicals, reduce oxidative stress, and protect against cellular damage. Quercetin’s anti-inflammatory properties involve inhibiting the production of inflammatory cytokines and enzymes, making it a potential therapeutic agent for various inflammatory conditions. It also exhibits an

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Aditi Gajanan Asole and Madhuri D. Game. "A novel stability indicating HPTLC method for comparative quantitative estimation of quercetin in herbal preparations." GSC Biological and Pharmaceutical Sciences 27, no. 2 (2024): 262–75. http://dx.doi.org/10.30574/gscbps.2024.27.2.0178.

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This research introduces a novel stability-indicating HPTLC (High-Performance Thin-Layer Chromatography) method for the comparative quantitative estimation of Quercetin in herbal preparations. Through extensive stability studies, the method is validated, providing a robust framework for evaluating Quercetin's stability in diverse herbal formulations. The developed method ensures accurate and reliable quantification of Quercetin, facilitating comparative analysis across various herbal preparations. Additionally, results reveal that Quercetin degraded under most tested conditions, such as acidic

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Aditi, Gajanan Asole, and D. Game Madhuri. "A novel stability indicating HPTLC method for comparative quantitative estimation of quercetin in herbal preparations." GSC Biological and Pharmaceutical Sciences 27, no. 2 (2024): 262–75. https://doi.org/10.5281/zenodo.12540638.

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This research introduces a novel stability-indicating HPTLC (High-Performance Thin-Layer Chromatography) method for the comparative quantitative estimation of Quercetin in herbal preparations. Through extensive stability studies, the method is validated, providing a robust framework for evaluating Quercetin's stability in diverse herbal formulations. The developed method ensures accurate and reliable quantification of Quercetin, facilitating comparative analysis across various herbal preparations. Additionally, results reveal that Quercetin degraded under most tested conditions, such as acidic

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Laksmiani, Ni Putu Linda, I. Wayan Agus Widiantara, and Andrew Borneo Salian Pawarrangan. "Potency of moringa (Moringa oleifera L.) leaves extract containing quercetin as a depigmentation agent inhibiting the tyrosinase enzyme using in-silico and in-vitro assay." Pharmacia 69, no. (1) (2022): 85–92. https://doi.org/10.3897/pharmacia.69.e73132.

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Abstract:

Hyperpigmentation is a disorder of facial skin pigments due to an increase in the process of melanogenesis, which can cause a darkening of skin color. A flavonoid compound with potential as a skin-lightening agent is quercetin, commonly found in Moringa oleifera L. leaves. This study aims to determine quercetin's affinity and molecular mechanism on tyrosinase enzyme target proteins using an in-silico molecular docking method. Docking of quercetin with the tyrosinase enzyme produced a bond energy value of -7.08 kcal/mol. In comparison, the tropolone as a native ligand with the tyrosinase enzyme

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Sakao, Kozue, Hanako Saruwatari, Shohei Minami, and De-Xing Hou. "Hydroxyl Group Acetylation of Quercetin Enhances Intracellular Absorption and Persistence to Upregulate Anticancer Activity in HepG2 Cells." International Journal of Molecular Sciences 24, no. 23 (2023): 16652. http://dx.doi.org/10.3390/ijms242316652.

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Quercetin, a flavonoid compound widely distributed in many plants, is known to have potent antitumor effects on several cancer cells. Our previous study revealed that the acetylation of quercetin enhanced its antitumor effect. However, the mechanisms remain unknown. This study aimed to elucidate the bioavailability of acylated quercetin in the HepG2 cell model based on its antitumor effect. The positions of quercetin 3,7,3′,4′-OH were acetylated as 3,7,3′,4′-O-tetraacetylquercetin (4Ac-Q). The inhibitory effect of 4Ac-Q on HepG2 cell proliferation was assessed by measuring cell viability. The

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Jambor, Jerzy, and Lutosława Skrzypczak. "Flavonoids from the flowers of Nymphaea alba L." Acta Societatis Botanicorum Poloniae 60, no. 1-2 (2014): 119–25. http://dx.doi.org/10.5586/asbp.1991.010.

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Ten flavonoids were obtained from the flowers of <i>Nymphaea alba</i> L. Their structures were determined mainly on the basis of spectral analyses (UV, 'H NMR, MS). The following aglycons were isolated: quercetin, kaempferol, isokaempferide and apigenin as well as the following glycosides: quercetion 4'-β-xyloside, 3-methylquercetin 3'-β-xyloside and a mixture of quercetin 3-galactoside and 3-glucoside. The structures of three compounds obtained in very small amounts were determined in part.

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Xu, Baoyang, Wenxia Qin, Yunzheng Xu, et al. "Dietary Quercetin Supplementation Attenuates Diarrhea and Intestinal Damage by Regulating Gut Microbiota in Weanling Piglets." Oxidative Medicine and Cellular Longevity 2021 (December 13, 2021): 1–19. http://dx.doi.org/10.1155/2021/6221012.

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Antioxidant polyphenols from plants are potential dietary supplementation to alleviate early weaning-induced intestinal disorders in piglets. Recent evidences showed polyphenol quercetin could reshape gut microbiota when it functioned as anti-inflammation or antioxidation agents in rodent models. However, the effect of dietary quercetin supplementation on intestinal disorders and gut microbiota of weanling piglets, along with the role of gut microbiota in this effect, both remain unclear. Here, we determined the quercetin’s effect on attenuating diarrhea, intestinal damage, and redox imbalance

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Arsito, Puguh Novi, Rima Erviana, Galih Titisari Kharismawati та Uki Wulanggita. "Multitarget Neuroprotective Effects of Quercetin on the Pathogenesis of Amyloid-β_1-42 in Alzheimer’s Disease: In-vitro and In-silico study". BIO Web of Conferences 135 (2024): 01004. http://dx.doi.org/10.1051/bioconf/202413501004.

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Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive impairment and neuronal death. The pathophysiology of AD includes cholinergic nerve damage, neuroinflammation, oxidative stress, and misfolding of amyloid-beta protein (Aβ). Current AD drug development focuses on a single target, whereas the AD mechanism is multifactorial, originating from the Aβ cascade, so intervention in Aβ is necessary. Flavonoid compounds are known to have many neuroprotective activities. Quercetin, an easily found flavonoid, can be used against AD. This research aimed to evaluate querceti

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Fauzi, Muhammad, Laela Hayu Nurani, Dwi Utami, and Lalu Muhammad Irham. "Quercetin: Synthesis Trends, Chemical Reactions, and Its Role as an Estrogen Receptor Alpha Modulator in Breast Cancer Therapy: A Systematic Literature Review." Trends in Sciences 22, no. 8 (2025): 9423. https://doi.org/10.48048/tis.2025.9423.

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Quercetin, a flavonoid abundant in fruits and vegetables, has garnered significant attention for its therapeutic potential in breast cancer treatment. Despite its promising bioactivity, clinical applications of quercetin remain limited due to challenges in synthesis, structural stability, and bioavailability. This systematic review examines recent advancements in quercetin synthesis through diverse chemical reactions aimed at improving efficiency and pharmacological properties. Key strategies such as the Algar-Flynn-Oyamada reaction, regioselective esterification, and glycosylation are discuss

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Nguyen, Thi Lan Anh, and Debanjana Bhattacharya. "Antimicrobial Activity of Quercetin: An Approach to Its Mechanistic Principle." Molecules 27, no. 8 (2022): 2494. http://dx.doi.org/10.3390/molecules27082494.

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Quercetin, an essential plant flavonoid, possesses a variety of pharmacological activities. Extensive literature investigates its antimicrobial activity and possible mechanism of action. Quercetin has been shown to inhibit the growth of different Gram-positive and Gram-negative bacteria as well as fungi and viruses. The mechanism of its antimicrobial action includes cell membrane damage, change of membrane permeability, inhibition of synthesis of nucleic acids and proteins, reduction of expression of virulence factors, mitochondrial dysfunction, and preventing biofilm formation. Quercetin has

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Ragunath, Ravichandiran, Bichandarkoil Jayaram Pratima, Briska Jifrina Premnath, and Namasivayam Nalini. "Quercetin Prevents Bisphenol S Induced Behavioral Changes and Oxidative Stress iZebrafish by Modulating Brain Antioxidant Defense Mechanism." Biosciences Biotechnology Research Asia 19, no. 3 (2022): 589–600. http://dx.doi.org/10.13005/bbra/3012.

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ABSTRACT: The man-made xenoestrogen bisphenol S has been well-established and associated with developing neoplasm, dementia, neurotoxicity, anxiety, and other adverse effects in people and other organisms. The mechanisms of BPS-induced toxicity have been studied; however, it is unclear if there is any prospect for improvement by natural means. After being exposed to BPS through water, zebrafish (Danio rerio) were employed in this investigation to determine whether quercetin co-supplementation could lessen the compound's destructive potential. Laboratory tests were done to see if quercetin's an

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