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Journal articles on the topic 'QuickTime'

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Published: 4 June 2021

Last updated: 4 March 2023

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1

Ishimaru, T., D. Lew, and F. Shinozaki. "Temporomandibular joint virtual arthroscopy: QuickTime and QuickTime VR movies0." International Journal of Oral and Maxillofacial Surgery 28 (January 1999): 173. http://dx.doi.org/10.1016/s0901-5027(99)81133-3.

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Balogh, Attila, Mark C. Preul, Mark Schornak, Michael Hickman, and Robert F. Spetzler. "Intraoperative stereoscopic QuickTime Virtual Reality." Journal of Neurosurgery 100, no. 4 (2004): 591–96. http://dx.doi.org/10.3171/jns.2004.100.4.0591.

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Object. The aim of this study was to acquire intraoperative images during neurosurgical procedures for later reconstruction into a stereoscopic image system (QuickTime Virtual Reality [QTVR]) that would improve visualization of complex neurosurgical procedures. Methods. A robotic microscope and digital cameras were used to acquire left and right image pairs during cranial surgery; a grid system facilitated image acquisition with the microscope. The surgeon determined a field of interest and a target or pivot point for image acquisition. Images were processed with commercially available software and hardware. Two-dimensional (2D) or interlaced left and right 2D images were reconstructed into a standard or stereoscopic QTVR format. Standard QTVR images were produced if stereoscopy was not needed. Intraoperative image sequences of regions of interest were captured in six patients. Relatively wide and deep dissections afford an opportunity for excellent QTVR production. Narrow or restricted surgical corridors can be reconstructed into the stereoscopic QTVR mode by using a keyhole mode of image acquisition. The stereoscopic effect is unimpressive with shallow or cortical surface dissections, which can be reconstructed into standard QTVR images. Conclusions. The QTVR system depicts multiple views of the same anatomy from different angles. By tilting, panning, or rotating the reconstructed images, the user can view a virtual three-dimensional tour of a neurosurgical dissection, with images acquired intraoperatively. The stereoscopic QTVR format provides depth to the montage. The system recreates the dissection environment almost completely and provides a superior anatomical frame of reference compared with the images captured by still or video photography in the operating room.

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Zou, Xueli. "Conductors and Insulators: A QuickTime Movie." Physics Teacher 43, no. 7 (2005): 460–62. http://dx.doi.org/10.1119/1.2060647.

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Huff, J. S. "QuickTime Movies on the QT: Creating a Lecture Movie Gallery Inexpensively Using PowerPoint and QuickTime Pro." Academic Emergency Medicine 9, no. 10 (2002): 1058—b—1058. http://dx.doi.org/10.1197/aemj.9.10.1058-b.

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Schlimmer, J. C., and L. A. Hermens. "Software Agents: Completing Patterns and Constructing User Interfaces." Journal of Artificial Intelligence Research 1 (November 1, 1993): 61–89. http://dx.doi.org/10.1613/jair.25.

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To support the goal of allowing users to record and retrieve information, this paper describes an interactive note-taking system for pen-based computers with two distinctive features. First, it actively predicts what the user is going to write. Second, it automatically constructs a custom, button-box user interface on request. The system is an example of a learning-apprentice software- agent. A machine learning component characterizes the syntax and semantics of the user's information. A performance system uses this learned information to generate completion strings and construct a user interface. Description of Online Appendix: People like to record information. Doing this on paper is initially efficient, but lacks flexibility. Recording information on a computer is less efficient but more powerful. In our new note taking softwre, the user records information directly on a computer. Behind the interface, an agent acts for the user. To help, it provides defaults and constructs a custom user interface. The demonstration is a QuickTime movie of the note taking agent in action. The file is a binhexed self-extracting archive. Macintosh utilities for binhex are available from mac.archive.umich.edu. QuickTime is available from ftp.apple.com in the dts/mac/sys.soft/quicktime.

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Cochrane, Thomas. "Developing interactive multimedia Learning Objects using QuickTime." Computers in Human Behavior 23, no. 6 (2007): 2596–640. http://dx.doi.org/10.1016/j.chb.2006.08.007.

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Whitenack, Joy W., Nancy Knipping, Sue Novinger, Linda Coutts, and Barbara Reys. "Promising Research, Programs, and Projects: Using Technology to Foster Teachers’ Reflections about Children's Arithmetical Thinking." Teaching Children Mathematics 4, no. 8 (1998): 484–87. http://dx.doi.org/10.5951/tcm.4.8.0484.

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Twenty-eight primary-grade teachers, working in pairs, stared intently at the screens of their computers as they watched a CD-ROM containing QuickTime movie excerpts of students responding to mathematical tasks during an interview.

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Sako, Y., K. Fujimura, M. B. McDonald, and D. James. "A system for generating virtual seeds." Scientia Agricola 55, spe (1998): 39–45. http://dx.doi.org/10.1590/s0103-90161998000500007.

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Seed analysts need to identify seeds, and seed catalogs are used as a reference to accomplish this task. Conventional seed catalogs supply two-dimensional photographs and hand-drawn diagrams. In this study, a new, three-dimensional representation of seeds is developed to supplement these traditional photographs and drawings. QuickTime VR is a promising method for viewing three-dimensional objects on a computer screen. It permits manipulation of an object by rotating and viewing it from any pre-specified angle at an interactive speed, allowing the viewer the sense of examining a hand-held object. In this study, QuickTime VR object movies of seeds were created as interactive "movies" of seeds that can be rotated and scaled to give the viewer the sensation of examining actual seeds. This approach allows the examination of virtual seeds from any angle, permitting more accurate identification of seeds by seed analysts.

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WOOSLEY, J. "Creating interactive pathology tutorials in QuickTime and Flash." Human Pathology 37, no. 8 (2006): 974–77. http://dx.doi.org/10.1016/j.humpath.2006.03.012.

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Roth, Charles, та Ted Hickman. "Quicktime ℳ: A compression technology with expansive educational promise". TechTrends 37, № 4 (1992): 26–27. http://dx.doi.org/10.1007/bf02761391.

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Zhu, Yongyong. "QuickTime Virtual Reality Technology Applies to Practical Teaching Recording System." International Journal of Online Engineering (iJOE) 9, no. 5 (2013): 4. http://dx.doi.org/10.3991/ijoe.v9i5.2606.

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Menduni, Enrico. "Four steps in innovative radio broadcasting: From QuickTime to podcasting." Radio Journal:International Studies in Broadcast & Audio Media 5, no. 1 (2007): 9–18. http://dx.doi.org/10.1386/rajo.5.1.9_1.

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Anderson, Jay Martin. "Algorithm visualization using QuickTime movies for student interaction (poster session)." ACM SIGCSE Bulletin 32, no. 3 (2000): 185. http://dx.doi.org/10.1145/353519.343182.

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TOKITA, Sumio, Takao SUGIYAMA, Tomotsugu KONDO, and Takeshi KIKUKAWA. "Interactive Animation of Hydrogen Atomic Orbitals Using QTVR(QuickTime Virtual Reality)." Journal of Chemical Software 5, no. 3 (1999): 129–36. http://dx.doi.org/10.2477/jchemsoft.5.129.

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TOKITA, Sumio. "A Novel Animation of Atomic Orbitals Using QTVR (QuickTime Virtual Reality)." Journal of Computer Aided Chemistry 1 (2000): 68–75. http://dx.doi.org/10.2751/jcac.1.68.

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Bush, Charles D. "Three visits to Montevidisco: Spanish enrichment with interactive videodisc." ReCALL 6, no. 2 (1994): 14–17. http://dx.doi.org/10.1017/s0958344000003189.

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Montevidisco is an interactive videodisc application intended for intermediate Spanish students. It combines language enrichment with elements of role-playing games as the student plays the role of someone visiting a hypothetical city in Mexico, interacting with native Spanish speakers in native situations via videodisc. The concept originated at Brigham Young University in the early eighties, with the video filming done at that time. More recently, the BYU Humanities Research Center has adapted the original material to run on standard microcomputer platforms.There are three implementations of Montevidisco in various stages of development. The first is a side-by-side version that uses a HyperCard stack on a Macintosh to control a separate videodisc player and monitor. The second version uses a video overlay configuration with ToolBook and Windows on an IBM platform. Both of these versions are 'finished' to the extent that they are being used in intermediate Spanish classes at BYU and elsewhere. General marketing arrangements are expected to be finalized this summer. The most recent implementation uses QuickTime on a Macintosh to display digitized video directly from the computer's hard disk.This paper begins with an explanation of the general features of Montevidisco that are common to all three implementations. It outlines some of the design considerations faced and explains how the choice of metaphor influenced those decisions. Some questions that have been raised during the testing and review process are also addressed. The paper then categorizes the significant differences between the three implementations and discusses the technological and pedagogical reasons for them. It concludes with a status report on the QuickTime version and gives an assessment of this new digital video technology in an instructional environment.

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Huff, J. S. "02 QuickTime Movies from PowerPoint Redux: Improvements in Creating an Online Lecture Gallery." Academic Emergency Medicine 10, no. 8 (2003): 915—b—915. http://dx.doi.org/10.1197/aemj.10.8.915-b.

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Zito, Francesco Alfredo, Franco Marzullo, Diego D'Errico, et al. "Quicktime virtual reality technology in light microscopy to support medical education in pathology." Modern Pathology 17, no. 6 (2004): 728–31. http://dx.doi.org/10.1038/modpathol.3800113.

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Oikonomou, Andreas, Saad Amin, Raouf N. G. Naguib, Alison Todman, and Hassanein Al-Omishy. "Interactive Reality System (IRiS): Interactive 3D Video Playback in Multimedia Applications." Journal of Advanced Computational Intelligence and Intelligent Informatics 10, no. 2 (2006): 145–49. http://dx.doi.org/10.20965/jaciii.2006.p0145.

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We developed a novel interactive video recording and playback technique for biomedical multimedia training but also applicable to other areas of multimedia. The Interactive Reality System (IRiS) improves on video playback used in most multimedia applications by controlling not only time, as in conventional video playback, but also space. A prototype is being tested and evaluated for multimedia training in breast self-examination (BSE). We discuss the advantages of IRiS and compare it to other similar approaches, such as QuickTime and iPIX. We detail the design of IRiS, its development, refinement, final implementation, evaluation, some projected plans and its uses in other biomedical and multimedia training scenarios.

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Carlberg, Ulf. "Review: Insects - a World of Diversity." Entomologica Fennica 6, no. 1 (1995): 42. http://dx.doi.org/10.33338/ef.83838.

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Commonwealth Scientific Industrial Research Organization (Ed.) 1994: Insects- a World of Diversity. - C.S.I.R.O., Information Services, 314 Albert Street, East Melbourne, Victoria 3002, Australia. CDROM Version 1.0 and printed Teachers' Guide, 104 pp (A4 size, alternatively spiralbound 17.5 x 24.5 em). CD-ROM available for both Windows and Macintosh versions. System requirements: Windows: IBM-compatibel computer 386-33 or faster, super VGA video card and monitor; 4Mb of RAM, Microsoft Windows 3.1 or later, Microsoft Windows compatible digital audio card and CD-ROM drive. Macintosh: Apple Macintosh computer, 13 inch colour monitor (or larger), 4Mb of RAM, CD-ROM drive and Quicktime 1.6 or later(providedonCD).Price: CD-ROM: AUD 109.-,CD-ROMandTeachers' GuideAUD 129.-.

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Mansfield, John F. "Quicktime as a Storage Medium for Dynamic Data Sets in In-Situ Electron Microscopy." Microscopy and Microanalysis 4, S2 (1998): 4–5. http://dx.doi.org/10.1017/s1431927600020146.

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The field of in-situ electron microscopy has recently become very active. Microscopy and Microanalysis 1997 was host to an extended symposium devoted entirely to in-situ studies. Also, a recent Winter School sponsored by Arizona State University was devoted entirely to in-situ electron microscopy and drew over 90 attendees. Examination of the presentations and papers in these in-situ symposia has revealed that the researchers involved still have problems acquiring, managing and storing and manipulating their data. An in-situ experiment, by its very nature, is dynamic and recording micrographs is typically not the optimum method of image acquisition. Videotape is the preferred medium. High grade S-video recording of experiments permits the extraction of single frames of reasonable quality from the tapes for presentation and publication. There are, however, a number of problems with video recording. During in-situ studies a number of variables in the sample environment are changing, e.g. the pressure, the temperature, the stress, the strain and the microscope parameters (accelerating voltage, beam current, magnification, specimen tilt, etc.).

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Cohen, Michael, Noor Alamshah Bolhassan, and Owen Noel Newton Fernando. "A Multiuser Multiperspective Stereographic QTVR Browser Complemented by Java3D Visualizer and Emulator." Presence: Teleoperators and Virtual Environments 16, no. 4 (2007): 414–38. http://dx.doi.org/10.1162/pres.16.4.414.

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To support multiperspective and stereographic image display systems intended for multiuser applications, we have developed two integrated multiuser multiperspective stereographic browsers, respectively featuring IBR-generated egocentric and CG exocentric perspectives. The first one described, “VR4U2C” (‘virtual reality for you to see’), uses Apple's QuickTime VR technology and the Java programming language together with the support of the QuickTime for Java library. This unique QTVR browser allows coordinated display of multiple views of a scene or object, limited only by the size and number of monitors or projectors assembled around or among users (for panoramas or turnoramas) in various viewing locations. The browser also provides a novel solution to limitations associated with display of QTVR imagery: its multinode feature provides interactive stereographic QTVR (dubbed SQTVR) to display dynamically selected pairs of images exhibiting binocular parallax, the stereoscopic depth percept enhanced by motion parallax from displacement of the viewpoint through space coupled with rotation of the view through a 360° horizontal panorama. This navigable approach to SQTVR allows proper occlusion/disocclusion as the virtual standpoint shifts, as well as natural looming of closer objects compared to more distant ones. We have integrated this stereographic panoramic browsing application in a client/server architecture with a sibling client, named “Just Look at Yourself!” which is built with Java3D and allows realtime visualization of the dollying and viewpoint adjustment as well as juxtaposition and combination of stereographic CG and IBR displays. “Just Look at Yourself!” visualizes and emulates VR4U2C, embedding avatars associated with cylinder pairs wrapped around the stereo standpoints texture-mapped with a set of panoramic scenes into a 3D CG model of the same space as that captured by the set of panoramas. The transparency of the 3D CG polygon space and the photorealistic stereographic 360° scenes, as well as the size of the stereo goggles through which the CG space is conceptually viewed and upon which the 360° scenes are texture-mapped, can be adjusted at runtime to understand the relationship of the spaces.

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ross, nigel j. "ms and the eu: naming a non-starter." English Today 21, no. 4 (2005): 36–38. http://dx.doi.org/10.1017/s0266078405004086.

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the eu recently forced microsoft to issue a second version of its windows xp operating system without a built-in windows media player, ruling that, by bundling its own media player, microsoft was effectively blocking competition from rivals (particularly real player and quicktime). microsoft's monopolistic approach in this case also landed it a fine of €497.2 million ($665m). the wrangling lasted well over a year, during which time windows xp with bundled media player had been sold so widely in europe as to partly invalidate the eu's attempts at stopping the us company monopolising and controlling the market. ‘the second version of windows will reflect what consumers want, and not what microsoft imposes on them,’ was the triumphant but belated comment of mario monti, the former eu commissioner in charge of competition.

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Nieder, Gary L., Jane N. Scott, and Mark D. Anderson. "Using QuickTime virtual reality objects in computer-assisted instruction of gross anatomy:Yorick?the VR Skull." Clinical Anatomy 13, no. 4 (2000): 287–93. http://dx.doi.org/10.1002/1098-2353(2000)13:4<287::aid-ca9>3.0.co;2-l.

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Carmichael, Stephen W. "Observing Traffic Within Cells." Microscopy Today 5, no. 8 (1997): 3–4. http://dx.doi.org/10.1017/s1551929500056704.

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Ever since membranes could be resolved within cells, the pattern of intracellular membrane trafficking has been under investigation. Images made with the transmission electron microscope revealed numerous small vesicles that appeared to be shuttling between the endoplasmic rettculum (ER) and the Golgi complex. However, these static images offered no information as to the direction trie vesicles were moving and were quite inconclusive. Nevertheless, evidence built over time to suggest that unrefined proteins were moved in small vesicles from one intracellular compartment to another. Recently, a study by John Presley, Nelson Cole, Trina Schroer, Koret Hirschberg, Kristen Zaal, and Jennifer Lippincott- Schwartz with the light microscope has challenged this view. They not only presented convincing morphologic data in their published article, but they also posted some Quicktime movies on a Web site (http://dir.nichd.nih.gov/CBMB/pb1labob.html) that are even more convincing.

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Jáuregui, David V., and Kenneth R. White. "Implementation of Virtual Reality in Routine Bridge Inspection." Transportation Research Record: Journal of the Transportation Research Board 1827, no. 1 (2003): 29–35. http://dx.doi.org/10.3141/1827-04.

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The innovative use of QuickTime Virtual Reality (QTVR) and panoramic image–creation utilities for recording field observations and measurements during routine bridge inspections is reported. A virtual reality approach provides the ability to document a bridge’s physical condition by using different media types at a significantly higher level of detail than is possible in a written bridge inspection report. Digitally recorded data can be stored on compact disc for easy access before, during, or after an inspection. The development of a QTVR bridge record consists of four major steps: selection of the camera stations, acquisition of the digital images, creation of cylindrical or cubic panoramas, and rendering of the QTVR file. Specific details related to these steps are provided, as applied to various bridge inspection projects. The potential impact of QTVR on bridge management—in which routine inspection data are a factor in making decisions regarding the future maintenance, rehabilitation, or replacement of a bridge—is discussed.

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Richmond, Farley. "Kutiyattam: Marriage of an Ancient Art and the New Technology." Journal of Educational Technology Systems 24, no. 2 (1995): 165–71. http://dx.doi.org/10.2190/2w01-7ahb-af02-3xwy.

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This presentation traces the development of a multimedia program on Kutiyattam, the Sanskrit theatre of India, perhaps the world's oldest surviving genre of theatre. The program was designed and developed on HyperCard, including QuickTime movies, scanned slides and photographs, and sound. It includes many articles on the subject, as well as a devanagri text and English translation of the Hastalakshanadipika, an ancient Sanskrit manuscript regarded as the source of the gesture language of the actors. The application focuses on stylized gestures which are an essential part of the language of performance, unique patterns of chanting which represent a character's mood and emotions, physical exercises and massage that are used to develop an actor's stamina, discipline, and flexibility, eye exercises and facial expressions which permit performers to convey the deeper meaning of the performance text, and the musical accompaniment which shares an integral place in the performance event. It also identifies some of the notable advantages and disadvantages working with HyperCard.

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Yoshimura, Tadayosi, Yoshihiro F. Aoyama, Hideo Sakagami, and Yasuaki Sasamura. "Development of Multimedia Teaching Materials in Chemistry Education and the Educational Effect of Video Movie with QuickTime." Journal of Chemical Software 2, no. 3 (1995): 141–48. http://dx.doi.org/10.2477/jchemsoft.2.141.

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Trelease, Robert B., Gary L. Nieder, Jens Dørup, and Michael Schacht Hansen. "Going virtual with quicktime VR: New methods and standardized tools for interactive dynamic visualization of anatomical structures." Anatomical Record 261, no. 2 (2000): 64–77. http://dx.doi.org/10.1002/(sici)1097-0185(20000415)261:2<64::aid-ar6>3.0.co;2-o.

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Cochrane, Thomas. "Interactive QuickTime: Developing and Evaluating Multimedia Learning Objects to Enhance Both Face-To-Face and Distance E-Learning Environments." Interdisciplinary Journal of e-Skills and Lifelong Learning 1 (2005): 033–54. http://dx.doi.org/10.28945/409.

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Lim, Chen Kim, Kian Lam Tan, and Abdullah Zawawi bin Haji Talib. "Low-Cost Methods for Generating Panoramic Views for a Mobile Virtual Heritage Application and its Application to the Heritage Zone of George Town Malaysia." International Journal of E-Entrepreneurship and Innovation 2, no. 4 (2011): 58–73. http://dx.doi.org/10.4018/jeei.2011100105.

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With rapid advancement of technology, people can roam around the virtual world through the aid of the Internet. One of these advances is a photographic technique called panoramic view where the images are captured with elongated field of view using specialized software or equipments. One popular software for generating panoramic views is Apple Inc.’s QuickTime VR (QTVR). However, iphone Operating System (iOS) does not support the existing QTVR software. Therefore, a low-cost method for generating panoramic views on mobile platform is proposed. The proposed method is to store finite images in an array in order to generate a 360o panoramic view from different angles of the heritage sites. This method can be supported various platforms and can be installed in any mobile device without using intermediate software to convert the image file format. The key aspects of the iOS User Experience (UX) are also explored from the perspectives of Model-View-Control (MVC) strategies. The outcome is 360o cylindrical panoramic views that allow the user to gain a clear vision around historical monuments with standardize iOS interface design on a mobile platform using lower computational cost but with similar quality of production. The results of the evaluation have shown that the application is successfully implemented in George Town, Malaysia.

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Schlachetzki, Felix, Thilo Hölscher, O. W. Ullrich, et al. "Dynamic and three-dimensional transcranial sonography studies of an asymptomatic, cerebral convexity arachnoid cyst." Neurosurgical Focus 7, no. 6 (1999): E12. http://dx.doi.org/10.3171/foc.1999.7.6.13.

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Dynamic and three-dimensional transcranial sonography (dTCS and 3D-TCCS) examinations are complementary, noninvasive methods used in the assessment and follow up of patients with cerebrospinal fluid (CSF) circulation disorders. A 16-year-old female patient who presented with a space-occupying, cerebral convexity arachnoid cyst and recurrent tension-type headache underwent examination for raised intracranial pressure (ICP) by using a standard color-coded duplex sonography system attached to a personal computer–based system for 3D data acquisition. Conventional TCS identified the outer arachnoid membrane of the cyst, which undulated freely after short rotation of the head (“headshake maneuver”). The undulation was documented as a QuickTime movie that is included with this article. A 3D dataset was acquired and, by using a multiplanar reformatting reconstruction algorithm, the authors obtained images with excellent resolution that corresponded to an initial magnetic resonance (MR) imaging study. No differences on dTCS and 3D-TCS were detectable at follow up 9 months later, indicating normal ICP and a stable, benign condition. The use of 3D-TCCS and dTCS ultrasonography may complement other diagnostic procedures such as MR imaging and, thus, can improve management and therapeutic strategies for patients with CSF circulation disorders. In this report the authors present evidence of the excellent fine resolution and exact reproducibility of reconstructed ultrasound image planes derived from 3D datasets and the additional biomedical information from dynamic imaging.

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Williams, Heather. "Choreography of song, dance and beak movements in the zebra finch (Taeniopygia guttata)." Journal of Experimental Biology 204, no. 20 (2001): 3497–506. http://dx.doi.org/10.1242/jeb.204.20.3497.

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SUMMARY As do many songbirds, zebra finches sing their learned songs while performing a courtship display that includes movements of the body, head and beak. The coordination of these display components was assessed by analyzing video recordings of courting males. All birds changed beak aperture frequently within a single song, and each individual’s pattern of beak movements was consistent from song to song. Birds that copied their father’s songs reproduced many of the changes in beak aperture associated with particular syllables. The acoustic consequences of opening the beak were increases in amplitude and peak frequency, but not in fundamental frequency, of song syllables. The change in peak frequency is consistent with the hypothesis that an open beak results in a shortened vocal tract and thus a higher resonance frequency. Dance movements (hops and changes in body or head position) were less frequent, and the distribution of dance movements within the song was not as strongly patterned as were changes in beak aperture, nor were the peaks in the distribution as strongly marked. However, the correlation between the positioning of dance movements within fathers’ and sons’ songs was striking, suggesting that the choreography of dance patterns is transmitted from tutor to pupil together with the song. A QuickTime movie of a courtship display used in this study can be found at: http://www.williams.edu/Biology/ZFinch/zfdance.html.

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Melín-Aldana, Héctor, Barbara Carter, and Debra Sciortino. "Documentation of Surgical Specimens Using Digital Video Technology." Archives of Pathology & Laboratory Medicine 130, no. 9 (2006): 1335–38. http://dx.doi.org/10.5858/2006-130-1335-dossud.

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Abstract Context.—Digital technology is commonly used for documentation of specimens in anatomic pathology and has been mainly limited to still photographs. Technologic innovations, such as digital video, provide additional, in some cases better, options for documentation. Objective.—To demonstrate the applicability of digital video to the documentation of surgical specimens. Design.—A Canon Elura MC40 digital camcorder was used, and the unedited movies were transferred to a Macintosh PowerBook G4 computer. Both the camcorder and specimens were hand-held during filming. The movies were edited using the software iMovie. Annotations and histologic photographs may be easily incorporated into movies when editing, if desired. Results.—The finished movies are best viewed in computers which contain the free program QuickTime Player. Movies may also be incorporated onto DVDs, for viewing in standard DVD players or appropriately equipped computers. The final movies are on average 2 minutes in duration, with a file size between 2 and 400 megabytes, depending on the intended use. Because of file size, distribution is more practical via CD or DVD, but movies may be compressed for distribution through the Internet (e-mail, Web sites) or through internal hospital networks. Conclusions.—Digital video is a practical, easy, and affordable methodology for specimen documentation, permitting a better 3-dimensional understanding of the specimens. Discussions with colleagues, student education, presentation at conferences, and other educational activities can be enhanced with the implementation of digital video technology.

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Bradley, Lucy, Leslie Towill, Jean Stutz, and Robert Roberson. "Conversion of Introductory Plant Biology Course and Lab to Web-Based Distance Ed Course." HortScience 41, no. 4 (2006): 1002D—1002. http://dx.doi.org/10.21273/hortsci.41.4.1002d.

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Conversion of the introductory plant biology course for non-majors from a lecture/lab format to a web-based course was a collaborative project between the Department of Plant Biology and the Instructional Support group at ASU. This course provides an introduction to biology through the world of plants by including lectures and laboratory activities that examine plant systems. The project was undertaken to provide students with an asynchronous opportunity to participate in either the course, the lab, or both. There were three distinct phases of implementation of the multimedia website: Design, Development, and Delivery. The design phase was driven by the faculty, who, along with graduate assistants, developed the course outline and content. They gathered images, identified concepts to be animated, and created storyboards to layout the sequence in the animation. The development stage was driven by the Instructional Designers who selected the appropriate media for animations and worked with developers to create them. The delivery phase was again driven by the professors. They implemented the website as a teaching tool, gathered feedback from students and teaching assistants, and worked with instructional designers and multimedia developers to improve the site. A wide variety of on-line multimedia components were incorporated into the website, including illustrations, images, animations, interactive modules, video and text. Three separate media packages were used: MacroMedia Flash (Macromedia, 2000), Director Shockwave (Macromedia, 2000), and QuickTime (Apple, Inc. 2000). Findings from surveys of students, faculty, and staff identified positive regard for the site as a whole. Several technological and logistical challenges were encountered and addressed.

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Beegle-Krause, J. "GENERAL NOAA OIL MODELING ENVIRONMENT (GNOME): A NEW SPILL TRAJECTORY MODEL." International Oil Spill Conference Proceedings 2001, no. 2 (2001): 865–71. http://dx.doi.org/10.7901/2169-3358-2001-2-865.

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ABSTRACT The General NOAA Oil Modeling Environment (GNOME) is a standard Eulerian/Lagrangian spill-trajectory model designed to meet the needs of planners and expert responders through three different user modes: Standard, GIS Output, and Diagnostic. Spills are modeled by Lagrangian Elements (LEs or splots) within continuous flow fields. GNOME supports the National Oceanic and Atmospheric Administration (NOAA)/Hazardous Materials Response Division (HAZMAT) standard for Best Guess and Minimum Regret trajectories by providing information about where the spill is most likely to go (Best Guess solution) and the uncertainty bound (Minimum Regret solution). The public, including spill responders, industry, and students, can use GNOME in Standard or GIS Output mode to prepare spill scenario-related products and for intuition building. These GNOME modes require a Location File that contains a regional trajectory model with a Mini-Expert System to aid in setting up the model. The Mini-Expert System sets up the trajectory model based on user input via dialog boxes. Information sources also are provided to help users answer the dialog questions. Responders can use GNOME's Diagnostic mode to quickly set up custom trajectory models for any area, as HAZMAT does during spill response. GNOME's Diagnostic model can accept circulation patterns from any hydrodynamic model (from two-dimensional steady-state to three-dimensional time-dependent models) with proper formatting. GNOME allows all users to save their work in files and create QuickTime movies. In GIS Output and Diagnostic modes, users can export the model results to GNOME Analyst to convert the data from LEs or splots to oil-concentration contours. Both the splots and contours can be exported to a GIS system (HAZMAT provides an ArcView extension). HAZMAT presently is creating Location Files for U.S. Coast Guard and NOAA priority locations with a design philosophy to allow users significant control over the model setup without requiring extensive spill modeling experience. GNOME, all Location Files, and documentation are available for download from NOAA's Office of Response and Restoration Web site1 under Aids for Oil Spill Responders.

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Heller, Stephen R. "Book Review of Inspired CSS: Styling for a Beautiful Web (Video)Inspired CSS: Styling for a Beautiful Web (Video) . By Andy Clarke . Peachpit Press : March 2008 . Online video in QuickTime format, duration 2h20m. U.S. $59.99. ISBN0-321-54562-1, 978-0-321-54562-6." Journal of Chemical Information and Modeling 48, no. 9 (2008): 1930. http://dx.doi.org/10.1021/ci8001843.

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Taylor, Ronald P., Paul V. Beum, Andrew W. Pawluczkowycz, et al. "Spinning Disk Confocal Fluorescent Microscopy (SDCFM) Analyses of Complement Activation Promoted by Anti-CD20 Monoclonal Antibodies (mAbs) Rituximab and Ofatumumab." Blood 110, no. 11 (2007): 2345. http://dx.doi.org/10.1182/blood.v110.11.2345.2345.

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Abstract We examined the real-time dynamics of complement activation on CD20-positive cells, promoted by binding of two different anti-CD20 mAbs, rituximab and ofatumumab. Daudi and ARH77 cells were opsonized with Alexa-labeled anti-CD20 mAbs, mixed with normal human serum (NHS) and immediately analyzed by SDCFM at 37°C. Multiple fluorescent image Z stacks were captured over 2–10 min, and Quicktime™ movies generated. Deposition of C3b fragments was monitored with Alexa-labeled mAb 3E7 in situ, specific for cell-bound C3b/iC3b. Complement activation mediated by the mAbs induced profound effects on the cells. C3b deposition was readily demonstrable and substantial changes in morphology including rapid blebbing were evident. Most strikingly, long string-like structures were cast off the cells. These mAb-induced streamers were seen in both NHS and in citrated plasma, but were not generated if complement-mediated killing was precluded, e.g. in C5-deficient NHS or in NHS-EDTA. The streamers appear to be quite fragile and were not observed if cells were subjected to a centrifugation step. In 2-color and 3-color experiments using propidium iodide (PI), cell death was easily seen as PI entered the cells. The streamers also stained positive with phalloidin, and streaming was largely abrogated with cytochalasin D, suggesting that the streamers contained polymerized actin. Movies made under white light conditions also revealed streamers, suggesting that cell-derived fragments, most likely originating at the cell membrane, were being extruded as a consequence of penetration of the cells by the pore-forming membrane attack complex (MAC) of complement. Although not all cells that were killed also produced streamers, the production of streamers, presumably indicative of attack by the MAC, tended to correlate with subsequent killing. In fact, another reagent known to lyse cells based on insertion of a different pore-forming complex, melittin, also induced streamers in these cells. Direct comparisons between rituximab and ofatumumab revealed several interesting differences. Ofatumumab readily promoted complement activation, C3b deposition, and killing of ARH77 cells, but rituximab-mediated C3b deposition was lower, and killing was close to background. In addition, maximum deposition of C3b fragments on ARH77 cells occurred considerably more rapidly for ofatumumab (∼ 30 sec) than for rituximab (∼ 5 min). Consistent with these findings, binding of ofatumumab to ARH 77 cells in NHS induced blebbing and generated streamers to a much greater degree (5 to 10-fold more) than seen for cells opsonized with rituximab and NHS. Moreover, for Daudi cells that were opsonized with the mAbs on ice and then reacted with NHS and placed at 37°C, ofatumumab induced streaming in ∼ 2 min, but rituximab-mediated streaming was not evident until at least 10 min. In summary, SDCFM allows for real time analysis of several distinct steps in mAb-mediated complement activation and killing of targeted cells. Our results indicate that binding of ofatumumab to CD20-positive cells rapidly activates complement and produces profound changes in the cells, including the generation of streamers followed by cell death, in periods of 5 minutes or less.

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Charlton, Amanda, and Diane Kenwright. "Getting started with screen recording." Pacific Journal of Technology Enhanced Learning 2, no. 1 (2019): 15–16. http://dx.doi.org/10.24135/pjtel.v2i1.33.

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Overview Ever watched a YouTube video to solve a software problem? For example, ‘How do I set up Presenter View in PowerPoint? Well, you are watching a screen recording, also known as screencasting and video screen capture. This is a video recording with audio narration; not to be confused with screenshot/capture, which is a still photo. For educators, screen recording is ideal for: recording your presentations in a controlled environment, recording feedback on student work with real teacher presence, explaining course and LMS navigation, explaining and annotating images such as digital microscopy, radiology, graphics, as well as recording a digital whiteboard for hand drawn mathematics equations or diagrams.  Outcomes At the end of this 90 min mini workshop you will have created and shared your first screen recorded video, and will be able to do it again.  Major features to be investigated Structured into 6 steps, discussion and demonstration of pros and cons of  Hardware – laptop/desktop vs mobile device Software – free vs paid Microphone – inbuilt vs USB Recording technique – record/pause segments Upload -video hosting Share - links   Session organisation     5 tables. 4 participants per table. Maximum 20 participants. Mac users grouped together, and Windows users grouped together     Time (mins)   Activity   Content     10   Icebreaker   Table group introductions, share experience with screen recording and intended uses, table group discussion and whole group Post-it notes .     10   Demonstration   Introduction and use cases. Downloading software.     15   Pair programming   Participants access free software. Windows users: Screencast-o-matic or Zoom Mac users: QuickTime     10   Demonstration and printed set up sheet   Settings for video, webcam, audio. Recording tips and techniques.     15   Individuals or pairs    Set up software, and microphone. Open one of your previous PowerPoint presentations or other resource, make a 2 sec recording of desktop screen.     5      Break     10   Demonstration   Save, upload, share     15    Pairs   Participants create a 1 min video, save and upload, share link by email with partner. Self critique and partner feedback using a structured framework.     5   Discussion   Revisit how you might use screen recording in your teaching. Table group discussion and Post-it notes.     5   Evaluation Survey   QR code to online survey on phone Resource links.      Resources for distribution We will be using free software, either inbuilt or accessed online. One page printed step by step guide.  Expectations and requirements of participants You need to bring your own laptop to participate, or pair with someone who has. Although screen recording is possible on a tablet or phone, you will have to install different Apps.

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Howe, K., A. Bateman, and R. Durbin. "QuickTree: building huge Neighbour-Joining trees of protein sequences." Bioinformatics 18, no. 11 (2002): 1546–47. http://dx.doi.org/10.1093/bioinformatics/18.11.1546.

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Tindle, Andy. "CHRISTIANSEN, E. H. 2001. PetroGlyph 1.0. Interactive virtual microscope program for PC and Mac (minimum requirements: Windows 95 or higher; MacOS 7.5 or higher; QuickTime 4.0; 1000 colours; CD-ROM drive; 30 MB free RAM; 225 MB free disk). Oxford, Malden MA: Blackwell Science. Price £24.50. ISBN 0 632 04532 9." Geological Magazine 138, no. 5 (2001): 619–30. http://dx.doi.org/10.1017/s0016756801306088.

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Morell, Alexis, Daniel Eichberg, Ashish Shah, et al. "CNTM-01. Evaluating Traditional and Non-Traditional Eloquent Areas in Patients with Brain Tumors: Large-scale Network Analysis Using a Machine Learning-Based Platform." Neuro-Oncology 23, Supplement_6 (2021): vi224. http://dx.doi.org/10.1093/neuonc/noab196.899.

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Abstract BACKGROUND Developing mapping tools that allow identification of traditional or non-traditional eloquent areas is necessary to minimize the risk of postoperative neurologic deficits. The objective of our study is to evaluate the use of a novel cloud-based platform that uses machine learning to identify cerebral networks in patients with brain tumors. METHODS We retrospectively included all adult patients who underwent surgery for brain tumor resection or thermal ablation at our Institution between the 16th of February and the 15th of May of 2021. Pre and postoperative contrast-enhanced MRI with T1-weighted and high-resolution Diffusion Tensor Imaging (DTI) sequences were uploaded into the Quicktome platform. After processing the data, we categorized the integrity of seven large-scale brain networks: sensorimotor, visual, ventral attention, central executive, default mode, dorsal attention and limbic. Affected networks were correlated with pre and postoperative clinical data, including neurologic deficits. RESULTS Thirty-five (35) patients were included in the study. The average age of the sample was 63.2 years, and 51.4% (n=18) were females. The most affected network was the central executive network (40%), followed by the dorsal attention and default mode networks (31.4%), while the least affected were the visual (11%) and ventral attention networks (17%). Patients with preoperative deficits showed a significantly higher number of altered networks before the surgery (p=0.021), compared to patients without deficits. In addition, we found that patients without neurologic deficits had an average of 2.06 large-scale networks affected, with 75% of them not being related to traditional eloquent areas as the sensorimotor, language or visual circuits. CONCLUSIONS The Quicktome platform is a practical tool that allows automatic visualization of large-scale brain networks in patients with brain tumors. Although further studies are needed, it may assist in the surgical management of traditional and non-traditional eloquent areas.

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Zhou, Haofeng, Denys Baskov, and Matthew Lease. "Crowdsourcing Transcription Beyond Mechanical Turk." Proceedings of the AAAI Conference on Human Computation and Crowdsourcing 1 (November 3, 2013): 9–16. http://dx.doi.org/10.1609/hcomp.v1i1.13093.

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While much work has studied crowdsourced transcription via Amazon’s Mechanical Turk, we are not familiar with any prior cross-platform analysis of crowdsourcing service providers for transcription. We present a qualitative and quantitative analysis of eight such providers: 1-888-Type-It-Up, 3Play Media, Transcription Hub, CastingWords, Rev, TranscribeMe, Quicktate, and SpeakerText. We also provide comparative evaluation vs. three transcribers from oDesk. Spontanteous speech used in our experiments is drawn from USC-SFI MALACH collection of oral history interviews. After informally evaluating pilot transcripts from all providers, our formal evaluation measures word error rate (WER) over 10-minute segments from six interviews transcribed by three service providers and the three oDesk transcribers. We report the WER obtained in each case, and more generally assess tradeoffs among the quality, cost, risk and effort of alternative crowd-based transcription options.

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Cox, C. S., P. R. Daniel, and A. Lowdon. "Quicktune: A Reliable Automatic Strategy for Determining PI and PPI Controller Parameters using a FOPDT Model." IFAC Proceedings Volumes 30, no. 3 (1997): 101–6. http://dx.doi.org/10.1016/s1474-6670(17)44474-0.

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Cox, C. S., P. R. Daniel, and A. Lowdon. "Quicktune: A reliable automatic strategy for determining PI and PPI controller parameters using a FOPDT model." Control Engineering Practice 5, no. 10 (1997): 1463–72. http://dx.doi.org/10.1016/s0967-0661(97)00144-5.

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Konneh, Mohamed, Mohammad Iqbal, Hanfi bin Ani, and Mohd Zulhari bin Yayah. "Influence of Machining Parameters on Temperature when Drilling Carbon Fiber Reinforced Polymer (CFRP) Using Coated Diamond Drills." Advanced Materials Research 1115 (July 2015): 74–79. http://dx.doi.org/10.4028/www.scientific.net/amr.1115.74.

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As the tendency towards weight reduction and low fuel consumption seems to drive the increased use of advanced exotic materials such as composites, titaniums and Inconels in the aerospace industry, the need for machining remains in aircraft industries as a post-processing operation. In the present work, the investigation of the influence of machining parameters on surface temperature when drilling CFRP using 4 mm-diameter 2-fluted carbide end-mill coated with diamond is presented. The temperature was examined on Thermal Gun Quicktemp 860-T1 sensor and analysed based on analysis of variance (ANOVA) of Central Composite Design of experiments and a first order mathematical model has been developed to predict temperature values for range of machining parameters used in the study. The relationship between the machining variables and output variables is established. It was found that the lowest temperature (32.2°C) was generated at rotational speed, 537 rpm and feed rate, 180 mm/min and at the highest temperature (39.1°C) generated at rotational speed, 4400 rpm and feed rate, 270 mm/min.

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Figueiredo, Eberval Gadelha, José Weber Vieira de Faria, Gerson Ballester, and Manoel Jacobsen Teixeira. "Quick-Time VRTM: when medical education meets virtual reality." Revista de Medicina 88, no. 3-4 (2009): 175–80. http://dx.doi.org/10.11606/issn.1679-9836.v88i3/4p175-180.

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Learning medicine is a difficult process to undertake, partially due to the complexity of the subject and limitations of traditional methods of teaching (lectures, textbooks, laboratory and anatomical dissections). These resources have been effective for decades, even though presenting intrinsic drawbacks. Textbooks are non-interactive education tools and do not provide any three dimensional experience. Cadaver dissection is an invaluable aid to learn anatomy. It provides an immersive, interactive experience allied with an inimitable tactile feedback. However, it has several limitations, including availability of specimens, costs and a substantial time commitment. Computer based virtual reality methods may overcome these drawbacks and provide interesting alternatives for medical training. Technological advances have generated great expectations for the use of computer-based virtual reality technologies in medical education, mainly anatomy and surgery. However, these Virtual Reality tools for general medical education are expensive due to the equipment necessary to create highly detailed, immersive three-dimensional image environments with real time friendly user interactivity. The concepts of Virtual Reality methods that generate immersive environments, as well as those that create simulated objects with interactive viewing features may be contemplated by the QuickTimeTM which is one of the technologies that can be successfully used for interactive, photorealistic displaying of medical images (radiological, anatomical and histological) and interaction on current generation of personal computers at a low and accessible cost. In this paper, the authors provide an overview of the Quick Time Virtual Reality methods aiming to introduce them to medical educators and illustrate their application on medical training.

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M.I., Abou-Dobara, El-Sawy E., and Altayyeb M. "Evaluation of the efficiency of URO-QUICKTM System in the Detection of Urinary Tract Infections and use of Fluorescence In-Situ Hybridization (FISH) In Detection of Escherichia coli in Urine." Egyptian Journal of Medical Microbiology 28, no. 3 (2019): 155–61. http://dx.doi.org/10.21608/ejmm.2019.283187.

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Beligaswatte, Ashanka M., Eleni Tsiopelas, Ian Humphreys, et al. "The Mean Fluorescence Intensities of Anti-HLA Antibodies Detected Using Micro-Bead Flow Cytometry Predict the Risk of Platelet Transfusion Refractoriness." Blood 120, no. 21 (2012): 2285. http://dx.doi.org/10.1182/blood.v120.21.2285.2285.

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Abstract Abstract 2285 Background: HLA allo-immunized patients often receive matched platelets only after demonstrating platelet transfusion refractoriness (PTR). If further risk stratification was possible, high risk patients could be considered for pre-emptive HLA-matched platelets, cryopreserved autologous platelets, or possibly thrombopoietin analogues. Micro-bead flow cytometry is widely used to detect anti-HLA antibodies, and mean fluorescence intensities (MFI) obtained from these assays correlate with antibody titers. We asked whether MFIs could be used to stratify the risk of PTR among allo-immunized patients. Study design: We retrospectively identified 387 patients who received an autologous stem cell transplant or induction therapy for acute leukemia, between January 2005 and March 2012. All patients had a serum sample taken for HLA antibody assay within 6 weeks of commencing cellular blood product transfusions. No patient was scheduled to receive prophylactic HLA matched platelets. The primary endpoint was the development of PTR. To minimize the influence of sensitization occurring after screening, only outcomes during the first 2 weeks from commencing cellular blood product transfusions were considered. PTR was defined as having received ≥ 2 consecutive RDPLT transfusions associated with an 18–24h corrected count increment of < 2.5 at 18 – 24 hours. Antibody testing was performed using a micro-bead flow cytometry assay (Lifecodes LifeScreen Deluxe, with positive results confirmed by Lifecodes Class I ID assay, Gen-Probe Transplant Diagnostics, Stamford, CT) either during the treatment period, or on serum samples stored at −30°C. Mean fluorescence intensities (MFI) were acquired using a Luminex 100 analyzer (Luminex Corporation, Austin, TX), and analyzed using Lifecodes Quicktype v2.5.5 (Gen-Probe Transplant Diagnostics, Stamford, CT). We defined the predictor variable avgMFI to be the average MFI of the 7 individual beads in the assay, weighted by whether the presence of antibodies was confirmed or not: where w = 1 if the presence of antibodies is confirmed, and 0 otherwise; and subscript i refers to the ith class I bead. Results: Antibodies were detected in 57 (14.7%) patients of whom 45 (78.9%) were female. A total of 1443 random donor platelet (RDPLT) transfusions (mean platelet count 2.4×1011/unit) were studied. Sixty six (17%) patients developed PTR, of whom 28 had detectable antibodies; 29 of 321 patients who did not develop PTR also tested positive. Among antibody positive patients, median avgMFI for refractory patients was 4589 versus 349 for patients who were not, Wilcoxon rank sum test P< 0.0001. (Figure 1). The area under the receiver operating characteristic curve for avgMFI as a predictor of PTR was 0.8633 (95% confidence interval: 0.7664 – 0.9602). Higher avgMFIs also correlated with a broader range of target antigens, likely due to increasingly avid binding to cross-reactive epitopes. (Spearman's r = 0.7736 for correlation between avgMFI and panel reactive antibody percentages (cPRA), calculated in reference to the general American population, and used here as a surrogate for the range of antibody specificities). cPRA was >80% in 25/27 patients with avgMFI>1000, suggesting poor ability to discriminate among patients with moderate to high antibody titers, and was not an independent predictor of PTR. Hence, while the increased probability of encountering a cognate antigen on a RDPLT may partly explain the correlation between avgMFI and PTR, the avidity of binding, represented in vitro by the MFIs, appears to be a more significant determinant of risk. In conclusion, we provide evidence for the concept that PTR risk due to HLA allo-immunization is usefully predicted by the MFIs of antibodies detected using micro-bead flow cytometry. Our model allows cut-offs for identifying high risk patients to be based on the degree of risk acceptable in a given clinical situation. This should enable hematology units to develop risk-adapted strategies for supporting allo-immunized thrombocytopenic patients. Disclosures: No relevant conflicts of interest to declare.

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Farrell, Katrina, Shauna Crae, Ann-Margaret Little, and Ruth F. Jarrett. "HLA-A*02:01 Is Associated with Inferior Overall Survival in EBV-Associated Classical Hodgkin Lymphoma." Blood 120, no. 21 (2012): 1526. http://dx.doi.org/10.1182/blood.v120.21.1526.1526.

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Abstract Abstract 1526 Introduction: The risk of developing Epstein-Barr Virus (EBV)-associated classical Hodgkin Lymphoma (cHL) shows an association with class I human leukocyte antigen (HLA) genes. HLA-A*01:01 is associated with increased risk of EBV-associated cHL whereas HLA-A*02:01 is associated with decreased risk. (Hjalgrim et. al, PNAS, 2010).The effects of these two alleles are independent of each other and the effect associated with each allele is additive i.e., possession of two HLA-A*01:01 alleles is associated with greater risk than one allele. HLA-A genes are involved in cytotoxic T cell (CTL) responses to exogenous antigens, and these data suggest that EBV-specific CTL responses are important in the pathogenesis of EBV-associated cHL. This study aimed to determine if HLA-A*01:01 and A*02:01 alleles are a factor in determining clinical outcome in EBV-associated cHL. Methods: Patients with cHL were selected from two previous studies: the Scotland and Newcastle Epidemiological Study of Hodgkin's disease (SNEHD) (Jarrett et. al, Blood, 2005) and the “Investigation of the pathogenesis of Hodgkin lymphoma” (IPHL), an ongoing collection of patients principally from the West of Scotland. Both studies have ethical approval. Clinical follow-up data were obtained through clinical records, liaison with treating physicians or the Scotland and Newcastle Lymphoma Group (SNLG) database. Clinical treatment decisions were made by individual physicians. Cases were selected on the basis of availability of tumour EBV status, a suitable sample for HLA typing and clinical follow-up data and included 257 cases from the SNEHD study and 128 from the IPHL. HLA genotyping was performed to an intermediate resolution using allele-specific PCR (Gen-probe) and subsequent bead-based sequence specific oligonucleotide (SSO) assay (Luminex). Allele assignment was performed using Quicktype for Lifematch software (Gen-probe). Results were analysed for all cases, EBV-associated cases only, and EBV-negative cases only. Overall survival (OS) and Event-free survival (EFS) were analysed by number of HLA-A*01:01 alleles, number of HLA-A*02:01 alleles, and by the presence or absence of HLA-A*01:01 or HLA-A*02:01. Statistical analyses used Kaplan-Meier survival and Cox-regression analyses, adjusting for histological subtype, clinical stage, age and sex, and were implemented using SPSS v.19. Results: 385 cases diagnosed between 1993 and 2008 were included in the analysis. 55.8% of cases were male and 128 (33.2%) had EBV-associated disease. Median follow up was 74 months (range 0–220 months). Clinical stage was available for 289 patients: stage 1 (17.9%); stage 2 (41.8%); stage 3 (22.5%); and stage 4 (17.6%). In the analysis of all cases there were no significant differences in OS and EFS by number or presence of HLA-A*02:01 and A*01:01 alleles. EBV-associated cHL cases demonstrated inferior OS with the presence of HLA-A*02:01 (p=0.04) (figure). This was corroborated by the demonstration of inferior OS with increasing number of HLA -A*02:01 alleles present (p=0.016). Increasing number of HLA -A*02:01 alleles was also associated with inferior EFS but differences were not statistically significant. HLA-A*01:01 was not associated with OS or EFS in EBV-associated cHL. There was no significant association between histological subtype and OS or EFS. When clinical stage, age, and sex were included in the Cox-regression analysis of survival in EBV-associated cases, only age (p<0.001) was significant; presence of an HLA-A*02:01 allele approached statistical significance (p =0.062). Conclusions: In this study the HLA-A*02:01 allele was associated with inferior survival in EBV-associated cHL. As HLA-A*02:01 is associated with a decreased risk of developing EBV-associated cHL, we hypothesise that cHL arising in this 'protected' group is associated with greater biological or immunological dysfunction, resulting in poorer outcome. HLA-A genotype may be helpful in identifying patients who have inferior outcomes using standard therapy, and who may benefit from novel or cellular therapies. Larger studies within the context of clinical trials are required to extend these findings. In addition, this study supports the importance of stratifying cHL cases by EBV-status in clinical studies. Disclosures: No relevant conflicts of interest to declare.

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