Log in

Relevant bibliographies by topics / Quinazolin-4-one derivative optimization

Contents

Journal articles

Academic literature on the topic 'Quinazolin-4-one derivative optimization'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Quinazolin-4-one derivative optimization.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Quinazolin-4-one derivative optimization"

1

Nilufar, Akhmedova, Burkhon Juraevich Elmuradov, and Foziljon Ergashevich Saitkulov. "OPTIMAL SYNTHESIS METHODS AND BIOLOGICAL ACTIVITY STUDY OF 2-(4-NITROPHENIL)QUINAZOLIN-4-ONE." Multidisciplinary Journal of Science and Technology 4, no. 12 (2024): 1192–200. https://doi.org/10.5281/zenodo.14566619.

Full text

Abstract:

The ideal synthesis techniques and the biological activity analysis of 2-(4-nitrophenyl)quinazolin-4-one are presented in this work. Electrophilic substitution processes were used to create the chemical, and several catalysts and solvents were used to optimize the reaction conditions. Using spectroscopic methods including Raman spectroscopy, the structure of the produced molecule was verified. The anthelmintic, antibacterial, antifungal, and cytotoxic qualities of 2-(4-nitrophenyl)quinazolin-4-one were assessed in terms of its biological activity. The findings show that this substance has a hi

APA, Harvard, Vancouver, ISO, and other styles

2

Ziyadullaev, Mirjalol E., Rixsibay K. Karimov, Gulnora V. Zukhurova, Asqar Sh Abdurazakov, and Shamansur Sh Sagdullaev. "SYNTHESIS OPTIMIZATION OF 6-NITRO-3,4-DIHYDROQUINAZOLINE-4-ONE." IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENII KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 63, no. 7 (2020): 48–53. http://dx.doi.org/10.6060/ivkkt.20206307.6145.

Full text

Abstract:

A method for the synthesis of the substance 6-nitro-3,4-dihydroquinazolin-4-one has been developed. Quantitative determination of the target product was carried out spectrophotometrically using an SF-46 instrument. As a solvent, 0.1 mol/l HCl was used. A 0.1 mol/l hydrochloric acid solution was used as a comparison solution. The optical density of the standard and test samples was measured at a wavelength of 254 nm. The synthesis conditions of 6-nitro-3,4-dihydro-quinazolin-4-one were studied. The structure of the obtained product was studied by IR, Mass, 1H, 13C NMR spectroscopy, and the stru

APA, Harvard, Vancouver, ISO, and other styles

3

El-Sayed, Nahed N. E., Taghreed M. Al-Otaibi, Mona Alonazi, et al. "Synthesis and Characterization of Some New Quinoxalin-2(1H)one and 2-Methyl-3H-quinazolin-4-one Derivatives Targeting the Onset and Progression of CRC with SRA, Molecular Docking, and ADMET Analyses." Molecules 26, no. 11 (2021): 3121. http://dx.doi.org/10.3390/molecules26113121.

Full text

Abstract:

The pathogenesis of colorectal cancer is a multifactorial process. Dysbiosis and the overexpression of COX-2 and LDHA are important effectors in the initiation and development of the disease through chromosomal instability, PGE2 biosynthesis, and induction of the Warburg effect, respectively. Herein, we report the in vitro testing of some new quinoxalinone and quinazolinone Schiff’s bases as: antibacterial, COX-2 and LDHA inhibitors, and anticolorectal agents on HCT-116 and LoVo cells. Moreover, molecular docking and SAR analyses were performed to identify the structural features contributing

APA, Harvard, Vancouver, ISO, and other styles

4

Fan, Yanhua, Fang Luo, Mingzhi Su, et al. "Structure optimization, synthesis, and biological evaluation of 6-(2-amino-1H-benzo[d]imidazole-6-yl)-quinazolin-4(3H)-one derivatives as potential multi-targeted anticancer agents via Aurora A/ PI3K/BRD4 inhibition." Bioorganic Chemistry 132 (March 2023): 106352. http://dx.doi.org/10.1016/j.bioorg.2023.106352.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Wu, Jinping, Peng Li, Yucheng Mu, et al. "Structural Optimization of Quinazolin-4-One Derivatives as Novel SARS-CoV-2 Mpro Inhibitors by Molecular Simulation." Letters in Drug Design & Discovery 21 (August 30, 2024). http://dx.doi.org/10.2174/0115701808330125240812104856.

Full text

Abstract:

Background: Severe acute respiratory syndrome coronavirus 2 main protease (SARSCoV- 2 Mpro) has been shown to be an effective target for inhibiting novel coronaviruses, which can be used as a crucial breakthrough for developing drugs to treat the coronavirus disease 2019 (COVID-19). Methods: To design novel SARS-CoV-2 Mpro inhibitors, we conducted 3D-QSAR, molecular docking, and molecular dynamics (MD) simulation on 64 quinazolin-4-one derivatives. Results: Comparative molecular field analysis (CoMFA) model (q2 = 0.590, R2 = 0.962), comparative molecular similarity index analysis (CoMSIA) mode

APA, Harvard, Vancouver, ISO, and other styles

6

Sulthana, M. T., V. Alagarsamy, and K. Chitra. "Design, Synthesis, Pharmacological evaluation, in silico modeling, prediction of toxicity and metabolism studies of novel 1-(substituted)-2-methyl-3-(4-oxo-2-phenyl quinazolin-3(4H)-yl)isothioureas." Medicinal Chemistry 16 (August 17, 2020). http://dx.doi.org/10.2174/1573406416666200817153033.

Full text

Abstract:

Background: Although exhaustive efforts to prevent and treat tuberculosis (TB) was taken the problem still continues due to multi-drug-resistant (MDR) and extensively drug resistant TB (XDR-TB). It clearly highlights the urgent need to develop novel “druggable” molecules for the co-infection treatment and strains of MDR-TB and XDR-TB. Objective: In this approach a hybrid molecule was created by merging two or more pharmacophores. Active site of targets may be addressed by each of the pharmacophores and proffers the opportunity for selectivity. In addition, it also reduced the undesirable side

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!