Relevant bibliographies by topics / Quinazoline

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Quinazoline'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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Journal articles on the topic "Quinazoline"

1

Abu-Hashem, Ameen. "Synthesis of New Furothiazolo Pyrimido Quinazolinones from Visnagenone or Khellinone and Antimicrobial Activity." Molecules 23, no. 11 (2018): 2793. http://dx.doi.org/10.3390/molecules23112793.

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Substituted-6-methyl-1-thioxo-1,2-dihydro-3H-furo[3,2-g]pyrimido[1,6-a]quinazolin-3-ones (5a,b) were synthesized from condensation of visnagenone (2a) or khellinone (2b) with 6-amino-thiouracil (3) in dimethylformamide or refluxing of (4a) or (4b) in dimethylformamide. Hence, compounds (5a,b) were used as the starting materials for preparing many new heterocyclic compounds such as; furo[3,2-g]pyrimido[1,6-a]quinazoline (6a,b), furo[3,2-g]thiazolo[2′,3′:2,3]pyrimido[1,6-a]quinazolinone (7a,b), substituted-benzylidene-furo[3,2-g]thiazolo[2′,3′:2,3]pyrimido[1,6-a]quinazoline-3,5-dione (8a–f), 3-o
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Vishwakarma, Lav Kush Kumar, and Varsha Kashaw. "Nanocatalyzed Synthetic Approach for the Quinazolinone and Quinazoline Derivatives: A Review (2015 – Present)." Journal of Drug Delivery and Therapeutics 13, no. 3 (2023): 171–83. http://dx.doi.org/10.22270/jddt.v13i3.5765.

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Due to their diverse chemical reactivities and essential range of biological action, quinazolines and their derivatives rank among the most significant heterocyclic compounds. Quinazoline and quinazolinone scaffolds pharmacological properties have sparked medicinal chemists' interest in creating original medications or drug candidates. The growth of quinazoline hybrid lead compounds and the related heterocycles is summarised in the current review of medicinal chemistry. Additionally, by shedding light on the potential significance of these hybridised pharmacophoric characteristics in the demon
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Asif, Mohammad. "Chemical Characteristics, Synthetic Methods, and Biological Potential of Quinazoline and Quinazolinone Derivatives." International Journal of Medicinal Chemistry 2014 (November 13, 2014): 1–27. http://dx.doi.org/10.1155/2014/395637.

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The heterocyclic fused rings quinazoline and quinazolinone have drawn a huge consideration owing to their expanded applications in the field of pharmaceutical chemistry. Quinazoline and quinazolinone are reported for their diversified biological activities and compounds with different substitutions bring together to knowledge of a target with understanding of the molecule types that might interact with the target receptors. Quinazolines and quinazolinones are considered as an important chemical for the synthesis of various physiological significance and pharmacological utilized molecules. Quin
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Pan, Wan-Chen, Mei-Mei Zhang, Jian-Quan Liu, and Xiang-Shan Wang. "Silver Triflate Catalyzed Synthesis of Isoquinolino[2,1-a]quinazo­lino[3,2-c]quinazoline Derivatives via Alkyne Hydroamination." Synthesis 51, no. 16 (2019): 3101–8. http://dx.doi.org/10.1055/s-0037-1611808.

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Using 2-(2-aminophenyl)quinazolin-4(3H)-one and 2-(2-phenylethynyl)benzaldehyde as the reactants, silver triflate (AgOTf) was proved to be an efficient catalyst to promote not only quinazoline cyclization, but also the intramolecular hydroamination of alkyne for the synthesis of 6-aryl-17H,18aH-isoquinolino[2,1-a]quinazolino[3,2-c]quinazolin-17-one derivatives in high yields.
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Alla, Manjula, Gal Potuganti, and Divakar Indukuri. "An Efficient One-Pot Multicomponent Synthesis of Tetracyclic Quinazolino[4,3-b]quinazolines by Sequential C–N Bond Formation and Copper-Mediated Aerobic Oxidative Cyclization." Synlett 29, no. 13 (2018): 1717–22. http://dx.doi.org/10.1055/s-0036-1591578.

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An efficient one-pot synthesis of quinazolino[4,3-b]quinazoline derivatives has been accomplished, starting from 2-(2-bromo­phenyl)quinazolin-4(3H)-one, aldehydes, and various nitrogen sources under aerobic conditions. The multicomponent protocol is mediated by copper(I) salts and involves amination of 2-(2-bromophenyl)quinazolin-4(3H)-one, followed by condensation with the aldehyde and an oxidative cyclization to give the target compounds in moderate to good yields.
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Peter Osarodion Osarumwense, Mary Olire Edema, and Cyril Odianosen Usifoh. "Synthesis and antibacterial activities of quinazolin-4(3h)-one, 2-methyl-4(3h)-quinazolinone and 2–phenyl-4(3h)-quinazolinone." International Journal of Biological and Pharmaceutical Sciences Archive 1, no. 2 (2021): 077–84. http://dx.doi.org/10.30574/ijbpsa.2021.1.2.0027.

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Background: Quinazoline and quinazolinone scaffolds represent an important class of biologically active nitrogen heterocyclic compounds. Many marketed drugs are based on these moieties. A diverse range of molecules with quinazoline/quinazolinone moieties have been reported to exhibit broad spectrum of biological activities Objective: This study is aimed at the synthesis of these quinazolinone derivatives, quinazolin-4(3H)-One, 2-Methyl-4(3H)-quinazolinone and 2–Phenyl-4(3H)-quinazolin-4(3H)–one and evaluate them for their antibacterial activities. Method: The consolidation of 2-amino-methyl-4-
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Kut, D., M. M. Kut, M. Yu Onysko, V. V. Pantyo, E. M. Danko, and G. M. Koval. "ANTIMICROBIAL ACTIVITY OF LINEAR CHALCOGEN-FUNCTIONALIZED DERIVATIVES OF THIAZOLO[2,3-b]QUINAZOLINIUM." Scientific Bulletin of the Uzhhorod University. Series «Chemistry» 52, no. 2 (2024): 59–66. https://doi.org/10.24144/2414-0260.2024.2.59-66.

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The study examines the antimicrobial activity of linear chalcogen-functionalized derivatives in the thiazoloquinazoline series against the pathogen Staphylococcus aureus and investigates the influence of low-intensity laser radiation on the sensitivity of thiazolo[2,3-b]quinazoline chlorides. The research involved synthesizing the investigated thiazolo[2,3-b]quinazoline chlorides via chalcogen-induced cyclization. For the first time, 2,3-dihydro-2-((trichloro-λ4-selanyl)methyl)-5-oxo-8-(trifluoromethyl)-5H-thiazolo[2,3-b]quinazolin-10-ium chloride was obtained, and its structure was confirmed
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Starikova, Alla Andreevna, Alexandra Aleksandrovna Tsibizova, and Marina Aleksandrovna Samotrueva. "BIOLOGICAL ACTIVITY OF NATURAL QUINAZOLINE ALKALOIDS." Chemistry of plant raw material, no. 2 (May 4, 2025): 47–73. https://doi.org/10.14258/jcprm.20250214908.

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To date, quinazoline alkaloids of natural origin, as well as synthetic derivatives based on them, whose structure contains an aromatic heterocyclic system including a pyrimidine cycle and a benzoin ring connected to it, are promising according to the criterion of the optimal profile of pharmacological activity. Currently, several hundred compounds of the quinazoline nature have been identified with a wide range of biological activities, including psychotropic (antidepressant, antipsychotic, sedative, hypnotic, anticonvulsant, etc.), antiplatelet, hypotensive, anti-inflammatory, antioxidant and
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Jianghong, Man, Qi Jianbin, Jiang Jie, and Li Sha. "Microwave Reaction Improved Heterocyclization of Quinazolinone Ring in Synthesis of Erlotinib Analogues." Journal of Pharmaceutical and Biomedical Sciences 10, no. 05 (2020): 99–105. https://doi.org/10.1234/zenodo.3876.

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Background Tinibs were a kind of important epidermal growth factor receptor (EGFR) inhibitors used as potential therapeutic agents in treating non-small cell lung cancer (NSCLC) in clinic. The drug resistance of clinical used tinibs made the development of more active tinib analogues an attractive field in research. Quinazoline ring was regarded as the key fragment in tinibs and quinazolinone was indispensible intermediate in the synthesis of quinazoline. Thus, synthesis of quinazolinone intermediates was a key step which would further limit the overall yield of final product of tinib analogue
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Widiyana, Anita Puspa. "COMPUTATION DESIGN OF QUINAZOLINE-4(3H)-ON DERIVATIVES AS CYCLOOXYGENASE-2 (COX-2) INHIBITOR." Jurnal Farmasi Sains dan Praktis 7, no. 2 (2021): 163–70. http://dx.doi.org/10.31603/pharmacy.v7i2.4827.

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 The 3-(benzylideneamino)-2-(2,4-dichlorophenyl)-quinazoline-4(3H)-ones (BDCQ) are compounds developed as anticancer drugs and quinazolines. The activity and bioavailability of BDCQ derivatives as anticancer compounds that inhibit COX-2 can be predicted by computer programs and online servers. Substituents are added at positions 2 and 3 to the quinazoline-4(3H)-on ring, such as -H, -NO2, -OCH3, -N(CH3)2, -SO2NH2, -OH, and –OCH3. QSAR as COX-2 inhibitor analysis was performed by SPSS Ver. 21 software. Lipinski’s rule of five for determining bioavailability is performe
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Dissertations / Theses on the topic "Quinazoline"

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Xu, Lu. "New quinazoline analogues as NF-κB activation inhibitors". Scholarly Commons, 2013. https://scholarlycommons.pacific.edu/uop_etds/152.

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NF-κB is a transcription factor protein complex that plays an important role in some cancers and inflammatory responses. It can enhance the proliferation rate, reduce apoptosis, as well as create more blood flow to ensure the survival of cancer. Thus blocking the NF-κB pathway has potential therapeutic benefit. We designed a series of compounds based on quinazoline scaffold pharmacophore model which may have high binding affinity with p50 subunit of NF-κB. The compound series with phenyl substitution at position 2 of quinazoline proved to be more effective at inhibiting NF-κB function both the
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El, Ghammarti Samira. "Étude des voies de synthèse de bioisostères de la néothramycine." Lille 1, 1995. http://www.theses.fr/1995LIL10182.

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La néothramycine est une entité connue pour ses propriétés antitumorales ; elle appartient à la famille des pyrrolobenzodiazépines dont le chef de file est l'anthramycine. La néothramycine se distingue des autres membres de cette famille par sa faible toxicité. D'un point de vue chimique, la synthèse de ces systèmes cycliques reste assez délicate car ils possèdent la fonction carbinolamine (ou son équivalent chimique) qui est très réactive et un carbone asymétrique dont la configuration (s) est indispensable à l'activité biologique. Nous nous sommes intéressés aux voies de synthèse permettant
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Dade, Jöel. "Synthèse d'hétérocycles azotés quinoléiques et quinazoliniques à visée antileishmanienne." Paris 11, 2004. http://www.theses.fr/2004PA114811.

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Ce travail de thèse consiste en la synthèse d'hétérocycles azotés originaux dérivé de quinoléines et de quinazolines. Ces composés sont des analogues structuraux de quinoléines naturelles de type Chimanine douées d'activité antileishmanienne. Nous avons, au cours de ce travail, préparé une centaine de quinoléines et quinazolines qui ont été évaluées contre Leishmania donovani donovani, et leishmania amazonensis. Des tests en vue d'une recherche d'activité antipaludique sont également en cours. Nous avons également étudié la réactivité des quinazolines substituées par un époxyde en position 2 v
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Zeghida, Walid. "Conception et Synthèse d'Hétérocycles Azotés Polyfonctionnalisés Biologiquement Actifs: Des Acridines aux Quinazolines." Phd thesis, Grenoble 1, 2007. http://www.theses.fr/2007GRE10254.

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Ce travail porte sur la conception de dérivés d’aminoacridine et de quinazoline. Dans une première partie, nous avons préparé des dérivés d’aminoacridine ortho-hydroxyméthylée. Pour synthétiser ces dérivés nous avons mis au point une stratégie efficace et générale mettant en jeu la préparation d’un intermédiaire-clé qui peut ensuite être fonctionnalisé. A partir de ce dernier nous avons préparé des dérivés substitués par un motif guanidine. Nous avons également préparé un dérivé iodé afin d’étudier sa distribution cellulaire par microscopie ionique (SIMS). Les propriétés biologiques (IC50 et d
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Zeghida, Walid. "Conception et Synthèse d'Hétérocycles Azotés Polyfonctionnalisés Biologiquement Actifs: Des Acridines aux Quinazolines." Phd thesis, Université Joseph Fourier (Grenoble), 2007. http://tel.archives-ouvertes.fr/tel-00221136.

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Ce travail porte sur la conception de dérivés d'aminoacridine et de quinazoline. Dans une première partie, nous avons préparé des dérivés d'aminoacridine ortho-hydroxyméthylée. Pour synthétiser ces dérivés nous avons mis au point une stratégie efficace et générale mettant en jeu la préparation d'un intermédiaire-clé qui peut ensuite être fonctionnalisé. A partir de ce dernier nous avons préparé des dérivés substitués par un motif guanidine. Nous avons également préparé un dérivé iodé afin d'étudier sa distribution cellulaire par microscopie ionique (SIMS). Les propriétés biologiques (IC50 et d
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Larraufie, Marie-Hélène. "Development of new radical cascades and multi-component reactions : application to the synthesis of nitrogen-containing heterocycles." Paris 6, 2011. http://www.theses.fr/2011PA066516.

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Le travail décrit dans ce manuscrit de thèse est consacré au développement de nouvelles méthodes radicalaires et organométalliques permettant la synthèse de différentes classes de polycycles azotés. Nous avons étudié des cascades impliquant le motif N-acylcyanamide. Des précurseurs de type alkyle ont permis la synthèse de quinazolinones naturelles. L’utilisation de précurseurs vinyliques a permis de mettre à jour un processus de migration original, qui apporte de nouveaux éléments pour la compréhension du mécanisme de substitution aromatique homolytique. Enfin des radicaux aminyles ont pu être
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Li, Jiyang [Verfasser]. "Investigation of Phthalazine, Quinazoline and Pyrimidine Derivatives as ABCG2 Inhibitors / Jiyang Li." Bonn : Universitäts- und Landesbibliothek Bonn, 2018. http://d-nb.info/1167857135/34.

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Malecki, Natacha. "Conception et synthese de derives quinoleiniques et quinazoliniques inhibiteurs potentiels des topoisomerases i et ii." Lille 2, 2001. http://www.theses.fr/2001LIL2P251.

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Chibani, Aïssa. "Électrosynthèse d'hétérocycles azotes du type quinoléine, quinazoline et triazine par réduction de nitrobenzènes o-substitues." Rennes 1, 1992. http://www.theses.fr/1992REN1A004.

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Marks, Kevin Randall. "Investigating the fluoroquinolone-topoisomerase interaction by use of novel fluoroquinolone and quinazoline analogs." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/1018.

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Fluoroquinolones are broad-spectrum antibacterial agents based on the structure of nalidixic acid. For nearly five decades it has been known that fluoroquinolones inhibit bacterial growth by blocking the enzymatic action of type II topoisomerases such as DNA gyrase and topoisomerase IV. Only recently has it been discovered that some fluoroquinolones are capable of a mechanism that results in fragmented DNA and leads to rapid bacterial cell death. This mechanism is not well understood. Presented here are studies towards understanding the structure activity relationship (SAR) of fluoroquinolones
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Books on the topic "Quinazoline"

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Brown, D. J. Quinazolines. Wiley, 1996.

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Feldmann, Burkhard. Darstellung und spektroskopische Eigenschaften neuer H-Chelate der Chinazolinreihe. Hartung-Gorre, 1986.

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Gamal Al-kaf, Ali, ed. Quinazolinone and Quinazoline Derivatives. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.85315.

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Quinoxalines. Wiley, 2004.

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Brown, Desmond J. Quinazolines, Supplement 1. Wiley & Sons, Incorporated, John, 2007.

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Brown, Desmond J. Quinazolines, Supplement 1. Wiley & Sons, Incorporated, John, 2009.

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Joshi, B. L. Some studies with quinazolines and related compounds. 1985.

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Qualmann, Christiane. Multidrug-resistente menschliche lymphoblastoide T-Zellinien als Modell zur Charakterisierung des Kreuzresistenzverhaltens neuer Zytostatika: Untersuchung von Quinazolin- und Anthrapyrazol-Derivaten. 1992.

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Book chapters on the topic "Quinazoline"

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Barker, A. J., L. R. Hughes, P. Warner, K. Burrows, and A. L. Jackman. "Thymidylate Synthase Inhibition of Modified Quinazoline Antifolates." In Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development. Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3492-1_4.

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Gros, Philippe C. "Other Stoichiometric Metalation Reactions on Pyrimidine and Quinazoline." In Topics in Heterocyclic Chemistry. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/7081_2012_93.

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Kolarovič, Andrej. "Lithiations and Grignard Reactions on Pyrimidine and Quinazoline." In Topics in Heterocyclic Chemistry. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/7081_2012_94.

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Panwar, Vivek, Kritika Mukherji, Manjunath Ghate, Deepak K. Jindal, and Deepak Kumar. "EGFR-Targeted Quinazoline Clubbed Heterocycles as Anticancer Agents." In Biomedical Translational Research. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-9232-1_21.

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Dangi, R. R., N. S. Chundawat, and K. L. Ameta. "Synthesis and Biological Evaluation of Some Quinazoline Heterocyclic Derivatives." In Green Chemistry: Synthesis of Bioactive Heterocycles. Springer India, 2014. http://dx.doi.org/10.1007/978-81-322-1850-0_13.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of nickel(II) complex with quinazoline ligand." In Magnetic Properties of Paramagnetic Compounds, Magnetic Susceptibility Data, Volume 5. Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-662-65098-1_321.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of manganese(II) complex with quinazoline ligand." In Magnetic Properties of Paramagnetic Compounds, Magnetic Susceptibility Data, Volume 5. Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-662-65098-1_56.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of cobalt(II) complex with quinazoline ligand." In Magnetic Properties of Paramagnetic Compounds, Magnetic Susceptibility Data, Volume 5. Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-662-65098-1_245.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of copper(II) complex with quinazoline ligand." In Magnetic Properties of Paramagnetic Compounds, Magnetic Susceptibility Data, Volume 5. Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-662-65098-1_411.

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da Silva, Maria Fátima das Graças Fernandes, João Batista Fernandes, Moacir Rossi Forim, Paulo Cezar Vieira, and Israel Cívico Gil de Sá. "Alkaloids Derived from Anthranilic Acid: Quinoline, Acridone, and Quinazoline." In Natural Products. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-22144-6_25.

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Conference papers on the topic "Quinazoline"

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Guerreiro Souzedo, Gabriela, LJUBICA TASIC, and Caio Henrique Nasi De Barros. "Synthesis of Quinazoline Derivatives for Adenosine Kinase Inhibition." In XXV Congresso de Iniciação Cientifica da Unicamp. Galoa, 2017. http://dx.doi.org/10.19146/pibic-2017-78452.

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Fadil MOUSA, Enaam, and Ibtissam Khalifa JASSIM. "SYNTHESIS ,CHARACTERIZATION AND BIOLOGICAL ACTIVITY STUDY OF SOME HETEROCYCLIC COMPOUNDS." In IV.International Scientific Congress of Pure,Appliedand Technological Sciences. Rimar Academy, 2022. http://dx.doi.org/10.47832/minarcongress4-18.

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Heterocycles are an important class of organic compounds because of their applications in medicines and industrial fields. Therefore our study included preparation of these compound such as oxazepine and quinazoline rings, which were prepared through two steps: The first step included the reaction of the Schiff bases derived from sulfamethaxazole (1-4) with each of phthalic anhydride and 3- nitrophthalic anhydride for the preparation of oxazepines (5-12) .While the second step included the preparation of quinazoline compounds (13-16) from the reaction of Schiff bases (1-4) with anthranilic aci
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Militaru, Andra, Adriana Smarandache, Abdallah Mahamoud, et al. "Stability Characterization of Quinazoline Derivative BG1188 by Optical Methods." In ADVANCES IN LASEROLOGY - SELECTED PAPERS OF LASER FLORENCE 2010: The 50th Birthday of Laser Medicine World. AIP, 2011. http://dx.doi.org/10.1063/1.3626907.

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Kumar, Balbir, Naresh Sharma, Asif Ali, and Vivek K. Gupta. "Crystallographic structure analysis of 4-phenoxy-2-(4-(trifluoromethyl)phenyl) quinazoline." In NATIONAL CONFERENCE ON RECENT ADVANCES IN EXPERIMENTAL AND THEORETICAL PHYSICS (RAETP-2018). Author(s), 2018. http://dx.doi.org/10.1063/1.5051271.

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Fatykhov, Ramil F., Igor A. Khalymbadzha, Vladimir L. Rusinov, and Oleg N. Chupakhin. "Modification of 1-hydroxy-3-methoxy-10-methylacridone by quinazoline and quinoxalone." In PROCEEDINGS OF INTERNATIONAL CONFERENCE ON RECENT TRENDS IN MECHANICAL AND MATERIALS ENGINEERING: ICRTMME 2019. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0028211.

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Hussein, AL-Shaimaa Anas, and Fawzi Hameed Jumaa. "Preparation and evaluation of quinazoline derivatives as antimicrobial agents and liquid crystals." In 4TH INTERNATIONAL CONFERENCE ON INNOVATION IN IOT, ROBOTICS AND AUTOMATION (IIRA 4.0). AIP Publishing, 2025. https://doi.org/10.1063/5.0254204.

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Tojiboev, Akmaljon, Sherzod Zhurakulov, Ulli Englert, et al. "Hirshfeld surface analysis and energy framework for crystals of quinazoline methylidene bridged compounds." In The 2nd International Online Conference on Crystals. MDPI, 2020. http://dx.doi.org/10.3390/iocc_2020-07235.

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OuYang, Yiqiang, Chen Chen, Ping Wang, Chao Sun, WuFu Zhu, and Shan Xu. "Synthesis of N-4-(4-chloro-3-trifluoromethyl-phenyl)-7-methoxy-quinazoline-4,6-diamine." In 2015 2nd International Conference on Machinery, Materials Engineering, Chemical Engineering and Biotechnology. Atlantis Press, 2016. http://dx.doi.org/10.2991/mmeceb-15.2016.158.

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Christopher, Williams, Larroque Anne‐Laure, Huang Ying, et al. "Abstract A142: Molecular modeling approach to the rational design of promiscuous quinazoline‐based EGFR inhibitors." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 15-19, 2009; Boston, MA. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/1535-7163.targ-09-a142.

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Yen, Shih Chieh, Shao-Zheng Peng, Hung-Jyun Huang, et al. "Abstract 2809: Novel 2,5,8-trihydro-6,7-disubstituted-4-(3'-alkylsulfonamidoanilino) quinazoline derivatives as RAF inhibitor." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-2809.

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