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Dissertations / Theses on the topic 'Quinazoline derivatives'

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Published: 3 June 2025

Last updated: 1 August 2025

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1

Li, Jiyang [Verfasser]. "Investigation of Phthalazine, Quinazoline and Pyrimidine Derivatives as ABCG2 Inhibitors / Jiyang Li." Bonn : Universitäts- und Landesbibliothek Bonn, 2018. http://d-nb.info/1167857135/34.

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2

Krapf, Michael [Verfasser]. "Investigation of Quinazoline Derivatives as Inhibitors of Breast Cancer Resistance Protein (BCRP/ABCG2) / Michael Krapf." Bonn : Universitäts- und Landesbibliothek Bonn, 2018. http://d-nb.info/1160594155/34.

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3

Cardoso, Leandro 1979. "Utilização farmacológica de um composto inédito derivado de quinazolina como inibidor potencial da quinase de adesão focal (FAK) no processo de hipertrofia cardíaca em camundongo = Pharmacological use of a novel compound quinazoline derivative as potential inhibitor of the focal adhesion kinase in the process of cardiac hypertrophy in mice." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310205.

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Orientador: Kleber Gomes Franchini<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-20T23:08:02Z (GMT). No. of bitstreams: 1 Cardoso_Leandro_M.pdf: 3831901 bytes, checksum: 40e5df211d7e6fd923f654bd8d3a1ec1 (MD5) Previous issue date: 2012<br>Resumo: Nas doenças do coração ocorre hipertrofia e remodelamento do ventrículo esquerdo com impacto negativo na evolução clínica. Esses fatores influenciam independentemente o risco cardiovascular por elevarem a predisposição a infartos do miocárdio, ao desenvolvimento de

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4

Li, Hong-Bin, and 李鴻斌. "Study of 4-(Substitutedphenylamino)Quinazoline Derivatives." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/12061863258573308290.

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碩士<br>文化大學<br>應用化學系<br>85<br>The objective of this thesis is to investigate the synthesis of 4-(substitutedphenylamino)quinazoline derivatives. Because the C4-C8 sites of the compound with different substituents are able to be used as tyrosine kinase inhibitors.In the study,it consist of three synthetic processes.Firstly,the starting material, monochloroanthranilic acid and dichloroanthranilic acid reacted with formamide in high temperature and refluxed to give mono- and di-chloro substitut

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Huang, Ya-Ping, and 黃雅蘋. "Synthesis and Antiproliferative Evaluation of Substituted Quinazoline Derivatives." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/29298330647027420014.

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碩士<br>高雄醫學大學<br>醫藥暨應用化學研究所<br>100<br>Quinazoline derivatives have been found to possess a wide variety of biological activities. The aims of this thesis are to synthesize and evaluate a series of 4-substituted and 2-substituted-vinyl quinazoline derivatives. These 4-substituted and 2-substituted-vinyl quinazoline derivatives with various substituents at the C-4 position of quinazoline skeleton and at the vinyl moiety have been synthesized and evaluated for their antiproliferatve activities. Results indicated that most of these newly synthesized compounds exhibited potent activities against the

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Chuang, Ming-Hsueh, and 莊明學. "Design and Synthesis of Quinazoline Derivatives as Potential Antitumor Agents." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/73920432922782901061.

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博士<br>靜宜大學<br>應用化學系<br>104<br>In this thesis, a series of 2-, 4-, 6, and 7-substituted quinazoline derivatives were designed and synthesized as well as their cytotoxicities againststomach cancer cell line AGS, lung cancer cell lines A549, hepatocellular liver carcinoma cell line HepG2, colon cancer cell line HT-29 andprostate cancer cell line PC-3 were evaluated. Target compounds 4a,b and 6a,b are 4-cyclohexylamino/cyclohexanemethylamino and 2-(substituted anilino) substituted quinazoline. Among them, 4b and 6a possess moderate inhibitory activity against HT-29. Introducing methoxy groups onto

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7

Fu, Chen-Hsiang, and 傅振翔. "Quinazoline derivatives inhibition the effectiveness of the Japanese encephalitis virus." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/82714509177713491399.

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碩士<br>亞洲大學<br>生物科技學系<br>103<br>Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus with a positive-sense single-stranded RNA genome, causing encephalitis with permanent neurological sequelae in Asia. Currently, there is no effective cure except vaccination. Quinazolinone derivatives(QD) have anti-malarial, anti-inflammatory, anti-bacterial and anti-tumor activities. The aim of this study is to discover antiviral activity of novel QDs against JEV in vitro using the assays ofcytopathic effectinhibition, apoptosis with propidiumiodide(PI) stain, plaque reduction, reporter assay, viru

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8

Pao, Kuan-Chuan, and 鮑冠全. "Design and Synthesis of Novel Quinazoline Derivatives as CIP2A-Ablating Agents." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/69444822770617253977.

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碩士<br>國立陽明大學<br>生物藥學研究所<br>100<br>Cancerous inhibitor of PP2A (CIP2A) is a novel oncoprotein which could stabilize the c-Myc by inhibiting PP2A (protein phosphatase 2 A) activity toward c-Myc and promoting anchorage-independent cell growth and in vivo tumor formation. Particularly, overexpression of CIP2A on several solid- and non-solid tumors has been recorded on document, including human neck and head carcinomas, colon, breast, cervical, prostate cancer, and acute leukemia. Recent studies have shown that small molecules, such as Velcade and Tarceva, exhibited the ability to downregulate the

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9

盧冠宇. "Synthesis and pharmacological evaluation of fused tricyclic thieno [2,3-d] pryimidine and quinazoline derivatives." Thesis, 1991. http://ndltd.ncl.edu.tw/handle/53126416670356751342.

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10

chou, Su-Lun, and 周書論. "Synthesis and Evaluation Anti-proliferation Ability of Quinazoline bearing Oxime, Methyloxime and Amide Derivatives." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/43051299260201664769.

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碩士<br>大仁科技大學<br>製藥科技研究所<br>102<br>The quinazoline (QA) is a heterocyclic compound with benzene fused to pyrimidine and is a well-leading structure for new drug development because it displays a wide spectrum of pharmacological activities such as neuron protective, anti-bacterial and anti-cancer properties. In this study, we have synthesized a series of novel QA derivatives and evaluated their anti-proliferative mechanisms. Firstly, QA series were subjected to MTT assay to examine the growth-inhibitory abilities against three human cancer cell lines, including nasopharyngeal cancer (NPC-TW01),

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11

Chiou, Maw-Shyang, and 邱茂祥. "Design and synthesis of oxime, methyloxime, amide containing quinazoline derivatives and evaluation anti-proliferative activity." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/33514136455255431308.

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碩士<br>大仁科技大學<br>製藥科技研究所<br>103<br>The Quinazoline is a nitrogen-containing heterocyclic skeleton of benzene and pyrimidine being formed, many quinazoline compounds islated from porducts having broad pharmacological activity including neuronal protection, anti-bacterial and anti-tumor, and therefore subject to a considerable degree in drug development emphasis. In this study, we extend the results before continuing the synthesis of a series of oxime-containing, quinazolinone derivative of methyl oxime and amide and assess its antiproliferative activity in. The assessments were selected to seven

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12

Chen, Mei-Yu, and 陳美玉. "Design and Synthesis of Quinazoline Derivatives as Potential Non-Peptide Corticotropin-Releasing Hormone Receptor (CRH1) Antagonists." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/04213898628785511139.

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碩士<br>國立臺灣大學<br>藥學研究所<br>90<br>Abstract This thesis is aimed to design and synthesize substituted arylquinazoline derivatives as potential non-peptide corticotropin-releasing hormone 1 (CRH1) receptor antagonists. According to the structure-activity relationship of a series of known CRH1 antagonists and the lead compound CP154526-1 (12), quinazoline core was intended to replace the pyrrolopyrimidine ring leading to the target compounds 8-aryl-4-(N-cyclopropylmethyl-N-propylamino)- 2-methylquinazol-ines (36-38, 40). 2-Bromoaniline (20) was the starting material to prepare 2-bromoison

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13

Dilebo, Kabelo Bramley. "Synthesis and biological activity of schiff based and ruthenium P-Cymene complexes containing ethynylpyridine bridged to quinazoline derivatives." Thesis, 2019. http://hdl.handle.net/10386/3179.

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Thesis(M.Sc. (Chemistry)) -- University of Limpopo, 2019<br>Imidazolyl-ethanamine Schiff base ligands of the N^N type were prepared by condensation reaction of histamine dihydrochloride with para-substituted aldehyde derivatives to yield: (E)-N-benzylidene-2-(1H-imidazol-4-yl)ethanamine 119a, 4-((E)(2-(1H-imidazol-4-yl)ethylimino)methyl)phenol 119b, E)-N-(4-fluorobenzylidene)-2(1H-imidazol-4-yl)ethanamine 119c and (E)-N-(4-nitrobenzylidene)-2-(1H-imidazol-4yl)ethanamine 119d, which were characterised by 1H and 13C-NMR, FTIR specroscopy and HRMS. 2D-NMR experiments (1H-1H COSY and 2D-HMBC) for

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14

Wu, Wei-chie, and 吳偉傑. "Intramolecular Imidate-Amide Rearrangement of 2-Substituted 4-(-Chloroalkoxy)quinazoline Derivatives. 1,3 -O → N Shift of Chloroalkyl Groups via Cyclic 1,3-Azaoxonium Intermediates." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/3a2p3s.

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碩士<br>靜宜大學<br>應用化學研究所<br>97<br>The alkylation of 2-substituted 4-(-chloroalkoxy)quinazoline derivatives gave the N- and O-alkylation products. However the O-alkylation products were transferred to the N-alkylation products through 1,3 -O→N shift in less a day. The mechanism is different from Chapman rearrangement because the reactants have leaving groups. The intermediate of the 1,3-O→N shift is hard to be trapped, so computational chemistry was used to explore the mechanism of the 1,3 -O→N shift. The optimized structures of 2-substituted 4-(-chloroalkoxy) quinazoline, 3-(-chloroalkyl)quina

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15

LIN, CHUN-HUNG, and 林俊宏. "Study of Quinazolinone Derivatives on Enhancement of Anticancer Drugs Activity." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/30968119740447194201.

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碩士<br>國立臺灣大學<br>藥學系研究所<br>86<br>ABSTRACT We have evaluated the effect of the quinazolinone derivatives on P-glycoprotein-mediated MDR in breast cancer by performing an in vitro cytotoxicity assay and flow cytometry. The cell lines employed for this study were human breast cancer cells selected for resistance to adriamycin, MCF7/adr, and its counterpart, wildtype MCF7. Compared with the sensitivity of the wildtype and adr-resistant cells, the MCF7/adr subline showed more th

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16

Peng, I.-Hsuen, and 彭益洵. "Effects of DC-015, a newly synthesized quinazoline derivative, on hypertension and platelet aggregation." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/27809958547111250424.

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碩士<br>國防醫學院<br>藥理學研究所<br>82<br>The purposes of these studies were to investigate the antihypertensive and antiplatelet aggregation effects of DC-015, and compare with prazosin. In anaesthetized spontaneously hypertensive rats (SHR), intravenous administration of DC-015 and prazosin (0.01, 0.05, 0.1 mg/kg) induced a dose-related reduction of mean blood pressure (MBP) which reach a maximal effect at 5 min after injection and persisted for more than 2 hours. Oral administration of DC-015

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17

Chen, Hui-ting, and 陳惠亭. "Design and Synthesis of Indolo[2,1-b]quinazolin-6,12-dione Derivatives as Potential Antitumor Agents." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/08556359314799771207.

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博士<br>國立臺灣大學<br>藥學研究所<br>88<br>This thesis is aimed to design and synthesize tryptanthrin and its analogs as potential anticancer agents. Tryptanthrin (1), indolo[2,1-b]quinazolin-6,12-dione, is a coplanar four-fused ring compound which contains N-phenylquinazoline skeleton similar to 2-phenylnaphthalene. It was illustrated that compounds containing coplanar 2-phenylnaphthalene skeletons exhibit different biological activities such as, ellipticine, camptothecin, while the bioactivities would be decreased or lost in unplanar structures. For example, batracylin, containing 2-phenyl-quinolone ske

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18

Lo, Chi-Chun, and 羅吉鈞. "Synthesis and pharmacological evaluation of 4(3H)quinazolinone derivatives as potencial angiotensin II antagonists." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/58461088283823970919.

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19

Ho, Pei-Heng, and 何沛恒. "Design and Synthesis of Quinazolines Derivatives from Amino Acid Esters ; Copper-Catalysed Aerobic Oxidative Carbocyclization- Ketonization , Synthesis of Imidazo[1,2-a]benzimidazole Derivatives." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/g4jy2w.

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20

SU-Fun, Lee, and 李樹芬. "Mechanisms of hypotensive effects of DL-017, a synthesized quinazoline derivative, in spontaneously hypertensive rats and normotensive rats." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/42633921355248358607.

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碩士<br>國防醫學院<br>生理學研究所<br>86<br>Mechanisms of hypotensive effects of 3-（（4-(2-methoxy-phenyl)piperazin-l-ly）methylthio）-2, 3-dihydroimidazo （1, 2-c）quinazoline (DL-017), a synthesized quinazoline derivative, were studied in anaesthetized Sprague-Dawley (SD) rats and spontaneously hypertensive rats (SHR).Intravenous administration of DL-017 or prazosin resulted in falls in systemic arterial blood pressure (SAP) and, except initial transient increase in some preparations, heart rate (HR) in both SD and SHR.At a dose of 0.1 mg/kg, DL-017 exerted a maximal hypotensive effect. Phenylephrine (PHE) (

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21

Hour, Mann-Jen, and 侯曼貞. "Synthesis, Cytotoxicity and Antiplatelet Activity of 6,7,2',3',4',5'-Substituted 2-phenyl-4-quinazolinone Derivatives." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/66215076548891573814.

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博士<br>中國醫藥學院<br>藥物化學研究所<br>88<br>As part of our continuing search for potential anticancer candidates of 2-phenyl-4-quinazolinones and 2-phenyl-4-quinolones, two series of 6,7,2',3',4',5'-substituted 2-phenyl-4-quinazolinones and 6,2',3',4',5'-substituted 2,3-dihydro-2-phenyl-4-quinazolinones have been synthesized and evaluated for cytotoxicity and inhibition of tubulin polymerization. Through these biological screening, a preliminary structure-activity relationship has been established. On the whole, a good correlation was found between the two activities. Among them, 6-N,N-dimethylamino and

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22

CHIA, YI-TING, and 賈貽婷. "The Anti-tumor Effect of Quinazolinone Derivative Holu-12 on Oral Squamous Cell Carcinoma Cells." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/99ecg4.

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碩士<br>慈濟大學<br>藥理暨毒理學碩士班/博士班<br>106<br>Oral squamous cell carcinoma (OSCC) is one of the common malignant diseases in the world. Through advances in multimodality therapies for the treatment of OSCC; however, the overall 5-year survival rate for OSCC patients remains at 50% without significant improvement over the past three decades. Therefore, it is necessary to develop novel potential therapeutic agents against human OSCC. Quinazolinone is a heterocyclic chemical compound having a unique place in the field of medicinal chemistry. Many quinazolinone derivatives possess a wide range of bioactiv

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23

Liu, Chih-Fa, та 劉誌發. "design and synthesis of quinazolinone and 1,2-benzothiazine 1,1-dioxide derivatives as potential selective α1A-adrenoceptor antagonists". Thesis, 2000. http://ndltd.ncl.edu.tw/handle/59531007520783388600.

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碩士<br>國立臺灣大學<br>藥學研究所<br>88<br>This study is aimed to synthesize two series of compounds, namely, substituted arylpiperazinyl benzothiazinone 1,1-dioxide (A) and substituted arylpiperazinyl quinazolinone (B) derivatives for evaluation of α1A adrenoceptor selectivity and are considered to be potential for treatment of benign prostatic hyperplasia (BPH). The synthesis of compounds in A series started from esterification of 3,4-dimethoxyphenyl acetic acid (25) in methanol with a catalytic amount of concentrated sulfuric acid to give 3,4-dimethoxy-1-(carbomethoxymethyl)benzene (26). T

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24

Salahi, Rashad al [Verfasser]. "Synthesis of novel 2-alkoxy(aralkoxy)-4H-[1,2,4]triazolo[1,5-a]quinazolin-5-ones and derivatives / by Rashad Al-salahi." 2009. http://d-nb.info/993198538/34.

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25

Lu, Chi-Cheng, and 呂啟誠. "Investigations for targeting signaling pathways in the apoptosis induction and anti-metastasis of the novel quinazolinone derivatives in leukemia and oral cancer cells in vitro and anti-tumor activity in vivo." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/69439994355722115199.

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博士<br>國立中興大學<br>生命科學系所<br>100<br>The previous studies have demonstrated that 2-phenyl 6-pyrrolidinyl-4-quinazolinone derivatives exhibited antitumor actions and biological responses. Among them, both of the most potent newly synthesized compounds, 6-pyrrolidinyl-2-(2-hydroxyphenyl)-4-quinazolinone (MJ-29) and 6-pyrrolidinyl- 2-(3-Methoxyphenyl)-4-quinazolinone (HMJ-38) for their mechanisms underlying anticancer activities remain unclear and have not been well clarified. In this dissertation, we attempt to investigate anti-leukemia and anti-oral cancer effects in vitro and in vivo. In the chapt

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