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Relevant bibliographies by topics / Quinazoline synthesis

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Dissertations / Theses

Academic literature on the topic 'Quinazoline synthesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 5 February 2022

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Dissertations / Theses on the topic "Quinazoline synthesis"

1

Larraufie, Marie-Hélène. "Development of new radical cascades and multi-component reactions : application to the synthesis of nitrogen-containing heterocycles." Paris 6, 2011. http://www.theses.fr/2011PA066516.

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Le travail décrit dans ce manuscrit de thèse est consacré au développement de nouvelles méthodes radicalaires et organométalliques permettant la synthèse de différentes classes de polycycles azotés. Nous avons étudié des cascades impliquant le motif N-acylcyanamide. Des précurseurs de type alkyle ont permis la synthèse de quinazolinones naturelles. L’utilisation de précurseurs vinyliques a permis de mettre à jour un processus de migration original, qui apporte de nouveaux éléments pour la compréhension du mécanisme de substitution aromatique homolytique. Enfin des radicaux aminyles ont pu être

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2

Ozcan, Sevil. "Development Of New Synthetic Methodologies For The Synthesis Of Unusual Isocoumarin And Indole Derivatives:the Chemistry Of Homophthalic Acid." Phd thesis, METU, 2007. http://etd.lib.metu.edu.tr/upload/3/12608197/index.pdf.

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Many heterocyclic compounds containing nitrogen, oxygen and sulfur show wide range of physiological activities and their synthesis has always been attracted the interest of chemists. The aim of this research is to develop new synthetic methodologies leading to the synthesis of new derivatives of isocoumarines, indoles, isoquinolines, benzodiazepinones and quinazolines, which have been found to show important biological activities. Starting from homophthalic acid and bishomophthalic acid the corresponding acyl azides were proposed to be synthesized, which then would be used for the synthesis of

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3

Raux, Elizabeth A. "Synthesis of Selective 5-HT6 and 5-HT7 Receptor Antagonists." Digital Archive @ GSU, 2010. http://digitalarchive.gsu.edu/chemistry_theses/32.

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The development of novel selective 5-HT6 and 5-HT7 receptor antagonists is an ever-growing area of interest among medicinal chemists. The potential of developing a therapeutic agent useful as an antipsychotic or antidepressant, as well as the possibility to develop a drug for Alzheimer’s disease and obesity has led to an increase in synthesis of possible lead compounds. The synthesis of unfused biheteroaryl derivatives is described within. The derivatives have been evaluated for binding affinity at 5-HT2A, 5-HT6 and 5-HT7 receptors. The most potent 5-HT6 receptor antagonists include a benzene

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4

Belfrage, Anna Karin. "Design and Synthesis of Hepatitis C Virus NS3 Protease Inhibitors : Targeting Different Genotypes and Drug-Resistant Variants." Doctoral thesis, Uppsala universitet, Avdelningen för organisk farmaceutisk kemi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-243317.

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Since the first approved hepatitis C virus (HCV) NS3 protease inhibitors in 2011, numerous direct acting antivirals (DAAs) have reached late stages of clinical trials. Today, several combination therapies, based on different DAAs, with or without the need of pegylated interferon-α injection, are available for chronic HCV infections. The chemical foundation of the approved and late-stage HCV NS3 protease inhibitors is markedly similar. This could partly explain the cross-resistance that have emerged under the pressure of NS3 protease inhibitors. The first-generation NS3 protease inhibitors were

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5

Doan, Thu Hong. "Synthesis, self-assembly and photophysical evaluation of fluorophores derived from acenes, heteroacenes and quinazolines." Thesis, Normandie, 2018. http://www.theses.fr/2018NORMC205.

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Les semiconducteurs organiques (OSC) tels que les composés organiques photovoltaïques (OPVs), les diodes électroluminescentes organiques (OLEDs) ou encore les transistors organiques à effet de champ (OFETs) constituent un domaine de recherche très attractif en raison de leur potentiel en tant que couches actives dans les dispositifs optoélectroniques. Les composés aromatiques polycycliques ainsi que les hétéroaromatiques sont considérés comme des matériaux prometteurs pour les OSC en raison de leurs conductivités électriques potentielles, de leurs propriétés optiques ainsi que de leurs assembl

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6

Hamed, Mostafa Mohamed Mostafa [Verfasser], та Rolf W. [Akademischer Betreuer] Hartmann. "Design and synthesis of novel quinazoline-based EGFR kinase inhibitors and dual EGFR/NF-κB inhibitors as potential anti-cancer drugs with enhanced efficacy / Mostafa Mohamed Mostafa Hamed. Betreuer: Rolf W. Hartmann". Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2013. http://d-nb.info/1078017077/34.

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7

Stein, Tobias. "Radical synthesis of quinazolinone natural products." Thesis, Loughborough University, 2007. https://dspace.lboro.ac.uk/2134/34389.

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Investigations into radical and palladium(0) cyclisations onto the C-2 position of the 3H-quinazolin-4-one moiety have been made. This has led to the syntheses of a number of biologically active quinazolinone natural products using alkyl, heteroaryl and acyl radical cyclisations. The reactions proceeded via a homolytic aromatic substitution mechanism. As such, fully rearomatised products were recovered. A C-2 radical 3H-quinazolin-4-one building block was also prepared. This turned out to have only limited synthetic applications. Radical cyclisations onto aryl groups were carried out using thi

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8

Norrie, R. "The synthesis and reactions of sulphur analogues of deoxyvasicinone." Thesis, University of Abertay Dundee, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233850.

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9

Dai, Xuedong 1970. "Synthesis and applications of atropisomeric quinazolinone phosphine ligands." Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/47887.

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Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1998.<br>Includes bibliographical references.<br>Several novel atropisomeric phosphine ligands have been synthesized and evaluated. The syntheses of 2-methyl-3-[2'-(diphenylphosphino)phenyl]-4(3H)- quinazolinone (la) and its methyl-substituted analogs lb and ic were achieved in good yield by coupling N-acetylanthranilic acid with the corresponding phosphinoanilines 4a-c. A practical resolution of ligands la-c was accomplished using the benzenesulfonylhydrazone derivative (10) of (1S)-(+)-camphorsulfonic acid as a novel

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10

Pertusati, Fabrizio. "Synthesis of atropisomeric 2,2'-disubstituted-3,3'-quinazolin-4,4'-diones and their application in asymmetric synthesis." Thesis, Cardiff University, 2007. http://orca.cf.ac.uk/54687/.

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This thesis reports all the efforts made in the synthesis of 2,2'-disubstituted-3,3'-quinazolin-4,4'-ones (BiQ), a new class of atropisomeric molecules derived from the 4-quinazolinone scaffold, and their potential application as chiral auxiliaries in asymmetric synthesis. Chapter 1 provides first an overview of axial chirality and atropisomerism and then it reports a review of asymmetric reactions such as Diels-Alder, 1,3-dipolar cycloaddition, epoxydation and cyclopropanation, which have been used in literature as a model for the development of new chiral auxiliaries and chiral ligands. Chap

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