Log in

Relevant bibliographies by topics / Quinazolinona / Journal articles

To see the other types of publications on this topic, follow the link: Quinazolinona.

Journal articles on the topic 'Quinazolinona'

Author: Grafiati

Published: 9 September 2021

Last updated: 8 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Quinazolinona.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Kong, Xiang-Fei, Xiu-Yun Guo, Zi-Yu Gu, et al. "Silver(i)-catalyzed selective hydroalkoxylation of C2-alkynyl quinazolinones to synthesize quinazolinone-fused eight-membered N,O-heterocycles." Organic Chemistry Frontiers 7, no. 15 (2020): 2055–62. http://dx.doi.org/10.1039/d0qo00437e.

Full text

Abstract:

A silver-catalyzed selective 8-endo-dig cyclization of C2-alkynyl quinazolinones was developed to prepare a series of novel quinazolinone-fused eight-membered N,O-heterocycles in good-to-excellent yields under mild reaction conditions.

APA, Harvard, Vancouver, ISO, and other styles

2

Komar, Mario, Maja Molnar, and Anastazija Konjarević. "Screening of Natural Deep Eutectic Solvents for Green Synthesis of 2-methyl-3-substituted Quinazolinones and Microwave-Assisted Synthesis of 3-aryl Quinazolinones in Ethanol." Croatica chemica acta 92, no. 4 (2020): 511–17. http://dx.doi.org/10.5562/cca3597.

Full text

Abstract:

In this study, two fast and efficient protocols for green synthesis of 3-substituted quinazolinones were perfomed. A synthesis of 2-methyl-3-substituted quinazolinones was performed in natural deep eutectic solvents, while 3-aryl quinazolinones were obtained by using microwave assisted synthesis. Benzoxazinone, which was used as an intermediate in the synthesis of 2-methyl-3-substituted quinazolinones, was prepared conventionally from anthranilic acid and acetic anhydride. In order to find the most appropriate synthetic path, twenty natural deep eutectic solvents were applied as a solvent in t

APA, Harvard, Vancouver, ISO, and other styles

3

Asif, Mohammad. "Chemical Characteristics, Synthetic Methods, and Biological Potential of Quinazoline and Quinazolinone Derivatives." International Journal of Medicinal Chemistry 2014 (November 13, 2014): 1–27. http://dx.doi.org/10.1155/2014/395637.

Full text

Abstract:

The heterocyclic fused rings quinazoline and quinazolinone have drawn a huge consideration owing to their expanded applications in the field of pharmaceutical chemistry. Quinazoline and quinazolinone are reported for their diversified biological activities and compounds with different substitutions bring together to knowledge of a target with understanding of the molecule types that might interact with the target receptors. Quinazolines and quinazolinones are considered as an important chemical for the synthesis of various physiological significance and pharmacological utilized molecules. Quin

APA, Harvard, Vancouver, ISO, and other styles

4

Mishra, AD. "A New Route for the Synthesis of Quinazolinones." Nepal Journal of Science and Technology 12 (July 22, 2012): 133–38. http://dx.doi.org/10.3126/njst.v12i0.6491.

Full text

Abstract:

Quinazolinone derivatives are highly bioactive heterocyclic compounds with wider range of microbial activities such as anti-malarial, anti-cancer, anti-inflammatory, anti-hypertensive, anti-convulsant, anti-HIV, etc. Solid supported microwave synthesis of some 3-substituted-4-(2H)-quinazolinones has been carried out by the reaction of anthranilic acid, formaldehyde and primary aromatic amines. The usage of hazardous reagents and organic solvents has been avoided. The reactions were conducted in presence of acidic alumina where formaldehyde entered into cycloaddition to yield the quinazolinone

APA, Harvard, Vancouver, ISO, and other styles

5

Mahmoud, Mahmoud Refaee, Manal Mohamed El-Shahawi, and Fatma Saber Mohamed Abu El-Azm. "Synthesis of novel quinazolinone and fused quinazolinones." European Journal of Chemistry 2, no. 3 (2011): 404–9. http://dx.doi.org/10.5155/eurjchem.2.3.404-409.267.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Koketsu, Mamoru, Amol Sonawane, Yunnus Shaikh, and Dinesh Garud. "Synthesis of Isoquinoline-Fused Quinazolinones through Ag(I)-Catalyzed Cascade Annulation of 2-Aminobenzamides and 2-Alkynylbenzaldehydes." Synthesis 51, no. 02 (2018): 500–507. http://dx.doi.org/10.1055/s-0037-1610910.

Full text

Abstract:

A new route for the expedient synthesis of a specific regioisomer of isoquinoline-fused quinazolinones is reported. Silver(I)-catalyzed cascade cyclization of 2-aminobenzamides and 2-alkynylbenzaldehydes followed by in situ oxidation gives 12-butyl- or 12-aryl-6H-isoquinolino[2,1-a]quinazolin-6-ones in 69–91% yields. The structure of the isoquinoline-fused quinazolinone was confirmed by X-ray crystallography analysis.

APA, Harvard, Vancouver, ISO, and other styles

7

D, Priya, Srimathi R, and Anjana Gv. "SYNTHESIS AND EVALUATION OF SOME MANNICH BASES OF QUINAZOLINONE NUCLEUS." Asian Journal of Pharmaceutical and Clinical Research 11, no. 2 (2018): 407. http://dx.doi.org/10.22159/ajpcr.2018.v11i2.22644.

Full text

Abstract:

Objective: In the present work, a series of five Mannich bases of quinazolinone nucleus synthesized by treating quinazolinones with various aromatic amines.Methods: A series of Mannich bases of quinazolinone synthesized by refluxing quinazolinone with anthranilic acid, amine, and formaldehyde in ethanol. The chemical structures of synthesized compounds were confirmed by thin-layer chromatography using the suitable solvent system and characterized by melting point and IR. The compounds screened for their antibacterial activity and antioxidant activity.Results: Antioxidant activity of the synthe

APA, Harvard, Vancouver, ISO, and other styles

8

Smith, Keith, Gamal A. El-Hiti, Mohamed F. Abdel-Megeed, and Mohamed A. Abdo. "Convenient Synthesis of More Complex 2-Substituted 4(3H)-Quinazolinones via Lithiation of 2-Alkyl-4(3H)-quinazolinones." Collection of Czechoslovak Chemical Communications 64, no. 3 (1999): 515–26. http://dx.doi.org/10.1135/cccc19990515.

Full text

Abstract:

2-Methylquinazolin-4(3H)-one has been doubly lithiated, at nitrogen and in the 2-methyl group, with n-butylithium. The lithium reagent thus obtained reacts with a variety of electrophiles (iodomethane, D2O, phenyl isocyanate, benzaldehyde, benzophenone, cyclopentanone, 2-butanone, carvone) to give the corresponding 2-substituted derivatives in very good yields. Reaction of the dilithio reagent with acetonitrile gives an α,β-unsaturated imine by tautomerization of the initial addition product. Double lithiation of 2-ethyl- and 2-propyl-4(3H)-quinazolinones can be achieved using lithium diisopro

APA, Harvard, Vancouver, ISO, and other styles

9

EL-BADRY, Y. A., and S. N. ABDOU. "CONSTRUCTION OF SOME NOVEL BIOCIDAL N-ALKYLATED QUINAZOLINE-4(3H)- ONE DERIVATIVES USING MICROWAVE ACTIVATION." Periódico Tchê Química 15, no. 30 (2018): 463–72. http://dx.doi.org/10.52571/ptq.v15.n30.2018.466_periodico30_pgs_463_472.pdf.

Full text

Abstract:

Microwave-assisted construction of 2-propylquinazolinone1 has been achieved, followed by its subsequent utilities in constructing an attractive series of 2,3-disubstituted functional quinazolinones 2-10. The use of microwave irradiation in performing N-alkylation for the titled quinazolinone 1 was applied as a simple, efficient and eco-friendly green technique. Furthermore, the in vitro antimicrobial screening of the obtained compounds 3-10 has been investigated against four bacterial strains and two fungal strains. The structure of the synthesized molecules was affirmed using analytical and s

APA, Harvard, Vancouver, ISO, and other styles

10

B. Deshmukh, M., and Savita Dhongade (Desai). "Synthesis and QSAR Study of (4-Oxo-3-aryl-3,4-dihydro-quinazolin-2-ylsulfanyl)-propionic Acid arylidene/aryl-ethylidene-hydrazides via Microwave Assisted Solvent Free Reations." E-Journal of Chemistry 1, no. 2 (2004): 115–26. http://dx.doi.org/10.1155/2004/142148.

Full text

Abstract:

In the present work,s-alkylated derivatives of thio-quinazolinone were obtained using Methyl 2-chloro propionate via a solvent-free microwave-assisted method. The alkylated thio quinazolinones were further sequentially condensed with hydrazine hydrate and different aromatic aldehydes to get the hydrazides, which were studied for QSAR. The synthesized compounds were subjected to a prediction of biological activities. A software application (PASS) was used for this purpose. . The relationship between structure and different biological activities was studied and the different derivatives were rec

APA, Harvard, Vancouver, ISO, and other styles

11

Deshmukh, M. B., and Savita Dhongade (Desai). "Synthesis and QSAR Study of Some HDL Cholesterol Increasing Quinazolinone Derivatives." E-Journal of Chemistry 1, no. 1 (2004): 17–31. http://dx.doi.org/10.1155/2004/671567.

Full text

Abstract:

We describe here an easy and efficient method to obtainS-alkylated derivatives of thio-quinazolinone using different alkylating agents via a solvent-free microwave-assisted method. The alkylated thio quinazolinones were further sequentially condensed with hydrazine hydrate and different aromatic aldehydes to get the hydrazones, which were studied for QSAR. The synthesized compounds were subjected to a prediction of biological activities. A software application (PASS) was used for this purpose. The relationship between structure and different biological activities was studied and the different

APA, Harvard, Vancouver, ISO, and other styles

12

Nerkar, A. G., A. K. Saxena, S. A. Ghone, and A. K. Thaker. "In SilicoScreening, Synthesis andIn VitroEvaluation of Some Quinazolinone and Pyridine Derivatives as Dihydrofolate Reductase Inhibitors for Anticancer Activity." E-Journal of Chemistry 6, s1 (2009): S97—S102. http://dx.doi.org/10.1155/2009/506576.

Full text

Abstract:

Dihydrofolate reductase (DHFR) is the important target for anticancer drugs belonging to the class of antimetabolites as the enzyme plays important role in the de novo purine synthesis. We here report thein silicoscreening to obtain best fit molecules as DHFR inhibitors, synthesis of some ʻbest fitʼ quinazolinone from 2-phenyl-3-(substituted-benzilidine-amino) quinazolinones (Quinazolinone Shiff's bases) QSB1-5and pyridine-4-carbohydrazide Shiff's bases (ISB1-5) derivatives and theirin vitroanticancer assay. Synthesis of the molecules was performed using microwave assisted synthesis. The struc

APA, Harvard, Vancouver, ISO, and other styles

13

Zhang, Jinjin, Baohua Huang, Yujing Lu, et al. "Synthesis and Biological Evaluation of Isofebrifugine Analogues." Letters in Organic Chemistry 16, no. 12 (2019): 1004–10. http://dx.doi.org/10.2174/1570178616666190417115639.

Full text

Abstract:

: Isofebrifugine, as a kind of natural quinazolinone alkaloid with important physiological activities and good pharmacological effects, was isolated from a Chinese medicinal plant, Chang Shan (Dichroa febrifuga). In this paper, the synthesis of a series of novel isofebrifugine analogues was accomplished by employing the N-alkylation of 4(3H)-quinazolinones with benzyl (3aR,7aR)-rel-2- (bromomethyl)hexahydrofuro[3,2-b]pyridine-4(2H)carboxylates and the subsequent N-deprotection. These analogues were characterized by 1H NMR, 13C NMR and HRMS spectra. The MTT assay was used to examine the inhibit

APA, Harvard, Vancouver, ISO, and other styles

14

B, Shireesha, G. V. Kumar, V. M. Reddy, Raghuprasad M, and A. R. Rao. "N-Substituted Quinazolin- 2,4-diones as Adenosine Receptor Ligands." International Journal of Pharmaceutical Sciences and Nanotechnology 3, no. 2 (2010): 1015–21. http://dx.doi.org/10.37285/ijpsn.2010.3.2.16.

Full text

Abstract:

Six new N-substituted quinazolinones were synthesized and evaluated for their adenosine antagonistic activity using allergic mice model where 1, 3-dibenzyl and 1, 3-dibutyl-quinazolindiones were found to be potent than 1, 3-dimethylanalogues. They were not significant in controlling the neutrophil and lymphocyte count but effective in controlling the eosinophil influx. In adenosine receptor binding studies, 1,3-dimethyl and 1,3-dibutyl derivatives were found to have significant adenosine A1 receptor binding efficiency with Ki values 9nM and 10nM, respectively, while 1,3- dibenzyl-quinazolinone

APA, Harvard, Vancouver, ISO, and other styles

15

Shafii, Behnaz, Mina Saeedi, Mohammad Mahdavi, Alireza Foroumadi, and Abbas Shafiee. "Novel Four-Step Synthesis of Thioxo-quinazolino[3,4-a]quinazolinone Derivatives." Synthetic Communications 44, no. 2 (2013): 215–21. http://dx.doi.org/10.1080/00397911.2013.800211.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

MOHAMMADHOSSEINI, Negar, Mina SAEEDI, Shahram MORADI, et al. "Synthesis and cytotoxicity of novel thioxo-quinazolino[3,4-$a$]quinazolinones." TURKISH JOURNAL OF CHEMISTRY 41 (2017): 125–34. http://dx.doi.org/10.3906/kim-1512-80.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

REDDY, G. M., and P. S. N. REDDY. "ChemInform Abstract: Bisazaheterocyclics. Part 5. Synthesis of Some Quinazolinonyl/Benzodiazepinonyl-quinazolinones." ChemInform 29, no. 48 (2010): no. http://dx.doi.org/10.1002/chin.199848156.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Gong, Tang, Liu та Liu. "Synthesis and Evaluation of Novel 2H-Benzo[e]-[1,2,4]thiadiazine 1,1-Dioxide Derivatives as PI3Kδ Inhibitors". Molecules 24, № 23 (2019): 4299. http://dx.doi.org/10.3390/molecules24234299.

Full text

Abstract:

In previous work, we applied the rotation-limiting strategy and introduced a substituent at the 3-position of the pyrazolo [3,4-d]pyrimidin-4-amine as the affinity element to interact with the deeper hydrophobic pocket, discovered a series of novel quinazolinones as potent PI3Kδ inhibitors. Among them, the indole derivative 3 is one of the most selective PI3Kδ inhibitors and the 3,4-dimethoxyphenyl derivative 4 is a potent and selective dual PI3Kδ/γ inhibitor. In this study, we replaced the carbonyl group in the quinazolinone core with a sulfonyl group, designed a series of novel 2H-benzo[e][1

APA, Harvard, Vancouver, ISO, and other styles

19

Mohammadhosseini, Negar, Shahram Moradi, Mehdi Khoobi, and Abbas Shafiee. "Synthesis of Novel 6-Mercapto-12-phenethyl-quinazolino[3,4-a]quinazolinones." Journal of Heterocyclic Chemistry 53, no. 5 (2015): 1595–602. http://dx.doi.org/10.1002/jhet.2470.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Amrutkar, Rakesh D., Sunil V. Amrutkar, and Mahendrasing S. Ranawat. "Quinazolin-4-One: A Varsatile Molecule." Current Bioactive Compounds 16, no. 4 (2020): 370–82. http://dx.doi.org/10.2174/1573407215666181120115313.

Full text

Abstract:

Background:Quinazolines and quinazolinones constitute a major class of biologically active molecules both from natural and synthetic sources. We will limit this review to compounds possessing the 4(3H)-quinazolinone skeleton, which is found in compounds displaying significant biological and pharmacological properties. The molecular design of potential lead compound is still a key line of approach for the discovery and development of new chemical entities. A combination of two or more chemical moieties into one is a common approach of operation and this can most likely result in the improvement

APA, Harvard, Vancouver, ISO, and other styles

21

Shafii, Behnaz, Mina Saeedi, Mohammad Mahdavi, Alireza Foroumadi, and Abbas Shafiee. "ChemInform Abstract: Novel Four-Step Synthesis of Thioxo-quinazolino[3,4-a]quinazolinone Derivatives." ChemInform 45, no. 24 (2014): no. http://dx.doi.org/10.1002/chin.201424178.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Fekri, Leila Z. "NiFe2O4@SiO2 @amino Glucose Magnetic Nanoparticle under Solvent-free Condition: A New, mild, Simple and Effective Avenue for the Synthesis of Quinazolinone, Imidazo[1,2-a]Pyrimidinone and Novel Derivatives of Amides." Current Organic Synthesis 17, no. 4 (2020): 304–12. http://dx.doi.org/10.2174/1570179417666200409151330.

Full text

Abstract:

Background: Imidazo[1,2-a]pyrimidinone, quinazolinone and amide derivatives have attracted a lot of interest because of their broad scope of biological and pharmacological activities. There are a lot of methods reported in the literature for their synthesis. Therefore, we became interested in developing a convenient synthetic method for the preparation of imidazoquinazolinone and amide derivatives. Objective: NiFe2O4@SiO2 @glucose amine were synthesized, characterized and have been used for the green, effective and mild multicomponent synthesis of quinazolinones, benzoimidazo[1,2-a]pyrimidinon

APA, Harvard, Vancouver, ISO, and other styles

23

Allen, Eric E., Stephen E. de Laszlo, Song X. Huang, et al. "Quinazolinones 1: design and synthesis of potent quinazolinone- containing AT1-selective angiotensin-II receptor antagonists." Bioorganic & Medicinal Chemistry Letters 3, no. 6 (1993): 1293–98. http://dx.doi.org/10.1016/s0960-894x(00)80334-0.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Ozaki, Ken-ichi, Yoshihisa Yamada, Toyonari Oine, Tōru Ishizuka, and Yoshio Iwasawa. "Studies on 4(1H)-Quinazolinones. 5. Synthesis and Antiinflammatory Activity of 4(1H)-Quinazolinone Derivatives." Journal of Medicinal Chemistry 28, no. 5 (1985): 568–76. http://dx.doi.org/10.1021/jm50001a006.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Salahuddin, Nehal, Ahmed A. Elbarbary, and Hend A. Alkabes. "Quinazolinone Derivatives Loaded Polypyrrole/Chitosan Core–Shell Nanoparticles with Different Morphologies: Antibacterial and Anticancer Activities." Nano 12, no. 01 (2017): 1750002. http://dx.doi.org/10.1142/s1793292017500023.

Full text

Abstract:

Polypyrrole/chitosan (PPC) spherical dark nanoparticles surrounded by shadow spheres were fabricated through in situ oxidative polymerization of pyrrole in presence of chitosan (CS) using ferric chloride (FeCl3) as oxidant and evaluated as a carrier for some amino-quinazolinone derivatives (I–IV). The loading of amino-quinazolinone derivatives (I–IV) into the core–shell nanoparticles were investigated by thermal gravimetric analysis (TGA). Quinazolinone derivatives (I–IV) loaded nanoparticles showed inter-connected sphere in necklace-like morphology, rods or filaments depending on the function

APA, Harvard, Vancouver, ISO, and other styles

26

Sharma, Moni, Shashi Pandey, Kuldeep Chauhan, Deepty Sharma, Brijesh Kumar, and Prem M. S. Chauhan. "Cyanuric Chloride Catalyzed Mild Protocol for Synthesis of Biologically Active Dihydro/Spiro Quinazolinones and Quinazolinone-glycoconjugates." Journal of Organic Chemistry 77, no. 2 (2012): 929–37. http://dx.doi.org/10.1021/jo2020856.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Kshirsagar, U. A. "Recent developments in the chemistry of quinazolinone alkaloids." Organic & Biomolecular Chemistry 13, no. 36 (2015): 9336–52. http://dx.doi.org/10.1039/c5ob01379h.

Full text

Abstract:

This review focuses on the recent advances in the chemistry of quinazolinone alkaloids which covers the newly isolated quinazolinone alkaloids with their biological activities and the recently reported total syntheses of quinazolinone alkaloids from 2006 to 2015.

APA, Harvard, Vancouver, ISO, and other styles

28

Fišnerová, Ludmila, Bohumila Brunová, Zuzana Kocfeldová, Jana Tíkalová, Eva Maturová, and Jaroslava Grimová. "Synthesis and analgetic efficiency of some oxy and oxo derivatives of 4(3H)-quinazolinone." Collection of Czechoslovak Chemical Communications 56, no. 11 (1991): 2373–81. http://dx.doi.org/10.1135/cccc19912373.

Full text

Abstract:

A series of 3-substituted 4(3H)-quinazolinone derivatives have been prepared by alkylation of 4(3H)-quinazolinone with halogenoethers, halogenoketones, and Mannich bases, and the products have been tested for analgetic effects.The most interesting representatives of the oxy and oxo derivatives are 3-[2-(2’,4’-difluoro-4-biphenylyloxy)ethyl]-4(3H)-quinazolinone (Ib) and 3-[2-oxo-2-(4-biphenylyl)ethyl]-4(3H)-quinazolinone (IIi), respectively. Among the group of oxy derivatives also the 2-methylderivative Ig has been prepared, viz. by alkylation of 2’,4’-difluoro-4-hydroxybiphenyl with 2-methyl-3

APA, Harvard, Vancouver, ISO, and other styles

29

Hricovíniová, Jana, Zuzana Hricovíniová, and Katarína Kozics. "Antioxidant, Cytotoxic, Genotoxic, and DNA-Protective Potential of 2,3-Substituted Quinazolinones: Structure—Activity Relationship Study." International Journal of Molecular Sciences 22, no. 2 (2021): 610. http://dx.doi.org/10.3390/ijms22020610.

Full text

Abstract:

The evaluation of antioxidant compounds that counteract the mutagenic effects caused by the direct action of reactive oxygen species on DNA molecule is of considerable interest. Therefore, a series of 2,3-substituted quinazolinone derivatives (Q1–Q8) were investigated by different assays, and the relationship between their biological properties and chemical structure was examined. Genotoxicity and the potential DNA-protective effects of Q1–Q8 were evaluated by comet assay and DNA topology assay. Antioxidant activity was examined by DPPH-radical-scavenging, reducing-power, and total antioxidant

APA, Harvard, Vancouver, ISO, and other styles

30

Mercaldi, Gustavo F., Americo T. Ranzani, and Artur T. Cordeiro. "Discovery of New Uncompetitive Inhibitors of Glucose-6-Phosphate Dehydrogenase." Journal of Biomolecular Screening 19, no. 10 (2014): 1362–71. http://dx.doi.org/10.1177/1087057114546896.

Full text

Abstract:

The enzyme glucose-6-phosphate dehydrogenase (G6PDH) catalyzes the first step of the oxidative branch of the pentose phosphate pathway, which provides cells with NADPH, an essential cofactor for many biosynthetic pathways and antioxidizing enzymes. In Trypanosoma cruzi, the G6PDH has being pursued as a relevant target for the development of new drugs against Chagas disease. At present, the best characterized inhibitors of T. cruzi G6PDH are steroidal halogenated compounds derivatives from the mammalian hormone precursor dehydroepiandrosterone, which indeed are also good inhibitors of the human

APA, Harvard, Vancouver, ISO, and other styles

31

Hricovíniová, Jana, Zuzana Hricovíniová, and Katarína Kozics. "Antioxidant, Cytotoxic, Genotoxic, and DNA-Protective Potential of 2,3-Substituted Quinazolinones: Structure—Activity Relationship Study." International Journal of Molecular Sciences 22, no. 2 (2021): 610. http://dx.doi.org/10.3390/ijms22020610.

Full text

Abstract:

The evaluation of antioxidant compounds that counteract the mutagenic effects caused by the direct action of reactive oxygen species on DNA molecule is of considerable interest. Therefore, a series of 2,3-substituted quinazolinone derivatives (Q1–Q8) were investigated by different assays, and the relationship between their biological properties and chemical structure was examined. Genotoxicity and the potential DNA-protective effects of Q1–Q8 were evaluated by comet assay and DNA topology assay. Antioxidant activity was examined by DPPH-radical-scavenging, reducing-power, and total antioxidant

APA, Harvard, Vancouver, ISO, and other styles

32

Zeng, Fanlong, and Howard Alper. "One-Step Synthesis of Quinazolino[3,2-a]quinazolinones via Palladium-Catalyzed Domino Addition/Carboxamidation Reactions." Organic Letters 12, no. 16 (2010): 3642–44. http://dx.doi.org/10.1021/ol101428v.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Abdel-Alim, Abdel-Alim M., Abdel-Nasser A. El-Shorbagi, Mahmoud A. El-Gendy, and Hosny A. H. El-Shareif. "Quinazolinone Derivatives of Biological Interest V. Novel 4(3H)-Quinazolinones with Sedative-Hypnotic, Anticonvulsant and Antiinflammatory Activities." Collection of Czechoslovak Chemical Communications 58, no. 8 (1993): 1963–68. http://dx.doi.org/10.1135/cccc19931963.

Full text

Abstract:

2-Methyl-4(3H)-quinazolines carrying alkyl, cycloalkyl, aralkyl or aryl substituents at N-3 of the quinazoline ring exhibit analgetic, antipyretic and antiinflammatory activities comparable to those of aspirin and phenylbutazone. In our previous work, various 4(3H)-quinazoline derivatives were prepared. The present communication is a continuation of our effort in this field.

APA, Harvard, Vancouver, ISO, and other styles

34

Ghosh, Prasanjit, Bhaskar Ganguly, and Sajal Das. "C–H functionalization of quinazolinones by transition metal catalysis." Organic & Biomolecular Chemistry 18, no. 24 (2020): 4497–518. http://dx.doi.org/10.1039/d0ob00742k.

Full text

Abstract:

Quinazolinone and its derivatives are an important class of heterocyclic scaffolds in pharmaceuticals and natural products. This review provides the recent research advances in the transition metal catalyzed selective C–H bond functionalization of quinazolinone.

APA, Harvard, Vancouver, ISO, and other styles

35

Ghosh, Suman Kr, and Rajagopal Nagarajan. "NIS-mediated regioselective amidation of indole with quinazolinone and pyrimidone." RSC Adv. 4, no. 39 (2014): 20136–44. http://dx.doi.org/10.1039/c4ra02417f.

Full text

Abstract:

A mild, metal-free condition was developed for the direct regioselective C2 amidation of indoles and pyrroles with quinazolinone and pyrimidone derivatives in intermolecular fashion, which led to novel indolyl/pyrrolyl quinazolinone and pyrimidone derivatives in moderate to good yields.

APA, Harvard, Vancouver, ISO, and other styles

36

El-Sayed, Amira A., Mahmoud F. Ismail, Abd El-Galil E. Amr, and Ahmed M. Naglah. "Synthesis, Antiproliferative, and Antioxidant Evaluation of 2-Pentylquinazolin-4(3H)-one(thione) Derivatives with DFT Study." Molecules 24, no. 20 (2019): 3787. http://dx.doi.org/10.3390/molecules24203787.

Full text

Abstract:

The current study was chiefly designed to examine the antiproliferative and antioxidant activities of some novel quinazolinone(thione) derivatives 6–14. The present work focused on two main points; firstly, comparing between quinazolinone and quinazolinthione derivatives. Whereas, antiproliferative (against two cell lines namely, HepG2 and MCF-7) and antioxidant (by two methods; ABTS and DPPH) activities of the investigated compounds, the best quinazolinthione derivatives were 6 and 14, which exhibited excellent potencies comparable to quinazolinone derivatives 5 and 9, respectively. Secondly,

APA, Harvard, Vancouver, ISO, and other styles

37

Peter Osarodion Osarumwense, Mary Olire Edema, and Cyril Odianosen Usifoh. "Synthesis and antibacterial activities of quinazolin-4(3h)-one, 2-methyl-4(3h)-quinazolinone and 2–phenyl-4(3h)-quinazolinone." International Journal of Biological and Pharmaceutical Sciences Archive 1, no. 2 (2021): 077–84. http://dx.doi.org/10.30574/ijbpsa.2021.1.2.0027.

Full text

Abstract:

Background: Quinazoline and quinazolinone scaffolds represent an important class of biologically active nitrogen heterocyclic compounds. Many marketed drugs are based on these moieties. A diverse range of molecules with quinazoline/quinazolinone moieties have been reported to exhibit broad spectrum of biological activities Objective: This study is aimed at the synthesis of these quinazolinone derivatives, quinazolin-4(3H)-One, 2-Methyl-4(3H)-quinazolinone and 2–Phenyl-4(3H)-quinazolin-4(3H)–one and evaluate them for their antibacterial activities. Method: The consolidation of 2-amino-methyl-4-

APA, Harvard, Vancouver, ISO, and other styles

38

USIFOH, C. O. "3-Propynyl-2-substituted Carboxylic Acid Derivatives of Quinazolinone." Scientia Pharmaceutica 68, no. 3 (2000): 275–79. http://dx.doi.org/10.3797/scipharm.aut-00-25.

Full text

Abstract:

Alkylation of quinazolinone-2-carboxylic acids with propargyl bromide in dimethylformamide in the presence of potassium carbonate afforded 3-prop-2-ynyl quinazolinone-2-substituted carboxylic acid derivatives. Further reaction of 4b-c produced 5b-c, which indicates that N-alkylation occurs before esterification with a propynyl moiety.

APA, Harvard, Vancouver, ISO, and other styles

39

Zeng, Fanlong, and Howard Alper. "ChemInform Abstract: One-Step Synthesis of Quinazolino[3,2-a]quinazolinones via Palladium-Catalyzed Domino Addition/Carboxamidation Reactions." ChemInform 41, no. 51 (2010): no. http://dx.doi.org/10.1002/chin.201051161.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Heidari, Ali, Arash Ghorbani-Choghamarani, Maryam Hajjami, and Robert H. E. Hudson. "Fluorescent Biaryl Uracils with C5-Dihydro- and Quinazolinone Heterocyclic Appendages in PNA." Molecules 25, no. 8 (2020): 1995. http://dx.doi.org/10.3390/molecules25081995.

Full text

Abstract:

There has been much effort to exploit fluorescence techniques in the detection of nucleic acids. Canonical nucleic acids are essentially nonfluorescent; however, the modification of the nucleobase has proved to be a fruitful way to engender fluorescence. Much of the chemistry used to prepare modified nucleobases relies on expensive transition metal catalysts. In this work, we describe the synthesis of biaryl quinazolinone-uracil nucleobase analogs prepared by the condensation of anthranilamide derivatives and 5-formyluracil using inexpensive copper salts. A selection of modified nucleobases we

APA, Harvard, Vancouver, ISO, and other styles

41

Shelat, C. D., and R. T. Vashi. "Synthesis, Characterization, Chelating Properties and Anti-Fungal Activity of 2-(4-Phenylpiperazinyl) Methyl-3-(8-Quinolinol-5-YL)- 4(3H)-Quinazolinone." E-Journal of Chemistry 2, no. 1 (2005): 86–90. http://dx.doi.org/10.1155/2005/973414.

Full text

Abstract:

A new quinazolinone derivative namely 2-(4-phenylpiperazinyl)methyl-3-(8-quinolinol-5-yl)- 4(3h)-quinazolinone(HL) was prepared and characterized. Various transition metal (Cu2+, Co2+, Ni2+, Zn2+, Mn2+) chelates of HL were prepared and characterized by metal ligand (M:L) ratio, IR and reflectance spectral studies, magnetic moment, and antimicrobial activity.

APA, Harvard, Vancouver, ISO, and other styles

42

Abu-Hashem, Ameen. "Synthesis of New Furothiazolo Pyrimido Quinazolinones from Visnagenone or Khellinone and Antimicrobial Activity." Molecules 23, no. 11 (2018): 2793. http://dx.doi.org/10.3390/molecules23112793.

Full text

Abstract:

Substituted-6-methyl-1-thioxo-1,2-dihydro-3H-furo[3,2-g]pyrimido[1,6-a]quinazolin-3-ones (5a,b) were synthesized from condensation of visnagenone (2a) or khellinone (2b) with 6-amino-thiouracil (3) in dimethylformamide or refluxing of (4a) or (4b) in dimethylformamide. Hence, compounds (5a,b) were used as the starting materials for preparing many new heterocyclic compounds such as; furo[3,2-g]pyrimido[1,6-a]quinazoline (6a,b), furo[3,2-g]thiazolo[2′,3′:2,3]pyrimido[1,6-a]quinazolinone (7a,b), substituted-benzylidene-furo[3,2-g]thiazolo[2′,3′:2,3]pyrimido[1,6-a]quinazoline-3,5-dione (8a–f), 3-o

APA, Harvard, Vancouver, ISO, and other styles

43

Bhavesh, Amrute B., Amrutkar D. Rakesh, and Tambe R. Santosh. "Design and Molecular Docking Studies of Some 2,3 Di-Substituted Quinazolin-4-One Analogues Against Staphylococcus aureus UDG." Current Computer-Aided Drug Design 16, no. 4 (2020): 402–6. http://dx.doi.org/10.2174/1573409915666190916100437.

Full text

Abstract:

Background: In this present investigation, some 2, 3 disubstituted-quinazolin-4-one derivatives are designed and docked against chain A and chain B of (3WDF) receptor. Methods: The heterocyclic fused rings quinazolinone have drawn a great attention owing to their expanded applications in the field of pharmaceutical chemistry. The diverse range of molecules with quinazoline/quinazolinone moieties have been reported to exhibit a broad spectrum of biological activities. Results: The results designate that the quinazolinone ring forms hydrophobic and hydrogen bond contacts with ASN 127 A, ALA 126

APA, Harvard, Vancouver, ISO, and other styles

44

ABDEL-ALIM, A. A. M., A. N. A. EL-SHORBAGI, M. A. EL-GENDY, and H. A. H. EL-SHAREIF. "ChemInform Abstract: Quinazolinone Derivatives of Biological Interest. Part 5. Novel 4(3H)- Quinazolinones with Sedative-Hypnotic, Anticonvulsant and Antiinflammatory Activities." ChemInform 24, no. 50 (2010): no. http://dx.doi.org/10.1002/chin.199350244.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Khachatryan, D. S., V. A. Misyurin, M. A. Baryshnikova, N. V. Golubtsova, A. V. Kolotaev, and K. R. Matevosyan. "Quinazolinon derivatives for the treatment of neoplastic, parasitic and neurodegenerative diseases." Russian Journal of Biotherapy 16, no. 3 (2017): 32–42. http://dx.doi.org/10.17650/1726-9784-2017-16-3-32-42.

Full text

Abstract:

In this review we discuss some biological activities of quinazolinon derivatives. The derivatives of quinazolinon possess their activity by binding to some proteins important for the survival, proliferation and metastasis of tumor cells. There are grounds to initiate clinical trials of these substances to create new treatment protocols for a wide range of cancer diseases, several parasitic diseases, and certain neurodegenerative diseases.

APA, Harvard, Vancouver, ISO, and other styles

46

Patel, Sachin, Manish Patel, and Ranjan Patel. "Synthesis and characterization of heterocyclic substituted fluoran compounds." Journal of the Serbian Chemical Society 72, no. 11 (2007): 1039–44. http://dx.doi.org/10.2298/jsc0711039p.

Full text

Abstract:

New quinazolinone-substituted fluoran compounds were synthesized by reaction of keto acid, 2?-carboxy-2-hydroxy-4-N-pyrrolidinylbenzophenone with different quinazolinone derivatives in the presence of conc. sulphuric acid. All the synthesized fluoran compounds were characterized by spectroscopic methods (IR, 1H-NMR and UV-visible spectroscopy) and elemental analysis. The fluoran compounds are colorless or nearly colorless and develop color on contact with electron-accepting compounds.

APA, Harvard, Vancouver, ISO, and other styles

47

Abdel-Megeed, Mohamed Farghali, and Abderrahman Teniou. "Synthesis of some 3-substituted 4(3H)-quinazolinone and 4(3H)-quinazolinethione derivatives and related fused biheterocyclic ring systems." Collection of Czechoslovak Chemical Communications 53, no. 2 (1988): 329–35. http://dx.doi.org/10.1135/cccc19880329.

Full text

Abstract:

The reactions of 2-phenyl-4(3H)-quinazoline, 2-phenyl-3-amino-4(3H)-quinazolinone, and corresponding thiones with phenyl isocyanate or phenyl isothiocyanate were investigated. The resulting urea and thiourea quinazolinone or quinazolinethione derivatives reacted with hydrazine hydrate, phenylhydrazine, and urea or thiourea to form fused biheterocyclic ring systems with potential biological activities. The products were identified by IR, 1H NMR, and mass spectroscopy.

APA, Harvard, Vancouver, ISO, and other styles

48

Osarumwense, Peter O. "Analgesic activity of newly synthesized 7-chloro–2–methyl-4H–benzo[d] [1,3]–oxazin–4–one and 3–amino-7-chloro-2–methyl-quinazolin-4(3H)–one." Ovidius University Annals of Chemistry 29, no. 1 (2018): 25–28. http://dx.doi.org/10.2478/auoc-2018-0003.

Full text

Abstract:

Abstract The current study is aimed at the analgesic evaluation of quinazolinone derivatives. The quinazolinone derivatives 7-chloro-2-methyl-4H-benzo[d][1,3]-oxazin-4-one and 3-amino-7-chloro-2-methyl-quinazolin-4(3H)-one were evaluated pharmacologically for their in vivo analgesic activities by acetic acid induced writhing in mice. The compounds exhibited significant analgesic activity in the range of 74.67 - 83.80% in comparison to control.

APA, Harvard, Vancouver, ISO, and other styles

49

Osarumwense, P. O., M. O. Edema, and C. O. Usifoh. "Synthesis And Anagesic activities of Quinazolin-4(3H)-One, 2-Methyl-4(3H)-Quinazolinone and 2–Phenyl-4(3H)-quinazolin-4(3H)–one." Journal of Drug Delivery and Therapeutics 10, no. 4-s (2020): 87–91. http://dx.doi.org/10.22270/jddt.v10i4-s.4209.

Full text

Abstract:

Background: Objective: The current study is aimed at the synthesis of these quinazolinone derivatives quinazolin-4(3H)-One, 2-Methyl-4(3H)-quinazolinone and 2–Phenyl-4(3H)-quinazolin-4(3H)–one and evaluate them for their analgesic activity. Method: The condensation of 2-amino-methyl-4-methoxybenzoate with acetic anhydride yielded the cyclic compound 2-methyl-4, 5-disubstituted-1, 3-benzo-oxazine-4-one which further produce a novel 2,3-disubstituted quinazolin-4 ones via the reaction with hydrazine hydrate The quinazolinone derivatives quinazolin-4(3H)-One, 2-Methyl-4(3H)-quinazolinone and 2–Ph

APA, Harvard, Vancouver, ISO, and other styles

50

Yadav, Meena K., Laxmi Tripathi, and Diptendu Goswami. "SYNTHESIS AND ANTICONVULSANT ACTIVITY (CHEMO SHOCK) OF N-1(SUBSTITUTED-N-4[(4-OXO-3-PHENYL-3, 4-DIHYDRO-QUINAZOLINE-2-YLMETHYL) SEMICARBAZONES." Asian Journal of Pharmaceutical and Clinical Research 10, no. 4 (2017): 359. http://dx.doi.org/10.22159/ajpcr.2017.v10i4.16876.

Full text

Abstract:

Objective: This work is designed at finding new structure leads with potential anticonvulsant activities of 4(3H)-quinazolinone pharmacophore scaffold.Methods: A new series of 4(3H)-quinazolinone pharmacophore was designed with substituted moieties possesses different electronic environment in the hope of developing potent and safe new effective compounds. In such fashion, in this paper, we report the synthesis and anticonvulsant activity (Chemo shock) of N-1(substituted-N-4[(4-oxo-3-phenyl-3, 4-dihydro-quinazoline-2-ylmethyl) semicarbazones 3A-d (1-7), 3B-d (1-7), 3C-d (1-7), their chemical s

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!