Academic literature on the topic 'Quinazolinone derivatives'

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Journal articles on the topic "Quinazolinone derivatives"

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Deng, Zhijiang, Jieming Li, Pengbo Zhu, et al. "Quinazolinones as Potential Anticancer Agents: Synthesis and Action Mechanisms." Biomolecules 15, no. 2 (2025): 210. https://doi.org/10.3390/biom15020210.

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Quinazolinones, essential quinazoline derivatives, exhibit diverse biological activities with applications in pharmaceuticals and insecticides. Some derivatives have already been developed as commercial drugs. Given the rising cancer incidence, there is a critical need for new anticancer agents, and quinazolinones show promising potential in this domain. The present review focuses on novel advances in the synthesis of these important scaffolds and other medicinal aspects involving drug design, the structure–activity relationship, and action mechanisms of quinazoline and quinazolinone derivativ
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Asif, Mohammad. "Chemical Characteristics, Synthetic Methods, and Biological Potential of Quinazoline and Quinazolinone Derivatives." International Journal of Medicinal Chemistry 2014 (November 13, 2014): 1–27. http://dx.doi.org/10.1155/2014/395637.

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The heterocyclic fused rings quinazoline and quinazolinone have drawn a huge consideration owing to their expanded applications in the field of pharmaceutical chemistry. Quinazoline and quinazolinone are reported for their diversified biological activities and compounds with different substitutions bring together to knowledge of a target with understanding of the molecule types that might interact with the target receptors. Quinazolines and quinazolinones are considered as an important chemical for the synthesis of various physiological significance and pharmacological utilized molecules. Quin
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Barat, Gaman G., and Mahesh R. Solanki. "Antimicrobial Study of Novel Triazoles Synthesized from Chalcones." Oriental Journal Of Chemistry 40, no. 3 (2024): 794–98. http://dx.doi.org/10.13005/ojc/400322.

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Heterocyclic compound such as quinazoline derivatives shows wide range of medicinal application in the area such as anticonvulsant, antitumor, antifungal, antimalaria, anti-hyperlipidemic and anti-inflammatory etc. activity because of these it shows great interest to study. In the presence study, we have synthesized triazole based quinazolinones by condensation reaction between α-methyl ketone and aromatic aldehydes under ethanol as the solvent to produced chalcones derivatives. This chalcone derivative have α, β-unsaturated part which is enhanced the reactivity of compound. Chalcone further r
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Starikova, Alla Andreevna, Alexandra Aleksandrovna Tsibizova, and Marina Aleksandrovna Samotrueva. "BIOLOGICAL ACTIVITY OF NATURAL QUINAZOLINE ALKALOIDS." Chemistry of plant raw material, no. 2 (May 4, 2025): 47–73. https://doi.org/10.14258/jcprm.20250214908.

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To date, quinazoline alkaloids of natural origin, as well as synthetic derivatives based on them, whose structure contains an aromatic heterocyclic system including a pyrimidine cycle and a benzoin ring connected to it, are promising according to the criterion of the optimal profile of pharmacological activity. Currently, several hundred compounds of the quinazoline nature have been identified with a wide range of biological activities, including psychotropic (antidepressant, antipsychotic, sedative, hypnotic, anticonvulsant, etc.), antiplatelet, hypotensive, anti-inflammatory, antioxidant and
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Vishwakarma, Lav Kush Kumar, and Varsha Kashaw. "Nanocatalyzed Synthetic Approach for the Quinazolinone and Quinazoline Derivatives: A Review (2015 – Present)." Journal of Drug Delivery and Therapeutics 13, no. 3 (2023): 171–83. http://dx.doi.org/10.22270/jddt.v13i3.5765.

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Due to their diverse chemical reactivities and essential range of biological action, quinazolines and their derivatives rank among the most significant heterocyclic compounds. Quinazoline and quinazolinone scaffolds pharmacological properties have sparked medicinal chemists' interest in creating original medications or drug candidates. The growth of quinazoline hybrid lead compounds and the related heterocycles is summarised in the current review of medicinal chemistry. Additionally, by shedding light on the potential significance of these hybridised pharmacophoric characteristics in the demon
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Prakash, Gaurav, Ajay Kumar Das, and V. D. Tripathi. "A Catalyst Free and Sustainable Synthesis of Quinazolinones in Glycerol as Green Solvent." Asian Journal of Chemistry 35, no. 5 (2023): 1089–94. http://dx.doi.org/10.14233/ajchem.2023.27612.

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In this article, glycerol was employed in a quest to develop an environmentally benign and sustainable synthetic protocol for synthesis of quinazolinone and spiro-quinazolinone derivatives. These studies were performed to investigate the effect of electron-rich and electronegative groups on the synthetic route of an established protocol. Different substituted isatin and benzaldehyde derivatives have been incorporated to synthesize analogues of two series of quinazolinones in order to investigate the efficacy of the developed methodology and substrate tolerance. A total of 12 derivatives were s
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Mishra, AD. "A New Route for the Synthesis of Quinazolinones." Nepal Journal of Science and Technology 12 (July 22, 2012): 133–38. http://dx.doi.org/10.3126/njst.v12i0.6491.

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Quinazolinone derivatives are highly bioactive heterocyclic compounds with wider range of microbial activities such as anti-malarial, anti-cancer, anti-inflammatory, anti-hypertensive, anti-convulsant, anti-HIV, etc. Solid supported microwave synthesis of some 3-substituted-4-(2H)-quinazolinones has been carried out by the reaction of anthranilic acid, formaldehyde and primary aromatic amines. The usage of hazardous reagents and organic solvents has been avoided. The reactions were conducted in presence of acidic alumina where formaldehyde entered into cycloaddition to yield the quinazolinone
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Jianghong, Man, Qi Jianbin, Jiang Jie, and Li Sha. "Microwave Reaction Improved Heterocyclization of Quinazolinone Ring in Synthesis of Erlotinib Analogues." Journal of Pharmaceutical and Biomedical Sciences 10, no. 05 (2020): 99–105. https://doi.org/10.1234/zenodo.3876.

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Background Tinibs were a kind of important epidermal growth factor receptor (EGFR) inhibitors used as potential therapeutic agents in treating non-small cell lung cancer (NSCLC) in clinic. The drug resistance of clinical used tinibs made the development of more active tinib analogues an attractive field in research. Quinazoline ring was regarded as the key fragment in tinibs and quinazolinone was indispensible intermediate in the synthesis of quinazoline. Thus, synthesis of quinazolinone intermediates was a key step which would further limit the overall yield of final product of tinib analogue
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Yaduwanshi, Phool Singh, Sheelu Singh, Prinsi Sahapuriya, Priyanka Dubey, Jyoti Thakur, and Savita Yadav. "Synthesis of Some Noval Qunazolinone Derivatives for their Anticonvulsant Activity." Oriental Journal Of Chemistry 40, no. 2 (2024): 369–73. http://dx.doi.org/10.13005/ojc/400207.

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The quinoline family comprises an appealing group of heterocyclic compounds, with quinazolinones and their synthetic analogs being of particular interest. To synthesize 3- amino 2-phenyl quinazolinones, anthranilic acid and its substituted derivatives were employed as initial materials. The MES method was utilized to evaluate the anticonvulsant activity of the developed substances on albino mice, with phenytoin serving as a benchmark anticonvulsant medication.The synthesized compounds demonstrated noteworthy anticonvulsant activity, comparable to that of established prescription medications. A
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Abdel-Megeed, Mohamed Farghali, and Abderrahman Teniou. "Synthesis of some 3-substituted 4(3H)-quinazolinone and 4(3H)-quinazolinethione derivatives and related fused biheterocyclic ring systems." Collection of Czechoslovak Chemical Communications 53, no. 2 (1988): 329–35. http://dx.doi.org/10.1135/cccc19880329.

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The reactions of 2-phenyl-4(3H)-quinazoline, 2-phenyl-3-amino-4(3H)-quinazolinone, and corresponding thiones with phenyl isocyanate or phenyl isothiocyanate were investigated. The resulting urea and thiourea quinazolinone or quinazolinethione derivatives reacted with hydrazine hydrate, phenylhydrazine, and urea or thiourea to form fused biheterocyclic ring systems with potential biological activities. The products were identified by IR, 1H NMR, and mass spectroscopy.
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Dissertations / Theses on the topic "Quinazolinone derivatives"

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Li, Jiyang [Verfasser]. "Investigation of Phthalazine, Quinazoline and Pyrimidine Derivatives as ABCG2 Inhibitors / Jiyang Li." Bonn : Universitäts- und Landesbibliothek Bonn, 2018. http://d-nb.info/1167857135/34.

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Krapf, Michael [Verfasser]. "Investigation of Quinazoline Derivatives as Inhibitors of Breast Cancer Resistance Protein (BCRP/ABCG2) / Michael Krapf." Bonn : Universitäts- und Landesbibliothek Bonn, 2018. http://d-nb.info/1160594155/34.

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Cardoso, Leandro 1979. "Utilização farmacológica de um composto inédito derivado de quinazolina como inibidor potencial da quinase de adesão focal (FAK) no processo de hipertrofia cardíaca em camundongo = Pharmacological use of a novel compound quinazoline derivative as potential inhibitor of the focal adhesion kinase in the process of cardiac hypertrophy in mice." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310205.

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Orientador: Kleber Gomes Franchini<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-20T23:08:02Z (GMT). No. of bitstreams: 1 Cardoso_Leandro_M.pdf: 3831901 bytes, checksum: 40e5df211d7e6fd923f654bd8d3a1ec1 (MD5) Previous issue date: 2012<br>Resumo: Nas doenças do coração ocorre hipertrofia e remodelamento do ventrículo esquerdo com impacto negativo na evolução clínica. Esses fatores influenciam independentemente o risco cardiovascular por elevarem a predisposição a infartos do miocárdio, ao desenvolvimento de
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LIN, CHUN-HUNG, and 林俊宏. "Study of Quinazolinone Derivatives on Enhancement of Anticancer Drugs Activity." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/30968119740447194201.

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碩士<br>國立臺灣大學<br>藥學系研究所<br>86<br>ABSTRACT We have evaluated the effect of the quinazolinone derivatives on P-glycoprotein-mediated MDR in breast cancer by performing an in vitro cytotoxicity assay and flow cytometry. The cell lines employed for this study were human breast cancer cells selected for resistance to adriamycin, MCF7/adr, and its counterpart, wildtype MCF7. Compared with the sensitivity of the wildtype and adr-resistant cells, the MCF7/adr subline showed more th
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Lo, Chi-Chun, and 羅吉鈞. "Synthesis and pharmacological evaluation of 4(3H)quinazolinone derivatives as potencial angiotensin II antagonists." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/58461088283823970919.

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Hour, Mann-Jen, and 侯曼貞. "Synthesis, Cytotoxicity and Antiplatelet Activity of 6,7,2',3',4',5'-Substituted 2-phenyl-4-quinazolinone Derivatives." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/66215076548891573814.

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博士<br>中國醫藥學院<br>藥物化學研究所<br>88<br>As part of our continuing search for potential anticancer candidates of 2-phenyl-4-quinazolinones and 2-phenyl-4-quinolones, two series of 6,7,2',3',4',5'-substituted 2-phenyl-4-quinazolinones and 6,2',3',4',5'-substituted 2,3-dihydro-2-phenyl-4-quinazolinones have been synthesized and evaluated for cytotoxicity and inhibition of tubulin polymerization. Through these biological screening, a preliminary structure-activity relationship has been established. On the whole, a good correlation was found between the two activities. Among them, 6-N,N-dimethylamino and
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Liu, Chih-Fa, та 劉誌發. "design and synthesis of quinazolinone and 1,2-benzothiazine 1,1-dioxide derivatives as potential selective α1A-adrenoceptor antagonists". Thesis, 2000. http://ndltd.ncl.edu.tw/handle/59531007520783388600.

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碩士<br>國立臺灣大學<br>藥學研究所<br>88<br>This study is aimed to synthesize two series of compounds, namely, substituted arylpiperazinyl benzothiazinone 1,1-dioxide (A) and substituted arylpiperazinyl quinazolinone (B) derivatives for evaluation of α1A adrenoceptor selectivity and are considered to be potential for treatment of benign prostatic hyperplasia (BPH). The synthesis of compounds in A series started from esterification of 3,4-dimethoxyphenyl acetic acid (25) in methanol with a catalytic amount of concentrated sulfuric acid to give 3,4-dimethoxy-1-(carbomethoxymethyl)benzene (26). T
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Lu, Chi-Cheng, and 呂啟誠. "Investigations for targeting signaling pathways in the apoptosis induction and anti-metastasis of the novel quinazolinone derivatives in leukemia and oral cancer cells in vitro and anti-tumor activity in vivo." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/69439994355722115199.

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博士<br>國立中興大學<br>生命科學系所<br>100<br>The previous studies have demonstrated that 2-phenyl 6-pyrrolidinyl-4-quinazolinone derivatives exhibited antitumor actions and biological responses. Among them, both of the most potent newly synthesized compounds, 6-pyrrolidinyl-2-(2-hydroxyphenyl)-4-quinazolinone (MJ-29) and 6-pyrrolidinyl- 2-(3-Methoxyphenyl)-4-quinazolinone (HMJ-38) for their mechanisms underlying anticancer activities remain unclear and have not been well clarified. In this dissertation, we attempt to investigate anti-leukemia and anti-oral cancer effects in vitro and in vivo. In the chapt
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Li, Hong-Bin, and 李鴻斌. "Study of 4-(Substitutedphenylamino)Quinazoline Derivatives." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/12061863258573308290.

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碩士<br>文化大學<br>應用化學系<br>85<br>The objective of this thesis is to investigate the synthesis of 4-(substitutedphenylamino)quinazoline derivatives. Because the C4-C8 sites of the compound with different substituents are able to be used as tyrosine kinase inhibitors.In the study,it consist of three synthetic processes.Firstly,the starting material, monochloroanthranilic acid and dichloroanthranilic acid reacted with formamide in high temperature and refluxed to give mono- and di-chloro substitut
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Huang, Ya-Ping, and 黃雅蘋. "Synthesis and Antiproliferative Evaluation of Substituted Quinazoline Derivatives." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/29298330647027420014.

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碩士<br>高雄醫學大學<br>醫藥暨應用化學研究所<br>100<br>Quinazoline derivatives have been found to possess a wide variety of biological activities. The aims of this thesis are to synthesize and evaluate a series of 4-substituted and 2-substituted-vinyl quinazoline derivatives. These 4-substituted and 2-substituted-vinyl quinazoline derivatives with various substituents at the C-4 position of quinazoline skeleton and at the vinyl moiety have been synthesized and evaluated for their antiproliferatve activities. Results indicated that most of these newly synthesized compounds exhibited potent activities against the
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Books on the topic "Quinazolinone derivatives"

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Gamal Al-kaf, Ali, ed. Quinazolinone and Quinazoline Derivatives. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.85315.

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Book chapters on the topic "Quinazolinone derivatives"

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Dangi, R. R., N. S. Chundawat, and K. L. Ameta. "Synthesis and Biological Evaluation of Some Quinazoline Heterocyclic Derivatives." In Green Chemistry: Synthesis of Bioactive Heterocycles. Springer India, 2014. http://dx.doi.org/10.1007/978-81-322-1850-0_13.

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Gamal Al-kaf, Ali. "Introductory Chapter: The Newest Research in Quinazolinone and Quinazoline Derivatives." In Quinazolinone and Quinazoline Derivatives. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.88913.

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Chiriţă, Cornel, Carmen Limban, Diana Camelia Nuţă, et al. "Synthesis and Pharmacological Research Regarding New Compounds with Quinazolin-4-One Structure." In Quinazolinone and Quinazoline Derivatives. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.89164.

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E. Hashem, Heba. "Synthesis of Quinazoline and Quinazolinone Derivatives." In Quinazolinone and Quinazoline Derivatives. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.89180.

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Mishra, Satyendra. "Quinazolinone and Quinazoline Derivatives: Synthesis and Biological Application." In Quinazolinone and Quinazoline Derivatives. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.89203.

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Bhanudas Zangade, Sainath. "Quinazoline Based Synthesis of some Heterocyclic Schiff Bases." In Quinazolinone and Quinazoline Derivatives. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.89871.

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Y. Abbas, Samir. "4(3H)-Quinazolinone Derivatives: Syntheses, Physical Properties, Chemical Reaction, and Biological Properties." In Quinazolinone and Quinazoline Derivatives. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.90104.

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A. Radwan, Awwad, and Fars K. Alanazi. "Biological Activity of Quinazolinones." In Quinazolinone and Quinazoline Derivatives. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.90621.

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Bhat, Mahesh, S. L. Belagali, S. V. Mamatha, B. K. Sagar, and E. Vijaya Sekhar. "Importance of quinazoline and quinazolinone derivatives in medicinal chemistry." In Studies in Natural Products Chemistry. Elsevier, 2021. http://dx.doi.org/10.1016/b978-0-323-91095-8.00005-2.

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Wahan, Simranpreet K., Sangeeta Sharma, and Pooja A. Chawla. "2 Synthesis of quinazolinone and quinazoline derivatives using green chemistry approach." In Synthesis of Bioactive Scaffolds. De Gruyter, 2022. http://dx.doi.org/10.1515/9783110797428-002.

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Conference papers on the topic "Quinazolinone derivatives"

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Al-Majedy, Yasmien, Ahmed Al-Amiery, and Redha Al-Bayati. "Novel quinazolinone derivatives: Synthesis and Antimicrobial Activity." In The 14th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2010. http://dx.doi.org/10.3390/ecsoc-14-00413.

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Rammohan, Aluru, and Grigory V. Zyryanov. "Synthesis and characterization of 1,2,3-triazole integrated quinazolinone derivatives." In PROCEEDINGS OF INTERNATIONAL CONFERENCE ON RECENT TRENDS IN MECHANICAL AND MATERIALS ENGINEERING: ICRTMME 2019. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0018182.

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Maleki, Ali, Jamal Rahimi, and Razieh Firouzi Haji. "Green synthesis of quinazolinone derivatives by using a recyclable heteropoly acid catalyst." In The 21st International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2017. http://dx.doi.org/10.3390/ecsoc-21-04722.

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Maleki, Ali, and Nakisa Ghamari. "A three-component one-pot procedure for the synthesis benzimidazolo-quinazolinone derivatives in the presence of chitosan-supported metal nanocomposite as a green and reusable catalyst." In The 17th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2013. http://dx.doi.org/10.3390/ecsoc-17-a034.

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Naimi-Jamal, Mohammad Reza, and Maryam karimi. "A simple, convenient three component one-pot procedure for the synthesis of benzimidazolo-quinazolinone derivatives in the presence Silica-based sulfonic acid (MCM-41-SO3H): a efficient and practical catalyst." In The 19th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2015. http://dx.doi.org/10.3390/ecsoc-19-a001.

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Guerreiro Souzedo, Gabriela, LJUBICA TASIC, and Caio Henrique Nasi De Barros. "Synthesis of Quinazoline Derivatives for Adenosine Kinase Inhibition." In XXV Congresso de Iniciação Cientifica da Unicamp. Galoa, 2017. http://dx.doi.org/10.19146/pibic-2017-78452.

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Militaru, Andra, Adriana Smarandache, Abdallah Mahamoud, et al. "Stability Characterization of Quinazoline Derivative BG1188 by Optical Methods." In ADVANCES IN LASEROLOGY - SELECTED PAPERS OF LASER FLORENCE 2010: The 50th Birthday of Laser Medicine World. AIP, 2011. http://dx.doi.org/10.1063/1.3626907.

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Hussein, AL-Shaimaa Anas, and Fawzi Hameed Jumaa. "Preparation and evaluation of quinazoline derivatives as antimicrobial agents and liquid crystals." In 4TH INTERNATIONAL CONFERENCE ON INNOVATION IN IOT, ROBOTICS AND AUTOMATION (IIRA 4.0). AIP Publishing, 2025. https://doi.org/10.1063/5.0254204.

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Yen, Shih Chieh, Shao-Zheng Peng, Hung-Jyun Huang, et al. "Abstract 2809: Novel 2,5,8-trihydro-6,7-disubstituted-4-(3'-alkylsulfonamidoanilino) quinazoline derivatives as RAF inhibitor." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-2809.

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Ayvazyan, A. S., A. I. Markosyan, F. H. Arsenyan, and Kh S. Hakobyan. "SYNTHESIS AND BIOLOGICAL ACTIVITY OF SPIRO[BENZO[H]QUINAZOLINE-5,1’-CYCLOHEPTANE]- 4(6H)-ONE DERIVATIVES." In MedChem-Russia 2021. 5-я Российская конференция по медицинской химии с международным участием «МедХим-Россия 2021». Издательство Волгоградского государственного медицинского университета, 2021. http://dx.doi.org/10.19163/medchemrussia2021-2021-240.

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