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Relevant bibliographies by topics / Quinine alkaloids

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Journal articles

Academic literature on the topic 'Quinine alkaloids'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 February 2022

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Journal articles on the topic "Quinine alkaloids"

1

Griffin, Carol E., Jonathan M. Hoke, Upeka Samarakoon, et al. "Mutation in the Plasmodium falciparum CRT Protein Determines the Stereospecific Activity of Antimalarial Cinchona Alkaloids." Antimicrobial Agents and Chemotherapy 56, no. 10 (2012): 5356–64. http://dx.doi.org/10.1128/aac.05667-11.

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ABSTRACTTheCinchonaalkaloids are quinoline aminoalcohols that occur as diastereomer pairs, typified by (−)-quinine and (+)-quinidine. The potency of (+)-isomers is greater than the (−)-isomersin vitroandin vivoagainstPlasmodium falciparummalaria parasites. They may act by the inhibition of heme crystallization within the parasite digestive vacuole in a manner similar to chloroquine. Earlier studies showed that a K76I mutation in the digestive vacuole-associated protein, PfCRT (P. falciparumchloroquine resistance transporter), reversed the normal potency order of quinine and quinidine towardP.

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2

Horie, Masao, Mitsuo Oishi, Fusako Ishikawa, et al. "Liquid Chromatographic Analysis of Cinchona Alkaloids in Beverages." Journal of AOAC INTERNATIONAL 89, no. 4 (2006): 1042–47. http://dx.doi.org/10.1093/jaoac/89.4.1042.

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Abstract A method for the determination of Cinchona extract (whose main components are the alkaloids cinchonine, cinchonidine, quinidine, and quinine) in beverages by liquid chromatography was developed. A beverage with an alcohol content of more than 10% was loaded onto an OASIS HLB solid-phase extraction cartridge, after it was adjusted to pH 10 with 28% ammonium hydroxide. Other beverages were centrifuged at 4000 rpm for 5 min, and the supernatant was loaded onto the cartridge. The cartridge was washed with water followed by 15% methanol, and the Cinchona alkaloids were eluted with methanol

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3

Eyal, Sara. "The Fever Tree: from Malaria to Neurological Diseases." Toxins 10, no. 12 (2018): 491. http://dx.doi.org/10.3390/toxins10120491.

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This article describes the discovery and use of the South American cinchona bark and its main therapeutic (and toxic) alkaloids, quinine and quinidine. Since the introduction of cinchona to Europe in the 17th century, it played a role in treating emperors and peasants and was central to colonialism and wars. Over those 400 years, the medical use of cinchona alkaloids has evolved from bark extracts to chemical synthesis and controlled clinical trials. At the present time, the use of quinine and quinidine has declined, to a large extent due to their toxicity. However, quinine is still being pres

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4

Dubey, Anubhav, and Yatendra Singh. "Medicinal Properties of Cinchona Alkaloids - A Brief Review." Asian Journal of Research in Pharmaceutical Sciences 11, no. 3 (2021): 224–28. http://dx.doi.org/10.52711/2231-5659.2021.00036.

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Cinchona which belongs to family Rubiaceae, got its importance from the centuries because of its anti- malarial activity. Alkaloids present in this herb, Quinine, Chichonine, Quinidine and Cinchonidine are the main, but percentage may vary in species to species. Since the early 17th century, these alkaloid are frequently used in Indian ayurvedic, sidha and traditional folk medicine to treating fever and Still now in modern medicine cinchona alkaloids are used for the treatment of malaria as well as for other diseases and became the well-known drug after the treatment of malaria caused by Plasm

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5

Montagnac, A., M. Litaudon, and M. País. "Quinine- and quinicine-derived alkaloids from Guettarda noumeana." Phytochemistry 46, no. 5 (1997): 973–75. http://dx.doi.org/10.1016/s0031-9422(97)00358-0.

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6

Malchow, R. P., H. Qian, and H. Ripps. "A novel action of quinine and quinidine on the membrane conductance of neurons from the vertebrate retina." Journal of General Physiology 104, no. 6 (1994): 1039–55. http://dx.doi.org/10.1085/jgp.104.6.1039.

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The cinchona alkaloids quinine and quinidine have been shown to block a broad range of voltage-gated membrane conductances in a variety of excitable tissues. Using the whole-cell version of the patch clamp technique, we examined the effects of these compounds on voltage-dependent currents from horizontal cells dissociated enzymatically from the all-rod retina of the skate. We report here a novel and unexpected action of quinine and quinidine on isolated horizontal cells. In addition to blocking several of the voltage-activated currents of these cells, the introduction of the alkaloids evoked a

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7

Ratnadewi, Diah. "Strictosidine Synthase Coding Gene Expression towards Quinine Biosynthesis and Accumulation: Inconsistency in Cultured Cells and Fresh Tissues of Cinchona ledgeriana." International Journal of Agriculture and Biology 26, no. 01 (2021): 131–38. http://dx.doi.org/10.17957/ijab/15.1817.

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Strictosidine synthase, encoded by the gene STR, facilitates the regeneration of strictosidine, a critical intermediate for the synthesis of many plant alkaloids. The gene has, however, never been studied in Cinchona spp. The plants produce quinine alkaloid used for malaria medication, SARS-CoV-2 treatment and other industrial purposes. Cultured cells can produce the alkaloid but only at a much lower yield than the natural tree. This study describes STR expression and quinine content in various plant materials. Bioinformatic analyses were conducted on nine species of Rubiaceae to obtain refere

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8

Brittain, Harry G. "Vibrational Spectroscopic Study of the Cocrystal Products Formed by Cinchona Alkaloids with 5-Nitrobarbituric Acid." Journal of Spectroscopy 2015 (2015): 1–13. http://dx.doi.org/10.1155/2015/340460.

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X-ray powder diffraction, differential scanning calorimetry, infrared absorption spectroscopy, and Raman spectroscopy have been used to study the phenomenon of cocrystal formation in the molecular complexes formed by 5-nitrobarbituric acid with four cinchona alkaloids. The cocrystal products were found to contain varying degrees of hydration, ranging from no hydration in the nitrobarbiturate-quinidine cocrystal up to a 4.5-hydrate species in the nitrobarbiturate-cinchonine cocrystal. For the nitrobarbiturate cocrystals with cinchonine, cinchonidine, and quinidine, the predominant interaction w

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9

Sanders, Natalie G., David J. Meyers, and David J. Sullivan. "Antimalarial Efficacy of Hydroxyethylapoquinine (SN-119) and Its Derivatives." Antimicrobial Agents and Chemotherapy 58, no. 2 (2013): 820–27. http://dx.doi.org/10.1128/aac.01704-13.

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ABSTRACTQuinine and other cinchona-derived alkaloids, although recently supplanted by the artemisinins (ARTs), continue to be important for treatment of severe malaria. Quinine and quinidine have narrow therapeutic indices, and a safer quinine analog is desirable, particularly with the continued threat of antimalarial drug resistance. Hydroxyethylapoquinine (HEAQ), used at 8 g a day for dosing in humans in the 1930s and halving mortality from bacterial pneumonias, was shown to cure bird malaria in the 1940s and was also reported as treatment for human malaria cases. Here we describe synthesis

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10

Pratiwi, Dian Rahma, Yohana Caecilia Sulistyaningsih, and Diah Ratnadewi. "Localization of Alkaloid and Other Secondary Metabolites in Cinchona ledgeriana Moens: Anatomical and Histochemical Studies on Fresh Tissues and Cultured Cells." HAYATI Journal of Biosciences 27, no. 1 (2020): 1. http://dx.doi.org/10.4308/hjb.27.1.1.

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Cinchona ledgeriana produces several secondary metabolites. The main quinoline alkaloid, quinine that is widely used as an antimalarial drug, is most commonly extracted from the bark of Cinchona, and its leaves contain several other metabolites. Many studies have revealed that cell culture of Cinchona also produces quinine. Nevertheless, the sites of secondary metabolites accumulation are still elusive. This study is aimed at describing specific anatomical structures where alkaloids and some other secondary metabolites are accumulated as well as their localization in leaves and barks of C. led

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