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1

Hunt, Thomas. "Application of phosphorus-centred radicals towards the synthesis of (-)-quinine and related analogues." Thesis, University of York, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428405.

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2

Ji, An. "Mn-mediated radical coupling toward synthesis of alpha, alpha-disubstituted alpha-amino esters and formal synthesis of quinine." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/1150.

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Chiral alpha-branched amines are common substructures of bioactive synthetic targets such as alkaloids and amino acids. Direct asymmetric amine synthesis by addition to the C=N bond of carbonyl imino derivatives is promising and efficient to introduce the stereogenic center and carbon-carbon bond in one step. Furthermore, disconnection of either C-C bond at the amine stereogenic center would be the most versatile method to achieve this objective; we could make the choice depending on the different synthetic strategies, such as the availability of precursors and the presence of complicating str
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3

Oosthuizen, Francois Jacobus. "Syntheses of the Enantiopure Quinones A and A' and Their C-1 Epimers." Murdoch University, 2002. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20040820.123649.

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The 3,4-dihydro-1H-naphtho[2,3-c]pyran ring system is found in many natural products as the 5,10- or 6,9-quinones. These compounds have been synthesized by various research groups as a result of their wide range of biological activities. This thesis describes several investigations directed towards syntheses of compounds in this general area. Quinone A (16) and quinone A’(17), derived from the naturally occurring aphid insect pigments protoaphin-fb and protoaphin-sl respectively, were of particular interest. The first chapter describes the previous syntheses of some naphtho[c]pyrans including
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4

Arshad, Muhammad. "Syntheses of quinine and quinidine using sulfur ylide epoxidation reaction as a key step." Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.535226.

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5

Rafipoor, Fereshteh. "Synthesis of oxindole quinones and carboline quinones." Thesis, Brunel University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292445.

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6

Cossette, Michael Vernie. "The Synthesis of Quinone-Capped Cyclodextrins." W&M ScholarWorks, 1988. https://scholarworks.wm.edu/etd/1539625451.

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7

Moya, Eduardo. "Ortho-quinone methides from the pyrolysis of substituted benzyltriphenylphosphonium compounds." Thesis, University of Kent, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235694.

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8

Chilloux, Aurelie Amelia. "Synthesis of anticancer heterocyclic quinones." Thesis, University of Nottingham, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.537637.

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9

Barr, Stephen Alexander. "Quinoline alkaloids : synthesis and stereochemistry." Thesis, Queen's University Belfast, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333796.

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10

Jacob, Aouregan Michèle Marguerite Simone. "Synthesis of naturally occurring quinones." Thesis, University of Nottingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437087.

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11

Taljaard, Jana Heloïse. "Synthesis, properties and reactions of Novel Quinone Methides." Thesis, Nelson Mandela Metropolitan University, 2007. http://hdl.handle.net/10948/616.

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Novel p-quinone methides have been synthesized by the dealkylation of 5-(p-alkyloxyaryl)- 10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ols and related compounds. Aspects of the dealkylation reaction were investigated using computational methods in order to identify possible intermediates and postulate reasons for the observed reactivity patterns. This included studying the effect of varying the size of the central B-ring, changing the alkyloxy group, and altering the substitution pattern on the parent alcohols. We have assessed the relative energies of reaction intermediates and have also evalua
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12

Klaas, Phindile Jonathan. "Novel approaches to the synthesis of quinoline derivatives." Thesis, Rhodes University, 2001. http://hdl.handle.net/10962/d1004751.

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The investigation has been concerned with the application of the Baylis-Hillman methodology to the synthesis of quinoline derivatives. An extensive range of novel Baylis-Hillman products has been prepared, typically in moderate to excellent yields, by condensing 2-nitrobenzaldehyde derivatives with various vinyl ketones and acrylic esters in the presence of diazabicyclo[2.2.2]octane (DABCO). Reduction of the nitro group in the Baylis-Hillman products was effected by catalytic hydrogenation in ethanol using a 10% palladium-on-carbon catalyst to afford quinoline, quinoline-N-oxide and quinolone
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13

Roberts, Lezah Wilette. "The synthesis of a tetracene quinone phosphoramidite photosensitizer to study charge migration through DNA." Thesis, Georgia Institute of Technology, 2001. http://hdl.handle.net/1853/30903.

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14

Mei, Mawonga N. "A model route to a brominated hydroxy[2,3-c]pyran- a potential precursor to extended quinones." Thesis, Cape Peninsula University of Technology, 2008. http://hdl.handle.net/20.500.11838/749.

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A thesis submitted in fulfilment of the requirements for the degree Magister Technologiae (Chemistry) in the Faculty of Applied Sciences, Department of Chemistry, Cape Peninsula University of Technology, 2008<br>Green et al. attempted to synthesize linear naphthopyranquinones from a naphthyl dioxolane using a TiCl4 as a catalyst. They managed to synthesise an angular naphthopyran as well as a linear naphthopyran in low yield. They showed that reducing the steric strain at position 1 of the naphthyl dioxolane afforded a low percentage yield of the linear naphthopyran plus an angular one. This t
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15

Nielsen, Linda Birgitta. "Synthesis of some naturally occurring quinones." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2008. http://theses.library.uwa.edu.au/adt-WU2009.0067.

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Naturally occurring quinones have attracted considerable interest due to their widespread occurrence, structural diversity and often potent biological activities. The research outlined in this thesis involves the development of synthetic approaches to two novel naphthoquinone derivatives, both of which were discovered during investigations into the bioactive constituents of tropical plant species. Chapter 1 introduces the family of quinonoid compounds and also considers the important role that natural product synthesis can play in structural confirmation and in providing an adequate supply of
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16

Soper, R. J. "The synthesis and biological activities of natural quinone metabolites." Thesis, University of Essex, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.402818.

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17

McGaw, Oliver. "Studies towards the novel synthesis of benzoisochromane quinone polyketides." Thesis, University of East Anglia, 2014. https://ueaeprints.uea.ac.uk/58538/.

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Granaticin is a structurally unique member of the benzoisochromane quinone (BIQ) family of antibiotics. The molecule and its derivative exhibit a sugar moiety fusted to the naphthazarin core, only exhibited by one other natural compound, by a C-C glycosidic bond and an aldol like bond. The mechanism of enzymatic attachment of this substituent is currently unknown. This project aimed to devise a novel and elegant synthesis towards the granaticin aglycone and other benzoisochromane quinone natural compounds with the long term aim of discerning the mechanism of glycosylation. This thesis shows a
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18

Eralp, Tugce. "Synthesis Of Ferrocenyl Quinones And Polyquinanes." Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/3/12606205/index.pdf.

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ABSTRACT SYNTHESIS OF FERROCENYL QUINONES AND POLYQUINANES Eralp, Tug&ccedil<br>e M.S., Department of Chemistry Supervisor: Assoc. Prof. Dr. Metin Zora June 2005, 79 pages With the discovery of antitumor activity of ferrocene derivatives, research on new ferrocene derivatives have gained importance. For this purpose, we have investigated the synthesis of ferrocenyl quinones starting from squaric acid. Several quinone derivatives are known to have antitumor and antibiotic activities. In this research, by combining ferrocene and quinone moieties, we have targeted ferrocenyl quinones whi
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19

Visconti, Andrea. "Synthesis of quinones with anticancer activity." Thesis, University of Nottingham, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.574662.

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Quinones attract the attention of chemists and biologists because of their unique structure and biological properties. Cancer is a leading cause of death worldwide, killing millions of people every year. Several antitumour agents, frequently employed in the treatment of different forms of cancer, contain in their structure the quinone motif, discovered to have marked cytotoxic effects. Chapter 1 presents an overview of the unique properties of quinones, with particular emphasis on their anticancer activity. Bioactivation of quinones by cellular reductive enzymes generates reactive oxygen speci
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20

Loper, John T. "Synthesis of novel bis(bioreductive) alkylating agents /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487266011225016.

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21

Martin, Claire Marie. "Synthesis and bioactivation of redox-activated quinone prodrugs of guanidine." Thesis, Bangor University, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.568210.

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This thesis describes the preparation of several novel guanidine derivatives (where X= tetrarnethyl, dipiperidine and dimorpholine); three containing a previously described trimethyl-substituted quinone I and three analogous guanidines containing the novel phenyl-substituted quinone H. These conformationally locked derivatives were tested as substrates in a benzoquinone-based drug delivery system which is activated by the enzyme human quinone-oxidoreductase I (hNQOI). Molecular modelling studies were initially performed and demonstrated that all six derivatives were viable substrates of the en
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22

Raghvani, Dinesh V. "Studies of 1,2-quinone monooximes and their use in synthesis." Thesis, London Metropolitan University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300685.

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23

Dollberg, Christopher Lawrence. "Zinc and ruthenium quinone diimine complexes synthesis and photophysical properties /." Columbus, Ohio Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1071171484.

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Thesis (Ph. D.)--Ohio State University, 2003.<br>Title from first page of PDF file. Document formatted into pages; contains xvii, 171 p.; also includes graphics (some col.). Includes abstract and vita. Advisor: Claudia Turro, Dept.of Chemistry. Includes bibliographical references (p. 168-171).
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24

Dollberg, Christopher L. "Zinc and ruthenium quinone diimine complexes: synthesis and photophysical properties." The Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=osu1071171484.

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25

Neville, Charles Frederick. "The synthesis and biosynthesis of quinoline alkaloids." Thesis, University of Ulster, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.481119.

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26

Ramdohr, Jurgen Ernst. "Synthesis of naphtho{2,3-c}pyrans including the aphin-derived quinone A'." Master's thesis, University of Cape Town, 1987. http://hdl.handle.net/11427/15896.

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Bibliography: pages 76-78.<br>Chapter One describes the synthesis of a trifluoroethylnaphtho-1, 4-quinone via a regiospecific trifluoroacetylation of an appropriately substituted naphthalene. Chapter Two describes the synthesis of the methyl ethers of the naturally occurring quinones A and deoxyquinone A for evaluation of their "anti-cancer" activity by the National Institutes of Health. In Chapter Three the final few steps of the synthesis of the aphid-derived quinone A' are described. This was made possible by the development of an efficient route for the conversion of a precursor to quinone
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27

Haddad, Jalal. "Synthesis and chemistry of some quinoline-5,8-diones." Virtual Press, 1994. http://liblink.bsu.edu/uhtbin/catkey/917048.

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The synthesis of several 7-substituted analogs of 2-methylquinoline-5,8-dione and their chemistry are described. In this investigation the following compounds were prepared.5,7-Diformamido-8-hydroxy-2-methylquinoline (207), 7-formamido-2methylquinoline-5,8-dione (199), 7-acetamido-2-methylquinoline-5,8-dione (6), 7-isobutyramido-2-methylquinoline-5,8-dione (200), 7-amino-2-methylquinoline-5,8-dione (210), 7-amino-6-chloro-2-methylquinoline-5,8-dione (213), 7-methoxy-2-methylquinoline5,8-dione (214), 7-ethoxy-2-methylquinoline-5,8-dione (215), 7-isopropyloxy-2methylquinoline-5,8-dione (216), 7-
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28

李智輝 and Chi-fai Lee. "Synthesis of hibiscoquinone C and experiments in the synthesis of other naturally occurring quinones." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1996. http://hub.hku.hk/bib/B31213285.

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29

Watters, William Henry. "Studies towards the synthesis of hemiterpenoid quinoline alkaloids." Thesis, University of Ulster, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241684.

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30

Velioglu, Ozlem. "Synthesis Of Ferrocenyl Substituted Quinolines." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/3/12609785/index.pdf.

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Quinolines have been studied for over a century as an important class of heterocyclic compounds and continue to attract considerable interest due to the broad range of biological activities they possess. The incorporation of the essential structural features of quinolines with a ferrocene moiety could provide new derivatives with unexpected and/or enhanced biological activities since several ferrocene derivatives have already been shown to be active against a number of tumors. For this reason, we investigated the synthesis of ferrocenyl-substituted quinolines, such as 2-ferrocenylquinoline, by
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31

Franjesevic, Andrew Joseph. "Design, Synthesis, and Evaluation of Therapeutics for the Treatment of Organophosphorus Poisoning by Nerve Agents and Pesticides." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1563349257142378.

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32

Waugh, T. M. "Synthesis of quinone anticancer agents and substituted bicyclo[3.3.1]nonane-2,9-diones." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1566735/.

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Current quinone anticancer agents such as the anthracyclines are polycyclic conjugated molecules which, whilst effective at treating many forms of cancer, their severe side effects such as cumulative heart toxicity often limit their use. A previously identified single ring anticancer quinone HU-331 was synthesised from cannabidiol and shown to be highly efficacious against several human cancer cell lines and in a comparative animal study was found to be less toxic and more effective than the commonly used doxorubicin. HU-331 has also been identified as a selective catalytic inhibitor of DNA to
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33

Chakrabarti, Jayatibha. "Metal complexes of 1,2 quinone monooximes and their applications in organic synthesis." Thesis, London Metropolitan University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294986.

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Systematic investigations of the reactions of 1,2-quinone monooximes (qoH) with alkali (lithium, sodium and potassium) and alkaline earth metal (magnesium and barium) hydroxides and acetates [M(OH)n or M(OAc)r] have been carried out. In the case of 1,2-naphthaquinone 1-oxime (1-nqoH) and 1,2-naphthaquinone 2-oxime (2- nqoH), all the alkali metals form complexes of types M(qo). nS and M(qo)(qoH)(S) [S = H20 or EtOH]. M(qo). nS arises when a reactant molar ratio [MOH: qoH] of 1: 1 is used whereas M(qo)(qoH)(S) is formed when the ratio is 1: 2 or 1: 3. An analogous behaviour is also observed in t
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34

Loebach, Jennifer L. "Total synthesis of Dan Shen diterpenoid quinones ; Synthesis and chemistry of (triakylsilyl)vinylketens." Thesis, Massachusetts Institute of Technology, 1995. http://hdl.handle.net/1721.1/32159.

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35

Banini, Serge R. "Palladium-catalyzed syntheses of indoles, pyrroloindoles, quinolines a base-mediated formation of N-alkoxyindoles, and progress toward the first total synthesis of echinosulfone A /." Morgantown, W. Va. : [West Virginia University Libraries], 2008. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5710.

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Thesis (Ph. D.)--West Virginia University, 2008.<br>Title from document title page. Document formatted into pages; contains xv, 275 p. : ill. Includes abstract. Includes bibliographical references (p. 107-113).
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36

Melis, Diana. "Quinoline-triazole half-sandwich iridium(III) complexes: Synthesis, antiplasmodial activity and preliminary transfer hydrogenation studies." Master's thesis, Faculty of Science, 2020. http://hdl.handle.net/11427/32414.

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Malaria is a devastating and pervasive infectious disease and continues to be a major global health issue, with over half the world's population being at risk of transmission. In the absence of a suitable vaccine, efforts to eradicate the disease rely heavily on clinically available drugs. Plasmodium falciparum, the deadliest species of malaria, has however become resistant to most conventional antimalarial treatments, resulting in the worldwide search for new, effective drugs. Amongst other requirements, these drugs should target resistant parasitic strains in an attempt to curb the escalatio
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37

Stern, Alan Joseph. "Synthesis and studies of silyl-methyl ketals of quinones /." The Ohio State University, 1988. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487595712158183.

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38

Curtis, A. D. M. "The development of sugar-based quinones for asymmetric synthesis." Thesis, University of Manchester, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.679590.

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39

Bar, Grégory L. J. "Manganese(III) acetate-mediated radical reactions in organic synthesis." Thesis, University of York, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274499.

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40

Kokturk, Mustafa. "Synthesis Of Ferrocenylidene Cyclopentenediones." Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/12606316/index.pdf.

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SYNTHESIS OF FERROCENYLIDENE CYCLOPENTENEDIONES K&ouml<br>kt&uuml<br>rk, Mustafa M.S., Department of Chemistry Supervisor: Assoc. Prof. Dr. Metin Zora August 2005, 83 pages 2-Arylidine-4-cyclopentene-1,3-diones are known to be antitumor agents. Incorporation of the essential structures of such compounds with a ferrocene moiety instead of an aryl group could provide subtances with enhanced antitumor activities since some ferrocene derivatives have already proved to be active against a number of tumors. Thus, we have investigated the squarate-based synthesis of 2-ferrocenylidene-4-cyclope
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41

Atalar, Taner. "Synthetic Strategy Directed Towards The Synthesis Of Bicyclo[3.3.0]octa-3,5,8-triene-2,7-dione." Master's thesis, METU, 2004. http://etd.lib.metu.edu.tr/upload/12605089/index.pdf.

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Although the chemistry of benzenoid and nonbenzenoid quinones have been the subject of extensive theoretical and experimental studies, the extent of our present understanding regarding the geometries and stabilities of quinones of pentalene is meager. After studying the existence of cyclopentadienone and its reactivity as a diene and dienophile in the literature, the study of some related species, particularly the ones with fully unsaturated pentalenic structures were started. In this thesis, the elusive compound bicyclo[3.3.0]octa-3,5,8-triene-2,7-dione was tried to synthesize by using the sy
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42

Lee, Chi-fai. "Synthesis of hibiscoquinone C and experiments in the synthesis of other naturally occurring quinones /." Hong Kong : University of Hong Kong, 1996. http://sunzi.lib.hku.hk/hkuto/record.jsp?B17489647.

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43

Boers, Rutger Bernard. "13C-labeled plastoquinones and ubiquinones for photosynthesis studies : synthesis and characterization /." [S.l. : s.n], 2003. http://catalogue.bnf.fr/ark:/12148/cb40126731q.

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44

Lambropoulos, John. "Synthesis of potent antitumor congeners and prodrugs of quinonoid compounds and alkaloids." Diss., Georgia Institute of Technology, 1994. http://hdl.handle.net/1853/30771.

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45

Acikalin, Serdar. "Synthesis Of Ferrocenyl Quinones And Ferrocenyl Based Burning Rate Catalysts." Master's thesis, METU, 2003. http://etd.lib.metu.edu.tr/upload/1081256/index.pdf.

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Recently, considerable interest has been devoted to the synthesis of new ferrocene derivatives since properly functionalized ferrocene derivatives could be potential antitumor substances. For this purpose, we have investigated the synthesis of ferrocenyl quinones starting from squaric acid. Thermolysis of ferrocenylsubstituted cyclobutenones, which have been prepared from ferrocenyl cyclobutenediones and alkenyllithiums, affords hydroquinones, which furnish, upon oxidation, ferrocenyl quinones. Ferrocenyl cyclobutenediones have been prepared from known cyclobutenediones by nucleophilic additio
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46

Mazzanti, Stefano. "A novel atroposelective strategy for the synthesis of quinoline substrates." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/16660/.

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Among heterocyclic compounds, quinoline scaffold has become an important motif for the development of new pharmacological active compounds. Since the discovery of their antimalarial properties, a large variety of quinolines was found to have interesting physiological activities and displayed attractive applications for pharmaceutical industries. In accordance to the above-mentioned features, a number of methods were developed for their synthesis but enantioselective versions are still lacking in the literature. In the past decades, this question has become even more complex, with the emergenc
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47

Carrière, Marjolaine Brigitte. "Synthesis and reactions of quinones with some possible biological applications." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ32869.pdf.

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48

Hamilton, Lynne. "Synthesis, stereochemistry and reactions of quinoline, isoquinoline and acridine metabolites." Thesis, Queen's University Belfast, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334710.

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49

Loke, P. L. "Chemoenzymatic and chemical synthesis of enantiopure quinoline derivatives and alkaloids." Thesis, Queen's University Belfast, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273295.

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50

Guyan, P. M. "The pulse radiolysis and synthesis of quinones related to adriamycin." Thesis, University of Manchester, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370412.

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