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Relevant bibliographies by topics / Quinoline-3-carboxamide

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Journal articles

Academic literature on the topic 'Quinoline-3-carboxamide'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 February 2022

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Journal articles on the topic "Quinoline-3-carboxamide"

1

Akinboye, Emmanuel S., Ray J. Butcher, Sema Ozturk Yildirim, and John T. Isaacs. "4-Hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[4-(trifluoromethyl)phenyl]-1,2-dihydroquinoline-3-carboxamide." Acta Crystallographica Section E Structure Reports Online 70, no. 3 (2014): o297—o298. http://dx.doi.org/10.1107/s1600536814003031.

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The title compound, C20H17F3N2O4, named tasquinimod, is a second-generation oral quinoline-3-carboxamide analogue, which is currently in phase III clinical trials for the treatment of metastatic prostate cancer. The quinoline unit is almost planar (r.m.s. deviation of fitted atoms = 0.0075 Å). The carboxamide side chain, substituted at position 3, is tilted by 88.07 (7)° to the quinoline plane. Both the methyl and carbonyl groups of this carboxamide side chain are in asynconformation. The 4-(trifluoromethyl)phenyl plane is inclined at 50.62 (17)° to the plane of the carboxamide side chain, and

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2

Grathwol, Christoph W., Nicolas Chrysochos, Benedict J. Elvers, Andreas Link, and Carola Schulzke. "Crystal structure of benzo[h]quinoline-3-carboxamide." Acta Crystallographica Section E Crystallographic Communications 75, no. 12 (2019): 1828–32. http://dx.doi.org/10.1107/s2056989019014440.

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The title compound, C14H10N2O, crystallizes in the monoclinic space group P21/c with four molecules in the unit cell. All 17 non-H atoms of one molecule lie essentially in one plane. In the unit cell, two pairs of molecules are exactly coplanar, while the angle between these two orientations is close to perfectly perpendicular at 87.64 (6)°. In the crystal, molecules adopt a 50:50 crisscross arrangement, which is held together by two nonclassical and two classical intermolecular hydrogen bonds. The hydrogen-bonding network together with off-centre π–π stacking interactions between the pyridine

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3

Govender, Hogantharanni, Chunderika Mocktar, and Neil A. Koorbanally. "Synthesis and Bioactivity of Quinoline-3-carboxamide Derivatives." Journal of Heterocyclic Chemistry 55, no. 4 (2018): 1002–9. http://dx.doi.org/10.1002/jhet.3132.

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4

Ghorab, Mostafa M., and Mansour S. Alsaid. "Anti-breast cancer activity of some novel quinoline derivatives." Acta Pharmaceutica 65, no. 3 (2015): 271–83. http://dx.doi.org/10.1515/acph-2015-0030.

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Abstract To discover new bioactive lead compounds for medicinal purposes, 2-cyano-3-(4-substituted)-N-(quinolin-3-yl) acrylamide derivatives 2–24, chromenes 25, 26 and benzochromenes 27, 28 were synthesized. The structures of the newly synthesized compounds were confirmed by elemental analyses, IR, 1H NMR and 13C NMR spectroscopies. In addition, the structure of compound 1 was confirmed through X-ray crystallography. All the newly synthesized compounds were evaluated for their cytotoxic activity against the breast cancer cell line MCF7. The corresponding 2-cyano-3-(4-hydroxy-3-methoxyphenyl)-N

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5

Borgstr�m, P., I. P. Torres Filho, P. Vajkoczy, K. Strandg�rden, J. Pola�ek, and B. Hartley-Asp. "The quinoline-3-carboxamide Linomide inhibits angiogenesis in vivo." Cancer Chemotherapy and Pharmacology 34, no. 4 (1994): 280–86. http://dx.doi.org/10.1007/bf00686033.

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6

Borgstr�m, P., I. P. Torres Filho, P. Vajkoczy, K. Strandg�rden, J. Pola�ek, and B. Hartley-Asp. "The quinoline-3-carboxamide Linomide inhibits angiogenesis in vivo." Cancer Chemotherapy and Pharmacology 34, no. 4 (1994): 280–86. http://dx.doi.org/10.1007/s002800050142.

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7

Li, Wen-Yan, Xu-Qiong Xiong, Dong-Mei Zhao, et al. "Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors." Molecules 17, no. 5 (2012): 5497–507. http://dx.doi.org/10.3390/molecules17055497.

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8

Helmersson, Sofia, Anette Sundstedt, Adnan Deronic, Tomas Leanderson, and Fredrik Ivars. "Amelioration of Experimental Autoimmune Encephalomyelitis by the Quinoline-3-Carboxamide Paquinimod." American Journal of Pathology 182, no. 5 (2013): 1671–80. http://dx.doi.org/10.1016/j.ajpath.2013.01.032.

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9

Ghorab, Mostafa M., Mansour S. Alsaid, Mohammed S. Al-Dosari, Fatma A. Ragab, Abdullah A. Al-Mishari, and Abdulaziz N. Almoqbil. "Novel quinolines carrying pyridine, thienopyridine, isoquinoline, thiazolidine, thiazole and thiophene moieties as potential anticancer agents." Acta Pharmaceutica 66, no. 2 (2016): 155–71. http://dx.doi.org/10.1515/acph-2016-0016.

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Abstract As a part of ongoing studies in developing new anticancer agents, novel 1,2-dihydropyridine 4, thienopyridine 5, isoquinolines 6–20, acrylamide 21, thiazolidine 22, thiazoles 23–29 and thiophenes 33–35 bearing a biologically active quinoline nucleus were synthesized. The structure of newly synthesized compounds was confirmed on the basis of elemental analyses and spectral data. All the newly synthesized compounds were evaluated for their cytotoxic activity against the breast cancer cell line MCF7. 2,3-Dihydrothiazole-5-carboxamides 27, 25, 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxa

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10

Boros, Fanni, and László Vécsei. "Progress in the development of kynurenine and quinoline-3-carboxamide-derived drugs." Expert Opinion on Investigational Drugs 29, no. 11 (2020): 1223–47. http://dx.doi.org/10.1080/13543784.2020.1813716.

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