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Journal articles on the topic 'Quinoline-3-carboxamide'

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Published: 4 June 2021

Last updated: 16 February 2022

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1

Akinboye, Emmanuel S., Ray J. Butcher, Sema Ozturk Yildirim, and John T. Isaacs. "4-Hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[4-(trifluoromethyl)phenyl]-1,2-dihydroquinoline-3-carboxamide." Acta Crystallographica Section E Structure Reports Online 70, no. 3 (2014): o297—o298. http://dx.doi.org/10.1107/s1600536814003031.

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The title compound, C20H17F3N2O4, named tasquinimod, is a second-generation oral quinoline-3-carboxamide analogue, which is currently in phase III clinical trials for the treatment of metastatic prostate cancer. The quinoline unit is almost planar (r.m.s. deviation of fitted atoms = 0.0075 Å). The carboxamide side chain, substituted at position 3, is tilted by 88.07 (7)° to the quinoline plane. Both the methyl and carbonyl groups of this carboxamide side chain are in asynconformation. The 4-(trifluoromethyl)phenyl plane is inclined at 50.62 (17)° to the plane of the carboxamide side chain, and

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2

Grathwol, Christoph W., Nicolas Chrysochos, Benedict J. Elvers, Andreas Link, and Carola Schulzke. "Crystal structure of benzo[h]quinoline-3-carboxamide." Acta Crystallographica Section E Crystallographic Communications 75, no. 12 (2019): 1828–32. http://dx.doi.org/10.1107/s2056989019014440.

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The title compound, C14H10N2O, crystallizes in the monoclinic space group P21/c with four molecules in the unit cell. All 17 non-H atoms of one molecule lie essentially in one plane. In the unit cell, two pairs of molecules are exactly coplanar, while the angle between these two orientations is close to perfectly perpendicular at 87.64 (6)°. In the crystal, molecules adopt a 50:50 crisscross arrangement, which is held together by two nonclassical and two classical intermolecular hydrogen bonds. The hydrogen-bonding network together with off-centre π–π stacking interactions between the pyridine

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3

Govender, Hogantharanni, Chunderika Mocktar, and Neil A. Koorbanally. "Synthesis and Bioactivity of Quinoline-3-carboxamide Derivatives." Journal of Heterocyclic Chemistry 55, no. 4 (2018): 1002–9. http://dx.doi.org/10.1002/jhet.3132.

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4

Ghorab, Mostafa M., and Mansour S. Alsaid. "Anti-breast cancer activity of some novel quinoline derivatives." Acta Pharmaceutica 65, no. 3 (2015): 271–83. http://dx.doi.org/10.1515/acph-2015-0030.

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Abstract To discover new bioactive lead compounds for medicinal purposes, 2-cyano-3-(4-substituted)-N-(quinolin-3-yl) acrylamide derivatives 2–24, chromenes 25, 26 and benzochromenes 27, 28 were synthesized. The structures of the newly synthesized compounds were confirmed by elemental analyses, IR, 1H NMR and 13C NMR spectroscopies. In addition, the structure of compound 1 was confirmed through X-ray crystallography. All the newly synthesized compounds were evaluated for their cytotoxic activity against the breast cancer cell line MCF7. The corresponding 2-cyano-3-(4-hydroxy-3-methoxyphenyl)-N

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5

Borgstr�m, P., I. P. Torres Filho, P. Vajkoczy, K. Strandg�rden, J. Pola�ek, and B. Hartley-Asp. "The quinoline-3-carboxamide Linomide inhibits angiogenesis in vivo." Cancer Chemotherapy and Pharmacology 34, no. 4 (1994): 280–86. http://dx.doi.org/10.1007/bf00686033.

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6

Borgstr�m, P., I. P. Torres Filho, P. Vajkoczy, K. Strandg�rden, J. Pola�ek, and B. Hartley-Asp. "The quinoline-3-carboxamide Linomide inhibits angiogenesis in vivo." Cancer Chemotherapy and Pharmacology 34, no. 4 (1994): 280–86. http://dx.doi.org/10.1007/s002800050142.

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7

Li, Wen-Yan, Xu-Qiong Xiong, Dong-Mei Zhao, et al. "Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors." Molecules 17, no. 5 (2012): 5497–507. http://dx.doi.org/10.3390/molecules17055497.

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8

Helmersson, Sofia, Anette Sundstedt, Adnan Deronic, Tomas Leanderson, and Fredrik Ivars. "Amelioration of Experimental Autoimmune Encephalomyelitis by the Quinoline-3-Carboxamide Paquinimod." American Journal of Pathology 182, no. 5 (2013): 1671–80. http://dx.doi.org/10.1016/j.ajpath.2013.01.032.

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9

Ghorab, Mostafa M., Mansour S. Alsaid, Mohammed S. Al-Dosari, Fatma A. Ragab, Abdullah A. Al-Mishari, and Abdulaziz N. Almoqbil. "Novel quinolines carrying pyridine, thienopyridine, isoquinoline, thiazolidine, thiazole and thiophene moieties as potential anticancer agents." Acta Pharmaceutica 66, no. 2 (2016): 155–71. http://dx.doi.org/10.1515/acph-2016-0016.

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Abstract As a part of ongoing studies in developing new anticancer agents, novel 1,2-dihydropyridine 4, thienopyridine 5, isoquinolines 6–20, acrylamide 21, thiazolidine 22, thiazoles 23–29 and thiophenes 33–35 bearing a biologically active quinoline nucleus were synthesized. The structure of newly synthesized compounds was confirmed on the basis of elemental analyses and spectral data. All the newly synthesized compounds were evaluated for their cytotoxic activity against the breast cancer cell line MCF7. 2,3-Dihydrothiazole-5-carboxamides 27, 25, 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxa

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10

Boros, Fanni, and László Vécsei. "Progress in the development of kynurenine and quinoline-3-carboxamide-derived drugs." Expert Opinion on Investigational Drugs 29, no. 11 (2020): 1223–47. http://dx.doi.org/10.1080/13543784.2020.1813716.

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11

Tuvesson, H., I. Hallin, M. Ellman, B. Sparre, P. O. Gunnarsson, and J. Seidegård. "In vitrometabolism andin vivopharmacokinetics of quinoline 3-carboxamide derivatives in various species." Xenobiotica 35, no. 3 (2005): 293–304. http://dx.doi.org/10.1080/00498250500066329.

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12

Deeb, Ali, Abdel Naby Essawy, Fathy Yasine, and Rida Fikry. "Pyridazine Derivatives and Related Compounds, Part 3 [1] Some Reactions with 4-Cyano-3(2H)-pyridazinethione." Zeitschrift für Naturforschung B 46, no. 6 (1991): 835. http://dx.doi.org/10.1515/znb-1991-0620.

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The reaction of 5-amino-3,4-diphenylthieno[2,3-c]pyridazine-6-carboxamide 2 with formamide, acetic anhydride and carbon disulphide yielded pyrimido[4′,5′ :4,5]thieno[2,3-c]-pyridazin-4-one derivatives. Pyrimido[4,5-c]pyridazinethione and dithione derivatives were obtained by cyclocondensation of 3-amino-5,6-diphenylpyridazine-4-carbonitrile (8) with phenyl isothiocyanate and carbon disulphide, respectively. Tetrahydropyridazino[3,4-b]-quinoline (11) was prepared by reaction of 8 with cyclohexanone in presence of zinc chloride.

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13

Polo, Efrain, Jorge Trilleras, and Margarita Gutiérrez Cabrera. "N-{4-[(2E)-3-(2H-1,3-Benzodioxol-5-yl)prop-2-enoyl]phenyl}quinoline-3-carboxamide." Molbank 2017, no. 4 (2017): M960. http://dx.doi.org/10.3390/m960.

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14

Gomes, Ligia R., John Nicolson Low, Fernanda Borges, Alexandra Gaspar, and Francesco Mesiti. "The synthesis, crystal structure and Hirshfeld analysis of 4-(3,4-dimethylanilino)-N-(3,4-dimethylphenyl)quinoline-3-carboxamide." Acta Crystallographica Section E Crystallographic Communications 76, no. 2 (2020): 201–7. http://dx.doi.org/10.1107/s2056989020000298.

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The structure of the title quinoline carboxamide derivative, C26H25N3O, is described. The quinoline moiety is not planar as a result of a slight puckering of the pyridine ring. The secondary amine has a slightly pyramidal geometry, certainly not planar. Both intra- and intermolecular hydrogen bonds are present. Hirshfeld surface analysis and lattice energies were used to investigate the intermolecular interactions.

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15

Ravi, Srimadhavi, Sugata Barui, Sivapriya Kirubakaran, Parul Duhan, and Kaushik Bhowmik. "Synthesis and Characterization of Quinoline-3-Carboxamide Derivatives as Inhibitors of the ATM Kinase." Current Topics in Medicinal Chemistry 20, no. 23 (2020): 2070–79. http://dx.doi.org/10.2174/1568026620666200731174216.

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Background: The importance of inhibiting the kinases of the DDR pathway for radiosensitizing cancer cells is well established. Cancer cells exploit these kinases for their survival, which leads to the development of resistance towards DNA damaging therapeutics. Objective: In this article, the focus is on targeting the key mediator of the DDR pathway, the ATM kinase. A new set of quinoline-3-carboxamides, as potential inhibitors of ATM, is reported. Methods: Quinoline-3-carboxamide derivatives were synthesized and cytotoxicity assay was performed to analyze the effect of molecules on different

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16

Draibe, Juliana, Ruth J. Pepper, and Alan D. Salama. "Treatment with Quinoline-3-carboxamide does not successfully prevent immune-mediated glomerulonephritis in mice." Nefrología 36, no. 6 (2016): 687–93. http://dx.doi.org/10.1016/j.nefro.2016.03.012.

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17

Draibe, Juliana, Ruth J. Pepper, and Alan D. Salama. "Treatment with Quinoline-3-carboxamide does not successfully prevent immune-mediated glomerulonephritis in mice." Nefrología (English Edition) 36, no. 6 (2016): 687–93. http://dx.doi.org/10.1016/j.nefroe.2016.08.004.

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18

Lehmann, D., D. M. Karussis, D. Fluresco, et al. "Immunomodulation of EAE by quinoline-3-carboxamide (linomide) inhibits the process of antigen presentation." Journal of Neuroimmunology 54, no. 1-2 (1994): 176. http://dx.doi.org/10.1016/0165-5728(94)90404-9.

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19

Khalifa, Nagy M., Ahmed M. Naglah, Mohamed A. Al-Omar, Mohamed H. Abo-Ghalia, and Abd El-Galil E. Amr. "Synthesis and Reactions of New Chiral Linear Carboxamides with an Incorporated Peptide Linkage Using Nalidixic Acid and Amino Acids as Starting Materials." Zeitschrift für Naturforschung B 69, no. 3 (2014): 351–61. http://dx.doi.org/10.5560/znb.2014-3282.

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4bA series of chiral linear carboxamide derivatives (2- 15) with an incorporated peptide linkage have been prepared via the coupling of 1-ethyl-1,4-dihydro-7-methyl-4-oxo-quinoline-3-carboxylic acid (nalidixic acid, 1) with appropriate amino acid methyl esters. Coupling of 1 with amino acid methyl esters gave the corresponding peptide methyl esters 2, which were hydrolyzed with methanolic sodium hydroxide to the corresponding acids 3. Hydrazinolysis of esters 2with hydrazine hydrate afforded the corresponding acid hydrazide derivatives 4. The latter compounds were coupled with appropriate alde

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20

Karussis, D. M., D. Lehmann, S. Slavin, et al. "Treatment of chronic-relapsing experimental autoimmune encephalomyelitis with the synthetic immunomodulator linomide (quinoline-3-carboxamide)." Proceedings of the National Academy of Sciences 90, no. 14 (1993): 6400–6404. http://dx.doi.org/10.1073/pnas.90.14.6400.

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21

Polo-Cuadrado, Efraín, Karoll Ferrer, Edison Osorio, Iván Brito, Jonathan Cisterna, and Margarita Gutiérrez. "Crystal structure, Hirshfeld surface analysis and DFT studies of N-(4-acetylphenyl)quinoline-3-carboxamide." Journal of Molecular Structure 1246 (December 2021): 131162. http://dx.doi.org/10.1016/j.molstruc.2021.131162.

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22

Schulze-Topphoff, Ulf, Aparna Shetty, Michel Varrin-Doyer, et al. "Laquinimod, a Quinoline-3-Carboxamide, Induces Type II Myeloid Cells That Modulate Central Nervous System Autoimmunity." PLoS ONE 7, no. 3 (2012): e33797. http://dx.doi.org/10.1371/journal.pone.0033797.

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23

He, Jun-Feng, Liu-Hong Yun, Ri-Fang Yang, et al. "Design, synthesis, and biological evaluation of novel 4-hydro-quinoline-3-carboxamide derivatives as an immunomodulator." Bioorganic & Medicinal Chemistry Letters 15, no. 12 (2005): 2980–85. http://dx.doi.org/10.1016/j.bmcl.2005.04.040.

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24

Carlsten, Hans, Charlotte Jonsson, Maria Bokarewa, Lena Svensson, and Andrej Tarkowski. "The impact of a new immunomodulator oxo-quinoline-3-carboxamide on the progression of experimental lupus." International Immunopharmacology 4, no. 12 (2004): 1515–23. http://dx.doi.org/10.1016/j.intimp.2004.07.009.

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25

Saudi, Manal N. S., Sherif A. F. Rostom, Hesham T. Y. Fahmy, and Ibrahim M. El Ashmawy. "Synthesis of 2-(4-Biphenylyl)quinoline-4-carboxylate and Carboxamide Analogs. New Human Neurokinin-3 (hNK-3) Receptor Antagonists." Archiv der Pharmazie 336, no. 3 (2003): 165–74. http://dx.doi.org/10.1002/ardp.200390016.

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26

Fransén Pettersson, Nina, Adnan Deronic, Julia Nilsson, et al. "The immunomodulatory quinoline-3-carboxamide paquinimod reverses established fibrosis in a novel mouse model for liver fibrosis." PLOS ONE 13, no. 9 (2018): e0203228. http://dx.doi.org/10.1371/journal.pone.0203228.

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27

Stenström, Martin, Per Anderson, Lena Eroukhmanoff, Tomas Leanderson, and Fredrik Ivars. "Selective depletion of splenic CD4 dendritic cells in mice treated with immunomodulatory quinoline-3-carboxamide ABR-215757." International Immunopharmacology 10, no. 8 (2010): 837–42. http://dx.doi.org/10.1016/j.intimp.2010.04.011.

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28

Ravi, Srimadhavi, Bhanu Priya, Pankaj Dubey, Vijay Thiruvenkatam, and Sivapriya Kirubakaran. "Molecular Docking and Molecular Dynamics Simulation Studies of Quinoline-3-Carboxamide Derivatives with DDR Kinases–Selectivity Studies towards ATM Kinase." Chemistry 3, no. 2 (2021): 511–24. http://dx.doi.org/10.3390/chemistry3020036.

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Quinoline-3-carboxamides are an essential class of drug-like small molecules that are known to inhibit the phosphatidylinositol 3-kinase-related kinases (PIKK) family kinases. The quinoline nitrogen is shown to bind to the hinge region of the kinases, making them competitive inhibitors of adenosine triphosphate (ATP). We have previously designed and synthesized quinoline-3-carboxamides as potential ataxia telangiectasia mutated (ATM) kinase inhibitors to function as an adjuvant treatment with DNA damaging agents. This article discusses the molecular docking studies performed with these derivat

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29

Idrees, M., Y. G. Bodkhe, N. J. Siddiqui, and S. S. Kola. "Synthesis, Characterization and in vitro Antimicrobial Screening of Some Novel Series of 2-Azetidinone Derivatives Integrated with Quinoline, Pyrazole and Benzofuran Moieties." Asian Journal of Chemistry 32, no. 4 (2020): 896–900. http://dx.doi.org/10.14233/ajchem.2020.22490.

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A series of 5-(benzofuran-2-yl)-N-(3-chloro-4-(2-(p-tolyloxy) substituted quinolin-3-yl)-2-oxoazetidin-1-yl)-1-phenyl-1H-pyrazole-3-carboxamide derivatives (4a-f) were synthesized with excellent yields by cyclocondensation reaction of 5-(benzofuran-2-yl)-N′-(2-(p-tolyloxy) substituted quinolin-3-yl)methylene)-1-phenyl-1H-pyrazole-3-carbohydrazide (3a-f) with chloroacetyl chloride in presence of triethylamine in DMF. One pot condensation of 5-(benzofuran-2-yl)-1-phenyl-1H-pyrazole-3-carbohydrazide (1) with 2-(p-tolyloxy) substituted quinoline-3-carbaldehyde (2a-f) in ethanol solvent in presence

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30

Jennbacken, Karin, Karin Welén, Anders Olsson, et al. "Inhibition of metastasis in a castration resistant prostate cancer model by the quinoline-3-carboxamide tasquinimod (ABR-215050)." Prostate 72, no. 8 (2011): 913–24. http://dx.doi.org/10.1002/pros.21495.

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31

Deronic, Adnan, Sofia Helmersson, Tomas Leanderson, and Fredrik Ivars. "The quinoline-3-carboxamide paquinimod (ABR-215757) reduces leukocyte recruitment during sterile inflammation: Leukocyte- and context-specific effects." International Immunopharmacology 18, no. 2 (2014): 290–97. http://dx.doi.org/10.1016/j.intimp.2013.12.008.

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32

Karussis, D., Z. Memer, D. Lehmann, et al. "Immunomodulation of experimental autoimmune encephalo-myelitis (EAE and CR-EAE) and of multiple sclerosis with quinoline-3-carboxamide." Journal of Neuroimmunology 56-63 (1995): 15. http://dx.doi.org/10.1016/0165-5728(95)98899-m.

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33

Yan, Ling, Per Bjork, Radu Butuc, et al. "Beneficial effects of quinoline-3-carboxamide (ABR-215757) on atherosclerotic plaque morphology in S100A12 transgenic ApoE null mice." Atherosclerosis 228, no. 1 (2013): 69–79. http://dx.doi.org/10.1016/j.atherosclerosis.2013.02.023.

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34

Stålhandske, T., A.-H. Jansson, R. Karlström, A. Maksimova, U. Wigow, and T. Kalland. "Restoration of suppressed immune response with the immune modulator quinoline-3-carboxamide (LS 2616) during experimental trypanosomas infection." International Journal of Immunopharmacology 7, no. 3 (1985): 391. http://dx.doi.org/10.1016/0192-0561(85)90421-7.

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35

Setälä, N., M. Röyttä, A. A. Salmi, and J. P. Erälinna. "3-31-21 Combination therapy with quinoline-3-carboxamide and tirilazad mesylate is effective in the treatment of experimental allergic encephalomyelitis (EAE)." Journal of the Neurological Sciences 150 (September 1997): S187. http://dx.doi.org/10.1016/s0022-510x(97)85780-2.

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36

Slavin, Shimon, Lola Weiss, Xia Wenlang, and David J. Gross. "Successful Treatment of Diabetes in Nod Mice with Advanced Disease by Islet Isografts following Immunoregulation with Linomide (Quinoline-3-Carboxamide)." Cell Transplantation 5, no. 6 (1996): 627–30. http://dx.doi.org/10.1177/096368979600500605.

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We have recently documented that oral Linomide (quinoline-3-carboxamide) prevents autoimmune insulitis, islet destruction, and diabetes in NOD mice treated at an early stage (5 wk of age) of the disease. In this report, we show that treatment of female NOD mice with advanced disease (age 23-24 wk) by syngeneic islet transplantation and oral Linomide administration results in prevention of graft insulitis and diabetes in the Linomide group up to 40 wk (diabetes at 40 wk: isograft recipients with Linomide n = 0 of 6; isograft recipients alone n = 5 of 6; p < 0.0001). The extent of protection

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37

Slavin, S. "Successful treatment of diabetes in nod mice with advanced disease by islet isografts following immunoregulation with Linomide (quinoline-3-carboxamide)." Cell Transplantation 5, no. 6 (1996): 627–30. http://dx.doi.org/10.1016/s0963-6897(96)00085-1.

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38

Li, Sai, Rui Jiang, Mingze Qin, Haicheng Liu, Guangyan Zhang, and Ping Gong. "Synthesis and Antitumor Activity of Novel 4-(2-Fluorophenoxy)quinoline Derivatives Bearing the 4-Oxo-1,4-dihydroquinoline-3-carboxamide Moiety." Archiv der Pharmazie 346, no. 7 (2013): 521–33. http://dx.doi.org/10.1002/ardp.201300029.

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39

Isaacs, John T., Roberto Pili, David Z. Qian, et al. "Identification of ABR-215050 as lead second generation quinoline-3-carboxamide anti-angiogenic agent for the treatment of prostate cancer." Prostate 66, no. 16 (2006): 1768–78. http://dx.doi.org/10.1002/pros.20509.

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40

Olsson, Anders, Anders Björk, Johan Vallon-Christersson, John T. Isaacs, and Tomas Leanderson. "Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumors." Molecular Cancer 9, no. 1 (2010): 107. http://dx.doi.org/10.1186/1476-4598-9-107.

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41

Cati, Dilovan S., and Helen Stoeckli-Evans. "The crystal structures of the ligand N-(quinolin-8-yl)pyrazine-2-carboxamide and of a tetranuclear copper(II) complex." Acta Crystallographica Section E Crystallographic Communications 75, no. 6 (2019): 755–61. http://dx.doi.org/10.1107/s2056989019005450.

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The title tridentate ligand, C14H10N4O, N-(quinolin-8-yl)pyrazine-2-carboxamide (HL1), crystallizes with three independent molecules (A, B and C) in the asymmetric unit. All three molecules are relatively planar (r.m.s. deviations are 0.068, 0.055 and 0.06 Å, respectively), with the NH H atom forming three-centered (bifurcated) intramolecular N—H...N hydrogen bonds in each molecule. There is also an intramolecular C—H...O contact present in each molecule, involving the benzene ring of the quinoline unit and the amide carboxamide O atom. In the crystal, the three molecules stack in columns with

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42

Oien, Nancee L., Roger J. Brideau, Todd A. Hopkins, et al. "Broad-Spectrum Antiherpes Activities of 4-Hydroxyquinoline Carboxamides, a Novel Class of Herpesvirus Polymerase Inhibitors." Antimicrobial Agents and Chemotherapy 46, no. 3 (2002): 724–30. http://dx.doi.org/10.1128/aac.46.3.724-730.2002.

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ABSTRACT Through broad screening of the compound library at Pharmacia, a naphthalene carboxamide was identified as a nonnucleoside inhibitor of human cytomegalovirus (HCMV) polymerase. Structure-activity relationship studies demonstrated that a quinoline ring could be substituted for naphthalene, resulting in the discovery of a 4-hydroxyquinoline-3-carboxamide (4-HQC) class of antiviral agents with unique biological properties. In vitro assays with the 4-HQCs have demonstrated potent inhibition of HCMV, herpes simplex virus type 1 (HSV-1), and varicella-zoster virus (VZV) polymerases but no in

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43

Billström, A., B. Kinnby, I. Lecander, and B. Åstedt. "Production of plasminogen activator inhibitor type-2 in human peripheral blood monocytes upregulated in vitro by the quinoline-3-carboxamide, Linomide." Fibrinolysis 10, no. 5-6 (1996): 277–83. http://dx.doi.org/10.1016/s0268-9499(96)80008-7.

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44

Li, Sai, Yanfang Zhao, Kewen Wang, et al. "Discovery of novel 4-(2-fluorophenoxy)quinoline derivatives bearing 4-oxo-1,4-dihydrocinnoline-3-carboxamide moiety as c-Met kinase inhibitors." Bioorganic & Medicinal Chemistry 21, no. 11 (2013): 2843–55. http://dx.doi.org/10.1016/j.bmc.2013.04.013.

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45

Hu, Baihua, Ron Bernotas, Rayomand Unwalla та ін. "Quinoline-3-carboxamide containing sulfones as liver X receptor (LXR) agonists with binding selectivity for LXRβ and low blood–brain penetration". Bioorganic & Medicinal Chemistry Letters 20, № 2 (2010): 689–93. http://dx.doi.org/10.1016/j.bmcl.2009.11.062.

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46

Ma, Baojun, Hao Xie, Jie Li, Haijuan Zhan, Keying Lin, and Wanyi Liu. "Bifunctional solid acid photocatalyst TiO 2 /AC/SO 3 H with high acid density for pure green photosynthesis of 2-quinoline carboxamide." Journal of Molecular Catalysis A: Chemical 420 (August 2016): 290–93. http://dx.doi.org/10.1016/j.molcata.2016.04.031.

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47

Li, Sai, Rui Jiang, Mingze Qin, Haicheng Liu, Guangyan Zhang, and Ping Gong. "ChemInform Abstract: Synthesis and Antitumor Activity of Novel 4-(2-Fluorophenoxy)quinoline Derivatives Bearing the 4-Oxo-1,4-dihydroquinoline-3-carboxamide Moiety." ChemInform 44, no. 45 (2013): no. http://dx.doi.org/10.1002/chin.201345198.

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48

Mohammadnezhad, Gholamhossein, Neda Ahfad, Soraya Meghdadi, et al. "Dinuclear Nickel(II) and Copper(II) Complexes of 8‐Quinoline‐1 H ‐pyrazole‐3‐carboxamide: Crystal Structure, Magnetic Properties, and DFT Calculations." European Journal of Inorganic Chemistry 2021, no. 18 (2021): 1786–95. http://dx.doi.org/10.1002/ejic.202100142.

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Furlotti, Guido, Maria Alessandra Alisi, Claudia Apicella, et al. "Discovery and Pharmacological Profile of New 1H-Indazole-3-carboxamide and 2H-Pyrrolo[3,4-c]quinoline Derivatives as Selective Serotonin 4 Receptor Ligands." Journal of Medicinal Chemistry 55, no. 22 (2012): 9446–66. http://dx.doi.org/10.1021/jm300573d.

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Pathuri, Gopal, Qian Li, Altaf Mohammed, Hariprasad Gali, J. Thomas Pento, and Chinthalapally V. Rao. "Synthesis and in vivo evaluation of N-ethylamino-2-oxo-1,2-dihydro-quinoline-3-carboxamide for inhibition of intestinal tumorigenesis in APCMin/+ mice." Bioorganic & Medicinal Chemistry Letters 24, no. 5 (2014): 1380–82. http://dx.doi.org/10.1016/j.bmcl.2014.01.042.

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