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Dissertations / Theses on the topic 'Quinoline derivative'

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Published: 4 June 2021
Last updated: 26 July 2025

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1

Ding, Ying. "Gap junction enhancer as an anti-cancer agent via GJIC-independent and -dependent pathways." Diss., Kansas State University, 2013. http://hdl.handle.net/2097/15705.

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Doctor of Philosophy<br>Department of Biochemistry and Molecular Biophysics<br>Thu Annelise Nguyen<br>Gap junctions (GJ) are intercellular channels connecting adjacent cells, allowing small molecules to transport between cells, thereby maintaining all homeostasis. Loss of gap junctional intercellular communication (GJIC) and/or connexins, the gap junction proteins, is a hallmark of cancer. Restoration of GJIC and/or increase of connexin expression have been related to the reduction of tumorigenesis. Connexins have been reported as tumor suppressors due to both GJIC-independent and -dependent m
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2

Taylor, David Lawrence. "The Reverse Vilsmeier route to quinolinium salts and derivatives." Thesis, University of Sunderland, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294163.

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3

Haddad, Jalal. "Synthesis and chemistry of some quinoline-5,8-diones." Virtual Press, 1994. http://liblink.bsu.edu/uhtbin/catkey/917048.

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The synthesis of several 7-substituted analogs of 2-methylquinoline-5,8-dione and their chemistry are described. In this investigation the following compounds were prepared.5,7-Diformamido-8-hydroxy-2-methylquinoline (207), 7-formamido-2methylquinoline-5,8-dione (199), 7-acetamido-2-methylquinoline-5,8-dione (6), 7-isobutyramido-2-methylquinoline-5,8-dione (200), 7-amino-2-methylquinoline-5,8-dione (210), 7-amino-6-chloro-2-methylquinoline-5,8-dione (213), 7-methoxy-2-methylquinoline5,8-dione (214), 7-ethoxy-2-methylquinoline-5,8-dione (215), 7-isopropyloxy-2methylquinoline-5,8-dione (216), 7-
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4

Klaas, Phindile Jonathan. "Novel approaches to the synthesis of quinoline derivatives." Thesis, Rhodes University, 2001. http://hdl.handle.net/10962/d1004751.

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The investigation has been concerned with the application of the Baylis-Hillman methodology to the synthesis of quinoline derivatives. An extensive range of novel Baylis-Hillman products has been prepared, typically in moderate to excellent yields, by condensing 2-nitrobenzaldehyde derivatives with various vinyl ketones and acrylic esters in the presence of diazabicyclo[2.2.2]octane (DABCO). Reduction of the nitro group in the Baylis-Hillman products was effected by catalytic hydrogenation in ethanol using a 10% palladium-on-carbon catalyst to afford quinoline, quinoline-N-oxide and quinolone
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5

Pakade, Vusumzi Emmanuel. "Application of the Baylis-Hillman reaction in the preparation of quinoline derivatives." Thesis, Rhodes University, 2006. http://hdl.handle.net/10962/d1007669.

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The reaction of various 2-nitrobenzaldehyde derivatives with methyl vinyl ketone (MVK) in the presence of 1,4-diazabicyclo[2.2.2]octane (DABCO) has afforded the Baylis-Hillman adducts in moderate to good yield. Dissolution of the catalyst in the solvent before the addition of the aldehyde was observed to improve the yield. Reduction of the Baylis-Hillman adducts was effected by catalytic hydrogenation using a 10% palladium-on- carbon catalyst in ethanol to give quinoline and quinoline-N-oxide derivatives and, in some cases, acyclic reduction products. All products were characterised using NMR
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6

Loke, P. L. "Chemoenzymatic and chemical synthesis of enantiopure quinoline derivatives and alkaloids." Thesis, Queen's University Belfast, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273295.

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7

Sharma, A. K. "Studies towards antitumor quinoline derivatives and development of useful synthetic methodologies." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2001. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2319.

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8

Kgokong, Joseph Lebese. "Trifluoromethyl-substituted quinoline and tetrazole derivatives :design, synthesis, antimalarial activity and cytotoxicity / Joseph L. Kgokong." Thesis, North-West University, 2008. http://hdl.handle.net/10394/3732.

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Malaria is a complex parasitic disease caused by the Plasmodium falciparum. It has been found to be responsible for the death of many people particularly in under-developed and developing countries. For many years chloroquine and quinine have been the mainstay of therapy for this disease. The research on new therapies against malaria have been hampered by factors such as the development of resistance against these and some of the new drugs or combinations thereof, the lack of adequate knowledge on the exact causes and mechanisms of resistance to the drugs and their mode of action, together wit
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9

Tukulula, Matshawandile. "The design and synthesis of novel HIV-1 protease inhibitors." Thesis, Rhodes University, 2009. http://eprints.ru.ac.za/1563/.

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10

Lee, Yi-Chen. "Studies towards the development of novel HIV-1 integrase inhibitors." Thesis, Rhodes University, 2010. http://hdl.handle.net/10962/d1005022.

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The project has focused on the preparation of several series of compounds designed as potential HIV-1 integrase inhibitors. Various 2-nitrobenzaldehydes have been reacted with two activated alkenes, methyl vinyl ketone (MVK) and methyl acrylate, under Baylis-Hillman conditions to afford α-methylene-β-hydroxylalkyl derivatives in moderate to excellent yields. The reactions were conducted using the tertiary amine catalysts, 1,4-diazabicyclo[2.2.2]octane(DABCO) or 3-hydroxyquinuclidine (3-HQ) with chloroform as solvent, and yields were optimised by varying the catalyst, reagent concentrations and
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11

Gadakh, S. K. "Enantioselective synthesis of bioactive molecules and development of synthetic methodologies involving formation of quinoline and coumarin derivatives via Rh-catalyzed ortho C-H bond activation of aromatics." Thesis(Ph.D.), CSIR-National Chemical Laboratory, 2015. https://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/5939.

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Enantioselective Synthesis of Bioactive Molecules and Development of Synthetic Methodologies Involving Formation of Quinoline and Coumarin Derivatives via Rh-Catalyzed ortho C-H Bond Activation of Aromatics Research Student: Sunita K. Gadakh AcSIR Roll: 10CC11J26017 Research Guide: Dr. A. Sudalai The thesis entitled “Enantioselective Synthesis of Bioactive Molecules and Development of Synthetic Methodologies Involving Formation of Quinoline and Coumarin Derivatives via Rh-Catalyzed ortho C-H Bond Activation of Aromatics’’ is divided into four chapters. The title of the thesis clearly refle
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12

Leung, Suet Ching. "New and established drug targets for malaria chemotherapy from lead optimisation of 2-pyridyl quinolone PfNDH2 inhibitors to semi-synthetic pyrrole Mannich base artemisinin derivatives." Thesis, University of Liverpool, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.577488.

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The rapid development of resistance to currently deployed antimalarial drugs has raised the desperate need for new chemotherapies, preferably with novel therapeutic target. This thesis explores the synthesis of novel quinolone compounds and artemisinin derivatives targeting the mitochondrial electron transfer chain (ETC) and the haemoglobin degradation of Plasmodium falciparum respectively. The respiratory chain of the human malaria is an attractive target for antimalarial drugs. It is believed that the collapse of the mitochondrial potential will shut down the metabolism and malaria parasite
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13

Benaissa, Tahar. "Synthèse de ligands contenant un atome de fluor et pouvant donner des complexes à applications médicales : étude de la complexation de la 5-fluoro-8-hydroxyquinoline avec des cations métalliques, par RMN du fluor." Université Joseph Fourier (Grenoble), 1996. http://www.theses.fr/1996GRE10100.

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Ce travail se place a la convergence de deux grands themes etudies au laboratoire: le marquage de molecules par un atome de fluor et l'etude de la complexation de cations metalliques par des ligands. La premiere partie concerne la preparation de deux series de ligands contenant du fluor: des biphenols et des composes contenant des groupements 2-fluoropyridines. Les biphenols substitues par deux ou quatre atomes de fluor (en position 4,4' ; 5,5' ; 4,4 ;,5,5') ont ete obtenus a partir de bromophenols par une reaction de type ullman. Leurs derives sulfones ont egalement ete prepares pour augmente
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14

Xu, Dawen [Verfasser], Fritz E. [Akademischer Betreuer] Kühn, Fritz E. [Gutachter] Kühn та Lukas [Gutachter] Hintermann. "Intramolecular α-alkylation and α-alkenylation of coumarin and quinolinone derivatives / Dawen Xu ; Gutachter: Fritz E. Kühn, Lukas Hintermann ; Betreuer: Fritz E. Kühn". München : Universitätsbibliothek der TU München, 2019. http://d-nb.info/1192911644/34.

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15

Bakhouya, Abderrahmane. "Etude du processus de libération des principes actifs à partir de formes galéniques lipidiques à matrice de gélucire : modélisation de la pénétration tissulaire de la ciprofloxacine." Saint-Etienne, 1996. http://www.theses.fr/1996STET4013.

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Les formes galéniques matricielles, à matrice lipidique tels que les gélucires, permettent une libération contrôlée du principe actif. Ces matrices peuvent subir une érosion plus ou moins prononcée selon la nature de l'excipient. Lorsque le gélucire est hydrophile, le processus de libération s'effectue par érosion de la forme galénique. Avec un gélucire lipophile, le processus de libération est contrôlé par diffusion. Pour simuler le contrôle de la libération par érosion dans l'organisme, nous avons construit un modèle numérique qui tient compte de tous les facteurs ; notamment, les trois stad
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16

Martins, Sandra Cristina Cardoso. "The anticancer potential of CITme, a quinoline derivative." Diss., 2011. http://hdl.handle.net/2263/26129.

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3-[3-(7-chloro-quinolin-4-yl amino) phenyl]-1-(4-methoxy-phenyl) prop-2-enone citrate “CITme” is a substituted quinoline derivative, synthesized as a potential antitumour agent. The aim of this study was to investigate CITme with regard to antitumour activity, toxicity and pharmacokinetics. In vitro screening for neoplastic cytotoxic effects using standard cell culture techniques revealed cytotoxic activity against HeLa, DU-145, MCF-7, Jurkat and CoLo 320 human derived cancer cell lines at low concentrations. Toxicity was significantly less in either normal resting and stimulated lymphocytes o
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17

Chang, Chih-Kai, and 張智凱. "The pharmacokinetics of furo[3,2-c]quinoline derivative, a new synthetic antitumor drug of amsacrine analogs." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/61216869672731019440.

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碩士<br>高雄醫學大學<br>藥學研究所碩士班<br>92<br>Amsacrine is an antitumor drug against acute adult leukemia and lymphoma. The two model drugs, PK-A2 and PK-A3, are new antitumor compounds and synthesized from the substitution and modification of the main chemical structure of amsacrine. So far, there is no data to describe the pharmacokinetic characters of the two model drugs. In this study, drugs were administered by IV bolus into Wistar rats weighted 190 to 220 g. The blood samples were extracted with dichlomethane and then analyzed by HPLC method. Finally, we discussed the individual pharmacokinetic char
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18

Chang, Kuo-Feng, and 張國峰. "The novel quinoline-derivative BPIQ with anti-proliferation and anti-migration properties in human lung cancer cells." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/28068296182785224870.

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碩士<br>高雄醫學大學<br>生物科技學系碩士班<br>99<br>2,9-bis(2-(pyrrolidin-1-yl)ethoxy)-6-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-11H-indeno[1,2-c]quinolin-11-one (BPIQ) is a derivative of 6-arylindeno[1,2-c]quinoline, which exhibits anti-cancer effects. In our study, BPIQ efficiently inhibited cell proliferation of human lung cancer cells. Furthermore, BPIQ reduced the levels of cell cycle-associated proteins, such as cyclin A, cyclin B and CDK1, and subsequently arrested DNA replication. As a result, the arrest of G2/M phase by BPIQ was observed. Moreover, the up-regulation of pro-apoptotic Bad, Bim and down-re
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19

Chou, Hua-Cheng, and 周華晟. "Designed to Synthetic Benzyl Ether-Linked Glucuronide Derivative of Benzo[de]quinoline camptothecin(BQC) for Selective Anticancer Therapy." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/17913684817324924372.

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碩士<br>嘉南藥理科技大學<br>藥學系<br>101<br>5, 6-Dihydro-4H-benzo[de]quinolone camptothecin (BQC), a derivative of camptothecin, has been identified as a potential anti-tumor drug. Additionally, BQC could be conjugated with a methyl glucuronate to improve its tumor specificity and also its water solubility. Dr. Masamichi. firstly synthesized compound 6 from compound 1 through nitrification, oxidation and reduction. Compound 6 then was conjugated with compound 7 to give BQC. However, when the start material is compound 1, the nitrification step would produce a 6-nitro and 6, 8-dinitro byproduct, thus it re
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20

Chen, Yi-Pei, and 陳羿霈. "A Novel Quinoline Derivative Induced Intrinsic Apoptotic Pathway and Intra-S Phase Arrest in Docetaxel-Resistant Prostate Cancer Cell." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/37413220049484433257.

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碩士<br>高雄醫學大學<br>香粧品學系碩士班<br>105<br>In this study, BV001 is a new synthetic quinoline derivative with the cytotoxic effects in prostate cancer(PCa) cells. BV001 has been found to have the anti-proliferation in PCa cell lines(PC3 and PC/DX25) by arresting cell cycle in intra-S phase. Nowadays, the docetaxel-base therapies are used as a first-line chemotherapy for castration-resistant prostate cancer(CRPC) patients. However, almost all patients died from docetaxel-resistant CRPC during three to five months. Hence, the development of effective chemotherapeutic agents for CRPC patients has become i
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21

Hlungwani, Isaac. "Design, synthesis and biological evaluation of novel tetrasubstituted quinoline-3-carboxamides derivatives." Diss., 2020. http://hdl.handle.net/11602/1558.

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MSc (Chemistry)<br>Department of Chemistry<br>Quinolines are well known naturally occurring heterocyclic compounds with nitrogen as a heteroatom. Quinolines are also one of the major classes of naturally occurring compounds and the interest in their chemistry is due to the wide range of their biological activities. The objective of the project was the synthesis of novel tetra-substituted quinoline-3carboxamides and subsequent transformation to other novel derivatives and evaluation of their biological activities against malaria and cytotoxicity. In achieving the objective, 2-chloroquinoline-
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22

KO, DEN-YUAN, and 柯登淵. "Synthesis of Quinoline Derivatives of Curcumin." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/02939843223114971684.

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碩士<br>中國文化大學<br>化學系應用化學碩士班<br>104<br>Curcumin is isolated from the rhizome of Curcuma longa. Much evidence indicated that curcumin could be used as a therapeutic agent in the treatment of Alzheimer’s disease (AD) and could reduce the symptoms, including oxidative damage, inflammation, senile plaques, neurofibrillary tangles, cell cycle dysregulation and neuron damages. AD, a complex disease with multiple etiological factors, needs a multifunctional drug forits treatment. Curcumin is one of the potential drugs in the treatment of AD. Some quinolines are known as good metal chelating agents
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23

Teitgen, Alicen M. "Novel synthesis of quinoline-5,8-dione analogues." 2012. http://liblink.bsu.edu/uhtbin/catkey/1678996.

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The chemistry of quinonline-5,8-dione as a functional group is a developing field because of its various biological aspects. Lavendamycin and streptonigrin are known antibiotic, antitumor agents containing the quinolone-5,8-dione functional group believed to provide their antitumor properties. Most cancer cells show an elevated level of NQO1 enzyme which activates lavendamycin to act as an antitumor agent. The research goal is to explore different synthetic methods and reactions to produce novel quinolone-5,8-dione analogues with unique structural features while keeping the selective cytotoxic
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24

Lin, Bao-Jiun, and 林保君. "Synthesis and Biological Evaluation of Furo[3,2-h]quinoline and Furo[2,3-h]quinoline Derivatives." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/61262624727227638045.

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碩士<br>大仁科技大學<br>製藥科技研究所<br>97<br>Certain aniline- or phenoxy-substituted furo[3,2-h]quinolin-8-yl, furo[2,3-h]quinolin-2-yl, and 7-prop-2-ynyloxyquinolin-2-yl derivatives were synthesized and evaluated for their anti-inflammatory activities. These compounds were synthesized via alkylation of hydroxyl precursors followed by the chlorination, cyclization, and reaction with appropriate Ar-NH2 or Ar-OH. Anti- inflammatory activities of these quinoline derivatives were evaluated on the suppression of reactive oxygen species (ROS) production induced by formyl-methionyl-leucyl-phenylalanine (fMLP, 1
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25

Chen, Ping-Cheng, and 陳柄成. "Synthesis of 2-Phenyl-4-Quinolone Derivatives." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/87206938834357809645.

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碩士<br>國立成功大學<br>化學系碩博士班<br>97<br>Compounds isolated from natural products containing a heterocyclic ring represent an important class of biologically active molecules that are widespread in nature. Organic chemists have reported many methods for the total synthesis of these compounds. In our laboratory, we are interested in the synthesis of 2-phenyl-4-quinolone derivatives due to their anticancer activity. On the other hand, these derivatives showed the poor solubility in water and organic solvent. In order to solve this problem, we designed to synthesize these derivatives by Mannich reaction
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26

Lo, Wei Fen, and 羅偉棻. "Synthesis and anticancer evaluation of 4-anilinofuro[2,3-b]quinoline and 4-anilinofuro[3,2-c]quinoline derivatives." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/fyfqj3.

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博士<br>高雄醫學大學<br>醫藥暨應用化學系博士班<br>103<br>Certain furo[2,3-b]quinoline and furo[3,2-c]quinoline derivatives have been synthesized and evaluated for their antiproliferative activities. Among them, CIL-102 was found to be the most potent. However, it exhibited general cytotoxicity to most of cancers and normal cells. In addition, it displayed other drawbacks such as low oral availability and poor aqueous solubility. In order to improve these drawbacks, we optimized the chemical structure of CIL-102 to settle these problems. CIL-102 is active against the growth of PC-3、A549, MCF-7 and M-10 cells with
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27

Hung, Chia, and 蒲家弘. "1-Arylpyrrolo[3,2-c]quinoline Derivatives as Potential Anticancer Agents." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/24584162853152668729.

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碩士<br>靜宜大學<br>應用化學研究所<br>99<br>This thesis is aimed at design and synthesis of 1-arylpyrrolo[3,2-c]quinoline derivatives as potential anticancer agents. We had been using quinoline ring as skeleton for the design of 1-arylpyrrolo[3,2-c]quinoline derivatives to force the two aromatic rings in cis conformations. Results of in vitro cytotoxicity presumed that this series of compounds have potentials as anticancer drugs. In this study, we change substituent on aryl ring to prepare a series new 1-arylpyrrolo[3,2-c]quinoline derivatives. The synthesis was initiated from the condensation of appropria
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28

Yang, Chiao-Li, and 楊巧麗. "Synthesis and Biological Evaluation of Benzofuro[2,3-b]quinoline Derivatives." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/46052568130848169814.

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博士<br>高雄醫學大學<br>藥學研究所<br>98<br>Planar polyfused heteroaromatic compounds have various biological activities such as anticancer, antibacterial and antiviral effects. A series of 11-alkoxylated and 11-aminated benzofuro[2,3-b]quinoline derivatives were designed, synthesized, and evaluated for their anti-TB and cytotoxic activities. The known 11-chlorobenzofuro[2,3-b]quinoline (62) was synthesized in situ from anthranilic acid and 2-coumaranone in phosphorus oxychloride in 51% yield for the first time. Treatment of 62 with alcohols and amines gave 11-alkoxylated and 11-aminated benzofuro[2,3-b]q
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29

Lin, Ming-Nan, and 林明楠. "Synthesis and Biological Evaluation of Indeno[1,2-b]quinoline Derivatives." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/11110602183432189459.

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碩士<br>高雄醫學大學<br>醫藥暨應用化學研究所<br>96<br>Synthesis and antiproliferative evaluation of 11H-indeno[1,2-b]quinoline derivatives with the structural characteristics of DNA intercalator are described. The results of this study indicate that the cytotoxic effect depends on the basic side chains that substituted in the planar nucleus of 11H-indeno[1,2-b]quinoline. Substituents at C-10 and C-11 positions are crucial to the antiproliferative potency of 11H-indeno[1,2-b]quinoline, the aminoalkoxyimino substitutent of10-methyl-11H-indeno[1,2-b]quinolin-11-one (8c-h), 11-oxo-11H-indeno[1,2-b]quinoline-10-carb
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Xie, You-Tern, and 謝宥騰. "Amberlyst 15-Promoted Improved Synthesis of Quinoline and Imide Derivatives." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/07304571302598657970.

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碩士<br>高雄醫學大學<br>藥學研究所<br>96<br>Amberlyst 15 is a solid acid of catalytic agent, by the advantage it is easy to isolate and remove, and have no volatility and corrosiveness. Amberlyst 15 can be to recycle and used again, and will not pollute the environment. Compared with metal Lewis acid catalyst being the environmental protection even more, and comparatively cheap too. 　Quinoline and its derivatives display a wide spectrum of biological activities such as antimalarial, antibacterial, antidiabetic, and anti-inflammatory. 　Imide derivatives constitute an important class of organic compounds wit
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31

Tseng, Chih-Hua, and 曾志華. "Synthesis and Biological Evaluation of Indeno[1,2-c]quinoline Derivatives." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/15724151089081379022.

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博士<br>高雄醫學大學<br>藥學研究所<br>96<br>Although the quinoline ring is found in a wide variety of biologically active compounds and is frequently condensed with various heterocycles, synthesis and biological evaluation of the indenoquinoline skeleton attracts only very limited attention. Synthesis of certain indeno[1,2-c]quinoline derivatives (formula I) wherein R1 represents hydrogen and halide; R2 represents hydrogen, halide, hydroxy, alkylamino, arylamino, cyclic alkylamino such as piperazine, morpholine and their substituted derivatives; R3 represents hydrogen, hydroxy, and alkylamino. R4 represent
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32

Wei, Yin-Ling, and 魏吟玲. "Design and Synthesis of Quinoline Derivatives as Potential Cytotoxic Agents." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/60126835714289198157.

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碩士<br>國立臺灣大學<br>藥學研究所<br>93<br>The aim of this thesis is to design and synthesize quinoline derivatives as potential cytotoxic agents. Two series of target compounds, 3-phenylquinolines (7-10) and 2-phenylquinolines (11-14, 17 and 18), were prepared and evaluated for their cytotoxicity. In the preparation of 3-phenylquinolines 7-10, the required intermediates 8-nitro-3-phenylquinoline (1a) and 3-(4-methoxyphenyl)-8-nitroquinoline (1b) were obtained from 8-nitroquinoline by bromination with N-bromosuccinimide (NBS) followed by Suzuki coupling reaction. Reduction of the nitro compounds 1a,b with
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33

Shu, Yi-Ling, and 徐宜伶. "1-Arylpyrrolo[3,2-c]quinoline Derivatives as Potential Anticancer Agents." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/69079911972583018314.

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碩士<br>靜宜大學<br>應用化學研究所<br>98<br>This thesis is aimed at design, synthesis, and evaluation of anticancer activity of 1-arylpyrrolo[3,2-c]quinoline derivatives. Combrestastatin A4 (CA-4) is a tubulin polymerization inhibitor, and its structural features possess two aryl rings containing methoxy groups in the cis form. Quinoline derivatives possess various biological activities in many aspects. It was used for the design of 1-arylpyrrolo[3,2-c]quinolines to force two aryl rings in cis form. In this study, we introduced substituents on the quinoline of 1-arylpyrrolo[3,2-c]quinoline derivatives. The
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34

Chen, Yu-Liang, and 陳昱良. "Synthesis and Biological Evaluation of Indolo[3,2-c]quinoline Derivatives." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/77952279380878195727.

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碩士<br>高雄醫學大學<br>醫藥暨應用化學研究所碩士班<br>95<br>Synthesis and antiproliferative evaluation of 11H-indolo[3,2-c]quinoline derivatives with the structural characteristics of DNA-intercalator are described. 11H-Indolo[3,2-c]quinoline is a coplanar tetracyclic heterocycle in which the consisting 2-phenyl- naphthalene are conformationally locked through a nitrogen bridge. The results of this study indicate that the cytotoxic effect depends on the basic side chains inserted in the planar nucleus of 11H-indolo[3,2-c]quinoline. The O-alkyloximes substituted of indoloquinoline derivatives(3e, 3f, 3g, 5c), which
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Wu, Jian-Long, та 吳建隆. "Ionic liquid promoted synthesis of α-azidoketones and quinoline derivatives". Thesis, 2007. http://ndltd.ncl.edu.tw/handle/16603925226947001269.

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碩士<br>高雄醫學大學<br>藥學研究所碩士班<br>95<br>Room temperature ionic liquids (RTIL) are liquids that are composed entirely of ions. In fact, ionic liquids can now be produced which remain liquid at room temperature and below (even as low as -90℃) and can be appeared to be undemanding and inexpensive to manufacture. Ionic liquids offer an attractive alterative to conventional organic liquids for clean synthesis, as they are recycling easily, lacking flammability, and possessing no vapour pressure effectively. Comparing with classical molecular solvents, the ionic liquids are environmentally benign reaction
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曹雪雄. "Synthesis and Application of Mono(Di)-Methine Quinoline Heterocyclic Derivatives." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/01104416602051339795.

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碩士<br>國立臺灣科技大學<br>纖維及高分子工程技術研究所<br>85<br>In this study, Synthesis and application of Mono(Di)-methine quinoline heterocyclic derivatives. Quinoline was reacted with ethyl(amyl) iodide to give 1-substituted-2(4)-methyl quinoline, resulted in producing a series of Mono(Di)-methine and Aza- methine quinoline heterocyclic derivatives. In part one, quinoline was condensed with terephthalaldehyde to give a series of Di-methine quinoline derivatives, which leads to a series of violet to purplish blue coloured. In part two, quinoline was condensed with heterocyclic compounds of keton structur
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Jian, Zhenxing, and 簡振興. "1-Aryltriazolo[4,5-c]quinoline Derivatives As Potential Anticancer Agents." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/27734992176570584849.

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碩士<br>靜宜大學<br>應用化學系<br>100<br>This thesis is aimed at design and synthesis of 1-aryltriazolo[4,5-c]quinoline derivatives as potential anticancer agents. Combrestastatin A4 (CA-4) is a tubulin polymerization inhibitor, and quinoline derivatives are known to possess biological activities in many aspects. Thus, quinoline skeleton was chosen for the design of 1-aryltriazolo[3,2-c]quinoline derivatives to force the two aromatic rings in cis conformations as those in CA-4. Condensation of anthranilic acids with 2-nitroacetaldehyde oxime resulted in 2-(2-nitroethylideneamino)benzoic acid (2), which w
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Wu, Cheng-Hsin, and 吳政炘. "Synthesis of Indeno[1,2-c]quinoline Derivatives as Antituberculosis Agents." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/87358627783172486464.

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碩士<br>高雄醫學大學<br>醫藥暨應用化學研究所<br>100<br>The first-line drugs currently used for the treatment of tuberculosis (TB) infection are streptomycin, isoniazid (INH), ethambutol, pyrazinamide, and rifampicin. However, the current TB treatment regimens, although highly effective, are far from ideal. Recently, the emergence of multi-drug resistant (MDR) strains and the global human immunodeficiency virus (HIV) pandemic have created an urgent need for alternative drug treatments for Mycobacterium tuberculosis infection. Over the past few years, we have been particularly interested in the synthesis of conde
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Fang, Kuo-Chang, and 方國璋. "Synthesis, Antibacterial, and Cytotoxic Evaluation of Quinolone Derivatives." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/20909424944491902243.

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博士<br>高雄醫學大學<br>藥學研究所<br>89<br>Although the structure-activity relationships of antibacterial fluoroquinolones have been extensively investigated, the optimum substituent at C-7 position which has a great impact on potency, spectrum, solubility and pharmacokinetics has not been precisely defined. The present study describes the preparation and evaluation of certain norfloxacin derivatives with an additional functional moiety such as 4-hydroxyaminoalkyl (R-C=N-OH) on the C-7 piperazin-1-yl group, with the aim of providing extra hydrogen-bonding capabilities with the target DNA gyrase and theref
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Hsieh, Han-Jie, and 謝漢杰. "Selective Alkylation of Quinolin-2(1H)-one Derivatives." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/64890841320536430744.

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碩士<br>大仁科技大學<br>製藥科技研究所<br>96<br>As part of our ongoing studies aimed at the synthesis of oxime- and amide-containing quinolin -2(1H)-one derivatives, we selected 8-hydroxy quinolin-2(1H)-ones as a potential precursor. The synthesis requires twosuccessive alkylations. This first alkylation can be achieved selectively at phenolic OH to give 8-benzyloxyquinolin-2(1H)-one and 8-methoxy-quinolin -2(1H)-one, respectively. The second alkylation, however, involves anbident anion and can be expected to yield a mixture of N1- and / or O2-alkylated products. According to the literature, alkylation of 2-
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Bipath, Nirvashini. "Synthesis, spectroscopic properties and cytotoxicity of boron- dipyrromethene fluorescent dyes." Thesis, 2015. http://hdl.handle.net/10321/1172.

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Submitted in fulfilment of the requirements of the Degree of Master of Technology: Chemistry, Durban University of Technology. 2014.<br>In this study, we report the synthesis of three quinolone bearing imidazole derivatives 2, 3 and 4 and two quinolone bearing BODIPY dyes 5 and 7. In the synthesis of 2, 3 and 4, the first step was the preparation of the starting compound 2-chloro-3-formyl quinoline (1); the Vilsmeier-Haack cyclisation protocol was used. Compound 1 was used with the appropriate diamine, together with POCl3 to produce 2, 3 and 4. These compounds were characterized by IR, 1H-N
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Chung, Kuin-Yu, and 鍾昆宇. "Synthesis and Cytotoxic Evaluation of 6-Arylindeno[1,2-c]quinoline Derivatives." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/38733413069967985944.

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碩士<br>高雄醫學大學<br>醫藥暨應用化學研究所<br>97<br>This thesis describes the synthesis and cytotoxic evaluation of 6-arylindeno[1,2-c]quinoline derivatives. The synthesized compounds were evaluated for their antiproliferative activities against liver cancers including Hep 3B、Hep G2、Hep 2.2.1 cell lines and lung caners including A549、H1299 cell lines. The results of this study indicated that the introduction of fluoro group at C-2 position significantly enhanced antiproliferative potency. The introduction of basic side chains on the tetracyclic pharmacophore improved selectivity against cancer cells. For exam
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Li, Shu-Yu, and 黎淑雲. "Synthesis and Cytotoxic Evaluation of Certain Pyrido[3,2-g]quinoline Derivatives." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/29517969036062887881.

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博士<br>高雄醫學大學<br>藥學研究所博士班<br>95<br>The present report describes the synthesis and evaluation of tricyclic pyrido[3,2-g]quinoline derivatives in which an additional pyridine ring is linearly fused on the antibacterial quinoline-3-carboxylic acid. Among them, only both diethyl 4, 6- diamino -10- methylpyrido- [3,2-g]quinoline-3,7-dicarboxylate (9a) and diethyl 4,6-bis-(3-dimethyl- aminopropylamino) -10- methylpyrido[3,2-g]quinoline-3,7-dicarboxylate (9d) were able to inhibit cell proliferation of MCF-7 (Breast), NCI-H460 (Lung), and SF-268 (CNS) implying either amino or dimethylaminopropyl moiety
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Huang, Zun-Yuan, and 黃尊遠. "Synthesis and Biological Evaluationof 4-Anilinofuro[2,3-b]quinoline andStyrylquinoline Derivatives." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/58178540188559612818.

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碩士<br>高雄醫學大學<br>醫藥暨應用化學研究所碩士班<br>94<br>2-phenyl-4-quinolone derivatives have been found as anti-tumor agents and Lee etc found their to interacted with tubuline and caused mitotic arrest. We synthesized certain 2-phenyl-8-hydroxyquinoline derivatives to have potent proliferativty. Us analyse styrylquinoline have been reported to have various biological activities such as anti-HIV1. Therefore, we synthesized styrylquinoline derivatives and evaluted their anticancer activities. We found that Compounds 27,35 have potent proliferativty. The furoquinoline alkaloids isolated from the Rutaceac fa
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Chen, Yu-Wen, and 陳郁旻. "Synthesis and anticancer evaluation of 4-anilinofuro[2,3-b]quinoline derivatives." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/83540955128389734811.

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博士<br>高雄醫學大學<br>醫藥暨應用化學研究所<br>100<br>We have reported the preparation and anticancer evaluation of certain 4-anilinofuro-[2,3-b]quinolines. However, drawbacks such as lack of selective cytotoxicity, poor oral bioavailability, and poor water solubility exhibited by these compounds prompted us to search for newer derivatives. Among them, (E)-1-(4-(furo[2,3-b]quinolin-4-ylamino) phenyl)ethanone O-2-aminoethyloxime (17g) is selectively active against the growth of NCI-H460 and is highly water-soluble (63 μg/mL). Its hydrochloride salt, 17g．3 HCl exhibited not only excellent water solubility (1049
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Murali, Dheeptha. "Chemistry of quinoline-2-carbaldehyde derivatives with malononitrile and formation of indolizines." 2011. http://liblink.bsu.edu/uhtbin/catkey/1657738.

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The quinoline-5,8-diones are an important class of compounds with a wide spectrum of biological activites such as antibacterial, antiasthmatic, antifungal, antitumour and antiparasitic agents. Over the past three decades many variously substituted derivatives of quinoline-5,8-diones have been synthesized and reported. The majority of them dealt with the chemistry of C-6 and/or C-7 substituted quinolinediones and were related to Lavendamycin. Our lab has developed several procedures for the condensation (Knoevenagel) and reduction of aldehydes and ketones with malononitrile. When this reductive
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Lu, Chih Ming, and 盧智明. "Synthesis and Biological Evaluation of 6-Substituted Indolo[3,2-c]quinoline Derivatives." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/28444649406330255813.

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博士<br>高雄醫學大學<br>藥學研究所<br>100<br>The tetracyclic indoloquinoline ring system constitutes an important structural moiety in natural products exhibiting numerous biological activities. For example, cryptolepine (an indolo[3,2-b]quinoline derivative) and isocryptolepine (an indolo[3,2-c]quinoline derivative) are two indoloquinolines isolated from the roots of the african plant Cryptolepis sanguinolenta. Extensive investigations on the in vitro and in vivo biological activities of cryptolepine revealed its wide applications as anti-malarial, anti-microbial, anti-inflammatory, and anticancer agents.
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Hsu, Ming-Wei, and 許銘偉. "Pharmacokinetics of 4-Anilinofuro[2,3-b]quinoline Derivatives, New Synthetic Antitumor Compounds." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/55588372391863224163.

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碩士<br>高雄醫學大學<br>藥學研究所碩士班<br>92<br>1-[4-(furo[2,3-b]-quinolin-4-ylamino)phenyl]ethanone (PK-L1) and its analogue, 1-[4-(3-chlorofuro[2,3-b]-quinolin-4-ylamino)phenyl]ethanone (PK- L4), both these 4-anilino[2,3-b]quinoline derivatives are presently new synthetic anti-tumor compounds. These two compounds, PK-L1 and PK-L4, are just different in one chlorine replacement on the structure. In vitro study showed that they could inhibit most tumor cell growth, including liquid and solid tumors. PK-L1 and PK-L4, however, were passed only through in vitro study and had yet neither related plasma drug ana
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Huang, Ya-Ping, and 黃雅萍. "STUDY OF INDENO[1,2-C]QUINOLINE DERIVATIVES FOR ANTI-MYCOBACTERIUM TUBERCULOSIS ACTIVITIES." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/79703610160122011561.

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碩士<br>高雄醫學大學<br>醫學研究所<br>100<br>Tuberculosis (Mtb) is a disease caused by bacterium called Mycobacterium tuberculosis. According to the World Health Organization (WHO) reports, there are about 9 million new cases with Mycobacterium tuberculosis every year which caused more than 100 million people death. In recent years, the drug- resistant tuberculosis cases are increasing severely, especially the multidrug-resistant tuberculosis (MDR-TB). There are new cases with total drug-resistance defined by WHO in 2009. These cases illustrate that the development and discoveries of new anti-TB drugs in t
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Wu, Yun-Ching, and 吳昀靜. "Copper and Iron-Catalyzed Annulation Reactions for the Synthesis of Quinoline Derivatives." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/2x7a72.

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碩士<br>國立清華大學<br>化學系所<br>105<br>Quinoline derivatives are abundant in nature. Quinoline scaffold plays an important role in drug development as their derivatives have shown excellent biological activities. As a result, many scientists try hard to develop a more efficient way to synthesize quinoline derivatives. In this thesis, we selected copper and iron catalysts because of their plentiful resources and cheaper prices. Two methods about quinoline synthesis are demonstrated here. Chapter 1 shows an approach toward the synthesis of quinolines via copper (II) promoted amines, formaldehyde, and in
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