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Journal articles on the topic 'Quinoline derivative'

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Published: 4 June 2021

Last updated: 26 July 2025

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1

Shoji, Taku, Mutsumi Takeuchi, Mayumi Uda, et al. "Synthesis of Azuleno[2,1-b]quinolones and Quinolines via Brønsted Acid-Catalyzed Cyclization of 2-Arylaminoazulenes." Molecules 28, no. 15 (2023): 5785. http://dx.doi.org/10.3390/molecules28155785.

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Quinolone and quinoline derivatives are frequently found as substructures in pharmaceutically active compounds. In this paper, we describe a procedure for the synthesis of azuleno[2,1-b]quinolones and quinolines from 2-arylaminoazulene derivatives, which are readily prepared via the aromatic nucleophilic substitution reaction of a 2-chloroazulene derivative with several arylamines. The synthesis of azuleno[2,1-b]quinolones was established by the Brønsted acid-catalyzed intramolecular cyclization of 2-arylaminoazulene derivatives bearing two ester groups at the five-membered ring. The halogenat

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2

Rogerio, Kamilla Rodrigues, Cedric Stephan Graebin, Luiza Helena Pinto Domingues, et al. "Novel Quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione Derivatives Against Chloroquine-resistant Plasmodium falciparum." Current Topics in Medicinal Chemistry 20, no. 2 (2020): 99–110. http://dx.doi.org/10.2174/1568026619666191019100711.

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Introduction: In this work DHPMs were combined with the quinoline nucleus to obtain new quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione compounds with improved antiplasmodial activity as well as decreased cytotoxicity. Nineteen quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione derivatives connected by a linker group to quinolone ring moieties with different substituents were synthesized and assayed against P. falciparum. Materials and Methods: Nineteen quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione derivatives connected by a linker group to quinoline ring moieties with different substituents were syn

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3

R. Patel,, Dr Haresh. "An Application of Catalytic and Antimicrobial activity of Europium rare metal complex with Quinoline derivative." International Scientific Journal of Engineering and Management 04, no. 06 (2025): 1–9. https://doi.org/10.55041/isjem04437.

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Abstract: The combination of some rare metal ions with biologically important Quinoline derivative ligand to form coordination compound is an important area of current research. Less explored biologically important, Quinoline derivative ligand is allowed to react with solution of some rare metal perchlorates and attempt has been made to synthesize solid Quinoline derivative complexes. These Quinoline derivative complexes are subjected to U.V-Visible spectroscopy, IR spectroscopy, mass spectra, TGA analysis, elemental analysis etc. these complexes are used to study whether they possess catalyti

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4

Bremner, JB, та W. Jaturonrusmee. "Manganese(III) Acetate-Induced Formation of a Fused, Chloro-Substituted β-Lactam Derivative From a Chloroacetamide". Australian Journal of Chemistry 43, № 8 (1990): 1461. http://dx.doi.org/10.1071/ch9901461.

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Reaction of 1-chloroacetyl-5-methoxy-2,3-dihydro-1H-dibenzo[de,h]quinoline (1) with manganese(III) acetate in acetic acid at 50° gave the novel fused spiro derivative 11-chloro-4-methoxy-1,2-dihydro-6H-azeto[2,1-f]dibenzo[de,h]quinoline-6,12(11H)-dione (6) in 21% yield, together with 5-methoxy-7H-dibenzo[de,h]quinolin-7-one (3), 5-methoxy-2,3-dihydro-7H-dibenzo[de,h]quinolin-7-one (4), and 1- chloroacetyl-5-methoxy-2,3-dihydro-1H-dibenzo[de,h]-quinolin-7-yl ethanoate (5) in 1, 3 and 44% yields respectively. Compound (5) was shown to be a precursor of (3), (4) and (6).

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5

Wantulok, Jakub, Marcin Szala, Andrea Quinto, et al. "Synthesis, Electrochemical and Spectroscopic Characterization of Selected Quinolinecarbaldehydes and Their Schiff Base Derivatives." Molecules 25, no. 9 (2020): 2053. http://dx.doi.org/10.3390/molecules25092053.

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A new approach to the synthesis of selected quinolinecarbaldehydes with carbonyl groups located at C5 and/or in C7 positions is presented in this paper in conjunction with spectroscopic characterization of the products. The classical Reimer-Tiemann, Vilsmeier-Haack and Duff aldehyde synthesis methods were compared due to their importance. Computational studies were carried out to explain the preferred selectivity of the presented formylation transformations. A carbene insertion reaction based on Reimer-Tiemann methodology is presented for making 7-bromo-8-hydroxyquinoline-5-carbaldehyde. Addit

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6

Akhigbe, Joshua, Michael Luciano, Adewole O. Atoyebi, Steffen Jockusch, and Christian Brückner. "Quinoline-annulated porphyrin platinum complexes as NIR emitters." Journal of Porphyrins and Phthalocyanines 24, no. 01n03 (2020): 386–93. http://dx.doi.org/10.1142/s1088424619501256.

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The platinum(II) complexes of known quinoline-annulated porphyrins were prepared and spectroscopically characterized. Their optical properties (UV-vis absorption and phosphorescence spectra and phosphorescence lifetimes) were recorded and contrasted against their 2,3-dioxoporphyrin precursor platinum(II) complex. The absorbance and emission spectra (in EtOH glass at 77 K) of the quinoline-annulated porphyrins fall within the NIR optical window of tissue, ranging, depending on the derivative, between [Formula: see text]950 and 1200 nm. The much red-shifted optical spectra, when compared to thei

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7

Almansour, Abdulrahman I., Natarajan Arumugam, Saradh Prasad, et al. "Investigation of the Optical Properties of a Novel Class of Quinoline Derivatives and Their Random Laser Properties Using ZnO Nanoparticles." Molecules 27, no. 1 (2021): 145. http://dx.doi.org/10.3390/molecules27010145.

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Quinoline Schiff bases display potential applications in optoelectronics and laser fields because of their unique optical properties that arise from extensive delocalization of the electron cloud, and a high order of non-linearity. In this context, a new class of conjugated quinoline-derivative viz. N-(quinolin-3-ylmethylene)anilines were synthesized from 2-hydroxyquinoline-3-carbaldehyde in two good yielding steps. The ability of these imines to accept an electron from a donor is denoted by their electron acceptor number and sites, which is calculated using density functional theory (DFT). Th

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8

Yadav, Pradeep, and Y. C. Joshi. "Synthesis and Spectral Study of Novel Norfloxacin Derivatives." E-Journal of Chemistry 5, s2 (2008): 1154–58. http://dx.doi.org/10.1155/2008/357073.

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Reaction of [1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinolone-3-carboxylic acid (norfloxacin) with thiazole / benzothiazole diazonium chloride to get new piperazine substituted norfloxacin derivative. These norfloxacin derivatives were further condensed with variousβ-diketone to get novel acid derivatives of 1-Ethyl-6-fluoro-4-oxo-7- [4 (thiazol-2-yldiazenyl)-piperzin-1-yl]-1,4-dihydro-quinoline-3-carboxylic acid (6a-e) and 7-(4-(benzo[d]thiazol-2-yldiazenyl)piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid (6 f-j). Structures of these compounds were

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9

Bonyad, Ali Moin. "Synthesis of Chalcones from Acetone and tetrazole and 2-acetyl naphthalene Assisted by Microwave." Engineering and Technology Quarterly Reviews 3, no. 1 (2020): 16–22. https://doi.org/10.5281/zenodo.3686827.

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In the present study, we understood the total synthesis one chalcone derivative via Claisen-Schmidt condensation of the respective aldehydes and ketones using Microwave assisted irradiation method. In the microwave environment, chemical reactions usually proceed faster and give higher yields with fewer by- products. In the synthesis, a common aldehyde namely tetrazolo {1, 5-a} quinoline-4-carbaldehyde was used while the ketones used were respectively acetone, 2- acetyl Naphthalene. The Chalcone synthesised from Tetrazolo {1, 5-a} quinolone-4-carbaldehyde and acetone was 4-(tetrazolo {1, 5-a} q

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10

Rádl, Stanislav, and Viktor Zikán. "Synthesis of 1,2, and 9-methyl derivatives of 4,9-dihydro-6-methoxy-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline and 4,9-dihydro-6-hydroxy-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline and their antiviral activity." Collection of Czechoslovak Chemical Communications 52, no. 3 (1987): 788–92. http://dx.doi.org/10.1135/cccc19870788.

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The paper describes syntheses of 4,9-dihydro-6-methoxy-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline (Ia), its 1-methyl derivative (Ic), 1,9-dimethyl derivative (Ie), 2-methyl derivative (IIa), and 2,9-dimethyl derivative (IIc). Demethylation of these compounds with hydrobromic acid afforded 4,9-dihydro-6-hydroxy-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline (Ib), its 1-methyl derivative (Id), 1,9-dimethyl derivative (If), 2-methyl derivative (IIb), and 2,9-dimethyl derivative (IId) respectively. 4,9-Dihydro-6-hydroxy-3,9-dimethyl-4-oxo-1H-pyrazolo[3,4-b]quinoline (Ig) was prepared by demeth

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11

A.AlOmari, Nohad, Adnan O. Omar, and Iklas M. Taher. "Preliminary Cytotoxic Study of Some Novel Furo-2-quinolone Compounds." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 18, Suppl. (2017): 32–38. http://dx.doi.org/10.31351/vol18isssuppl.pp32-38.

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In this research, new series of Furo-2-quinolone [FQ] compounds have been synthesized. These novel [FQ] compounds were prepared from coumarin derivatives (Furocoumarins: psoralen and isopsoralen).Identifications of these FQ compounds were performed by using infrared spectrum (I.R), Ultraviolet spectrum (U.V) and Nuclear Magnetic Resonance spectrum (H1-NMR) besides some physical data. The cytotoxic screening involves ;using HEP-2 cell line which gave differential responses against tested compounds : 4,6 Dimethyl furo[2, 3-g] coumarin (C1), 1-(2`, 4`, Dimethoxy benzylideneimino)-2,6-dimethyl Fur

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12

Chokkar, Nisha, Sourav Kalra, Monika Chauhan, and Raj Kumar. "A Review on Quinoline Derived Scaffolds as Anti-HIV Agents." Mini-Reviews in Medicinal Chemistry 19, no. 6 (2019): 510–26. http://dx.doi.org/10.2174/1389557518666181018163448.

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After restricting the proliferation of CD4+T cells, Human Immunodeficiency Virus (HIV), infection persists at a very fast rate causing Acquired Immunodeficiency Syndrome (AIDS). This demands the vigorous need of suitable anti-HIV agents, as existing medicines do not provide a complete cure and exhibit drawbacks like toxicities, drug resistance, side-effects, etc. Even the introduction of Highly Active Antiretroviral Therapy (HAART) failed to combat HIV/AIDS completely. The major breakthrough in anti-HIV discovery was marked with the discovery of raltegravir in 2007, the first integrase (IN) in

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13

Morteza, Shiri, Nejatinezhad-Arani Atefeh, and Faghihi Zeinab. "Synthesis of Novel Quinoline-substituted 1,4-dihydropyridine Derivatives via Hantzsch Reaction in Aqueous Medium: Potential Bioactive Compounds." Journal of Heterocyclic Chemistry 54, no. 1 (2015): 131–36. https://doi.org/10.1002/jhet.2553.

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The synthesis of a novel series of substituted 1,4-dihydropyridines was achieved in aqueous media by base-catalyzed three-component Hantzsch reaction of 2chloroquinoline-3-carbaldehydes, ammonium acetate, and alkyl acteoacetate in good to high yields. Important advantages of this method are easy access to a library of novel quinoline and quinolone derivatives, green reaction conditions with water as solvent, and ease of purification.

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14

Goyal, Shawn, Beth Binnington, Stephen D. S. McCarthy, et al. "Inhibition of in vitro Ebola infection by anti-parasitic quinoline derivatives." F1000Research 9 (April 17, 2020): 268. http://dx.doi.org/10.12688/f1000research.22352.1.

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There continues to be no approved drugs for the treatment of Ebola virus disease (EVD). Despite a number of candidate drugs showing limited efficacy in vitro and/or in non-human primate studies, EVD continues to plaque certain areas of Africa without any efficacious treatments yet available. Recently, we have been exploring the potential for anti-malarial drugs to inhibit an in vitro model of Ebola Zaire replication using a transcription-competent virus-like particle (trVLP) assay. We examined the efficacy of chloroquine, amodiaquine and 36 novel anti-parasite quinoline derivatives at inhibiti

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15

Wojtyczka, Robert D., Andrzej Zięba, Arkadiusz Dziedzic, Małgorzata Kępa, and Danuta Idzik. "An Activity of Thioacyl Derivatives of 4-Aminoquinolinium Salts towards Biofilm Producing and Planktonic Forms of Coagulase-Negative Staphylococci." BioMed Research International 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/725939.

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Microorganisms present in different environments have developed specific mechanisms of settling on various abiotic and biotic surfaces by forming a biofilm. It seems to be well justified to search for new compounds enabling biofilm reduction, which is highly resistant to antibiotics. This study was thus an initial assessment of the antibacterial activity of two new quinoline derivatives of a structure of 3-thioacyl 1-methyl 4-arylaminoquinolinium salts against coagulase-negative staphylococci (CoNS) isolated from a hospital environment, in a form of both biofilms and in planktonic form. Thirty

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16

Kovács, Édua, Hazhmat Ali, Renáta Minorics, et al. "Synthesis and Antiproliferative Activity of Steroidal Diaryl Ethers." Molecules 28, no. 3 (2023): 1196. http://dx.doi.org/10.3390/molecules28031196.

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Novel 13α-estrone derivatives have been synthesized via direct arylation of the phenolic hydroxy function. Chan–Lam couplings of arylboronic acids with 13α-estrone as a nucleophilic partner were carried out under copper catalysis. The antiproliferative activities of the newly synthesized diaryl ethers against a panel of human cancer cell lines (A2780, MCF-7, MDA-MB 231, HeLa, SiHa) were investigated by means of MTT assays. The quinoline derivative displayed substantial antiproliferative activity against MCF-7 and HeLa cell lines with low micromolar IC50 values. Disturbance of tubulin polymeriz

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17

Rádl, Stanislav, and Viktor Zikán. "Syntheses of some 4-dialkylaminoalkylamino derivatives of 2,3-dimethyl-2H- and 3,9-dimethyl-9H-pyrazolo[3,4-b]quinoline." Collection of Czechoslovak Chemical Communications 51, no. 8 (1986): 1692–97. http://dx.doi.org/10.1135/cccc19861692.

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Reactions of 4-chloro-2,3-dimethyl-2H-pyrazolo[3,4-b]quinoline and 4-chloro-6-methoxy-2,3-dimethyl-2H-pyrazolo[3,4-b]quinoline with 3-dimethylaminopropylamine and/or 2-dimethylaminoethylamine afforded 4-(3-dimethylaminopropylamino)-2,3-dimethyl-2H-pyrazolo[3,4-b]quinoline (IIa), its 6-methoxy derivative (IIc), 4-(2-diethylaminoethylamino)-2,3-dimethyl-2H-pyrazolo[3,4-b]quinoline (IIb) and its 6-methoxy derivative (IId). Reaction of 4,9-dihydro-3,9-dimethyl-4-oxo-1H-pyrazolo[3,4-b]quinoline with thionyl chloride gave an intermediate, whose reaction with 3-dimethylaminopropylamine afforded 4-(3-

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18

Rodríguez, Ricaurte, Omar León, Felipe Quiroga, and Jonnathan Cifuentes. "N-{2-[(3-Oxo-1,3-dihydro-2-benzofuran-1-yl)acetyl]phenyl}acetamide." Molbank 2021, no. 3 (2021): M1244. http://dx.doi.org/10.3390/m1244.

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With the aim of obtaining different derivatives belonging to the isoindolo[2,1-a]quinoline family, we have synthesized a novel N-{2-[(3-oxo-1,3-dihydro-2-benzofuran-1-yl)acetyl]phenyl}acetamide derivative by a Claisen–Smichdt-type condensation reaction in 75% yield.

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19

Girges, Margret Mansour, Mokhtar Ayad Hanna, Hussien Mohamed Hassan, and Evelin Boshra Moawad. "Synthesis of some new 3-substituted-4-hydroxy-1-methyl-quinolin-2-one derivatives as potential antibacterial and antifungal agents." Collection of Czechoslovak Chemical Communications 53, no. 12 (1988): 3179–83. http://dx.doi.org/10.1135/cccc19883179.

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3-Acetyl-4-hydroxy-1-methylquinolin-2-one (I) and its bromo derivative II were allowed to react with different reagents to get new quinoline derivatives that have different heterocyclic moieties at position 3. The antibacterial and antifungal activities of the products were also evaluated.

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20

Rádl, Stanislav, and Viktor Zikán. "Synthesis and biological activity of some basic-substituted 4,9-dihydro-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinolines." Collection of Czechoslovak Chemical Communications 53, no. 8 (1988): 1812–19. http://dx.doi.org/10.1135/cccc19881812.

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Compounds Ia, Ib were obtained by an alkylation of 4,9-dihydro-6-hydroxy-1,3,9-trimethyl-4-oxo-1H-pyrazolo[3,4-b]quinoline (VIIb) with the respective dialkylaminoalkyl chloride. The same alkylation of 4,9-dihydro-6-hydroxy-2,3,9-trimethyl-4-oxo-2H-pyrazolo[3,4-b]quinoline (VIIIb) yielded compounds IIa and IIb. Similar alkylation of 4,9-dihydro-6-hydroxy-3,9-dimethyl-4-oxo-1H-pyrazolo[3,4-b]quinoline (IXa) and its 6-methoxy derivative (IXb) afforded IIIa-IIId. Compound IV was prepared from 4-chloro-3-methyl-1H-pyrazolo[3,4-b]quinoline (Xa) via its 1-(3-dimethylaminopropyl)derivative (Xb). Compo

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21

Bender, Matthias, and Jens Christoffers. "Investigations into the Regioselectivity of Fischer Indole and Friedländer Quinoline Syntheses with Octahydroisobenzofuran and Octahydroisoindole Derivatives." Zeitschrift für Naturforschung B 66, no. 12 (2011): 1209–18. http://dx.doi.org/10.1515/znb-2011-1203.

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A Fischer indole synthesis with a cis-configurated octahydroisobenzofuran-6-one yielded exclusively a furo[3,4-c]carbazole derivative as the product of a regioselective angular annulation reaction. A Friedländer quinoline synthesis from the same substrate gave a mixture of angular and linear annulation products, i. e. furo[3,4-a]acridine and furo[3,4-b]acridine derivatives. When submitting a mixture of cis- and trans-octahydroisoindole derivatives to Fischer and Friedländer syntheses, the trans-starting material gave regioselectively linear annulation products, i. e. pyrrolo[3,4-b]carbazole an

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22

Hidayah, Nurul, Bambang Purwono, and Ika Dyah Kumalasari. "A Novel Synthesis Route of Phenyl Quinoline from Nitrochalcone with Hydrazine Hydrate in the Presence of Pd/C." Key Engineering Materials 989 (October 28, 2024): 79–86. http://dx.doi.org/10.4028/p-17rfom.

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Quinoline is widely known to have many biological activities. Therefore, the development of the synthesis method of a quinoline derivative framework is a priority. A phenyl quinoline derivative, 6,7-dimethoxy-2-phenylquinoline Q1, has been successfully synthesized via a novel one-pot reaction that involves reduction, cyclization, and followed by dehydration of nitrochalcone derivate, 3-(4,5-dimethoxy-2-nitrophenyl)-1-phenylprop-2-en-1-one C1. The reaction was carried out using 80 % hydrazine hydrate in the presence of 10% Pd/C as a catalyst in an ethanol medium. Target compound Q1 was afforded

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23

Vora, J. J., S. B. Vasava, Asha D. Patel, K. C. Parmar, S. K. Chauhan, and S. S. Sharma. "Synthesis, Characterization and Antibacterial Activity of a New Series of s-Triazines Derived with Quinolines." E-Journal of Chemistry 6, no. 1 (2009): 201–6. http://dx.doi.org/10.1155/2009/812341.

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8-Hydroxy quinoline was synthesized using Skraup reaction. This was condensed with trichloro-s-triazine. The product of the above reaction was allowed to react with triazole derivative. Finally, urea derivatives were allowed to react and the products were characterized by conventional and instrumental methods. Their structures were determined and important biochemical properties were studied

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24

Wang, Linqing, Rui Guo, Xiaorui Liang, et al. "Preparation and Antioxidant Activity of New Carboxymethyl Chitosan Derivatives Bearing Quinoline Groups." Marine Drugs 21, no. 12 (2023): 606. http://dx.doi.org/10.3390/md21120606.

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A total of 16 novel carboxymethyl chitosan derivatives bearing quinoline groups in four classes were prepared by different synthetic methods. Their chemical structures were confirmed by Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and elemental analysis. The antioxidant experiment results in vitro (including DPPH radical scavenging ability, superoxide anion radical scavenging ability, hydroxyl radical scavenging ability, and ferric reducing antioxidant power) demonstrated that adding quinoline groups to chitosan (CS) and carboxymethyl chitosan (CMCS) enhanc

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25

Erguc, Ali, Mehlika Dilek Altintop, Ozlem Atli, et al. "Synthesis and Biological Evaluation of New Quinoline-Based Thiazolyl Hydrazone Derivatives as Potent Antifungal and Anticancer Agents." Letters in Drug Design & Discovery 15, no. 2 (2018): 193–202. http://dx.doi.org/10.2174/1570180814666171003145227.

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Background: In medicinal chemistry, thiazoles have gained great importance in antifungal and anticancer drug design and development. Objectives: The aim of this study was to synthesize new quinoline-based thiazolyl hydrazone derivatives and evaluate their anticandidal and anticancer effects. Methods: New thiazolyl hydrazone derivatives were evaluated for their anticandidal effects using disc diffusion method. Ames MPF assay was carried out to determine the genotoxicity of the most effective antifungal derivative. MTT assay was also performed to assess the cytotoxic effects of the compounds on

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26

Li, Qian, Qitong Huang, Jie-Ji Zhu, Wen-Gang Ji, and Qing-Xiao Tong. "Carbon dots–quinoline derivative nanocomposite: facile synthesis and application as a “turn-off” fluorescent chemosensor for detection of Cu2+ ions in tap water." RSC Advances 6, no. 90 (2016): 87230–36. http://dx.doi.org/10.1039/c6ra21034a.

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In this paper, a novel quinoline derivative: 8-(pyridin-2-ylmethoxy)quinoline-2-carboxylic acid (Q) has been successfully synthesized, then it was coupled with carbon dots (CDs) to synthesize a CDs–Q nanocomposite by a simple and green method.

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27

Pratama, Mohammad Rizki Fadhil. "Studi Docking Molekular Senyawa Turunan Kuinolin Terhadap Reseptor Estrogen-?" Jurnal Surya Medika 2, no. 1 (2016): 1–7. http://dx.doi.org/10.33084/jsm.v2i1.215.

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Estrogen-a (ER-a) is the main target for ER + therapy. Inhibition of ER-a is known to slow the proliferation of ER + breast cancer cells. Quinoline derivatives are known to have anticancer activity by inhibiting several types of receptors. It is not known whether quinoline can inhibit ER-a. This study aims to determine the interaction between ER-a with quinoline derivative compounds. Molecular docking of ER-a showed that quinine gave the most negative bond-free energy and the smallest inhibition constant, respectively -8.73 kcal/mol and 0.398 �M. These results provide predictions that quinine

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28

Chi, Nguyen Thi Thanh, Pham Van Thong, Truong Thi Cam Mai, and Luc Van Meervelt. "Mixed natural arylolefin–quinoline platinum(II) complexes: synthesis, structural characterization and in vitro cytotoxicity studies." Acta Crystallographica Section C Structural Chemistry 74, no. 12 (2018): 1732–43. http://dx.doi.org/10.1107/s2053229618015978.

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Five new platinum(II) complexes bearing a eugenol and a quinoline derivative, namely [η2-4-allyl-2-methoxy-1-(propoxycarbonylmethoxy)benzene]-trans-dichlorido(quinoline-κN)platinum(II), [PtCl2(C15H20O4)(C9H7N)], (2), {η2-4-allyl-2-methoxy-1-[(propan-2-yloxy)carbonylmethoxy]benzene}-trans-dichlorido(quinoline-κN)platinum(II), [PtCl2(C15H19O4)(C9H7N)], (3), [η2-4-allyl-2-methoxy-1-(propoxycarbonylmethoxy)benzene]chlorido(quinolin-8-olato-κ2 N,O)platinum(II), [Pt(C9H6NO)Cl(C15H20O4)], (4), {η2-4-allyl-2-methoxy-1-[(propan-2-yloxy)carbonylmethoxy]benzene}chlorido(quinolin-8-olato-κ2 N,O)platinum(I

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29

Hamama, Wafaa S., Mohamed A. Ismail, Hana’a A. Al-Saman, and Hanafi H. Zoorob. "Convenient Selective Synthesis of Substituted Pyrido[2,3-d]pyrimidones and Annulated Derivatives." Zeitschrift für Naturforschung B 62, no. 1 (2007): 104–10. http://dx.doi.org/10.1515/znb-2007-0115.

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The reaction of 6-aminouracil (1) with the appropriate α,β -unsaturated ketones, gave the corresponding pyrido[2,3-d]pyrimidin-2,4-diones 3, 6, 8 and 10, respectively. Treatment of 1 with salicylaldehyde, 6-carboethoxy-3,5-diphenyl-2-cyclohexenone (13) or 2,6- bis(phenylmethylidene)cyclohexanone (15) afforded the corresponding pyrimido[4,5-d]quinoline- 2,4-diones 12, 14 and 16, respectively. Furthermore, a pyrido[2,3-d]pyrimidine incorporating 3,2’- bis(quinoline) derivative 18 was synthesized. Annulation of pyrido[2,3-d]pyrimidine with pyrazole or imidazole moieties was achieved via reaction

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30

Muchowski, Joseph M., and Michael L. Maddox. "Concerning the mechanism of the Friedländer quinoline synthesis." Canadian Journal of Chemistry 82, no. 3 (2004): 461–78. http://dx.doi.org/10.1139/v03-211.

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Detailed experiments regarding the mechanism of the Friedländer synthesis of quinolines from o-aminobenzaldehydes and simple aldehydes or ketones are described. Under the basic or acidic conditions commonly used in this reaction, it is concluded that the first step involves a slow intermolecular aldol condensation of the aldehyde or ketone with the o-aminobenzaldehyde. The aldol adduct 5 generated in this manner then undergoes very rapid cyclization to 4, which subsequently loses water to produce the quinoline derivative 8. Both 5 and 4 are too short lived to be detectable (TLC), even when del

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31

Smith, Aaron T., Meredith R. Livingston, Antonello Mai, Patrizia Filetici, Sherry F. Queener, and William J. Sullivan. "Quinoline Derivative MC1626, a Putative GCN5 Histone Acetyltransferase (HAT) Inhibitor, Exhibits HAT-Independent Activity against Toxoplasma gondii." Antimicrobial Agents and Chemotherapy 51, no. 3 (2006): 1109–11. http://dx.doi.org/10.1128/aac.01256-06.

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ABSTRACT We report that quinoline derivative MC1626, first described as an inhibitor of the histone acetyltransferase (HAT) GCN5, is active against the protozoan parasite Toxoplasma gondii in vitro. However, MC1626 does not inhibit Toxoplasma GCN5 HATs or reduce HAT-mediated activity; rather, this quinoline may target the plastid organelle called the apicoplast.

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Ma, Juan, and Guo-Hua Gong. "Discovery of Novel 3,4-Dihydro-2(1H)-Quinolinone Sulfonamide Derivatives as New Tubulin Polymerization Inhibitors with Anti-Cancer Activity." Molecules 27, no. 5 (2022): 1537. http://dx.doi.org/10.3390/molecules27051537.

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In this paper, a small series of novel quinoline sulfonamide derivatives was synthesized, and their structure of the target compounds were confirmed by 1H NMR and MS. The screening of the news target compounds’ in vitro cytotoxic activities against tumor cell lines by the MTT method was performed. Among them, compound D13 (N-(4-methoxybenzyl)-2-oxo-N-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydroquinoline-6-sulfonamide exhibited the strongest inhibitory effect on the proliferation of HeLa (IC50: 1.34 μM), and this value correlated well with the inhibitory activities of the compound against tubuli

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Sakshi, Soam, and Dasgupta Sreela. "Effect of Substituents on the Biological Activity of Isatin Hybrids – A SAR Study." International Journal of Current Science Research and Review 06, no. 03 (2023): 1961–67. https://doi.org/10.5281/zenodo.7726585.

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<strong>ABSTRACT: </strong>Isatin (2,3-dioxindole) is a benzopyrrole derivative that belongs to a large class of heterocyclic chemicals. Isatin derivatives are essential synthetic substrates that can be utilized as starting materials to build a wide range of heterocycles with diverse applications in pharmaceutical sciences. Isatin derivatives therefore have recently gained a lot of attention. This review emphasizes on the Schiff base derivatives from isatin, isatin quinoline/flouroquinone, isatin -thiazole, isatin–azole hybrids, all possessing potential biological activity. The structure

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Lubis, Siti Masitah, Muhamad Fadhly Hariadi, Nilna Amalia, et al. "One-Pot Synthesis and Antioxidant Activity of 4-Phenoxyquinoline Derivative from Clove Leaf Oil." Materials Science Forum 1068 (August 19, 2022): 161–66. http://dx.doi.org/10.4028/p-3q70s0.

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Synthesis and antioxidant assay of 4-phenoxyquinoline derivative namely, (E)-7-chloro-4-(2-methoxy-4-(prop-1-en-1-yl)phenoxy)quinoline, from clove leaf oil have been conducted. This compound can be prepared from eugenol (isolated from clove leaf oil) in either two-step or one-pot synthesis. In two-step synthesis, eugenol was subjected to base-catalyzed-isomerization to give isoeugenol, which in turn underwent aromatic nucleophilic aromatic nucleophilic substitution with 4,7-dichloroquinoline to generate (E)-7-chloro-4-(2-methoxy-4-(prop-1-en-1-yl)phenoxy)quinoline in 57% total yields. By combi

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35

Gomes, Ligia R., John Nicolson Low, Fernanda Borges, Alexandra Gaspar, and Francesco Mesiti. "The synthesis, crystal structure and Hirshfeld analysis of 4-(3,4-dimethylanilino)-N-(3,4-dimethylphenyl)quinoline-3-carboxamide." Acta Crystallographica Section E Crystallographic Communications 76, no. 2 (2020): 201–7. http://dx.doi.org/10.1107/s2056989020000298.

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The structure of the title quinoline carboxamide derivative, C26H25N3O, is described. The quinoline moiety is not planar as a result of a slight puckering of the pyridine ring. The secondary amine has a slightly pyramidal geometry, certainly not planar. Both intra- and intermolecular hydrogen bonds are present. Hirshfeld surface analysis and lattice energies were used to investigate the intermolecular interactions.

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36

Kiruthika, S., and V. Sharulatha. "Evaluation of Free Radical Quenching Ability of Quinoline Acids through in vitro and Theoretical Studies." Asian Journal of Chemistry 35, no. 8 (2023): 1985–94. http://dx.doi.org/10.14233/ajchem.2023.28028.

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Drugs based antioxidants are commonly suggested as targets while designing new medicines. All sorts of pharmaceutical drug development benefit from the extremely desirable quinoline moiety with antioxidant. In this work, the scavenging behaviour of four quinoline derivatives (Q1-Q4) towards DPPH, H2O2, ABTS and superoxide activity were investigated. According to the in vitro inhibition concentration (IC50), quinoline derivative Q1 showed high antioxidant potential. Additionally, the theoretical DFT gas phase calculations of HOMO-LUMO, MEP, NPA and NBO are used to study the conjugating systems

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37

Hubel, Roland, Tomas Jelinek, and Wolfgang Beck. "Metal Complexes of Biologically Important Ligands, CXXV [1]. Palladium(II) and Platinum(II) Complexes of Quinine Derivatives and in vitro Tests." Zeitschrift für Naturforschung B 55, no. 9 (2000): 821–33. http://dx.doi.org/10.1515/znb-2000-0906.

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Several quinine substituted derivatives at the C(9)-O position (1 - 7) have been obtained from quinine and N-protected glycine chloride, chlorocarbonyl ferrocene, phenylisocyanate, dicarboxylic acid dichlorides or trimesinic trichloride. From these only the glycine derivative 1 showed significant antimalarial activity in in vitro tests against Plasmodium falciparum isolates. The quinine derivatives were used as ligands and from chloro bridged palladium and platinum complexes Cl(R3P)M(μ-Cl)2M(PR3)Cl (M = Pd, Pt) di-, tri-, tetra- and hexametallic compounds 8-21 with coordination both of the ali

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38

Bouzian, Younos, Md Serajul Haque Faizi, Joel T. Mague, et al. "Crystal structure and DFT study of benzyl 1-benzyl-2-oxo-1,2-dihydroquinoline-4-carboxylate." Acta Crystallographica Section E Crystallographic Communications 75, no. 7 (2019): 980–83. http://dx.doi.org/10.1107/s2056989019007989.

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In the title quinoline derivative, C24H19NO3, the two benzyl rings are inclined to the quinoline ring mean plane by 74.09 (8) and 89.43 (7)°, and to each other by 63.97 (10)°. The carboxylate group is twisted from the quinoline ring mean plane by 32.2 (2)°. There is a short intramolecular C—H...O contact forming an S(6) ring motif. In the crystal, molecules are linked by bifurcated C—H,H...O hydrogen bonds, forming layers parallel to the ac plane. The layers are linked by C—H...π interactions, forming a supramolecular three-dimensional structure.

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Luna Parada, Luz, and Vladimir Kouznetsov. "5-Chloro-8-{[1-(2-chlorobenzyl)-1H-1,2,3-triazol-4-yl]methoxy}quinoline." Molbank 2019, no. 1 (2018): M1038. http://dx.doi.org/10.3390/m1038.

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The title quinoline derivative, 5-chloro-8-{[1-(2-chlorobenzyl)-1H-1,2,3-triazol-4-yl]methoxy}quinoline, was synthesized in a common three-step procedure from 5-chloro-8-hydroxyquinoline using O-propargylation reaction/copper-catalyzed 1,3-dipolar cycloaddition sequence. The structure of the compound was fully characterized by FT-IR, 1H- and 13C-NMR, GC-MS, and elemental analysis. Its physicochemical parameters (Lipinski’s descriptors) were also calculated using the Molinspiration Cheminformatics software. The hybrid obtained could be an interesting model for antifungal bio-essays or a suitabl

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40

T. Male, Yusthinus, I. W. Sutapa, I. B. Kapelle, and M. Lopulalan. "QSAR MODELING AND DESIGN OF A NEW MODEL OF ANTIHIV DRUG 1-ARYL-TETRAHYDROISOQUINOLINE DERIVED USING THE PM3 SEMIEMPIRICAL METHOD." Rasayan Journal of Chemistry 15, no. 01 (2022): 359–68. http://dx.doi.org/10.31788/rjc.2022.1516479.

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Quantitative Structure-Activities Relationship Analysis (QSAR) on the 1-aryl-tetrahydroisoquinoline derivative as a candidate for the anti-HIV drug (Human Immunodeficiency Virus) has been done. The analysis using an electronic descriptor of atomic net charge, dipole moment, polarization, HOMO-LUMO energy, and log P was calculated using the PM3 semiempirical method. The best equation model is determined using multilinear regression analysis. The QSAR analysis show that the best QSAR equation model of 1-aryl-tetrahydroisoquinoline derivatives: pEC50= -23.019-10.867(qC3)-162.911(qC4)-107.057(qC6)

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Mashelkar, Uday, Mukesh Jha, and Beena Mashelkar. "Synthesis of 2-azetidinones substituted quinoline derivative." Journal of the Serbian Chemical Society 78, no. 5 (2013): 621–25. http://dx.doi.org/10.2298/jsc120617081m.

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Acetanilide is converted into 2-chloro-3-formyl quinoline by reacting with DMF-POCl3 at 80-90?C and then condensed with aromatic primary amines to give Schiff bases (3a-3c). These Schiff bases are then reacted with acid chlorides in the presence of base in toluene to give 1, 3, 4-substituted 2-azetidinones.

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42

Rádl, Stanislav, Viktor Zikán, and František Šmejkal. "Syntheses of 1, 2, and 9-methyl derivatives of 4,9-dihydro-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline and their antiviral activity." Collection of Czechoslovak Chemical Communications 50, no. 5 (1985): 1057–63. http://dx.doi.org/10.1135/cccc19851057.

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The paper describes syntheses of 4,9-dihydro-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline (Ia), its 1-methyl derivative (Ib), 2-methyl derivative (IIa), 9-methyl derivative (Ic), 1,9-dimethyl derivative (Id) and 2,9-dimethyl derivative (IIb). Sodium salts of compounds Ia, Ib, Ic and IIa were methylated with methyl iodide in dimethylformamide at room temperature, compounds Id and IIb were demethylated with pyridine hydrochloride. The compounds prepared were tested for antiviral activity in vivo in mice against influenza virus A2-Hongkong and the Encephalomyocarditis virus.

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43

Aparicio Acevedo, Deiby F., Marlyn C. Ortiz Villamizar, and Vladimir V. Kouznetsov. "Three-Step Synthesis of N-(7-chloro-4-morpholinoquinolin-2-yl)benzamide from 4,7-Dichloroquinoline." Molbank 2024, no. 1 (2024): M1796. http://dx.doi.org/10.3390/m1796.

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The quinoline derivative, N-(7-chloro-4-morpholinoquinolin-2-yl)benzamide, was synthesized in a conventional three-step procedure from 4,7-dichloroquinoline using a N-oxidation reaction/C2-amide formation reaction/C4 SNAr reaction sequence. The structure of the compound was fully characterized by FT-IR, 1H-, 13C-NMR, DEPT-135°, and ESI-MS techniques. Its physicochemical parameters (Lipinski’s descriptors) were also calculated using the online SwissADME database. Such derivatives are relevant therapeutic agents exhibiting potent anticancer, antibacterial, antifungal, and antiparasitic propertie

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Li, Yongming, Dingli Wang, and Lei Zhang. "Experimental and theoretical research on a new corrosion inhibitor for effective oil and gas acidification." RSC Advances 9, no. 45 (2019): 26464–75. http://dx.doi.org/10.1039/c9ra04638k.

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Gómez, E., C. Müller, and E. Vallés. "Phase transitions in mercury-quinoline derivative systems." Journal of Electroanalytical Chemistry and Interfacial Electrochemistry 215, no. 1-2 (1986): 345–55. http://dx.doi.org/10.1016/0022-0728(86)87027-9.

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Müller, C., J. Claret, F. Martinez, and M. Sarret. "Phase transitions in mercury + quinoline derivative systems." Journal of Electroanalytical Chemistry and Interfacial Electrochemistry 202, no. 1-2 (1986): 203–15. http://dx.doi.org/10.1016/0022-0728(86)90119-1.

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47

Bohdan, Anna, Yanina Romanenko, Mikhail Zavhorodnii, et al. "Design, Synthesis and Biological Activity of the 4-Thioquinoline Derivative." Chemistry & Chemical Technology 17, no. 4 (2023): 774–85. http://dx.doi.org/10.23939/chcht17.04.774.

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One of the promising areas in the creation of bioregulators is the modeling of compounds that combine several pharmacophores. The design of new highly efficient and low-toxic cytoprotectors is largely based on the derivatives of nitrogen-containing heterocycles, and quinoline plays a significant role among these compounds. The researchers evaluated the toxicity of the tested compounds in silico, in vitro, and in vivo, which allowed determiningseveral factors that affect the level of toxic action of 4-thioquinoline derivatives and the direction of non-toxic substances in this sequence. The stud

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Lu, Jia-Xing, Hai-Rong Lan, Dai Zeng, et al. "Design, synthesis, anticancer activity and molecular docking of quinoline-based dihydrazone derivatives." RSC Advances 15, no. 1 (2025): 231–43. https://doi.org/10.1039/d4ra06954d.

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Shockravi, Abbas, Shahram Mehdipour-Ataei, and Esmael Rostami. "BINOL Macrocycle Derivatives: Synthesis of New Dinaphthyl Sulfide Aza Oxa Thia Crowns (Lariats)." Journal of Chemistry 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/598937.

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In this research work, dinaphthyl sulfide diester was prepared from the reaction of 1,1′-thiobis (2-hydroxy naphthalene) and methylchloroacetate. Its aza-macrocyclic derivative was synthesized from the reaction of dinaphthyl sulfide diester and diethylenetriamine. Lariats were prepared from the reaction of chloroamides (four derivatives) and initial macrocycle. Chloroamides were synthesized from the reaction of amines (aniline, benzylamine, 8-amino quinoline and 4-amino azobenzene) and chloroacetyl chloride. All the materials were identified by IR,1H NMR,13C NMR, and mass spectroscopies, and e

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Li, Barbara T. Y., Jonathan M. White, and Craig A. Hutton. "Synthesis of the Leu - Trp Component of the Celogentin Family of Cyclic Peptides Through a C - H Activation - Cross-Coupling Strategy." Australian Journal of Chemistry 63, no. 3 (2010): 438. http://dx.doi.org/10.1071/ch10033.

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A bioinspired approach to the central leucine(C3)–tryptophan(C6) cross-linked moiety present in the celogentin family of cyclic peptide natural products was achieved. The key transformation was enabled through a palladium-catalyzed C–H activation–cross-coupling of leucine quinoline amide and 6-iodotryptophan derivatives. X-Ray crystallographic analysis of a β-(indol-6-yl)-leucine derivative confirms the stereochemistry of the cross-linked adduct matches that of the natural products. The method enables the preparation of the Leu–Trp adduct as a single stereoisomer from l-leucine and l-tryptopha

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