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Relevant bibliographies by topics / Quinoline ring derivatives

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Academic literature on the topic 'Quinoline ring derivatives'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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Journal articles on the topic "Quinoline ring derivatives"

1

Shoji, Taku, Mutsumi Takeuchi, Mayumi Uda, et al. "Synthesis of Azuleno[2,1-b]quinolones and Quinolines via Brønsted Acid-Catalyzed Cyclization of 2-Arylaminoazulenes." Molecules 28, no. 15 (2023): 5785. http://dx.doi.org/10.3390/molecules28155785.

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Quinolone and quinoline derivatives are frequently found as substructures in pharmaceutically active compounds. In this paper, we describe a procedure for the synthesis of azuleno[2,1-b]quinolones and quinolines from 2-arylaminoazulene derivatives, which are readily prepared via the aromatic nucleophilic substitution reaction of a 2-chloroazulene derivative with several arylamines. The synthesis of azuleno[2,1-b]quinolones was established by the Brønsted acid-catalyzed intramolecular cyclization of 2-arylaminoazulene derivatives bearing two ester groups at the five-membered ring. The halogenat

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Rogerio, Kamilla Rodrigues, Cedric Stephan Graebin, Luiza Helena Pinto Domingues, et al. "Novel Quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione Derivatives Against Chloroquine-resistant Plasmodium falciparum." Current Topics in Medicinal Chemistry 20, no. 2 (2020): 99–110. http://dx.doi.org/10.2174/1568026619666191019100711.

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Introduction: In this work DHPMs were combined with the quinoline nucleus to obtain new quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione compounds with improved antiplasmodial activity as well as decreased cytotoxicity. Nineteen quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione derivatives connected by a linker group to quinolone ring moieties with different substituents were synthesized and assayed against P. falciparum. Materials and Methods: Nineteen quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione derivatives connected by a linker group to quinoline ring moieties with different substituents were syn

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Zhang, Xiaofeng, Miao Liu, Weiqi Qiu, and Wei Zhang. "2-Azidobenzaldehyde-Based [4+2] Annulation for the Synthesis of Quinoline Derivatives." Molecules 29, no. 6 (2024): 1241. http://dx.doi.org/10.3390/molecules29061241.

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Quinoline is a privileged heterocyclic ring which can be found in many drug molecules and bioactive compounds. The development of synthetic methods for making quinoline derivatives continuously attracts the interest of organic and medicinal chemists. This paper highlights 2-azidobenzaldehyde-based [4+2] annulation for the synthesis of quinoline derivatives including fused and spiro-quinolines, quinoline-4-ols, 4-aminoquinolines, and related compounds.

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Srinivas, Sangu*and Anil Kumar Middha. "SYNTHESIS, ANTI MICROBIAL, ANTI CANCER EVALUTION AND MOLECULAR DOCKING STUDIES OF QUINAZOLINYL THIADIAZOLES DERIVATIVES." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 11 (2018): 11458–65. https://doi.org/10.5281/zenodo.1477785.

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<em>Quinazoline derivatives are reported to have anti microbial, anti inflammatory, analgesic and anti cancer activities. The incorporated oxymethyl carbamide at 4<sup>th</sup> position of the quinoline ring was found to influence the biological activities of the molecules with this some of new Quinolinyl- oxymethyl -thiadiazoles synthesized from 4-hydroxy quinoline through (quinolin-4yloxy) acetyl hydrazide intermediates. All the synthesized compounds were characterized by IR, H<sup>1</sup>NMR spectral data and carried out molecular docking studies against calcium/calmoduline dependent protei

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Khidre, Rizk E., Ibrahim Ali M. Radini, and Diaa A. Ibrahim. "Synthetic Approaches of Pyrazolyl Quinolines." Mini-Reviews in Organic Chemistry 16, no. 4 (2019): 353–60. http://dx.doi.org/10.2174/1570193x15666180419142511.

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This review article represents a survey of the synthetic strategies leading to pyrazolyl quinolines. The synthetic methods are divided into two main groups based on the type of starting reagents: 1) From quinoline ring onto a pyrazole scaffold, 2) From pyrazole ring onto a quinoline scaffold. Also, some medical applications of pyrazolyl quinoline derivatives are mentioned such as anticancer, cell proliferative disorder, glucose transport inhibitors, anti-inflammatory, and inhibitors of leukotriene production for the treatment of cardiovascular. The main purpose of this review is to present a s

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Garudachari, Bhadrachari, and Arun Mohan Isloor. "Substituted Quinoline Derivatives as Potent Biological Agents." Advanced Materials Research 995 (July 2014): 61–84. http://dx.doi.org/10.4028/www.scientific.net/amr.995.61.

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Quinoline derivatives are the most promising class of active pharmaceutical agents compared with other heterocyclic compounds. Biological activity profile of quinoline can easily be controlled by introducing some active pharmacophore to the core ring. This chapter deals with the synthesis of quinoline derivatives and its biological activity. The enhancement of biological activity by incorporation of active functional group and effect of these functional groups were explained briefly. Main focus is given to the synthesis of different substituted quinoline derivatives for biological application

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Swapna, Sahu, Srivastava Shobhit, and Kumar Gupta Sujeet. "A Review on Quinoline: Diverse Pharmacological Agent." Chemistry Research Journal 6, no. 4 (2021): 81–96. https://doi.org/10.5281/zenodo.11666866.

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<strong>Abstract </strong>Quinoline is a heterocyclic aromatic organic & fused ring compound with the Chemical formula C<sub>9</sub>H<sub>7</sub>N.  Quinoline is an important pharmacophore in medicinal chemistry, since a large number of its derivatives possess useful biological properties. Also, Quinolones are known for their formation of conjugated molecules and polymers that combine enhanced electronic, optoelectronic, or nonlinear optical properties with excellent mechanical properties. They have a crucial role in the synthesis of various new therapeutic agents. For new drug develo

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Nyamwihura, Rogers J., Huaisheng Zhang, Jasmine T. Collins, Olamide Crown, and Ifedayo Victor Ogungbe. "Nopol-Based Quinoline Derivatives as Antiplasmodial Agents." Molecules 26, no. 4 (2021): 1008. http://dx.doi.org/10.3390/molecules26041008.

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Malaria remains a significant cause of morbidity and mortality in Sub-Saharan Africa and South Asia. While clinical antimalarials are efficacious when administered according to local guidelines, resistance to every class of antimalarials is a persistent problem. There is a constant need for new antimalarial therapeutics that complement parasite control strategies to combat malaria, especially in the tropics. In this work, nopol-based quinoline derivatives were investigated for their inhibitory activity against Plasmodium falciparum, one of the parasites that cause malaria. The nopyl-quinolin-8

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Ambatkar, Megha P., and Pramod B. Khedekar. "Quinoline as TRPV1 Antagonists: A New Approach against Inflammation." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 782–88. http://dx.doi.org/10.22270/jddt.v9i4-s.3414.

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Inflammation is the first response of the immune system to harmful stimuli such as infection or irritation, consists of a cascade of biochemical events that propagates and matures the inflammatory response. Number of anti-inflammatory drugs are available for treatment of acute and chronic inflammation. Many anti-inflammatory drugs cause adverse side effects. The quinoline class of compounds are important for searching the safe and effective anti-inflammatory drugs. These drugs are classified based on the number of substituents present on the quinoline ring or compounds containing a quinoline r

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Abelt, Christopher, Ian Day, Junkai Zhao, and Robert Pike. "Fluorescence of Half-Twisted 10-Acyl-1-methyltetrahydrobenzoquinolines." Molecules 29, no. 13 (2024): 3016. http://dx.doi.org/10.3390/molecules29133016.

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The steric interference of proximal dialkyl amino and acyl groups at the peri (1,8) positions of naphthalene affects the intramolecular charge transfer fluorescence. Previous studies indicate that acyl and freely rotating dimethyl amino groups twist toward coplanarity with the naphthalene ring in the excited state. The present study examines the effect of constraining the amino group in a ring. The photophysical properties of 2,2-dimethyl-1-(1-methyl-1,2,3,4-tetrahydrobenzo[h]quinolin-10-yl)propan-1-one (4), ethyl 1-methyl-1,2,3,4-tetrahydrobenzo[h]quinoline-10-carboxylate (5), and 1-methyl-1,

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Book chapters on the topic "Quinoline ring derivatives"

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Sun, Xiao Hui, Jian Qing Guan, Jian Jun Tan, Chang Liu, and Cun Xin Wang. "Exploring Quinoline Ring Derivatives as Potent Integrase Inhibitors Using Ligand-based Modeling Studies." In IFMBE Proceedings. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-29305-4_334.

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Johnson, C. D. "Bicyclic compounds containing a pyridine ring; Quinoline and its derivatives." In Second Supplements to the 2nd Edition of Rodd's Chemistry of Carbon Compounds. Elsevier, 1991. http://dx.doi.org/10.1016/b978-044453347-0.50190-7.

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Silva, V. L. M., D. C. G. A. Pinto, C. M. M. dos Santos, and D. H. A. Rocha. "15.4.5 Quinolinones and Related Systems (Update 2022)." In Knowledge Updates 2022/3. Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/sos-sd-115-01218.

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AbstractQuinolinones, of which the quinolin-4(1H)-one ring system can be highlighted, represent an exciting class of nitrogen heterocycles. The quinolinone motif can be found in many natural compounds and approved drugs for several diseases. This chapter is a comprehensive survey of the methods for the synthesis of quinolin-2(1H)-ones, quinolin-4(1H)-ones, and their thio- and amino derivatives, and is an update to the previous Science of Synthesis chapter (Section 15.4), covering the period between 2003 and 2020.

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D. Adesina, Adebimpe. "The Chemistry of Benzo and Carbocyclic Derivatives of Pyridine." In Exploring Chemistry with Pyridine Derivatives [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.108127.

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The chemistry of pyridine and its derivatives is of considerable importance in the synthesis of intermediates leading to biologically active compounds and novel materials. Generally, derivatives of pyridine are stable and relatively unreactive but can be attacked by electrophiles at ring nitrogen and certain carbon atoms. Pyridines undergo radical substitution reactions preferentially at the 2-position. Simple pyridines and their benzo derivatives are weak bases that form salts with strong acids. Various Lewis acids form complexes with pyridine and its benzo derivatives. The quaternization of

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Conference papers on the topic "Quinoline ring derivatives"

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Christie, D. J., H. Diaz-Arauzo, and J. M. Cook. "REACTIONS OF DRUG-DEPENDENT ANTIBODIES WITH METABOLITES OF QUININE (Qn) AND QUINIDINE (Qd)." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644578.

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In many cases of drug-induced immunologic thrombocytopenia (DITP), a metabolite, rather than the native drug, is suspected of provoking the destructive drug-dependent antibodies (DDAB) responsible for this severe hemorrhagic disorder. However, this has not previously been investigated for Qn- and Qd-DDAB. We report evidence that the native drugs, and not their metabolites, are the provocative agents in Qn and Qd DITP. Reactions of Qn- and Qd-DDAB with platelets were studied with the native drugs and four of their metabolites: the N-oxide and 10,11-diol derivatives (quinuclidine ring modificati

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