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Dissertations / Theses on the topic 'Quinolizines'

Author: Grafiati

Published: 4 June 2021

Last updated: 2 February 2022

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1

Eschenbrenner-Lux, Vincent [Verfasser], Herbert [Akademischer Betreuer] Waldmann, and Frank [Gutachter] Schulz. "Development of cascade reactions to ring fused quinolizines for the synthesis of a natural product inspired compound collection / Vincent Eschenbrenner-Lux. Betreuer: Herbert Waldmann. Gutachter: Frank Schulz." Dortmund : Universitätsbibliothek Dortmund, 2014. http://d-nb.info/1107197309/34.

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2

LE, GOFF-BEVIERE CORINNE. "Pharmacomodulations de quinolones a structure benzo-ij-quinolizine : synthese et activite antibacterienne." Orléans, 1995. http://www.theses.fr/1995ORLE2019.

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L'objectif principal de notre travail sur la pharmacomodulation de quinolones nous a amenes a mettre au point de nouvelles strategies de synthese dans le domaine des quinoleines, a partir d'un synthon unique, la 6-fluoro-2-methylquinoleine conduisant aux precurseurs necessaires a la realisation des quinolones a structure benzoi,jquinolizine. Ainsi, l'utilisation des tetrahydroquinoleines-n-formylees nous a permis par des fonctionnalisations regioselectives d'atteindre des pharmacomodulations donnant acces aux heterocycles imidazo, thiazolo et oxazolo en position 4,5-g sur le noyau quinoleique.

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3

Memetzidis, Georgios. "Pharmacochimie de la tetrahydro-5,6,13,13a 8h-dibenzo (a, g) quinolizine ou berbine." Université Louis Pasteur (Strasbourg) (1971-2008), 1988. http://www.theses.fr/1988STR13159.

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4

Liu, Yannan. "Benzo[c]quinolizine, coumarin, and spiroisoxazolinoproline : lead-based heterocycle design and parallel synthesis /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2002. http://uclibs.org/PID/11984.

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5

Semak, Vladislav. "Synthesis of 1S-ethyl-4-substituted quinolizidines and other potentially bioactive compounds." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/97241.

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Esta Tesis Doctoral se presenta como Compendio de publicaciones. Los capítulos en los que se ha dividido la presente Tesis son los siguientes: Capítulo 1 – parte A: Enantioselective, Protecting Group-Free Synthesis of 1S-Ethyl-4-Substituted Quinolizidines Se ha descrito una síntesis enantioselectiva que no implica grupos protectores para acceder a la quinolizidina clave 6 a partir de la lactama bicíclica derivada de fenilglicinol 1. La adición de un reactivo organometálico a 6 ocurre de manera estereoselectiva para conducir a las quinolizidinas 1S-etil-4-sustituidas 4-epi-207I y 7-9. Sigu

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6

Memetzidis, Georgios. "Pharmacochimie de la tétrahydro-5, 6, 13, 13a 8H-dibenzo [a, g] quinolizine ou berbine." Grenoble 2 : ANRT, 1988. http://catalogue.bnf.fr/ark:/12148/cb37616245j.

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7

MONTHILLER, SOPHIE. "Synthese de 9-oxa-quinolizidines, inhibiteurs potentiels de glycosidases a visee anti-vih." Université Louis Pasteur (Strasbourg) (1971-2008), 1994. http://www.theses.fr/1994STR13138.

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Ce travail traite de la synthese et de l'evaluation biologique de 9-oxaquinolizidines, inhibiteurs potentiels de glycosidases a visee anti-sida. La conception de ces nouveaux inhibiteurs de glycosidases possedant une fonction perhydro-oxazine, a ete realisee en se basant sur le mecanisme d'hydrolyse des glycosides. Le principe des syntheses repose sur l'utilisation d'hexopyranoses comme produit de depart, de meme stereochimie que les composes souhaites. Cette derniere a ete conservee via des reactions d'amination reductrice stereoselectives. Les reactivites observees en serie glucose, mannose

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8

Murphy, Elliot Anthony. "Very strongly σ-donating carbenes and pseudo-amides based on benzo[c]quinolizine : synthesis, properties and use as ligands". Thesis, University of Bristol, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.653076.

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Following DFT calculations, the structure of a new, remotely stabilised, N-heterocyclic carbene, thought to be very strongly a-donating, was proposed. This structure was benzo[c]quinolizin-6-ylidene. Synthesis of the basic scaffold of the benzo[c]quinolizine ring system was performed, giving benzo[c]quinolizin-6-one (2.3a). Several novel 5 and 7 substituted varieties (2.3b-e) were also synthesised, requiring the development of a new route, due to the failure of the initial coupling step when using substituted substrates.

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9

Maloney, Kevin M. (Kevin Matthew). "[4+2] cycloadditions of iminoacetonitriles : a general strategy for the synthesis of quinolizidines, indolizidines, and piperidines." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/39739.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2007.<br>Vita.<br>Includes bibliographical references.<br>Iminoacetonitriles participate as reactive dienophiles in intermolecular and intramolecular Diels-Alder cycloadditions leading to quinolizidines, indolizidines, and piperidines. The resultant a-amino nitrile cycloadducts are versatile synthetic intermediates which can be further elaborated by stereoselective alkylation, reduction, reductive cyclization, and Bruylants reactions. The first part of this thesis describes the full details of our studies on the synthe

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10

Evano, Gwilherm. "Nouvelles utilisations de beta-aminoalcools pour la synthèse d'hétérocycles azotés." Paris 6, 2002. http://www.theses.fr/2002PA066128.

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11

Llanes, Scheila Furtado Braga. "Investigação da atividade biológica de taxóides e Benzo[c]quinolizin-3-onas através de descritores teóricos." [s.n.], 2003. http://repositorio.unicamp.br/jspui/handle/REPOSIP/277639.

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Orientador: Douglas Soares Galvão<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Fisica Gleb Wataghin<br>Made available in DSpace on 2018-09-11T21:00:05Z (GMT). No. of bitstreams: 1 Llanes_ScheilaFurtadoBraga_D.pdf: 1486609 bytes, checksum: 975b9d683860f2c68531081bcd9d855c (MD5) Previous issue date: 2003<br>Resumo: Este trabalho envolveu a investigação da atividade biológica de fármacos por meio de descritores quânticos teóricos e a investigação de um sistema molecular de chaveamento ótico. Em uma primeira parte, apresentamos o estudo realizado para um conjunto de

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12

Vieira, da Cruz Anais. "Synthèse de nouveaux iminosucres et étude de leurs interactions avec des glycosidases." Thesis, Université Grenoble Alpes (ComUE), 2019. http://www.theses.fr/2019GREAV053.

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Les iminosucres constituent une classe de glycomimétiques particulièrement prometteuse pour le traitement de nombreuses maladies, grâce à leur capacité à inhiber et/ou à stabiliser des glycosidases. Ces enzymes, présentes dans tous les organismes vivants, sont impliquées dans différents processus biologiques et sont des cibles thérapeutiques importantes pour le traitement de diverses maladies. Identifier de nouveaux iminosucres sélectifs vis-à-vis d’un type spécifique de glycosidases représente à l’heure actuelle un réel défi scientifique. Le relever est une nécessité pour la mise sur le march

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13

Célanire, Sylvain. "Synthèse de cyclohexa[a]quinolizidines et de cyclohexa[a]indolizidines, analogues tricycliques de 8-azasteroïdes. Nouvelle synthèse d'une cyclopenta[b]pyridinone par des réactions de couplage croisé." Rouen, 1999. http://www.theses.fr/1999ROUES062.

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Notre équipe de recherche s'intéresse depuis une dizaine d'années à la synthèse de nouveaux composes azotés polycycliques de type 8-azasteroïde, inhibiteurs potentiels d'enzymes dans la biosynthèse des stéroïdes. Dans la première partie de ce travail, nous avons développé une nouvelle méthode de synthèse de composés tricycliques à atome d'azote ponté. La (+/-)-10-hydroxy-13-méthylcyclohexa[a]quinolizidine 27 a été synthétisée à partir de la 2-éthylpyridine. L'association de trois étapes clés (métallation latérale-addition nucléophile, annélation de Robinson et N-alkylation intramoléculaire) no

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14

Lamour, Philippe. "Synthèse de pipéridines substituées à activité biologique potentielle." Rouen, 1993. http://www.theses.fr/1993ROUES005.

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Le concept d'intermédiaires de haute énergie dans la biosynthèse de stéroïdes a conduit à l'élaboration d'analogues azotés de ces derniers. Pour étudier les relations structure-activité des molécules potentiellement inhibitrices, des pipéridines et des quinolizidines fonctionnalisées ont été synthetisées. Plusieurs stratégies ont été envisagées et la stéréochimie étudiée. Ce travail décrit également l'étude de plusieurs voies d'accès à des systèmes tricycliques de type azaphénanthrénique saturé dans le but de mimer de façon plus précise le squelette des intermédiaires à structure stéroïdique

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15

Moas, Heloire Valeria. "Conception, synthèse et évaluation de nouveaux ligands antagonistes de récepteurs A2a." Thesis, Lille 2, 2015. http://www.theses.fr/2015LIL2S007/document.

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L’adénosine est un neuromodulateur ubiquitaire impliqué dans différents processus physiologiques et neuroprotecteurs du système nerveux central. Elle agit via quatre sous-types de récepteurs couplés à protéine G (A1, A2a, A2b et A3). Le récepteur A2a (A2aR) est fortement exprimé dans des régions riches en dopamine, avec de fortes concentrations dans la zone du caudate-putamen du cerveau, où elle a un rôle important dans la transmission neuronale et dans le processus dégénératif d’origine extrapyramidale. Ainsi, le blocage du récepteur A2a s’est révélé être une cible prometteuse pour le traitem

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16

Ferroud, Clotilde. "Étude de la réaction de Diels-Adler intra et intermoléculaire sous haute pression : application à la synthèse stéréosélective d'alcaloïdes de l'indole du groupe des yohimbanes." Paris 6, 1986. http://www.theses.fr/1986PA066023.

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Le schéma de synthèse repose sur une unité bicyclique, précurseur direct des unités (d,e) du squelette pentacyclique. Cet intermédiaire est basé sur une réaction de Diels-Alder sous haute pression, utilisant la cycloaddition de diènes de structure donneur-accepteur 1,4 avec une lactone insaturée comme diénophile. La synthèse du système pentacyclique est exposée à partir de cet intermédiaire clé.

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17

Chung-Wen, Ho, and 何仲文. "Synthesis and Applications of Sulfur-substituted Indolizines and Quinolizines." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/09789084940139033076.

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碩士<br>輔仁大學<br>化學系<br>93<br>This thesis mainly studied the [4+2] cycloaddition reactions of C-2 substituted 4-phenylthio-3-sulfolenes 48a and 48b with p-toluenesulfonyl isocyanate (PTSI) to yield 6-membered ring nitrogen compounds 49a and 49b. The tosyl group of 49a and 49b was then cleaved to give compounds 50a and 50b, which under basic condition underwent intramolecular cyclization to yield indolizine 52 and quinolizine 53. We have also carried out some functional group transformations of these bicylic compounds, and have studied the stereochemistry of these reactions.

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18

Chung, Yi-Ching, and 鐘怡青. "Synthetic Applications of Sulfur-substituted Indolizidines and Quinolizidines." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/07842273528507980644.

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碩士<br>輔仁大學<br>化學系<br>96<br>This thesis mainly studied the synthetic transformations of sulfur-substituted indolizidine 51a and quinolizidine 51b. The reaction of compounds 51a and 51b with W-2 type Raney nickel resulted in the cleavage of C-S bond and reduction of the double bond to yield compounds 52a and 52b. Oxidation of compound 51a with mCPBA yielded the sulfone 53a, and cleaving the sulfonyl group with sodium amalgam of 53a gave product 66. Treatment of compound 53a with base led to the elimination product 67. The reaction of compounds 51a and 51b with methylcopper reagents in the presen

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19

Zhang, Jun-Wei, and 張峻瑋. "Synthesis of Sulfone-Substituted Quinolizidines by Cross Metathesis." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/97581825944197071488.

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碩士<br>輔仁大學<br>化學系<br>100<br>This thesis mainly studied the synthesis of quinolizidines by cross metathesis (CM). The reaction of compounds 44 and 50 with lithium triethylborohydride afforded compounds 45 and 51, respectively. Compounds 45 and 51 reacted with BF3·OEt2 and allyltrimethylsilane to give the allyl-substituted products 46a and 52, which were converted to the N-protected products 53 and 56, respectively. Cross metathesis of compound 56 with 1-hexene-3-one in the presence of Grubbs’ catalyst gave the enone 57, which underwent an intramolecular reductive amination to give quinolizidine

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20

JHANG, RUEI-FONG, and 張瑞峰. "Synthesis and Applications ofSulfur- and Methyl-substituted Indolizidines and Quinolizidines." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/07808880798943257173.

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碩士<br>輔仁大學<br>化學系<br>96<br>This thesis mainly studied the [4 + 2] cycloaddition reactions of 3-methyl-4-phenylthio-3-sulfolenes 44 and 45 with p-toluenesulfonyl isocyanate (PTSI) to yield 6-membered ring nitrogen compounds 46a and 47a. The C=C bond of 46a and 47a was moved to conjugation by base, and then the tosyl group was cleaved by Bu3SnH to give compounds 50 and 51, which under basic condition underwent intramolecular cyclization to yield indolizidine 52 and quinolizidine 53. We have also carried out some functional group transformations of these bicylic compounds, and have studied the st

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21

Chiang, Bi-Shan, and 江碧珊. "Synthesis and Applications of Thio-SubstitutedIndolizidines and Quinolizidines by Ring-Closing Metathesis." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/60031739464899090596.

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碩士<br>輔仁大學<br>化學系<br>97<br>This thesis mainly studied the synthesis of thio-substituted indolizidines 58 and 64. The reaction of compound 67 with vinyloxytrimethylsilane and Grubbs’ Ι cat. resulted in the isomerization of the allyl group to yield compound 68. Cleaving the tosyl group with Bu3SnH gave compound 69. Treatment of compound 69 with base and then with different electrophiles yielded compounds 71 and 72. Ring-closing metathesis of compounds 71 and 72 with Grubbs’ cat. gave indolizidines 58 and 64, respectively. Oxidation of compound 58 yieled compound 75. The reaction of compound 58 w

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22

Chen, Kuan-Hua, and 陳冠華. "Synthesis of Sulfone-Substituted Quinolizidines by Ring-Closing Metathesis and Their Applications." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/61805537529380684428.

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碩士<br>輔仁大學<br>化學系<br>98<br>This thesis mainly studied the synthesis and applications of sulfone-substituted quinolizidines 25 and 26. The reaction of compound 20 with lithium triethylborohydride resulted in compound 21. Compound 21 reacted with BF3•OEt2 and allyltrimethylsilane gave compound 22. Treatment of compound 22 with base and then with two different electrophiles yielded compounds 23 and 24. Ring-closing metathesis of compounds 23 and 24 with Grubbs’ II gave quinolizidines 25 and 26, respectively. Hydrogenation of compound 25 produced compounds 27 and 28. The reaction of compound 26 wi

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23

Tse-Ming, Lee, and 李澤明. "Synthetic Studies of Sulfur-substituted Indolizidines and Quinolizidines by Ring-Closing Metathesis." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/10849947983385687012.

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碩士<br>輔仁大學<br>化學系<br>94<br>This thesis has accomplished synthesis of new quinolizidine compounds 13 and 14 by ring-closing metathesis (RCM). Compound 10 was first converted to compound 11 , which underwent RCM to give product 13. On the other hand, compound 1a was alkylated at C-2 to give 3-sulfolene 24, which was reated with PTSI to give the cycloaddition product 26. Upon cleavage of the N-tosyl group, and attachment of the allyl group, the intermediate product 12 also underwent RCM to give quinolizidine 14, but only at much higher temperature and with lower yield. It is proposed that in the

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24

Chen, Po-An, and 陳柏安. "Synthetic Applications of Sulfur-Substituted Quinolizidines. Total Synthesis of Epimyrtine and Lasubine II." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/51833213188960568906.

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碩士<br>輔仁大學<br>化學系<br>98<br>I. Total synthesis of epimyrtine and lasubine II This thesis mainly studied the total synthesis of (±)-epimyrtine (10) and (±)-lasubine II (12). Compound 30 reacted with methylmagnesium bromide and 3,4-dimethoxylphenylmagnesium bromide to produce compounds 29 and 34, respectively. Treatment of compounds 29 and 34 with hydrobromic acid resulted in the hydrolysis of the vinyl sulfide group to afford the corresponding (±)-epimyrtine (10) and ketone 33. Compound 33 has been reported in the literature for the synthesis of (±)-lasubine II (12). II. Synthetic applications

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25

Liang, Chu-Fang, and 梁菊芳. "Synthesis and Applications of Sulfur-substituted Quinolizidines and Pyrido[1,2-a]azepines by Ring-Closing Metathesis." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/08103372825411129135.

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碩士<br>輔仁大學<br>化學系<br>93<br>This thesis is concerned with the [4+2] cycloaddition reactions of 4-(phenylthio)-3-sulfolenes with p-toluenesulfonyl isocyanate. The synthesized 6-membered ring nitrogen compound 3a reacted with Ra-Ni to give the C-S bond cleavage product 48. The [4+2] cycloaddition reactions of C-2 substitued 4-(phenylthio)- 3-sulfolenes 52a and 52b with p-toluenesulfonyl isocyanate yielded 6-membered ring nitrogen compounds 53a and 53b. The tosyl groups of compounds 53a and 53b were removed by radical reaction, and the resulting amides were converted to compounds 55a-c, which con

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