Relevant bibliographies by topics / Quinolone

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Quinolone'

Author: Grafiati
Published: 4 June 2021
Last updated: 26 July 2025

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Journal articles on the topic "Quinolone"

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Shoji, Taku, Mutsumi Takeuchi, Mayumi Uda, et al. "Synthesis of Azuleno[2,1-b]quinolones and Quinolines via Brønsted Acid-Catalyzed Cyclization of 2-Arylaminoazulenes." Molecules 28, no. 15 (2023): 5785. http://dx.doi.org/10.3390/molecules28155785.

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Quinolone and quinoline derivatives are frequently found as substructures in pharmaceutically active compounds. In this paper, we describe a procedure for the synthesis of azuleno[2,1-b]quinolones and quinolines from 2-arylaminoazulene derivatives, which are readily prepared via the aromatic nucleophilic substitution reaction of a 2-chloroazulene derivative with several arylamines. The synthesis of azuleno[2,1-b]quinolones was established by the Brønsted acid-catalyzed intramolecular cyclization of 2-arylaminoazulene derivatives bearing two ester groups at the five-membered ring. The halogenat
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Ehrhardt, A. F., and C. C. Sanders. "Structure-activity studies of quinolone-penems in genetically defined strains of Escherichia coli." Antimicrobial Agents and Chemotherapy 41, no. 11 (1997): 2570–72. http://dx.doi.org/10.1128/aac.41.11.2570.

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Quinolonyl-beta-lactam antimicrobial agents (QLAs) contain quinolones chemically linked to beta-lactams, although the impact of linkage is poorly understood. Genetically defined Escherichia coli strains were used to determine structure-activity characteristics of three quinolone-penem QLAs. Results suggest that the leaving group resulting from beta-lactam hydrolysis may not be free quinolone.
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Kumagai, Y., J. I. Kato, K. Hoshino, T. Akasaka, K. Sato, and H. Ikeda. "Quinolone-resistant mutants of escherichia coli DNA topoisomerase IV parC gene." Antimicrobial Agents and Chemotherapy 40, no. 3 (1996): 710–14. http://dx.doi.org/10.1128/aac.40.3.710.

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Escherichia coli quinolone-resistant strains with mutations of the parC gene, which codes for a subunit of topoisomerase IV, were isolated from a quinolone-resistant gyrA mutant of DNA gyrase. Quinolone-resistant parC mutants were also identified among the quinolone-resistant clinical strains. The parC mutants became susceptible to quinolones by introduction of a parC+ plasmid. Introduction of the multicopy plasmids carrying the quinolone-resistant parC mutant gene resulted in an increase in MICs of quinolones for the parC+ and quinolone-resistant gyrA strain. Nucleotide sequences of the quino
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Noble, Christian G., Faye M. Barnard, and Anthony Maxwell. "Quinolone-DNA Interaction: Sequence-Dependent Binding to Single-Stranded DNA Reflects the Interaction within the Gyrase-DNA Complex." Antimicrobial Agents and Chemotherapy 47, no. 3 (2003): 854–62. http://dx.doi.org/10.1128/aac.47.3.854-862.2003.

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ABSTRACT We have investigated the interaction of quinolones with DNA by a number of methods to establish whether a particular binding mode correlates with quinolone potency. The specificities of the quinolone-mediated DNA cleavage reaction of DNA gyrase were compared for a number of quinolones. Two patterns that depended on the potency of the quinolone were identified. Binding to plasmid DNA was examined by measuring the unwinding of pBR322 by quinolones; no correlation with quinolone potency was observed. Quinolone binding to short DNA oligonucleotides was measured by surface plasmon resonanc
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López, Y., M. Tato, P. Espinal, et al. "In VitroActivity of Ozenoxacin against Quinolone-Susceptible and Quinolone-Resistant Gram-Positive Bacteria." Antimicrobial Agents and Chemotherapy 57, no. 12 (2013): 6389–92. http://dx.doi.org/10.1128/aac.01509-13.

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ABSTRACTIn vitroactivity of ozenoxacin, a novel nonfluorinated topical (L. D. Saravolatz and J. Leggett, Clin. Infect. Dis.37:1210–1215, 2003) quinolone, was compared with the activities of other quinolones against well-characterized quinolone-susceptible and quinolone-resistant Gram-positive bacteria. Ozenoxacin was 3-fold to 321-fold more active than other quinolones. Ozenoxacin could represent a first-in-class nonfluorinated quinolone for the topical treatment of a broad range of dermatological infections.
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Adriaenssens, Niels, Robin Bruyndonckx, Ann Versporten, et al. "Consumption of quinolones in the community, European Union/European Economic Area, 1997–2017." Journal of Antimicrobial Chemotherapy 76, Supplement_2 (2021): ii37—ii44. http://dx.doi.org/10.1093/jac/dkab176.

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Abstract Objectives Data on quinolone consumption in the community were collected from 30 EU/European Economic Area (EEA) countries over two decades. This article reviews temporal trends, seasonal variation, presence of change-points and changes in the composition of main subgroups of quinolones. Methods For the period 1997–2017, data on consumption of quinolones, i.e. ATC group J01M, in the community and aggregated at the level of the active substance, were collected using the WHO ATC/DDD methodology (ATC/DDD index 2019). Consumption was expressed in DDD per 1000 inhabitants per day and in pa
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Horta, Pedro, Marta S. C. Henriques, Elisa M. Brás, et al. "On the ordeal of quinolone preparation via cyclisation of aryl-enamines; synthesis and structure of ethyl 6-methyl-7-iodo-4-(3-iodo-4-methylphenoxy)-quinoline-3-carboxylate." Pure and Applied Chemistry 89, no. 6 (2017): 765–80. http://dx.doi.org/10.1515/pac-2016-1119.

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AbstractRecent studies directed to the design of compounds targeting the bc1 protein complex of Plasmodium falciparum, the parasite responsible for most lethal cases of malaria, identified quinolones (4-oxo-quinolines) with low nanomolar inhibitory activity against both the enzyme and infected erythrocytes. The 4-oxo-quinoline 3-ester chemotype emerged as a possible source of potent bc1 inhibitors, prompting us to expand the library of available analogs for SAR studies and subsequent lead optimization. We now report the synthesis and structural characterization of unexpected ethyl 6-methyl-7-i
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Law, Dennis KS, Michelle Shuel, Sadjia Bekal, Elizabeth Bryce, and Raymond SW Tsang. "Genetic Detection of Quinolone Resistance inHaemophilus parainfluenzae: Mutations in the Quinolone Resistance-Determining Regions ofgyrA andparC." Canadian Journal of Infectious Diseases and Medical Microbiology 21, no. 1 (2010): e20-e22. http://dx.doi.org/10.1155/2010/525919.

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The quinolone resistance-determining regions ofgyrA andparC of both quinolone-sensitive and quinolone-resistantHaemophilus parainfluenzaestrains were amplified and sequenced. Similar toHaemophilus influenzae, resistance to quinolones inH parainfluenzaeis associated with mutations in the quinolone resistance-determining regions of bothgyrA andparC. The present study discusses the importance of this finding.
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McGee, Edoabasi U., Essie Samuel, Bernadett Boronea, Nakoasha Dillard, Madison N. Milby, and Susan J. Lewis. "Quinolone Allergy." Pharmacy 7, no. 3 (2019): 97. http://dx.doi.org/10.3390/pharmacy7030097.

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Quinolones are the second most common antibiotic class associated with drug-induced allergic reactions, but data on quinolone allergy are scarce. This review article discusses the available evidence on quinolone allergy, including prevalence, risk factors, diagnosis, clinical manifestations, cross-reactivity, and management of allergic reactions. Although the incidence of quinolone allergy is still lower than beta-lactams, it has been increasingly reported in recent decades, most likely from its expanded use and the introduction of moxifloxacin. Thorough patient history remains essential in th
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Wang, Xiaoli, Tao Guo, Yunbo Wei, et al. "Determination of Quinolone Antibiotic Residues in Human Serum and Urine Using High-Performance Liquid Chromatography/Tandem Mass Spectrometry." Journal of Analytical Toxicology 43, no. 7 (2019): 579–86. http://dx.doi.org/10.1093/jat/bkz034.

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Abstract Quinolone antibiotic residues may pose potential threat to human health. A rapid and sensitive method was developed for the determination of quinolone residues in human serum and urine. After solid phase extraction (SPE) process, eight quinolone residues were analyzed by high-performance liquid chromatography/tandem mass spectrometry (HPLC-MS/MS) using ciprofloxacin-d8 as the internal standard. The relative standard deviation of intra-day and inter-day precision for the eight quinolones were less than 7.52% and the accuracies ranged from 95.8% to 103% in human serum, and from 94.1% to
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Dissertations / Theses on the topic "Quinolone"

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Meola, Alain. "Les quinolones : étude chimique et pharmacologique, synthèse." Bordeaux 2, 1991. http://www.theses.fr/1991BOR2P090.

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Laurens, Gabrielle. "Quinolones et choc anaphylactique : à propos d'un bilan réalisé au Centre régional de pharmacovigilance du Languedoc-Roussillon." Paris 5, 1992. http://www.theses.fr/1992PA05P158.

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Ballesté, Delpierre Clara Celia. "Quinolone resistance acquisition and impact on virulence in Salmonella enterica: a cost-benefit matter." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/396155.

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Infections due to Salmonella enterica are of great concern worldwide as they represent an important cause of morbidity and mortality. Resistance to antibiotics used to treat salmonellosis has emerged along the years, and thus, the treatment of choice has been changing in order to adapt to the new features of the circulating pathogens causing disease. Currently, fluoroquinolones, mainly represented by ciprofloxacin and ofloxacin, are widely used to treat this kind of infections although other antimicrobial classes as well as new generations of fluoroquinolones are sometimes required when tre
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Parte, Aidan Charles. "4-quinolone antibacterials and temperature." Thesis, University College London (University of London), 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267566.

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Gropper, Achitoov Savion. "Absorption, safety, and tolerability of a topical quinolone (Absorción, seguridad y tolerabilidad de una quinolona tópica)." Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/325687.

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Ozenoxacino es una quinolona no fluorada desarrollada como una crema al 1% para el tratamiento tópico del impétigo en adultos y niños (a partir de 2 meses de edad). Ozenoxacino ha demostrado una potente actividad antibacteriana contra diferentes patógenos involucrados en infecciones bacterianas agudas de la piel y estructuras cutáneas. Los estudios de desarrollo preclínico han demostrado que ozenoxacino muestran un amplio margen de seguridad, falta de efectos adversos generalmente asociados con quinolonas fluoradas, (como fototoxicidad, fotoalergia, potencial de sensibilización y toxicidad de
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Hodgkinson, James Thomas. "The synthesis of Pseudomonas Quinolone Signal analogues and their effects on quinolone signalling in Pseudomonas aeruginosa." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610117.

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Yvon, Jean-François. "Quinolones - fluoroquinolones : évolution de la résistance, apport des nouvelles molécules." Paris 5, 1998. http://www.theses.fr/1998PA05P047.

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Le, Bellego Carl. "Sensibilité "in vitro" de "Chlamydia trachomatis" aux antibiotiques : application aux nouvelles quinolones." Paris 5, 1993. http://www.theses.fr/1993PA05P217.

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Mitelheiser, Sylvain. "DNA gyrase, quinolone drugs and supercoiling mechanism." Thesis, University of East Anglia, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.423811.

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Hallett, Paul. "Studies on DNA gyrase and quinolone drugs." Thesis, University of Leicester, 1990. http://hdl.handle.net/2381/35242.

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A study has been conducted aimed at the generation and characterisation of mutations in the Escherichia coli gyrA gene, resistant to the quinolone group of antibacterial agents. Preliminary studies on quinolone-resistant mutants of strains that over-express the DNA gyrA gene, revealed the over-production of a 60 KDa protein which was partially purified. This 60 KDa protein was found to be similar, but not identical to the E. coli heat shock protein GroEL. The gyrA gene has been recloned in the 8.0 kb plasmid pPH3, which contains the gene under the stringent control of the hybrid tac promoter.
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Books on the topic "Quinolone"

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T, Andriole Vincent, ed. The quinolones. Academic Press, 1988.

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Kuhlmann, J., A. Dalhoff, and H. J. Zeiler, eds. Quinolone Antibacterials. Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-80364-2.

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D, Beermann, Kuhlmann J, Dalhoff Axel, and Zeiler H. J. 1947-, eds. Quinolone antibacterials. Springer, 1998.

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Hooper, David C., and Ethan Rubinstein, eds. Quinolone Antimicrobial Agents. ASM Press, 2003. http://dx.doi.org/10.1128/9781555817817.

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S, Wolfson John, and Hooper David C, eds. Quinolone antimicrobial agents. American Society for Microbiology, 1989.

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T, Andriole Vincent, ed. The quinolones. 3rd ed. Academic Press, 2000.

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Susumu, Mitsuhashi, Daikos George K, and International Congress of Chemotherapy, (14th : 1985 : Kyoto), eds. Ofloxacin: A new quinolone antibacterial agent. University of Tokyo Press, 1986.

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International Telesymposium on Quinolones (1989). Quinolones: Proceedings of an international telesymposium, May 1989. J.R. Prous Science Publishers, 1989.

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Ill.) Physicians & Scientists Publishing Co. (Glenview. Gatifloxacin (Tequin): An advanced generation quinolone for the treatment of selected infectious diseases. Physicians & Scientists Pub., 2000.

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R, Ronald Allan, and Low Don E, eds. Fluoroquinolone antibiotics. Birkhäuser, 2003.

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Book chapters on the topic "Quinolone"

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Mitsuhashi, Susumu, Tsuyoshi Kojima, Noriyuki Nakanishi, et al. "Fluorinated quinolones — new quinolone antimicrobials." In Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Birkhäuser Basel, 1992. http://dx.doi.org/10.1007/978-3-0348-7141-9_1.

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Gooch, Jan W. "Quinolone." In Encyclopedic Dictionary of Polymers. Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_14631.

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Smith, J. T., and H. J. Zeiler. "History and Introduction." In Quinolone Antibacterials. Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-80364-2_1.

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Von Keutz, E., and W. Christ. "Toxicology and Safety Pharmacology of Quinolones." In Quinolone Antibacterials. Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-80364-2_10.

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Kuhlmann, J., H. G. Schaefer, and D. Beermann. "Clinical Pharmacology." In Quinolone Antibacterials. Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-80364-2_11.

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Stahlmann, R., and H. Lode. "Concentration—Effect Relationship of the Fluoroquinolones." In Quinolone Antibacterials. Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-80364-2_12.

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Schacht, P. "Clinical Use of Quinolones." In Quinolone Antibacterials. Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-80364-2_13.

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Segev, S., and E. Rubinstein. "Future Aspects." In Quinolone Antibacterials. Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-80364-2_14.

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Grohe, K. "The Chemistry of the Quinolones: Methods of Synthesizing the Quinolone Ring System." In Quinolone Antibacterials. Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-80364-2_2.

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Petersen, U., and T. Schenke. "The Chemistry of the Quinolones: Chemistry in the Periphery of the Quinolones." In Quinolone Antibacterials. Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-80364-2_3.

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Conference papers on the topic "Quinolone"

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Vera, Jose, William Durnie, Ashwini Chandra, Kevin Ralston, and Richard Woollam. "On the Adsorption Properties of Non-Surfactant Corrosion Inhibitors: Pyridine, Quinoline and Acridine." In CORROSION 2021. AMPP, 2021. https://doi.org/10.5006/c2021-16686.

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Abstract Most of the carbon dioxide (CO2) corrosion inhibition work published has been based on constituents that behave as surfactants (e.g., quaternary amines and imidazolines). For these compounds, a relationship has been found between the concentration for maximum efficiency and the critical micelle concentration (CMC) and, more recently, with the concentration of maximum adsorption (CMA) on platinum. This paper shows how the methodology developed to characterize inhibitors based on their CMA values is still applicable to non-surfactant corrosion inhibitors, which would not show a CMC. The
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Vasilyeva, N. Y., and O. V. Vusovich. "Photoprocesses in quinolone substituted." In International Conference on Atomic and Molecular Pulsed Lasers IV, edited by Victor F. Tarasenko, Georgy V. Mayer, and Gueorgii G. Petrash. SPIE, 2002. http://dx.doi.org/10.1117/12.460126.

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Pillai, Shyamala, Laura Wirpsza, Maxim Kozlov, Salvatore A. E. Marras, Lev Krasnoperov, and Arkady Mustaev. "New cross-linking quinoline and quinolone based luminescent lanthanide probes for sensitive labeling." In SPIE BiOS, edited by Samuel Achilefu and Ramesh Raghavachari. SPIE, 2012. http://dx.doi.org/10.1117/12.921056.

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Andrade, Karine N. de, Amanda R. P. Costa, Rodolfo I. Teixeira, et al. "Photophysical characterization of 3-acyl-4-quinolones." In VIII Simpósio de Estrutura Eletrônica e Dinâmica Molecular. Universidade de Brasília, 2020. http://dx.doi.org/10.21826/viiiseedmol202006.

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4-quinolones derivatives can present fluorescent properties, depending on their substituents and on the chemical environment (e.g., acidic medium), allowing their application as ion sensors. We theoretically evaluated the photophysical properties of previously synthesized 3-acyl-4-quinolones to verify how different substituents (R1=H, NH2 and R2 = OEt, OH, NHPh) affect their absorption profiles and the emission profile of a reference compound, PB3. All DFT and TD-DFT calculations were performed at B3LYP-D3/6-311++G(d,p) level and continuum polarization model for simulated acetonitrile as solve
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Wicke, Lena, and Joachim W. Engels. "Synthesis of 6-substituted quinolone nucleosides as potential HIV integrase inhibitors." In XIVth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2008. http://dx.doi.org/10.1135/css200810473.

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Mücke, MM, S. Rüschenbaum, A. Mayer, et al. "Stool and sputum microbiome during quinolone prophylaxis of spontaneous bacterial peritonitis." In 37. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber. Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0040-1722014.

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Shimizu, Kenichiro, Ken Kikuchi, Masayuki Otsuka, and Keiichi Hiramatsu. "Microbiological Features Of Emergent Increase Of Quinolone-Resistant Strains Of Bordetella Pertussis." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a6086.

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Al-Amiery, Ahmed, Mahdi Radi, and Redha AL-Bayati. "Synthesis, spectroscopic and antimicrobial studies of transition metal complexes of N-amino quinolone derivatives." In The 14th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2010. http://dx.doi.org/10.3390/ecsoc-14-00435.

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Conway, Ruairi, Seamus Cook, Cassandra Malone, Mohammed Osman Hassan-Ibrahim, and Suneeta Soni. "P619 Macrolide and quinolone resistance inmycoplasma genitalium: data from a UK sexual health clinic." In Abstracts for the STI & HIV World Congress (Joint Meeting of the 23rd ISSTDR and 20th IUSTI), July 14–17, 2019, Vancouver, Canada. BMJ Publishing Group Ltd, 2019. http://dx.doi.org/10.1136/sextrans-2019-sti.687.

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González, A., R. González, and M. A. Ferrús. "Antimicrobial susceptibility and quinolone resistance mechanism of Arcobacter butzleri isolates from sewage samples in Spain." In MICROBES IN APPLIED RESEARCH - Current Advances and Challenges. WORLD SCIENTIFIC, 2012. http://dx.doi.org/10.1142/9789814405041_0100.

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Reports on the topic "Quinolone"

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Steele, W., and R. Chirico. Thermodynamics of the hydrodenitrogenation of quinoline. Office of Scientific and Technical Information (OSTI), 1990. http://dx.doi.org/10.2172/6958305.

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Gunsaru, Bornface. Simplified Reversed Chloroquines to Overcome Malaria Resistance to Quinoline-based Drugs. Portland State University Library, 2000. http://dx.doi.org/10.15760/etd.400.

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Wang, Hong, Eric Wolfe, Edgar Lara-Curzio, Marco Martinez, and Tracie Lowe. Study on Electrostatic Separation of Quinoline Insolubles from Coal Tar Pitch. Office of Scientific and Technical Information (OSTI), 2023. http://dx.doi.org/10.2172/1960688.

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Steele, W., S. Knipmeyer, and R. Chirico. Critical property and high-temperature heat-capacity measurements on quinoline and 5,6,7,8-tetrahydroquinoline. Office of Scientific and Technical Information (OSTI), 1990. http://dx.doi.org/10.2172/6957875.

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ลีพิพัฒน์ไพบูลย์, ณัฐชนัญ, ธรรมนูญ หนูจักร, ศิริพัสตร์ ไชยันต์, ม.ล., ลักษณา ดูบาส та มนพิชา ศรีสะอาด. โครงการนำร่องการพัฒนาเทคนิคการตรวจวิเคราะห์สารเติมแต่ง สารปนเปื้อน สารตกค้าง สารสำคัญในอาหารและผลิตผลการเกษตร : รายงานการวิจัย. ภาควิชาเคมี คณะวิทยาศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย, 2013. https://doi.org/10.58837/chula.res.2013.44.

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งานวิจัยนี้เป็นโครงงานวิจัยนำร่องสู่โครงการหลักมหาวิทยาลัยวิจัย คลัสเตอร์อาหารและน้ำหัวข้อการพัฒนาเทคนิคการตรวจวิเคราะห์สารเติมแต่ง สารปนเปื้อน สารตกค้าง สาระสำคัญในอาหารและผลิตผลการเกษตร นำเสนอการตรวจวัดสารยาสัตว์ตกค้างในเนื้อไก่การวิเคราะห์สารปนเปื้อนเหล่านี้ในสินค้าปศุสัตว์ทั้งสิ้น 24 ชนิด จาก 8 กลุ่มหลักได้แก่ กลุ่ม aminoglycosides 3 ชนิด, กลุ่ม β-lactam 3 ชนิด, กลุ่ม lincosamides 2 ชนิด, กลุ่ม macrolides 4 ชนิด, กลุ่ม quinolones 4 ชนิด, กลุ่ม sulfonamides 4 ชนิด, กลุ่ม tetracyclines 3 ชนิดและ amprollium โดยสกัดด้วยตัวทำละลายและวิเคราะห์ด้วยเทคนิคลิควิดโครมาโทกราฟีแทนเดมแมสสเปกโทรเมทรี โดย
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6

Chaudhuri, Shubham, Pinelopi Goldberg, and Panle Jia. Estimating the Effects of Global Patent Protection in Pharmaceuticals: A Case Study of Quinolones in India. National Bureau of Economic Research, 2003. http://dx.doi.org/10.3386/w10159.

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Bradshaw, Jerald S., Guoping Xue, Xian X. Zhang, Paul B. Savage, and Krzysztof E. Krakowiak. Bis-(quinolin-8-ylmethyl)-substituted Diaza-18-crown-6: Synthesis and Metal Ion Complexation Properties. Defense Technical Information Center, 2000. http://dx.doi.org/10.21236/ada375274.

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