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Dissertations / Theses on the topic 'Quinolone'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Meola, Alain. "Les quinolones : étude chimique et pharmacologique, synthèse." Bordeaux 2, 1991. http://www.theses.fr/1991BOR2P090.

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2

Laurens, Gabrielle. "Quinolones et choc anaphylactique : à propos d'un bilan réalisé au Centre régional de pharmacovigilance du Languedoc-Roussillon." Paris 5, 1992. http://www.theses.fr/1992PA05P158.

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3

Ballesté, Delpierre Clara Celia. "Quinolone resistance acquisition and impact on virulence in Salmonella enterica: a cost-benefit matter." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/396155.

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Infections due to Salmonella enterica are of great concern worldwide as they represent an important cause of morbidity and mortality. Resistance to antibiotics used to treat salmonellosis has emerged along the years, and thus, the treatment of choice has been changing in order to adapt to the new features of the circulating pathogens causing disease. Currently, fluoroquinolones, mainly represented by ciprofloxacin and ofloxacin, are widely used to treat this kind of infections although other antimicrobial classes as well as new generations of fluoroquinolones are sometimes required when tre

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4

Parte, Aidan Charles. "4-quinolone antibacterials and temperature." Thesis, University College London (University of London), 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267566.

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5

Gropper, Achitoov Savion. "Absorption, safety, and tolerability of a topical quinolone (Absorción, seguridad y tolerabilidad de una quinolona tópica)." Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/325687.

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Ozenoxacino es una quinolona no fluorada desarrollada como una crema al 1% para el tratamiento tópico del impétigo en adultos y niños (a partir de 2 meses de edad). Ozenoxacino ha demostrado una potente actividad antibacteriana contra diferentes patógenos involucrados en infecciones bacterianas agudas de la piel y estructuras cutáneas. Los estudios de desarrollo preclínico han demostrado que ozenoxacino muestran un amplio margen de seguridad, falta de efectos adversos generalmente asociados con quinolonas fluoradas, (como fototoxicidad, fotoalergia, potencial de sensibilización y toxicidad de

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6

Hodgkinson, James Thomas. "The synthesis of Pseudomonas Quinolone Signal analogues and their effects on quinolone signalling in Pseudomonas aeruginosa." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610117.

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7

Yvon, Jean-François. "Quinolones - fluoroquinolones : évolution de la résistance, apport des nouvelles molécules." Paris 5, 1998. http://www.theses.fr/1998PA05P047.

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8

Le, Bellego Carl. "Sensibilité "in vitro" de "Chlamydia trachomatis" aux antibiotiques : application aux nouvelles quinolones." Paris 5, 1993. http://www.theses.fr/1993PA05P217.

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9

Mitelheiser, Sylvain. "DNA gyrase, quinolone drugs and supercoiling mechanism." Thesis, University of East Anglia, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.423811.

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10

Hallett, Paul. "Studies on DNA gyrase and quinolone drugs." Thesis, University of Leicester, 1990. http://hdl.handle.net/2381/35242.

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A study has been conducted aimed at the generation and characterisation of mutations in the Escherichia coli gyrA gene, resistant to the quinolone group of antibacterial agents. Preliminary studies on quinolone-resistant mutants of strains that over-express the DNA gyrA gene, revealed the over-production of a 60 KDa protein which was partially purified. This 60 KDa protein was found to be similar, but not identical to the E. coli heat shock protein GroEL. The gyrA gene has been recloned in the 8.0 kb plasmid pPH3, which contains the gene under the stringent control of the hybrid tac promoter.

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11

Boughougal, Amina. "Synthèse et caractérisation de composés de coordination antimicrobiens." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1260.

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Le développement de composés de coordination biologiquement actifs (antimicrobiens, les anti-inflammatoires, les antifongiques, les anti-oxydants et les anticancéreux) est un domaine de la chimie inorganique en évolution rapide, susceptible d'avoir un impact direct sur l'amélioration de la qualité de la vie. Les complexes métallo-antibiotique tirent parti de l'effet synergique pour aboutir à une activité pharmacologique améliorée. La reconnaissance du rôle des ions métalliques dans les systèmes biologiques et dans le traitement de diverses maladies attire l'attention sur les avantages d'étudie

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12

Ilangovan, Aravindan. "Structural studies of Pseudomonas quinolone signal regulator PqsR." Thesis, University of Nottingham, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.580285.

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Pseudomonas aeruginosa is an opportunistic pathogen with a wide host range. It causes serious infection in cyctic fibrosis patients and patients with suppressed immunity. Most of the virulence and adaptational characters of this pathogen are controlled by quorum sensing. Quorum sensing in P. aeruginosa has two types of system, the first quorum sensing system is facilitated by N-acyl homoserine lactones which is further constituted by two system las and rhl system. The second type of quorum sensing system is facilitated by alkyl quinolones (AQ) and thus called the AQ signalling system. The AQ q

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13

Willmott, Christopher John Rowan. "The interaction of quinolone antibacterials with DNA gyrase." Thesis, University of Leicester, 1993. http://hdl.handle.net/2381/35181.

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Quinolone drags are a clinically significant family of antibacterial compounds that are known to affect the activity of DNA gyrase, an essential bacterial enzyme involved in controlling the topological state of DNA, Gyrase holoenzyme, a complex of two A and two B subunits, can introduce negative supercoils into DNA using energy derived from the hydrolysis of ATP. Although addition of quinolones rapidly inhibits the supercoiling activity of gyrase, it was found that quinolone-dependent DNA cleavage was a slow process, leading to the suggestion that there may be two levels of interaction between

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14

MacDonald, Alasdair Arthur. "Synthesis of quinolone antibiotics by Diversomer™ technology." Thesis, University of Edinburgh, 1995. http://hdl.handle.net/1842/11075.

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The generation of chemical diversity by the parallel synthesis of potential drug candidates has been demonstrated by Parke-Davis' DIVERSOMER Technology. This technology combines solid phase organic synthesis, (SPOS), miniaturization, automation, integration and custom equipment to generate "libraries" of discrete compounds. The research programme involved a detailed analysis of the synthesis of the quinolones, a well-known class of antibacterial agents of which over 6000 compounds are known to date. A solution phase synthesis was developed which was compatible with solid phase reaction conditi

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15

Hayes, Michelle. "β-lactam and quinolone resistance in Aeromonas spp". Thesis, University of Edinburgh, 1995. http://hdl.handle.net/1842/20558.

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The majority of <I>Aeromonas</I> spp. are innately resistant to ampicillin, therefore the aim of this thesis was to examine the resistance mechanism of <I>A.salmonicida</I> subspp. <I>achromogenes</I> and <I>A.hydrophila</I> to β-lactam antibiotics. Previous researchers had revealed the presence of two β-lactamases in the motile <I>Aeromonas</I> spp., a penicillinase with carbapenemase activity and a cephalosporinase. However, it was demonstrated in this thesis, that these β-lactamases had not been purified completely and that three β-lactamases could be purified from <I>A.salmonicida</I> subs

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16

Lenz, Jörn-Benjamin [Verfasser], and Peter [Akademischer Betreuer] Heisig. "The ternary gyrase-DNA-quinolone complex : from molecular modelling to understanding quinolone action and resistance / Jörn-Benjamin Lenz. Betreuer: Peter Heisig." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2011. http://d-nb.info/102038350X/34.

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17

Allali, Nourredine. "Analyse du rôle des gènes chromosomiques tldD et tldE dans le système poison/antidote ccd et dans la maturation de la microcine B17." Doctoral thesis, Universite Libre de Bruxelles, 2002. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211343.

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18

Robaux, Hubert. "Contribution à l'étude du mécanisme d'action des quinolones : implication de métaux (magnésium et cuivre) dans la formation de chélates avec une base purique ou la tyrosine et dans l'interaction avec les topoisomérases." Nancy 1, 1990. http://www.theses.fr/1990NAN10554.

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19

Peyramaure, Elisabeth. "Distribution de trois classes d'antibiotiques dans l'organisme : les macrolides, les quinolones et les céphalosporines." Paris 5, 1991. http://www.theses.fr/1991PA05P193.

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20

Sousa, Rafaela Rogério Floriano de. "Pesquisa de genes de resistência a quinolonas em bacilos Gram negativos de origem clínica e ambiental." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/6/6135/tde-27032014-091736/.

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Introdução. Quinolonas são antimicrobianos sintéticos que inibem as enzimas DNA-girase e topoisomerase IV resultando na morte bacteriana. São altamente eficazes no tratamento de infecções bacterianas, especialmente causadas por bactérias Gram negativas, e portanto amplamente utilizados na medicina humana e veterinária, na qual também são empregados como profiláticos. Porém, o uso indiscriminado e inadequado levou ao aumento de bactérias resistentes a estes compostos. Esta resistência pode ocorrer devido a mutações nas enzimas DNA-girase e topoisomerase IV, e também por genes contidos em plasmí

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21

Minarini, Luciene Andrade da Rocha. "Estudo dos mecanismos de resistências às quinolonas em enterobactérias isoladas de alguns estados brasileiros." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/60/60135/tde-01042009-103754/.

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Este estudo foi elaborado com o objetivo de elucidar os mecanismos de resistência às quinolonas presentes em enterobactérias isoladas de pacientes de duas regiões metropolitanas brasileiras. Foram avaliadas possíveis alterações nas proteínas relacionadas com o sítio de ação das quinolonas, bem como a presença de plasmídeos e integrons que carregam determinantes gênicos que codificam resistência às quinolonas. A associação destes com mecanismos plasmideais de resistência aos antibióticos -lactâmicos também foi analisada. Foram avaliadas 257 enterobactérias resistentes ao ácido nalidíxico isolad

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22

Murphy, Steven Michael. "Novel aspects of the Wittig reaction." Thesis, Northumbria University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245286.

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23

TAUPIN, SCHWETTERLE MARTINE. "Etude de pharmacovigilance de quatre fluoroquinolones : pefloxacine, norfloxacine, ofloxacine, ciprofloxacine." Reims, 1990. http://www.theses.fr/1990REIMM067.

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24

Eftekharzadeh, Shirin 1967. "The attachment of quinolone based antibiotics to metallic biomaterials." Thesis, The University of Arizona, 1993. http://hdl.handle.net/10150/278347.

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A simple and effective technique for the deposition of ciprofloxacin HCl salt onto pore coated Ti-6Al-4V alloy rods has been investigated for the prevention of infection in orthopedic applications. This technique involves the electrophoretic deposition of negatively charged ciprofloxacin particles as well as the precipitation of ciprofloxacin anions on positively biased rods. Experimental variables such as applied voltage, coating time, and pH of the antibiotic solution have been investigated in terms of the amount of deposited antibiotic, the morphology of antibiotic coating, the rate of rele

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25

Brown, Janice C. "Molecular interactions between DNA gyrase and the quinolone antibacterials." Thesis, University of Edinburgh, 1997. http://hdl.handle.net/1842/21651.

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DNA gyrase is an essential bacterial topoisomerase with a central role in many cellular processes. Its lack of homology to eukaryotic topoisomerases has been the basis of its role as an important drug target. The quinolone antibacterials have previously been shown to "poison" DNA gyrase of <I>Escherichia coli,</I> resulting in rapid bacterial cell death by a pathway which has been a subject of controversy. Following on from the finding that the complex of quinolone and gyrase on DNA results in truncated mRNAs <I>in vitro, </I>the results presented in this thesis show that <I>in vivo,</I> the a

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26

Gunn, Mary Esther. "A modular catalytic approach towards pyridine and quinolone synthesis." Thesis, University of Leeds, 2013. http://etheses.whiterose.ac.uk/4959/.

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N-Containing heterocycles such as substituted pyridines and 2-quinolones are commonly found in drugs and agrochemicals; however, classical methods towards their synthesis often lead to limited substitution patterns. We recently described the first examples of the organocatalytic intramolecular aza-Wittig reaction in the synthesis of azoles and azines from isocyanates. The work described herein is divided into three chapters detailing attempts to expand the scope of the use of isocyanates in heterocycle synthesis. The first chapter describes the development of multicomponent synthesis of substi

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27

Padovanni, Madeleine Toran. "Pneumopathies alvéolo-interstitielles infectieuses et fluoroquinolones à propos de 46 observations." Montpellier 1, 1990. http://www.theses.fr/1990MON11021.

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28

Coulibaly, Songuigama. "Synthèse et activité antituberculeuse de quelques dérivés de la 1,10-phénanthrolinone." Thesis, Normandie, 2018. http://www.theses.fr/2018NORMC407/document.

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La tuberculose est une infection humaine cosmopolite à transmission pulmonaire causée par Mycobactérium tuberculosis. Elle représente l'une des principales causes de mortalité dans le monde. La prise en charge thérapeutique de cette maladie est confrontée aujourd’hui à une forte pharmacorésistance des bacilles à la plupart des médicaments antituberculeux habituellement indiqués. Face à cette situation la recherche de nouvelles molécules plus efficaces échappant au phénomène de pharmacorésistance est encouragée par l'OMS. C'est dans ce contexte que nous avons conçu des dérivés de la 1,10-phénan

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29

VAUGIN-BOULANGER, VERONIQUE. "Effets indesirables des nouvelles quinolones." Clermont-Ferrand 1, 1989. http://www.theses.fr/1989CLF13005.

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30

Jackson, Andrew Edward. "A novel approach to #beta#-lactam and quinolone antibacterial agents." Thesis, University of Sunderland, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242127.

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The f)-lactam or azetidinone 4-membered heterocyclic nng system has been synthesised by many different synthetic strategies and these are well documented in the literature. Many of these strategies give substituted azetidinone rings displaying defined stereochemistry which are used as the building block for many modern day antibiotics. It was therefore intended to pursue a method of azetidinone ring formation using cheap and readily available starting materials employing a [2+2] cycloaddition reaction which, according to the literature, had only a few examples and was seen to be an area ripe f

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31

Critchlow, Susan Elizabeth. "The molecular basis of quinolone drug action on DNA gyrase." Thesis, University of Leicester, 1996. http://hdl.handle.net/2381/35198.

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Quinolones are a clinically-useful class of antibacterial agents known to target DNA gyrase, a bacterial type II topoisomerase. Gyrase is unique among topoisomerases in its ability to introduce negative supercoils into DNA using the energy derived from ATP hydrolysis. The active enzyme is composed of two GyrA and two GyrB subunits, forming an A2B2 tetramer of molecular weight 374 kDa. The mechanism of supercoiling by gyrase involves the ATP-driven passage of one segment of DNA through a gyrase-stabilised double-stranded break in another. Tyrosine 122 of E. coli GyrA becomes covalently attached

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32

Thorburn, Christine Elaine. "The effect of pharmacokinetics on the development of bacterial resistance to antibiotics." Thesis, University of East London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359992.

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33

Fochesatto, Cíntia. "Caracterização química e avaliação in vitro da atividade antimicrobiana de complexos de 99m Tc-ciprofloxacino e 99m Tc-pefloxacino." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2008. http://hdl.handle.net/10183/13156.

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A diferenciação entre processos infecciosos e inflamatórios representa um grande desafio na área de diagnóstico. A complexação do antimicrobiano ciprofloxacino (CIP) com o tecnécio (99mTc-CIP) vem sendo estudada com objetivo de desenvolver um radiofármaco com alta especificidade no diagnóstico de infecções, baseado em seu amplo espectro de atividade antibacteriana. O mecanismo de ação do fármaco consiste na ligação deste com a enzima ADN-girase da bactéria, permitindo sua ligação à bactéria ativa e a obtenção de imagens devido a fótons emitidos pelo 99mTc. Tendo em vista que o local de formaçã

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34

Vales, Magali. "Systèmes photochromiques en série quinolone : conception, synthèse, étude des propriétés photochromiques." Aix-Marseille 2, 2002. http://www.theses.fr/2002AIX22058.

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35

Oh, Herin. "Quinolone resistance in Bacteroides fragilis and Pseudomonas aeruginosa, two opportunistic pathogens /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-498-4.

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36

Smith, Ashley B. Thornton. "Epidemiology and quinolone-susceptibilities of Salmonella and Campylobacter in feedlot cattle." Diss., Kansas State University, 2017. http://hdl.handle.net/2097/35391.

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Doctor of Philosophy<br>Department of Diagnostic Medicine/Pathobiology<br>David G. Renter<br>Salmonella and Campylobacter are two leading causes of human foodborne disease. Cattle can asymptomatically shed these organisms in their feces. Fluoroquinolones are antimicrobials used to treat both humans and animals. With concerns over antimicrobial resistance, antimicrobial use in livestock has become scrutinized. Data on prevalence and susceptibility of Salmonella and Campylobacter in feedlot cattle, particularly those exposed to fluoroquinolones, are sparse. The purpose of the research describe

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37

Feron, Thierry. "Syntheses en serie indolique." Reims, 1997. http://www.theses.fr/1997REIMP202.

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38

Prothiwa, Michaela [Verfasser]. "Inhibition of Quinolone Biosynthesis in Pseudomonas aerugionsa and Burkholderia species / Michaela Prothiwa." Konstanz : KOPS Universität Konstanz, 2019. http://d-nb.info/1237222036/34.

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39

Kang, Manjinder S. "Interaction of quinolone antibiotics with the human intestinal CACO-2 cell model." Thesis, Aston University, 2001. http://publications.aston.ac.uk/12354/.

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The transport of a group of quinolone antibiotics across the human intestinal model, Caco-2 cells, was investigated. It was found that the transport of the quinolones generally correlated with the lipophilicity of the compounds, indicating the passive diffusional transcellular processes were involved. However, it was observed that the transport in both directions apical-to-basolateral and basolateral-to-apical was not equivalent, and polarised transport occurred. For all the quinolones studied except, BMS-284756-01, it was found that the basolateral-to-apical transport was significantly greate

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40

González, Pinacho Daniel. "Estrategias Analíticas basadas en el Diseño de Inmunoreactivos de Clase para el Control de Residuos de Quinolonas en Leche." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/301432.

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La presencia de contaminantes y residuos químicos en los alimentos es un problema que actualmente genera gran preocupación, ya que presenta importantes implicaciones para la salud y la seguridad pública. En este sentido, el uso indiscriminado, inadecuado y/o fraudulento de fármacos veterinarios puede dar lugar a la presencia de residuos de los mismos en los alimentos de origen animal, entrando de esta forma en la cadena trófica y ocasionando riesgos para la salud. Por otro lado, este tipo de residuos puede ser liberado al medioambiente directamente o indirectamente a través de la utilización d

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41

Salvaggio, Flavia. "Synthesis of biologically active quinolone natural products extracted from the actinomycete Pseudonocardia sp. CL38489." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648770.

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42

CHATELUT, LASSALLE MARTINE. "Mise au point d'une technique de bioluminescence pour l'etude de la cinetique de bactericidie de beta-lactamines et quinolones sur pseudomonas aeruginosa." Toulouse 3, 1993. http://www.theses.fr/1993TOU31705.

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43

Truong, Que Chi. "Resistance aux quinolones par modification de la sous-unite a de la gyrase : role de ces mutations dans la dominance de variants de gyra." Paris 11, 1996. http://www.theses.fr/1996PA114842.

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44

Ouabdesselam, Saliha. "Aspects genetiques de la resistance aux quinolones chez les bacteries a gram-negatif." Paris 11, 1997. http://www.theses.fr/1997PA114826.

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45

GAMBART, MARIE-ODILE. "Interet des fluoroquinolones dans le traitement des infections osteo-articulaires ; a propos de 29 observations traitees par ofloxacine." Lille 2, 1989. http://www.theses.fr/1989LIL2M132.

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46

Xiong, Xiaoli. "Structural and biochemical studies of the quinolone resistance protein Qnr from Aeromonas hydrophila." Thesis, University of Bristol, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540907.

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47

Sreedharan, Santha. "Quinolone resistance in Staphylococcus : role of DNA gyrase and the norA efflux pump." Thesis, St George's, University of London, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267505.

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48

Ardo, Sandy. "Dégradation oxydative d'une quinolone par la nano-magnétite via l'interaction Fe(II) / O2." Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066410/document.

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La magnétite, Fe3O4, est un oxyde de fer naturel à valence mixte Fe(II-III), qui sous sa forme nanométrique, a un fort potentiel d’applications technologiques dans des domaines allant de la biomédecine au traitement des eaux. Les nano-magnétites sont très efficaces pour l’adsorption ainsi que la réduction et l’oxydation de divers polluants environnementaux. Elles peuvent catalyser l’oxydation de type Fenton hétérogène induisant une dégradation efficace des polluants organiques et ceci dans un large domaine de pH. Cependant, les mécanismes impliqués restent mal connus. L’objectif principal de c

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49

Ardo, Sandy. "Dégradation oxydative d'une quinolone par la nano-magnétite via l'interaction Fe(II) / O2." Electronic Thesis or Diss., Paris 6, 2014. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2014PA066410.pdf.

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La magnétite, Fe3O4, est un oxyde de fer naturel à valence mixte Fe(II-III), qui sous sa forme nanométrique, a un fort potentiel d’applications technologiques dans des domaines allant de la biomédecine au traitement des eaux. Les nano-magnétites sont très efficaces pour l’adsorption ainsi que la réduction et l’oxydation de divers polluants environnementaux. Elles peuvent catalyser l’oxydation de type Fenton hétérogène induisant une dégradation efficace des polluants organiques et ceci dans un large domaine de pH. Cependant, les mécanismes impliqués restent mal connus. L’objectif principal de c

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50

Fiorucci, Sandrine. "Caractérisation cellulaire et moléculaire de l'activité de dérivés de 2-aryl-3-quinolone, une famille de petites molécules antagonistes de la queue cytoplasmique des intégrines." Thesis, Grenoble, 2013. http://www.theses.fr/2013GRENV058/document.

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Les flavonoïdes sont étudiés depuis des années pour leurs propriétés préventives et leur potentiel comme agents thérapeutiques. Plusieurs mécanismes pourraient intervenir dans leur activité anti-cancéreuse dont une inhibition de l'adhérence et de l'étalement cellulaire et une inhibition des propriétés invasives des cellules cancéreuses. Les dérivés de 3-aryl-2-quinolones sont structurellement proches des flavonoïdes et ont été caractérisés comme étant des composés anti-migratoires (Joseph et Al., J.Med.Chem, 2002). Comme la migration cellulaire est hautement dépendante des structures adhésives

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