Relevant bibliographies by topics / Quinone Physiological effect

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Academic literature on the topic 'Quinone Physiological effect'

Author: Grafiati
Published: 4 June 2021
Last updated: 30 January 2023

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Journal articles on the topic "Quinone Physiological effect"

1

Wallin, R. "Vitamin K antagonism of coumarin anticoagulation. A dehydrogenase pathway in rat liver is responsible for the antagonistic effect." Biochemical Journal 236, no. 3 (June 15, 1986): 685–93. http://dx.doi.org/10.1042/bj2360685.

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In the liver, it appears that there are two different pathways for vitamin K reduction. One pathway is irreversibly inhibited by coumarin anticoagulant drugs. The other pathway has been shown in the present study to be composed of enzymes that are not effected by physiological ‘in vivo’ concentrations of these drugs. This pathway appears to be responsible for the antidotal effect of vitamin K in overcoming coumarin poisoning. In rat liver the pathway has been shown to be composed of DT-diaphorase (EC.1.6.99.2) and a microsomal dehydrogenase(s). The activity of the microsomal dehydrogenase(s) was 3.6-fold higher with NADH than with NADPH present in the test system. It appears that this enzyme is the physiologically important enzyme in the pathway. In contrast with DT-diaphorase, this enzyme(s) is shown to be tightly associated with the mirosomal membrane. The enzyme(s) is not identical with either of the quinone-reducing enzymes cytochrome P-450 reductase or cytochrome-b5 reductase. Our data thus postulate the existence of an as-yet-unidentified microsomal dehydrogenase that appears to have an important function in the pathway.
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2

Voronin, Mikhail V., Yulia V. Vakhitova, Inna P. Tsypysheva, Dmitry O. Tsypyshev, Inna V. Rybina, Rustam D. Kurbanov, Elena V. Abramova, and Sergei B. Seredenin. "Involvement of Chaperone Sigma1R in the Anxiolytic Effect of Fabomotizole." International Journal of Molecular Sciences 22, no. 11 (May 21, 2021): 5455. http://dx.doi.org/10.3390/ijms22115455.

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Sigma-1 receptor (chaperone Sigma1R) is an intracellular protein with chaperone functions, which is expressed in various organs, including the brain. Sigma1R participates in the regulation of physiological mechanisms of anxiety (Su, T. P. et al., 2016) and reactions to emotional stress (Hayashi, T., 2015). In 2006, fabomotizole (ethoxy-2-[2-(morpholino)-ethylthio]benzimidazole dihydrochloride) was registered in Russia as an anxiolytic (Seredenin S. and Voronin M., 2009). The molecular targets of fabomotizole are Sigma1R, NRH: quinone reductase 2 (NQO2), and monoamine oxidase A (MAO-A) (Seredenin S. and Voronin M., 2009). The current study aimed to clarify the dependence of fabomotizole anxiolytic action on its interaction with Sigma1R and perform a docking analysis of fabomotizole interaction with Sigma1R. An elevated plus maze (EPM) test revealed that the anxiolytic-like effect of fabomotizole (2.5 mg/kg i.p.) administered to male BALB/c mice 30 min prior EPM exposition was blocked by Sigma1R antagonists BD-1047 (1.0 mg/kg i.p.) and NE-100 (1.0 mg/kg i.p.) pretreatment. Results of initial in silico study showed that fabomotizole locates in the active center of Sigma1R, reproducing the interactions with the site’s amino acids common for established Sigma1R ligands, with the ΔGbind value closer to that of agonist (+)-pentazocine in the 6DK1 binding site.
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Umezawa, Kiwamu, Kouta Takeda, Takuya Ishida, Naoki Sunagawa, Akiko Makabe, Kazuo Isobe, Keisuke Koba, et al. "A Novel Pyrroloquinoline Quinone-Dependent 2-Keto-d-Glucose Dehydrogenase from Pseudomonas aureofaciens." Journal of Bacteriology 197, no. 8 (February 2, 2015): 1322–29. http://dx.doi.org/10.1128/jb.02376-14.

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A gene encoding an enzyme similar to a pyrroloquinoline quinone (PQQ)-dependent sugar dehydrogenase from filamentous fungi, which belongs to new auxiliary activities (AA) family 12 in the CAZy database, was cloned fromPseudomonas aureofaciens. The deduced amino acid sequence of the cloned enzyme showed only low homology to previously characterized PQQ-dependent enzymes, and multiple-sequence alignment analysis showed that the enzyme lacks one of the three conserved arginine residues that function as PQQ-binding residues in known PQQ-dependent enzymes. The recombinant enzyme was heterologously expressed in anEscherichia coliexpression system for further characterization. The UV-visible (UV-Vis) absorption spectrum of the oxidized form of the holoenzyme, prepared by incubating the apoenzyme with PQQ and CaCl2, revealed a broad peak at approximately 350 nm, indicating that the enzyme binds PQQ. With the addition of 2-keto-d-glucose (2KG) to the holoenzyme solution, a sharp peak appeared at 331 nm, attributed to the reduction of PQQ bound to the enzyme, whereas no effect was observed upon 2KG addition to authentic PQQ. Enzymatic assay showed that the recombinant enzyme specifically reacted with 2KG in the presence of an appropriate electron acceptor, such as 2,6-dichlorophenol indophenol, when PQQ and CaCl2were added.1H nuclear magnetic resonance (1H-NMR) analysis of reaction products revealed 2-keto-d-gluconic acid (2KGA) as the main product, clearly indicating that the recombinant enzyme oxidizes the C-1 position of 2KG. Therefore, the enzyme was identified as a PQQ-dependent 2KG dehydrogenase (Pa2KGDH). Considering the high substrate specificity, the physiological function ofPa2KGDH may be for production of 2KGA.
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4

Kalneniece, Kristīne, Toms Kusiņš, Inga Balode, Līva Mazkalniņa, Kārlis Švirksts, Māra Grūbe, Gunta Kizane, Vasīlijs Bankovskis, Andrejs Grīnbergs, and Olga Muter. "Effect of Isothiocyanates on the Activity of Lactobacillus plantarum Exposed to Irradiation." Key Engineering Materials 850 (June 2020): 219–24. http://dx.doi.org/10.4028/www.scientific.net/kem.850.219.

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Two isothiocyanates, i.e., sulforaphane (SFA) and sulforaphene (SFE), are suggested to be used as an alternative chemopreventive diet. This study was focused on the effect of SFA and SFE on Lactobacillus plantarum, which has been subjected to the irradiation (2-50 Gy). The cultures grown in De Man, Rogosa and Sharpe (MRS) and Tryptone Soya Broth (TSB) were compared in terms of bacteria physiological activity under tested conditions. Broth composition notably influenced the bacteria growth kinetic parameters, as well as culture response to the oxidative stress. Activity of L. plantarum cells after irradiation was evaluated by their dehydrogenase (DHA) and quinone-reductase (QR) activities. The enzyme activity was quantified in living cells. Bacterial cultures obtained in MRS and TSB broth, demonstrated contrasting characteristics in their enzyme activities. The MRS-grown culture did not show any QR activity, whereas the TSB-grown cells showed a non-linear response towards gamma-irradiation with a maximum inhibition being at 10 Gy. Addition of SFA or SFE in concentration of 1 µg/mL to the cultures before irradiation exposure recovered the QR activity from 23% in a non-amended variant up to 102% and 121%, respectively, taking the non-irradiated non-amended variant as 100%.
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5

Cooley, Jason W., and Wim F. J. Vermaas. "Succinate Dehydrogenase and Other Respiratory Pathways in Thylakoid Membranes of Synechocystis sp. Strain PCC 6803: Capacity Comparisons and Physiological Function." Journal of Bacteriology 183, no. 14 (July 15, 2001): 4251–58. http://dx.doi.org/10.1128/jb.183.14.4251-4258.2001.

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ABSTRACT Respiration in cyanobacterial thylakoid membranes is interwoven with photosynthetic processes. We have constructed a range of mutants that are impaired in several combinations of respiratory and photosynthetic electron transport complexes and have examined the relative effects on the redox state of the plastoquinone (PQ) pool by using a quinone electrode. Succinate dehydrogenase has a major effect on the PQ redox poise, as mutants lacking this enzyme showed a much more oxidized PQ pool. Mutants lacking type I and II NAD(P)H dehydrogenases also had more oxidized PQ pools. However, in the mutant lacking type I NADPH dehydrogenase, succinate was essentially absent and effective respiratory electron donation to the PQ pool could be established after addition of 1 mM succinate. Therefore, lack of the type I NADPH dehydrogenase had an indirect effect on the PQ pool redox state. The electron donation capacity of succinate dehydrogenase was found to be an order of magnitude larger than that of type I and II NAD(P)H dehydrogenases. The reason for the oxidized PQ pool upon inactivation of type II NADH dehydrogenase may be related to the facts that the NAD pool in the cell is much smaller than that of NADP and that the NAD pool is fully reduced in the mutant without type II NADH dehydrogenase, thus causing regulatory inhibition. The results indicate that succinate dehydrogenase is the main respiratory electron transfer pathway into the PQ pool and that type I and II NAD(P)H dehydrogenases regulate the reduction level of NADP and NAD, which, in turn, affects respiratory electron flow through succinate dehydrogenase.
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6

Lacombe, Julie, and Mathieu Ferron. "VKORC1L1, An Enzyme Mediating the Effect of Vitamin K in Liver and Extrahepatic Tissues." Nutrients 10, no. 8 (July 26, 2018): 970. http://dx.doi.org/10.3390/nu10080970.

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Vitamin K is an essential nutrient involved in the regulation of blood clotting and tissue mineralization. Vitamin K oxidoreductase (VKORC1) converts vitamin K epoxide into reduced vitamin K, which acts as the co-factor for the γ-carboxylation of several proteins, including coagulation factors produced by the liver. VKORC1 is also the pharmacological target of warfarin, a widely used anticoagulant. Vertebrates possess a VKORC1 paralog, VKORC1-like 1 (VKORC1L1), but until very recently, the importance of VKORC1L1 for protein γ-carboxylation and hemostasis in vivo was not clear. Here, we first review the current knowledge on the structure, function and expression pattern of VKORC1L1, including recent data establishing that, in the absence of VKORC1, VKORC1L1 can support vitamin K-dependent carboxylation in the liver during the pre- and perinatal periods in vivo. We then provide original data showing that the partial redundancy between VKORC1 and VKORC1L1 also exists in bone around birth. Recent studies indicate that, in vitro and in cell culture models, VKORC1L1 is less sensitive to warfarin than VKORC1. Genetic evidence is presented here, which supports the notion that VKORC1L1 is not the warfarin-resistant vitamin K quinone reductase present in the liver. In summary, although the exact physiological function of VKORC1L1 remains elusive, the latest findings clearly established that this enzyme is a vitamin K oxidoreductase, which can support γ-carboxylation in vivo.
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7

Bradley, C. A., and K. A. Ames. "Effect of Foliar Fungicides on Corn with Simulated Hail Damage." Plant Disease 94, no. 1 (January 2010): 83–86. http://dx.doi.org/10.1094/pdis-94-1-0083.

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Quinone outside inhibitor (QoI) foliar fungicides can be effective at reducing foliar diseases in corn (Zea mays), and they have been shown to provide physiological benefits experimentally in other crops in the absence of disease. A new supplemental label for pyraclostrobin that was approved in January 2009 by the United States Environmental Protection Agency (EPA) states that corn plants applied with pyraclostrobin may have better tolerance to damage caused by hail. To determine the effects of QoI foliar fungicides on hail-damaged corn, field research trials were conducted near Champaign, IL in 2007 and 2008. Hail damage was simulated with a gasoline-powered string-mower at the V12 growth stage, which caused injury to leaves and defoliation. At VT, the foliar fungicides azoxystrobin and pyraclostrobin were applied to corn. Control treatments included a nontreated control and a nondamaged control. The simulated hail damage significantly (P ≤ 0.05) increased gray leaf spot severity (caused by Cercospora zeae-maydis) in 2007 but not in 2008. Simulated hail damage also significantly reduced yield compared with the nondamaged control in both 2007 and 2008. Foliar fungicides significantly reduced disease severity compared with the nontreated control in 2007 but not in 2008; however, foliar fungicides did not significantly improve yield in either the damaged or nondamaged plots compared with the nontreated controls. Results from our research trials indicated that foliar fungicides provided very little benefit to corn injured by simulated hail; thus, growers should consider factors other than hail damage when making fungicide application decisions for corn.
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8

Schnabel, G., and C. H. Crisosto. "Seasonal Applications of a Pyraclostrobin and Boscalid Mixture Do Not Impact Same-year Peach Fruit Quality Attributes." HortTechnology 18, no. 4 (January 2008): 678–84. http://dx.doi.org/10.21273/horttech.18.4.678.

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Quinone outside inhibitor (QoI) fungicides can improve the yield and quality of cereal crops in the absence of disease pressure through the so called “greening effect,” but little is known about the potential beneficial effects on deciduous tree fruit crops. In a multiyear and multicultivar study carried out in South Carolina (2005 and 2006) and California (2006), we examined the potential influence of the QoI fungicide pyraclostrobin on antioxidant activity and commercially important peach (Prunus persica) fruit quality attributes, including fruit size, coloration, firmness, soluble solids concentration, and yield. Experimental orchards were sprayed according to commercial guidelines to manage insect pests and diseases. A pyraclostrobin + boscalid mixture was applied up to five times per season starting 1 week after the physiological stage of “shuck off” until 1 to 2 weeks before harvest. Fruit size was measured weekly between “shuck off” and harvest, whereas the other fruit quality attributes were determined at harvest. Results indicate no consistent impact of the pyraclostrobin + boscalid mixture on same-year fruit size development or other fruit quality attributes in orchards with no or very little disease pressure. To our knowledge, this is the first in-depth evaluation of the potential effects of a QoI fungicide on commercially important tree fruit quality attributes.
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9

Soltani, Sepideh, Shahin Sowlati-Hashjin, Conrard Giresse Tetsassi Feugmo, and Mikko Karttunen. "Structural Investigation of DHICA Eumelanin Using Density Functional Theory and Classical Molecular Dynamics Simulations." Molecules 27, no. 23 (December 1, 2022): 8417. http://dx.doi.org/10.3390/molecules27238417.

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Eumelanin is an important pigment, for example, in skin, hair, eyes, and the inner ear. It is a highly heterogeneous polymer with 5,6-dihydroxyindole-2-carboxylic acid (DHICA) and 5,6-dihydroxyindole (DHI) building blocks, of which DHICA is reported as the more abundant in natural eumelanin. The DHICA-eumelanin protomolecule consists of three building blocks, indole-2-carboxylic acid-5,6-quinone (ICAQ), DHICA and pyrrole-2,3,5-tricarboxylic acid (PTCA). Here, we focus on the self-assembly of DHICA-eumelanin using multi-microsecond molecular dynamics (MD) simulations at various concentrations in aqueous solutions. The molecule was first parameterized using density functional theory (DFT) calculations. Three types of systems were studied: (1) uncharged DHICA-eumelanin, (2) charged DHICA-eumelanin corresponding to physiological pH, and (3) a binary mixture of both of the above protomolecules. In the case of uncharged DHICA-eumelanin, spontaneous aggregation occurred and water molecules were present inside the aggregates. In the systems corresponding to physiological pH, all the carboxyl groups are negatively charged and the DHICA-eumelanin model has a net charge of −4. The effect of K+ ions as counterions was investigated. The results show high probability of binding to the deprotonated oxygens of the carboxylate anions in the PTCA moiety. Furthermore, the K+ counterions increased the solubility of DHICA-eumelanin in its charged form. A possible explanation is that the charged protomolecules favor binding to the K+ ions rather than aggregating and binding to other protomolecules. The binary mixtures show aggregation of uncharged DHICA-eumelanins; unlike the charged systems with no aggregation, a few charged DHICA-eumelanins are present on the surface of the uncharged aggregation, binding to the K+ ions.
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10

Spector, Alan C., and Steven J. St. John. "Role of taste in the microstructure of quinine ingestion by rats." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 274, no. 6 (June 1, 1998): R1687—R1703. http://dx.doi.org/10.1152/ajpregu.1998.274.6.r1687.

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The microstructure of the licking behavior of water-deprived rats presented with either water or quinine during 45-min single-bottle tests was analyzed. The chorda tympani (CT) and glossopharyngeal (GL) nerves, which innervate the taste buds of the tongue, were transected in deeply anesthetized rats to discern their contribution to the behavioral pattern of quinine drinking. Rats were presurgically habituated to the testing protocol and postsurgically tested first with water and then novel 0.2 mM quinine-HCl in a subsequent session. The substantial decrease in intake observed in sham-operated controls ( n = 16) when quinine was the stimulus was entirely a function of a decrease in lick volume and burst size (a run of licks with interlick intervals <1 s). Contrary to the intake-suppressing effects of quinine, pause duration decreased and burst number increased. Combined transection of the CT and GL ( n = 6) strikingly opposed all of these quinine-induced behavioral changes, whereas CT transection ( n = 7) was without effect and GL transection ( n = 8) had an intermediate influence. These results suggest that taste acts more on neural circuits governing burst termination as opposed to burst initiation, which, in turn, appears to be more sensitive to signals related to physiological state. These findings are discussed in terms of other known nerve transection effects on quinine responsiveness, and the implications of the microstructural results are considered with respect to probabilistic as opposed to deterministic control of licking behavior.
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Dissertations / Theses on the topic "Quinone Physiological effect"

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Rozek, Tomas. "Biologically active natural products: ochromycinone analogues and aurein peptides : a thesis presented for the degree of Doctor of Philosophy / by Tomas Rozek." 2000. http://hdl.handle.net/2440/19824.

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Includes copies of articles co-authored by the author during preparation of this thesis.
Includes bibliographical references (leaves 185-191).
v, 192 leaves : ill. ; 30 cm.
Title page, contents and abstract only. The complete thesis in print form is available from the University Library.
Sixteen aurein peptides are present in the host defence secretion from the granular dorsal glands of the Green and Golden Bell Frog (Litoria aurea) and seventeen from those of the related Southern Bell Frog (Litoria raniformis). All peptides have been sequenced using a combination of electrospray mass spectrometry and Lys-C digestion, with each sequence confirmed by automated Edman sequencing. Ten of these peptides are common to both species of frog. Thirteen of the aurein peptides show wide-spectrum antibiotic and anticancer activity.
Thesis (Ph.D.)--Adelaide University, Dept. of Chemistry, 2001
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Books on the topic "Quinone Physiological effect"

1

Edlund, Charlotta. Ecological aspects of new quinolones: Impact on human oropharyngeal and gastrointestinal microflora. Stockholm: Kongl. Karolinska Medico Chirurgiska Institutet, 1989.

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2

Diver, Jonathan Michael. The uptake of quinolone antimicrobial agents into Escherichia coli: Transport mechanisms and physiological effects on cells. Birmingham: University of Birmingham, 1987.

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3

Crumplin, G. C. The 4-Quinolones: Anti Bacterial Agents in Vitro (Springer Series in Applied Biology). Springer, 1990.

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1946-, Crumplin G. C., ed. The 4-quinolones: Anti bacterial agents in vitro. London: Springer-Verlag, 1990.

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Book chapters on the topic "Quinone Physiological effect"

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Smith, J. T. "Effects of Physiological Cation Concentration on 4-Quinolone Absorption and Potency." In The 4-Quinolones: Anti Bacterial Agents in Vitro, 15–21. London: Springer London, 1990. http://dx.doi.org/10.1007/978-1-4471-3449-7_2.

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