Academic literature on the topic 'Quinoxaline dioxide'

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Journal articles on the topic "Quinoxaline dioxide"

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Li, Yuwen, Mei Qiu, Yubin Bai, Shaoqi Qu, and Zhihui Hao. "Improved synthesis of quinocetone and its two desoxymetabolites." Journal of the Serbian Chemical Society 83, no. 3 (2018): 265–70. http://dx.doi.org/10.2298/jsc170614118l.

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Oxidation of o-nitroaniline with sodium hypochlorite afforded benzofurazan oxide in 96 % yield, and treatment of benzofurazan oxide with acetylacetone in the presence of triethylamine gave 2-acetyl-3-methyl-quinoxaline- -1,4-dioxide in 94 % yield. Finally, condensation of 2-acetyl-3-methyl-quinoxaline- 1,4-dioxide with benzaldehyde using 4-(dimethylamino)pyridinium acetate as a catalyst led to quinocetone in 95 % yield. Subsequently, reduction of the synthesized quinocetone with sodium dithionite resulted in two deoxy derivatives, 1-(3-methyl-4-oxido-2-quinoxalinyl)-3-phenyl-2-propen-1-one and
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Nováček, Libor, and Miloslav Nechvátal. "Partial reduction of quinoxaline 1,4-dioxide derivatives with L-ascorbic acid." Collection of Czechoslovak Chemical Communications 53, no. 6 (1988): 1302–6. http://dx.doi.org/10.1135/cccc19881302.

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Partial reduction of quinoxaline 1,4-dioxide derivatives with L-ascorbic acid has been elaborated. Quinoxaline 1,4-dioxide, 2,3-dimethylquinoxaline 1,4-dioxide, 2-methylquinoxaline 1,4-dioxide and 2-(N-(2-hydroxyethyl)carbamoyl)-3-methylquinoxaline 1,4-dioxide afforded monoxides. In the monomethyl derivatives the more distant N-O bond is reduced. In addition to the monoxide, quinoxaline 1,4-dioxide afforded small amount of quinoxaline. Structures of all the compounds have been confirmed by 1H and 13C NMR spectroscopy.
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Silva, Liliana, Pedro Coelho, Dulce Teixeira, et al. "Oxidative Stress Modulation and Radiosensitizing Effect of Quinoxaline-1,4-Dioxides Derivatives." Anti-Cancer Agents in Medicinal Chemistry 20, no. 1 (2020): 111–20. http://dx.doi.org/10.2174/1871520619666191028091547.

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Background: Quinoxaline-1,4-dioxide (QNX) derivatives are synthetic heterocyclic compounds with multiple biological and pharmacological effects. Objective: In this study, we investigated the oxidative status of quinoxaline-1,4-dioxides derivatives in modulating melanoma and glioma cell lines, based on previous results from the research group and their capability to promote cell damage by the production of Reactive Oxygen Species (ROS). Methods: Using in vitro cell cultures, the influence of 2-amino-3-cyanoquinoxaline-1,4-dioxide (2A3CQNX), 3- methyl-2-quinoxalinecarboxamide-1,4-dioxide (3M2QNX
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Dotsenko, Victor V., Karina V. Khalatyan, Alena A. Russkih, and Aminat M. Semenova. "New Quinoxaline-1,4-Dioxides Derived from Beirut Reaction of Benzofuroxane with Active Methylene Nitriles." Chemistry Proceedings 3, no. 1 (2020): 14. http://dx.doi.org/10.3390/ecsoc-24-08391.

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Benzofuroxane reacts under Beirut reaction conditions with active methylene nitriles to give new 2-aminoquinoxaline-1,4-dioxides. The treatment of known 2-amino-3-cyanoquinoxaline-1,4-dioxide with chloroacetyl chloride afforded corresponding chloroacetamide which is useful for the preparation of various heterocycles bearing a quinoxaline-1,4-dioxide core system.
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TAKABATAKE, T., Y. TAKABATAKE, T. MIYAZAWA, and M. HASEGAWA. "ChemInform Abstract: Quinoxaline 1,4-Dioxide. Synthesis and Antibacterial Properties of Quinoxaline 1,4-Dioxide Derivatives." ChemInform 27, no. 48 (2010): no. http://dx.doi.org/10.1002/chin.199648173.

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Peng, Juan, Dezhao Kong, Liqiang Liu, Shanshan Song, Hua Kuang, and Chuanlai Xu. "Determination of quinoxaline antibiotics in fish feed by enzyme-linked immunosorbent assay using a monoclonal antibody." Analytical Methods 7, no. 12 (2015): 5204–9. http://dx.doi.org/10.1039/c5ay00953g.

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Yadav, Pooja, Andrew J. Marshall, Jóhannes Reynisson, William A. Denny, Michael P. Hay, and Robert F. Anderson. "Fragmentation of the quinoxaline N-oxide bond to the ˙OH radical upon one-electron bioreduction." Chem. Commun. 50, no. 89 (2014): 13729–31. http://dx.doi.org/10.1039/c4cc05657d.

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Wang, Xu, Panpan Yang, Juan Li, et al. "Genotoxic risk of quinocetone and its possible mechanism in in vitro studies." Toxicology Research 5, no. 2 (2016): 446–60. http://dx.doi.org/10.1039/c5tx00341e.

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TAKABATAKE, Tohru, Yumiko TAKABATAKE, Tomoyuki MIYAZAWA, and Minoru HASEGAWA. "Synthesis and Antibacterial Properties of Quinoxaline 1, 4-Dioxide Derivatives." YAKUGAKU ZASSHI 116, no. 6 (1996): 491–96. http://dx.doi.org/10.1248/yakushi1947.116.6_491.

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Vicente, Esther, Raquel Villar, Asunción Burguete, et al. "Efficacy of Quinoxaline-2-Carboxylate 1,4-Di-N-Oxide Derivatives in Experimental Tuberculosis." Antimicrobial Agents and Chemotherapy 52, no. 9 (2008): 3321–26. http://dx.doi.org/10.1128/aac.00379-08.

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ABSTRACT This study extends earlier reports regarding the in vitro efficacies of the 1,4-di-N-oxide quinoxaline derivatives against Mycobacterium tuberculosis and has led to the discovery of a derivative with in vivo efficacy in the mouse model of tuberculosis. Quinoxaline-2-carboxylate 1,4-di-N-oxide derivatives were tested in vitro against a broad panel of single-drug-resistant M. tuberculosis strains. The susceptibilities of these strains to some compounds were comparable to those of strain H37Rv, as indicated by the ratios of MICs for resistant and nonresistant strains, supporting the prem
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Dissertations / Theses on the topic "Quinoxaline dioxide"

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Dahbi, Samir. "Chimie innovante en série dioxyde de quinoxaline : vers de nouveaux antituberculeux, inhibiteurs de la biosynthèse des mycobactines." Thesis, Mulhouse, 2012. http://www.theses.fr/2012MULH4078.

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Afin d'internaliser le fer, un micronutriment essentiel pour sa survie, Mycobacterium tuberculosis, la mycobactérie responsable de la tuberculose, biosynthétise des composés ayant une très grande affinité pour Fe3+ appelés les mycobactines. Ces sidérophores sont biosynthétisés par voie non­ ribosomale, la synthèse débutant par l'activation d'une molécule d'acide salicylique par l'enzyme d'adénylation mbtA sous la forme d'un dérivé ester d'adénosylmonophosphate (salicyl-AMP). Notre laboratoire a déjà préparé des analogues stables de salicyl-AMP, inhibiteurs potentiels de la biosynthèse des myco
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Jeena, Vineet. "Photocatalyzed tandem oxidation reactions and their application in the synthesis of quinoxalines." Thesis, 2009. http://hdl.handle.net/10413/945.

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Book chapters on the topic "Quinoxaline dioxide"

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Baars, A. J., E. J. van der Molen, T. J. Spierenburg, G. J. de Graaf, M. J. A. Nabuurs, and L. P. Jager. "Comparative Toxicity of Three Quinoxaline-di-N-dioxide Feed Additives in Young Pigs." In Archives of Toxicology. Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73113-6_77.

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Gobec, S., and U. Urleb. "Deoxygenation of Quinoxaline 1-Oxides and Quinoxaline 1,4-Dioxides." In Six-Membered Hetarenes with Two Identical Heteroatoms. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-016-01092.

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Gobec, S., and U. Urleb. "Quinoxaline 1,4-Dioxides from Benzofuroxan and Dienamines." In Six-Membered Hetarenes with Two Identical Heteroatoms. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-016-01065.

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Gobec, S., and U. Urleb. "Quinoxaline 1,4-Dioxides from Benzofuroxan Derivatives and Enamines or Ynamines." In Six-Membered Hetarenes with Two Identical Heteroatoms. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-016-01063.

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Gobec, S., and U. Urleb. "Quinoxaline 1,4-Dioxides from Benzofuroxan and Enolate Anions Prepared In Situ." In Six-Membered Hetarenes with Two Identical Heteroatoms. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-016-01064.

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Conference papers on the topic "Quinoxaline dioxide"

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Buravchenko, G., I. Treshchalin, S. Alexander, and A. Shchekotikhin. "PO-413 Estimation of antitumor activity of amino derivatives of quinoxaline-2-carbonitrile 1,4-dioxide." In Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June – 3 July 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/esmoopen-2018-eacr25.439.

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Ghattass, Khaled I., Sally El Sitt, Kazem Zibara, Makhlouf MJ Haddadin, Marwan El-Sabban, and Hala Ghali-Muhtasib. "Abstract A99: DCQ is a hypoxia-activated quinoxaline 1,4-dioxide that reduces breast cancer metastasis." In Abstracts: AACR Special Conference on Tumor Invasion and Metastasis - January 20-23, 2013; San Diego, CA. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.tim2013-a99.

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