Academic literature on the topic 'Quinoxaline ring'

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Journal articles on the topic "Quinoxaline ring"

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El-Telbani, Emad M., Ibrahim Radini, and Sameh R. Elgogary. "Syntheses of tricyclic fused quinoxaline ring systems: Pyrazoloquinoxalines (a-review)." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 35, no. 02 (2025): 279. https://doi.org/10.59467/ijhc.2025.35.279.

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Quinoxaline derivatives have gained significant interest due to their diverse pharmacological activity and have been included in numerous marketed drugs used to treat of various diseases. Examples include glecaprevir (Mavyret), voxilaprevir (Vosevi), Balversa (L01EX16) (erdafitinib), carbadox, XK469R (NSC698215), and becampanel (AMP397). Among the five-membered fused tricyclic quinoxalines ring systems, the pyrazoloquinolines belong to the azaheterocyclic group as derivatives of quinoxalines and pyrazoles and have characterized by many biological and pharmaceutical properties. There are three
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Elgogary, Sameh R., Emad M. El-Telbani, and Ibrahim Radini. "Syntheses and Biological Activities of Tricyclic-fused Quinoxaline Ring Systems (A Review). Part I: Thienoquinoxalines." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 34, no. 02 (2024): 173. http://dx.doi.org/10.59467/ijhc.2024.34.173.

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Quinoxaline derivatives are an interesting class of heterocyclic compounds in drug discovery. It is rare in natural state, but their synthesis is easy to perform coupling between benzene and pyrazine rings. In addition, quinoxaline nucleus has received notable attention as an important pharmacophore that has broad-spectrum applications, especially in the fields of pharmaceutics and medicine. This review spotlights the biological activities and the different methods of preparation of three isomers of thienoquinoxalines, namely thieno[2,3-b]quinoxaline, thieno[3,4-b]quinoxaline, and thieno[2,3-g
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Ridhima, Chauhan, S. Chundawat N., and Pal Singh Girdhar. "Quinoxaline Derivatives: Synthesis and Biological Significance." Pharmaceutical and Chemical Journal 10, no. 3 (2023): 137–47. https://doi.org/10.5281/zenodo.13995628.

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Quinoxaline is a well-known and important nitrogen-containing heterocyclic compound with a complex ring consisting of a benzene ring and a pyrazine ring. Different modified quinoxalines and their derivatives with various functional groups are an important part of biological science, and important research projects are introduced in this course. Many methods have been developed to combine them. The demonstration that many quinoxaline derivatives have many biological activities encourages research in this field. There are many useful drugs such as antibiotics, antibiotics, antibiotics, antibioti
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Ou, Zhongping, Wenbo E, Jianguo Shao, et al. "Electrochemical and spectroelectrochemical properties of building blocks for molecular arrays: reactions of quinoxalino[2,3-b]porphyrins containing metal(II) ions." Journal of Porphyrins and Phthalocyanines 09, no. 02 (2005): 142–51. http://dx.doi.org/10.1142/s1088424605000216.

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Quinoxalino[2,3-b]porphyrins are laterally-extended porphyrins with aromatic ring systems fused to the β,β'-positions of a pyrrolic ring of the macrocycle. They are building blocks for coplanar laterally-extended oligoporphyrins with applications in molecular electronics. The electrochemistry and spectroelectrochemistry of four such quinoxalinoporphyrins containing metal(II) ions and one free-base quinoxalinoporphyrin dissolved in nonaqueous media have been investigated and the data are compared to that seen for the same derivatives of the parent macrocycle lacking the fused quinoxaline ring.
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Zayed, Mohamed F. "Chemistry, Synthesis, and Structure Activity Relationship of Anticancer Quinoxalines." Chemistry 5, no. 4 (2023): 2566–87. http://dx.doi.org/10.3390/chemistry5040166.

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Quinoxaline is a fused heterocycle system of a benzene ring and pyrazine ring. It has earned considerable attention due to its importance in the field of medicinal chemistry. The system is of extensive importance due to its comprehensive array of biological activities. Quinoxaline derivatives have been used as anticancer, anticonvulsant, anti-inflammatory, antidiabetic, antioxidant, antibacterial, anti-TB, antimalarial, antiviral, anti-HIV, and many other uses. Variously substituted quinoxalines are significant therapeutic agents in the pharmaceutical industry. This review spotlights on the ch
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Mohamed, Hanan A., Mohammad Hayal Alotaibi, Benson M. Kariuki, and Gamal A. El-Hiti. "Convenient Synthesis of New Heterocycles Containing the Quinoxaline Ring System." Letters in Organic Chemistry 17, no. 2 (2020): 121–26. http://dx.doi.org/10.2174/1570178616666190311161505.

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: The aim of the current article was to describe simple procedures for the synthesis of new heterocycles incorporating the quinoxaline moiety using benzene-1,2-diamine and quinoxaline-2,3- dithiol as precursors. Simple synthetic methods are described for the synthesis of new heterocycles using commercially available chemicals. Also, the new compounds were determined using analytical and spectroscopic methods including single X-ray crystal structures. A series of new heterocycles containing the quinoxaline nucleus have been synthesized in good yields using simple and convenient procedures. A pr
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Wang, Cui-Ping, Saiyong Ma, Jiang-Long Yu, Jing-Bo Yan, and Zhi-Qiang Zhang. "2-(4-Fluorophenyl)quinoxaline." Acta Crystallographica Section E Structure Reports Online 68, no. 6 (2012): o1779. http://dx.doi.org/10.1107/s1600536812017771.

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In the title compound, C14H9FN2, the dihedral angle between the benzene ring and the quinoxaline ring system is 22.2 (3)°. Any aromatic π–π stacking in the crystal must be very weak, with a minimum centroid–centroid separation of 3.995 (2) Å.
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Montero, Vincent, Marc Montana, Omar Khoumeri, Florian Correard, Marie-Anne Estève, and Patrice Vanelle. "Synthesis, In Vitro Antiproliferative Activity, and In Silico Evaluation of Novel Oxiranyl-Quinoxaline Derivatives." Pharmaceuticals 15, no. 7 (2022): 781. http://dx.doi.org/10.3390/ph15070781.

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The quinoxaline core is a promising scaffold in medicinal chemistry. Multiple quinoxaline derivatives, such as the topoisomerase IIβ inhibitor XK-469 and the tissue transglutaminase 2 inhibitor GK-13, have been evaluated for their antiproliferative activity. Previous work reported that quinoxaline derivatives bearing an oxirane ring present antiproliferative properties against neuroblastoma cell lines SK-N-SH and IMR-32. Likewise, quinoxalines with an arylethynyl group displayed promising antineoplastic properties against glioblastoma and lung cancer cell lines, U87-MG and A549 respectively. H
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Ouyang, Xi-Lin, Miao Ouyang, and Shi-Wen Huang. "6-Chloro-2-phenyl-3-(2-phenylethynyl)quinoxaline." Acta Crystallographica Section E Structure Reports Online 68, no. 6 (2012): o1741. http://dx.doi.org/10.1107/s1600536812020776.

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In the title compound, C22H13ClN2, the quinoxaline ring system is close to planar [maximum deviation = 0.061 (2) Å]. The phenyl ring at the 2-position and the phenyl ring of the phenylethynyl substituent make dihedral angles of 49.32 (7) and 11.99 (7) °, respectively, with the quinoxaline mean plane. The two phenyl rings are inclined to one another by 61.27 (9)°. In the crystal, molecules are linked by C—H...π and π–π interactions [centroid–centroid distances = 3.6210 (12) and 3.8091 (12) Å].
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Elgogary, Sameh R., and Emad M. El-Telbani. "Synthesis of tricyclic fused quinoxaline ring systems: Isoxazolo-, oxazolo-, isothiazolo- and thiazoloquinoxalines (a review)." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 35, no. 02 (2025): 263. https://doi.org/10.59467/ijhc.2025.35.263.

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Quinoxaline derivatives have gained great interest because they exhibit a variety of pharmacological activities, including antibacterial, antitubercular, antiviral, anti-HIV, anti-inflammatory, antifungal, anticancer, antiproliferative, antitumor, kinase inhibition, antimicrobial, antioxidant, and analgesic effects. Recognizing the importance of these bioactive quinoxaline derivatives, researchers have dedicated their efforts to develop different synthetic routes for their production. This review aims to compile the most recent findings on the synthesis of quinoxaline derivatives incorporating
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Dissertations / Theses on the topic "Quinoxaline ring"

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Sadiq, Samina. "Studies of some fused-ring heterocycles and 2,6-Diarylpyridine derivatives." Thesis, Brunel University, 1999. http://bura.brunel.ac.uk/handle/2438/7281.

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This work reported is divided into two parts: the first part deals with quinoxaline derivatives and includes the preparation and characterisation of novel linear tricyclic quinones 1,4-diazanthracen-9,10-diones, (54) and (55). The reaction of diazanaphthoquinones and 1-acetyl-1,3-butadiene are used to produce these quinones through the Diels-Alder reaction. In addition hexaazapentacyclic 5,6,7,12,13, 14-hexaazapentacene was prepared by the reaction ofbis(2-chloroquinoxalin-3-yl)sulfide with thioxamide and the reaction of the sulfide with amines was investigated. Two different approaches to 6,1
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Kolay, Merve. "Dibenzophenazine And Quinoxaline Derivatives As Novel Visible Photosensitizers For Diaryliodonium Salts." Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613419/index.pdf.

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This study is focused on the use of visible light in photoinitiated cationic polymerization. Photoinitiated polymerization of oxiranes, vinyl ethers, and other vinyl monomers was achieved. In doing so, (2-(2,3 dihydrobenzo [b][1,4]dioxin-6-yl)-3-(2,3-dihydrobenzo[b]-[1,4]dioxin-7-yl)-5-(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)-8-(2,3-dihydrothieno[3,4-b][1,4]dioxin-7yl) quinoxaline) (DBQEd) and poly(2,3,5,8-tetra(thiophen-2-yl)quinoxaline) (TTQ), two dibenzo[a,c]phenazine derivatives<br>10,13-bis(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)dibenzo[a,c] phenazine (PHED) and 10,13-bis(4-hexylthiop
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Wu, Yu-Che, and 吳宇哲. "Columnar Bimetallomesogens: Copper Complexes Derived from Quinoxaline Ring." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/45762898552800414132.

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碩士<br>國立中央大學<br>化學研究所<br>94<br>In this thesis, we report the synthesis, characterization and mesomorphic properties of new mesogenic derivatives based on quinoxaline structure. In series one , A new type of binuclear transition metal complexes derived from 2,3-bis(3.4-dialkoxylphenyl)quinoxaline-6-carboxylic-[(2 -hydrox y-4-alkoxylphenylimino)methyl]-phenyl esters was prepared and characterized. The mesomorphic properties of these copper comple -xes of were studied by differential scanning calorimetry (DSC) and polarized optical microscope (POM). These complexes have two metal centers as core
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Chen, Szu-young, and 陳思仰. "Synthesis of the Quinoxaline-Ring Fused U-Shaped Polycyclic Molecules Having Pendant Aryl Group." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/54874393327652930241.

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碩士<br>國立中正大學<br>化學所<br>95<br>Quinoxaline-rings fused U-shaped polycyclic molecules, which containing pendant aryl groups, have been synthesized by the Williamson ether synthesis reaction that introduced the aryl groups into the spacer of the U-shaped molecules. The framework of U-shaped molecules were establish by a combination of the ruthenium-catalyzed oxidation of vicinal dichloroalkenes and the zinc-catalyzed condensation of resulting bis-?diketones with 1,2-diaminobenzene or 2,3-diaminonaphthalene starting from the second Diels-Alder adduct of 5,5-dimethoxy-1,2,3,4-tetrachlorocyclopentadi
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Li, Yong-Jie, and 李永傑. "Bis-Quinoxaline Ring-fused U-Shaped Molecules Bearing N-Arylimide: Synthesis and Molecular Assembly." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/08516386741922253216.

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碩士<br>國立中正大學<br>化學所<br>97<br>The synthetic route to the bis-quinoxaline ring-fused U-shaped molecules bearing N-Arylimide begin from Diels-Alder adduct 19. Through three steps transformation lead to U-shaped imide molecules QNH and BQNH. Then reacted with 2-(bromomethyl)nathalene, 9-(bromomethyl)anthracene, 1-(bromomethyl)pyrene via SN2 reaction to construct a series of U-shaped molecules. These U-shaped molecules show the special self-assembled π-stacking in the X-ray crystallography. The similar self-assembly property could be proved in solution state by the 1H NMR titration method, furtherm
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Books on the topic "Quinoxaline ring"

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Simpson, J. C. Pyridazine and Pyrazine Rings : (Cinnolines, Phthalazines, and Quinoxalines). Wiley & Sons, Incorporated, John, 2009.

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Book chapters on the topic "Quinoxaline ring"

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Roy, Priyabrata. "TANDEM GENERATION OF FURO [3, 4-b] PYRAZINE AND FURO [3, 4-b] QUINOXALINE INTERMEDIATES USING FISCHER CARBENE COMPLEXES AND TRAPPING FOR SYNTHESIS OF NITROGEN HETEROCYCLES." In Futuristic Trends in Chemical Material Sciences & Nano Technology Volume 3 Book 25. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3becs25p2ch8.

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An unique method for tandem generation of furo[3,4-b]pyrazine and furo[3,4-b]quinoxaline intermediates using Fischer carbene complexes and then trapping with suitable dienophiles to generate nitrogen heterocycles has been described. The intermediate is trapped with a dienophile to generate quinoxaline or phenazine ring system respectively.
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Grimmett, M. R. "Ring Contractions of Quinoxaline -Oxides." In Five-Membered Hetarenes with Two Nitrogen or Phosphorus Atoms. Georg Thieme Verlag KG, 2002. http://dx.doi.org/10.1055/sos-sd-012-00723.

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McKeown, N. B. "Preparation of 1,8,12,19,23,30,34,41-Octaaza-2,3-anthracenocyanines from Benzo[]quinoxaline-2,3-dicarbonitrile." In Six-Membered Hetarenes with Two Unlike or More than Two Heteroatoms and Fully Unsaturated Larger-Ring Heterocycles. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-017-01933.

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Lindsley, C. W., and M. E. Layton. "Reactions of [1,2,5]Oxadiazolo[3,4-]quinoxaline 1-Oxides with Nitrile Oxides." In Six-Membered Hetarenes with Two Unlike or More than Two Heteroatoms and Fully Unsaturated Larger-Ring Heterocycles. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-017-00698.

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McKeown, N. B. "Preparation of 2,3,11,12(13,14),20,21(22,23),29,30(31,32)-Tetrabenzo-1,6,10,15,19,24,29,33-octaaza-2,3-naphthalocyanines from ­Benzo[]quinoxaline-2,3-dicarbonitrile." In Six-Membered Hetarenes with Two Unlike or More than Two Heteroatoms and Fully Unsaturated Larger-Ring Heterocycles. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-017-01932.

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Harris, P. A. "10.24.4 Product Subclass 4: Pyrazino[1,2-a]indoles and Related Benzo-Fused Ring Systems." In Science of Synthesis: Knowledge Updates 2021/3. Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/sos-sd-110-02056.

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AbstractThe synthesis of pyrazino[1,2-a]indoles and related indolo[1,2-a]quinoxalines and pyrido[2′,1′:3,4]pyrazino[1,2-a]indol-5-ium salts are reviewed in this chapter. The most common routes to pyrazino[1,2-a]indoles involve cyclization of indole derivatives containing a formyl, keto, ester, or nitrile function at the 2-position. Indolo[1,2-a]quinoxalines are most readily accessed via cyclization of 1-(aryl)-1H-indoles, where the aryl group is substituted at the 2-position by either amino, iodo, or nitro functionality.
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"Product Class 15: Quinoxalines." In Category 2, Hetarenes and Related Ring Systems, edited by Yamamoto and Shinkai. Georg Thieme Verlag, 2004. http://dx.doi.org/10.1055/sos-sd-016-01007.

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"Quinoxalines Unsubstituted in the Hetero Ring." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186558.ch25.

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"Formation of Quinoxalines from Compounds Containing a Furan Ring." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186558.ch35.

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Lindsley, C. W., and M. E. Layton. "Oxidation of 1-Amino-2-quinoxalones." In Six-Membered Hetarenes with Two Unlike or More than Two Heteroatoms and Fully Unsaturated Larger-Ring Heterocycles. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-017-00702.

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