Academic literature on the topic 'Quinpirole'

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Journal articles on the topic "Quinpirole"

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de Haas, Ria, Annelies Nijdam, Tjalke A. Westra, Martien JH Kas, and Herman GM Westenberg. "Behavioral pattern analysis and dopamine release in quinpirole-induced repetitive behavior in rats." Journal of Psychopharmacology 25, no. 12 (2010): 1712–19. http://dx.doi.org/10.1177/0269881110389093.

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Obsessive–compulsive disorder (OCD) is a chronic and disabling psychiatric disease with a lifetime prevalence of 2–3%. People with OCD suffer from intrusive, unwanted and recurrent thoughts (obsessions) and/or repetitive ritualistic behaviors (compulsions). The aim of this study is to quantify the dimensions of ritualistic ‘compulsive-like’ behavior in quinpirole-induced behavior in rats by using T-pattern behavioral analysis. In addition, we investigated whether the behavioral effects elicited by quinpirole sensitization remained after 2 weeks of cessation of treatment. Finally, to study the
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Mannhold, R. "Quinpirole hydrochloride." Drugs of the Future 12, no. 6 (1987): 558. http://dx.doi.org/10.1358/dof.1987.012.06.51471.

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THORESON, WALLACE B., SALVATORE L. STELLA, ERIC J. BRYSON, JOHN CLEMENTS, and PAUL WITKOVSKY. "D2-like dopamine receptors promote interactions between calcium and chloride channels that diminish rod synaptic transfer in the salamander retina." Visual Neuroscience 19, no. 3 (2002): 235–47. http://dx.doi.org/10.1017/s0952523802192017.

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Activation of D2-like dopamine receptors in rods with quinpirole stimulates L-type calcium currents (ICa). This result appears inconsistent with studies showing that D2-like dopamine receptor activation diminishes rod signals in second-order retinal neurons. Since small reductions in [Cl−]i can inhibit photoreceptor ICa, we tested the hypothesis that enhancement of ICa with the D2/D4 receptor agonist, quinpirole, increases calcium-activated chloride currents (ICl(Ca)) causing an efflux of Cl− from rods that would provide a negative feedback inhibition of ICa. In agreement with studies from Xen
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Alam, Sayed Ibrar, Min Gi Jo, Tae Ju Park, et al. "Quinpirole-Mediated Regulation of Dopamine D2 Receptors Inhibits Glial Cell-Induced Neuroinflammation in Cortex and Striatum after Brain Injury." Biomedicines 9, no. 1 (2021): 47. http://dx.doi.org/10.3390/biomedicines9010047.

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Brain injury is a significant risk factor for chronic gliosis and neurodegenerative diseases. Currently, no treatment is available for neuroinflammation caused by the action of glial cells following brain injury. In this study, we investigated the quinpirole-mediated activation of dopamine D2 receptors (D2R) in a mouse model of traumatic brain injury (TBI). We also investigated the neuroprotective effects of quinpirole (a D2R agonist) against glial cell-induced neuroinflammation secondary to TBI in adult mice. After the brain injury, we injected quinpirole into the TBI mice at a dose of 1 mg/k
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FAN, SHIH-FANG, and STEPHEN YAZULLA. "Inhibitory interaction of cannabinoid CB1 receptor and dopamine D2 receptor agonists on voltage-gated currents of goldfish cones." Visual Neuroscience 21, no. 1 (2004): 69–77. http://dx.doi.org/10.1017/s0952523804041070.

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Dopamine is a light-adaptive signal that desensitizes the retina, while cannabinoids reportedly increase photosensitivity. The presynaptic membrane of goldfish retinal cones has dopamine D2 receptors and cannabinoid CB1 receptors. This work focused on whether dopamine D2 receptor agonist quinpirole and cannabinoid CB1 receptor agonist WIN 55212-2 (WIN) interacted to modulate voltage-dependent membrane currents of cones. A conventional patch-clamp method was used to record depolarization evoked whole-cell outward currents (Iout) and an inward calcium current (ICa) from the inner segment of cone
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Kohnomi, Shuntaro, Noriaki Koshikawa, and Masayuki Kobayashi. "D2-like dopamine receptors differentially regulate unitary IPSCs depending on presynaptic GABAergic neuron subtypes in rat nucleus accumbens shell." Journal of Neurophysiology 107, no. 2 (2012): 692–703. http://dx.doi.org/10.1152/jn.00281.2011.

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In the nucleus accumbens (NAc), a medium spiny (MS) neuron receives GABAergic inputs from two major sources: fast-spiking (FS) neurons and other, adjacent MS neurons. These two types of inhibitory synapses are considered to play different roles in output activities, i.e., FS→MS connections suppress output from the NAc whereas MS→MS connections contribute to lateral inhibition. In the present study, we focused on the electrophysiological properties of unitary inhibitory postsynaptic currents (uIPSCs) obtained from MS→MS connections and FS→MS connections and examined the effects of quinpirole, a
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Akopian, A., and P. Witkovsky. "D2 dopamine receptor-mediated inhibition of a hyperpolarization-activated current in rod photoreceptors." Journal of Neurophysiology 76, no. 3 (1996): 1828–35. http://dx.doi.org/10.1152/jn.1996.76.3.1828.

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1. Using the whole cell patch clamp method, we investigated the effect of dopamine on a hyperpolarization-activated current (Ih) in the inner segments of rod photoreceptors of the Xenopus retina. 2. Ih was elicited by hyperpolarizing voltage steps to -120 mV from a holding potential of -40 mV. Dopamine reversibly reduced Ih in a dose-dependent manner. Dopamine-mediated inhibition of Ih was blocked by the D2 dopamine antagonist sulpiride. 3. The D2 dopamine agonist quinpirole (0.1-20 microM) inhibited Ih whereas the D1 agonist SKF-38393 (100 microM) had no effect on Ih. Quinpirole-induced inhib
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Fedotova, Julia. "Effects of Stimulation and Blockade of Receptor on Depression-Like Behavior in Ovariectomized Female Rats." ISRN Pharmacology 2012 (March 1, 2012): 1–8. http://dx.doi.org/10.5402/2012/305645.

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The aim of the present study was to explore the hedonic effects of D2 receptor agonist, quinpirole and D2 receptor antagonist, and sulpiride alone or in combination with a low dose of 17β-E2-estradiol (17β-E2) in the adult ovariectomized female rats (OVX). OVX rats of Wistar strain were used in all experiments. Two weeks after surgery rats were chronically treated with vehicle, a low dose of 17β-E2 (5.0 μg/rat), quinpirole (0.1 mg/kg), sulpiride (10.0 mg/kg), quinpirole plus 17β-E2, or sulpiride plus 17β-E2 for 14 days before the forced swimming test. We found that sulpiride significantly decr
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Wang, Xiaoyan, Van Anthony Villar, Andrew Tiu, Kiran K. Upadhyay, and Santiago Cuevas. "Dopamine D2 receptor upregulates leptin and IL-6 in adipocytes." Journal of Lipid Research 59, no. 4 (2018): 607–14. http://dx.doi.org/10.1194/jlr.m081000.

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Leptin is a pro-inflammatory cytokine secreted by the adipose tissue. Dopamine D2 receptors (D2Rs) have anti-inflammatory effects in the brain and kidney tissues. Mouse and human adipocytes express D2R; D2R protein was 10-fold greater in adipocytes from human visceral tissue than subcutaneous tissue. However, the function of D2R in adipocytes is not well understood. 3T3-L1 cells were treated with D2-like receptor agonist quinpirole, and immunoblot and quantitative PCR were performed. Quinpirole increased the protein and mRNA expression of leptin and IL-6, but not adiponectin and visfatin (24 h
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Eilam, David, and Henry Szechtman. "Psychostimulant-Induced Behavior as an Animal Model of Obsessive-Compulsive Disorder: An Ethological Approach to the Form of Compulsive Rituals." CNS Spectrums 10, no. 3 (2005): 191–202. http://dx.doi.org/10.1017/s109285290001004x.

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AbstractRats treated chronically with the D2/D3, dopamine receptor agonist quinpirole show a pattern of behavior that meets a set of ethologically derived criteria of compulsive behavior in obsessive-compulsive disorder (OCD). Moreover, in both quinpirole-treated rats and OCD patients, the structure of compulsive rituals appear similar in being composed of relatively few motor acts that are organized in a flexible yet recurrent manner. In addition, the development of compulsive behavior in quinpirole-treated rats is attenuated by the OCD pharmacotherapeutic drug clomipramine. These similaritie
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Dissertations / Theses on the topic "Quinpirole"

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Thacker, Stephanie K. "Chronic Olanzapine Treatment Eliminates Cognitive Deficits Produced by Neonatal Quinpirole Treatment." Digital Commons @ East Tennessee State University, 2005. https://dc.etsu.edu/etd/1011.

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This study evaluated the effects of chronic olanzapine treatment on cognitive performance and neurochemical function in a rodent model of schizophrenia. Animals were neonatally treated with quinpirole, a dopamine D2 receptor agonist, or saline. Quinpirole treatment produces an increase of dopamine D2 receptor sensitivity that extends into adulthood, known as D2 receptor priming, similar to a phenomenon that occurs in schizophrenia. These same rats were treated in adulthood for 28 days with olanzapine, an atypical antipsychotic, or saline. Dopamine D2- primed rats demonstrated significant defic
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Thompson, K. N., Ivy A. Click, R. A. Best, S. K. Thacker, and Russell W. Brown. "Acute Eticlopride Treatment Alleviates Cognitive Deficits Produced by Neonatal Quinpirole Treatment." Digital Commons @ East Tennessee State University, 2004. https://dc.etsu.edu/etsu-works/6408.

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This study was designed to investigate the effects of acute eticlopride (0.02 mg/kg, D2 antagonist) treatment, given immediately before training, in rats neonatally treated with quinpirole, which has been shown to produce long-term D2 receptor supersensitization. Rats were given quinpirole (1mg/kg) or saline treatment from P1-21. Beginning on P22, rats were administered eticlopride or saline (i.p.) fifteen mins before each of seven days of training. Rats were tested on the Morris water task (MWT). For the first three consecutive days, rats were tested on the place version of the MWT with a sta
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Brown, Russell W., Amanda M. Maple, Marla K. Perna, A. Brianna Sheppard, Zackary A. Cope, and Richard M. Kostrzewa. "Schizophrenia and Substance Abuse Comorbidity: Nicotine Addiction and the Neonatal Quinpirole Model." Digital Commons @ East Tennessee State University, 2012. https://doi.org/10.1159/000338830.

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Perna, Marla K., Zackary A. Cope, Amanda M. Maple, Ian D. Longacre, Jennifer A. Correll, and Russell W. Brown. "Nicotine Sensitization in Adult Male and Female Rats Quinpirole-Primed as Neonates." Digital Commons @ East Tennessee State University, 2008. https://dc.etsu.edu/etsu-works/6359.

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RATIONALE: Increases in dopamine D2-like receptor function are common in several psychological disorders that demonstrate a four to five fold increase in nicotine abuse compared to the general population.OBJECTIVE: The objective of this study was to analyze the interaction of sex differences and sensitization to nicotine in rats D2 receptor primed as neonates.MATERIALS AND METHODS: A total of 32 male and 32 female Sprague-Dawley rats derived from eight litters were ontogenetically treated with quinpirole (1 mg/kg) or saline from postnatal days (P) 1-21 and raised to adulthood. At P60, all anim
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Perreault, Melissa Loretta Szechtman Henry. "Coactivation of kappa opioid receptors modulates sensitized responses to the dopamine agonist quinpirole." *McMaster only, 2006.

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Maple, Amanda M., Katherine J. Smith, Marla K. Perna, and Russell W. Brown. "Neonatal Quinpirole Treatment Produces Prepulse Inhibition Deficits in Adult Male and Female Rats." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etsu-works/947.

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We have shown that repeated neonatal quinpirole (QUIN; a dopamine D2-like receptor agonist) treatment in rats produces long-lasting supersensitization of dopamine D2 receptors that persists into adulthood but without producing a change in receptor number. The current study was designed to analyze the effects of neonatal QUIN on auditory sensorimotor gating as measured through prepulse inhibition (PPI). Male and female Sprague–Dawley rats were neonatally treated with QUIN (1mg/kg) or saline from postnatal days (P)1–21. At P60, the number of yawns was recorded for a 1h period in response to an a
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Gill, Wesley, Liza J. Hernandez, Wyatt S. Whicker, Kate C. Burgess, Charlotte L. Kaestner, and Russell W. Brown. "EPIGENETIC TRANSMISSION OF NICOTINIC EFFECTS WITHIN THE NEONATAL QUINPIROLE RODENT MODEL OF SCHIZOPHRENIA." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/68.

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Schizophrenia is a neurological disorder found in approximately 1% of the population. It is estimated that as many as 88% of individuals diagnosed which schizophrenia smoke tobacco, a rate which is greatly increased compared to the general population. While increased use of nicotine-containing products such as cigarettes may be detrimental to the long-term health of individuals with schizophrenia, it has been hypothesized that nicotine use is a form of self-medication for these individuals who suffer from serious neurological and psychological symptoms such as hallucinations, delusions, anhedo
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Brown, Russell W., J. T. Gass, Ivy A. Click, et al. "Ontogenetic Quinpirole Treatment Produces Spatial Memory Deficits and Reaching Accuracy Enhancement in Rats." Digital Commons @ East Tennessee State University, 2001. https://dc.etsu.edu/etsu-works/6410.

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Past studies have shown that ontogenetic treatment of quinpirole (QNP) produces a number of behavioral effects that can be alleviated by administration of antipsychotics such as haloperidol, providing a useful behavioral screen for disorders such as schizophrenia. In this study, 16 female Sprague-dawley rats were used, with 8 rats injected with QNP(1 mg/kg) and 8 rats injected with saline once daily from postnatal days (PD) 1-11. All rats were behaviorally tested as adults on several tasks: The reference and working memory versions of the Morris water task (MWT), the radial arm maze (RAM), the
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Gill, Wesley D., J. D. Wherry, Katherine C. Burgess, and Russell W. Brown. "Prepulse Inhibition Deficits in the Neonatal Quinpirole Model of Schizophrenia: Epigenetic Evidence and Sex Differences." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/969.

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Neonatal quinpirole (QUIN; dopamine D2/D3 agonist) administered from postnatal days (P)1-21 results in an increase of dopamine D2 receptor sensitivity, similar to schizophrenia and is now an established rodent model of schizophrenia. The day after birth, male and female Sprague-Dawley rats were given a daily 1 mg/kg injection of either QUIN or saline from P1-21. One subset of these animals were behaviorally tested on PPI, referred to as first generation (F0). A different subset of animals were allowed to reach adult age (P60) and female and male QUIN-treated pairs from separate litters were br
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Brown, Russell W., Justin T. Gass, and Richard M. Kostrzewa. "Ontogenetic Quinpirole Treatments Produce Spatial Memory Deficits and Enhance Skilled Reaching in Adult Rats." Digital Commons @ East Tennessee State University, 2002. https://dc.etsu.edu/etsu-works/6348.

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There is a paucity of data on neurochemical abnormalities and associated effects on cognition and motor performance in rats ontogenetically treated with quinpirole, a rodent model of dopaminergic hyperfunction. The objective of the current study was to analyze the cognitive and motor effects produced by ontogenetic administration of quinpirole, a dopamine D2/D3 receptor agonist. Past research from this laboratory has shown that ontogenetic quinpirole treatment sensitizes D2 receptors and produces a variety of characteristic stereotypic behaviors in adult rats. In the current study, rats receiv
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Books on the topic "Quinpirole"

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Pierre, Joel St. The effects of quinpirole in eliciting 50 kHz calls from the rat nucleus accumbens. Brock University, Dept. of Psychology, 2008.

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Book chapters on the topic "Quinpirole"

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Brown, Russell W., and Daniel J. Peterson. "Applications of the Neonatal Quinpirole Model to Psychosis and Convergence upon the Dopamine D2 Receptor." In Neurotoxin Modeling of Brain Disorders—Life-long Outcomes in Behavioral Teratology. Springer International Publishing, 2015. http://dx.doi.org/10.1007/7854_2015_394.

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Enna, S. J., and David B. Bylund. "Quinpirole." In xPharm: The Comprehensive Pharmacology Reference. Elsevier, 2007. http://dx.doi.org/10.1016/b978-008055232-3.63318-5.

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