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Dissertations / Theses on the topic 'Quinpirole'

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Published: 4 June 2021

Last updated: 3 February 2022

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1

Thacker, Stephanie K. "Chronic Olanzapine Treatment Eliminates Cognitive Deficits Produced by Neonatal Quinpirole Treatment." Digital Commons @ East Tennessee State University, 2005. https://dc.etsu.edu/etd/1011.

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This study evaluated the effects of chronic olanzapine treatment on cognitive performance and neurochemical function in a rodent model of schizophrenia. Animals were neonatally treated with quinpirole, a dopamine D2 receptor agonist, or saline. Quinpirole treatment produces an increase of dopamine D2 receptor sensitivity that extends into adulthood, known as D2 receptor priming, similar to a phenomenon that occurs in schizophrenia. These same rats were treated in adulthood for 28 days with olanzapine, an atypical antipsychotic, or saline. Dopamine D2- primed rats demonstrated significant defic

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Thompson, K. N., Ivy A. Click, R. A. Best, S. K. Thacker, and Russell W. Brown. "Acute Eticlopride Treatment Alleviates Cognitive Deficits Produced by Neonatal Quinpirole Treatment." Digital Commons @ East Tennessee State University, 2004. https://dc.etsu.edu/etsu-works/6408.

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This study was designed to investigate the effects of acute eticlopride (0.02 mg/kg, D2 antagonist) treatment, given immediately before training, in rats neonatally treated with quinpirole, which has been shown to produce long-term D2 receptor supersensitization. Rats were given quinpirole (1mg/kg) or saline treatment from P1-21. Beginning on P22, rats were administered eticlopride or saline (i.p.) fifteen mins before each of seven days of training. Rats were tested on the Morris water task (MWT). For the first three consecutive days, rats were tested on the place version of the MWT with a sta

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3

Brown, Russell W., Amanda M. Maple, Marla K. Perna, A. Brianna Sheppard, Zackary A. Cope, and Richard M. Kostrzewa. "Schizophrenia and Substance Abuse Comorbidity: Nicotine Addiction and the Neonatal Quinpirole Model." Digital Commons @ East Tennessee State University, 2012. https://doi.org/10.1159/000338830.

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4

Perna, Marla K., Zackary A. Cope, Amanda M. Maple, Ian D. Longacre, Jennifer A. Correll, and Russell W. Brown. "Nicotine Sensitization in Adult Male and Female Rats Quinpirole-Primed as Neonates." Digital Commons @ East Tennessee State University, 2008. https://dc.etsu.edu/etsu-works/6359.

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RATIONALE: Increases in dopamine D2-like receptor function are common in several psychological disorders that demonstrate a four to five fold increase in nicotine abuse compared to the general population.OBJECTIVE: The objective of this study was to analyze the interaction of sex differences and sensitization to nicotine in rats D2 receptor primed as neonates.MATERIALS AND METHODS: A total of 32 male and 32 female Sprague-Dawley rats derived from eight litters were ontogenetically treated with quinpirole (1 mg/kg) or saline from postnatal days (P) 1-21 and raised to adulthood. At P60, all anim

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5

Perreault, Melissa Loretta Szechtman Henry. "Coactivation of kappa opioid receptors modulates sensitized responses to the dopamine agonist quinpirole." *McMaster only, 2006.

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6

Maple, Amanda M., Katherine J. Smith, Marla K. Perna, and Russell W. Brown. "Neonatal Quinpirole Treatment Produces Prepulse Inhibition Deficits in Adult Male and Female Rats." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etsu-works/947.

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We have shown that repeated neonatal quinpirole (QUIN; a dopamine D2-like receptor agonist) treatment in rats produces long-lasting supersensitization of dopamine D2 receptors that persists into adulthood but without producing a change in receptor number. The current study was designed to analyze the effects of neonatal QUIN on auditory sensorimotor gating as measured through prepulse inhibition (PPI). Male and female Sprague–Dawley rats were neonatally treated with QUIN (1mg/kg) or saline from postnatal days (P)1–21. At P60, the number of yawns was recorded for a 1h period in response to an a

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Gill, Wesley, Liza J. Hernandez, Wyatt S. Whicker, Kate C. Burgess, Charlotte L. Kaestner, and Russell W. Brown. "EPIGENETIC TRANSMISSION OF NICOTINIC EFFECTS WITHIN THE NEONATAL QUINPIROLE RODENT MODEL OF SCHIZOPHRENIA." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/68.

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Schizophrenia is a neurological disorder found in approximately 1% of the population. It is estimated that as many as 88% of individuals diagnosed which schizophrenia smoke tobacco, a rate which is greatly increased compared to the general population. While increased use of nicotine-containing products such as cigarettes may be detrimental to the long-term health of individuals with schizophrenia, it has been hypothesized that nicotine use is a form of self-medication for these individuals who suffer from serious neurological and psychological symptoms such as hallucinations, delusions, anhedo

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8

Brown, Russell W., J. T. Gass, Ivy A. Click, et al. "Ontogenetic Quinpirole Treatment Produces Spatial Memory Deficits and Reaching Accuracy Enhancement in Rats." Digital Commons @ East Tennessee State University, 2001. https://dc.etsu.edu/etsu-works/6410.

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Past studies have shown that ontogenetic treatment of quinpirole (QNP) produces a number of behavioral effects that can be alleviated by administration of antipsychotics such as haloperidol, providing a useful behavioral screen for disorders such as schizophrenia. In this study, 16 female Sprague-dawley rats were used, with 8 rats injected with QNP(1 mg/kg) and 8 rats injected with saline once daily from postnatal days (PD) 1-11. All rats were behaviorally tested as adults on several tasks: The reference and working memory versions of the Morris water task (MWT), the radial arm maze (RAM), the

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9

Gill, Wesley D., J. D. Wherry, Katherine C. Burgess, and Russell W. Brown. "Prepulse Inhibition Deficits in the Neonatal Quinpirole Model of Schizophrenia: Epigenetic Evidence and Sex Differences." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/969.

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Neonatal quinpirole (QUIN; dopamine D2/D3 agonist) administered from postnatal days (P)1-21 results in an increase of dopamine D2 receptor sensitivity, similar to schizophrenia and is now an established rodent model of schizophrenia. The day after birth, male and female Sprague-Dawley rats were given a daily 1 mg/kg injection of either QUIN or saline from P1-21. One subset of these animals were behaviorally tested on PPI, referred to as first generation (F0). A different subset of animals were allowed to reach adult age (P60) and female and male QUIN-treated pairs from separate litters were br

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10

Brown, Russell W., Justin T. Gass, and Richard M. Kostrzewa. "Ontogenetic Quinpirole Treatments Produce Spatial Memory Deficits and Enhance Skilled Reaching in Adult Rats." Digital Commons @ East Tennessee State University, 2002. https://dc.etsu.edu/etsu-works/6348.

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There is a paucity of data on neurochemical abnormalities and associated effects on cognition and motor performance in rats ontogenetically treated with quinpirole, a rodent model of dopaminergic hyperfunction. The objective of the current study was to analyze the cognitive and motor effects produced by ontogenetic administration of quinpirole, a dopamine D2/D3 receptor agonist. Past research from this laboratory has shown that ontogenetic quinpirole treatment sensitizes D2 receptors and produces a variety of characteristic stereotypic behaviors in adult rats. In the current study, rats receiv

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11

Roberts, Addie. "Nicotine Sensitization and Brain-Derived Neurotrophic Factor Content in Adolescent Rats Neonatally Treated with Quinpirole." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/honors/21.

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Neonatal treatment of quinpirole in rats increases dopamine D2-like receptor sensitivity over the animal’s lifetime, a phenomenon referred to as D2 priming. Male and female Sprague-Dawley rats were given quinpirole (1mg/kg, i.p.) or saline on postnatal days (P)1-21. After habituation to a locomotor arena on P29-31, beginning P33, animals were administered nicotine (0.3 mg/kg, 0.5 mg/kg, or 0.7 mg/kg, i.p.) or saline and placed into a locomotor arena for behavioral testing every second day for a total of 9 treatments. The results showed that adolescents neonatally treated with quinpirole produc

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12

Peterson, Daniel. "The Effects of Nicotine in the Neonatal Quinpirole Rodent Model of Schizophrenia: Neural Plasticity Mechanisms." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etd/3083.

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The current study was designed to analyze the roles of both α7 and α4β2 nicotinic receptors (nAChRs) in behavioral sensitization and its effects on Brain Derived Neurotrophic Factors (BDNF) and the mammalian target of rapamycin (mTOR) in the neonatal quinpirole model of schizophrenia. Animals were treated neonatally with either quinpirole (1 mg/kg) or saline starting on P1 and treatment persisted through P21. Starting on P33, animals were sensitized to nicotine (0.5 mg/kg free base) every other day up to P49. Following sensitization, brains were harvested at 1 h and 24 h post-drug treatment an

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Brown, Russell W., and Daniel J. Peterson. "Applications of the Neonatal Quinpirole Model to Psychosis and Convergence upon the Dopamine D2 Receptor." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etsu-works/946.

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This mini review focuses on the importance of the dopamine D2-like receptor family and its importance in psychosis. Past findings from this laboratory along with collaborators have been that neonatal quinpirole (a dopamine D2-like receptor agonist) results in increases in dopamine D2 receptor sensitivity that persists throughout the animal’s lifetime. Findings from this model have been shown to have particular application and validity to schizophrenia, but may have broader implications toward other psychoses, which is reviewed in the present manuscript. In the present review, we also highlight

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Gill, Wesley. "Behavioral and Neurobiological Evidence of Epigenetic Transmission in the Neonatal Quinpirole Rodent Model of Schizophrenia." Digital Commons @ East Tennessee State University, 2005. https://dc.etsu.edu/etd/3719.

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Quinpirole is a dopamine D2 receptor agonist that if administered to rats from postnatal day (P)1-21 results in increased dopamine D2 receptor sensitivity throughout the animal’s lifetime. This increase in receptor sensitivity is consistent with schizophrenia. This model has additional consistencies with human schizophrenia, including sensorimotor gating deficits, enhanced behavioral and neurobiological responses to nicotine, and protein alterations consistent with the disorder. In this study, a second generation of the neonatal quinpirole (NQ) rodent model was created to investigate if long t

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Gill, Wesley. "Behavioral and Neurobiological Evidence of Epigenetic Transmission in the Neonatal Quinpirole Rodent Model of Schizophrenia." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/etd/3719.

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Quinpirole is a dopamine D2 receptor agonist that if administered to rats from postnatal day (P)1-21 results in increased dopamine D2 receptor sensitivity throughout the animal’s lifetime. This increase in receptor sensitivity is consistent with schizophrenia. This model has additional consistencies with human schizophrenia, including sensorimotor gating deficits, enhanced behavioral and neurobiological responses to nicotine, and protein alterations consistent with the disorder. In this study, a second generation of the neonatal quinpirole (NQ) rodent model was created to investigate if long t

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Hernandez, Liza. "Alcohol Consumption in a Preclinical Model of Schizophrenia." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/etd/3693.

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Schizophrenia is a debilitating psychiatric disorder that affects approximately 1% of the global population. Schizophrenia is highly comorbid with other psychiatric disorders such as Alcohol Use Disorder (AUD) with a prevalence rate of 27% - 65%, which is significantly higher than AUD exhibited by the general population (6%). Research indicates that a higher rate of AUD in individuals suffering from schizophrenia may be related to the common neuronal pathways that underlie the expression of both disorders. The present study will determine whether the neonatal quinpirole (NQ) rodent model of sc

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Denton, Adam Ray. "The Effects of Antipsychotic Treatment upon Nicotine Associative Reward in a Neonatal Quinpirole Model of Schizophrenia." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/honors/339.

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Research has revealed that schizophrenics are significantly more likely to smoke cigarettes than the general population, and consume nicotine products at a much more prevalent rate. Further exacerbating this issue, it has been previously demonstrated in clinical populations that the type of antipsychotic treatment administered (typical versus atypical) may result in either an increase or a decrease of already heightened smoking behavior within the schizophrenic population. With these clinical issues in mind, the present study sought to examine the effects of antipsychotic treatment upon the as

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Kirby, Seth, Elizabeth D. Cummins, Daniel J. Peterson, Leigh Kassem, and Russell W. Brown. "A Test of the Rewarding Versus Aversive Effects of Nicotine in Rats Neonatally Treated with Quinpirole." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etsu-works/972.

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Aims: Neonatal quinpirole (a dopamine D2-like agonist) treatment to rats has been shown to increase dopamine D2 receptor sensitivity throughout the animal’s lifetime, and increased dopamine D2 sensitivity is a hallmark of schizophrenia. Schizophrenics are 3 to 4 times more likely to smoke than the normal population, but there is no delineating mechanism. Aim 1: Behaviorally test a rewarding versus averisve dose of nicotine in adolescent rats neonatally treated with quinpirole tested in a place preference paradigm; Aim 2: Analyze phosphorylated cylic AMP response element bidning protein (CREB)

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Denton, Adam, Seth L. Kirby, Katherine C. Burgess, J. D. Wherry, John M. Dose, and Russell W. Brown. "Behavioral and Plasticity Mechanisms of the Associative Effects of Nicotine in the Neonatal Quinpirole Model of Schizophrenia." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/970.

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Schizophrenics are significantly more likely to smoke cigarettes than the general population. In Experiment 1, we analyzed the effects of a rewarding versus an aversive dose of nicotine using the neonatal quinpirole (QUIN; dopamine D2/D3 agonist) model of schizophrenia. In Experiment 2, we examined the effects of antipsychotic treatment upon the associative reward of nicotine within this same model. Neonatal QUIN treatment to rats results in increased dopamine D2 receptor sensitivity throughout the rat’s lifetime, consistent with schizophrenia. Rats were neonatally treated with QUIN (1 mg/kg d

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Brown, Russell W., Marla K. Perna, Daniel M. Noel, Jamie D. Whittemore, Julia Lehmann, and Meredith L. Smith. "Amphetamine Locomotor Sensitization and Conditioned Place Preference in Adolescent Male and Female Rats Neonatally Treated with Quinpirole." Digital Commons @ East Tennessee State University, 2010. https://dc.etsu.edu/etsu-works/6341.

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Neonatal quinpirole treatment has been shown to produce an increase in dopamine D2-like receptor sensitivity that persists throughout the subject's lifetime. The objective was to analyze the effects of neonatal quinpirole treatment on effects of amphetamine in adolescent rats using locomotor sensitization and conditioned place preference procedures. Sprague-Dawley rats were treated with quinpirole (1 mg/kg) or saline from postnatal days (P)1 to P11 and raised to adolescence. For locomotor sensitization, subjects were given amphetamine (1 mg/kg) or saline every second day from P35 to P47 and we

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Perna, Marla K., Yoko O. Henderson, Christopher L. Bruner, and Russell W. Brown. "An Analysis of Nicotine Conditioned Place Conditioning in Early Postweanling and Adolescent Rats Neonatally Treated with Quinpirole." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etsu-works/6342.

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This study investigated nicotine place conditioning in early postweanling and adolescent male and female rats neonatally treated with quinpirole, a dopamine D(2)/D(3) agonist. Previous research has shown that neonatal quinpirole treatment results in an increase of dopamine D(2)-like receptor sensitivity that persists throughout the animal's lifetime, relevant to psychosis. Rats were neonatally treated with quinpirole or saline from postnatal day (P)1-21, and animals were conditioned with nicotine or saline daily from P23-30 as early postweanlings or P32-39 as adolescents in a two- or three-cha

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Kostrzewa, Richard M., Przemysław Nowak, Ryszard Brus, and Russell W. Brown. "Perinatal Treatments with the Dopamine D2-Receptor Agonist Quinpirole Produces Permanent D2-Receptor Supersensitization: A Model of Schizophrenia." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/945.

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Repeated daily treatments of perinatal rats with the dopamine D2-receptor (D2-R) agonist quinpirole for a week or more produces the phenomenon of ‘priming’—gradual but long-term sensitization of D2-R. In fact a daily dose of quinpirole as low as 50 µg/kg/day is adequate for sensitizing D2-R. Primed rats as neonates and in adolescence, when acutely treated with quinpirole display enhanced eating/gnawing/nursing on dams, also horizontal locomotor activity. Between 3 and 5 weeks of age, acute quinpirole treatment of primed rats produces profound vertical jumping with paw treading—a behavior that

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Brown, Russell W., Kimberly N. Thompson, Ivy A. Click, Razaria A. C. Best, Stephanie K. Thacker, and Marla K. Perna. "The Effects of Eticlopride on Morris Water Task Performance in Male and Female Rats Neonatally Treated with Quinpirole." Digital Commons @ East Tennessee State University, 2005. https://dc.etsu.edu/etsu-works/6354.

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RATIONALE: Previous studies have shown that neonatal quinpirole treatment which results in long-term dopamine D2 receptor supersensitization (D2 receptor priming) produces cognitive deficits in preweanling and adult rats behaviorally tested on the Morris water task (MWT).OBJECTIVE: This study was designed to analyze whether pretraining administration of the D2 antagonist eticlopride alleviates cognitive deficits produced by neonatal quinpirole treatment.METHODS: Both male and female Sprague-Dawley rats were treated with quinpirole HCl (1 mg/kg) or saline from postnatal days 1 to 21. From P22 t

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Brown, Russell W., Marla K. Perna, Tori L. Schaefer, and Michael T. Williams. "The Effects of Adulthood Nicotine Treatment on D2-Mediated Behavior and Neurotrophins of Rats Neonatally Treated with Quinpirole." Digital Commons @ East Tennessee State University, 2006. https://doi.org/10.1002/syn.20237.

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This study was designed to analyze the effects of nicotine on yawning behavior and neurotrophin content in the hippocampus and frontal cortex of D2-receptor primed female adult Sprague-Dawley rats. Animals were neonatally treated with quinpirole, a dopamine (DA) D2/D3 agonist, from postnatal day 1-21 (P1-21) and raised to P60 and administered nicotine tartarate (0.3 mg/kg free base) or saline twice daily for 14 days. One day after nicotine treatment had ceased, the number of yawns was recorded for 1 h in response to an acute injection of quinpirole (i.p., 100 microg/kg). Yawning is a D2-recept

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Peterson, Daniel J., Wesley Drew Gill, John M. Dose, et al. "The Effects of Nicotine in the Neonatal Quinpirole Rodent Model of Psychosis: Neural Plasticity Mechanisms and Nicotinic Receptor Changes." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/942.

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Neonatal quinpirole (NQ) treatment to rats increases dopamine D2 receptor sensitivity persistent throughout the animal’s lifetime. In Experiment 1, we analyzed the role of α7 and α4β2 nicotinic receptors (nAChRs) in nicotine behavioral sensitization and on the brain-derived neurotrophic factor (BDNF) response to nicotine in NQ- and neonatally saline (NS)-treated rats. In Experiment 2, we analyzed changes in α7 and α4β2 nAChR density in the nucleus accumbens (NAcc) and dorsal striatum in NQ and NS animals sensitized to nicotine. Male and female Sprague-Dawley rats were neonatally treated with q

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Brown, Russell W., Marla K. Perna, Amanda M. Maple, Tracy D. Wilson, and Barney E. Miller. "Adulthood Olanzapine Treatment Fails to Alleviate Decreases of Chat and BDNF RNA Expression in Rats Quinpirole-Primed as Neonates." Digital Commons @ East Tennessee State University, 2008. https://dc.etsu.edu/etsu-works/6358.

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Neonatal quinpirole (dopamine D(2)/D(3) agonist) treatment to rats has been shown to increase dopamine D(2) receptor sensitivity throughout the animal's lifetime. Male and female Sprague-Dawley rats were neonatalally treated with quinpirole (1 mg/kg) from postnatal days (P) 1-21 and raised to adulthood. Beginning on P62, rats were administered the atypical antipsychotic olanzapine (2.5 mg/kg) twice daily for 28 days. Starting 1 day after the end of olanzapine treatment, animals were behaviorally tested on the place and match-to-place version of the Morris water maze (MWM) over seven consecutiv

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Brown, Russell W., Kenyatta D. Thompson, Kimberly N. Thompson, et al. "Adulthood Nicotine Treatment Alleviates Behavioural Impairments in Rats Neonatally Treated with Quinpirole: Possible Roles of Acetylcholine Function and Neurotrophic Factor Expression." Digital Commons @ East Tennessee State University, 2004. https://dc.etsu.edu/etsu-works/6351.

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Increases in dopamine D(2) receptor sensitivity are known to be common in drug abuse and neurological disorders. Past data from this laboratory have shown that long-term increases in D(2) sensitivity can be produced by quinpirole treatment (a D(2)/D(3) agonist) during early development. The present investigation was designed to test the hypothesis that nicotine administration in adulthood would reduce both cognitive and skilled reaching impairments produced by increases in D(2) sensitivity. Female Sprague-Dawley rats were treated with quinpirole (1 mg/kg) or saline from postnatal day 1 (PD 1)

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Cope, Zackary A., Kimberly N. Huggins, A. Brianna Sheppard, Daniel M. Noel, David S. Roane, and Russell W. Brown. "Neonatal Quinpirole Treatment Enhances Locomotor Activation and Dopamine Release in the Nucleus Accumbens Core in Response to Amphetamine Treatment in Adulthood." Digital Commons @ East Tennessee State University, 2010. https://doi.org/10.1002/syn.20729.

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Neonatal quinpirole treatment to rats produces long-term increases in D(2) receptor sensitivity that persists throughout the animal's lifetime, a phenomenon referred to as D(2) priming. Male and female Sprague-dawley rats were administered quinpirole (1 mg kg(-1)) or saline from postnatal days (P)1-11. At P60, all animals were given an injection of quinpirole (100 microg kg(-1)), and results showed that rats neonatally treated with quinpirole demonstrated enhanced yawning in response to quinprole, verifying D(2) receptor priming because yawning is a D(2) receptor mediated event. Beginning 1-3

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Peterson, Daniel J., Courtney M. Bardo, Elizabeth D. Cummins, and Russell W. Brown. "The Role of the Alpha7 and Alpha4 Beta2 Nicotinic Receptors in Nicotine Sensitization and Neural Plasticity in Rats Neonatally Treated with Quinpirole." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etsu-works/959.

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Aims: We have established that neonatal treatment with quinpirole, a dopamine D2/D3 agonist, results in increases of dopamine D2 receptor sensitivity throughout the animal’s lifetime and has a number of consistencies with schizophrenia. Aim 1: Analyze the roles of α7 and α4β2 nicotinic receptors in nicotine sensitization in adolescent male and female rats neonatally treated with quinpirole. Aim 2: The roles of the α7 and α4β2 nicotinic receptors were analyzed in their effects on Brain-Derived Neurotrophic Factor (BDNF) and mammalian target of rapamycin (mTOR) in rats neonatally treated with qu

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Sheppard, Brianna, Julia Lehmann, Zackary A. Cope, and Russell W. Brown. "Sex Differences in Nicotine Sensitization and Conditioned Hyperactivity in Adolescent Rats Neonatally Treated with Quinpirole: Role of D2 and D3 Receptor Subtypes." Digital Commons @ East Tennessee State University, 2009. https://doi.org/10.1037/a0017536.

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Neonatal quinpirole treatment in rats produces increased sensitivity of dopamine D2-like receptors throughout the animal's lifetime, referred to D2 priming. There is little information on the effects of nicotine in adolescent rats, especially in a model that has clinical relevance to psychosis where increased D2 receptor sensitivity is common. Male and female rats were treated with quinpirole (1 mg/kg) or saline from postnatal (P) day P21, given nicotine (0.5 mg/kg) or saline from P33 through P49, and placed into a locomotor arena for behavioral testing. Nicotine or saline treatment was preced

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Brown, Russell W., Timothy J. Flanigan, Kimberly N. Thompson, Stephanie K. Thacker, Tori L. Schaefer, and Michael T. Williams. "Neonatal Quinpirole Treatment Impairs Morris Water Task Performance in Early Postweanling Rats: Relationship to Increases in Corticosterone and Decreases in Neurotrophic Factors." Digital Commons @ East Tennessee State University, 2004. https://dc.etsu.edu/etsu-works/6353.

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Background Past studies from this laboratory have shown that quinpirole administration from postnatal day (P) 1–21 produces persistent supersensitization of the dopamine D2 receptor that persists throughout the animal's lifetime. Methods In Experiment 1, both male and female rats were treated with quinpirole or saline from P1–21 and tested on the place and match-to-place versions of the Morris water task (MWT) from P22–28. In Experiment 2, both male and female rats were administered either acute or chronic injections of quinpirole (1 mg/kg) or saline beginning on P1 until analysis for cort

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Thacker, Stephanie K., Marla K. Perna, Jeffery J. Ward, et al. "The Effects of Adulthood Olanzapine Treatment on Cognitive Performance and Neurotrophic Factor Content in Male and Female Rats Neonatally Treated with Quinpirole." Digital Commons @ East Tennessee State University, 2006. https://dc.etsu.edu/etsu-works/6356.

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Male and female Sprague-Dawley rats were administered quinpirole (1 mg/kg, i.p.) or saline once daily from postnatal day (P)1 to P21. This drug treatment has been shown to produce long-term priming of the D2 receptor. Beginning on P62, rats were administered the atypical antipsychotic olanzapine (2.5 mg/kg) or saline twice daily (i.p.) for 28 days. One day after olanzapine treatment ceased, rats were tested on the place and match-to-place versions of the Morris water maze (MWM) for seven consecutive days. Dopamine D2 receptor priming was verified through a yawning behavioural test, a D2 recept

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Maple, Amanda M., Marla K. Perna, Joshua P. Parlaman, Gregg D. Stanwood, and Russell W. Brown. "Ontogenetic Quinpirole Treatment Produces Long-Lasting Decreases in the Expression of RGS9, but Increases RGS17 in the Striatum, Nucleus Accumbens and Frontal Cortex." Digital Commons @ East Tennessee State University, 2007. https://dc.etsu.edu/etsu-works/6357.

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Ontogenetic treatment of rats with the dopamine D(2)-like receptor agonist quinpirole produces a significant increase in dopamine D(2) receptor sensitivity that persists throughout the animal's lifetime, a phenomenon known as D(2) priming. The present study was designed to investigate the effects of priming of the D(2) receptor on the expression of three different members of the regulator of G-protein signaling (RGS) family: Rgs4, Rgs9 and Rgs17. Male offspring were ontogenetically treated with quinpirole or saline from postnatal days (P)1-21 and raised to adulthood. On approximately P65, anim

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Brown, Russell W., Marjorie A. Schlitt, Alex S. Owens, et al. "Effects of Environmental Enrichment on Nicotine Sensitization in Rats Neonatally Treated with Quinpirole: Analyses of Glial Cell Line-Derived Neurotrophic Factor and Implications towards Schizophrenia." Digital Commons @ East Tennessee State University, 2018. https://doi.org/10.1159/000486391.

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The current study analyzed the effects of environmental enrichment versus isolation housing on the behavioral sensitization to nicotine in the neonatal quinpirole (NQ; dopamine D2-like agonist) model of dopamine D2 receptor supersensitivity, a rodent model of schizophrenia. NQ treatment in rats increases dopamine D2 receptor sensitivity throughout the animal's lifetime, consistent with schizophrenia. Animals were administered NQ (1 mg/kg) or saline (NS) from postnatal day (P)1 to P21, weaned, and immediately placed into enriched housing or isolated in wire cages throughout the experiment. Rats

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Brown, Russell W., Seth L. Kirby, Adam R. Denton, et al. "An Analysis of the Rewarding and Aversive Associative Properties of Nicotine in the Neonatal Quinpirole Model: Effects on Glial Cell Line-Derived Neurotrophic Factor (GDNF)." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/940.

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This study analyzed the associative properties of nicotine in a conditioned place preference (CPP) paradigm in adolescent rats neonatally treated with quinpirole (NQ) or saline (NS). NQ produces dopamine D2 receptor supersensitivity that persists throughout the animal's lifetime, and therefore has relevance towards schizophrenia. In two experiments, rats were ip administered quinpirole (1mg/kg) or saline from postnatal day (P)1–21. After an initial preference test at P42–43, animals were conditioned for eight consecutive days with saline or nicotine (0.6mg/kg free base) in Experiment 1 or sali

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Lalonde, Christian. "Implication des récepteurs D¦2 dans la tâche de labyrinthe radial win-stay chez le rat." Master's thesis, Université Laval, 1998. http://hdl.handle.net/20.500.11794/42249.

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Une injection intrastriatale de l'agoniste D2 quinpirole facilite l'apprentissage de la tâche de labyrinthe radial win-stay (Packard et White, 1991). Trois expériences sont effectuées pour approfondir l'étude de l'implication des récepteurs dopaminergiques D2 dans ce type l'apprentissage et aussi pour vérifier l'impact de cet effet sur l'expression du proto-oncogène c-fos. Dans la première étude nous parvenons à répliquer l'effet facilitateur du quinpirole mais il comporte des faiblesses et nous reprenons la procédure dans une deuxième étude. Dans cette deuxième étude un groupe supplémentaire

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Peterson, Daniel J., Jim Wherry, Elizabeth D. Cummins, Don Hoover та Russell W. Brown. "The Role of the Α7 and Α4β2 Nicotinic Receptors in Nicotine Sensitization and Neural Plasticity of Adolescent Rats Neonatally Treated with Quinpirole: Effects on Mtor and Nicotinic Receptor Density". Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/2769.

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Aims: (1) Analyze the roles of α7 and α4β2 nicotinic receptors (nAChRs) in nicotine sensitization in adolescent male and female rats neonatally treated with quinpirole as well as their effects on brain-derived neurotrophic factor (BDNF) and mammalian target of rapamycin (mTOR) 1 h and 24 h post drug treatment. (2) Analyze the effects of behavioral sensitization to nicotine on α7 and α4β2 nAChR density in the nucleus accumbens and dorsal striatum. Methods: Animals were neonatally treated with quinpirole (1 mg/kg) or saline from postnatal days (P)1-21. Beginning on P33, animals were ip injected

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Reinel, Claudia. "Multidisziplinäre Untersuchung dopaminerger Mechanismen der repetitiven Störungen anhand von zwei Rattenmodellen dopaminerger Dysregulation." Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2015. http://dx.doi.org/10.18452/17390.

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Repetitive Störungen manifestieren sich als Leitsymptom in der Zwangsstörung und dem Tourette-Syndrom. Die Symptome werden als enthemmte Stereotypien eines desinhibierten Basalganglien-thalamo-kortikalen (BGTC) Regelkreises verstanden. Überdies wird als neurochemisches Korrelat ein dysregulatives Dopamin (DA)-System innerhalb dieser Kerngebiete nahegelegt, welches über ein überaktives Dopamintransporter (DAT)-System erklärt werden könnte. In der Induktion repetitiver Erkrankungen ist die Interaktion des BGTC Regelkreises und des DA-Systems dennoch unklar. In der vorliegenden Arbeit wurden da

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Kaur, Navneet 1979. "Anatomical mapping of dopamine receptor supersensitivity in the rat extended striatum." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112522.

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The extended striatum is a large, dopamine-innervated forebrain structure comprising the caudate-putamen, nucleus accumbens and olfactory tubercle (OT). The OT remains largely unexplored, despite its potentially important role in behaviour and dopamine (DA)-mediated reward. One method of studying function is examining "supersensitive" behavioural responses to DA agonists in animals after striatal DA loss. We examined whether D1 or D2 receptor supersensitivity occurs in the OT and neighbouring islands of Calleja (ICj), after unilateral 6-hydroxydopamine lesions of the medial forebrain bundle an

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Cope, Zackary Adam. "Amphetamine Sensitization and in vivo Microdialysis of the Nucleus Accumbens Core of Adult Male and Female Rats D2-Primed as Neonates." Digital Commons @ East Tennessee State University, 2008. https://dc.etsu.edu/etd/1953.

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Neonatal administration of quinpirole produces significant increases in D2 receptor sensitivity that persists into adulthood. This phenomenon, known as D2 receptor priming, is consistent with pathology in schizophrenia. Rats were administered quinpirole or saline postnatally and raised to adulthood. In adulthood, rats were administered d-amphetamine sulfate or saline every other day and were placed in a locomotor arena where activity was measured over 7 trials. Results showed that D2-primed rats receiving amphetamine were higher in locomotor activity across all days of testing compared to othe

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Caetano, Kátia Alessandra de Souza. "Envolvimento de mecanismos dopaminérgicos na expressão do medo condicionado contextual em ratos." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/59/59134/tde-14052012-182651/.

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É reconhecido que as experiências que geram reações de medo são praticamente indeléveis do encéfalo dos organismos e que condicionamentos aversivos suscitam inúmeras respostas defensivas, como o congelamento, sendo esta resposta um indicador de medo em roedores. Vários trabalhos têm apontado para a relação entre alterações na transmissão dopaminérgica e os estados aversivos. Entretanto, observam-se resultados conflitantes com a utilização de drogas dopaminérgicas em diferentes modelos animais de ansiedade. Assim, investigações devem ainda ser realizadas objetivando avaliar a funcionalidade da

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Oliveira, Amanda Ribeiro de. "Mecanismos dopaminérgicos na aquisição e expressão do medo condicionado: envolvimento de receptores D1 e D2." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/59/59134/tde-30032006-144132/.

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O aumento do reflexo de sobressalto na presença de um estímulo que tenha sido previamente pareado a choques nas patas é tomado como índice de medo e nomeado sobressalto potencializado pelo medo (SPM). O congelamento, interrupção de todos os movimentos observáveis, exceto aqueles associados com a respiração, também tem sido utilizado como índice de medo em ratos. Um crescente número de evidências sugere o envolvimento de mecanismos dopaminérgicos em diferentes aspectos da memória afetiva, como sua formação, evocação e expressão. No entanto, resultados sobre como e por meio de quais receptores o

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Wieske, Franziska [Verfasser]. "Neurobiologische Substrate repetitiven Verhaltens im Quinpirol Rattenmodell der Zwangsstörung / Franziska Wieske." Berlin : Freie Universität Berlin, 2015. http://d-nb.info/1073868753/34.

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Ogawa, Yoko Emily. "The Effects of Nicotine Conditioned Place Preference in D2 Primed Adolescent Rats: Age-Related and Gender Effects." Digital Commons @ East Tennessee State University, 2007. https://dc.etsu.edu/etd/2129.

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This study investigated nicotine conditioned place preference (CPP) in two different ages of adolescence using a rodent model of schizophrenia. Both 2- and 3-chambered CPP apparatuses were used to test whether the CPP was due to an aversion to the white chamber. Animals were neontally treated with the dopamine D2/D3 agonist, quinpirole, or saline and raised to either early postweanling age (P 22) or adolescence (P 29). Rats were conditioned to prefer the white chamber using nicotine. Results showed that nicotine induced CPP and appeared to alleviate an increased stress response in D2 primed an

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Banzhaf, Johann [Verfasser]. "Auswirkungen der tiefen Hirnstimulation des Nucleus Entopeduncularis auf zwanghaftes Verhalten im Quinpirol-Tiermodell für Zwangskrankheit / Johann Banzhaf." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2011. http://d-nb.info/1026264227/34.

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"Chronic Olanzapine Treatment Eliminates Cognitive Deficits Produced by Neonatal Quinpirole Treatment." East Tennessee State University, 2005. http://etd-submit.etsu.edu/etd/theses/available/etd-0403105-181043/.

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Radostová, Dominika. "Vliv klomipraminu a risperidonu na učení a flexibilitu u animálního modelu obsedantně kompulzivní poruchy." Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-353841.

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Chronic sensitization of dopamine D2/D3 receptors by agonist quinpirole (QNP) induces compulsive checking behaviour in rats, which is considered an animal model of obsessive-compulsive disorder (OCD). Previous study revealed deficit in cognitive flexibility in QNP sensitized rats. This thesis focused on determining if this cognitive flexibility deficit is ameliorated by co-administration of clomipramine (CMI), risperidone (RIS) or combination of both (CMI+RIS) to QNP treatment. Aversively motivated active place avoidance task on a Carousel maze with reversal was used. The number of entrances i

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Huang, Jian-Jia, and 黃建嘉. "Effects of dopamine D2 receptor agonist quinpirole on neuronal activity of anterior cingulate cortex and striatum." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/04910071968404067581.

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碩士<br>國立宜蘭大學<br>生物機電工程學系碩士班<br>96<br>Quinpirole is a high-affinity agonist of dopamine D2/D3 receptors. In rats, systemic quinpirole administration across a wide dose range produces an acute behavioral response with first a period of locomotor inhibition and then a long-lasting period of hyperlocomotion. If treated chronically with quinpirole, rats exhibit characteristic behaviors similar to some of humans diagnosed with obsessive-compulsive disorder (OCD). The aim of the present project study was to investigate the changes of neuronal activity in the anterior cingulate cortex (ACC) and striat

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Brožka, Hana. "Narušená Funkce Hipokampu u Modelu Obsedantně-Kompulsivní Poruchy Vyvolané Quinpirolem." Doctoral thesis, 2020. http://www.nusl.cz/ntk/nusl-411035.

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Obsessive-compulsive disorder (OCD) is a serious psychiatric condition manifested by repeated thoughts followed by stereotypic compulsive behavior. Alterations to cortico-thalamo-striato- cortical circuits are most often implicated in the pathophysiology of OCD. However, many studies have also found a changed volume, shape and activity of the hippocampus in OCD patients. This work focused on the activity of hippocampal CA1 cells during stereotypical checking behavior and on cognitive flexibility in a quinpirole (QNP) sensitization model of OCD. The activity of CA1 hippocampal cells during ster

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Tse, Gavin. "Characterizing a Role for Dopamine on Sleep and Cataplexy in Narcoleptic Mice." Thesis, 2008. http://hdl.handle.net/1807/11171.

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Narcolepsy is a disabling sleep disorder that is characterized by persistent sleepiness, and cataplexy – an involuntary loss of waking muscle tone. Cataplexy and narcolepsy are caused by the loss of hypocretin containing neurons in the hypothalamus. However, it is hypothesized that dopamine is also involved in sleep and motor control and plays a role in cataplexy. This study investigated how manipulating dopamine affected sleep and cataplexy in narcoleptic mice devoid of hypocretin. We used d-amphetamine to increase endogenous dopamine levels and quinpirole (D2 agonist) to agonize D2 receptor

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