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Relevant bibliographies by topics / Quinuclidine

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Journal articles
Dissertations / Theses
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Academic literature on the topic 'Quinuclidine'

Author: Grafiati

Published: 4 June 2021

Last updated: 7 February 2022

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Journal articles on the topic "Quinuclidine"

1

Crnčević, Doris, and Renata Odžak. "Synthesis of quaternary ammonium salts based on quinuclidin-3-ol and pyridine-4-aldoxime with alkyl chains." St open 1 (2020): 1–8. http://dx.doi.org/10.48188/so.1.8.

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Aim: In search of a new class of potential antimicrobial agents, novel ammonium salts based on quinuclidine-3-ol and pyridine-4-aldoxime with different lengths of alkyl chains were synthesized and analyzed. In addition to their potential biological application, newly synthesized salts containing terminal bromine could possibly be used for the synthesis of more potent bisquaternary salts. Methods: The commercially available quinuclidine-3-ol and pyridine-4-aldoxime were used for the synthesis of new derivatives with the appropriate alkyl chains. The purity of the synthesized salts was tested by

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Borowiak, Teresa, Grzegorz Dutkiewicz, and Jacek Thiel. "Structure of Diastereomeric 10-Bromo-10,11-dihydroquinines." Zeitschrift für Naturforschung B 57, no. 5 (2002): 586–92. http://dx.doi.org/10.1515/znb-2002-0517.

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The absolute configurations of new chiral centers in the side chains of diastereomeric 10,11-dihydroquinines, C20H25BrN2O2, have been determined. Both diastereomers with either 10R or 10S configuration adopt the conformations in which quinuclidine nitrogen atom points away from the quinoline ring (open conformations). The bulky C3-side chain in the 10R diastereomer hinders intermolecular hydrogen bond formation to the quinuclidinic, more basic nitrogen atom. Instead, the hydrogen bond to the quinolinic N atom is formed which is an unusual case for Cinchona alkaloid crystal packing. The same bu

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Hamama, Wafaa S., Osama M. Abd El-Magid, and Hanafi H. Zoorob. "Synthetic Entry to Tricyclic and Tetracyclic Quinuclidine Derivatives by Cycloaddition and Ring Transformation." Zeitschrift für Naturforschung B 61, no. 1 (2006): 93–100. http://dx.doi.org/10.1515/znb-2006-0119.

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The (Z)-2-arylidene-quinuclidines 5 - 8 were synthesized. Their reaction with aliphatic dibasic functional reagents in both basic and acidic conditions afforded the fused heterocycles 9, 10 and 11. However, the reaction of arylidene derivative 5 with an aromatic dibasic functional reagent gave benzimidazole 13 in lieu of the anticipated tetracyclic system, quinuclidino[3,2-e]benzo[b]-1,4-diazepine 12. Cycloadditions of 5 with different reagents gave the heterocyclic derivatives 17, 19, 22 and 23. Acid-catalyzed cyclization of 5 with excess resorcinol gave 24. Compounds 9a, 19 and 24 showed ant

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Nagy, Fehér, Dargó, et al. "Comparison of Cinchona Catalysts Containing Ethyl or Vinyl or Ethynyl Group at Their Quinuclidine Ring." Materials 12, no. 18 (2019): 3034. http://dx.doi.org/10.3390/ma12183034.

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Numerous cinchona organocatalysts with different substituents at their quinuclidine unit have been described and tested, but the effect of those saturation has not been examined before. This work presents the synthesis of four widely used cinchona-based organocatalyst classes (hydroxy, amino, squaramide, and thiourea) with different saturation on the quinuclidine unit (ethyl, vinyl, ethynyl) started from quinine, the most easily available cinchona derivative. Big differences were found in basicity of the quinuclidine unit by measuring the pKa values of twelve catalysts in six solvents. The eff

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O’Neil, Ian A., James Hitchin, Inder Bhamra, Alan P. Chorlton, and David J. Tapolczay. "Directed lithiation on the quinuclidine ring system: the synthesis of 2,3-difunctionalised quinuclidines." Tetrahedron Letters 49, no. 52 (2008): 7416–18. http://dx.doi.org/10.1016/j.tetlet.2008.10.064.

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Hartwig, Uwe, Hans Pritzkow, Wolfgang Sundermeyer, and Joachim Waldi. "Synthese und Struktur eines aminstabilisierten Sulfens, RHC=SO2 · N(CH2CH2)3CH / Synthesis and Structure of an Amine Stabilized Sulfene, RHC=SO2 · N(CH2CH2)3CH." Zeitschrift für Naturforschung B 43, no. 3 (1988): 271–74. http://dx.doi.org/10.1515/znb-1988-0306.

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The structure of the quinuclidine-stabilized mesyl sulfene H3C-SO2-CH=SO2←N(CH2CH2)3CH (3) was determined by X-ray analysis, which indicates a double-bond in the C=SO2 group, while the quinuclidine is coordinated at a distance to the sulfur atom longer than a S-N single bond.

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Dinnocenzo, J. P., and T. E. Banach. "Quinuclidine dimer cation radical." Journal of the American Chemical Society 110, no. 3 (1988): 971–73. http://dx.doi.org/10.1021/ja00211a050.

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L. Stotter, Philip, Martin D. Friedman, Gordon O. Dorsey, Robert W. Shiely, Robert F. Williams, and David E. Minter. "Quinuclidine∑boranes as Intermediates in Formation and Isolation of Functionalized Quinuclidine Systems." HETEROCYCLES 25, no. 1 (1987): 251. http://dx.doi.org/10.3987/s-1987-01-0251.

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Da Silva Goes, Alexandre J., Christian Cavé, and Jean d'Angelo. "Stereocontrolled approach to quinuclidine derivatives." Tetrahedron Letters 39, no. 11 (1998): 1339–40. http://dx.doi.org/10.1016/s0040-4039(97)10812-7.

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Cammerer, Simon B., Carmen Jimenez, Simon Jones, et al. "Quinuclidine Derivatives as Potential Antiparasitics." Antimicrobial Agents and Chemotherapy 51, no. 11 (2007): 4049–61. http://dx.doi.org/10.1128/aac.00205-07.

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ABSTRACT There is an urgent need for the development of new drugs for the treatment of tropical parasitic diseases such as Chagas' disease and leishmaniasis. One potential drug target in the organisms that cause these diseases is sterol biosynthesis. This paper describes the design and synthesis of quinuclidine derivatives as potential inhibitors of a key enzyme in sterol biosynthesis, squalene synthase (SQS). A number of compounds that were inhibitors of the recombinant Leishmania major SQS at submicromolar concentrations were discovered. Some of these compounds were also selective for the pa

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Dissertations / Theses on the topic "Quinuclidine"

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Giles, Sally Louise. "New aspects of quinuclidine chemistry." Thesis, University of Liverpool, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272725.

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Taylor, Nicholas. "Borane transfer reactions." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/22027.

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Lewis base borane adducts (LB·BH3) constitute a well-known class of molecules with a number of diverse applications, including use as protected phosphines. The kinetics and thermodynamics of borane transfer reactions from a wide range of Lewis base borane complexes have been studied. The data generated has been used both as a quantitative tool to describe the nucleofugality (leaving group ability) of Lewis bases and as a means to improve the efficiency of phosphine borane deprotection reactions. The kinetics of borane transfer from a range of tertiary phosphine borane complexes to a wide range

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Sulaman, Mohammad Irfan. "New quinuclidine based reagents and their application in organic synthesis." Thesis, University of Liverpool, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540012.

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Wynn, Duncan George. "Investigations into the reactions and chemistry of quinuclidine N-oxides and related molecules." Thesis, University of Liverpool, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.402355.

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Hazm, Jamal Eddine. "Silicates et aluminosilicates microporeux obtenus en milieu fluoré avec, comme structurants, le 1,4-diazabicyclo [2,2,2] octane (DABCO) ou le 1-azabicyclo [2,2,2] octane (quinuclidine)." Mulhouse, 1992. http://www.theses.fr/1992MULH0238.

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Ce travail s'inscrit dans le cadre de l'exploration d'une nouvelle voie de synthèse hydrothermale des zéolithes. L'ion mobilisateur hydroxyde habituellement utilisé est ici remplacé par l'ion fluorure, avec pour corollaire l'emploi de milieux de synthèse de pH typiquement compris entre environ 7 et 10. L'utilisation de 2 structurants organiques différents, le 1,4-diazabicyclo [2,2,2] octane (« DABCO » ou le 1-azabicyclo [2,2,2] octane (« quinuclidine ») - combiné à des rapports molaires Si/Al variables - a permis respectivement la préparation des zéolithes bêta et de type MTW d'une part, ainsi

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Piant, Sébastien. "Nanostructuration de groupements protecteurs photolabiles sensibles à l'excitation bi-photonique pour les neurosciences." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAF062/document.

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Les groupements protecteurs photolabiles sont utilisés pour de nombreuses applications, notamment en neuroscience pour la libération de neurotransmetteurs avec un contrôle spatio-temporel très fin. La démocratisation des lasers pulsés infrarouges a permis la mise au point de nouveaux composés sensibles à l’excitation à deux photons, de plus en plus efficace. Cependant, l’ingénierie moléculaire des cages n’est pas la seule méthode qui peut être utilisée pour améliorer l’efficacité des de ces composés. Mon travail de thèse a ainsi abordé cette problématique sous l’angle de la nanostructuration d

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Gibbons, Peter David. "The synthesis of polyfunctionalised quinuclidines." Thesis, University of Liverpool, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415657.

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Hitchin, James Richard. "The synthesis and application of functionalised quinuclidines." Thesis, University of Liverpool, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426128.

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Greenhough, Richard John. "The synthesis of functionalised quinuclidines and their application in organic synthesis." Thesis, University of Liverpool, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.479030.

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Paterson, David S. "Imaging cholinergic function in vivo in the brain with radioiodinated stereoisomers of quinuclidinyl benzilate." Thesis, University of Glasgow, 1998. http://theses.gla.ac.uk/3755/.

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This thesis evaluates the ability of (R,S)- and (R,R)-[125I]-QNB, two radioiodinated diastereoisomers of the high affinity muscarinic antagonist quinuclidinyl benzilate (QNB), to image dynamic changes in cholinergic function in the central nervous system using in vivo autoradiography. The regional uptake and retention of (R,S)-[125I]-QNB in the rat brain between 2 and 24 hours after intravenous administration was investigated to assess the utility of this technique to image muscarinic receptors in the central nervous system. Similarly, the uptake and retention of (R,R)-[125I]-QNB was investiga

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Book chapters on the topic "Quinuclidine"

1

Holze, Rudolf. "Ionic conductivities of 1-hexyl-quinuclidine-TFSI ionic liquid." In Electrochemistry. Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-642-02723-9_705.

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Maliniak, A., and J. Kowalewski. "Nuclear Spin Relaxation Study of Weak Molecular Interactions in Benzene Solutions of Quinuclidine." In Advanced Magnetic Resonance Techniques in Systems of High Molecular Complexity. Birkhäuser Boston, 1986. http://dx.doi.org/10.1007/978-1-4615-8521-3_10.

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Fisher, Abraham, and Eliahu Heldman. "(+)-Cis-Methyl-Spiro(1,3-Oxathiolane-5,3′)Quinuclidine (AF102B): A New M1 Agonist as a Rational Treatment Strategy in Alzheimer’s Disease - An Overview." In Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases. Springer US, 1990. http://dx.doi.org/10.1007/978-1-4684-5847-3_67.

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Rabey, J. M., E. Grynberg, and E. Graff. "The Value of Cholinergic Receptors in Blood Lymphocytes Measured by (3H)Quinuclidinyl Benzilate(3H)QNB for the Diagnosis of Cholinergic Related Dementia." In Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases. Springer US, 1990. http://dx.doi.org/10.1007/978-1-4684-5847-3_6.

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Treacy, M. M. J., and J. B. Higgins. "Quinuclidine AIPO-22." In Collection of Simulated XRD Powder Patterns for Zeolites. Elsevier, 2007. http://dx.doi.org/10.1016/b978-044453067-7/50504-9.

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Treacy, M. M. J., J. B. Higgins, and John B. Higgins. "Quinuclidine AIPO-16." In Collection of Simulated XRD Powder Patterns for Zeolites. Elsevier, 2001. http://dx.doi.org/10.1016/b978-044450702-0/50027-7.

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Treacy, M. M. J., J. B. Higgins, and John B. Higgins. "Quinuclidine AIPO-22." In Collection of Simulated XRD Powder Patterns for Zeolites. Elsevier, 2001. http://dx.doi.org/10.1016/b978-044450702-0/50036-8.

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Treacy, M. M. J., and J. B. Higgins. "Quinuclidine AIPO-16." In Collection of Simulated XRD Powder Patterns for Zeolites. Elsevier, 2007. http://dx.doi.org/10.1016/b978-044453067-7/50495-0.

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Milsom, Alexandra. "Quinuclidinyl Benzilate." In xPharm: The Comprehensive Pharmacology Reference. Elsevier, 2007. http://dx.doi.org/10.1016/b978-008055232-3.62503-6.

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Jabbour, R. E., and H. Salem. "BZ (3-Quinuclidinyl Benzilate)." In Encyclopedia of Toxicology. Elsevier, 2014. http://dx.doi.org/10.1016/b978-0-12-386454-3.00592-3.

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Conference papers on the topic "Quinuclidine"

1

Korppi-Tommola, Jouko E., Aulis Hakkarainen, and Vesa M. Helenius. "Molecular aggregates of quinuclidine and chlorophyll a." In Moscow - DL tentative, edited by Sergei A. Akhmanov and Marina Y. Poroshina. SPIE, 1991. http://dx.doi.org/10.1117/12.57312.

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Christie, D. J., H. Diaz-Arauzo, and J. M. Cook. "REACTIONS OF DRUG-DEPENDENT ANTIBODIES WITH METABOLITES OF QUININE (Qn) AND QUINIDINE (Qd)." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644578.

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In many cases of drug-induced immunologic thrombocytopenia (DITP), a metabolite, rather than the native drug, is suspected of provoking the destructive drug-dependent antibodies (DDAB) responsible for this severe hemorrhagic disorder. However, this has not previously been investigated for Qn- and Qd-DDAB. We report evidence that the native drugs, and not their metabolites, are the provocative agents in Qn and Qd DITP. Reactions of Qn- and Qd-DDAB with platelets were studied with the native drugs and four of their metabolites: the N-oxide and 10,11-diol derivatives (quinuclidine ring modificati

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Primozic, Ines, Marijana Bolant, Alma Ramic, and Srdjanka Tomic. "Preparation of novel meta and para substituted N-benzyl protected quinuclidine esters and their resolution with butyrylcholinesterase." In The 15th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2011. http://dx.doi.org/10.3390/ecsoc-15-00740.

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Obliosca, Judy M., Fan-Gang Tseng, Ching-Mao Huang, Leu-Wei Lo, and Pen-Cheng Wang. "Ligand-exchange of TOPO-capped CdSe quantum dots with quinuclidines." In 2012 7th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS). IEEE, 2012. http://dx.doi.org/10.1109/nems.2012.6196789.

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