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Journal articles on the topic 'Quorum Sensing Interference'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

González, Juan E., and Neela D. Keshavan. "Messing with Bacterial Quorum Sensing." Microbiology and Molecular Biology Reviews 70, no. 4 (2006): 859–75. http://dx.doi.org/10.1128/mmbr.00002-06.

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SUMMARY Quorum sensing is widely recognized as an efficient mechanism to regulate expression of specific genes responsible for communal behavior in bacteria. Several bacterial phenotypes essential for the successful establishment of symbiotic, pathogenic, or commensal relationships with eukaryotic hosts, including motility, exopolysaccharide production, biofilm formation, and toxin production, are often regulated by quorum sensing. Interestingly, eukaryotes produce quorum-sensing-interfering (QSI) compounds that have a positive or negative influence on the bacterial signaling network. This euk

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2

Zhang, Lian-Hui, and Yi-Hu Dong. "Quorum sensing and signal interference: diverse implications." Molecular Microbiology 53, no. 6 (2004): 1563–71. http://dx.doi.org/10.1111/j.1365-2958.2004.04234.x.

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Nalca, Yusuf, Lothar Jänsch, Florian Bredenbruch, Robert Geffers, Jan Buer, and Susanne Häussler. "Quorum-Sensing Antagonistic Activities of Azithromycin in Pseudomonas aeruginosa PAO1: a Global Approach." Antimicrobial Agents and Chemotherapy 50, no. 5 (2006): 1680–88. http://dx.doi.org/10.1128/aac.50.5.1680-1688.2006.

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ABSTRACT The administration of macrolides such as azithromycin for chronic pulmonary infection of cystic fibrosis patients has been reported to be of benefit. Although the mechanisms of action remain obscure, anti-inflammatory effects as well as interference of the macrolide with Pseudomonas aeruginosa virulence factor production have been suggested to contribute to an improved clinical outcome. In this study we used a systematic approach and analyzed the impact of azithromycin on the global transcriptional pattern and the protein expression profile of P. aeruginosa PAO1 cultures versus those

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García-Contreras, Rodolfo, Toshinari Maeda, and Thomas K. Wood. "Can resistance against quorum-sensing interference be selected?" ISME Journal 10, no. 1 (2015): 4–10. http://dx.doi.org/10.1038/ismej.2015.84.

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GHOSH, DHRITISHREE, MADHUPA SETH, PRIYAJIT MONDAL, and SUBHRA KANTI MUKHOPADHYAY. "Bacterial biofilms: role of quorum sensing and quorum quenching." Journal of Experimental Biology and Agricultural Sciences 10, no. 2 (2022): 278–93. http://dx.doi.org/10.18006/2022.10(2).278.293.

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Bacterial biofilms provide an adjustable strategy to manage themselves in the existing conditions. Biofilms of pathogenic bacteria act as a reservoir for various device and non-device related diseases which are tough to cure. Exposure to a high dose of antibiotics is not an appropriate solution to this problem as high antibiotic concentrations lead to the generation of Multi-drug resistant strains as well as affect the human body. So, it is needed to bypass the use of antibiotics to prevent bacterial biofilms. In this context, Quorum Sensing (QS) may be a potential target since biofilm formati

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Biradar, Baswaraj, and Prapulla Devi. "Quorum Sensing in Plaque Biofilms: Challenges and Future Prospects." Journal of Contemporary Dental Practice 12, no. 6 (2011): 479–85. http://dx.doi.org/10.5005/jp-journals-10024-1080.

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ABSTRACT Aim This review intends to provide a brief overview regarding quorum sensing among bacteria in biofilms and also attempts to throw light on the new research focusing on interference with the quorum sensing. Background Dental plaque is an example of microbial biofilm leading to periodontal disease and dental caries. Quorum sensing is widely employed by a variety of gram-positive and gram-negative bacterial species to coordinate various activities in biofilms. Quorum-sensing-interfering compounds have either a positive or a negative effect on the expression of bacterial phenotypes regul

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Wright, J. S., R. Jin, and R. P. Novick. "Transient interference with staphylococcal quorum sensing blocks abscess formation." Proceedings of the National Academy of Sciences 102, no. 5 (2005): 1691–96. http://dx.doi.org/10.1073/pnas.0407661102.

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8

McDougald, Diane, Scott A. Rice, and Staffan Kjelleberg. "Bacterial quorum sensing and interference by naturally occurring biomimics." Analytical and Bioanalytical Chemistry 387, no. 2 (2006): 445–53. http://dx.doi.org/10.1007/s00216-006-0761-2.

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9

Varga, Zoltán, Mira Szabó, Monika Kerényi, and Joseph Molnár. "Interference in quorum sensing signal transmission amongst microbial species." Acta Microbiologica et Immunologica Hungarica 59, no. 4 (2012): 475–84. http://dx.doi.org/10.1556/amicr.59.2012.4.5.

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Prabhavathi, S. Jaya, K. Subrahmaniyan, M. Senthil Kumar, G. Gayathry, and G. Malathi. "Exploring the Antibacterial, Anti-Biofilm, and Anti-Quorum Sensing Properties of Honey: A Comprehensive Review." Agriculture Archives 2, no. 3 (2023): 10–14. http://dx.doi.org/10.51470/agri.2023.2.3.10.

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Honey, a natural product derived from floral nectar and processed by bees, has long been recognized for its therapeutic properties. In recent years, extensive research has focused on exploring the antibacterial, anti-biofilm, and anti-quorum sensing activities of honey. This comprehensive review aims to summarize and analyze the current state of knowledge regarding the diverse antimicrobial properties of honey, with a particular emphasis on its effectiveness against bacterial infections, biofilm formation, and quorum sensing mechanisms. The review discusses the chemical composition of honey, i

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11

Chane, Andrea, Corinne Barbey, Magalie Robert, et al. "Biocontrol of Soft Rot: Confocal Microscopy Highlights Virulent Pectobacterial Communication and Its Jamming by Rhodococcal Quorum-Quenching." Molecular Plant-Microbe Interactions® 32, no. 7 (2019): 802–12. http://dx.doi.org/10.1094/mpmi-11-18-0314-r.

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Confocal laser-scanning microscopy was chosen to observe the colonization and damage caused by the soft rot Pectobacterium atrosepticum and the protection mediated by the biocontrol agent Rhodococcus erythropolis. We developed dual-color reporter strains suited for monitoring quorum-sensing and quorum-quenching activities leading to maceration or biocontrol, respectively. A constitutively expressed cyan or red fluorescent protein served as a cell tag for plant colonization, while an inducible expression reporter system based on the green fluorescent protein gene enabled the simultaneous record

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12

Kaufmann, Gunnar F., Rafaella Sartorio, Sang-Hyeup Lee, et al. "Antibody Interference withN-Acyl Homoserine Lactone-Mediated Bacterial Quorum Sensing." Journal of the American Chemical Society 128, no. 9 (2006): 2802–3. http://dx.doi.org/10.1021/ja0578698.

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13

Defoirdt, Tom. "Interfering with Bacterial Signalling Mechanisms as a Novel Strategy to Control Diseases – Aquaculture as a Case Study." Bulletin des Séances - Mededelingen der Zittingen 65, no. 1 (2021): 75–93. https://doi.org/10.5281/zenodo.4604360.

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Bacterial pathogens are quickly developing resistance to all known antibiotics. As a result, antibiotic treatments become ineffective, and diseases caused by antibiotic-resistant bacteria are currently a major cause of death worldwide. Bacterial cell-to-cell signalling mechanisms (quorum sensing) control several phenotypes that are required by pathogens to infect their host. Therefore, interfering with these mechanisms is now intensively studied as a novel strategy to control bacterial diseases.

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14

Jaafar, Firas Nabeeh, Majid Ahmed AL-Bayati, Hadeel Kareem Musafer, Maan Abdul Azeez, and Zahraa Kareem Raheem. "Quorum Sensing and its Correlation with Virulence Factors." South Asian Research Journal of Pharmaceutical Sciences 4, no. 3 (2022): 60–69. http://dx.doi.org/10.36346/sarjps.2022.v04i03.003.

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Quorum sensing (QS) is cell to cell signaling mechanism that enables bacteria collectively control gene expression in response to their population density, or it is bacterial communicate with one another using chemical signals. There are three types of signaling molecules: Acyl-homoserinelactonase (AHLs), Auto-inducer peptides (AIPs) and Autoinducer-2 (AI-2). Q.S was first observed and described in bioluminescence bacterium V.fischeri.In V. fischeri, several kinds of quorum sensing system were identified. At first, lux system was found and regulates the luciferase operon and light production.

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Lima, Emília Maria França, Stephen C. Winans, and Uelinton Manoel Pinto. "Quorum sensing interference by phenolic compounds – A matter of bacterial misunderstanding." Heliyon 9, no. 7 (2023): e17657. http://dx.doi.org/10.1016/j.heliyon.2023.e17657.

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16

Gatta, Viviana, Polina Ilina, Alison Porter, Stuart McElroy, and Päivi Tammela. "Targeting Quorum Sensing: High-Throughput Screening to Identify Novel LsrK Inhibitors." International Journal of Molecular Sciences 20, no. 12 (2019): 3112. http://dx.doi.org/10.3390/ijms20123112.

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Since quorum sensing (QS) is linked to the establishment of bacterial infection, its inactivation represents one of the newest strategies to fight bacterial pathogens. LsrK is a kinase playing a key role in the processing of autoinducer-2 (AI-2), a quorum-sensing mediator in gut enteric bacteria. Inhibition of LsrK might thus impair the quorum-sensing cascade and consequently reduce bacterial pathogenicity. Aiming for the development of a target-based assay for the discovery of LsrK inhibitors, we evaluated different assay set-ups based on ATP detection and optimized an automation-compatible m

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Torres, Marta, Yves Dessaux, and Inmaculada Llamas. "Saline Environments as a Source of Potential Quorum Sensing Disruptors to Control Bacterial Infections: A Review." Marine Drugs 17, no. 3 (2019): 191. http://dx.doi.org/10.3390/md17030191.

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Saline environments, such as marine and hypersaline habitats, are widely distributed around the world. They include sea waters, saline lakes, solar salterns, or hypersaline soils. The bacteria that live in these habitats produce and develop unique bioactive molecules and physiological pathways to cope with the stress conditions generated by these environments. They have been described to produce compounds with properties that differ from those found in non-saline habitats. In the last decades, the ability to disrupt quorum-sensing (QS) intercellular communication systems has been identified in

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Higuera-Ciapara, Inocencio, Marieva Benitez-Vindiola, Luis J. Figueroa-Yañez, and Evelin Martínez-Benavidez. "Polyphenols and CRISPR as Quorum Quenching Agents in Antibiotic-Resistant Foodborne Human Pathogens (Salmonella Typhimurium, Campylobacter jejuni and Escherichia coli 0157:H7)." Foods 13, no. 4 (2024): 584. http://dx.doi.org/10.3390/foods13040584.

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Antibiotic resistance in foodborne pathogens is an increasing threat to global human health. Among the most prevalent antibiotic-resistant bacteria are Salmonella enterica serovar Typhimurium, Campylobacter jejuni and E. coli 0157:H7. Control of these and other pathogens requires innovative approaches, i.e., discovering new molecules that will inactivate them, or render them less virulent without inducing resistance. Recently, several polyphenol molecules have been shown to possess such characteristics. Also, the use of CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) approac

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Watve, Samit, Kelsey Barrasso, Sarah A. Jung, et al. "Parallel quorum-sensing system in Vibrio cholerae prevents signal interference inside the host." PLOS Pathogens 16, no. 2 (2020): e1008313. http://dx.doi.org/10.1371/journal.ppat.1008313.

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Williams, T. C., N. J. H. Averesch, G. Winter, et al. "Quorum-sensing linked RNA interference for dynamic metabolic pathway control in Saccharomyces cerevisiae." Metabolic Engineering 29 (May 2015): 124–34. http://dx.doi.org/10.1016/j.ymben.2015.03.008.

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21

Rampioni, Giordano, Livia Leoni, and Paul Williams. "The art of antibacterial warfare: Deception through interference with quorum sensing–mediated communication." Bioorganic Chemistry 55 (August 2014): 60–68. http://dx.doi.org/10.1016/j.bioorg.2014.04.005.

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22

Naik, Akshatha, Bhavya Jayanth Nirmala, Sandeep Kumar, Mahendra Gowdru Srinivasa, Revanasiddappa B C, and Ramya Premanath. "Interference of selected essential oils in modulating quorum sensing mechanism in Klebsiella pneumoniae." Microbial Pathogenesis 205 (August 2025): 107679. https://doi.org/10.1016/j.micpath.2025.107679.

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23

Arranz San Martín, Alba, Jan Vogel, Sandra C. Wullich, Wim J. Quax, and Susanne Fetzner. "Enzyme-Mediated Quenching of the Pseudomonas Quinolone Signal (PQS): A Comparison between Naturally Occurring and Engineered PQS-Cleaving Dioxygenases." Biomolecules 12, no. 2 (2022): 170. http://dx.doi.org/10.3390/biom12020170.

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The opportunistic pathogen Pseudomonas aeruginosa employs quorum sensing to govern the production of many virulence factors. Interference with quorum sensing signaling has therefore been put forward as an attractive approach to disarm this pathogen. Here, we analyzed the quorum quenching properties of natural and engineered (2-alkyl-)3-hydroxy-4(1H)-quinolone 2,4-dioxygenases (HQDs) that inactivate the P. aeruginosa signal molecule PQS (Pseudomonas quinolone signal; 2-heptyl-3-hydroxy-4(1H)-quinolone). When added exogenously to P. aeruginosa cultures, all HQDs tested significantly reduced the

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24

Weiland-Bräuer, Nancy, Nicole Pinnow, and Ruth A. Schmitz. "Novel Reporter for Identification of Interference with Acyl Homoserine Lactone and Autoinducer-2 Quorum Sensing." Applied and Environmental Microbiology 81, no. 4 (2014): 1477–89. http://dx.doi.org/10.1128/aem.03290-14.

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ABSTRACTTwo reporter strains were established to identify novel biomolecules interfering with bacterial communication (quorum sensing [QS]). The basic design of theseEscherichia coli-based systems comprises a gene encoding a lethal protein fused to promoters induced in the presence of QS signal molecules. Consequently, theseE. colistrains are unable to grow in the presence of the respective QS signal molecules unless a nontoxic QS-interfering compound is present. The first reporter strain designed to detect autoinducer-2 (AI-2)-interfering activities (AI2-QQ.1) contained theE. coliccdBlethal g

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Dong, Yi-Hu, Xi-Fen Zhang, Jin-Ling Xu, and Lian-Hui Zhang. "Insecticidal Bacillus thuringiensis Silences Erwinia carotovora Virulence by a New Form of Microbial Antagonism, Signal Interference." Applied and Environmental Microbiology 70, no. 2 (2004): 954–60. http://dx.doi.org/10.1128/aem.70.2.954-960.2004.

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ABSTRACT It is commonly known that bacteria may produce antibiotics to interfere with the normal biological functions of their competitors in order to gain competitive advantages. Here we report that Bacillus thuringiensis suppressed the quorum-sensing-dependent virulence of plant pathogen Erwinia carotovora through a new form of microbial antagonism, signal interference. E. carotovora produces and responds to acyl-homoserine lactone (AHL) quorum-sensing signals to regulate antibiotic production and expression of virulence genes, whereas B. thuringiensis strains possess AHL-lactonase, which is

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Srivastava, A., B. N. Singh, D. Deepak, A. K. S. Rawat, and B. R. Singh. "Colostrum Hexasaccharide, a Novel Staphylococcus aureus Quorum-Sensing Inhibitor." Antimicrobial Agents and Chemotherapy 59, no. 4 (2015): 2169–78. http://dx.doi.org/10.1128/aac.03722-14.

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ABSTRACTThe discovery of quorum-sensing (QS) systems regulating antibiotic resistance and virulence factors (VFs) has afforded a novel opportunity to prevent bacterial pathogenicity. Dietary molecules have been demonstrated to attenuate QS circuits of bacteria. But, to our knowledge, no study exploring the potential of colostrum hexasaccharide (CHS) in regulating QS systems has been published. In this study, we analyzed CHS for inhibiting QS signaling inStaphylococcus aureus. We isolated and characterized CHS from mare colostrum by high-performance thin-layer chromatography (HPTLC), reverse-ph

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Gunaratnam, Sathursha, Mathieu Millette, Lynne V. McFarland, Herbert L. DuPont, and Monique Lacroix. "Potential role of probiotics in reducing Clostridioides difficile virulence: Interference with quorum sensing systems." Microbial Pathogenesis 153 (April 2021): 104798. http://dx.doi.org/10.1016/j.micpath.2021.104798.

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28

Liu, Yiying, Qiwei Qin, and Tom Defoirdt. "Does quorum sensing interference affect the fitness of bacterial pathogens in the real world?" Environmental Microbiology 20, no. 11 (2018): 3918–26. http://dx.doi.org/10.1111/1462-2920.14446.

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Dulla, Glenn F. J., Ksenia V. Krasileva, and Steven E. Lindow. "Interference of quorum sensing in Pseudomonas syringae by bacterial epiphytes that limit iron availability." Environmental Microbiology 12, no. 6 (2010): 1762–74. http://dx.doi.org/10.1111/j.1462-2920.2010.02261.x.

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30

Hegazy, Wael A. H., Maan T. Khayat, Tarek S. Ibrahim, et al. "Repurposing Anti-diabetic Drugs to Cripple Quorum Sensing in Pseudomonas aeruginosa." Microorganisms 8, no. 9 (2020): 1285. http://dx.doi.org/10.3390/microorganisms8091285.

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Pseudomonas aeruginosa is a significant human pathogen, it possesses almost all of the known antimicrobial resistance mechanisms. Quorum sensing (QS) is an intercellular communication system that orchestrates bacterial virulence and its targeting is an effective approach to diminish its pathogenesis. Repurposing of drugs is an advantageous strategy, in this study we aimed to repurpose the anti-diabetic drugs sitagliptin, metformin and vildagliptin as anti-QS in P. aeruginosa. The effects of sub-inhibitory concentrations of the tested drugs on the expression of QS-encoding genes and QS-regulate

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Markus, Victor, Abraham Abbey Paul, Kerem Teralı, et al. "Conversations in the Gut: The Role of Quorum Sensing in Normobiosis." International Journal of Molecular Sciences 24, no. 4 (2023): 3722. http://dx.doi.org/10.3390/ijms24043722.

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An imbalance in gut microbiota, termed dysbiosis, has been shown to affect host health. Several factors, including dietary changes, have been reported to cause dysbiosis with its associated pathologies that include inflammatory bowel disease, cancer, obesity, depression, and autism. We recently demonstrated the inhibitory effects of artificial sweeteners on bacterial quorum sensing (QS) and proposed that QS inhibition may be one mechanism behind such dysbiosis. QS is a complex network of cell–cell communication that is mediated by small diffusible molecules known as autoinducers (AIs). Using A

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González-Ortiz, Gemma, H. C. Quarles Van Ufford, S. Bart A. Halkes, et al. "New properties of wheat bran: anti-biofilm activity and interference with bacteria quorum-sensing systems." Environmental Microbiology 16, no. 5 (2014): 1346–53. http://dx.doi.org/10.1111/1462-2920.12441.

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33

Hashimi, Amna Al. "Ultrasound-Mediated Attenuation of Quorum Sensing and Its Impact on Biofilm Structure." South Asian Research Journal of Applied Medical Sciences 7, no. 02 (2025): 51–59. https://doi.org/10.36346/sarjams.2025.v07i02.003.

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Bacteria use quorum sensing (QS) and biofilm formation as essential adaptation and persistence strategies in harsh settings, which contribute to the development of antibiotic resistance and persistent infections. Through signaling molecules, QS allows bacteria to coordinate group behaviors, and biofilms improve microbial resistance and offer structural protection. A potentially effective physical intervention for interfering with QS signaling and biofilm integrity is ultrasound. The modulation of QS pathways by ultrasound, including signaling molecule degradation and interference with QS recep

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Xu, Yijie, Chunlan Zeng, Huiqi Wen, et al. "Discovery of AI-2 Quorum Sensing Inhibitors Targeting the LsrK/HPr Protein–Protein Interaction Site by Molecular Dynamics Simulation, Virtual Screening, and Bioassay Evaluation." Pharmaceuticals 16, no. 5 (2023): 737. http://dx.doi.org/10.3390/ph16050737.

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Quorum sensing (QS) is a cell-to-cell communication mechanism that regulates bacterial pathogenicity, biofilm formation, and antibiotic sensitivity. Among the identified quorum sensing, AI-2 QS exists in both Gram-negative and Gram-positive bacteria and is responsible for interspecies communication. Recent studies have highlighted the connection between the phosphotransferase system (PTS) and AI-2 QS, with this link being associated with protein-protein interaction (PPI) between HPr and LsrK. Here, we first discovered several AI-2 QSIs targeting the LsrK/HPr PPI site through molecular dynamics

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Coelho, Patrícia, Joana Oliveira, Iva Fernandes, et al. "Pyranoanthocyanins Interfering with the Quorum Sensing of Pseudomonas aeruginosa and Staphylococcus aureus." International Journal of Molecular Sciences 22, no. 16 (2021): 8559. http://dx.doi.org/10.3390/ijms22168559.

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Bacterial quorum sensing (QS) is a cell-cell communication system that regulates several bacterial mechanisms, including the production of virulence factors and biofilm formation. Thus, targeting microbial QS is seen as a plausible alternative strategy to antibiotics, with potentiality to combat multidrug-resistant pathogens. Many phytochemicals with QS interference activity are currently being explored. Herein, an extract and a compound of bioinspired origin were tested for their ability to inhibit biofilm formation and interfere with the expression of QS-related genes in Pseudomonas aerugino

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Shevate, Shital N., Niranjan P. Patil, and Shobha A. Waghmode. "Synthesis and Evaluation of Quorum Quenching activity of Ag, TiO2 and ZnO metal nanoparticles against wild type and mutant strains of Chromobacterium violaceum." Research Journal of Chemistry and Environment 26, no. 8 (2022): 127–33. http://dx.doi.org/10.25303/2608rjce1270133.

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The conventional strategies to combat pathogenic microbes seem to be inefficient to curb the menace of pathogens. The bacterial biofilm is a product of the quorum sensing (QS) process mediated by acylhomoserine lactones (AHL) in many pathogens. The QS inhibitors or quorum quenching (QQ) molecules that disrupt bacterial communication offer an alternative promising strategy to lower antibiotic resistance in pathogens. The nanoparticles can exhibit QQ potential that interrupts cell-to-cell communication. In the present study, laboratory synthesized metal-based nanoparticles such as silver (Ag), t

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Riedel, Kathrin, Manuela Köthe, Bernd Kramer, et al. "Computer-Aided Design of Agents That Inhibit the cep Quorum-Sensing System of Burkholderia cenocepacia." Antimicrobial Agents and Chemotherapy 50, no. 1 (2006): 318–23. http://dx.doi.org/10.1128/aac.50.1.318-323.2006.

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ABSTRACT Recent research has provided evidence that interference with bacterial cell-to-cell signaling is a promising strategy for the development of novel antimicrobial agents. Here we report on the computer-aided design of novel compounds that specifically inhibit an N-acyl-homoserine lactone-dependent communication system that is widespread among members of the genus Burkholderia. This genus comprises more than 30 species, many of which are important pathogens of animals and humans. Over the past few years, several Burkholderia species, most notably Burkholderia cenocepacia, have emerged as

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Joshi, Janak Raj, Netaly Khazanov, Amy Charkowski, Adi Faigenboim, Hanoch Senderowitz, and Iris Yedidia. "Interkingdom Signaling Interference: The Effect of Plant-Derived Small Molecules on Quorum Sensing in Plant-Pathogenic Bacteria." Annual Review of Phytopathology 59, no. 1 (2021): 153–90. http://dx.doi.org/10.1146/annurev-phyto-020620-095740.

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In the battle between bacteria and plants, bacteria often use a population density–dependent regulatory system known as quorum sensing (QS) to coordinate virulence gene expression. In response, plants use innate and induced defense mechanisms that include low-molecular-weight compounds, some of which serve as antivirulence agents by interfering with the QS machinery. The best-characterized QS system is driven by the autoinducer N-acyl-homoserine lactone (AHL), which is produced by AHL synthases (LuxI homologs) and perceived by response regulators (LuxR homologs). Several plant compounds have b

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Zhang, Hua, Zhen Zhang, Jing Li, and Guangyong Qin. "New Strategies for Biocontrol of Bacterial Toxins and Virulence: Focusing on Quorum-Sensing Interference and Biofilm Inhibition." Toxins 15, no. 9 (2023): 570. http://dx.doi.org/10.3390/toxins15090570.

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The overuse of antibiotics and the emergence of multiple-antibiotic-resistant pathogens are becoming a serious threat to health security and the economy. Reducing antimicrobial resistance requires replacing antibiotic consumption with more biocontrol strategies to improve the immunity of animals and humans. Probiotics and medicinal plants have been used as alternative treatments or preventative therapies for a variety of diseases caused by bacterial infections. Therefore, we reviewed some of the anti-virulence and bacterial toxin-inhibiting strategies that are currently being developed; this r

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Cho, Hyun-Soo, Soo-Young Park, Choong-Min Ryu, Jihyun F. Kim, Jong-Guk Kim, and Seung-Hwan Park. "Interference of quorum sensing and virulence of the rice pathogen Burkholderia glumae by an engineered endophytic bacterium." FEMS Microbiology Ecology 60, no. 1 (2007): 14–23. http://dx.doi.org/10.1111/j.1574-6941.2007.00280.x.

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Gatta, Viviana, Tihomir Tomašič, Janez Ilaš, et al. "A New Cell‐Based AI‐2‐Mediated Quorum Sensing Interference Assay in Screening of LsrK‐Targeted Inhibitors." ChemBioChem 21, no. 13 (2020): 1918–22. http://dx.doi.org/10.1002/cbic.201900773.

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42

Soto, Sara M. "Importance of Biofilms in Urinary Tract Infections: New Therapeutic Approaches." Advances in Biology 2014 (July 2, 2014): 1–13. http://dx.doi.org/10.1155/2014/543974.

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Bacterial biofilms play an important role in urinary tract infections (UTIs), being responsible for persistence infections causing relapses and acute prostatitis. Bacterial forming biofilm are difficult to eradicate due to the antimicrobial resistant phenotype that this structure confers being combined therapy recommended for the treatment of biofilm-associated infections. However, the presence of persistent cells showing reduced metabolism that leads to higher levels of antimicrobial resistance makes the search for new therapeutic tools necessary. Here, a review of these new therapeutic appro

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Tao, Chen, Qian Guo-Liang, Yang Xiao-Li, Ma Jun-Yi, Hu Bai-Shi, and Liu Feng-Quan. "Detection of a quorum sensing signal molecule of Acidovorax avenae subsp. citrulli and its regulation of pathogenicity." Chinese Journal of Agricultural Biotechnology 6, no. 1 (2009): 49–53. http://dx.doi.org/10.1017/s1479236209002514.

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AbstractAn efficient AHL (N-acyl-homoserine lactone) bioassay strain, JZA1, of Agrobacterium tumefaciens was used to detect the AHL production from Acidovorax avenae subsp. citrulli [the pathogen causing bacterial fruit blotch (BFB) of melons], and the results showed that A. avenae subsp. citrulli produced a 3-O-C8-homoserine (HSL) type signal molecule. Gene aiiA, which could degrade AHL molecules, was transformed into A. avenae subsp. citrulli strain NJF10, creating strain NJF10-aiiA. The AHL production from NJF10-aiiA was significantly reduced compared with wild-type NJF10. Inoculation tests

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Subhadra, Bindu, Dong Kim, Kyungho Woo, Surya Surendran, and Chul Choi. "Control of Biofilm Formation in Healthcare: Recent Advances Exploiting Quorum-Sensing Interference Strategies and Multidrug Efflux Pump Inhibitors." Materials 11, no. 9 (2018): 1676. http://dx.doi.org/10.3390/ma11091676.

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Biofilm formation in healthcare is an issue of considerable concern, as it results in increased morbidity and mortality, imposing a significant financial burden on the healthcare system. Biofilms are highly resistant to conventional antimicrobial therapies and lead to persistent infections. Hence, there is a high demand for novel strategies other than conventional antibiotic therapies to control biofilm-based infections. There are two approaches which have been employed so far to control biofilm formation in healthcare settings: one is the development of biofilm inhibitors based on the underst

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Wang, Wenting, Dongxiang Li, Xiaoqin Huang, et al. "Study on Antibacterial and Quorum-Sensing Inhibition Activities of Cinnamomum camphora Leaf Essential Oil." Molecules 24, no. 20 (2019): 3792. http://dx.doi.org/10.3390/molecules24203792.

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Many essential oils (EOs) regulate the quorum-sensing (QS) system of pathogens and inhibit the virulence expression. Interference with QS can potentially reduce bacterial multidrug resistance and aid the biological control of bacterial disease. In the present work, the antibacterial and anti-QS activities of Cinnamomum camphora leaf EO were investigated. A total of 23 chemical components with relative levels ≥0.11%, including a large number of terpene compounds, were identified in C. camphora leaf EO by gas chromatography–mass spectrometry (GC-MS). The principal component was linalool, followe

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Spieß, Tobias, Sophie Marianne Korn, Peter Kötter, and Karl-Dieter Entian. "Activation of Histidine Kinase SpaK Is Mediated by the N-Terminal Portion of Subtilin-Like Lantibiotics and Is Independent of Lipid II." Applied and Environmental Microbiology 81, no. 16 (2015): 5335–43. http://dx.doi.org/10.1128/aem.01368-15.

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ABSTRACTThe biosynthesis of the lantibiotic subtilin is autoinduced in a quorum-sensing mechanism via histidine kinase SpaK. Subtilin-like lantibiotics, such as entianin, ericin S, and subtilin, specifically activated SpaK in a comparable manner, whereas the structurally similar nisin did not provide the signal for SpaK activation at nontoxic concentrations. Surprisingly, nevertheless, nisin if applied together with entianin partly quenched SpaK activation. The N-terminal entianin1–20fragment (comprising N-terminal amino acids 1 to 20) was sufficient for SpaK activation, although higher concen

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Deng, Yinyue, Calvin Boon, Shaohua Chen, Amy Lim, and Lian-Hui Zhang. "Cis-2-dodecenoic acid signal modulates virulence of Pseudomonas aeruginosa through interference with quorum sensing systems and T3SS." BMC Microbiology 13, no. 1 (2013): 231. http://dx.doi.org/10.1186/1471-2180-13-231.

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Jose, Polpass Arul, Ramasamy Krishnamoorthy, Soon-Wo Kwon, et al. "Interference in quorum sensing and virulence of the phytopathogen Pseudomonas syringae pv. passiflorae by Bacillus and Variovorax species." BioControl 64, no. 4 (2019): 423–33. http://dx.doi.org/10.1007/s10526-019-09932-6.

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Xu, Huijie, Yu Yang, Tian Xia, et al. "Overlooked interference of antibiotics on quorum sensing inhibitors for membrane biofouling mitigation by affecting AHLs and PQS pathway." Separation and Purification Technology 363 (August 2025): 132116. https://doi.org/10.1016/j.seppur.2025.132116.

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Ye, Tian, Tian Zhou, Qiting Li, et al. "Cupriavidus sp. HN-2, a Novel Quorum Quenching Bacterial Isolate, is a Potent Biocontrol Agent Against Xanthomonas campestris pv. campestris." Microorganisms 8, no. 1 (2019): 45. http://dx.doi.org/10.3390/microorganisms8010045.

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Diffusible signal factor (DSF) represents a family of widely conserved quorum sensing (QS) signals involved in the regulation of virulence factor production in many Gram-negative bacterial pathogens. Quorum quenching, which disrupts QS either by degradation of QS signals or interference of signal generation or perception, is a promising strategy for prevention and control of QS-mediated bacterial infections. In this study, a novel DSF-degrading strain, HN-2, was isolated from contaminated soil and identified as Cupriavidus sp. The isolate exhibited superior DSF degradation activity and complet

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