Relevant bibliographies by topics / (R)-[11C]PK11195

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic '(R)-[11C]PK11195'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "(R)-[11C]PK11195"

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Kobayashi, Masato, Teresa Jiang, Sanjay Telu, et al. "11C-DPA-713 has much greater specific binding to translocator protein 18 kDa (TSPO) in human brain than 11C-(R)-PK11195." Journal of Cerebral Blood Flow & Metabolism 38, no. 3 (2017): 393–403. http://dx.doi.org/10.1177/0271678x17699223.

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Positron emission tomography (PET) radioligands for translocator protein 18 kDa (TSPO) are widely used to measure neuroinflammation, but controversy exists whether second-generation radioligands are superior to the prototypical agent 11C-( R)-PK11195 in human imaging. This study sought to quantitatively measure the “signal to background” ratio (assessed as binding potential ( BPND)) of 11C-( R)-PK11195 compared to one of the most promising second-generation radioligands, 11C-DPA-713. Healthy subjects had dynamic PET scans and arterial blood measurements of radioligand after injection of either
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Alfaifi, B., E. Agushi, R. Hinz, A. Jackson, D. Lewis, and D. Coope. "P15.10.A USE OF DUAL TRACERS PET AS A PREDICTIVE BIOMARKER OF THE SITE OF RECURRENCE IN HIGH GRADE GLIOMA." Neuro-Oncology 25, Supplement_2 (2023): ii111—ii112. http://dx.doi.org/10.1093/neuonc/noad137.374.

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Abstract BACKGROUND High grade glioma has poor survival rate and tumour recurrence occurs despite current treatments. Positron emission tomography (PET) with [11C](R)PK11195 can evaluate translocator protein (TSPO) and [11C]methionine can assess amino acid transport. PET imaging might have the potential to detect tumour regions at baseline that will later develop as the site of recurrence. We compare TSPO measured using [11C](R)PK11195 and amino acid transport using [11C]methionine at baseline and investigate to what extend the two tracers can predict the site of tumour recurrence. MATERIAL AN
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Bitker, Laurent, Nicolas Costes, Didier Le Bars, et al. "Noninvasive quantification of macrophagic lung recruitment during experimental ventilation-induced lung injury." Journal of Applied Physiology 127, no. 2 (2019): 546–58. http://dx.doi.org/10.1152/japplphysiol.00825.2018.

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Macrophagic lung infiltration is pivotal in the development of lung biotrauma because of ventilation-induced lung injury (VILI). We assessed the performance of [11C](R)-PK11195, a positron emission tomography (PET) radiotracer binding the translocator protein, to quantify macrophage lung recruitment during experimental VILI. Pigs ( n = 6) were mechanically ventilated under general anesthesia, using protective ventilation settings (baseline). Experimental VILI was performed by titrating tidal volume to reach a transpulmonary end-inspiratory pressure (∆PL) of 35–40 cmH2O. We acquired PET/compute
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de Souza, Aline Morais, Caroline Cristiano Real, Mara de Souza Junqueira, et al. "Potential of [11C](R)-PK11195 PET Imaging for Evaluating Tumor Inflammation: A Murine Mammary Tumor Model." Pharmaceutics 14, no. 12 (2022): 2715. http://dx.doi.org/10.3390/pharmaceutics14122715.

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Background: Breast tumor inflammation is an immunological process that occurs mainly by mediation of Tumor-Associated Macrophages (TAM). Aiming for a specific measurement of tumor inflammation, the current study evaluated the potential of Positron Emission Tomography (PET) imaging with [11C](R)-PK11195 to evaluate tumor inflammation in a mammary tumor animal model. Methods: Female Balb/C mice were inoculated with 4T1 cells. The PET imaging with [11C](R)-PK11195 and [18F]FDG was acquired 3 days, 1 week, and 2 weeks after cell inoculation. Results: The [11C](R)-PK11195 tumor uptake increased fro
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Su, Zhangjie, Federico Roncaroli, Pascal F. Durrenberger, et al. "The 18-kDa Mitochondrial Translocator Protein in Human Gliomas: A 11C-(R)PK11195 PET Imaging and Neuropathology Study." Journal of Nuclear Medicine 56, no. 4 (2015): 512–7. https://doi.org/10.2967/jnumed.114.151621.

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The 18-kDa mitochondrial translocator protein (TSPO) is up-regulated in high grade astrocytomas and can be imaged by positron emission tomography (PET) using the selective radiotracer 11C-(R)PK11195. We investigated 11C-(R)PK11195 binding in human gliomas and its relationship with TSPO expression in tumor tissue and glioma associated microglia/macrophages within the tumors. METHODS: Twenty-two glioma patients underwent dynamic 11C-(R)PK11195 PET scans and perfusion MRI acquisition. Parametric maps of 11C-(R)PK11195 binding potential (BPND) were generated. Co-registered
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Yokokura, Masamichi, Tatsuhiro Terada, Tomoyasu Bunai, et al. "Depiction of microglial activation in aging and dementia: Positron emission tomography with [11C]DPA713 versus [11C](R)PK11195." Journal of Cerebral Blood Flow & Metabolism 37, no. 3 (2016): 877–89. http://dx.doi.org/10.1177/0271678x16646788.

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The presence of activated microglia in the brains of healthy elderly people is a matter of debate. We aimed to clarify the degree of microglial activation in aging and dementia as revealed by different tracers by comparing the binding potential (BPND) in various brain regions using a first-generation translocator protein (TSPO) tracer [11C]( R)PK11195 and a second-generation tracer [11C]DPA713. The BPND levels, estimated using simplified reference tissue models, were compared among healthy young and elderly individuals and patients with Alzheimer’s disease (AD) and were correlated with clinica
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Schuck, Phelipi Nunes, Caroline Machado Dartora, and Ana Maria Marques da Silva. "Geração de Imagens PET Estáticas com [11C]-(R)-PK11195: Definição do Intervalo Temporal." Revista Brasileira de Física Médica 11, no. 2 (2017): 25. http://dx.doi.org/10.29384/rbfm.2017.v11.n2.p25-29.

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O radiotraçador [11C]-(R)-PK11195 mostra afinidade com a microglia em imagens PET in vivo e vem sendo utilizado como indicador de doença inflamatória cerebral, como a esclerose múltipla (EM). Atualmente, não há consenso sobre o intervalo temporal adequado para gerar imagens PET estáticas com [11C]-(R)-PK11195. O objetivo deste trabalho é determinar o intervalo temporal mais adequado para a geração de imagens PET cerebrais estáticas adquiridas com [11C]-(R)-PK11195 para a quantificação. Foram geradas imagens PET estáticas com [11C]-(R)-PK11195 nos intervalos de: 0-60min, 5-20min, 5-30min, 10-60
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Boutin, Hervé, Katie Murray, Jesus Pradillo, et al. "[18F]GE-180: a novel TSPO radiotracer compared to [11C]PK11195 in a preclinical model of stroke." Eur J Nucl Med Mol Imaging 42, no. 3 (2014): 503–11. https://doi.org/10.1007/s00259-014-2939-8.

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PURPOSE: Neuroinflammation plays a critical role in various neuropathological conditions, and hence there is renewed interest in the translocator protein (TSPO) as a biomarker of microglial activation and macrophage infiltration in the brain. This is reflected in the large amount of research conducted seeking to replace the prototypical PET radiotracer 11C-R-PK11195 with a TSPO ligand with higher performance. Here we report the in vivo preclinical investigation of the novel TSPO tracer 18F-GE-180 in a rat model of stroke. METHODS: Focal cerebral ischaemia was induced in Wistar rats by 60-min o
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Gent, Yoony Y. J., Nazanin Ahmadi, Alexandre E. Voskuyl, et al. "Detection of Subclinical Synovitis with Macrophage Targeting and Positron Emission Tomography in Patients with Rheumatoid Arthritis without Clinical Arthritis." Journal of Rheumatology 41, no. 11 (2014): 2145–52. http://dx.doi.org/10.3899/jrheum.140059.

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Objective.To determine whether macrophage targeting by (R)-11C-PK11195 positron emission tomography (PET) can visualize subclinical joint inflammation in patients with rheumatoid arthritis (RA) without clinical arthritis during or after treatment, with flare as clinical outcome measure.Methods.(R)-11C-PK11195 PET and contrast-enhanced magnetic resonance imaging (MRI) of hands/wrists were performed in 29 patients with RA without clinical arthritis. (R)-11C-PK11195 PET uptake (semiquantitative score 0–3) in metacarpophalangeal, proximal interphalangeal, and wrist joints (i.e., 22 joints per pati
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Rapic, Sara, Heiko Backes, Thomas Viel, et al. "Imaging microglial activation and glucose consumption in a mouse model of Alzheimer's disease." Neurobiology of Aging 34, no. 11 (2012): 351–4. https://doi.org/10.1016/j.neurobiolaging.2012.04.016.

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In Alzheimer’s disease (AD), persistent microglial activation as sign of chronic neuroinflammation contributes to disease progression. Our study aimed to in vivo visualize and quantify microglial activation in 13- to 15-month-old AD mice using [11C]-(R)-PK11195 and positron emission tomography (PET). We attempted to modulate neuroinflammation by subjecting the animals to an anti-inflammatory treatment with pioglitazone (5-weeks’ treatment, 5-week wash-out period). [11C]-(R)-PK11195 distribution volume values in AD mice were significantly higher compared with con
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Dissertations / Theses on the topic "(R)-[11C]PK11195"

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Narciso, Lucas Diovani Lopes. "Avalia??o de m?todos de quantifica??o de imagens PET com [11C]-(R)-PK11195 na investiga??o da esclerose m?ltipla." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2016. http://tede2.pucrs.br/tede2/handle/tede/7072.

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Submitted by Setor de Tratamento da Informa??o - BC/PUCRS (tede2@pucrs.br) on 2016-12-01T15:49:46Z No. of bitstreams: 1 DIS_LUCAS_DIOVANI_LOPES_NARCISO_COMPLETO.pdf: 3232892 bytes, checksum: bde72a06ddadae90febae5d048b0471c (MD5)<br>Made available in DSpace on 2016-12-01T15:49:46Z (GMT). No. of bitstreams: 1 DIS_LUCAS_DIOVANI_LOPES_NARCISO_COMPLETO.pdf: 3232892 bytes, checksum: bde72a06ddadae90febae5d048b0471c (MD5) Previous issue date: 2016-08-31<br>The activation of microglia is an important response to inflammatory processes in the central nervous system (CNS). There has been an increase
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Pais, Marta Silva Lapo. "Machine Learning Classification in Alzheimer’s disease based on 11C-Pittsburgh Compound B (PiB) and 11C-(R)-PK11195 (PK) PET imaging measures and the correlation between these two biomarkers." Master's thesis, 2019. http://hdl.handle.net/10316/87968.

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Trabalho de Projeto do Mestrado Integrado em Engenharia Biomédica apresentado à Faculdade de Ciências e Tecnologia<br>A doença de Alzheimer (AD) é a doença neurodegenerativa responsável pelo maior número de casos de demência. Tomografia por emissão de positrões (PET) com 11C-Pittsburgh Compound B (PiB) e 11C-(R)-PK11195 (PK) são duas modalidades utilizadas na visualização das placas amilóides e da microglia ativada no cérebro humano, respetivamente. Uma vez que as placas amilóides são o principal identificador da AD e que a microglia ativada é também recorrentemente encontrada no cérebro dos
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Book chapters on the topic "(R)-[11C]PK11195"

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Alves, Vítor H., Antero J. Abrunhosa, and Miguel Castelo-Branco. "Synthesis of (R)-[N-Methyl-11C]PK11195." In Radiochemical Syntheses. John Wiley & Sons, Inc, 2015. http://dx.doi.org/10.1002/9781118834114.ch10.

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Cagnin, A., A. Gerhard, and R. B. Banati. "The Concept of In Vivo Imaging of Neuroinflammation with [11C](R)-PK11195 PET." In Neuroinflammation — From Bench to Bedside. Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/978-3-662-05073-6_10.

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Salvi de Souza, Giordana, and Ana Maria Marques da Silva. "Investigation of Time-Activity Curve Behavior in Dynamic [11C]-(R)-PK11195 PET in Cortical Brain Regions: Preliminary Results." In IFMBE Proceedings. Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-9023-3_127.

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Conference papers on the topic "(R)-[11C]PK11195"

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Alves, Vitor H., Antero J. Abrunhosa, and Miguel Castelo-Branco. "Optimisation of synthesis, purification and reformulation of (R)-[N-Methyl-11C]PK11195 for in vivo PET imaging studies." In 2013 IEEE 3rd Portuguese Meeting in Bioengineering (ENBENG). IEEE, 2013. http://dx.doi.org/10.1109/enbeng.2013.6518428.

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