Relevant bibliographies by topics / (R)-2-hydroxy-4-phenylbutyrate

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Academic literature on the topic '(R)-2-hydroxy-4-phenylbutyrate'

Author: Grafiati
Published: 7 June 2025
Last updated: 2 August 2025

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Journal articles on the topic "(R)-2-hydroxy-4-phenylbutyrate"

1

Ou, Zhi Min, and Ren Wei Li. "Kinetic Resolution of Ethyl-2-hydroxy-4-phenylbutyrate with Lipase AK as Catalyst." Advanced Materials Research 560-561 (August 2012): 333–37. http://dx.doi.org/10.4028/www.scientific.net/amr.560-561.333.

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Ethyl (R)-2-hydroxy-4-phenylbutyrate was prepared by enzyme resolution of racemic ethyl- 2-hydroxy-4-phenylbutyrate. The optimal resolution conditions were 0.074 mol/L ethyl-2-hydroxy-4-phenylbutyrate, 20 mg lipase AK in 2.0 ml ethenylethanoate, 30 0C, 100 rpm. Enantiomeric excess of ethyl (R)-2-hydroxy-4-phenylbutyrate was up to 99%. Kinetic resolution model of ethyl- 2-hydroxy-4-phenylbutyrate by lipase AK was described by double substrate ping-pong mechanism. Model data agreed well with experimental data.
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D’Arrigo, Paola, Giuseppe Pedrocchi-Fantoni, and Stefano Servi. "Chemo-enzymatic synthesis of ethyl (R)-2-hydroxy-4-phenylbutyrate." Tetrahedron: Asymmetry 21, no. 8 (2010): 914–18. http://dx.doi.org/10.1016/j.tetasy.2010.05.023.

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Salman, Khan, Li Jiarui, Qin Lei, et al. "Enantioselective reduction of ethyl 2-oxo-4-phenylbutyrate to ethyl (R)-2-hydroxy-4-phenylbutyrate using stereospecific carbonyl reductase KmCR: optimization of cultivation and reaction conditions." Pharmaceutical and Chemical Journal 10, no. 3 (2023): 73–85. https://doi.org/10.5281/zenodo.13990749.

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Ethyl (R)-2-hydroxy-4-phenylbutyrate ((R)-HPBE) is used as an intermediate in the production of angiotensin converting enzyme (ACE) inhibitors for treating various medical conditions. The study used Stereospecific carbonyl reductase (KmCR) enzyme for the asymmetric synthesis of (R)-HPBE. The optimization process involved varying IPTG concentration, induction temperatures, and induction times to determine the optimal culture conditions for producing (R)-HPBE with increased yields. The most efficient culture conditions were determined as 0.2 mM IPTG concentration, 17 °C temperature, and 10 h
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Yang, Yuexi, Yugang Shi, Lifang Feng, and Shiyi Tian. "Coupling of Bioreaction and Separation via Novel Thermosensitive Ionic Liquids Applied in the Baker’s Yeast-Catalyzed Reduction of Ethyl 2-oxo-4-phenylbutyrate." Molecules 25, no. 9 (2020): 2056. http://dx.doi.org/10.3390/molecules25092056.

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The use of baker’s yeast to reduce ethyl 2-oxo-4-phenylbutyrate (EOPB) in conventional biphasic systems is hindered by low productivities due to mass transfer resistance between the biocatalyst and the substrate partitioned into two different phases. To overcome the limitation, a new reaction-separation coupling process (RSCP) was configured in this study, based on the novel thermosensitive ionic liquids (ILs) with polyoxyethylene-tail. The solubility of ILs in common solvents was investigated to configure the unique thermosensitive ionic liquids–solvent biphasic system (TIBS) in which the red
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Herold, P., A. F. Indolese, M. Studer, H. P. Jalett, U. Siegrist, and H. U. Blaser. "New Technical Synthesis of Ethyl (R)-2-Hydroxy-4-phenylbutyrate of High Enantiomeric Purity." Tetrahedron 56, no. 35 (2000): 6497–99. http://dx.doi.org/10.1016/s0040-4020(00)00617-7.

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SU, Yuning, Ye NI, Junchao WANG, Zhihao XU, and Zhihao SUN. "Two-Enzyme Coexpressed Recombinant Strain for Asymmetric Synthesis of Ethyl (R)-2-Hydroxy-4-phenylbutyrate." Chinese Journal of Catalysis 33, no. 9-10 (2012): 1650–60. http://dx.doi.org/10.1016/s1872-2067(11)60436-1.

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Tang, Wen, Lulu Chen, Jian Deng, et al. "Structure-guided evolution of carbonyl reductase for efficient biosynthesis of ethyl (R)-2-hydroxy-4-phenylbutyrate." Catalysis Science & Technology 10, no. 22 (2020): 7512–22. http://dx.doi.org/10.1039/d0cy01411g.

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Qian, Xiao-Long, Jiang Pan, Nai-Dong Shen, Xin Ju, Jie Zhang, and Jian-He Xu. "Efficient production of ethyl (R)-2-hydroxy-4-phenylbutyrate using a cost-effective reductase expressed in Pichia pastoris." Biochemical Engineering Journal 91 (October 2014): 72–77. http://dx.doi.org/10.1016/j.bej.2014.07.008.

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Flynn, Gary A., and Douglas W. Beight. "“An efficient synthesis of ethyl (R)-2-hydroxy-4-phenylbutyrate: A useful intermediate in the synthesis of converting enzymeinhibitors”." Tetrahedron Letters 29, no. 4 (1988): 423–26. http://dx.doi.org/10.1016/s0040-4039(00)80112-4.

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Shi, Yu-Gang, Yun Fang, Hong-Ping Wu, Feng Li, and Xue-Qin Zuo. "Improved production of ethyl-(R)-2-hydroxy-4-phenylbutyrate with pretreatedSaccharomyces cerevisiaein water/organic solvent two-liquid phase systems." Biocatalysis and Biotransformation 27, no. 3 (2009): 211–18. http://dx.doi.org/10.1080/10242420902808333.

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Conference papers on the topic "(R)-2-hydroxy-4-phenylbutyrate"

1

Zhimin, Ou, and Yang Gensheng. "Asymmetric Synthesis of Ethyl (R)-2-hydroxy-4-phenylbutyrate with Catalytic Antibody NB5 as Catalyst." In 2012 International Conference on Biomedical Engineering and Biotechnology (iCBEB). IEEE, 2012. http://dx.doi.org/10.1109/icbeb.2012.85.

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