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Journal articles on the topic 'R.E. Lee Institute'

Author: Grafiati

Published: 4 June 2021

Last updated: 29 July 2025

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1

Li, Yongwei, Vadim Grinenko, and Shushu Li. "Academic system in China: structure, trends and new emerging institutes with Tsung-Dao Lee Institute (TDLI) as a representative example." Superconductivity: Fundamental and Applied Research 6, no. 1 (2025): 13–22. https://doi.org/10.62539/2949-5644-2025-6-1-13-22.

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Our everyday life is unthinkable without various electronic gadgets, household equipment and modern city infrastructure. All of these are the result of past scientific and engineering ideas and developments. The technical level of a country also directly defines how competitive, independent, and stable its economy is. Therefore, China invests significant resources in research and development (R&D). A strong academic system capable of preparing talents for modern industry and leading new research directions is essential for the success of an R&D strategy. This article introduces Chinau2

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Flinn, Ian W., Ulrich Jaeger, Nirav N. Shah, et al. "A First-in-Human Study of YTB323, a Novel, Autologous CD19-Directed CAR-T Cell Therapy Manufactured Using the Novel T-Charge TM platform, for the Treatment of Patients (Pts) with Relapsed/Refractory (r/r) Diffuse Large B-Cell Lymphoma (DLBCL)." Blood 138, Supplement 1 (2021): 740. http://dx.doi.org/10.1182/blood-2021-146268.

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Abstract Background: Despite unprecedented efficacy of existing CAR-T cell therapy, many pts fail to respond to the therapy, or relapse after initial response. YTB323 is an autologous CD19-directed CAR-T cell therapy utilizing the FMC63 domain for CD19 recognition and 4-1BB costimulatory domain. YTB323 is manufactured with an innovative simplified process, called T-Charge TM, which reduces the ex vivo culture time to about 24 hours and takes &lt;2 d to manufacture the final product. The T-Charge TM platform preserves naive and stem cell memory T (T scm) cells in the final product (preclini

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Milovanovic, Milan, and Vesna Bikic. "Vladimir R. Petkovic and the foundation of the institute of archaeology: Circumstances and realization." Starinar, no. 74 (2024): 313–39. https://doi.org/10.2298/sta2474313m.

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In the process of establishing the Institute of Archaeology, the role of Vladimir Petkovic turned out to be crucial. Starting in the Kingdom of Yugoslavia and ending in the post-war Federal People?s Republic of Yugoslavia, the process had a constant which was contained in the idea and intention to organize and coordinate archaeological research in Serbia under the umbrella of a scientific institution. The initiation of the process, regarding that, lasted a little more than ten years and had several stages. The beginning was marked by a change at the head of the main museum institution - the Hi

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Kurygin, Al A., V. A. Neverov, and V. V. Semenov. "Professor Roman Romanovich Vreden (1867–1934) (on the 155<sup>th</sup> anniversary of his birth)." Grekov's Bulletin of Surgery 181, no. 6 (2022): 7–11. http://dx.doi.org/10.24884/0042-4625-2022-181-6-7-11.

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An outstanding orthopedic traumatologist and military field surgeon, scientist and teacher, one of the founders of orthopedics in Russia, founder and long-term director of the St. Petersburg Orthopedic Institute (1906–1924), organizer of the first Department of Pediatric Surgery in Russia (1933) and creator of a large scientific school of orthopedic traumatologists, Professor Roman Romanovich Vreden was born on March 9 (21), 1867 in St. Petersburg in the family of a well-known otorhinolaryngologist, Professor Robert Robertovich Vreden. From childhood, Roman chose the profession of a doctor for

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Khashila, Marwan, Mahmoud N. Hussien, Mourad Karray, and Mohamed Chekired. "Use of pore pressure build-up as damage metric in computation of equivalent number of uniform strain cycles." Canadian Geotechnical Journal 55, no. 4 (2018): 538–50. http://dx.doi.org/10.1139/cgj-2017-0231.

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The build-up of earthquake-induced excess pore-water pressure may be viewed as analogous to the cumulative damage of saturated granular materials caused by cyclic loading, and consequently as a damage metric when converting an irregular earthquake loading to an equivalent number of uniform cycles, Neq. In this paper, a comprehensive series of strain-controlled tests have been conducted using the new combined triaxial simple shear (TxSS) apparatus developed at Institute de Recherche d’Hydro-Quebec (IREQ) in collaboration with the geotechnical group at the Université de Sherbrooke to verify the

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Sharafatdinova, R., та X.Q. Matjanova. "QORAQALPOQISTONDA TIKANLI KOVUL (CAPPARIS SPINOSA) OʻSIMLIGINI YETISHTIRISH VA ULARNING AHAMIYATI". Role of agriculture and medicine in science va O'zbekiston Agrar fani xabarnomasi Maxsus son, № 1/1(19) 2025 (2025): 113–18. https://doi.org/10.5281/zenodo.15016192.

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<strong>QORAQALPOQISTONDA</strong><strong> </strong><strong>TIKANLI</strong><strong> </strong><strong>KOVUL</strong><strong> (</strong><strong><em>CAPPARIS</em></strong><strong><em> </em></strong><strong><em>SPINOSA</em></strong><strong>) </strong><strong>O</strong><strong>ʻ</strong><strong>SIMLIGINI</strong><strong> </strong><strong>YETISHTIRISH</strong><strong> </strong><strong>VA</strong><strong> </strong><strong>ULARNING</strong><strong> </strong><strong>AHAMIYATI</strong> 1.<strong>Sharafatdinova R.</strong>2 <strong>Matjanova X.Q.</strong> Qoraqalpog‘iston qishloq xo‘jaligi v

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Silvestre, Jason, Qing Z. Ruan, and Benjamin Chang. "Analysis of National Institutes of Health Funding in Hand Surgery." HAND 14, no. 4 (2018): 560–64. http://dx.doi.org/10.1177/1558944717751719.

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Background: Federal research dollars help investigators develop biomedical therapies for human diseases. Currently, the state of funding in hand surgery is poorly understood. This study defines the portfolio of National Institutes of Health (NIH) grants awarded in hand surgery. Methods: This was a cross-sectional study of hand surgeons in the US. Faculty members of accredited hand surgery fellowships and/or members of the American Society for Surgery of the Hand were queried in the NIH RePORT database for awards obtained during 2005-2015. Results: Of 2317 hand surgeons queried, only 18 obtaine

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Fári, Miklós Gábor. "The development of the scientific bases of horticulture and the history of horticultural innovation in the Northern Great Plain region and in Debrecen." Acta Agraria Debreceniensis, no. 17 (September 14, 2005): 17–20. http://dx.doi.org/10.34101/actaagrar/17/3264.

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It can be told about the second half of the XXth century that, apart from preferring the large-scale growing of field plants and the largescalelivestock farming, corresponding to the central political will of the communist era, the significance and innovation output ofhorticultural education in Debrecen was rather of follow-up trait, of secondary importance. The Tobacco Research Institute continued theresearch work, and then even this activity was stopped. According to a survey finished in 1997, the mentioned institute had no invention,granted patent, protection for registered model or any app

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Marina, Lage da Gama Lima. "La participación del Instituto de Arquitetos do Brasil en las políticas habitacionales brasileras de los años 1960 = The participation of the Brazilian Architects Institute in Brazilian housing policies in the 1960s." rita_ Revista Indexada de Textos Académicos, no. 12 (November 5, 2019): 112–17. https://doi.org/10.24192/2386-7027(2019)(v12)(06).

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El artículo presenta cómo el Instituto de Arquitectos de Brasil (IAB) participó en los procesos de elaboración de políticas públicas de vivienda en Brasil en la década de 1960 utilizando como fuente principal informes de las revistas especializadas Guanabara (1961-1962) y Arquitetura (1962-1968). También intentamos demonstrar la hipótesis de que la instalación del régimen militar en Brasil llevó a la eliminación de los arquitectos del IAB de los procesos de toma de decisiones de las políticas de v

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Mukhangaliyeva, Zhanar, Akkaiyn Balykova, and Zhanna Mazhitova. "Ukrainian scientists at the Tselinograd State Medical Institute: Contribution to education and science (1960s)." History of science and technology 14, no. 2 (2024): 350–73. https://doi.org/10.32703/2415-7422-2024-14-2-350-373.

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The article examines the work, scientific achievements, and contribution of Doctor of Medical Sciences, Professor Viktor Rafailovich Faitelberg-Blank and Candidate of Medical Sciences, Associate Professor Maria Vasilievna Kropelnitskaya to the development of the Tselinograd State Medical Institute in the 1960s. Authors used the methods of microhistory and comparative historical analysis to achieve the goal of the study, which made it possible to comprehensively reveal the activities of scientists and organizers of medical education V. R. Faitelberg-Blank and M. V. Kropelnitskaya in the Virgin

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Whelan, Kevin, T. Jones Hughes, P. J. Duffy, et al. "Reviews of Books." Irish Geography 18, no. 1 (2016): 76–88. http://dx.doi.org/10.55650/igj.1985.732.

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IRISH GEOGRAPHY: THE GEOGRAPHICAL SOCIETY OF IRELAND GOLDEN JUBILEE 1934-1984, edited by G. L. Herries Davies. Dublin: The Geographical Society of Ireland, 1984. 294pp. IR£12.00. No ISBN. Reviewed by KEVIN WHELANIRELAND: TOWARDS A SENSE OF PLACE, edited by Joseph Lee. Cork: Cork University Press, 1985. 107pp. IR£4.00. ISBN 0 902561 35 9. Reviewed by T. JONES HUGHESTHE PLANTATION OF ULSTER, by Philip Robinson. Dublin: Gill & MacMillan, 1984,254pp. IR£25.00. ISBN 7171 1106 7. Reviewed by P. J. DUFFYRURAL HOUSES OF THE NORTH OF IRELAND, by Alan Gailey, Edinburgh: John Donald, 1984. 289pp. IR£

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Miller, Jeffrey, Frank Cichocki, Jianfang Ning, et al. "155 iPSC-derived NK cells mediate robust anti-tumor activity against glioblastoma." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (2020): A169. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0155.

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BackgroundGliomas represent the most common brain tumors within the central nervous system, with glioblastoma being the most aggressive type.1 Conventional treatment combines several approaches including surgery, chemotherapy, and radiation.2 However, the prognosis for glioblastoma remains unfavorable, with only 5% of patients surviving more than 5 years post-diagnosis.3 Thus, new treatment approaches are urgently needed. Natural killer (NK) cells directly lyse malignantly transformed or virally infected cells and secrete inflammatory cytokines that polarize cytotoxic immunity. Allogeneic NK c

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Ali, Liaqat, Muhammad Shah, Mohammad Shahzad, Faiza Hayat, Mohammad Hanif, and Nasir Orakzai. "Simulation in Urological Training: The Hybrid Model of Institute of Kidney Diseases Peshawar A Comparative Study." Pakistan Journal of Medical and Health Sciences 16, no. 12 (2022): 320–22. http://dx.doi.org/10.53350/pjmhs20221612320.

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Background:"I fear the man who has practised one kick 10,000 times." Lee Bruce This aphorism highlights the growing importance of simulation in postgraduate urology training, especially during the COVID 19 pandemic, when all teaching and training activities were stopped, jeopardising postgraduate residents' education. Postgraduate residents must perform hours of surgical training to overcome urological learning curves. According to study, residents educated on simulators boost their summative scores. By introducing simulation to urology training in a way comparable to the well-known Halsted ap

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Ma, Dali. "Boundary repair: Science and enterprise at the Chinese Academy of Sciences." Social Studies of Science 49, no. 3 (2019): 381–402. http://dx.doi.org/10.1177/0306312719846560.

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In the 1980s, the Chinese state pushed the Chinese Academy of Sciences (CAS) to establish businesses. Some of these businesses did not engage in any research and development (R&D), and this resulted in scientists having concerns about the boundary around the institutionalizing scientific community. When the state supported CAS’s ‘Knowledge Innovation’ reform in the late 1990s, CAS’s organizing principle became centered on a more narrowly scientific logic, which led to less reliance on business income. Regression analysis indicates that CAS-owned enterprises without R&D were more likely

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Kaliszuk, Jerzy. "Działalność Pracowni Wiedzy o Dawnej Książce Instytutu Historii Nauki PAN w 2022 r." Kwartalnik Historii Nauki i Techniki 68, no. 3 (2023): 227–36. http://dx.doi.org/10.4467/0023589xkhnt.23.036.18416.

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Research Activity of the Old and Rare Book Studies Research Unit at the Institute for the History of Science PAS in 2022 The article presents the achievements of the Old and Rare Book Studies Research Unit in 2022 in the scope of documentation, scientific, and popularization activities. The research conducted by the Unit members primarily focused on the Manuscripta.pl project, which led to new and significant discoveries concerning medieval manuscripts, the history of book collections and individual codices. In addition to the work related to the implementation of the NPRH project, team member

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Jemioł, Maciej. "Report from the debate: How to think with Heidegger against Heidegger?" Forum Philosophicum 28, no. 1 (2023): 207–9. http://dx.doi.org/10.35765/forphil.2023.2801.11.

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From the initiative of the Institute of Philosophy of the Jesuit University Ignatianum in Krakow there was a debate last May that centred on a book by young author Filip Borek from the Institute of Philosophy and Sociology of the Polish Academy of Sciences, who is also a member of the board of the Polish Phenomenological Association. His book consists of a phenomenological interpretation of Vom Wesen der Wahrheit [On the Essence of Truth], an important work in which Heidegger explores the essential connection between truth as correctness and freedom. In attendance were the following guests: Ma

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Kwon, Peter Banseok. "Defender of the Nation, Champion of Science: The Agency for Defense Development as a Nexus for the Technological Transformation of South Korea." Journal of Korean Studies 28, no. 1 (2023): 59–90. http://dx.doi.org/10.1215/07311613-10213182.

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Abstract The Agency for Defense Development (ADD) has functioned as South Korea’s central institute for weapons research and development (R&D) since 1970, when it was established by the Park Chung Hee regime (1961–79). As argued in this article, this quasi-private, quasi-public military institute also fostered major advancements of science and technology during the transformative decade of South Korea’s “militarized industrialization,” the 1970s, with a lasting impact on the private sector and business relations with the state. Drawing from in-person interviews with living scientists who w

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Conanec, Alexandre, Brigitte Picard, Denis Durand, et al. "New Approach Studying Interactions Regarding Trade-Off between Beef Performances and Meat Qualities." Foods 8, no. 6 (2019): 197. http://dx.doi.org/10.3390/foods8060197.

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The beef cattle industry is facing multiple problems, from the unequal distribution of added value to the poor matching of its product with fast-changing demand. Therefore, the aim of this study was to examine the interactions between the main variables, evaluating the nutritional and organoleptic properties of meat and cattle performances, including carcass properties, to assess a new method of managing the trade-off between these four performance goals. For this purpose, each variable evaluating the parameters of interest has been statistically modeled and based on data collected on 30 Blond

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Koshlyakov, M. N., A. G. Zatsepin, and S. A. Sviridov. "DOUBLE ANNIVERSARY OF PROFESSOR VLADIMIR STOKMAN." Journal of Oceanological Research 47, no. 5 (2019): 177–84. http://dx.doi.org/10.29006/1564-2291.jor-2019.47(5).13.

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In 2019, the 110th anniversary of the birth of the outstanding Soviet oceanologist – Professor Vladimir Shtokman, with whose name is closely connected to the formation and development of dynamic oceanology in our country, is celebrated. In the same year, another significant date is celebrated – 40 years from the date of the introduction of the R/V Professor Shtokman into the scientific fleet of the USSR Academy of Sciences. The research vessel is named after the outstanding scientist V.B. Shtokman, who led the theoretical research at the Shirshov Institute of Oceanology from 1946 to 1968.

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Duran, Kevin. "Reviewer Acknowledgements for International Business Research, Vol. 11, No. 10." International Business Research 11, no. 10 (2018): 174. http://dx.doi.org/10.5539/ibr.v11n10p174.

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International Business Research wishes to acknowledge the following individuals for their assistance with peer review of manuscripts for this issue. Their help and contributions in maintaining the quality of the journal are greatly appreciated.  International Business Research is recruiting reviewers for the journal. If you are interested in becoming a reviewer, we welcome you to join us. Please find the application form and details at http://www.ccsenet.org/journal/index.php/ibr/editor/recruitment and e-mail the completed application form to ibr@ccsenet.org.   Reviewer

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KITLV, Redactie. "Book Reviews." Bijdragen tot de taal-, land- en volkenkunde / Journal of the Humanities and Social Sciences of Southeast Asia 158, no. 2 (2002): 305–63. http://dx.doi.org/10.1163/22134379-90003783.

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-Greg Bankoff, Alfred W. McCoy, Lives at the margin; Biography of Filipinos obscure, ordinary and heroic. Madison, Wisconsin: Center for Southeast Asian Studies, University of Wisconsin-Madion, v + 481 pp. -Greg Bankoff, Clive J. Christie, Ideology and revolution in Southeast Asia 1900-1980; Political ideas of the anti-colonial era. Richmond, Surrey: Curzon Press, xi + 236 pp. -René van den Berg, Videa P. de Guzman ,Grammatical analysis; Morphology, syntax, and semantics; Studies in honor of Stanley Starosta. Honolulu: University of Hawai'i Press, xv + 298 pp. [Oceanic Linguistics Special Publ

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Lucas Prado, Clementina Corah. "A adoção do limite custo-efetividade na incorporação de tecnologias no SUS – o que se pode esperar." Revista Eletronica Gestão & Saúde 6, no. 4 (2015): 3127. http://dx.doi.org/10.18673/gs.v6i4.22103.

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Objetivo: Revisar o uso de avaliação custo-efetividade na incorporação de tecnologias em sistemas de saúde e informações sobre o limite custo-efetividade, especialmente embasadas na experiência do The National Institute for Health and Care Excellence – NICE no Reino Unido, a fim de pontuar os desafios que se apresentam ao caso brasileiro. Metodologia: Levantamento bibliográfico sobre o uso de avaliações econômicas na tomada de decisão em saúde e do Limite Custo-Efetividade (LCE) e suas consequências. Resultados: Há uma tendência atual de se adotar de forma explicita o LCE, sendo incipientes os

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Bishop, Michael R., Michael Dickinson, Duncan Purtill, et al. "Tisagenlecleucel Vs Standard of Care As Second-Line Therapy of Primary Refractory or Relapsed Aggressive B-Cell Non-Hodgkin Lymphoma: Analysis of the Phase III Belinda Study." Blood 138, Supplement 2 (2021): LBA—6—LBA—6. http://dx.doi.org/10.1182/blood-2021-155068.

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Abstract Background: Standard of care (SOC) for second-line (2L) therapy (tx) of relapsed/refractory aggressive B-cell non-Hodgkin lymphomas (R/R aNHL) includes platinum-based chemotherapy (PCT) followed by autologous hematopoietic cell transplantation (aHCT) in responders. Outcomes are poor for patients (pts) with R/R aNHL who experience progression during or within 12 months (mo) of 1L tx. Tisagenlecleucel (tisa-cel) is an autologous chimeric antigen receptor (CAR) T-cell tx targeting CD19 approved for pts with large B-cell lymphoma (LBCL; US) and diffuse LBCL (non-US) after ≥2 lines of tx.

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White, Brian S., Suleiman A. Khan, Muhammad Ammad-ud-din, et al. "Comparative Analysis of Independent Ex Vivo functional Drug Screens Identifies Predictive Biomarkers of BCL-2 Inhibitor Response in AML." Blood 132, Supplement 1 (2018): 2763. http://dx.doi.org/10.1182/blood-2018-99-111916.

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Abstract Introduction: Therapeutic options for patients with AML were recently expanded with FDA approval of four drugs in 2017. As their efficacy is limited in some patient subpopulations and relapse ultimately ensues, there remains an urgent need for additional treatment options tailored to well-defined patient subpopulations to achieve durable responses. Two comprehensive profiling efforts were launched to address this need-the multi-center Beat AML initiative, led by the Oregon Health & Science University (OHSU) and the AML Individualized Systems Medicine program at the Institute for M

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Woyach, Jennifer A., Ian W. Flinn, Farrukh T. Awan, et al. "Preliminary Efficacy and Safety of MK-1026, a Non-Covalent Inhibitor of Wild-Type and C481S Mutated Bruton Tyrosine Kinase, in B-Cell Malignancies: A Phase 2 Dose Expansion Study." Blood 138, Supplement 1 (2021): 392. http://dx.doi.org/10.1182/blood-2021-148672.

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Abstract Introduction: Bruton tyrosine kinase inhibitors (BTKi) have revolutionized the treatment of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and certain B-cell neoplasms. However, resistance to BTKi develops primarily through mutations at the cysteine binding site (C481) or PLCγ2 mutations. MK-1026 (formerly ARQ-531) is a non-covalent, potent inhibitor of both wild type and C481- mutated BTK. In the phase 1/2 dose escalation and dose expansion study NCT03162536, the preliminary recommended phase 2 dose (RP2D) of MK-1026 was determined to be 65 mg once daily. The effic

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KUMAR, SUNIL, and RAMANJIT KAUR. "Controlling Phalaris minor with novel pyroxasulfone under conservation agriculture in the north-western Indo-Gangetic Plains." Indian Journal of Agricultural Sciences 94, no. 1 (2024): 074–79. http://dx.doi.org/10.56093/ijas.v94i1.143436.

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A field experiment was conducted during the winter (rabi) seasons of 2021–22 and 2022–23 at the research farm of ICAR-Indian Agricultural Research Institute, New Delhi to evaluate the effectiveness of pyroxasulfone in controlling resistant Phalaris minor within the maize (Zea mays L.)-wheat (Triticum aestivum L.) cropping system. The experiment consisted a split-plot design involving 3 crop establishment systems (Bed + R; ZT + R and CT + R) and 5 weed management strategies, viz. pyroxasulfone (W1); pyroxsulfone fb metsulfuron + carfentrazone (W2); Sulfosulfuron + metsulfuron (W3); UWC (W4); an

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MOISUC, Diana Aderina, and Sorin Adrian ACHIM. "THE IMPACT OF INVESTMENTS IN CLOUD COMPUTING AND WEBSITES UPON RESEARCH AND DEVELOPMENT COSTS IN THE PRIVATE SECTOR." Review of Management and Economic Engineering 24, no. 1 (2025): 50–57. https://doi.org/10.71235/rmee.197.

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The accelerated digitalization of the private sector has led to a significant increase in investments in technologies such as cloud computing and websites, which are essential factors in business modernization and innovation support. This study analyzes the impact of investments in these technologies on research and development (R&D) expenses, using official data provided by the National Institute of Statistics (INSSE). Investments in cloud computing offer advantages such as reduced operational costs, easy access to advanced IT infrastructures, and optimization of research and development

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Kim, Ju Won, Hee Kyung Ahn, Jong Gwon Choi, et al. "Abstract P5-16-03: Phase II study of trastuzumab biosimilar (Herzuma®) plus gedatolisib in patients with HER-2 positive metastatic breast cancer who progressed after 2 or more HER-2 directed chemotherapy (BR 18-13, KM-10A): Interim analysis." Cancer Research 82, no. 4_Supplement (2022): P5–16–03—P5–16–03. http://dx.doi.org/10.1158/1538-7445.sabcs21-p5-16-03.

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Abstract Background: Prognosis of patients with HER-2 positive metastatic breast cancer (MBC) has been revolutionized with the development of monoclonal antibodies targeting HER-2 and antibody-drug conjugate, but resistance to anti-HER-2 therapy is inevitable ultimately. PI3K-AKT-mTOR pathway aberration is known to be one of the key resistance mechanisms. BR18-13(KM-10A) study is a phase 2 clinical trial evaluating efficacy and safety of Herzuma® (trastuzumab biosimilar) plus Gedatolisib (dual PI3K/mTORC inhibitor) in patients with HER-2 positive MBC who progressed after multiple lines of ther

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Advani, Ranjana H., Michael J. Dickinson, Christopher P. Fox, et al. "SKYGLO: A Global Phase III Randomized Study Evaluating Glofitamab Plus Polatuzumab Vedotin + Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone (Pola-R-CHP) Versus Pola-R-CHP in Previously Untreated Patients with Large B-Cell Lymphoma (LBCL)." Blood 144, Supplement 1 (2024): 1718.1. https://doi.org/10.1182/blood-2024-194000.

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Background and Significance: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of aggressive non-Hodgkin lymphoma. R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) is a standard first line (1L) therapy for DLBCL but only ~60% of patients (pts) achieve durable remissions. Recently, Pola-R-CHP became the first therapy to be approved by the FDA for 1L treatment of DLBCL in ~20 years, and demonstrated a significant progression-free survival (PFS) benefit (hazard ratio: 0.73; 95% confidence interval 0.57-0.95; p=0.02) over R-CHOP (Tilly, et al. NEJM 2022

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Pretorius, Z. A., W. H. P. Boshoff, and G. H. J. Kema. "First Report of Puccinia striiformis f. sp. tritici on Wheat in South Africa." Plant Disease 81, no. 4 (1997): 424. http://dx.doi.org/10.1094/pdis.1997.81.4.424d.

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During August 1996, stripe (yellow) rust, caused by Puccinia striiformis f. sp. tritici, was observed for the first time on bread wheat (Triticum aestivum) in the Western Cape, South Africa. Ensuing surveys during the growing season indicated that stripe rust occurred throughout most of the wheat-producing areas in the winter rainfall regions of the Northern, Western, and Eastern Cape provinces. The disease was also observed on irrigated wheat in the summer rainfall area south of Kimberley. Stripe rust was most severe in the Western Cape, where prolonged cool and wet conditions favored epidemi

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Choi, Byungsan, Yunseo Lee, Lilly Gu, et al. "Abstract 2056: Development of a response prediction Model for venetoclax-based therapy utilizing molecular interactions among BCL2 family members." Cancer Research 85, no. 8_Supplement_1 (2025): 2056. https://doi.org/10.1158/1538-7445.am2025-2056.

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Abstract Venetoclax (VEN), in combination with hypomethylating agents (HMAs) such as azacitidine or decitabine, is a widely used treatment for AML patients, yet the molecular biomarkers contributing to sensitivity to the VEN+HMA regimen remain incompletely elucidated, particularly with regard to the role of BCL2-family proteins. In this study, we retrospectively collected BMMCs or PBMCs from AML patients prior to initiation of VEN+HMA therapy at Winship Cancer Institute of Emory University. A total of 47 specimens were analyzed, including 33 from newly diagnosed AML patients and 14 from relaps

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Roberts, Andrew W., Shuo Ma, Danielle M. Brander, et al. "Determination of Recommended Phase 2 Dose of ABT-199 (GDC-0199) Combined with Rituximab (R) in Patients with Relapsed / Refractory (R/R) Chronic Lymphocytic Leukemia (CLL)." Blood 124, no. 21 (2014): 325. http://dx.doi.org/10.1182/blood.v124.21.325.325.

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Abstract Introduction: ABT-199 is a selective, orally bioavailable BCL-2 inhibitor that rapidly induces responses in ~80% of patients (pts) with relapsed/refractory (R/R) CLL or small lymphocytic lymphoma (SLL) as a single agent (Seymour, EHA 2014). Rituximab (R) has only modest and short-lived activity as a single-agent in CLL; it can enhance the activity of other agents with minimal additional toxicity. ABT-199 and R demonstrate synergy in preclinical models of CD20-positive lymphoid malignancies, and the combination has the potential to improve efficacy. Methods: Primary objectives of this

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Chavan, Aishwarya M., Geetha R. Acharya, Jyoti V. Kale, and Nidhi R. Dabral. "Transversus abdominis plane block by landmark technique with ropivacaine versus bupivacaine for post-operative analgesia in patients undergoing lower segment caesarean section deliveries." Indian Journal of Clinical Anaesthesia 8, no. 4 (2021): 551–55. http://dx.doi.org/10.18231/j.ijca.2021.118.

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Transversus Abdominis Plane (TAP) Block is an efficacious abdominal field block which is widely used component of multimodal analgesia. Compare the efficacy of Inj. Ropivacaine 0.2% and Inj. Bupivacaine 0.2% when used in TAP block for post-operative analgesia in lower segment caesarean section deliveries(LSCS) done under spinal anaesthesia. Randomized double blinded prospective study conducted after institutional ethics committee in our institute. We have recruited sixty patients scheduled for an elective LSCS which were enrolled into two groups to receive TAP block with bupivacaine 0.2% 15ml

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Chuateco, Clinyl Mae, Dominic Cervantes, Daisy Grace Lipasana, Anjelica Devi Mosqueda, Jaron Requinton, and Olivia Dimatulac. "The Athletic Identity and Level of Optimism of Selected University of Santo Tomas Institute Student-Athletes during the Covid-19 Pandemic." INSPIREE: Indonesian Sport Innovation Review 3, no. 03 (2022): 185–98. http://dx.doi.org/10.53905/inspiree.v3i03.90.

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The purpose of the study. The COVID-19 pandemic has impacted sporting events, which led to the cancellation of games and student-athletes being isolated at home and conducting their training online. The study looked at how student-athletes view themselves and their levels of optimism before and during the pandemic. Materials and methods. The study is a descriptive quantitative research that adapted the constructs of the Athletic Identity Measurement Scale (AIMS) and Revised Life Orientation Test (LOT-R). Slovin’s formula and stratified random sampling were used to select the respondents. Googl

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Tenkouano, Abdou, Niéyidouba Lamien, Josephine Agogbua, et al. "Promising High-Yielding Tetraploid Plantain-Bred Hybrids in West Africa." International Journal of Agronomy 2019 (April 21, 2019): 1–8. http://dx.doi.org/10.1155/2019/3873198.

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The devastating threat of black leaf streak disease caused by Pseudocercospora fijiensis on plantain production in West Africa spurred the development of resistant hybrids. The goal of this research and development (R&D) undertaken was assessing the development and dissemination of two plantain hybrids PITA 3 and FHIA 21 bred in the 1980s by the International Institute of Tropical Agriculture (IITA, Nigeria) and the Fundación Hondureña de Investigación Agrícola (FHIA, Honduras), respectively. In Côte d’Ivoire, plantain growers selected PITA 3 and FHIA 21 based on their improved agronomic c

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Takagi, Hiroshi. "History and Future Prospect of Electro-ceramics in Japan and Asia." Additional Conferences (Device Packaging, HiTEC, HiTEN, and CICMT) 2012, CICMT (2012): 000002–9. http://dx.doi.org/10.4071/cicmt-2012-kn2_murata.

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On the background of a long history of Japanese ceramics, various electro-ceramic materials have been studied and many kinds of electronic components using them have been developed in Japan. The first invention of electro-ceramics in Japan should be a ferrite at Tokyo Institute of Technology in 1930, and the mass production of ferrite started in 1937. Then, Japanese electro-ceramic industry has led the world on electro-ceramic materials and components until now, especially in the fields of BaTiO3, PZT, PTC thermistor, ZnO varistor and insulating ceramics. In recent years, new electro-ceramic m

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Kosovsky, G. Yu, E. V. Krovina, N. I. Tinaev, A. R. Shumilina, and T. K. Karelina. "The main provisions of the national standard GOST R 70141-2022 “Rabbit breeding. Terms and definitions”." Krolikovodstvo i zverovodstvo, no. 2 (2023): 13–17. https://doi.org/10.52178/00234885_2023_2_13.

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New terminology has substantially expanded zootechnical science and practice, particularly rabbit breeding, in recent years. The need to update the out-of-date GOST 22294-76 «Agriculture. Rabbit Breeding. Terms and Definitions,» which does not completely cover all utilized ideas, led to the establishment of GOST State Standard 70141-2022 «Rabbit Breeding. Terms and Definitions.». The Federal State Budgetary Scientific Institution «Scientific Research Institute Fur-Bearing Animal Breeding and Rabbit Breeding named after V.A. Afanas’ev» developed GOST- State Standard 70141-2022, and the Technica

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Munoz-Martin, Joan Francesc, Adrian Perez, Adriano Camps, et al. "Snow and Ice Thickness Retrievals Using GNSS-R: Preliminary Results of the MOSAiC Experiment." Remote Sensing 12, no. 24 (2020): 4038. http://dx.doi.org/10.3390/rs12244038.

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The FSSCat mission was the 2017 ESA Sentinel Small Satellite (S⌃3) Challenge winner and the Copernicus Masters competition overall winner. It was successfully launched on 3 September 2020 onboard the VEGA SSMS PoC (VV16). FSSCat aims to provide coarse and downscaled soil moisture data and over polar regions, sea ice cover, and coarse resolution ice thickness using a combined L-band microwave radiometer and GNSS-Reflectometry payload. As part of the calibration and validation activities of FSSCat, a GNSS-R instrument was deployed as part of the MOSAiC polar expedition. The Multidisciplinary dri

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Lemaistre, Charles A. "R. lee clark." Cancer 74, no. 5 (1994): 1513–15. http://dx.doi.org/10.1002/1097-0142(19940901)74:5<1513::aid-cncr2820740502>3.0.co;2-b.

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Ahsani, S. A. H. "The State of Research on Islamic Spain." American Journal of Islam and Society 9, no. 4 (1992): 556–62. http://dx.doi.org/10.35632/ajis.v9i4.2541.

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The era of Muslim rule in Spain (711-1491 CE) witnessed great contributionsin many areas of knowledge and learning. Rapid strides weremade in such diverse fields as art and architecture, agriculture and handicrafts,linguistics and literature, humanities and Social studies, music andpoetry, and the physical and mechanical sciences. In fact, Islamic Spain,known to the Muslim world as al Andalus, served as a bridge for thetransfer of the knowledge and wisdom of Classical Greece to Europe, aprocess that eventually led to the European Renaissance.The achievements of al Andalus will not be discussed

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Ammad Ud Din, Mohammad, Katherine Tobon, Julio C. Chavez, et al. "The Real-World Safety and Tolerability of Pirtobrutinib Among Patients with B Cell Lymphomas; A Single Center Experience." Blood 144, Supplement 1 (2024): 6778. https://doi.org/10.1182/blood-2024-208769.

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Background: Pirtobrutinib is an oral highly selective noncovalent Bruton tyrosine kinase inhibitor (BTKi) that has shown promising efficacy in heavily treated patients with relapsed/refractory (R/R) B cell lymphomas. We conducted a single-center retrospective study evaluating the safety and tolerability of pirtobrutinib in the real-world setting. Methods: The data for this study was gathered using the prescription records from the outpatient pharmacy at the H Lee Moffitt Cancer Center and Research Institute. All patients who were prescribed pirtobrutinib from June 1st, 2022 to June 1st, 2024 a

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Choi, C. B., T. Y. Lee, K. S. Kim, and S. C. Bae. "AB0370 SAFETY OF CS20AT04, A HAPLOIDENTICAL ALLOGENEIC BONE MARROW-DERIVED MESENCHYMAL STEM CELLS, IN A PHASE 1 STUDY IN LUPUS NEPHRITIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1485.2–1485. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3287.

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Background:Mesenchymal stem cells are known to have immunomodulatory properties and may potentially have therapeutic effect in lupus nephritis. Mesenchymal stem cells form a haploidentical donor are an attractive cell sourceObjectives:CS20AT04, a haploidentical allogeneic bone marrow-derived mesenchymal stem cell, was evaluated in patients with lupus nephritis for safety and tolerability.Methods:This was a single-arm phase 1 dose-escalation trial of CS20AT04 in adult patients with lupus nephritis (NCT03174587). A 3 + 3 design was used for dose escalation. The starting dose was 2.0 x 106 cells/

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Moujalled, Donia M., Fiona C. Brown, Giovanna Pomilio, et al. "Acquired Mutations in BAX Confer Resistance to BH3 Mimetics in Acute Myeloid Leukemia." Blood 136, Supplement 1 (2020): 7–8. http://dx.doi.org/10.1182/blood-2020-136872.

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Background: Recent randomized trials have demonstrated improvements in overall survival (OS) for the BCL-2 inhibitor venetoclax (VEN) in combination with azacitidine and low dose cytarabine in older unfit patients with AML. Pre-clinical studies identified BAX deficiency as a potential mechanism of VEN resistance in AML, but this has not been observed in patients to date (Chen, Cancer Disc 2019). Methods: Patient samples were derived from studies approved by the Alfred Ethics Committee. BAX sequencing was performed using targeted sequencing. In vivo studies used NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ

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Li, Hong, Si-Yu Li, Yang Liu, et al. "Probing primordial gravitational waves: Ali CMB Polarization Telescope." National Science Review 6, no. 1 (2018): 145–54. http://dx.doi.org/10.1093/nsr/nwy019.

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Abstract In this paper, we will give a general introduction to the Ali CMB Polarization Telescope (AliCPT) project, which is a Sino–US joint project led by the Institute of High Energy Physics and involves many different institutes in China. It is the first ground-based Cosmic Microwave Background (CMB) polarization experiment in China and an integral part of China's Gravitational-wave Program. The main scientific goal of the AliCPT project is to probe the primordial gravitational waves (PGWs) originating from the very early Universe. The AliCPT project includes two stages. The first stage, re

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Nelson Wekha, Wafula, Nicholas Kibet Korir, Moses Siambi, Henry F. Ojulong, and Joseph P. Gweyi-Onyango. "Agromorphological Performance and Character Association of Finger Millet under Varying Phosphorus Regimes." Journal of Agricultural Studies 5, no. 1 (2017): 90. http://dx.doi.org/10.5296/jas.v5i1.10809.

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Finger millet production on more than 30% of world arable land is limited by P availability and more than 70% in the semi-arid and marginalized areas which covers most of the Sub-Saharan Africa. Phosphorus is one of the most important elements significantly affecting plant growth and metabolism. Three finger millet varieties (U-15, P-224 and Ikhulule) were evaluated under four P fertilizer levels (0, 12.5, 25 and 37.5 kg ha-1 P2O5) at the International Crops Research Institute for the Semi-Arid Tropics Station, Alupe and the Kenya Agricultural and Livestock Research Organization Station, Kakam

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Carvalho, Roberto L. da S., and Angel R. S. Delgado. "Estimates of reference evapotranspiration in the municipality of Ariquemes (RO) using neural networks GMDH-type." Revista Brasileira de Engenharia Agrícola e Ambiental 23, no. 5 (2019): 324–29. http://dx.doi.org/10.1590/1807-1929/agriambi.v23n5p324-329.

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ABSTRACT Reference evapotranspiration is a climatological variable of great importance for water use dimensioning in irrigation methods. In order to contribute to the climatic understanding of Ariquemes, Rodônia state, Brazil, the study aims to model the behavior of the time series of reference evapotranspiration using a GMDH-type (Group Method of Data Handling) artificial neural network (ANN) and to compare it with the SARIMA (Seasonal Autoregressive Integrated Moving Average) methodology. Data from the National Institute of Meteorology - INMET, obtained at the Automatic Weather Station of Ar

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Batalha, Isadora Maria, Camilo Andres P. Peña-Bello, and Luis Fernando F. Schütz. "PSV-4 Effects of Asprosin on Nuclear Sirtuins Expression in Bovine Granulosa Cells." Journal of Animal Science 101, Supplement_3 (2023): 403–4. http://dx.doi.org/10.1093/jas/skad281.479.

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Abstract Asprosin is an adipokine that regulates steroid production in granulosa cells (GC). Sirtuins are a family of NAD+-dependent deacetylases associated with GC function. In the nucleus, sirtuins are epigenetic regulators of gene expression. Although the literature shows that sirtuins and asprosin affect GC steroidogenesis and proliferation, studies are required to investigate whether their actions are linked. The aims of this study are to determine the influence of asprosin on mRNA expression of nuclear sirtuins and their association with steroidogenic regulators in bovine GC. GC were iso

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Santos, Lucas da Costa, Lucas Santos do Patrocínio Figueiró, Alex Xavier Ribeiro Andrade, Antônio Costa Ferreira Neto, and Caroline Salezzi Bonfá. "ESTUDO COMPARATIVO ENTRE METODOLOGIAS DE ESTIMATIVA DA EVAPOTRANSPIRAÇÃO DE REFERÊNCIA PARA LOCALIDADES DO NORTE DE MINAS GERAIS." IRRIGA 1, no. 4 (2021): 714–21. http://dx.doi.org/10.15809/irriga.2021v1n4p714-721.

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ESTUDO COMPARATIVO ENTRE METODOLOGIAS DE ESTIMATIVA DA EVAPOTRANSPIRAÇÃO DE REFERÊNCIA PARA LOCALIDADES DO NORTE DE MINAS GERAIS LUCAS DA COSTA SANTOS1; LUCAS SANTOS DO PATROCÍNIO FIGUEIRÓ1; ALEX XAVIER RIBEIRO DE ANDRADE1; ANTÔNIO COSTA FERREIRA NETO1 E CAROLINE SALEZZI BONFÁ1 1 Departamento de Agronomia, Universidade Federal dos Vales do Jequitinhonha e Mucuri – UFVJM, Campus JK, Rodovia MGT 367-KM 583, nº 5000, Alto da Jacuba. CEP: 39.100-000, Diamantina, Minas Gerais, Brasil. E-mail: lucas.santos@ufvjm.edu.br;lucas.figueiro@ufvjm.edu.br;alex.ribeiro@ufvjm.edu.br; antonio.costa@ufvjm.edu.br

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Palve, Vinayak C., Hannah L. Walker-Mimms, Ritu Chaudhary, et al. "Abstract 3368: Combination of a chk1/2 dual inhibitor (prexasertib) and gemcitabine reveals a novel intrinsic synergy mechanism in head and neck squamous cell carcinoma." Cancer Research 84, no. 6_Supplement (2024): 3368. http://dx.doi.org/10.1158/1538-7445.am2024-3368.

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Abstract Head and neck squamous cell carcinoma (HNSCC) presents a challenging clinical scenario due to its recurrence propensity despite existing treatments. Altered intrinsic signaling pathways significantly contribute to therapeutic resistance, demanding exploration of novel strategies to induce tumor cell demise. Dysregulated cell cycle and DNA damage repair constitute pivotal events driving HNSCC progression, offering potential therapeutic targets.CHK1 and CHK2, pivotal regulators of the DNA replication checkpoint, are promising targets in HNSCC. The convergence of DNA-damaging agents with

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Heathershaw, Tony. "Computational ocean acoustics. by F. B. Jensen, W. A. Kuperman, M. B. Porter and H. Schmidt. American institute of physics. 1994. pp. 634. price £70.00 (hardback). isbn 1 56396 209 8. Oceanography and acoustics: Prediction and propagation models. Edited by A. R. Robinson and D. Lee. American Institute of Physics. 1994. Pp. 300. Price £53.00 (hardback). ISBN 1 56396 203 9." Quarterly Journal of the Royal Meteorological Society 121, no. 525 (1995): 1179–81. http://dx.doi.org/10.1002/qj.49712152515.

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