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Relevant bibliographies by topics / R-methylation

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Academic literature on the topic 'R-methylation'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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Journal articles on the topic "R-methylation"

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Lin, Kaixin, Xiaolin Wang, Yanxin Luo, and Huichuan Yu. "Abstract 3485: Global DNA methylation level is associated with the sensitivity of cytotoxic and senotherapeutic drugs in gastrointestinal tumors." Cancer Research 84, no. 6_Supplement (2024): 3485. http://dx.doi.org/10.1158/1538-7445.am2024-3485.

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Abstract Background: Gastrointestinal cancer has become a severe burden around the world. Marker-guided treatment and clinical trials with sensitive anti-tumor drugs are critical for improving cancer survival. The decreasing DNA methylation levels of repetitive elements, such as LINE-1 and ALU, have been identified as the common biomarkers in cancer and aging. However, it remains unclear whether the methylation levels of repetitive elements can imply the drug sensitivity in gastrointestinal cancer. We investigated the association of LINE-1 and ALU methylations with the sensitivity of cytotoxic

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Saadatmand, Forough, Muneer Abbas, Victor Apprey, Krishma Tailor, and Bernard Kwabi-Addo. "Sex differences in saliva-based DNA methylation changes and environmental stressor in young African American adults." PLOS ONE 17, no. 9 (2022): e0273717. http://dx.doi.org/10.1371/journal.pone.0273717.

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Background Low socioeconomic status neighborhood exposure to stress and violence may be sources of negative stimuli that poses significant health risks for children, adolescents and throughout the life course of an individual. The study aims to investigate if aberrant epigenetic DNA methylation changes may be a potential mechanism for regulating neighborhood exposures and health outcomes. Methods Exposure to environmental stressors identified in 98 young African American (AA) adults aged 18–25 years old from the Washington D.C., area were used in the study. We correlated the association betwee

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Abula, Abudureyimu, Xiaona Li, Xing Quan, et al. "Molecular mechanism of RNase R substrate sensitivity for RNA ribose methylation." Nucleic Acids Research 49, no. 8 (2021): 4738–49. http://dx.doi.org/10.1093/nar/gkab202.

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Abstract RNA 2′-O-methylation is widely distributed and plays important roles in various cellular processes. Mycoplasma genitalium RNase R (MgR), a prokaryotic member of the RNase II/RNB family, is a 3′-5′ exoribonuclease and is particularly sensitive to RNA 2′-O-methylation. However, how RNase R interacts with various RNA species and exhibits remarkable sensitivity to substrate 2′-O-methyl modifications remains elusive. Here we report high-resolution crystal structures of MgR in apo form and in complex with various RNA substrates. The structural data together with extensive biochemical analys

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Walker, Elsbeth L. "Paramutation of the r1 Locus of Maize Is Associated With Increased Cytosine Methylation." Genetics 148, no. 4 (1998): 1973–81. http://dx.doi.org/10.1093/genetics/148.4.1973.

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Abstract In paramutation two alleles of a gene interact so that one of the alleles is epigenetically silenced. The silenced state is then genetically transmissible for many generations. The large (220 kbp) multigenic complex R-r is paramutable: its level of expression is changed during paramutation. R-r was found to exhibit increases in its level of cytosine methylation (C-methylation) following paramutation. These C-methylation changes are localized to the 5′ portions of the two genes in the complex that are most sensitive to paramutation. These methylation changes flank a small region called

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Barré-Villeneuve, Clément, and Jacinthe Azevedo-Favory. "R-Methylation in Plants: A Key Regulator of Plant Development and Response to the Environment." International Journal of Molecular Sciences 25, no. 18 (2024): 9937. http://dx.doi.org/10.3390/ijms25189937.

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Although arginine methylation (R-methylation) is one of the most important post-translational modifications (PTMs) conserved in eukaryotes, it has not been studied to the same extent as phosphorylation and ubiquitylation. Technical constraints, which are in the process of being resolved, may partly explain this lack of success. Our knowledge of R-methylation has recently evolved considerably, particularly in metazoans, where misregulation of the enzymes that deposit this PTM is implicated in several diseases and cancers. Indeed, the roles of R-methylation have been highlighted through the anal

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Li, Xiao-Hong, Mei-Yin Lu, Jia-Li Niu, Dong-Yan Zhu, and Bin Liu. "cfDNA Methylation Profiles and T-Cell Differentiation in Women with Endometrial Polyps." Cells 11, no. 24 (2022): 3989. http://dx.doi.org/10.3390/cells11243989.

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DNA methylation is a part of the regulatory mechanisms of gene expression, including chromatin remodeling and the activity of microRNAs, which are involved in the regulation of T-cell differentiation and function. However, the role of cfDNA methylation in T-cell differentiation is entirely unknown. In patients with endometrial polyps (EPs), we have found an imbalance of T-cell differentiation and an aberrant cfDNA methylation profile, respectively. In this study, we investigated the relationship between cfDNA methylation profiles and T-cell differentiation in 14 people with EPs and 27 healthy

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Vertino, Paula M., and Paul A. Wade. "R Loops: Lassoing DNA Methylation at CpGi." Molecular Cell 45, no. 6 (2012): 708–9. http://dx.doi.org/10.1016/j.molcel.2012.03.014.

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Karataş, Esra, Mehmet Gürbilek, and Gamze Demirel. "Relationship between Klotho gene methylation level and diet habit." Cukurova Medical Journal 49, no. 4 (2024): 965–73. https://doi.org/10.17826/cumj.1551174.

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Purpose: This study aimed to determine the relationship between the methylation level of the Klotho gene and nutritional habits. Materials and Methods: From our healthy sample group consisting of 20 people, two groups were created: 10 people fed with carbohydrates and 10 people had protein. Initially, a food consumption frequency determination form was administered as a survey to individuals. Based on the results of this survey, the amounts of food consumed by the participants (g/cc) were determined. According to the findings of the survey, two groups were formed: those classified as carbohydr

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Jiang, Xinyin, Chauntelle Jack-Roberts, Kaydine Edwards, Ella Gilboa, Ikhtiyor Djuraev, and Mudar Dalloul. "Association of Methylation-Related Nutrient Intake and Status with Offspring DNA Methylation in Pregnant Women with and Without Gestational Diabetes Mellitus." Current Developments in Nutrition 4, Supplement_2 (2020): 1016. http://dx.doi.org/10.1093/cdn/nzaa054_088.

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Abstract Objectives Gestational diabetes mellitus (GDM) is associated with alterations in DNA methylation in the placenta and offspring tissues. Nutrients participating in the methionine cycle (e.g., choline, betaine, folate, vitamin B12, methionine) influence the supply of methyl groups. The objective of this research was to determine whether maternal intake and status of these nutrients during pregnancy may interact with the GDM status to shape the offspring epigenome. Methods We conducted 3-day dietary recalls and collected blood samples from pregnant women with and without GDM (n = 22/grou

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Su, Shian, Quentin Gouil, Marnie E. Blewitt, Dianne Cook, Peter F. Hickey, and Matthew E. Ritchie. "NanoMethViz: An R/Bioconductor package for visualizing long-read methylation data." PLOS Computational Biology 17, no. 10 (2021): e1009524. http://dx.doi.org/10.1371/journal.pcbi.1009524.

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A key benefit of long-read nanopore sequencing technology is the ability to detect modified DNA bases, such as 5-methylcytosine. The lack of R/Bioconductor tools for the effective visualization of nanopore methylation profiles between samples from different experimental groups led us to develop the NanoMethViz R package. Our software can handle methylation output generated from a range of different methylation callers and manages large datasets using a compressed data format. To fully explore the methylation patterns in a dataset, NanoMethViz allows plotting of data at various resolutions. At

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Dissertations / Theses on the topic "R-methylation"

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Huska, Matthew R. [Verfasser]. "Using Machine Learning to Predict and Better Understand DNA Methylation and Genomic Enhancers / Matthew R. Huska." Berlin : Freie Universität Berlin, 2018. http://d-nb.info/1153007991/34.

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Bower, Edward Kenneth Merrick. "The evolution of restriction-modification systems." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/29528.

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Restriction Modification (R-M) systems prevent the invasion of foreign genetic material into bacterial cells and are therefore important in maintaining the integrity of the host genome. The spread of antibiotic resistance, which is proposed to occur via the transfer of foreign genes to the bacterial genome, makes the subject of R-M systems extremely relevant. R-M systems are currently classified into four types (I to IV) on the basis of differences in composition, target recognition, cofactors and the manner in which they cleave DNA. Kennaway et al (2012) proposed that there is an evolutionary

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MANIACI, MARIANNA. "THE ROLE OF PROTEIN ARGININE METHYLATION IN RBP-RNA INTERACTION MODULATION AND ITS IMPLICATIONS IN CANCER STRESS RESPONSE INVESTIGATED BY MS-PROTEOMICS." Doctoral thesis, Università degli Studi di Milano, 2022. https://hdl.handle.net/2434/946398.

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Various post-translational modifications (PTMs) have been described to regulate RNA-binding protein (RBP) activity, subcellular localization, and interactions with other proteins or RNAs. Proteome-wide experiments recently carried out in our group have shown that RBPs are the most abundant arginine (R)-methylated proteins. Protein Arginine Methyltransferases (PRMTs) are the enzymes responsible for the deposition of methylation on arginine. Recent evidence has indicated that R-hypomethylation could influence RBP phase-separation and consequent formation of Membrane-Less Organelles (MLOs). In my

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MacLeod, A. Robert (Robert Alan) 1966. "DNA methylation and oncogenesis." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=39956.

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DNA methylation is a postreplicative covalent modification of the DNA which is catalysed by the DNA methyltransferase enzyme. DNA methylation plays an important role in controlling the gene expression profile of mammalian cells. The hypothesis presented in this thesis is that the expression of the DNA methyltransferase gene is upregulated by cellular oncogenic pathways, and that this induction of MeTase activity results in DNA hypermethylation and plays a causal role in cellular transformation. Novel DNA methyltransferase inhibitors may inhibit the excessive activity of DNA methyltransferase i

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Tavares, de Araujo Felipe. "DNA replication and methylation." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37847.

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One of the main questions of modern biology is how our cells interpret our genetic and epigenetic information. DNA methylation is a covalent modification of the genome that is essential for mammalian development and plays an important role in the control of gene expression, genomic imprinting and X-chromosome inactivation (Bird and Wolffe, 1999; Szyf et al., 2000). Furthermore, changes in DNA methylation and DNA methyltransferase 1 (DNMT1) activity have been widely documented in a number of human cancers (Szyf, 1998a; Szyf et al., 2000).<br>In Escherichia coli, timing and frequency of initiati

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Chik, Pui Chi Flora. "Targeting the DNA methylation machinery in cancers." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114316.

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Cancer cells have aberrant DNA methylation patterns which are characterized by hypomethylation of a large set of promoters and hypermethylation of tumor suppressor genes. The dynamic nature of the epigenome makes it a valuable target for therapeutic interventions. This thesis focuses on understanding the use of various inhibitors towards DNA methylation-related proteins and their respective anti-cancer activities at both global and gene-specific levels. The widely used demethylating agent 5-azacytidine and 5-aza-2'-deoxycytidine (5-azaCdR) are FDA-approved drugs for the treatment of myelodyspl

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Boisvert, François-Michel. "A role for arginine methylation in DNA repair /." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85887.

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Arginine methylation is a post-translational modification occurring in higher eukaryotes that results in the addition of one or two methyl group on the nitrogen in the side chain of arginines. The enzymes responsible for protein arginine methylation have been classified in three groups. Type I enzymes promote the formation of both NG-monomethylated and asymmetric o-NG,NG-dimethylated arginines (aDMA). Type II enzymes catalyze the formation of monomethylated and symmetrical o-N G,N'G-dimethylated arginines (sDMA). The type III enzyme found in yeast catalyzes the monomethylation of the de

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Lucifero, Diana. "Developmental regulation of genomic imprinting by DNA methylation." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85573.

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Maintaining appropriate patterns of gene expression in the gametes and during early embryogenesis is essential for normal development. DNA methylation is an epigenetic means of regulating gene expression and is an important molecular mark regulating the sex-specific expression of genes subject to genomic imprinting. Imprinted genes are expressed from only one of two inherited chromosomes and are differentially marked during gametogenesis to allow for their parental allele specific expression. These genes affect embryo growth, placental function, behavior after birth and are implicated i

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Campbell, Paul Michael. "DNA methylation machinery as molecular targets for cancer therapeutics." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=82836.

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One of the elements commonly seen in cancer is the change in methylation status of the genome. These aberrations in methylation appear to be critical for the neoplastic phenotype and manifest as changes to gene expression of oncogenes and tumour suppressors. In addition to epigenetic alterations, the proteins involved in maintaining the plastic methylation status of the genome, DNA methyltransferases and demethylases, also show methylation-independent protein-protein interactions that have effects on cell cycle progression and proliferation. As changes in gene expression and mitotic reg

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Boulanger, Marie-Chloé. "Arginine methylation, the characterization of a post-translational modification." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85889.

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Proteins are known to be post-translationally modified. This thesis will discuss arginine methylation, one of the many post-translational modifications that occur within the cell. The enzymes that catalyze this post-translational modification are called arginine methyltransferases. The three main types of methylated arginines include monomethylated arginine (MMA), asymmetric dimethylated arginine (aDMA) and symmetric dimethylated arginines (sDMA). Type I arginine methyltransferases catalyze the formation of MMA and aDMA; Type II enzyme catalyze the formation of MMA and sDMA. Protein arg

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Books on the topic "R-methylation"

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Zhang, Hongmei. Analyzing High-Dimensional Gene Expression and DNA Methylation Data with R. Chapman and Hall/CRC, 2020. http://dx.doi.org/10.1201/9780429155192.

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Zhang, Hongmei. Analyzing High-Dimensional Gene Expression and DNA Methylation Data with R. Taylor & Francis Group, 2020.

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Analyzing High-Dimensional Gene Expression and DNA Methylation Data with R. Taylor & Francis Group, 2020.

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Zhang, Hongmei. Analyzing High-Dimensional Gene Expression and DNA Methylation Data with R. Taylor & Francis Group, 2020.

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Zhang, Hongmei. Analyzing High-Dimensional Gene Expression and DNA Methylation Data with R. Taylor & Francis Group, 2020.

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Zhang, Hongmei. Analyzing High-Dimensional Gene Expression and DNA Methylation Data with R. Taylor & Francis Group, 2020.

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Zhang, Hongmei. Analyzing High-Dimensional Gene Expression and DNA Methylation Data with R. Taylor & Francis Group, 2020.

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Book chapters on the topic "R-methylation"

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Catoni, Marco, and Nicolae Radu Zabet. "Analysis of Plant DNA Methylation Profiles Using R." In Methods in Molecular Biology. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1134-0_21.

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Zhang, Hongmei. "Introduction." In Analyzing High-Dimensional Gene Expression and DNA Methylation Data with R. Chapman and Hall/CRC, 2020. http://dx.doi.org/10.1201/9780429155192-1.

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Zhang, Hongmei. "Genome-scale gene expression data." In Analyzing High-Dimensional Gene Expression and DNA Methylation Data with R. Chapman and Hall/CRC, 2020. http://dx.doi.org/10.1201/9780429155192-2.

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Zhang, Hongmei. "Genome-scale epigenetic data." In Analyzing High-Dimensional Gene Expression and DNA Methylation Data with R. Chapman and Hall/CRC, 2020. http://dx.doi.org/10.1201/9780429155192-3.

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Zhang, Hongmei. "Screening genome-scale genetic and epigenetic data." In Analyzing High-Dimensional Gene Expression and DNA Methylation Data with R. Chapman and Hall/CRC, 2020. http://dx.doi.org/10.1201/9780429155192-4.

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Zhang, Hongmei. "Cluster Analysis in Data mining." In Analyzing High-Dimensional Gene Expression and DNA Methylation Data with R. Chapman and Hall/CRC, 2020. http://dx.doi.org/10.1201/9780429155192-5.

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Zhang, Hongmei. "Methods to select genetic and epigenetic factors based on linear associations." In Analyzing High-Dimensional Gene Expression and DNA Methylation Data with R. Chapman and Hall/CRC, 2020. http://dx.doi.org/10.1201/9780429155192-6.

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Zhang, Hongmei. "Non- and semi-parametric methods to select genetic and epigenetic factors." In Analyzing High-Dimensional Gene Expression and DNA Methylation Data with R. Chapman and Hall/CRC, 2020. http://dx.doi.org/10.1201/9780429155192-7.

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Zhang, Hongmei. "Network construction and analyses." In Analyzing High-Dimensional Gene Expression and DNA Methylation Data with R. Chapman and Hall/CRC, 2020. http://dx.doi.org/10.1201/9780429155192-8.

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Curry, Edward. "Analyzing DNA Methylation Microarray Data in R." In Introduction to Bioinformatics with R. Chapman and Hall/CRC, 2020. http://dx.doi.org/10.1201/9781351015318-9.

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Conference papers on the topic "R-methylation"

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Almeida, V., SN Chehimi, GFS Carvalho, et al. "DIFFERENCE IN METHYLATION STATUS OF REMAINING ALLELE IN SIBLINGS WITH THE SAME DELETION SIZE IN 5P." In Resumos do 54º Congresso Brasileiro de Patologia Clínica/Medicina Laboratorial. Zeppelini Editorial e Comunicação, 2022. http://dx.doi.org/10.5327/1516-3180.140s1.6429.

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Objective: Cri Du Chat syndrome or 5psyndrome (OMIM #123450) is characterized by a genomic loss in the short arm of chromosome 5 and by variable clinical manifestations, that include high-pitched cry in newborns. The phenotypic variability in this syndrome may not be limited only to variations in gene structure – such as deletions, duplications, inversions, insertions and translocations – as DNA methylation mechanisms, which occurs mainly in the “CpG Islands”, are also possible. Therefore, we studied the methylation status of the remaining allele of region of breakpoint at 5pin siblings, an 11

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Kulikowski, LD, G. Carvalho, YG Oliveira, et al. "METHYLATION AND BIOLOGICAL AGE ANALYSIS IN ADHD PATIENTS." In Resumos do 54º Congresso Brasileiro de Patologia Clínica/Medicina Laboratorial. Zeppelini Editorial e Comunicação, 2022. http://dx.doi.org/10.5327/1516-3180.140s1.5854.

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Objective: Attention deficit/hyperactivity disorder (ADHD) is a common behavioral syndrome that begins in childhood and affects 3.4% of children worldwide. Due to its etiological complexity, there are no consistent biomarkers for ADHD, however the high heritability that the disorder presents indicates an influence of genetic/ epigenetic factors. The main epigenetic mechanisms is DNA methylation, a process with an important role in gene expression and in many biological pathways. Methylation status can be used as a biomarker for clinical conditions, such as cancer and neuropsychiatric diseases

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