Relevant bibliographies by topics / R-PK11195

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'R-PK11195'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'R-PK11195.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "R-PK11195"

1

Bitker, Laurent, Nicolas Costes, Didier Le Bars, et al. "Noninvasive quantification of macrophagic lung recruitment during experimental ventilation-induced lung injury." Journal of Applied Physiology 127, no. 2 (2019): 546–58. http://dx.doi.org/10.1152/japplphysiol.00825.2018.

Full text
Abstract:
Macrophagic lung infiltration is pivotal in the development of lung biotrauma because of ventilation-induced lung injury (VILI). We assessed the performance of [11C](R)-PK11195, a positron emission tomography (PET) radiotracer binding the translocator protein, to quantify macrophage lung recruitment during experimental VILI. Pigs ( n = 6) were mechanically ventilated under general anesthesia, using protective ventilation settings (baseline). Experimental VILI was performed by titrating tidal volume to reach a transpulmonary end-inspiratory pressure (∆PL) of 35–40 cmH2O. We acquired PET/compute
APA, Harvard, Vancouver, ISO, and other styles
2

Kobayashi, Masato, Teresa Jiang, Sanjay Telu, et al. "11C-DPA-713 has much greater specific binding to translocator protein 18 kDa (TSPO) in human brain than 11C-(R)-PK11195." Journal of Cerebral Blood Flow & Metabolism 38, no. 3 (2017): 393–403. http://dx.doi.org/10.1177/0271678x17699223.

Full text
Abstract:
Positron emission tomography (PET) radioligands for translocator protein 18 kDa (TSPO) are widely used to measure neuroinflammation, but controversy exists whether second-generation radioligands are superior to the prototypical agent 11C-( R)-PK11195 in human imaging. This study sought to quantitatively measure the “signal to background” ratio (assessed as binding potential ( BPND)) of 11C-( R)-PK11195 compared to one of the most promising second-generation radioligands, 11C-DPA-713. Healthy subjects had dynamic PET scans and arterial blood measurements of radioligand after injection of either
APA, Harvard, Vancouver, ISO, and other styles
3

de Souza, Aline Morais, Caroline Cristiano Real, Mara de Souza Junqueira, et al. "Potential of [11C](R)-PK11195 PET Imaging for Evaluating Tumor Inflammation: A Murine Mammary Tumor Model." Pharmaceutics 14, no. 12 (2022): 2715. http://dx.doi.org/10.3390/pharmaceutics14122715.

Full text
Abstract:
Background: Breast tumor inflammation is an immunological process that occurs mainly by mediation of Tumor-Associated Macrophages (TAM). Aiming for a specific measurement of tumor inflammation, the current study evaluated the potential of Positron Emission Tomography (PET) imaging with [11C](R)-PK11195 to evaluate tumor inflammation in a mammary tumor animal model. Methods: Female Balb/C mice were inoculated with 4T1 cells. The PET imaging with [11C](R)-PK11195 and [18F]FDG was acquired 3 days, 1 week, and 2 weeks after cell inoculation. Results: The [11C](R)-PK11195 tumor uptake increased fro
APA, Harvard, Vancouver, ISO, and other styles
4

Su, Zhangjie, Federico Roncaroli, Pascal F. Durrenberger, et al. "The 18-kDa Mitochondrial Translocator Protein in Human Gliomas: A 11C-(R)PK11195 PET Imaging and Neuropathology Study." Journal of Nuclear Medicine 56, no. 4 (2015): 512–7. https://doi.org/10.2967/jnumed.114.151621.

Full text
Abstract:
The 18-kDa mitochondrial translocator protein (TSPO) is up-regulated in high grade astrocytomas and can be imaged by positron emission tomography (PET) using the selective radiotracer 11C-(R)PK11195. We investigated 11C-(R)PK11195 binding in human gliomas and its relationship with TSPO expression in tumor tissue and glioma associated microglia/macrophages within the tumors. METHODS: Twenty-two glioma patients underwent dynamic 11C-(R)PK11195 PET scans and perfusion MRI acquisition. Parametric maps of 11C-(R)PK11195 binding potential (BPND) were generated. Co-registered
APA, Harvard, Vancouver, ISO, and other styles
5

Boutin, Hervé, Katie Murray, Jesus Pradillo, et al. "[18F]GE-180: a novel TSPO radiotracer compared to [11C]PK11195 in a preclinical model of stroke." Eur J Nucl Med Mol Imaging 42, no. 3 (2014): 503–11. https://doi.org/10.1007/s00259-014-2939-8.

Full text
Abstract:
PURPOSE: Neuroinflammation plays a critical role in various neuropathological conditions, and hence there is renewed interest in the translocator protein (TSPO) as a biomarker of microglial activation and macrophage infiltration in the brain. This is reflected in the large amount of research conducted seeking to replace the prototypical PET radiotracer 11C-R-PK11195 with a TSPO ligand with higher performance. Here we report the in vivo preclinical investigation of the novel TSPO tracer 18F-GE-180 in a rat model of stroke. METHODS: Focal cerebral ischaemia was induced in Wistar rats by 60-min o
APA, Harvard, Vancouver, ISO, and other styles
6

Alfaifi, B., E. Agushi, R. Hinz, A. Jackson, D. Lewis, and D. Coope. "P15.10.A USE OF DUAL TRACERS PET AS A PREDICTIVE BIOMARKER OF THE SITE OF RECURRENCE IN HIGH GRADE GLIOMA." Neuro-Oncology 25, Supplement_2 (2023): ii111—ii112. http://dx.doi.org/10.1093/neuonc/noad137.374.

Full text
Abstract:
Abstract BACKGROUND High grade glioma has poor survival rate and tumour recurrence occurs despite current treatments. Positron emission tomography (PET) with [11C](R)PK11195 can evaluate translocator protein (TSPO) and [11C]methionine can assess amino acid transport. PET imaging might have the potential to detect tumour regions at baseline that will later develop as the site of recurrence. We compare TSPO measured using [11C](R)PK11195 and amino acid transport using [11C]methionine at baseline and investigate to what extend the two tracers can predict the site of tumour recurrence. MATERIAL AN
APA, Harvard, Vancouver, ISO, and other styles
7

Schuck, Phelipi Nunes, Caroline Machado Dartora, and Ana Maria Marques da Silva. "Geração de Imagens PET Estáticas com [11C]-(R)-PK11195: Definição do Intervalo Temporal." Revista Brasileira de Física Médica 11, no. 2 (2017): 25. http://dx.doi.org/10.29384/rbfm.2017.v11.n2.p25-29.

Full text
Abstract:
O radiotraçador [11C]-(R)-PK11195 mostra afinidade com a microglia em imagens PET in vivo e vem sendo utilizado como indicador de doença inflamatória cerebral, como a esclerose múltipla (EM). Atualmente, não há consenso sobre o intervalo temporal adequado para gerar imagens PET estáticas com [11C]-(R)-PK11195. O objetivo deste trabalho é determinar o intervalo temporal mais adequado para a geração de imagens PET cerebrais estáticas adquiridas com [11C]-(R)-PK11195 para a quantificação. Foram geradas imagens PET estáticas com [11C]-(R)-PK11195 nos intervalos de: 0-60min, 5-20min, 5-30min, 10-60
APA, Harvard, Vancouver, ISO, and other styles
8

Gent, Yoony Y. J., Nazanin Ahmadi, Alexandre E. Voskuyl, et al. "Detection of Subclinical Synovitis with Macrophage Targeting and Positron Emission Tomography in Patients with Rheumatoid Arthritis without Clinical Arthritis." Journal of Rheumatology 41, no. 11 (2014): 2145–52. http://dx.doi.org/10.3899/jrheum.140059.

Full text
Abstract:
Objective.To determine whether macrophage targeting by (R)-11C-PK11195 positron emission tomography (PET) can visualize subclinical joint inflammation in patients with rheumatoid arthritis (RA) without clinical arthritis during or after treatment, with flare as clinical outcome measure.Methods.(R)-11C-PK11195 PET and contrast-enhanced magnetic resonance imaging (MRI) of hands/wrists were performed in 29 patients with RA without clinical arthritis. (R)-11C-PK11195 PET uptake (semiquantitative score 0–3) in metacarpophalangeal, proximal interphalangeal, and wrist joints (i.e., 22 joints per pati
APA, Harvard, Vancouver, ISO, and other styles
9

Gerhard, Alexander. "In-vivo-Bildgebung "neuroinflammatorischer Veränderungen" mit PET; Grundlagen und Anwendung bei Parkinson-Syndromen In vivo Imaging of "Neuroinflammatory Changes" with PET; Background and Applications in Parkinsonian disorders." Nuklearmediziner 39, no. 04 (2016): 309–15. https://doi.org/10.1055/s-0042-113849.

Full text
Abstract:
<strong>Zusammenfassung</strong> &nbsp; Mikroglia sind residente immunkompetente Zellen des Gehirns, die durch unspezifische Sch&auml;digung aktiviert werden. Im aktivierten Zustand exprimieren sie das &bdquo;translocator protein 18&thinsp;kD&ldquo; (TSPO) &ndash; fr&uuml;her peripherer Benzodiazepinrezeptor genannt, an welches hochspezifisch das Isoquinolin PK11195 bindet. Radioaktiv markiert kann das R-Enantiomer [<sup>11</sup>C] PK11195 als Ligand in der Positronenemissionstomografie (PET) genutzt werden und erm&ouml;glicht so die in-vivo-Darstellung &bdquo;aktiver&ldquo; neuroinflammatoris
APA, Harvard, Vancouver, ISO, and other styles
10

Kitade, Makoto, Hideaki Nakajima, Tetsuya Tsujikawa, et al. "Evaluation of (R)-[11C]PK11195 PET/MRI for Spinal Cord-Related Neuropathic Pain in Patients with Cervical Spinal Disorders." Journal of Clinical Medicine 12, no. 1 (2022): 116. http://dx.doi.org/10.3390/jcm12010116.

Full text
Abstract:
Activated microglia are involved in secondary injury after acute spinal cord injury (SCI) and in development of spinal cord-related neuropathic pain (NeP). The aim of the study was to assess expression of translocator protein 18 kDa (TSPO) as an indicator of microglial activation and to investigate visualization of the dynamics of activated microglia in the injured spinal cord using PET imaging with (R)-[11C]PK11195, a specific ligand for TSPO. In SCI chimeric animal models, TSPO was expressed mainly in activated microglia. Accumulation of (R)-[3H]PK11195 was confirmed in autoradiography and i
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "R-PK11195"

1

Narciso, Lucas Diovani Lopes. "Avalia??o de m?todos de quantifica??o de imagens PET com [11C]-(R)-PK11195 na investiga??o da esclerose m?ltipla." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2016. http://tede2.pucrs.br/tede2/handle/tede/7072.

Full text
Abstract:
Submitted by Setor de Tratamento da Informa??o - BC/PUCRS (tede2@pucrs.br) on 2016-12-01T15:49:46Z No. of bitstreams: 1 DIS_LUCAS_DIOVANI_LOPES_NARCISO_COMPLETO.pdf: 3232892 bytes, checksum: bde72a06ddadae90febae5d048b0471c (MD5)<br>Made available in DSpace on 2016-12-01T15:49:46Z (GMT). No. of bitstreams: 1 DIS_LUCAS_DIOVANI_LOPES_NARCISO_COMPLETO.pdf: 3232892 bytes, checksum: bde72a06ddadae90febae5d048b0471c (MD5) Previous issue date: 2016-08-31<br>The activation of microglia is an important response to inflammatory processes in the central nervous system (CNS). There has been an increase
APA, Harvard, Vancouver, ISO, and other styles
2

Alba, Marcos Vin?cius Fortes. "Desenvolvimento do processo de s?ntese e dos ensaios de controle de qualidade do radiof?rmaco [??C]-(R)-PK11195 no Centro de Produ??o de Radiof?rmacos do Instituto do C?rebro/RS para utiliza??o em PET/CT." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2016. http://tede2.pucrs.br/tede2/handle/tede/6855.

Full text
Abstract:
Submitted by Setor de Tratamento da Informa??o - BC/PUCRS (tede2@pucrs.br) on 2016-07-26T14:25:23Z No. of bitstreams: 1 DIS_MARCOS_VINICIUS_FORTES_ALBA_COMPLETO.pdf: 1333852 bytes, checksum: c687fbcabc052faa5ed3567c986640e9 (MD5)<br>Made available in DSpace on 2016-07-26T14:25:23Z (GMT). No. of bitstreams: 1 DIS_MARCOS_VINICIUS_FORTES_ALBA_COMPLETO.pdf: 1333852 bytes, checksum: c687fbcabc052faa5ed3567c986640e9 (MD5) Previous issue date: 2016-02-15<br>Nuclear Medicine enables, among other things, the visualization, characterization and quantification of biochemical processes, metabolism, biom
APA, Harvard, Vancouver, ISO, and other styles
3

Alves, Vítor Hugo Pereira. "Optimisation of synthesis, purification and reformulation of (R)-[N-methyl-¹¹C] PK11195 for in vivo PET imaging studies." Master's thesis, 2012. http://hdl.handle.net/10316/26005.

Full text
Abstract:
A inflamação, em geral, é uma resposta fisiológica do corpo para com diferentes tipos de lesão do tecido, provocando uma cascata coordenada de reacções celulares e bioquímicas. Distúrbios neurodegenerativos, inflamatórios e neoplásicos envolvem reacções neuroinflamatórias que isolam o tecido danificado e promovem respostas imunitárias. Da mesma forma, a neuroinflamação (NI) implica uma complexa e orquestrada resposta a vários estímulos no sistema nervoso central (SNC), com vista para a preservação do tecido e sua restauração. Reacções neuroin
APA, Harvard, Vancouver, ISO, and other styles
4

Pais, Marta Silva Lapo. "Machine Learning Classification in Alzheimer’s disease based on 11C-Pittsburgh Compound B (PiB) and 11C-(R)-PK11195 (PK) PET imaging measures and the correlation between these two biomarkers." Master's thesis, 2019. http://hdl.handle.net/10316/87968.

Full text
Abstract:
Trabalho de Projeto do Mestrado Integrado em Engenharia Biomédica apresentado à Faculdade de Ciências e Tecnologia<br>A doença de Alzheimer (AD) é a doença neurodegenerativa responsável pelo maior número de casos de demência. Tomografia por emissão de positrões (PET) com 11C-Pittsburgh Compound B (PiB) e 11C-(R)-PK11195 (PK) são duas modalidades utilizadas na visualização das placas amilóides e da microglia ativada no cérebro humano, respetivamente. Uma vez que as placas amilóides são o principal identificador da AD e que a microglia ativada é também recorrentemente encontrada no cérebro dos
APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "R-PK11195"

1

Alves, Vítor H., Antero J. Abrunhosa, and Miguel Castelo-Branco. "Synthesis of (R)-[N-Methyl-11C]PK11195." In Radiochemical Syntheses. John Wiley & Sons, Inc, 2015. http://dx.doi.org/10.1002/9781118834114.ch10.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Cagnin, A., A. Gerhard, and R. B. Banati. "The Concept of In Vivo Imaging of Neuroinflammation with [11C](R)-PK11195 PET." In Neuroinflammation — From Bench to Bedside. Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/978-3-662-05073-6_10.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Salvi de Souza, Giordana, and Ana Maria Marques da Silva. "Investigation of Time-Activity Curve Behavior in Dynamic [11C]-(R)-PK11195 PET in Cortical Brain Regions: Preliminary Results." In IFMBE Proceedings. Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-9023-3_127.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

MYERS, RALPH, RICHARD B. BÁNATI, ERALDO PAULESU, JOHN THORPE, DAVID H. MILLER, and TERRY JONES. "Use of Two- and Three-Dimensional PET and [ 11 C](R)-PK11195 to Image Focal and Regional Brain Pathology 1 1Transcripts of the BRAINPET97 discussion of this chapter can be found in Section VIII." In Quantitative Functional Brain Imaging with Positron Emission Tomography. Elsevier, 1998. http://dx.doi.org/10.1016/b978-012161340-2/50031-7.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "R-PK11195"

1

Hinz, Rainer, Ronald Boellaard, and Federico E. Turkheimer. "In how many kinetic classes can [11C]-(R)-PK11195 brain PET data be segmented?" In 2008 IEEE Nuclear Science Symposium and Medical Imaging conference (2008 NSS/MIC). IEEE, 2008. http://dx.doi.org/10.1109/nssmic.2008.4774272.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Alves, Vitor H., Antero J. Abrunhosa, and Miguel Castelo-Branco. "Optimisation of synthesis, purification and reformulation of (R)-[N-Methyl-11C]PK11195 for in vivo PET imaging studies." In 2013 IEEE 3rd Portuguese Meeting in Bioengineering (ENBENG). IEEE, 2013. http://dx.doi.org/10.1109/enbeng.2013.6518428.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Boellaard, Ronald, Federico E. Turkheimer, Rainer Hinz, et al. "Performance of a modified supervised cluster algorithm for extracting reference region input functions from (R)-[11C]PK11195 brain PET studies." In 2008 IEEE Nuclear Science Symposium and Medical Imaging conference (2008 NSS/MIC). IEEE, 2008. http://dx.doi.org/10.1109/nssmic.2008.4774453.

Full text
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'R-PK11195' for particular source types:
Journal articles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography