Relevant bibliographies by topics / Ra445

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  2. Dissertations / Theses
  3. Books

Academic literature on the topic 'Ra445'

Author: Grafiati
Published: 28 July 2024
Last updated: 31 July 2025

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Journal articles on the topic "Ra445"

1

Anchoori, Ravi K., Ssu-Hsueh Tseng, Hua-Ling Tsai, Vikrant Palande, Michelle A. Rudek, and Richard B. S. Roden. "Preclinical studies of RA475, a guanidine-substituted spirocyclic candidate RPN13/ADRM1 inhibitor for treatment of ovarian cancer." PLOS ONE 19, no. 7 (2024): e0305710. http://dx.doi.org/10.1371/journal.pone.0305710.

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There is an urgent unmet need for more targeted and effective treatments for advanced epithelial ovarian cancer (EOC). The emergence of drug resistance is a particular challenge, but small molecule covalent inhibitors have promise for difficult targets and appear less prone to resistance. Michael acceptors are covalent inhibitors that form bonds with cysteines or other nucleophilic residues in the target protein. However, many are categorized as pan-assay interference compounds (PAINS) and considered unsuitable as drugs due to their tendency to react non-specifically. Targeting RPN13/ADRM1-med
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Tsukuba, Takayuki, Yu Yamaguchi, and Tomoko Kadowaki. "Large Rab GTPases: Novel Membrane Trafficking Regulators with a Calcium Sensor and Functional Domains." International Journal of Molecular Sciences 22, no. 14 (2021): 7691. http://dx.doi.org/10.3390/ijms22147691.

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Rab GTPases are major coordinators of intracellular membrane trafficking, including vesicle transport, membrane fission, tethering, docking, and fusion events. Rab GTPases are roughly divided into two groups: conventional “small” Rab GTPases and atypical “large” Rab GTPases that have been recently reported. Some members of large Rab GTPases in mammals include Rab44, Rab45/RASEF, and Rab46. The genes of these large Rab GTPases commonly encode an amino-terminal EF-hand domain, coiled-coil domain, and the carboxyl-terminal Rab GTPase domain. A common feature of large Rab GTPases is that they expr
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3

Wang, Yuxiao, Walter Huynh, Taylor D. Skokan, Wen Lu, Arthur Weiss, and Ronald D. Vale. "CRACR2a is a calcium-activated dynein adaptor protein that regulates endocytic traffic." Journal of Cell Biology 218, no. 5 (2019): 1619–33. http://dx.doi.org/10.1083/jcb.201806097.

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Cytoplasmic dynein is a minus end–directed microtubule motor that transports intracellular cargoes. Transport is initiated by coiled-coil adaptors that (a) join dynein and its cofactor dynactin into a motile complex and (b) interact with a cargo-bound receptor, which is frequently a Rab GTPase on an organelle. Here, we report two novel dynein adaptors, CRACR2a and Rab45, that have a coiled-coil adaptor domain, a pair of EF-hands, and a Rab GTPase fused into a single polypeptide. CRACR2a-mediated, but not Rab45-mediated, dynein motility is activated by calcium in vitro. In Jurkat T cells, eleva
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Nakamura, S., T. Takemura, L. Tan, et al. "Small GTPase RAB45-mediated p38 activation in apoptosis of chronic myeloid leukemia progenitor cells." Carcinogenesis 32, no. 12 (2011): 1758–72. http://dx.doi.org/10.1093/carcin/bgr205.

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Shintani, Mami, Minoru Tada, Tetsuo Kobayashi, Hiroaki Kajiho, Kenji Kontani, and Toshiaki Katada. "Characterization of Rab45/RASEF containing EF-hand domain and a coiled-coil motif as a self-associating GTPase." Biochemical and Biophysical Research Communications 357, no. 3 (2007): 661–67. http://dx.doi.org/10.1016/j.bbrc.2007.03.206.

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Sato, Keiko, Tomoko Kadowaki, Mamoru Takenaka, et al. "RASEF/Rab45 regulates the formation and sorting of zymogen granules and secretion of digestive enzymes by pancreatic acinar cells." Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, June 2024, 167310. http://dx.doi.org/10.1016/j.bbadis.2024.167310.

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Tagmazian, Arina A., Claudia Schwarz, Catharina Lange, Esa Pitkänen, and Eero Vuoksimaa. "ArcheD, a residual neural network for prediction of cerebrospinal fluid amyloid‐beta from amyloid PET images." European Journal of Neuroscience, April 4, 2024. http://dx.doi.org/10.1111/ejn.16332.

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AbstractDetection and measurement of amyloid‐beta (Aβ) in the brain is a key factor for early identification and diagnosis of Alzheimer's disease (AD). We aimed to develop a deep learning model to predict Aβ cerebrospinal fluid (CSF) concentration directly from amyloid PET images, independent of tracers, brain reference regions or preselected regions of interest. We used 1870 Aβ PET images and CSF measurements to train and validate a convolutional neural network (“ArcheD”). We evaluated the ArcheD performance in relation to episodic memory and the standardized uptake value ratio (SUVR) of cort
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Dissertations / Theses on the topic "Ra445"

1

Mills, Hayley. "A mixed method investigation into the perception and measurement of success in the Healthwise Exercise Referral Scheme." Thesis, University of Gloucestershire, 2008. http://eprints.glos.ac.uk/3173/.

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Liu, Lixun. "Exploring ethnic inequalities in cardiovascular disease using Hospital Episode Statistics." Thesis, St Andrews, 2009. http://hdl.handle.net/10023/819.

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Ryan, Judith Mary. "Reducing pain and disability for patients with chronic neck pain : results of a double-blind randomised controlled trial comparing strength to endurance training." Phd thesis, 2001. http://hdl.handle.net/1885/110010.

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Neck pain is a common musculo-skeletal problem in the industrialised world with fifty to ninety percent of people experiencing one or more episodes of neck pain during their lifetime. The majority recover quickly from these episodes, but five percent of all cases persist for more than three months. The recurrence rate is high at sixty-percent. The cost to the individual in terms of reduced earning capacity and personal and family distress is very high. The cost to society in terms of lost productivity and compensation payouts is reported to be substantial. Thus, there are very compelling·
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4

Hinde, Sarah Jane. "The road rules : a Bourdieuian analysis of the social reproduction of health inequalities and transport practices in Melbourne." Phd thesis, 2008. http://hdl.handle.net/1885/150561.

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Books on the topic "Ra445"

1

Roy, Amara, Robert Wood Johnson Foundation, and Institute for the Future, eds. Health and health care 2010: The forecast, the challenge. Jossey-Bass, 2000.

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Jodi, Brookins-Fisher, ed. Community health in the 21st century. Allyn and Bacon, 1997.

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3

1933-, Basch Paul F., ed. Textbook of international health. Oxford University Press, 1990.

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1952-, Griffiths Siân, and Hunter David J, eds. New perspectives in public health. 2nd ed. Radcliffe, 2007.

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5

1949-, Caine Dennis John, Caine Caroline G. 1945-, Lindner Koenraad J. 1941-, and Epidemiology of Sports Injuries Symposium (1994 : Champaign, Ill.), eds. Epidemiology of sports injuries. Human Kinetics, 1996.

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1962-, Lee Kelley, Buse Kent, and Fustukian Suzanne 1953-, eds. Health policy in a globalising world. Cambridge University Press, 2002.

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Kent, Buse, Hein Wolfgang 1949-, and Drager Nick, eds. Making sense of global health governance: A policy perspective. Palgrave Macmillan, 2009.

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8

1954-, Johnson James A., and Stoskopf Carleen, eds. Comparative health care systems: Global perspectives. Jones and Bartlett Publishers, 2010.

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9

1927-, Harrison G. A., Waterlow J. C, and International Commission on Anthropology of Food and Food Problems., eds. Diet and disease: In traditional and developing societies. Cambridge University Press, 1990.

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W, Kreuter Marshall, and Green Lawrence W, eds. Health program planning: An educational and ecological approach. 4th ed. McGraw-Hill, 2005.

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