Relevant bibliographies by topics / Rabāb

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Rabāb'

Author: Grafiati
Published: 4 June 2021
Last updated: 18 June 2025

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Journal articles on the topic "Rabāb"

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Anand, Shashi, Mohammad Aslam Khan, Moh’d Khushman, Santanu Dasgupta, Seema Singh, and Ajay Pratap Singh. "Comprehensive Analysis of Expression, Clinicopathological Association and Potential Prognostic Significance of RABs in Pancreatic Cancer." International Journal of Molecular Sciences 21, no. 15 (2020): 5580. http://dx.doi.org/10.3390/ijms21155580.

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RAB proteins (RABs) represent the largest subfamily of Ras-like small GTPases that regulate a wide variety of endosomal membrane transport pathways. Their aberrant expression has been demonstrated in various malignancies and implicated in pathogenesis. Using The Cancer Genome Atlas (TCGA) database, we analyzed the differential expression and clinicopathological association of RAB genes in pancreatic ductal adenocarcinoma (PDAC). Of the 62 RAB genes analyzed, five (RAB3A, RAB26, RAB25, RAB21, and RAB22A) exhibited statistically significant upregulation, while five (RAB6B, RAB8B, RABL2A, RABL2B, and RAB32) were downregulated in PDAC as compared to the normal pancreas. Racially disparate expression was also reported for RAB3A, RAB25, and RAB26. However, no clear trend of altered expression was observed with increasing stage and grade, age, and gender of the patients. PDAC from occasional drinkers had significantly higher expression of RAB21 compared to daily or weekly drinkers, whereas RAB25 expression was significantly higher in social drinkers, compared to occasional ones. The expression of RABL2A was significantly reduced in PDAC from diabetic patients, whereas RAB26 was significantly lower in pancreatitis patients. More importantly, a significant association of high expression of RAB21, RAB22A, and RAB25, and low expression of RAB6B, RABL2A, and RABL2B was observed with poorer survival of PC patients. Together, our study suggests potential diagnostic and prognostic significance of RABs in PDAC, warranting further investigations to define their functional and mechanistic significance.
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Tasaka, K., N. Masumoto, J. Mizuki, et al. "Rab3B is essential for GnRH-induced gonadotrophin release from anterior pituitary cells." Journal of Endocrinology 157, no. 2 (1998): 267–74. http://dx.doi.org/10.1677/joe.0.1570267.

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Gonadotrophin-releasing hormone (GnRH) induces the release of gonadotrophins via an increase in cytosolic Ca2+ concentration ([Ca2+]). Rab3B, a member of the small GTP-binding protein Rab family, is known to be involved in Ca(2+)-regulated exocytosis in pituitary cells. However, it is not known whether Rab3B functions in the physiological process regulated by GnRH in gonadotrophs. In this study using antisense oligonucleotide against Rab3B (AS-Rab3B) we determined that Rab3B is involved in GnRH-induced gonadotrophin release. Rab3B immunopositive cells were reduced in 24% of pituitary cells by AS-Rab3B. This treatment did not affect the population of gonadotrophs or the intracellular contents of gonadotrophins. However, AS-Rab3B significantly inhibited the total amount of basal and GnRH-induced gonadotrophin released from pituitary cells. These results show that Rab3B is involved in basal and GnRH-induced gonadotrophins release but not the storage of gonadotrophins. Next, the changes in [Ca2+] and exocytosis in gonadotrophs treated with AS-Rab3B were compared among Rab3B-positive and -negative cells. The change in [Ca2+] was not different in the two groups, but exocytosis was significantly inhibited in Rab3B-negative cells. These results suggest that Rab3B is essential for GnRH-regulated exocytosis downstream of cytosolic Ca2+ in gonadotrophs.
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Wong, Wing Hei, Stephanie Z. Liu, Annie Shi Ru Li, Xingyou Liu, Morris F. Manolson, and Ralph A. Zirngibl. "Evidence for Rab7b and Its Splice Isoforms Having Distinct Biological Functions from Rab7a." International Journal of Molecular Sciences 26, no. 6 (2025): 2610. https://doi.org/10.3390/ijms26062610.

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The Rab family of small guanosine triphosphatases (GTPases) are nucleotide-dependent switches. Mutations in Rabs can result in human diseases. Rab7a and Rab7b transition from early endosomes to lysosomes and are presumed to function similarly. Most studies look at Rab7a, less on Rab7b, with the underlying assumption they function similarly. There have yet to be articles comparing them side by side. Whilst cloning Rab7 homologues, we identified splice isoforms for Rab7b only. These splice isoforms, Rab7b2 and Rab7bx8 lacking different exons, have not been previously characterized but suggest alternative function(s) for Rab7b. Thus, we hypothesize that Rab7 homologues have distinct functions. Here, we compare Rab7a and Rab7b nucleotide mutants locked in GDP-bound (Rab7T22N), GTP-bound (Rab7Q67L), nucleotide-free (Rab7aN125I/Rab7bN124I) states and characterized localization of the Rab7b splice isoforms. HeLa cells were transiently transfected with fluorescently tagged Rab7 reporters. Confocal images were processed with ImageJ and analyzed with SPSS. Rab7a and Rab7b nucleotide mutants were significantly different to one another. Approximately 50% of Rab7b splice isoform-expressing cells had aggregated vesicles, which were phenotypically different from Rab7b vesicles. Rab7a and Rab7b vesicles shared approximately 60% colocalization with each other, while Rab7b vesicles preferentially localized to the Trans Golgi Network. Our results suggest Rab7b is distinct from Rab7a, and Rab7b splice isoforms have different biological functions.
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Aulia Pratama Ricardo and Wimbrayardi Wimbrayardi. "Deskriptif Proses Pembuatan Alat Musik Rabab Pasisia di Painan Timur Kabupaten Pesisir Selatan." Imajinasi : Jurnal Ilmu Pengetahuan, Seni, dan Teknologi 1, no. 2 (2024): 10–23. http://dx.doi.org/10.62383/imajinasi.v1i2.127.

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The process of making traditional musical instruments Rabab Pasisia in South Pesisir Regency. This study aims to describe the process of making Rabab Pasisia musical instruments. The approach used is a qualitative approach with a descriptive type of research. This research was conducted with data collection techniques used are observation, interview and documentation techniques. Data analysis techniques are carried out by reducing, presenting data and verifying this data aims to find out the structure, process, manufacturing techniques, playing techniques, from Rabab Pasisia. This musical instrument is made of jariang wood and has different tones, and uses several types of wood. The results of this study show that the parts and stages of the process of making traditional Rabab Pasisia musical instruments include: wooden mangkapatiah for Rabab bodies, sketching rabab patterns, making rabab tongues, installing rabab friction nylon, making rabab kudo-kudo, and how to produce sounds, tuning systems on traditional Rabab Pasisia musical instruments. The instruments used in the process of making traditional musical instruments Gandang Tambua include: Lantiak Knife (containing rabab tongue), Kapatiah (forming rabab body), Cutting Saw, Hammer (Stick), Measuring instrument (meter), Pencil, Sandpaper, Scissors. The ingredients are; Jariang Wood (45Cm Long, 30Cm Wide, and 4Cm Thick), Montiah Wood (Meranti), Sicerek Wood, Shell, Rope, Nails and, Wood glue. The process of making Rabab Pasisia musical instruments includes several stages, namely: 1) The process of making the body (jariang wood), until the finishing of fine and rough sanding, 2) The process of installing nylon on the rabab frictioner, 3) The process of installing squirrels, kudo-kudo, talingo and rabab strings for tuning the tone.
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Parwati, Silpa, and Harisnal Hadi. "PENGARUH PERTUNJUKAN ORGEN TUNGGAL TERHADAP EKSISTENSI RABAB PASISIA DI KEC. LENGAYANG KABUPATEN PESISIR SELATAN." Jurnal Sendratasik 9, no. 4 (2020): 45. http://dx.doi.org/10.24036/jsu.v9i1.109539.

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This study aims to find and describe the effect of Orgen Tunggal performance on the existence of Rabab Pasisiain Kambang Village, Lengayang District, South Pesisir Regency. This is a qualitative research using a descriptivemethod. The main instrument in this study was the researcher it self and was assisted by supporting instruments such as writing instruments and cameras. The data were collected through literature study, observation, interview, and documentation. The steps for analyzing the data are collecting the data, describing the data, and making conclusions. The results show that Orgen Tunggal performance can affect the existence of Rabab Pasisia in Kambang Village community, Lengayang District, South Pesisir Regency. Nowadays, people no longer understand the messages contained in Rabab, and Rababis viewed as entertainment only. There are factors which influence the existence of RababPasisia. Internally, the community more likely enjoys Orgen Tunggal. The people no longer understand the education value in Rabab, so it makes Rabab Pasisia unattractive. Externally, modernization and globalization rises. The existence of Orgen Tunggal which is increasingly popular in the community of KambangVillage, Lengayang District, affects the existence of Rabab as traditional entertainment which has moral messages.Gradually it also affects the intensity of Rabab performance on the community who enjoys Rabab, on messages Rabab delivers, on the existence of Rabab, and on the performance of Rabab. Rabab undergoes a few updates so that it still exists and is favored by the community. One of which is a form of Raun Sabalik which has pleasant rhythms.Keywords: influence, single orgen, the existence of rabab pasisia
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Meng, Tong. "CSIG-35. RAB3B DICTATES MTORC1/S6 SIGNALING IN CHORDOMA AND PREDICTS RESPONSE TO MTORC1-TARGETED THERAPY." Neuro-Oncology 26, Supplement_8 (2024): viii71. http://dx.doi.org/10.1093/neuonc/noae165.0284.

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Abstract Chordoma is a rare mesenchymal malignancy, exhibiting a high tendency to postoperative recurrence and poor prognosis. To date, its tumorigenic regulatory mechanisms remain elusive leading to a lack of effective therapeutic targets and drug sensitivity indicators. Here, via transcriptome and proteome analyses, we unveiled RAB3B as the prominent oncogenic regulator in chordoma. Multidimensional tissue samples further indicated its overexpression and enhancer-associated high transcriptional activity in chordoma. Notably, RAB3B ablation attenuated the chordoma cell growth, stemness, migration and tumorigenicity in vivo and in vitro. Through determining the RAB3B-mediated program in chordoma, we identified that RAB3B was highly associated with PI3K-AKT-mTOR signaling and directly bound to S6. Mechanistically, RAB3B increased the S6K-mediated phosphorylation of S6 by physically interacting with dephosphorylase DUSP12, to block its dephosphorylating of p-S6 specifically at S235/236. Pharmacological targeting mTORC1 pathway via dactolisib and rapamycin dramatically impeded the RAB3B-induced chordoma cell oncogenesis, while RAB3B knockout desensitized mTORC1 inhibition. Clinically, RAB3B/p-S6 suggested a good prognostic value and response to mTORC1 inhibitors for chordoma patients. Altogether, this work uncovers RAB3B as a novel activator of mTORC1 pathway, and suggests the oncogenic and predictive roles of RAB3B/p-S6 in chordoma, indicating therapeutic potentials of mTORC1-targeted therapy in advanced chordoma patients with aberrant RAB3B/p-S6 hyperactivation.
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Zhang, Yiwen, Zhen Yang, Ke Dai, et al. "Rab4b Promotes Cytolethal Distending Toxin from Glaesserella parasuis-Induced Cytotoxicity in PK-15 Cells." Toxins 16, no. 9 (2024): 407. http://dx.doi.org/10.3390/toxins16090407.

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Glaesserella parasuis cytolethal distending toxin (GpCDT) can induce cell cycle arrest and apoptosis. Our laboratory’s previous work demonstrated that GTPase 4b (Rab4b) is a key host protein implicated in GpCDT-induced cytotoxicity. This study investigated the probable involvement of Rab4b in the process. Our study used CRISPR/Cas9 technology to create a Rab4b-knockout cell line. The results showed greater resistance to GpCDT-induced cell cytotoxicity. In contrast, forced Rab4b overexpression increased GpCDT-induced cytotoxicity. Further immunoprecipitation study reveals that GpCDT may bind with Rab4b. In PK-15 cells, GpCDT is transported to the early endosomes and late endosomes, while after knocking out Rab4b, GpCDT cannot be transported to the early endosome via vesicles. Rab4b appears essential for GpCDT-induced cytotoxicity in PK-15 cells.
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Monetta, Pablo, Ileana Slavin, Nahuel Romero, and Cecilia Alvarez. "Rab1b Interacts with GBF1 and Modulates both ARF1 Dynamics and COPI Association." Molecular Biology of the Cell 18, no. 7 (2007): 2400–2410. http://dx.doi.org/10.1091/mbc.e06-11-1005.

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Assembly of the cytosolic coat protein I (COPI) complex at the ER–Golgi interface is directed by the ADP ribosylation factor1 (Arf1) and its guanine nucleotide exchange factor (GBF1). Rab1b GTPase modulates COPI recruitment, but the molecular mechanism underlying this action remains unclear. Our data reveal that in vivo expression of the GTP-restricted Rab1b mutant (Rab1Q67L) increased the association of GBF1 and COPI to peripheral structures localized at the ER exit sites (ERES) interface. Active Rab1b also stabilized Arf1 on Golgi membranes. Furthermore, we characterized GBF1 as a new Rab1b effector, and showed that its N-terminal domain was involved in this interaction. Rab1b small interfering RNA oligonucleotide assays suggested that Rab1b was required for GBF1 membrane association. To further understand how Rab1b functions in ER-to-Golgi transport, we analyzed GFP-Rab1b dynamics in HeLa cells. Time-lapse microscopy indicated that the majority of the Rab1b-labeled punctuated structures are relatively short-lived with limited-range movements. FRAP of Golgi GFP-Rab1bwt showed rapid recovery (t1/2 120 s) with minimal dependence on microtubules. Our data support a model where Rab1b-GTP induces GBF1 recruitment at the ERES interface and at the Golgi complex where it is required for COPII/COPI exchange or COPI vesicle formation, respectively.
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Maiben alpandi and Zulkarnain Mistortoify. "TUKANG RABAB DAN KABA RABAB PASISIA DALAM ACARA BARALEK DI NAGARI TALAO." Sorai: Jurnal Pengkajian dan Penciptaan Musik 17, no. 1 (2024): 45–54. http://dx.doi.org/10.33153/sorai.v17i1.6074.

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The study "Tukang Rabab dan Kaba Rabab Pasisia dalam Acara Baralek di Nagari Talao, Sumatra Barat" explores the competencies and presentation of kaba rabab pasisia in baralek events. This performance reveals the richness of Minangkabau culture, from a warm opening to a meaningful core story. Through poetic lyrics and captivating music, Kaba enriches understanding of Minangkabau cultural values. Tukang Rabab, as cultural guardians, adeptly perform rabab pasisia and master Minangkabau language and literature. Social interaction is key to their competence, living within the community of rabab pasisia artists and exchanging knowledge and skills. Despite facing modernization challenges, the art of rabab pasisia remains relevant and valuable. The participation of tukang rabab in cultural events, art training, and preservation projects strengthens Minangkabau identity and cultural heritage. This performance fosters community solidarity and serves as a platform for learning life values, enriching and preserving Minangkabau cultural identity, and encouraging the younger generation to uphold ancestral traditions
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Zhao, Qin, Chang Miao, Yi-Ting Chen, et al. "Host Factor Rab4b Promotes Japanese Encephalitis Virus Replication." Microorganisms 12, no. 9 (2024): 1804. http://dx.doi.org/10.3390/microorganisms12091804.

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Although the Japanese encephalitis virus (JEV) infects various cell types, its receptor molecules are still not clearly understood. In our laboratory’s prior research, Rab4b was identified as a potential host factor that facilitates JEV infection in PK15 cells, utilizing a genome-wide CRISPR/Cas9 knockout library (PK-15-GeCKO). To further explore the effect of Rab4b on JEV replication, we used the Rab4b knockout PK15 cell line using the CRISPR/Cas9 technology and overexpressing the Rab4b PK15 cell line, with IFA, RT–qPCR, and Western blot to study the effect of Rab4b on viral replication in the whole life cycle of the JEV. The results show that the knockout of Rab4b inhibited the replication of the JEV in PK15 cells, and the overexpression of Rab4b promoted the replication of the JEV in PK15 cell lines. Furthermore, we demonstrated for the first time that host factor Rab4b facilitates the adsorption, internalization, assembly, and release of the JEV, thereby promoting JEV replication. This study enriches the regulatory network between the JEV and host factors and lays the experimental foundation for further understanding of the function of the Rab4b protein.
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Dissertations / Theses on the topic "Rabāb"

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Khalifa, Mohamed. "Approches organologiques et musicales des rebabs de l’Afrique du nord et du Moyen-Orient." Thesis, Paris 4, 2016. http://www.theses.fr/2016PA040159.

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Ancêtre du rebec médiéval, emblème de la musique arabo-andalouse ou encore instrument favori des bédouins arabes pour l’accompagnement de leurs récits et de leurs poèmes, le rebab, sous ses différentes variantes joue encore plusieurs fonctions et rôles qui diffèrent d’un peuple à l’autre et d’une région à une autre. Cette thèse a pour but l’étude approfondie des rebabs de l’Afrique du nord et du Moyen-Orient. Chaque variante de cet instrument est étudiée sur plus d’un plan : historique, organologique, musical et même acoustique. La classification et la muséologie de cet instrument, avec ses différentes variantes, sont aussi abordées dans ce travail. L’intérêt de cette thèse, réside dans l’étude approfondie des différents types de cet instrument, ainsi qu’aux liens existants entre eux, car nous pensons qu’aujourd’hui, tout comme pour le sujet du ‘ūd ou tout autre instrument, il faudrait avoir une approche scientifique globale sur le sujet du rebab<br>Ancestor of the medieval rebec, the emblem of the Arab-Andalusian music or the favorite instrument of the Arabics Bedouins for the accompaniment of their narratives and their poems, the rebab, under its various variants, still plays several roles and functions which differ from each people and each region. This thesis aims at the in-depth study of the rebabs of North Africa and the Middle East. Every variant of this instrument is studied on more than a plan: history, organology, musical and even acoustic. The classification and the museology of this instrument, with its various variants, are also approached on this work. The interest of this thesis, lives in the in-depth study of the various types of this instrument, as well as in the existing links between them, because we think that today, as for the 'ud or any other instrument, it would be necessary to have a global scientific approach about the rebab
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Ghazzī, Muḥammad ibn Qāsim Khatrūshī Imḥammad al-Mabrūk Ibn Mālik Muḥammad ibn ʻAbd Allāh. "Fatḥ al-Rabb al-Mālik bi-sharḥ Alfīyat Ibn Mālik." Ṭarābulus, al-Jamāhīrīyah al-ʻUẓmá : Kullīyat al-Daʻwah al-Islāmīyah wa-Lajnat al-Ḥifāẓ ʻalá al-Turāth al-Islāmī, 1991. http://catalog.hathitrust.org/api/volumes/oclc/29873051.html.

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Bouget, Gwenaëlle. "Implication de la petite GTPase Rab4b des lymphocytes T dans les complications métaboliques de l’obésité." Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2018. http://theses.univ-cotedazur.fr/2018AZUR4050.

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Lors de l’obésité, les défauts d’expansion du tissu adipeux blanc sont à l’origine des désordres métaboliques. Lorsque les adipocytes atteignent leurs capacités maximales de stockage de triglycérides, des dépôts ectopiques de lipides apparaissent dans le foie et le muscle conduisant à la résistance à l’insuline. De plus, les adipocytes dysfonctionnels sécrètent des facteurs d’alertes établissant une inflammation dans le tissu adipeux. Cette inflammation est médiée par les communications entre les adipocytes et les cellules immunitaires qui sont contrôlées par l’endocytose et le trafic intracellulaire. L’endocytose et les protéines Rab gouvernant ce processus pourraient être des éléments clés de l’expansion du tissu adipeux. L’équipe a démontré que l’expression de Rab4b était diminuée dans le tissu adipeux de patients obèses diabétiques et de souris obèses. Nos travaux montrent que l’expression de Rab4b est diminuée dans les lymphocytes T du tissu adipeux de souris et de patients obèses. L’invalidation de Rab4b dans les lymphocytes T in vivo induit une résistance à l’insuline et une accumulation d’acides gras dans le foie et dans le muscle sous régime normal. Ces défauts sont dus à une inhibition de l’adipogenèse par l’IL-6 et l’IL-17, limitant l’expansion du tissu adipeux. L’augmentation de ces cytokines pro-inflammatoires est une conséquence de l’augmentation du nombre de lymphocytes Th17 et une diminution des lymphocytes T régulateurs. Nous décrivons un nouveau mécanisme par lequel l’expression de Rab4b dans les lymphocytes T régule les complications métaboliques de l’obésité en changeant les sous-populations de cellules immunitaires dans le tissu adipeux<br>Expendability defect of adipose tissue during obesity is at the basis of obesity-related metabolic complications. Indeed, when adipocytes reach their maximal triglyceride storage capacity, ectopic lipid depots are appearing in liver and muscles, leading to insulin resistance. Moreover, dysfunctional adipocytes secrete alarming factors leading to adipose tissue inflammation. This inflammation is sustained by adipocytes and immune cells communications that are controlled by endocytosis and intracellular trafficking. Endocytosis and its governing proteins, the Rab GTPases, could be pivotal in the regulation of adipose tissue expandability. Our team has demonstrated that Rab4b expression is reduced in obese diabetic patients and mice adipose tissues. The present work demonstrates that Rab4b is decreased in adipose tissue T cells in both obese patient and mice. The depletion of Rab4b in T cells in vivo leads to insulin resistance and lipid accumulation in liver and muscles under normal diet. These defects are due to adipogenesis inhibition by IL-6 and IL-17, which limits adipose tissue expansion. These pro-inflammatory cytokines are increased in adipose tissue of the mice depleted for Rab4b in T cells because the number of Th17 is increased at the expense of the number of regulatory T cells. We describe here a new mechanism in which Rab4b expression in T cells control obesity-related metabolic complications by tuning T cells subpopulations in adipose tissue
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Bouget, Gwenaëlle. "Implication de la petite GTPase Rab4b des lymphocytes T dans les complications métaboliques de l’obésité." Thesis, Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR4050/document.

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Lors de l’obésité, les défauts d’expansion du tissu adipeux blanc sont à l’origine des désordres métaboliques. Lorsque les adipocytes atteignent leurs capacités maximales de stockage de triglycérides, des dépôts ectopiques de lipides apparaissent dans le foie et le muscle conduisant à la résistance à l’insuline. De plus, les adipocytes dysfonctionnels sécrètent des facteurs d’alertes établissant une inflammation dans le tissu adipeux. Cette inflammation est médiée par les communications entre les adipocytes et les cellules immunitaires qui sont contrôlées par l’endocytose et le trafic intracellulaire. L’endocytose et les protéines Rab gouvernant ce processus pourraient être des éléments clés de l’expansion du tissu adipeux. L’équipe a démontré que l’expression de Rab4b était diminuée dans le tissu adipeux de patients obèses diabétiques et de souris obèses. Nos travaux montrent que l’expression de Rab4b est diminuée dans les lymphocytes T du tissu adipeux de souris et de patients obèses. L’invalidation de Rab4b dans les lymphocytes T in vivo induit une résistance à l’insuline et une accumulation d’acides gras dans le foie et dans le muscle sous régime normal. Ces défauts sont dus à une inhibition de l’adipogenèse par l’IL-6 et l’IL-17, limitant l’expansion du tissu adipeux. L’augmentation de ces cytokines pro-inflammatoires est une conséquence de l’augmentation du nombre de lymphocytes Th17 et une diminution des lymphocytes T régulateurs. Nous décrivons un nouveau mécanisme par lequel l’expression de Rab4b dans les lymphocytes T régule les complications métaboliques de l’obésité en changeant les sous-populations de cellules immunitaires dans le tissu adipeux<br>Expendability defect of adipose tissue during obesity is at the basis of obesity-related metabolic complications. Indeed, when adipocytes reach their maximal triglyceride storage capacity, ectopic lipid depots are appearing in liver and muscles, leading to insulin resistance. Moreover, dysfunctional adipocytes secrete alarming factors leading to adipose tissue inflammation. This inflammation is sustained by adipocytes and immune cells communications that are controlled by endocytosis and intracellular trafficking. Endocytosis and its governing proteins, the Rab GTPases, could be pivotal in the regulation of adipose tissue expandability. Our team has demonstrated that Rab4b expression is reduced in obese diabetic patients and mice adipose tissues. The present work demonstrates that Rab4b is decreased in adipose tissue T cells in both obese patient and mice. The depletion of Rab4b in T cells in vivo leads to insulin resistance and lipid accumulation in liver and muscles under normal diet. These defects are due to adipogenesis inhibition by IL-6 and IL-17, which limits adipose tissue expansion. These pro-inflammatory cytokines are increased in adipose tissue of the mice depleted for Rab4b in T cells because the number of Th17 is increased at the expense of the number of regulatory T cells. We describe here a new mechanism in which Rab4b expression in T cells control obesity-related metabolic complications by tuning T cells subpopulations in adipose tissue
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Khairat, Ibrahim Abdelhay Rabab [Verfasser], and Nikolaus [Akademischer Betreuer] Blin. "Next generation sequencing of DNA extracted from mummified tissue / Rabab Khairat Ibrahim Abdelhay ; Betreuer: Nikolaus Blin." Tübingen : Universitätsbibliothek Tübingen, 2013. http://d-nb.info/1162844647/34.

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Kulkarni, Rewa M. "CO-LOCALIZATION OF POLYCYSTIC OVARY SYNDROME CANDIDATE GENE PRODUCTS IN HUMAN THECA CELLS SUGGESTS NOVEL SIGNALING PATHWAYS." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5741.

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Polycystic ovary syndrome (PCOS) is the leading cause of anovulatory infertility and the most common endocrinopathy of women of reproductive age. Genome-wide association studies (GWAS) identified a number of loci associated PCOS in different ethnic populations, including women with Asian and European ancestry. Replication studies have confirmed some of these associations. Among the loci identified are those located near the LH receptor gene (LHCGR), a clathrin-binding protein gene (DENND1A) that also functions as a guanine nucleotide exchange factor, and the gene encoding RAB5B, a GTPase and protein involved in vesicular trafficking. The functional significance of one of these GWAS candidates (DENND1A) was supported by our discovery that a truncated protein splice variant of DENND1A termed DENND1A.V2, is elevated in PCOS theca cells, and that forced expression of DENND1A.V2 in normal theca cells increased CYP11A1 and CYP17A1 expression and androgen synthesis, a hallmark of PCOS. We previously proposed that the PCOS GWAS loci could be assembled into a functional network that contributes to altered gene expression in ovarian theca cells, resulting in increased androgen synthesis. Here we demonstrate the localization of LHCGR, DENND1AV.2 and RAB5B proteins in various cellular compartments in normal and PCOS theca cells. hCG and forskolin stimulation affects the distribution and co-localization of DENND1A.V2 and RAB5B in various cellular compartments This cytological evidence supports our PCOS gene network concept, and raises the intriguing possibility that LHCGR activation, via a cAMP-mediated process, promotes the translocation of DENND1A.V2 and RAB5B-containing vesicles from the PCOS theca cell cytoplasm into the nucleus, resulting in increased transcription of genes involved in androgen synthesis.
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Zasimczuk, Ivan A. "Maxwell M. Rabb : a hidden hand of the Eisenhower administration in civil rights and race relations." Thesis, Manhattan, Kan. : Kansas State University, 2008. http://hdl.handle.net/2097/753.

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Abdelaleem, Rabab Gamal Helmi [Verfasser], Stefan H. [Akademischer Betreuer] Heinemann, Gerhard K. E. [Akademischer Betreuer] Scriba, and Roland [Akademischer Betreuer] Seifert. "Methionine sulfoxide reductases of Aspergillus nidulans / Rabab Gamal Helmi Abdelaleem. Gutachter: Stefan H. Heinemann ; Gerhard K. E. Scriba ; Roland Seifert." Jena : Thüringer Universitäts- und Landesbibliothek Jena, 2014. http://d-nb.info/106253624X/34.

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Morsy, Rabab Salah Mohamed [Verfasser], Christa [Akademischer Betreuer] Reicher, and Dietwald [Gutachter] Gruehn. "Ecotourism as a framework for sustainable touristic development: case study of protected areas, Egypt / Rabab Salah Mohamed Morsy. Betreuer: Christa Reicher. Gutachter: Dietwald Gruehn." Dortmund : Universitätsbibliothek Dortmund, 2015. http://d-nb.info/1110893744/34.

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Echard, Arnaud. "Etude fonctionnelle de 3 isoformes de la gtpase rab6. Caracterisation de rabkinesine-6, une nouvelle kinesine golgienne interagissant specifiquement avec les isoformes rab6a et rab6b." Paris 11, 2000. http://www.theses.fr/2000PA112157.

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La gtpase rab6a est une proteine rab associee aux membranes de l'appareil de golgi et regule le trafic membranaire entre le golgi et le reticulum endoplasmique dans les cellules de mammiferes. J'ai clone et caracterise un moteur moleculaire dependant des microtubules, baptise rabkinesine-6, qui interagit specifiquement avec les formes liees au gtp de rab6a. J'ai montre que cette proteine est localisee a la surface du golgi et qu'il s'agit biochimiquement d'un nouveau membre de la superfamille des kinesines. Rabkinesine-6 depourvue de son domaine moteur a de plus un effet dominant negatif sur la fonction de rab6a dans le transport intracellulaire. Ces resultats suggerent que rabkinesine-6 pourrait fournir la force necessaire pour deplacer le long des microtubules les structures tubulo-vesiculaires marquees par rab6a que nous avons observees en videomicroscopie. Par ailleurs, une isoforme appelee rab6b, a ete identifiee specifiquement dans le cerveau et pourrait jouer un role similaire a rab6a dans ce tissu. Enfin, j'ai etudie la fonction dans le trafic intracellulaire retrograde d'un variant alternatif de rab6a denomme rab6a. Cette proteine est le premier exemple d'une isoforme aussi similaire dans la famille des proteines rab (seulement trois acides amines de difference). De facon surprenante, rab6a a une fonction proche mais distincte de celle de rab6a, et pourrait intervenir uniquement dans la regulation du trafic intra-golgien. Des etudes de mutagenese montrent que la fonction de rab6a dans le transport retrograde entre le golgi et le reticulum endoplasmique requiert une interaction avec rabkinesine-6. L'ensemble de ces resultats suggerent un lien direct entre la machinerie des proteines rab et les moteur moleculaires, et permettent d'expliquer le controle vectoriel du trafic intracellulaire par ces gtpases.
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Books on the topic "Rabāb"

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Tarīn, Ḥanīf. Rabāb-i ṣahrā. Zīr-i Ihtimām Tavāzun Pablīkeshanz, 1992.

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Īsapzay, Abū Adam. Rabāb, tāl aw ahang. Mafkūrah, 2020.

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Mumtāz, Mahdī Sayyid, ред. Rang o rabāb: Majmūʻah-yi kalām. Manjū Qamar Maimorial Kamīṭī, 2005.

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Sukerta, Pande Made. Learning the Balinese rebab. Bali Mangsi Foundation, 2000.

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Amīn, ʻAlī. Yā Rabb. al-ʻAṣr al-Ḥadīth, 1987.

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Amīn, ʻAlī. Yā Rabb. al-ʻAṣr al-Ḥadīth, 1987.

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Dhavida, Usria. Kesenian rabab pesisir. Museum Negeri Propinsi Sumatera Barat "Adhityawarman,", 1996.

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Raina, Amrit Kaur. Dūjā rabābī Maradānā̃. Lokgeet Parkashan, 2012.

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Farīd, Zāhī, ред. Thulāthīyat al-Rabāṭ. al-Rābiṭah, 1998.

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Nāṣir, Muḥammad. Fī raḥāb Allah: Shʻir. al-Muʾassasah al-Wataniyah lil-Funūn al-Maṭbaʻah, 1991.

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Book chapters on the topic "Rabāb"

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Leppla, Norman C., Bastiaan M. Drees, Allan T. Showler, et al. "Rabb, Robert Lamar." In Encyclopedia of Entomology. Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6359-6_3281.

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Bucci, Cecilia, and Marino Zerial. "Rab4b." In Guidebook to the Sinall GTPases. Oxford University PressOxford, 1995. http://dx.doi.org/10.1093/oso/9780198599456.003.0093.

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Abstract Rab4b was identified by Chavrier etal. (1990), screening an MDCKII cell cDNA library with an oligonucleotide corresponding to the amino acid sequence WDTAGQE, which is shared by members of the Rab and Rho protein subfamilies (Valencia 1991). The nucleotide sequence and the predicted amino acid sequence are shown in Fig. 1(A). Northern blot analysis revealed a single ∼2 kb messenger RNA that was expressed in BHK21, MDCKII and NIH3T3 cell lines. The GenBank accession number is X56389.
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Kikuchi, Akira, and Yoshimi Takai. "Rab3b." In Guidebook to the Sinall GTPases. Oxford University PressOxford, 1995. http://dx.doi.org/10.1093/oso/9780198599456.003.0089.

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Abstract Bovine Rab3b cDNA was isolated from a bovine brain cDNA library using oligonucleotide probes of Rab3a (Matsui etal. 1988). Human Rab3b cDNA was isolated from a human pheochromocytoma cDNA library by use of human Rab3a cDNA as a probe (Zahraoui et al. 1989). The nucleotide sequence of bovine Rab3b and its deduced amino acid sequence are shown in Fig. 1. The GenBank accession numbers are: bovine Rab3b, J03943; human Rab3b, J03000.
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Sawa, George Dimitri. "The Characteristics of the Rabāb from the Book of Ibn al-Ṭaḥḥān [fols. 80–82; al-Sillāmī 201–202]". У <i>Mutʿat al-asmāʿ fī ʿilm al-samāʿ<i>, The Ears’ Pleasure and the Science of Listening to Music by Aḥmad b. Yūsuf al-Tīfāshī al-Qafṣī (580-651/1184-1253). BRILL, 2023. http://dx.doi.org/10.1163/9789004542785_037.

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"Mention of the ṭunbūr, miʿzafa, rabāb, mizmār, ṭabl, urghun, qīthāra, sulyāq, duff, ṣalīkh, and kankala [fols. 105a–106a; ZY 114–6]". У Ḥāwī l-Funūn wa-Salwat al-Maḥzūn, Encompasser of the Arts and Consoler of the Grief-Stricken by Ibn al-Ṭaḥḥān. BRILL, 2021. http://dx.doi.org/10.1163/9789004465497_106.

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"Rab3 protein family." In Secretory Pathway, edited by Jonathan Rothblatt, Peter Novick, and Tom H. Stevens. Oxford University PressOxford, 1994. http://dx.doi.org/10.1093/oso/9780198599425.003.0125.

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Abstract The cDNA sequences of rab3A (smg p25A)1,2,3, rab3B (smg p25B)3A and rab3C (smg p25C)3 predict proteins of 25.0 kDa, 24.7 kDa and 26.0 kDa, respectively (GenBank accession numbers M19885, M19886, and M19887). Com-parison of the bovine sequences revealed that rab3A shares 77% amino acid sequence identity with rab3B and 85% with rab3C. Rab3B and rab3C exhibit 80% sequence identity. In addition, a Drosophila homolog has been cloned and sequenced5 that is slightly more related to rab3A (78% identity) than to rab3B (76% identity), demonstrating a high degree of evolutionary conservation.
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Bucci, Cecilia, Anne Liitcke, Paul Dupree, and Marino Zerial. "Rab5b and Rab5c." In Guidebook to the Sinall GTPases. Oxford University PressOxford, 1995. http://dx.doi.org/10.1093/oso/9780198599456.003.0095.

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Abstract Rab5b and Rab5c were identified by Chavrier etal. (1992), using a PCR approach to amplify Rab proteins from embryonic day 17 mouse kidney cDNA. The two oligonucleotides used corresponded to the GXXXXGKS/T and to the WDTAGQE conserved regions. Using modified RACE protocols (Frohman et al. 1988; Walker et al. 1992), cDNA clones encoding Rab5b and Rab5c from mouse kidney RNA were identified. Rab5b was also independently cloned from a human endothelial cDNA library (Wilson and Wilson 1992).
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"Rabab al-Omri." In Embrace on Brooklyn Bridge. The American University in Cairo Press, 2017. http://dx.doi.org/10.2307/j.ctv2ks6zgb.8.

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Plakane, Guna. "Latvijas Komunistiskās partijas satelītorganizācijas 20. gadsimta 20. gados: Rīgas Arodbiedrību centrālbiroja piemērs." In Jauno vēsturnieku zinātniskie lasījumi VI. LU Akadēmiskais apgāds, 2021. http://dx.doi.org/10.22364/jvzl.06.03.

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Nozīmīgākā galēji kreisā PSRS atbalstītā organizācija starpkaru Latvijā bija Latvijas Komunistiskā partija (LKP). Tā kā komunistiskām organizācijām Latvijā legāli darboties bija aizliegts, LKP darbojās pagrīdē. Lai vairotu savu ietekmi sabiedrībā, LKP iefiltrējās legālās biedrībās, kā arī dibināja formāli patstāvīgas organizācijas, kas bija politiski atkarīgas no LKP. Rakstā sniegts ieskats LKP satelītorganizāciju darbībā 20. gadsimta 20. gados, izmantojot Rīgas Arodbiedrību centrālbiroja (RABCB) piemēru. RABCB visos tā darbības virzienos vērsās pret pastāvošo valsts iekārtu, iestājās par radikāliem risinājumiem sociālajā un politiskajā jomā un ciešiem sakariem ar PSRS. LKP ar RABCB starpniecību nodrošināja pieeju plašākām sabiedrības aprindām, kas deva iespēju dažādos veidos izvērst nelegālās organizācijas propagandu.
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Balch, William E. "Rabla, b." In Guidebook to the Sinall GTPases. Oxford University PressOxford, 1995. http://dx.doi.org/10.1093/oso/9780198599456.003.0086.

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Abstract Rabla and 1 b isoforms have been identified by the screening of cDNA libraries from mouse, rat, human and canine sources using oligonucleotide probes specific to Rasrelated proteins (Haubruck etal. 1987; Touchot etal. 1987; Wagner eta/. 1987; Tachibana etal. 1988; Vielh eta/. 1989; Wichmann etal. 1989; Zahraoui etal. 1989; Chavrier eta/. 1990, 1992). The nucleotide sequence of the rat Rabla (Touchot et al. 1987) and the rat Rablb (Wichmann et al. 1989) isoforms are shown in Fig. 1. GenBank accession numbers are J02998 (Rabla) and X13905 (Rablb).
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Conference papers on the topic "Rabāb"

1

Zehm, C., R. Waterstradt, and S. Baltrusch. "Expression und Funktion von Rab3B in murinen und humanen Beta-Zellen des Pankreas." In Diabetes Kongress 2019 – 54. Jahrestagung der DDG. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1688117.

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Madaan, Sanya, and Pravir Kumar. "Stilbostemin C as a Potential Candidate for Therapeutic Targeting of Rab3b Protein in Countering Alzheimers." In 2023 6th International Conference on Information Systems and Computer Networks (ISCON). IEEE, 2023. http://dx.doi.org/10.1109/iscon57294.2023.10112094.

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Yang, Xian-Zi, Ren Wang, Xiao-Xing Li, Yang Yang, Hui-Yun Wang, and X. F. Steven Zheng. "Abstract 1029: Rab1A and Rab1B promote esophageal squamous cell carcinoma through activating mTORC1 signaling and inhibiting autophagy." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-1029.

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Jiang, HongLin, Hefen Sun та Wei Jin. "Abstract P1-07-18: Loss of Rab1B promotes triple-negative breast cancer metastasis by activating TGF-β/Smad signaling". У Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium; December 9-13, 2014; San Antonio, TX. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.sabcs14-p1-07-18.

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Hoffmann, Nathan E., Bo H. Chao, and John C. Bischof. "Cryo, Hyper or Both? Investigating Combination Cryo/Hyperthermia in the Dorsal Skin Flap Chamber." In ASME 2000 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/imece2000-2239.

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Abstract Combination therapies have been investigated as a mean to increase efficacy of disease treatment. For example, combinations such as radiation and chemotherapy, surgery and chemotherapy, and two different chemotherapies have become standard treatment for most cancers. Current theories suggest that vascular-mediated injury is an important mechanism of cryosurgical (reviewed in Gage and Baust (1998)) and hyperthermic destruction (Badylak et al., 1985; Dudar and Jain, 1984) in the treatment of solid tumors. These techniques appear complementary. Freezing creates vascular damage and promotes stasis within the vessels (Rabb et al., 1974), whereas hyperthermia creates cell and vascular destruction more effectively with a compromised vasculature (Shakil et al., 1999). Thus, in this study, we investigated the effect of combining these therapies on the vascular and tissue injury from the two therapies. We chose the dorsal skin flap chamber (DSFC) implanted in the Copenhagen rat as the cryosurgical model for this study. This in vivo freezing model allowed us to monitor thermal history and investigate both vascular and tissue injury in response to the combination therapy.
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Hoffmann, Nathan E., David J. Swanlund, and John C. Bischof. "Observation of Vascular Injury After Freezing: Investigating the Response of Normal Skin and Subcutaneous AT-1 Tumor Tissue to Cryosurgery in the Dorsal Skin Flap Chamber." In ASME 1999 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1999. http://dx.doi.org/10.1115/imece1999-0579.

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Abstract Two main mechanisms have been explored in an attempt to explain injury to the cells of tissues due to freezing in vivo. The first is direct cellular injury caused by injurious osmotic changes and ice crystal formation that happens as a result of freezing (Mazur, 1984). The second is host response injury caused by the vascular damage and immunologic response in response to freezing (Gage and Baust, 1998). The amount of injury caused by freezing appears to vary with tissue type and thermal history of the freezing protocol. The hypothesis of this study was that host response injury, specifically vascular injury, causes the majority of tissue necrosis at the edge of a frozen region and therefore determines the size of the lesion seen after in vivo freezing. Many investigations have previously made a qualitative correlation between thermal history, vascular injury, and tissue necrosis (e.g. Greene. 1943 and Rabb et al., 1974). We chose the dorsal skin flap chamber (DSFC) implanted in the Copenhagen rat as the cryosurgical model for this study. This in vivo freezing model appears insensitive to the immunologic phenomenon (Hoffmann et al., 1999) and allows us to monitor thermal history and investigate both vascular and tissue injury in response to cryosurgery.
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