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Journal articles on the topic 'Rabbits as laboratory animals'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 July 2024

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1

Fallahi, Roozbeh, and Navid Dadashpour Davachi. "Evaluation of the Hairballs in the Gastrointestinal Tract and Urinary Stones in Razi Institute Laboratory Rabbits." Iranian Journal of Veterinary Medicine 17, no. 4 (2023): 375–82. http://dx.doi.org/10.32598/ijvm.17.4.1005285.

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Background: Usually, the daily self-grooming by rabbits leads to fur accumulation in the animal’s stomach. Since rabbit hair is looser than other animals and constantly licks their body, the fur can be pulled out easily. On the other hand, rabbits are susceptible to urinary stone formation. Objectives: This study was designed to investigate the presence of hairballs and urinary stones in Razi Institute Laboratory rabbits. Methods: During the 1 year, the albino Dutch laboratory rabbit colony, in research, breeding, and production of the Laboratory Animals Department of Razi Institute, including

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Iglauer, F., C. Beig, J. Dimigen, et al. "Hereditary compulsive self-mutilating behaviour in laboratory rabbits." Laboratory Animals 29, no. 4 (1995): 385–93. http://dx.doi.org/10.1258/002367795780740140.

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During the last few years an increasing number of cases of extensive automutilation has been observed in a rabbit breeding colony of Checkered crosses. Digits and pads of the front feet were traumatized. No other behavioural abnormalities or signs of disease were evident. Self-mutilation was seen both in stock, breeding and experimental animals, in rabbits kept singly in cages and in those housed in groups on the ground, in rabbits kept in different buildings and under the care of different staff members. This behavioural abnormality of Checkered crosses has also been observed in animals after

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3

Terentyeva, Z. Kh, R. Sh Taiguzin, O. A. Matveev, Kh Kh Shakhbiyev, and A. L. Kryazhev. "Diagnostic studies for common invasive and infectious pathologies of rabbits in the Orenburg region." E3S Web of Conferences 282 (2021): 03020. http://dx.doi.org/10.1051/e3sconf/202128203020.

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Rabbits, like other animal species, are susceptible to infection with invasive and infectious diseases. Both ecto- and endoparasites are registered in them, including helminths, insects on the body, acarus scabies, protozoa. Rabbits are characterized by a high degree of precocity, high fecundity and the breadth of use of the products obtained from them. As a product of rabbit breeding, first, meat is in demand as a dietary product. Part of the products from rabbits - hair, wool-molt is obtained during the life of the animal, and meat, skins, other products - after slaughter. Skins and rabbit h

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KOSTOMITSOPOULOS (Ν. ΚΩΣΤΟΜΗΤΣΟΠΟΥΛΟΣ), N., M. SERAFETINIDOU (Μ. ΣΕΡΑΦΕΤΙΝΙΔΟΥ), A. KATSAROU (Α. ΚΑΤΣΑΡΟΥ), C. VOYAZAKI (Χ. ΒΟΓΙΑΤΖΑΚΗ) та I. DONTAS (Ι. ΔΟΝΤΑ). "Εvaluation of an environmental enrichment device used for laboratory rabbits". Journal of the Hellenic Veterinary Medical Society 66, № 1 (2017): 41. http://dx.doi.org/10.12681/jhvms.15582.

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Improving the housing conditions of individually caged laboratory rabbits using environmental enrichment devices is a source of concern in the scientific community and is encouraged in the guidelines of the local and international laboratory animal associations and national regulations. In this report, we inform on the results of an investigation whose aim was to evaluate the use of a commercially available shelter as an enrichment device for six individually caged rabbits (mean body weight 2.5 Kg) during their resting period. After an acclimatization period of five days in an animal room, a c

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Koloskova, E. M., VA Ezerskiy, T. P. Trubitsyna, and N. V. Belova. "Genetically modified rabbits as bio-producers and biomodels." E3S Web of Conferences 224 (2020): 04034. http://dx.doi.org/10.1051/e3sconf/202022404034.

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Genetically modified (GM) animals are necessary to solve the global problems of humanity related to nutrition and health. Rabbits, as laboratory, domestic and farm animals, occupy a special niche in research. GM rabbits are promising as bioreactors for producing biologically active (BA) proteins with milk or blood, and are in demand in Biomedicine as biomodels of diseases. To date, many GM rabbits-biomodels, producers of recombinant proteins have been created in the world using CRISPR/Cas9 technology. All-Russian Research Institute of Animal Physiology, Biochemistry and Nutrition has experienc

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6

Dyuba, A., and V. Lyasota. "Hygienic assessment of the probiotic Bioseven influence on the natural resistance of rabbits pre-clinical researches." Naukovij vìsnik veterinarnoï medicini, no. 2 (184) (November 23, 2023): 35–47. http://dx.doi.org/10.33245/2310-4902-2023-184-2-35-47.

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Rabbit farming plays an important role in the increase of livestock products, one of the precocious branches of small animal husbandry. From a rabbit and its offspring, more than 100 kg of meat can be obtained per year. The body of rabbits, as well as other agricultural and rural animals. animals, during life is under the influence of abiotic and biotic factors that cause growth depression, changes in the morphological composition of blood, and immunological indicators. The use of biologically active drugs that increase immunological reactivity, stimulating growth, development and resistance d

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7

Izmozherova, N. V., V. V. Bazarnyi, V. M. Bakhtin, L. G. Polushina, and A. Yu Maksimova. "Analysis of the toxic effects of fluoroquinolones in laboratory rabbit models." Ural Medical Journal 22, no. 4 (2023): 61–68. http://dx.doi.org/10.52420/2071-5943-2023-22-4-61-68.

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Introduction. Fluoroquinolones are antibacterials for which the development of cardiotoxicity, hepatotoxicity, nephrotoxicity and connective tissue damage has been noted. The likely mechanism for the development of these reactions is magnesium metabolism disorder. An available method to detect fluoroquinolones toxicity in animal experiments is a blood biochemical test.The aim of the work was to identify the biochemical signs of the toxic effects of fluoroquinolones in laboratory rabbit models.Materials and methods. Twenty male rabbits randomised into three groups were included in the study: 6

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8

Izmozherova, N. V., O. S. Charkin, E. V. Markova, et al. "Echocardiography in laboratory rabbits." Ural Medical Journal 20, no. 6 (2022): 94–99. http://dx.doi.org/10.52420/2071-5943-2021-20-6-94-99.

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Introduction. Rabbits are used as convenient models for studying drug cardiotoxicity. Echocardiography is one of the most informative non-invasive methods of assessing the cardiovascular system function. In literature, there is no clearly formulated protocol for heart ultrasound examination in rabbits. Purpose was the systematization of literature data on echocardiography techniques in rabbits.Materials and methods. The sources search involved the Scientific Electronic Library eLIBRARY.RU and the National Library of Medicine information base (PubMed.gov). The search covered the 15-year period.

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Pivova, Elena Yurievna, Mikhail Evgenievich Vlasov, Timofey Aleksandrovich Sevskikh, Olga Sergeevna Povolyaeva, and Sergey Petrovich Zhivoderov. "A Study of the Susceptibility of Laboratory Animals to the Lumpy Skin Disease Virus." Life 13, no. 7 (2023): 1489. http://dx.doi.org/10.3390/life13071489.

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This article presents the results of a study on the susceptibility of laboratory animals to the lumpy skin disease virus (LSDV). Mice weighing 15–20 g, hamsters weighing 40–60 g, guinea pigs weighing 600–1200 g, and rabbits weighing 2.5–3 kg were used in this study. Nodules were observed on the skin of rabbits and hamsters at the sites of inoculation. The virus was isolated from the affected skin areas in cell culture and examined using real-time PCR, indicating its tropism for animal skin. The production of anticapripoxvirus antibodies was detected using the neutralization reaction, starting

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Matsuhisa, Fumikazu, Shuji Kitajima, Kazutoshi Nishijima, Toshiaki Akiyoshi, Masatoshi Morimoto, and Jianglin Fan. "Transgenic Rabbit Models: Now and the Future." Applied Sciences 10, no. 21 (2020): 7416. http://dx.doi.org/10.3390/app10217416.

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Transgenic rabbits have contributed to the progress of biomedical science as human disease models because of their unique features, such as the lipid metabolism system similar to humans and medium body size that facilitates handling and experimental manipulation. In fact, many useful transgenic rabbits have been generated and used in research fields such as lipid metabolism and atherosclerosis, cardiac failure, immunology, and oncogenesis. However, there have been long-term problems, namely that the transgenic efficiency when using pronuclear microinjection is low compared with transgenic mice

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11

Miranda, Alice, José M. Pêgo, and Jorge Correia-Pinto. "Animal facility videoendoscopic intubation station: tips and tricks from mice to rabbits." Laboratory Animals 51, no. 2 (2016): 204–7. http://dx.doi.org/10.1177/0023677216652342.

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Endotracheal intubation of laboratory animals is a common procedure shared by several research fields for different purposes, such as mechanical ventilation of anaesthetized animals, instillation of cytotoxic nanoparticles, infectious agents or tumour cells for induction of disease models, and even for diagnostic and therapeutic purposes. These different research purposes, achieved in different animal models, require technical expertise and equipment that suits every research need from animal facilities. In this short report we propose a videoendoscopic intubation station that could be shared

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12

Semakova, A. P., V. G. Germanchuk, V. V. Rogozhin, et al. "Anesthesia of laboratory animals in manufacturing of diagnostic and preventive biomedicines." Russian Journal of Infection and Immunity 10, no. 1 (2020): 83–89. http://dx.doi.org/10.15789/2220-7619-aol-810.

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Preparations such as XilaVet, Zoletil 100 as well as Aeranne (Isoflurane) are successfully applied for animal anesthesia in veterinary practice. We assessed a possibility of using parenteral narcosis with Zoletil 100 in combination with muscle relaxant Xila for producer-rabbits involved in manufacturing of natural rabbit serum subsequently deployed for production of diagnostic serum and immunoglobulin preparations. Administration of preparations into auricular vein is easy to do, while animals are sedated immediately allowing for safe fixation on restraining table and causing no additional str

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13

Fisher, Penny, Samantha Brown, and Jane Arrow. "Pindone residues in rabbit tissues: implications for secondary hazard and risk to non-target wildlife." Wildlife Research 42, no. 4 (2015): 362. http://dx.doi.org/10.1071/wr15019.

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Context Pindone is used to control rabbits in Australia and New Zealand, but the secondary non-target risks presented by pindone-poisoned rabbits are poorly known. Aims We aimed to generate new data on residual concentrations of pindone in poisoned rabbits for use in a review of the secondary poisoning risks posed to non-target animals in New Zealand. Methods Laboratory rabbits were offered pellet bait containing 0.25 g kg–1 pindone in three trials to simulate a range of bait uptake scenarios: single exposure and low or high chronic exposure. Residual pindone concentrations measured in body ti

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14

Shchelkunov, S. N., A. A. Sergeev, S. N. Yakubitskyi, K. A. Titova, and S. A. Pyankov. "Assessing immunogenicity and protectiveness of the vaccinia virus LIVP-GFP in three laboratory animal models." Russian Journal of Infection and Immunity 11, no. 6 (2021): 1167–72. http://dx.doi.org/10.15789/2220-7619-aia-1668.

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Smallpox eradication and lack of adequate animal model for smallpox infection underlies a necessity to assess immunogenic and protective properties of genetic engineering-created live attenuated smallpox vaccines in several animal models of orthopoxviral infections. Here we compared immunogenic and protective properties of the recombinant vaccinia virus (VACV) LIVP-GFP intradermally (i.d.) inoculated to mice, guinea pigs and rabbits. LIVP-GFP immunization in all animal species was applied at dose of 2 × 104 or 2 × 106 PFU. Control animals were injected with saline. Blood sampling was performed

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15

Evstifeev, V. V., F. M. Khusainov, S. I. Yakovlev, G. I. Khusainova, I. R. Akbashev, and D. D. Morozova. "ASSESSMENT OF THE EFFECTIVENESS OF A UNIVERSAL VACCINE AGAINST AGRICULTURAL ANIMAL CHLAMIDIOSIS ON RABBITS." Scientific Notes Kazan Bauman State Academy of Veterinary Medicine 245, no. 1 (2021): 41–46. http://dx.doi.org/10.31588/2413-4201-1883-245-1-41-46.

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The article presents data on laboratory tests of a universal vaccine against chlamydia of farm animals for sterility, safety, antigenic activity and immunogenicity. The sterility of the new vaccine preparation was evaluated on nutrient media (MPA, MPB, MPPB and Saburo), the vaccine was harmless according to the results of bioassays on laboratory white mice and guinea pigs. The vaccine was found to be sterile and harmless to laboratory animals. Evaluation of antigenic activity was car-ried out on rabbits, the study lasted 195 days, the results were taken into account on the basis of data obtain

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16

Meanger, J. D., and R. B. Marshall. "Campylobacter jejuni infection within a laboratory animal production unit." Laboratory Animals 23, no. 2 (1989): 126–32. http://dx.doi.org/10.1258/002367789780863637.

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A conventional laboratory animal production unit in which rats, mice, guineapigs and rabbits were bred in one building and cats maintained in a separate, but adjacent area was examined for the presence of intestinal thermophilic Campylobacter spp. Campylobacter jejuni was recovered from 18·84% of 552 animals. The infection rate was highest amongst the cats (51·7%), with rats being the second most commonly infected (23·2%), whereas only 7·7% of guineapigs and a single rabbit (1%) were positive. Campylobacter-like organisms were cultured from 10% of the mice, but these bacteria failed to grow on

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Verwer, Cynthia M., Arno van der Ark, Geert van Amerongen, Ruud van den Bos, and Coenraad F. M. Hendriksen. "Reducing variation in a rabbit vaccine safety study with particular emphasis on housing conditions and handling." Laboratory Animals 43, no. 2 (2009): 155–64. http://dx.doi.org/10.1258/la.2008.007134.

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This paper describes the results of a study of the effects of modified housing conditions, conditioning and habituation on humans using a rabbit model for monitoring whole-cell pertussis vaccine (pWCV)-induced adverse effects. The study has been performed with reference to previous vaccine safety studies of pWCV in rabbits in which results were difficult to interpret due to the large variation in experimental outcome, especially in the key parameter deep-body temperature ( Tb). Certain stressful laboratory conditions, as well as procedures involving humans, e.g. blood sampling, inoculation and

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Jezierski, T., P. Mekking, and P. R. Wiepkema. "Handling and diet-induced atherosclerosis in rabbits." Laboratory Animals 27, no. 3 (1993): 235–39. http://dx.doi.org/10.1258/002367793780745390.

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Atherosclerosis was induced in rabbits by feeding them a 2% cholesterol diet (CHOL) during a 5-week period. Twelve rabbits were fed with increasing amounts of CHOL food until the ad libitum level was reached, whereas in 24 other rabbits the food was limited to the amount eaten by the lowest consumer of the group to reduce individual variability in total amount of food consumed. Twice a day, half of the rabbits were handled carefully, the other half had normal laboratory practice contact with their caretaker. Feed intake and amount of atherosclerosis were determined for all experimental animals

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KATSAROU (Α. ΚΑΤΣΑΡΟΥ), A., A. TSIRONI (Α. ΤΣΙΡΩΝΗ), M. SERAFETINIDOU (Μ. ΣΕΡΑΦΕΤΙΝΙΔΟΥ), C. VOYAZAKI (Χ. ΒΟΓΙΑΤΖΑΚΗ), V. BAUMANS, and N. KOSTOMITSOPOULOS (Ν. ΚΩΣΤΟΜΙΤΣΟΠΟΥΛΟΣ). "Age - related behaviour on individually caged rabbits." Journal of the Hellenic Veterinary Medical Society 62, no. 1 (2017): 21. http://dx.doi.org/10.12681/jhvms.15036.

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Housing conditions and environmental enrichment of individually caged laboratory rabbits is of great importance for the welfare of the animals and the quality of the experimental results. In order to improve the design of existing environmental enrichment programs for laboratory rabbits, considerable knowledge of the behavioural needs of this species is necessary. Taking this into consideration, the aim of this study was to monitor and analyze the behaviour of juvenile and young adult rabbits in order to establish whether there are any age-dependent differences in grooming, rearing, sniffing,

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Sümer, Aziz, Sebahattin Çelik, Talar Vartanoğlu Aktokmakyan, et al. "A new approach in bariatric operations: bridged mini gastric by-pass. Is rabbit model suitable for an experimental study?" Turkish Journal of Surgery 37, no. 3 (2021): 294–98. http://dx.doi.org/10.47717/turkjsurg.2021.4874.

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Objective: Obesity is a global health epidemic with considerable co-morbidities. The increasing demand for bariatric surgery has led to the emergence of new techniques. We modified previously described Mini Gastric By-pass(MGB) technique via leaving a bridge at the most cranial 2 cm of the fundus of the human stomach to the follow-up and treatment of the remnant stomach and duodenum. We would like to entitle this new technique as Bridged MGB and aimed to apply on rabbits as an experimental study. Material and Methods: The study was performed in the experimental animal laboratory of university

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Sawin, Paul D., Curtis A. Dickman, Neil R. Crawford, M. Stephen Melton, William D. Bichard, and Volker K. H. Sonntag. "The effects of dexamethasone on bone fusion in an experimental model of posterolateral lumbar spinal arthrodesis." Journal of Neurosurgery: Spine 94, no. 1 (2001): 76–81. http://dx.doi.org/10.3171/spi.2001.94.1.0076.

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Object. The use of corticosteroid agents during the healing phase after spinal arthrodesis remains controversial. Although anecdotal opinion suggests that corticosteroids may inhibit bone fusion, such an effect has not been substantiated in clinical trials or laboratory investigations. This study was undertaken to delineate the effect of exogenous corticosteroid administration on bone graft incorporation in an experimental model of posterolateral lumbar fusion. Methods. An established, well-validated model of lumbar intertransverse process spinal fusion in the rabbit was used. Twenty-four adul

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Kobeniak, N. N. "MORPHOLOGY OF THE CAECUM IN LABORATORY ANIMALS IN HEALTH: SPECIES COMPARISON." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 20, no. 2 (2020): 134–37. http://dx.doi.org/10.31718/2077-1096.20.2.134.

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In recent decades, the prevalence of gastrointestinal diseases has increased thus posing the immediate, both therapeutic and surgical treatment. It brings forth a problem of searching new and improving existing approaches and techniques for correcting the above-mentioned diseases. Preclinical studies in this area are conducted exclusively on laboratory animals and peculiarities of the morphological features of their organs are of great importance when comparing with the human morphology. The methodology used in the study included histological, morphometric and statistical techniques; biopsy sa

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Pokhodnya, G. S., S. N. Kotlyarova, Y. P. Breslavets, I. S. Demidenko, and T. V. Kreneva. "Directed work on breeding of high-blooded rabbit litters in the rabbit breeding laboratory of Belgorod GAU." BIO Web of Conferences 108 (2024): 01008. http://dx.doi.org/10.1051/bioconf/202410801008.

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The rabbit is one of the most common types of laboratory animals used in a number of experimental studies in general biology, medicine and veterinary medicine. And today, the most actively discussed strategy is the policy of import substitution as a factor in ensuring the growth of domestic agribusiness, and of course rabbit breeding is the most promising and rapidly developing industry. Therefore, we believe that the creation of crossbred rabbits of domestic selection that are not inferior in their characteristics to their European counterparts is an extremely urgent task, which served as the

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Izmozherova, N. V., V. M. Bakhtin, A. A. Yakovleva, M. A. Bashindzhagyan, E. A. Makarov, and K. A. Kabanova. "Effect of fluoroquinolones on the cardiovascular system of laboratory rabbits." Ural Medical Journal 22, no. 1 (2023): 72–77. http://dx.doi.org/10.52420/2071-5943-2023-22-1-72-77.

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Introduction. The use of fluoroquinolones is associated with prolongation of the QT interval on the cardiogram and increased risk of ventricular tachycardia. To study the mechanism of the cardiotoxic effect of fluoroquinolones and to develop methods of its prevention it is necessary to create models on laboratory animals. The aim of the work was to analyze the effect of fluoroquinolones on the electrocardiographic parameters of laboratory rabbits. Materials and methods. 20 rabbits were divided into 3 groups: 6 animals were control, 7 animals received ciprofloxacin 150 mg/kg for 14 days orally,

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Dalbey, W., S. Rodriguez, K. Wilkins, and C. Cope. "Reducing the Number of Rabbits in Eye and Skin Irritancy Tests." Journal of the American College of Toxicology 12, no. 4 (1993): 347–57. http://dx.doi.org/10.1177/109158189301200405.

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Reduction in the number of rabbits used for acute testing of irritation in the eye and skin is a worthwhile goal, and some recent publications have supported such reduction from six to three animals. In anticipation of making such reductions in our laboratory, data from 185 eye and 179 skin irritation tests performed in-house were evaluated within the framework of several schemes of classification. Mean scores for irritation in all possible two, three, four, and five-rabbit subsets were compared to scores with all six rabbits. Parameters included mean weighted Draize scores (eye) and Occupatio

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Qiao, Jiao-Jiao, Shan-Ni Wang, Jing-Jing Li, et al. "Effectiveness of treatment of bedding and feces of laboratory animal with ozone." PLOS ONE 17, no. 4 (2022): e0266223. http://dx.doi.org/10.1371/journal.pone.0266223.

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Background The incineration and burying of the soiled bedding of laboratory animals, as well as using detergents to treat their feces, is hazardous to the environment. This highlights the need for an alternative, environmentally friendly solution for the treatment of the waste of laboratory animal facilities. This study aims to evaluate the efficacy of ozone disinfection of the soiled bedding and feces of laboratory animals. Methods Two grams of soiled beddings were randomly sampled from the cages of mice and rats. These samples were mixed in a beaker with 40ml saline. Ozone was piped into the

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Baker, David G. "Natural Pathogens of Laboratory Mice, Rats, and Rabbits and Their Effects on Research." Clinical Microbiology Reviews 11, no. 2 (1998): 231–66. http://dx.doi.org/10.1128/cmr.11.2.231.

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SUMMARY Laboratory mice, rats, and rabbits may harbor a variety of viral, bacterial, parasitic, and fungal agents. Frequently, these organisms cause no overt signs of disease. However, many of the natural pathogens of these laboratory animals may alter host physiology, rendering the host unsuitable for many experimental uses. While the number and prevalence of these pathogens have declined considerably, many still turn up in laboratory animals and represent unwanted variables in research. Investigators using mice, rats, and rabbits in biomedical experimentation should be aware of the profound

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Roychoudhury, S., J. Bulla, J. Čurlej, and P. Chrenek. "Hypodiploidy as a prominent attributor to chromosomal aneuploidy in transgenic rabbit embryos." Czech Journal of Animal Science 53, No. 9 (2008): 388–97. http://dx.doi.org/10.17221/336-cjas.

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Transgenic animals play a vital role in basic research, agriculture and pharmaceutical industries. Rabbits have the advantage of other large laboratory species in that they have a short gestation period and yield large numbers of embryos. Production of transgenic rabbits has been directed towards using the rabbit as a model for large domestic animals or as a basic biological model for studying the mammalian gene regulation. In connection with their use, developmental and health disorders have also been reported in genetically modified animals. Random integration of a transgene can disrupt the

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Andronowski, Janna M., Adam J. Schuller, Mary E. Cole, Abigail R. LaMarca, Reed A. Davis, and Gina R. Tubo. "Rabbits (Oryctolagus cuniculus) as a Model System for Longitudinal Experimental Opioid Treatments: Implications for Orthopedic and Biomedical Research." Osteology 1, no. 4 (2021): 225–37. http://dx.doi.org/10.3390/osteology1040021.

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Due to the high prevalence of opioid prescription following orthopedic procedures, there is a growing need to establish an animal model system to evaluate the effects of opioids on bone remodeling. Rabbits have been employed as model organisms in orthopedic research as they exhibit well-defined cortical bone remodeling similar to humans. Existing research in rabbits has been limited to modes of opioid administration that are short-acting and require repeated application. Here, we present data from a proof-of-principle longitudinal study employing two opioid analgesic administration routes (sub

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Smith, William. "Responses of laboratory animals to some injectable anaesthetics." Laboratory Animals 27, no. 1 (1993): 30–39. http://dx.doi.org/10.1258/002367793781082377.

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Xylazine, ketamine, methohexitone and alphadalone/alphaxalone, were administered intraperitoneally, intramuscularly or intravenously to mice, rats, guineapigs and rabbits. Times for disappearance and reappearance of reflexes were recorded, and duration of loss of reflex. Delivering a predetermined dose gave a varying individual response, ranging from inadequate anaesthesia to death. Using reflexes to assess depth of anaesthesia was of limited value. Reflex movements to noxious stimuli generally persisted even at dose rates that caused prolonged recovery times and death. Conversely, in rats the

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Bayne, Kathryn A. L. "Environmental Enrichment of Nonhuman Primates, Dogs and Rabbits Used in Toxicology Studies." Toxicologic Pathology 31, no. 1_suppl (2003): 132–37. http://dx.doi.org/10.1080/01926230390175020.

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The increasing emphasis on the provision of environmental enrichment to laboratory animals, vis-à-vis the USDA Animal Welfare Regulations, the Guide for the Care and Use of Laboratory Animals (NRC 1996), and a potential forthcoming policy from the USDA on the subject, can be difficult to accommodate in a toxicology research environment. A summary will be provided of current requirements and recommendations. Then, strategies for meeting regulatory requirements will be described for non-rodent animals used in toxicology research. These strategies will address methods of both social enrichment, s

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Razook, Basil R. F., Mariam Hamdi Abdulkareem, and Ansam Khalid Mohammed. "Hematological effects for rabbits immunized by Corynebacterium pseudotuberculosis sonicated antigen." Advancements in Life Sciences 11, no. 2 (2024): 375. http://dx.doi.org/10.62940/als.v11i2.2360.

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Background: Analyzing Hematological parameters is usually in use to monitor various circumstances such as infection, inflammation and anemia. For that we studied blood parameters which are in touch with immunized laboratory animals (rabbits) after immunizing these animals with Corynebacterium pseudotuberculosis then used an adjuvant of Pseudomonas aeruginosa to stimulate the immune response cells after 2 to 3 weeks of immunization. Different concentrations were used to examine the effect on the animals’ blood parameters changing.Methods: Corynebacterium pseudotuberculosis bacterium was used at

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Ivanov, N. P., N. N. Egorova, S. N. Sarimbekova, V. Yu Sushi, and A. K. Ilimbayeva. "BIOLOGICAL PROPERTIES OF FUSOBACTERIUM NECROPHORUM ISOLATED FROM INFECTED CATTLE TISSUES IN ALMATY REGION." REPORTS 5, no. 333 (2020): 63–72. http://dx.doi.org/10.32014/2020.2518-1483.120.

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Necrobacteriosis (necrobacteriosis) is established as an infectious disease characterized by purulent-necrotic lesions of tissues mainly of the lower parts of the extremities, especially in the area of the corolla, and in some cases in the oral cavity, on the udder, in the genitals, liver, lungs and other tissues and organs. Many animal species are affected by necrobacteriosis. The most susceptible and sensitive to Fusobacterium necrophorum are reindeer, cattle and small ruminants, pigs, and rabbits. A constant carrier of the causative agent of necrobacteriosis in the rumen and intestines of r

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Korytov, Oleg, Sergey Ivanov, Luiza Korytova, et al. "Experimental therapy for rabbits with radiation cystitis." Problems in oncology 67, no. 1 (2021): 150–56. http://dx.doi.org/10.37469/0507-3758-2021-67-1-150-156.

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Using a new model of the induction of radiation cystitis (RC) in rabbits, the treatment effectiveness of animals with intravesical administration of a biodegradable drug - a gel containing salts of alginic and hyaluronic acids, as well as dioxidine and lidocaine (AHDL) was assessed. The work was performed on female rabbits of the “Chinchilla” breed. Fractional irradiation of the rabbit urinary bladder was carried out by a linear photon accelerator: a single dose per fraction was 6 Gy administered daily for 5 days to a total focal dose of 30 Gy. As a result of irradiation of the bladder, the an

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Beesley, Julian E., David Hassall, Eileen A. Jessup, et al. "Early Cellular Events in the Development of Atherosclerotic Lesions in a Model of Accelerated Atherosclerosis in the Rabbit." Proceedings, annual meeting, Electron Microscopy Society of America 48, no. 3 (1990): 272–73. http://dx.doi.org/10.1017/s0424820100158911.

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We have generated several of the characteristic features of human atherosclerotic lesions in the rabbit with in 14 days by the placement of a soft, silastic collar around the carotid artery. Preliminary microscopical studies show that the lesion in the region of the collar consists of proliferating smooth muscle cells, foam cells in animals maintained on a high cholesterol diet and that the endothelial cells appear intact. The histology of the contralateral arteries was unaffected by the placement of the collar. This report describes our observations of the early cellular changes in the collar

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Tokarz-Deptuła, B., P. Niedźwiedzka-Rystwej, B. Hukowska-Szematowicz, M. Adamiak, A. Trzeciak-Ryczek, and W. Deptuła. "B-cell and T-cell values in peripheral blood in Polish mixed-breed rabbits with addition of blood of meet breeds." Polish Journal of Veterinary Sciences 17, no. 3 (2014): 421–26. http://dx.doi.org/10.2478/pjvs-2014-0060.

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Abstract In Poland, rabbit is a highly valued animal, due to dietetic and flavour values of its meat, but above all, rabbits tend to be commonly used laboratory animals. The aim of the study was developing standards for counts of B-cells with CD19+ receptor, T-cells with CD5+ receptor, and their subpopulations, namely T-cells with CD4+, CD8+ and CD25+ receptor in the peripheral blood of mixed-breed Polish rabbits with addition of blood of meet breeds, including the assessment of the impact of four seasons of the year and animal sex on the values of the immunological parameters determined. The

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Babar, Abdul Mannan, and Abdul Hannan Nagi. "KELOID." Professional Medical Journal 23, no. 09 (2016): 1157–62. http://dx.doi.org/10.29309/tpmj/2016.23.09.2479.

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Keloids and hypertrophic scars are basically an overabundance of fibrosis in cutaneous healing process. Unfortunately, keloids are only found in human beings. So far no successful animal model of keloid has been reported. Objectives: To produce an animal model of keloid. Main Outcome Measure: Animal model of keloid. Design: Prospective quasiexperimental trial. Setting: Department of Pathology and Experimental Research Laboratory, University of Health Sciences, Lahore, Pakistan. Duration: One year. Sample Size: Twelve albino animals i.e. three mice, three rats, three Guinea pigs, and three rabb

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Tkachuk, О. М., and T. V. Tkachuk. "Rabbits as a biological model for experimental studies (review of literature)." Ukrainian Journal of Modern Toxicological Aspects 91, no. 2 (2021): 104–8. http://dx.doi.org/10.33273/2663-4570-2021-91-2-104-108.

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The Aim of the Research. To analyse and summarize the data of modern literature on the use of rabbits for laboratory experimental studies and substantiate the prospects for their further use. Materials and Methods. The analytical methods such as collection of scientific information on the problem, analysis of literature data from PubMed libraries as well as scientific generalization of the results obtained were used in the work. Results and Conclusions. The principles of the prospects for the further use of rabbits for laboratory experimental studies have been substantiated. Thanks to certain

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Scháňková, Š., I. Langrová, I. Jankovská, J. Vadlejch, Z. Čadková, and D. Křivská. "Screening of Model Animals for Experimental Infection with Equine Cyathostomes." Scientia Agriculturae Bohemica 49, no. 1 (2018): 17–20. http://dx.doi.org/10.2478/sab-2018-0003.

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Abstract Various laboratory animals – mice (Mus musculus) of six strains, rabbits (Oryctolagus cuniculus), guinea pigs (Cavia porcellus), rats (Rattus norvegicus), and Mongolian gerbils (Meriones unguiculatus) were experimentally infected with larvae of small strongyles (Cyathostominae), obtained from horse faeces and cultured to the infective larval stage L3. The attempt to transfer cyathostome larvae was aimed at developing a model for the investigation of different aspects of the life cycle and biology of these nematodes in the laboratory. Some animals were immunized (hydrocortisone) for th

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Mooney, Mark P., H. Losken Wolfgang, Michael I. Siegel, et al. "Development of a Strain of Rabbits with Congenital Simple Nonsyndromic Coronal Suture Synostosis Part I: Breeding Demographics, Inheritance Pattern, and Craniofacial Anomalies." Cleft Palate-Craniofacial Journal 31, no. 1 (1994): 1–7. http://dx.doi.org/10.1597/1545-1569_1994_031_0001_doasor_2.3.co_2.

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The lack of an animal model of congenital coronal suture (CS) synostosis has prompted the widespread use of an experimental rabbit model using adhesive Immobilization of the CS. Such postnatal models have helped make significant scientific contributions but may still not fully represent all aspects of the human congenital condition. In the March 1993 issue of The Cleft Palate-Craniofacial Journal we reported a female rabbit born in our laboratory with complete bilateral CS synostosis. This follow-up study presents our attempts to breed this animal and establish a strain of cranlosynostotic rab

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Сидельникова, A. Sidelnikova, Начева, L. Nacheva, Боборыкин, and M. Boborykin. "Clinical aspects of acute opisthorchiasis in rabbits in the experiment." Russian Journal of Parasitology 3, no. 3 (2016): 374–79. http://dx.doi.org/10.12737/21661.

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Objective of research: to investigate the clinical features of acute opisthorchiasis in rabbits. Materials and methods: Clinical evidence of acute opisthorchiasis in rabbits, laboratory blood tests.  Results and discussion: Skin lesions in the form of cracks and ulcers of various sizes in the neck, thoracic back and croup, mostly localized along the spine, were clinically identified in acute opisthorchiasis of rabbits. Weight loss within the first month was up to 300 — 500 grams. Laboratory tests showed that one month later, the level of blood glucose in the infected animals was 3

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Gutyj, B., O. Boyko, and L. Korchan. "Epizootological monitoring of rabbit parasitoses on the territory of Ukraine." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 25, no. 109 (2023): 3–7. http://dx.doi.org/10.32718/nvlvet10901.

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One of the conditions for successfully managing rabbit breeding is ensuring the epizootological well-being of farms concerning invasive animal diseases. Helminthiases, protozooses, and acaroses cause significant economic damage to the industry due to a decrease in the biological value of rabbit meat and skins, a delay in growth, development, and a decrease in the growth of young animals, as well as their death. Carrying out epizootic monitoring and assessment of the epizootic situation in different regions of Ukraine is one of the main preventive measures, which, based on the results of the st

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Maurice, John P., Ashish S. Shah, Alan P. Kypson та ін. "Molecular β-adrenergic signaling abnormalities in failing rabbit hearts after infarction". American Journal of Physiology-Heart and Circulatory Physiology 276, № 6 (1999): H1853—H1860. http://dx.doi.org/10.1152/ajpheart.1999.276.6.h1853.

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We studied alterations in the β-adrenergic receptor (β-AR) system of rabbit hearts during the development of heart failure (HF) after myocardial infarction (MI) to determine whether the molecular β-AR abnormalities associated with human HF exist in this animal model. Rabbit HF was established 3 wk after left circumflex coronary artery (LCX) ligation by in vivo physiological measurements, and molecular β-AR signaling was examined in tissue and cultured ventricular myocytes. We found that there was a significant global reduction in β-AR density by ∼50% in both ventricles of MI animals compared w

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Rashid, Sulthan Al, Syed Ziaur Rahman, and Saif Khan. "Comparative study for safety and efficacy of a novel folic acid formulation gel with 0.1% triamcinolone acetonide paste in experimentally induced oral ulcer." Indian Journal of Physiology and Pharmacology 65 (June 2, 2021): 39–44. http://dx.doi.org/10.25259/ijpp_11_2021.

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Objectives: The objective of the present study was to evaluate the efficacy and safety of 0.1% novel folic acid gel in blunt dental instrument-induced oral ulcer in animal models (both rats and rabbits). Materials and Methods: The study was conducted in the Experimental Laboratory, Department of Pharmacology, Jawaharlal Nehru Medical College, Aligarh Muslim University. Animals were randomly divided into three interventional groups, namely Group 1 (folic acid gel), Group 2 (triamcinolone oromucosal paste) and Group 3 (control). We created a linear oral ulcer of 5 mm with the blunt dental instru

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Sushchikh, V., A. Musayeva, and N. Yegorova. "CATTLE NECROBACTERIOSIS IN THE LIVESTOCK FACILITIES OF THE ALMATY REGION." National Association of Scientists 2, no. 74 (2021): 13–21. http://dx.doi.org/10.31618/nas.2413-5291.2021.2.74.523.

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Necrobacteriosis affects many species of animals. The most susceptible and sensitive to Fusobacterium necrophorum are reindeer, cattle and small cattle, pigs, and rabbits. A constant carriership of the causative agent of necrobacteriosis in the rumen and intestines of ruminants has been established, causative agent is found in food particles during chewing, as well as in feces. The causative agent of necrobacteriosis is widespread in the environment (livestock buildings, walking yards, manure, soil, pastures, stagnant reservoirs, etc.). Infestation of animals occurs when the pathogen enters th

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Amanda, Fadila Zikri, Poedji Hastutiek, Emy Koestanti Sabdoningrum, Nunuk Dyah Retno Lastuti, Endang Suprihati, and Hana Eliyani. "The Conformity of Diagnostic Test Between Burrow Ink Test Method With Skin Scrapping Method of Scabies in Rabbit (Lepus domesticus)." Journal of Parasite Science 2, no. 1 (2019): 29. http://dx.doi.org/10.20473/jops.v2i1.16381.

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This study intend to know the conformity of diagnostic test between burrow ink test method with skin scrapping method of scabies in rabbit. Scabies caused by Sarcoptes scabiei which has a predilection in stratum corneum and lucidum. Clinical symptoms was characterized by papula or crusting of the skin. This study presents a laboratory explorative research with cross sectional approach. Samples used 20 rabbits that infested scabies naturally. Data obtained by performing diagnostic burrow ink test method and skin scrapping in rabbits which are infested scabies naturally. KAPPA test used as data

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Galiakbarova, Alsu A., and Mikhail K. Pirozhkov. "Relationship between immunogenic and antigenic activity of the vaccine against colibacteriosis of animals." RUDN Journal of Agronomy and Animal Industries 15, no. 2 (2020): 200–209. http://dx.doi.org/10.22363/2312-797x-2020-15-2-200-209.

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Studies of such quality indicators as immunogenic and antigenic activity of the vaccine against colibacteriosis of animals have been carried out in experiments with laboratory animals. Immunogenic activity was determined by vaccination of white mice with different doses of the vaccine, followed by infection with virulent strains of Escherichia , producers of adhesive antigens, and determination of ID The antigenic activity of the vaccine was studied in experiment on rabbits by determining the level of antibodies to adhesive antigens in agglutination reaction in blood serum of vaccinated animal

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Goralskyi, L. P., N. M. Glukhova, I. M. Sokulskyi, and N. V. Demus. "Features of the macro and microscopic structure of the lungs of a mature rabbit – Oryctolagus cuniculus L. 1758." Ukrainian Journal of Veterinary and Agricultural Sciences 4, no. 1 (2021): 39–44. http://dx.doi.org/10.32718/ujvas4-1.08.

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The macro- and microscopic structure of the lungs of mature rabbits – Oryctolagus cuniculus L., 1758 – European rabbit was studied. This work was performed using comprehensive research methods: anatomical, organometric, histological and histometric. The research was carried out in the conditions of the laboratory of pathomorphology in the Department of Anatomy and Histology. The scientific work was performed on the subject of research work of the Department of Anatomy and Histology of Polissya National University on the theme: “Development, morphology and histochemistry of animal organs in nor

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Held, S. D. E., R. J. Turner, and R. J. Wooton. "Choices of laboratory rabbits for individual or group-housing." Applied Animal Behaviour Science 46, no. 1-2 (1995): 81–91. http://dx.doi.org/10.1016/0168-1591(95)00632-x.

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Salim, F. D., K. M. Ibrahim, and W. H. Yousif. "THE EFFECTIVENESS OF EXTRACT THE SEED OF POMEGRANATE IN HEALING THE WOUND INDUCED INRABBITS SKIN." IRAQI JOURNAL OF AGRICULTURAL SCIENCES 53, no. 2 (2022): 265–71. http://dx.doi.org/10.36103/ijas.v53i2.1533.

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The present study was conducted to evaluate wound induced in rabbit skin by using alcohols and aqueous extracts of pomegranate seeds. Total flavonoids concentration were estimated using high performance liquid chromatography (HPLC). The highest flavonoids concentration were recorded in ethanol extract. Acute inflammation was induced in laboratory animals (rabbits) by injecting 0.1mL of 2.5% formalin inside the wound incision. Aqueous and ethanol extracts of pomegranate seeds an anti-inflammatory and healing effect compared with the Vaseline on rabbit skin. A histopathological study was conduct

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