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Journal articles on the topic 'RAbcb7'

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Published: 4 June 2021

Last updated: 4 February 2022

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1

Gomi, Hiroshi, Kenichi Mori, Shigeyoshi Itohara, and Tetsuro Izumi. "Rab27b Is Expressed in a Wide Range of Exocytic Cells and Involved in the Delivery of Secretory Granules Near the Plasma Membrane." Molecular Biology of the Cell 18, no. 11 (2007): 4377–86. http://dx.doi.org/10.1091/mbc.e07-05-0409.

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Rab proteins regulate multiple, complex processes of membrane traffic. Among these proteins, Rab27a has been shown to function specifically in regulated exocytic pathways. However, the roles of Rab27b, another Rab27 subfamily member, have not been well characterized. We disrupted the Rab27b gene in mice. The targeting vector was designed to insert LacZ downstream of the initiation codon of the Rab27b gene so that the authentic promoter should drive this reporter gene. A comprehensive analysis of Rab27b expression using this mouse strain indicated that it is widely expressed not only in canonic

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2

Abenza, Juan F., Antonio Galindo, Areti Pantazopoulou, Concha Gil, Vivian de los Ríos, and Miguel A. Peñalva. "Aspergillus RabBRab5 Integrates Acquisition of Degradative Identity with the Long Distance Movement of Early Endosomes." Molecular Biology of the Cell 21, no. 15 (2010): 2756–69. http://dx.doi.org/10.1091/mbc.e10-02-0119.

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Aspergillus nidulans early endosomes display characteristic long-distance bidirectional motility. Simultaneous dual-channel acquisition showed that the two Rab5 paralogues RabB and RabA colocalize in these early endosomes and also in larger, immotile mature endosomes. However, RabB-GTP is the sole recruiter to endosomes of Vps34 PI3K (phosphatidylinositol-3-kinase) and the phosphatidylinositol-3-phosphate [PI(3)P] effector AnVps19 and rabBΔ, leading to thermosensitivity prevents multivesicular body sorting of endocytic cargo. Thus, RabB is the sole mediator of degradative endosomal identity. I

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3

Tiwari, Sanjay, Joseph E. Italiano, Duarte C. Barral, et al. "A role for Rab27b in NF-E2-dependent pathways of platelet formation." Blood 102, no. 12 (2003): 3970–79. http://dx.doi.org/10.1182/blood-2003-03-0977.

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Abstract Megakaryocytes release platelets by reorganizing the cytoplasm into proplatelet extensions. Fundamental to this process is the need to coordinate transport of products and organelles in the appropriate abundance to nascent platelets. The importance of the Rab family of small GTPases (guanosine 5′-triphosphatases) in platelet biogenesis is revealed in gunmetal (gm/gm) mice, which show deficient Rab isoprenylation and macrothrombocytopenia with few granules and abnormal megakaryocyte morphology. Although some Rab proteins are implicated in vesicle and organelle transport along microtubu

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4

Meng, Zhen, Maria C. Edman, Pang-Yu Hsueh, et al. "Imbalanced Rab3D versus Rab27 increases cathepsin S secretion from lacrimal acini in a mouse model of Sjögren's Syndrome." American Journal of Physiology-Cell Physiology 310, no. 11 (2016): C942—C954. http://dx.doi.org/10.1152/ajpcell.00275.2015.

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The mechanism responsible for the altered spectrum of tear proteins secreted by lacrimal gland acinar cells (LGAC) in patients with Sjögren's Syndrome (SS) remains unknown. We have previously identified increased cathepsin S (CTSS) activity as a unique characteristic of tears of patients with SS. Here, we investigated the role of Rab3D, Rab27a, and Rab27b proteins in the enhanced release of CTSS from LGAC. Similar to patients with SS and to the male nonobese diabetic (NOD) mouse model of SS, CTSS activity was elevated in tears of mice lacking Rab3D. Findings of lower gene expression and altere

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5

Chiang, Lilian, Julie Ngo, Joel E. Schechter, et al. "Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland." American Journal of Physiology-Cell Physiology 301, no. 2 (2011): C507—C521. http://dx.doi.org/10.1152/ajpcell.00355.2010.

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Tear proteins are supplied by the regulated fusion of secretory vesicles at the apical surface of lacrimal gland acinar cells, utilizing trafficking mechanisms largely yet uncharacterized. We investigated the role of Rab27b in the terminal release of these secretory vesicles. Confocal fluorescence microscopy analysis of primary cultured rabbit lacrimal gland acinar cells revealed that Rab27b was enriched on the membrane of large subapical vesicles that were significantly colocalized with Rab3D and Myosin 5C. Stimulation of cultured acinar cells with the secretagogue carbachol resulted in apica

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Maldonado, Jose Alberto, Minsoo Kim, Prasamsa Pandey, et al. "Use of a rapid access multidisciplinary bone metastases clinic to decrease financial toxicity for patients undergoing single-fraction palliative radiation." Journal of Clinical Oncology 38, no. 29_suppl (2020): 24. http://dx.doi.org/10.1200/jco.2020.38.29_suppl.24.

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24 Background: A rapid access bone metastases clinic (RABC) was instituted at MD Anderson Cancer Center (MDACC) to allow outpatient consult, simulation and radiation treatment (RT) initiation in < 6 hours for patients with painful bone metastases. Patients underwent multidisciplinary evaluation with orthopedics and radiation oncology. One aspect of financial toxicity is distress due to out-of-pocket (OOP) cost associated with a treatment. We hypothesized the RABC would decrease financial toxicity for MDACC patients over traditional RT. Methods: RABC patients surveyed between April 2018 and

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7

Bolasco, Giulia, Dhani C. Tracey-White, Tanya Tolmachova, et al. "Loss of Rab27 function results in abnormal lung epithelium structure in mice." American Journal of Physiology-Cell Physiology 300, no. 3 (2011): C466—C476. http://dx.doi.org/10.1152/ajpcell.00446.2010.

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Rab27 small GTPases regulate secretion and movement of lysosome-related organelles such as T cell cytolytic granules and platelet-dense granules. Previous studies indicated that Rab27a and Rab27b are expressed in the murine lung suggesting that they regulate secretory processes in the lung. Consistent with those studies, we found that Rab27a and Rab27b are expressed in cell types that contain secretory granules: alveolar epithelial type II (AEII) and Clara cells. We then used Rab27a/Rab27b double knockout (DKO) mice to examine the functional consequence of loss of Rab27 proteins in the murine

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8

Abdul Jalil, Youssef, Vera Ritz, Ana Jakimenko, et al. "Vesicular localization of the rat ATP-binding cassette half-transporter rAbcb6." American Journal of Physiology-Cell Physiology 294, no. 2 (2008): C579—C590. http://dx.doi.org/10.1152/ajpcell.00612.2006.

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The clarification of subcellular localization represents an important basis toward characterization of ATP-binding cassette (ABC) transporters and resolution of their roles in cellular physiology. Rat Abcb6 (rAbcb6) is a membrane-situated half-transporter belonging to the ABC protein superfamily. To investigate rAbcb6 subcellular distribution, the human colon adenocarcinoma line LoVo, which we found to be devoid of endogenous human ABCB6 mRNA, was employed for heterologous expression of rAbcb6 bearing a COOH-terminal epitope tag (rAbcb6-V5). Following subcellular fractionation, rAbcb6-V5 was o

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9

Surmacz, Liliana, Jolanta Wiejak, and Elzbieta Wyroba. "Cloning of two genes encoding Rab7 in Paramecium." Acta Biochimica Polonica 53, no. 1 (2005): 149–56. http://dx.doi.org/10.18388/abp.2006_3373.

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Rab7 is a small GTPase that plays a crucial role in the regulation of transport from early to late endosomes and lysosomes, phagosome maturation and in lysosomal biogenesis in mammalian cells. It contains conserved and unique sequence elements that mediate its function. Two Rab7 genes, Rab7a (703 bp) and Rab7b (707 bp) were identified in the unicellular eukaryote Paramecium by PCR amplification. They contain three short introns of different lengths (28-32 bp) and sequence located at identical positions in both genes. The presence of two Rab7 genes in the Paramecium genome was confirmed by Sout

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10

He, Donghua, Taoyong Chen, Mingjin Yang, et al. "Rab7b Promotes Megakaryocytic Differentiation of K562 Cells by Activating the Protein Kinase C/Extracellular Signal-Regulated Kinase Dependent Pathway." Blood 114, no. 22 (2009): 3612. http://dx.doi.org/10.1182/blood.v114.22.3612.3612.

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Abstract Abstract 3612 Poster Board III-548 Rab proteins are small GTPases belonging to the Ras superfamily and involved in cell protein transportation processes such as internalization and exocytosis. Recently it has been found that several Rab proteins such as Rab7 are also essential for signaling and the controlling of cell proliferation and differentiation. We previously have identified a small GTPase homologous to Rab7, named Rab7b, which is localized to lysosome-associated compartments and is selectively expressed in promyeloid or monocytic cells. We demonstrated that rab7b is involved i

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Lu, Peilin, Donghua He, Yang Yang, et al. "Rab7b suppresses autophagy and induces apoptosis of K562 leukemic cells treated with homoharringtonine." Blood 118, no. 21 (2011): 4884. http://dx.doi.org/10.1182/blood.v118.21.4884.4884.

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Abstract Abstract 4884 Homoharringtonine is an effective anti-leukemia medicine developed by Chinese. It has been found to induce differentiation and apoptosis of leukemia cells. However, the mechanism of its anti-leukemia function has not been fully understood. Rab is a kind of G protein of Ras superfamily and participates in endocytosis and exocytosis of protein transport process. In recent studies, some Rab proteins such as Rab7 are found to be associated with cellular autophagy and apoptosis. We previously identified a new small GTPase homologous to Rab7, named Rab7b, which is selectively

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12

Petry, Frauke, Vera Ritz, Cornelia Meineke, et al. "Subcellular localization of rat Abca5, a rat ATP-binding-cassette transporter expressed in Leydig cells, and characterization of its splice variant apparently encoding a half-transporter." Biochemical Journal 393, no. 1 (2005): 79–87. http://dx.doi.org/10.1042/bj20050808.

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Several transporters belonging to the ABCA subfamily of ABC (ATP-binding cassette) proteins are involved in lipid trafficking. Human ABCA5 and its rat orthologue, rAbca5, represent recently identified subfamily members whose substrate spectrum remains to be defined. The elucidation of (sub)cellular rAbca5 distribution would be expected to provide a basis for optimization of functional analyses. In the present study, we applied in situ hybridization to examine rAbca5 mRNA distribution within sections of rat testis, a tissue expressing high levels of rAbca5 mRNA. We found rAbca5 mRNA to be predo

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13

Kelly, Catriona, Paul Canning, Paul J. Buchanan, et al. "Toll-like receptor 4 is not targeted to the lysosome in cystic fibrosis airway epithelial cells." American Journal of Physiology-Lung Cellular and Molecular Physiology 304, no. 5 (2013): L371—L382. http://dx.doi.org/10.1152/ajplung.00372.2011.

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The innate immune response to bacterial infection is mediated through Toll-like receptors (TLRs), which trigger tightly regulated signaling cascades through transcription factors including NF-κB. LPS activation of TLR4 triggers internalization of the receptor-ligand complex which is directed toward lysosomal degradation or endocytic recycling. Cystic fibrosis (CF) patients display a robust and uncontrolled inflammatory response to bacterial infection, suggesting a defect in regulation. This study examined the intracellular trafficking of TLR4 in CF and non-CF airway epithelial cells following

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Anand, Shashi, Mohammad Aslam Khan, Moh’d Khushman, Santanu Dasgupta, Seema Singh, and Ajay Pratap Singh. "Comprehensive Analysis of Expression, Clinicopathological Association and Potential Prognostic Significance of RABs in Pancreatic Cancer." International Journal of Molecular Sciences 21, no. 15 (2020): 5580. http://dx.doi.org/10.3390/ijms21155580.

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RAB proteins (RABs) represent the largest subfamily of Ras-like small GTPases that regulate a wide variety of endosomal membrane transport pathways. Their aberrant expression has been demonstrated in various malignancies and implicated in pathogenesis. Using The Cancer Genome Atlas (TCGA) database, we analyzed the differential expression and clinicopathological association of RAB genes in pancreatic ductal adenocarcinoma (PDAC). Of the 62 RAB genes analyzed, five (RAB3A, RAB26, RAB25, RAB21, and RAB22A) exhibited statistically significant upregulation, while five (RAB6B, RAB8B, RABL2A, RABL2B,

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15

Beetler, Danielle, Kayleah Beltran, Kayla Lewis, and Verline Justilien. "4198 Investigating the Role of Rab27B in Non-Small Cell Lung Cancer Tumor Initiating Cells." Journal of Clinical and Translational Science 4, s1 (2020): 98. http://dx.doi.org/10.1017/cts.2020.306.

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OBJECTIVES/GOALS: Rab27B, a small GTPase, functions in exosome formation and secretion. Rab27B is overexpressed in non-small cell lung cancer (NSCLC) and predicts patient survival; however, little is known about its importance in NSCLC cells. Here, we investigated the role of Rab27B in NSCLC tumor initiating cells. METHODS/STUDY POPULATION: Tumor initiating cells (TICs) were enriched in a panel of NSCLC cell lines using low adherence spheroid cultures. QPCR and immunoblot analysis were used to compare Rab27B mRNA and protein expression, respectively, in adherent bulk cancer cells and TIC cultu

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16

Wang, Wei, Qichao Ni, Hua Wang, Shu Zhang, and Huijun Zhu. "Prognostic Value of Rab27B Nuclear Expression in Gastrointestinal Stromal Tumors." Disease Markers 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/942181.

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Rab proteins of the endocytosis and exocytosis pathways both play critical roles in cancer progression, and Rab27B has a significant relationship with several types of human cancer. However, the association between Rab27B expression and clinical features to determine its clinicopathological significance in gastrointestinal tumor (GIST) has not been investigated. To examine the expression of Rab27B in GIST and investigate the association between its expression and patient prognosis, immunohistochemistry analysis with tissue microarray was used to evaluate expression of Rab27B in 162 patients wi

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17

Gallo, Luciana I., Marianela G. Dalghi, Dennis R. Clayton, Wily G. Ruiz, Puneet Khandelwal, and Gerard Apodaca. "RAB27B requirement for stretch-induced exocytosis in bladder umbrella cells." American Journal of Physiology-Cell Physiology 314, no. 3 (2018): C349—C365. http://dx.doi.org/10.1152/ajpcell.00218.2017.

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Umbrella cells, which must maintain a tight barrier, modulate their apical surface area during bladder filling by exocytosis of an abundant, subapical pool of discoidal- and/or fusiform-shaped vesicles (DFVs). Despite the importance of this trafficking event for bladder function, the pathways that promote DFV exocytosis remain to be identified. We previously showed that DFV exocytosis depends in part on a RAB11A-RAB8A-MYO5B network, but RAB27B is also reported to be associated with DFVs, and knockout mice lacking RAB27B have fewer DFVs. However, the RAB27B requirements for DFV exocytosis and t

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18

Zhang, Louqian, Weifei Fan, Li Xu, et al. "Rab27b Is a Potential Indicator for Lymph Node Metastasis and Unfavorable Prognosis in Lung Adenocarcinoma." Disease Markers 2018 (December 2, 2018): 1–8. http://dx.doi.org/10.1155/2018/7293962.

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Rab27b is reported to associate with the development and progression of several types of human cancers. However, the relationship between Rab27b expression and the clinical characteristics of lung adenocarcinoma (LUAD) is rarely explored. In this present study, the TCGA database was consulted, followed by one-step quantitative reverse transcription polymerase chain reaction (qPCR), Western blot, and immunohistochemistry (IHC) analyses in LUAD cell lines and tissue samples. Rab27b expression levels were statistically higher in LUAD cell lines and tissue samples compared with a noncancerous cell

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19

Underwood, Rachel, Bing Wang, Christine Carico, Robert H. Whitaker, William J. Placzek та Talene A. Yacoubian. "The GTPase Rab27b regulates the release, autophagic clearance, and toxicity of α-synuclein". Journal of Biological Chemistry 295, № 23 (2020): 8005–16. http://dx.doi.org/10.1074/jbc.ra120.013337.

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α-Synuclein (αsyn) is the primary component of proteinaceous aggregates termed Lewy bodies that pathologically define synucleinopathies including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). αsyn is hypothesized to spread through the brain in a prion-like fashion by misfolded protein forming a template for aggregation of endogenous αsyn. The cell-to-cell release and uptake of αsyn are considered important processes for its prion-like spread. Rab27b is one of several GTPases essential to the endosomal-lysosomal pathway and is implicated in protein secretion and clearance, but i

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20

Zhao, Y. Z., X. L. Chen, D. G. Zeng, C. L. Yang, M. Peng, and X. H. Chen. "Molecular cloning, characterization, and expression of Rab5B, Rab6A, and Rab7 from Litopenaeus vannamei (Penaeidae)." Genetics and Molecular Research 14, no. 3 (2015): 7740–50. http://dx.doi.org/10.4238/2015.july.13.20.

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21

Bao, Jun, Yijiang Ni, Hui Qin, et al. "Rab27b Is a Potential Predictor for Metastasis and Prognosis in Colorectal Cancer." Gastroenterology Research and Practice 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/913106.

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Objective.Rab27b is reported to correlate with cancer development and progression. However, the association between Rab27b expression and the clinical characteristics of colorectal cancer (CRC) is barely investigated.Methods.One-step quantitative reverse transcription-polymerase chain reaction (qPCR) test with 18 fresh-frozen CRC samples and immunohistochemistry (IHC) analysis in 113 CRC cases were performed to explore the relationship between Rab27b expression and the clinicopathological features of CRC. Cox regression and Kaplan-Meier survival analyses were executed to evaluate the prognosis

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22

Tasaka, K., N. Masumoto, J. Mizuki, et al. "Rab3B is essential for GnRH-induced gonadotrophin release from anterior pituitary cells." Journal of Endocrinology 157, no. 2 (1998): 267–74. http://dx.doi.org/10.1677/joe.0.1570267.

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Gonadotrophin-releasing hormone (GnRH) induces the release of gonadotrophins via an increase in cytosolic Ca2+ concentration ([Ca2+]). Rab3B, a member of the small GTP-binding protein Rab family, is known to be involved in Ca(2+)-regulated exocytosis in pituitary cells. However, it is not known whether Rab3B functions in the physiological process regulated by GnRH in gonadotrophs. In this study using antisense oligonucleotide against Rab3B (AS-Rab3B) we determined that Rab3B is involved in GnRH-induced gonadotrophin release. Rab3B immunopositive cells were reduced in 24% of pituitary cells by

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23

Fukuda, M. "Rab27 and its effectors in secretory granule exocytosis: a novel docking machinery composed of a Rab27·effector complex." Biochemical Society Transactions 34, no. 5 (2006): 691–95. http://dx.doi.org/10.1042/bst0340691.

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A small GTPase Rab27 is present on secretory granules in a wide variety of secretory cells and on melanosomes in melanocytes, and it is involved in controlling the trafficking of these organelles through interaction with a cell-type- or tissue-specific Rab27 effector(s). Slps (synaptotagmin-like proteins) and rabphilin contain an N-terminal Rab27-binding domain and C-terminal tandem C2 domains, and some of the Rab27-binding proteins have recently been shown to promote docking of Rab27-bound organelles to the plasma membrane. This mini-review presents a model for how the Rab27·effector complex

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24

Parwati, Silpa, and Harisnal Hadi. "PENGARUH PERTUNJUKAN ORGEN TUNGGAL TERHADAP EKSISTENSI RABAB PASISIA DI KEC. LENGAYANG KABUPATEN PESISIR SELATAN." Jurnal Sendratasik 9, no. 4 (2020): 45. http://dx.doi.org/10.24036/jsu.v9i1.109539.

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This study aims to find and describe the effect of Orgen Tunggal performance on the existence of Rabab Pasisiain Kambang Village, Lengayang District, South Pesisir Regency. This is a qualitative research using a descriptivemethod. The main instrument in this study was the researcher it self and was assisted by supporting instruments such as writing instruments and cameras. The data were collected through literature study, observation, interview, and documentation. The steps for analyzing the data are collecting the data, describing the data, and making conclusions. The results show that Orgen

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25

Monetta, Pablo, Ileana Slavin, Nahuel Romero, and Cecilia Alvarez. "Rab1b Interacts with GBF1 and Modulates both ARF1 Dynamics and COPI Association." Molecular Biology of the Cell 18, no. 7 (2007): 2400–2410. http://dx.doi.org/10.1091/mbc.e06-11-1005.

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Assembly of the cytosolic coat protein I (COPI) complex at the ER–Golgi interface is directed by the ADP ribosylation factor1 (Arf1) and its guanine nucleotide exchange factor (GBF1). Rab1b GTPase modulates COPI recruitment, but the molecular mechanism underlying this action remains unclear. Our data reveal that in vivo expression of the GTP-restricted Rab1b mutant (Rab1Q67L) increased the association of GBF1 and COPI to peripheral structures localized at the ER exit sites (ERES) interface. Active Rab1b also stabilized Arf1 on Golgi membranes. Furthermore, we characterized GBF1 as a new Rab1b

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26

Wankel, Bret, Jiangyong Ouyang, Xuemei Guo, et al. "Sequential and compartmentalized action of Rabs, SNAREs, and MAL in the apical delivery of fusiform vesicles in urothelial umbrella cells." Molecular Biology of the Cell 27, no. 10 (2016): 1621–34. http://dx.doi.org/10.1091/mbc.e15-04-0230.

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Uroplakins (UPs) are major differentiation products of urothelial umbrella cells and play important roles in forming the permeability barrier and in the expansion/stabilization of the apical membrane. Further, UPIa serves as a uropathogenic Escherichia coli receptor. Although it is understood that UPs are delivered to the apical membrane via fusiform vesicles (FVs), the mechanisms that regulate this exocytic pathway remain poorly understood. Immunomicroscopy of normal and mutant mouse urothelia show that the UP-delivering FVs contained Rab8/11 and Rab27b/Slac2-a, which mediate apical transport

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Romero, Nahuel, Catherine I. Dumur, Hernán Martinez, et al. "Rab1b overexpression modifies Golgi size and gene expression in HeLa cells and modulates the thyrotrophin response in thyroid cells in culture." Molecular Biology of the Cell 24, no. 5 (2013): 617–32. http://dx.doi.org/10.1091/mbc.e12-07-0530.

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Rab1b belongs to the Rab-GTPase family that regulates membrane trafficking and signal transduction systems able to control diverse cellular activities, including gene expression. Rab1b is essential for endoplasmic reticulum–Golgi transport. Although it is ubiquitously expressed, its mRNA levels vary among different tissues. This work aims to characterize the role of the high Rab1b levels detected in some secretory tissues. We report that, in HeLa cells, an increase in Rab1b levels induces changes in Golgi size and gene expression. Significantly, analyses applied to selected genes, KDELR3, GM13

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Opdam, F. J., A. Echard, H. J. Croes, et al. "The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatus." Journal of Cell Science 113, no. 15 (2000): 2725–35. http://dx.doi.org/10.1242/jcs.113.15.2725.

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Members of the Rab subfamily of small GTPases play an important role in the regulation of intracellular transport routes. Rab6A has been shown to be a regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Here, we report on the identification of a Rab6 isoform, termed Rab6B. The corresponding full-length cDNA was isolated from a Caco-2 cell library. The deduced amino acid sequence showed 91% identity with the Rab6A protein and revealed that sequence divergence is dispersed over a large region of the COOH-terminal domain. Rab6B is encoded by an independe

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Striz, Anneliese C., Anna P. Stephan, Alfonso López-Coral, and Pamela L. Tuma. "Rab17 regulates apical delivery of hepatic transcytotic vesicles." Molecular Biology of the Cell 29, no. 23 (2018): 2887–97. http://dx.doi.org/10.1091/mbc.e18-07-0433.

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A major focus for our laboratory is identifying the molecules and mechanisms that regulate basolateral-to-apical transcytosis in polarized hepatocytes. Our most recent studies have focused on characterizing the biochemical and functional properties of the small rab17 GTPase. We determined that rab17 is a monosumoylated protein and that this modification likely mediates selective interactions with the apically located syntaxin 2. Using polarized hepatic WIF-B cells exogenously expressing wild-type, dominant active/guanosine triphosphate (GTP)-bound, dominant negative/guanosine diphosphate (GDP)

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Mashiach, Amir. "The Individual vs. Society in Rabbi Shlomo Zalman Auerbach’s Halakhic Rulings." Review of Rabbinic Judaism 20, no. 2 (2017): 251–71. http://dx.doi.org/10.1163/15700704-12341329.

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Rosh Yeshivat Kol Torah in Jerusalem for more than forty years, Rabbi Shlomo Zalman Auerbach was one of the most influential Halakhic decisors of the twentieth century. Rabbi Auerbach was a major figure in Haredi society which makes his Halakhic involvement in military issues more interesting. An examination of his Halakhic rulings in this matter shows that Rabbi Auerbach comprehended not only the complexity of being a religious soldier in the Army but also the complexity of the operational needs of the Army. Here I identify and analyze Rabbi Auerbach’s Halakhic rulings on military issues in t

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31

Sacks, Jonathan. "Rabbi Sacks." Chesterton Review 35, no. 1 (2009): 303–7. http://dx.doi.org/10.5840/chesterton2009351/252.

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NYE, RISA. "The Rabbi." Women's Studies 39, no. 1 (2009): 52–55. http://dx.doi.org/10.1080/00497870903368963.

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Amos, John. "KAMPANYE GIZI SEIMBANG MELALUI KESENIAN RABAB." Jurnal Sehat Mandiri 13, no. 2 (2018): 35–41. http://dx.doi.org/10.33761/jsm.v13i2.25.

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ABSTRACT The prevalence of underweight children under five in Indonesia is still high, compared to the target of Indonesia's MDGs of 18.5% West Sumatra is still below the target. Health problems can not only be solved by the government, but community involvement is required, therefore the potential needs to be mobilized. Rabab is a traditional Minangkabau traditional string instrument made from coconut shell. With this rabab can be channeled one's musical talents. Usually in this rabab narrated a variety of nagari stories or known by the term Kaba.merupakan a traditional theater that is

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Li, Rui, Chengyong Dong, Keqiu Jiang, et al. "Rab27B enhances drug resistance in hepatocellular carcinoma by promoting exosome-mediated drug efflux." Carcinogenesis 41, no. 11 (2020): 1583–91. http://dx.doi.org/10.1093/carcin/bgaa029.

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Abstract Liver cancer is a major threat to human life and health, and chemotherapy has been the standard non-surgical treatment for liver cancer. However, the emergence of drug resistance of liver cancer cells has hindered the therapeutic effect of chemical drugs. The discovery of exosomes has provided new insights into the mechanisms underlying tumour cell resistance. In this study, we aimed to determine the proteins associated with drug resistance in tumour cells and to elucidate the underlying mechanisms. We found that Rab27B expression in drug (5-fluorouracil, 5Fu)-resistant Bel7402 (Bel/5

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Magonet, Jonathan. "Rabbi Andre Ungar z’l." European Judaism 54, no. 1 (2021): 153–55. http://dx.doi.org/10.3167/ej.2021.540115.

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Rabbi Ungar was born in Budapest to Bela and Frederika Ungar. The family lived in hiding with false identity papers from 1944 under the German occupation. After the war, a scholarship brought him to the UK where he studied at Jews’ College, then part of University College, and subsequently studied philosophy. Feeling uncomfortable within Orthodoxy, he met with Rabbi Harold Reinhart and Rabbi Leo Baeck and eventually became an assistant rabbi at West London Synagogue. In 1954 he obtained his doctorate in philosophy and was ordained as a rabbi through a programme that preceded the formal creatio

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Piper Hanley, Karen, Tom Hearn, Andrew Berry, et al. "In vitro expression of NGN3 identifies RAB3B as the predominant Ras-associated GTP-binding protein 3 family member in human islets." Journal of Endocrinology 207, no. 2 (2010): 151–61. http://dx.doi.org/10.1677/joe-10-0120.

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Neurogenin 3 (NGN3) commits pancreatic progenitors to an islet cell fate. We have induced NGN3 expression and identified upregulation of the gene encoding the Ras-associated small molecular mass GTP-binding protein, RAB3B. RAB3B localised to the cytoplasm of human β-cells, both during the foetal period and post natally. Genes encoding alternative RAB3 proteins and RAB27A were unaltered by NGN3 expression and in human adult islets their transcripts were many fold less prevalent than those of RAB3B. The regulation of insulin exocytosis in rodent β-cells and responsiveness to incretins are relian

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Abenza, Juan F., Antonio Galindo, Mario Pinar, Areti Pantazopoulou, Vivian de los Ríos, and Miguel A. Peñalva. "Endosomal maturation by Rab conversion in Aspergillus nidulans is coupled to dynein-mediated basipetal movement." Molecular Biology of the Cell 23, no. 10 (2012): 1889–901. http://dx.doi.org/10.1091/mbc.e11-11-0925.

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We exploit the ease with which highly motile early endosomes are distinguished from static late endosomes in order to study Aspergillus nidulans endosomal traffic. RabSRab7 mediates homotypic fusion of late endosomes/vacuoles in a homotypic fusion- and vacuole protein sorting/Vps41–dependent manner. Progression across the endocytic pathway involves endosomal maturation because the end products of the pathway in the absence of RabSRab7 are minivacuoles that are competent in multivesicular body sorting and cargo degradation but retain early endosomal features, such as the ability to undergo long

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Magonet, Jonathan. "Editorial." European Judaism 53, no. 2 (2020): v—ix. http://dx.doi.org/10.3167/ej.2020.530201.

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This issue contains the papers given at a special conference held at Leo Baeck College (22 May 2019), ‘Albert Friedlander: Comprehension, Compassion and Conciliation’, reflecting on his life and achievements. Among his many activities and achievements, Rabbi Dr Albert Friedlander z’l (1927–2004) was editor of this journal (1982–2004) and we marked his passing with many personal tributes (European Judaism 37, no. 2 [Autumn 2004], 103–122). However, this conference provides an opportunity to explore different aspects of his life and work. Originally conceived by Rabbi Dr Frank Dabba Smith in con

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Lütcke, A., S. Jansson, R. G. Parton, et al. "Rab17, a novel small GTPase, is specific for epithelial cells and is induced during cell polarization." Journal of Cell Biology 121, no. 3 (1993): 553–64. http://dx.doi.org/10.1083/jcb.121.3.553.

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The rab subfamily of small GTPases has been demonstrated to play an important role in the regulation of membrane traffic in eukaryotic cells. Compared with nonpolarized cells, epithelial cells have distinct apical and basolateral transport pathways which need to be separately regulated. This raises the question whether epithelial cells require specific rab proteins. However, all rab proteins identified so far were found to be equally expressed in polarized and nonpolarized cells. Here we report the identification of rab17, the first epithelial cell-specific small GTPase. Northern blot analysis

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Sinichkin, Yaakov. "Тhe Image of Rabbi Yehudah ha-Nasi in Talmudic Literature". Tirosh. Jewish, Slavic & Oriental Studies 20 (2020): 54–70. http://dx.doi.org/10.31168/2658-3380.2020.20.1.1.

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The article examines a variety of sources from the Babylonian Talmud and the Midrash trying to establish why, despite the visible veneration of Rabbi Yehuda-ha-Nasi (called also just Rabbi, Rabbi Judas the Prince in Talmudic literature), he was also heavily and sharply criticized both for his moral character and his ways of management.

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Mashiach, Amir. "War and the Military in Rabbi Shlomo Zalman Auerbach’s Halakhic Decisions." Review of Rabbinic Judaism 21, no. 1 (2018): 134–49. http://dx.doi.org/10.1163/15700704-12341340.

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Abstract Rabbi Shlomo Zalman Auerbach (1910–1995) was one of the most influential Halakhic authorities of the twentieth century. Although he was an ultra-Orthodox rabbi, Rabbi Auerbach dealt with the complexity of army and military life. This article shows that he possessed of a clear “operational way of thinking,” reflecting deeply on the unique needs of the military of the Jewish State. Additionally, the article examines various approaches of filling the normative gap in issues of war and the military. Rabbi Auerbach based his specification of the Halakhah on his personal understanding and h

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Westreich, Elimelech. "Levirate Marriage in the State of Israel: Ethnic Encounter and the Challenge of a Jewish State." Israel Law Review 37, no. 2-3 (2004): 426–99. http://dx.doi.org/10.1017/s0021223700012528.

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AbstractThe article examines the approach of leading rabbis toward levirate marriages following the establishment of the State of Israel. Chief Ashkenazi Rabbi Herzog supported the abolishment of levirate marriages and attempted to impose on all ethnic communities the Ashkenazi approach, which since the 13th century favoredchalitza. Chief Sephardic Rabbi Uziel supported rabbi Herzog although the levirate commandment takes precedence overchalitzain the Sephardic and oriental traditions and is practiced in these communities. In 1950, the two Chief Rabbis led a council of rabbis that enacted a re

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Overmeyer, Jean H., Amy L. Wilson, Robert A. Erdman, and William A. Maltese. "The Putative “Switch 2” Domain of the Ras-related GTPase, Rab1B, Plays an Essential Role in the Interaction with Rab Escort Protein." Molecular Biology of the Cell 9, no. 1 (1998): 223–35. http://dx.doi.org/10.1091/mbc.9.1.223.

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Posttranslational modification of Rab proteins by geranylgeranyltransferase type II requires that they first bind to Rab escort protein (REP). Following prenylation, REP is postulated to accompany the modified GTPase to its specific target membrane. REP binds preferentially to Rab proteins that are in the GDP state, but the specific structural domains involved in this interaction have not been defined. In p21 Ras, the α2 helix of the Switch 2 domain undergoes a major conformational change upon GTP hydrolysis. Therefore, we hypothesized that the corresponding region in Rab1B might play a key ro

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Anita, Yesi, Nurman Nurman, and Aldri Frinaldi. "NILAI-NILAI MORAL YANG TERDAPAT DALAM KABA PADA KESENIAN RABAB (Studi pada Sebuah Pertunjukan Kesenian Rabab di Nagari Duku Kecamatan Koto XI Tarusan Kabupaten Pesisir Selatan Sumatera Barat)." Humanus 11, no. 1 (2012): 52. http://dx.doi.org/10.24036/jh.v11i1.623.

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This research aims to reveal religious and moral values in kaba (a type of Saga in Minangkabau literature) and rabab Pasisie (a type of percussion in Minangkabau particularly the one from Pesisir Selatan regency). The research is qualitative descriptive. The data, primary and secondary, is collected by observation, interview, and documentation. The interviewees are selected through purposive sampling. The data is then tested by triangulation of the sources, and then analysed using selection, reduction, classification, and presentation of data, which is later concluded. The result shows that ra

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Herberger, Tyson. "Jews and Judaism in Norway today." Nordisk Judaistik/Scandinavian Jewish Studies 29, no. 2 (2018): 36–42. http://dx.doi.org/10.30752/nj.70297.

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This address was given as part of a podium discussion on Judaism in Norway today held at the Jewish Museum in Oslo on 4 March 2018. Other participants in the panel were Rabbi Lynn Feinberg (Jewish Renewal movement), Rabbi Joav Melchior (Orthodox movement, current rabbi of Det Mosaiske Trossamfund in Oslo), Rabbi Shaul Wilhelm (Chabad shaliach in Oslo) and Professor Catherine Hezser (SOAS, London, and University of Oslo) as chair. The comments argue that Judaism in Norway is diverse and relatively unknown, with a majority of Jews in Norway probably being uncounted in current population estimate

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Plutner, H., A. D. Cox, S. Pind, et al. "Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments." Journal of Cell Biology 115, no. 1 (1991): 31–43. http://dx.doi.org/10.1083/jcb.115.1.31.

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We report an essential role for the ras-related small GTP-binding protein rab1b in vesicular transport in mammalian cells. mAbs detect rab1b in both the ER and Golgi compartments. Using an assay which reconstitutes transport between the ER and the cis-Golgi compartment, we find that rab1b is required during an initial step in export of protein from the ER. In addition, it is also required for transport of protein between successive cis- and medial-Golgi compartments. We suggest that rab1b may provide a common link between upstream and downstream components of the vesicular fission and fusion m

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Van Den Berg, José G., Jan Aten, Carla Annink, Jan H. Ravesloot, Ekkehard Weber, and Jan J. Weening. "Interleukin-4 and -13 promote basolateral secretion of H+ and cathepsin L by glomerular epithelial cells." American Journal of Physiology-Renal Physiology 282, no. 1 (2002): F26—F33. http://dx.doi.org/10.1152/ajprenal.0102.2001.

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Minimal change nephrosis (MCN) is characterized by massive proteinuria and ultrastructural alterations of glomerular visceral epithelial cells (GVEC). MCN has been associated with elevated production of interleukin (IL)-13 by circulating T lymphocytes and with T helper 2 lymphocyte-dependent conditions. We recently showed that GVEC express IL-4 and IL-13 receptors and that IL-4 and IL-13 increase transcellular ion transport over GVEC monolayers. We therefore hypothesized that IL-13 may directly injure GVEC. Here we demonstrate that IL-4 and IL-13 induce bafilomycin A1-sensitive basolateral pro

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Armstrong, J., N. Thompson, J. H. Squire, J. Smith, B. Hayes, and R. Solari. "Identification of a novel member of the Rab8 family from the rat basophilic leukaemia cell line, RBL.2H3." Journal of Cell Science 109, no. 6 (1996): 1265–74. http://dx.doi.org/10.1242/jcs.109.6.1265.

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We describe the cloning of a cDNA from the rat basophilic leukaemia cell line (RBL.2H3) encoding a novel member of the Rab family of small GTP binding proteins. The novel clone, which we call Rab8b, is most highly related to the Rab8 family with substantial divergence in the variable C-terminal domain. Northern blot analysis reveals highest levels of expression of Rab8b in the spleen, testis and brain, which is in marked contrast to the tissue distribution of Rab8. The Rab8b cDNA was modified to introduce a c-myc epitope tag at the extreme N terminus of the protein, and transient transfection

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Weber, E., G. Berta, A. Tousson, et al. "Expression and polarized targeting of a rab3 isoform in epithelial cells." Journal of Cell Biology 125, no. 3 (1994): 583–94. http://dx.doi.org/10.1083/jcb.125.3.583.

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Pathways of polarized membrane traffic in epithelial tissues serve a variety of functions, including the generation of epithelial polarity and the regulation of vectorial transport. We have identified a candidate regulator of polarized membrane traffic in epithelial cells (i.e., rab3B), which is a member of the rab family of membrane traffic regulators. Rab3B is highly homologous to a brain-specific rab3 isoform (rab3A) that targets in a polarized fashion to the presynaptic nerve terminal, where it probably regulates exocytosis. The coding region for human rab3B was cloned from epithelial mRNA

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Bayfield, Tony, Julia Neuberger, Alexandra Wright, Manuela Koska, and Britta Wauer. "Rabbi William (Willy) Wolff, Ze’ev ben Avraham v’LeahQ." European Judaism 54, no. 2 (2021): 145–60. http://dx.doi.org/10.3167/ej.2021.540216.

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