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1

Filopei, Jason, and William Frishman. "Radiation-Induced Heart Disease." Cardiology in Review 20, no. 4 (2012): 184–88. http://dx.doi.org/10.1097/crd.0b013e3182431c23.

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2

Heidenreich, P. A., and J. R. Kapoor. "Radiation induced heart disease." Heart 95, no. 3 (2008): 252–58. http://dx.doi.org/10.1136/hrt.2008.149088.

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3

Sebag-Montefiore, D., and H. Hope-Stone. "Radiation induced coronary heart disease." Heart 69, no. 6 (1993): 481–82. http://dx.doi.org/10.1136/hrt.69.6.481.

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4

Gujral, Dorothy M., Guy Lloyd, and Sanjeev Bhattacharyya. "Radiation-induced valvular heart disease." Heart 102, no. 4 (2015): 269–76. http://dx.doi.org/10.1136/heartjnl-2015-308765.

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5

Loyer, Evelyne M., and Ebrahim S. Delpassand. "Radiation-induced heart disease: Imaging features." Seminars in Roentgenology 28, no. 4 (1993): 321–32. http://dx.doi.org/10.1016/s0037-198x(05)80093-8.

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6

Lauk, Susanne, Zoltan Kiszel, Johannes Buschmann, and Klaus-Rüdiger Trott. "Radiation-induced heart disease in rats." International Journal of Radiation Oncology*Biology*Physics 11, no. 4 (1985): 801–8. http://dx.doi.org/10.1016/0360-3016(85)90314-1.

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7

Šteiner, Ivo. "Pathology of radiation induced heart disease." Reports of Practical Oncology & Radiotherapy 25, no. 2 (2020): 178–81. http://dx.doi.org/10.1016/j.rpor.2019.12.015.

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8

Yusuf, Syed Wamique, Shehzad Sami, and Iyad N. Daher. "Radiation-Induced Heart Disease: A Clinical Update." Cardiology Research and Practice 2011 (2011): 1–9. http://dx.doi.org/10.4061/2011/317659.

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Cardiovascular diseases and cancer are the two leading causes of morbidity and mortality worldwide. Improvement in cancer therapy has led to increasing number of cancer survivors, some of whom may suffer from adverse cardiovascular effects of radiation therapy. Longterm followup is essential, as the cardiac complication may manifest years after completion of radiation therapy. In this paper, we have discussed the cardiovascular effects of radiation therapy.
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9

Veeragandham, Ramesh S., and Marshall D. Goldin. "Surgical Management of Radiation-Induced Heart Disease." Annals of Thoracic Surgery 65, no. 4 (1998): 1014–19. http://dx.doi.org/10.1016/s0003-4975(98)00082-4.

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10

Lauk, Susanne, and Klaus-Rudiger Trott. "Radiation induced heart disease in hypertensive rats." International Journal of Radiation Oncology*Biology*Physics 14, no. 1 (1988): 109–14. http://dx.doi.org/10.1016/0360-3016(88)90058-2.

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11

Domoto, Satoru, Hiroshi Niinami, Fumiko Kimura, and Akimitsu Nasuno. "Clinical images of radiation-induced heart disease." European Heart Journal 35, no. 32 (2014): 2196. http://dx.doi.org/10.1093/eurheartj/ehu145.

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12

Mandraffino, G., A. Dalbeni, N. Paunovic, E. M. Mormina, and E. Imbalzano. "Radiation-induced heart and vessel atherosclerosis disease." International Journal of Cardiology 172, no. 2 (2014): 505–6. http://dx.doi.org/10.1016/j.ijcard.2014.01.059.

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13

Ming, Xin, Yuanming Feng, Chengwen Yang, Wei Wang, Ping Wang, and Jun Deng. "Radiation-induced heart disease in lung cancer radiotherapy." Medicine 95, no. 41 (2016): e5051. http://dx.doi.org/10.1097/md.0000000000005051.

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14

Prosnitz, Robert G., and Lawrence B. Marks. "Radiation-Induced Heart Disease: Vigilance Is Still Required." Journal of Clinical Oncology 23, no. 30 (2005): 7391–94. http://dx.doi.org/10.1200/jco.2005.07.011.

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15

Tapio, Soile. "Pathology and biology of radiation-induced cardiac disease." Journal of Radiation Research 57, no. 5 (2016): 439–48. http://dx.doi.org/10.1093/jrr/rrw064.

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Abstract Heart disease is the leading global cause of death. The risk for this disease is significantly increased in populations exposed to ionizing radiation, but the mechanisms are not fully elucidated yet. This review aims to gather and discuss the latest data about pathological and biological consequences in the radiation-exposed heart in a comprehensive manner. A better understanding of the molecular and cellular mechanisms underlying radiation-induced damage in heart tissue and cardiac vasculature will provide novel targets for therapeutic interventions. These may be valuable for individ
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16

Bergler-Klein, Jutta, Roza Badr Eslam, Matthias Schneider, Maria Frey, Mariann Gyoengyoesi, and Thomas Binder. "Radiation Induced Valve Disease and Cardiotoxicity Induced Heart Failure is Frequent." Structural Heart 3, sup1 (2019): 136. http://dx.doi.org/10.1080/24748706.2019.1589334.

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17

FRIEDLANDER, ARTHUR H., ERIC C. SUNG, and JOHN S. CHILD. "Radiation-induced heart disease after Hodgkin's disease and breast cancer treatment." Journal of the American Dental Association 134, no. 12 (2003): 1615–20. http://dx.doi.org/10.14219/jada.archive.2003.0108.

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18

Boerma, M., and M. Hauer-Jensen. "Potential Targets for Intervention in Radiation-Induced Heart Disease." Current Drug Targets 11, no. 11 (2010): 1405–12. http://dx.doi.org/10.2174/1389450111009011405.

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19

Boerma, M. "SP-0121: Experimental models of radiation-induced heart disease." Radiotherapy and Oncology 115 (April 2015): S57. http://dx.doi.org/10.1016/s0167-8140(15)40119-7.

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20

Madan, R., R. Benson, D. N. Sharma, P. K. Julka, and G. K. Rath. "Radiation induced heart disease: Pathogenesis, management and review literature." Journal of the Egyptian National Cancer Institute 27, no. 4 (2015): 187–93. http://dx.doi.org/10.1016/j.jnci.2015.07.005.

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21

Boerma, Marjan. "Experimental Radiation-Induced Heart Disease: Past, Present, and Future." Radiation Research 178, no. 1 (2012): 1–6. http://dx.doi.org/10.1667/rr2933.1.

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22

Jingu, Keiichi, Rei Umezawa, and Katsuya Fukui. "Radiation-induced heart disease after treatment for esophageal cancer." Esophagus 14, no. 3 (2017): 215–20. http://dx.doi.org/10.1007/s10388-017-0569-5.

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23

Boerma, M., and M. Hauer-Jensen. "Preclinical Research into Basic Mechanisms of Radiation-Induced Heart Disease." Cardiology Research and Practice 2011 (2011): 1–8. http://dx.doi.org/10.4061/2011/858262.

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Radiation-induced heart disease (RIHD) is a potentially severe side effect of radiotherapy of thoracic and chest wall tumors if all or part of the heart was included in the radiation field. RIHD presents clinically several years after irradiation and manifestations include accelerated atherosclerosis, pericardial and myocardial fibrosis, conduction abnormalities, and injury to cardiac valves. There is no method to prevent or reverse these injuries when the heart is exposed to ionizing radiation. This paper presents an overview of recent studies that address the role of microvascular injury, en
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24

Mahdavi, Hoda. "Radiation oncologists' perspectives on reducing radiation-induced heart disease in early breast cancer." Current Problems in Cancer 44, no. 2 (2020): 100509. http://dx.doi.org/10.1016/j.currproblcancer.2019.100509.

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25

Hoving, Saske, Ingar Seemann, Nils L. Visser, Johannes A. Te Poele, and Fiona A. Stewart. "Thalidomide is not able to inhibit radiation-induced heart disease." International Journal of Radiation Biology 89, no. 9 (2013): 685–91. http://dx.doi.org/10.3109/09553002.2013.788797.

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26

Gyenes, Gabor. "Radiation-Induced Heart Disease in Early Breast Cancer: Problem Solved?" Breast Diseases: A Year Book Quarterly 16, no. 1 (2005): 19–21. http://dx.doi.org/10.1016/s1043-321x(05)80003-7.

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27

Gyenes, Gábor. "Radiation-Induced Ischemic Heart Disease in Breast Cancer: A Review." Acta Oncologica 37, no. 3 (1998): 241–46. http://dx.doi.org/10.1080/028418698429522.

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28

Marinko, Tanja. "Pericardial disease after breast cancer radiotherapy." Radiology and Oncology 53, no. 1 (2018): 1–5. http://dx.doi.org/10.2478/raon-2018-0035.

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AbstractBackgroundBreast cancer is the second most common cancer worldwide. Thanks to the modern oncological treatments, disease specific survival has improved throughout the last decades. The number of breast cancer survivors has been increasing, and more and more attention has been paid to the breast cancer treatment side effects. Whereas there are many data regarding ischemic heart disease after radiotherapy for breast cancer, there is not much data in the literature about the incidence and clinical meaning of pericardial disease after breast cancer radiotherapy.ConclusionsAlthough radiatio
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29

Biserov, Denislav, Mariana Konteva, Ivaneta Yoncheva, and Svetoslav Gogov. "Coronary pathology in patients after chest radiotherapy." Bulgarian Cardiology 27, no. 2 (2021): 78–83. http://dx.doi.org/10.3897/bgcardio.27.e60233.

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Radiation therapy is the main treatment for a large number of neoplastic diseases. Improved survival in this group of patients led to the emergence of a new nosological unit – radiation-induced damage to neighbouring organs and systems. Data accumulated in recent decades has proven conclusively that chest radiotherapy could result in heart damage. Cardiovascular diseases are the leading cause of death in oncological patients in remission. The onset of radiation-induced heart disease (RIHD) can be early with clinical picture of acute myocarditis and late with manifestations of constrictive peri
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30

Ping, Zhang, Yang Peng, Hong Lang, et al. "Oxidative Stress in Radiation-Induced Cardiotoxicity." Oxidative Medicine and Cellular Longevity 2020 (March 2, 2020): 1–15. http://dx.doi.org/10.1155/2020/3579143.

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There is a distinct increase in the risk of heart disease in people exposed to ionizing radiation (IR). Radiation-induced heart disease (RIHD) is one of the adverse side effects when people are exposed to ionizing radiation. IR may come from various forms, such as diagnostic imaging, radiotherapy for cancer treatment, nuclear disasters, and accidents. However, RIHD was mainly observed after radiotherapy for chest malignant tumors, especially left breast cancer. Radiation therapy (RT) has become one of the main ways to treat all kinds of cancer, which is used to reduce the recurrence of cancer
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31

Gurses, I., M. Ozeren, M. Serin, N. Yucel, and H. S. Erkal. "Histopathological efficiency of amifostine in radiation‑induced heart disease in rats." Bratislava Medical Journal 119, no. 01 (2018): 54–59. http://dx.doi.org/10.4149/bll_2018_011.

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32

Donnellan, Eoin, Dermot Phelan, Cian P. McCarthy, Patrick Collier, Milind Desai, and Brian Griffin. "Radiation-induced heart disease: A practical guide to diagnosis and management." Cleveland Clinic Journal of Medicine 83, no. 12 (2016): 914–22. http://dx.doi.org/10.3949/ccjm.83a.15104.

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33

Wang, Heru, Jinlong Wei, Qingshuang Zheng, et al. "Radiation-induced heart disease: a review of classification, mechanism and prevention." International Journal of Biological Sciences 15, no. 10 (2019): 2128–38. http://dx.doi.org/10.7150/ijbs.35460.

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34

Hoving, S., I. Seemann, K. Gabriels, et al. "7 INVITED Possible Intervention Strategies to Reduce Radiation-induced Heart Disease." European Journal of Cancer 47 (September 2011): S4—S5. http://dx.doi.org/10.1016/s0959-8049(11)70222-2.

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35

Paven, E., M. Urena, C. Cimadevilla, et al. "Management of radiation-induced valvular heart disease in the modern area." Archives of Cardiovascular Diseases Supplements 10, no. 1 (2018): 84. http://dx.doi.org/10.1016/j.acvdsp.2017.11.308.

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36

Wu, Y. J., S. Wang, J. Wang, et al. "Chronic Intermittent Hypobaric Hypoxia Attenuates Radiation-Induced Heart Disease in Rat." International Journal of Radiation Oncology*Biology*Physics 93, no. 3 (2015): E544. http://dx.doi.org/10.1016/j.ijrobp.2015.07.1940.

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37

Eniseeva, Е. S., К. V. Protasov, N. L. Chernysheva, E. Yu Bagadaeva та A. A. Stefanenkova. "Radiation heart disease in a patient post treatment of Нodgkin’s lymphoma". Russian Journal of Cardiology, № 9 (24 вересня 2018): 45–47. http://dx.doi.org/10.15829/1560-4071-2018-9-45-47.

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A clinical case of radiation induced heart disease in 43 year old female patient after 15 years since radiation therapy of Hodgkin’s lymphoma. During clinical and instrumental investigation, a post-radiation constrictive pericarditis was found, comorbid with lesion of aortic, mitral and tricuspid valves. Surgical treatment of pericarditis was applied. Morphology confirmed the diagnosis.
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38

Kura, Branislav, Pavel Babal, and Jan Slezak. "Implication of microRNAs in the development and potential treatment of radiation-induced heart disease." Canadian Journal of Physiology and Pharmacology 95, no. 10 (2017): 1236–44. http://dx.doi.org/10.1139/cjpp-2016-0741.

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Radiotherapy is the most commonly used methodology to treat oncological disease, one of the most widespread causes of death worldwide. Oncological patients cured by radiotherapy applied to the mediastinal area have been shown to suffer from cardiovascular disease. The increase in the prevalence of radiation-induced heart disease has emphasized the need to seek new therapeutic targets to mitigate the negative impact of radiation on the heart. In this regard, microRNAs (miRNAs) have received considerable interest. miRNAs regulate post-transcriptional gene expression by their ability to target va
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39

Stewart, F. A. "Mechanisms and dose-response relationships for radiation-induced cardiovascular disease." Annals of the ICRP 41, no. 3-4 (2012): 72–79. http://dx.doi.org/10.1016/j.icrp.2012.06.031.

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Epidemiological studies have shown a clear association between therapeutic doses of thoracic irradiation and increased risk of cardiovascular disease in long-term cancer survivors. Survivors of Hodgkin's lymphoma and childhood cancers, for example, show 2- to >7-fold increases in risk of cardiac death after total tumour doses of 30–40 Gy, given in 2-Gy fractions. The risk of cardiac mortality increases linearly with dose, although there are large uncertainties for mean cardiac doses <5 Gy. Experimental studies show that doses of ⩾2 Gy induce the expression of inflammatory and thrombotic
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40

Pereira, Datson M., Kristin Stawiarski, Robert Fishman, and Irma Fotjadhi. "RADIATION INDUCED CORONARY HEART DISEASE IN A PATIENT WITH TREATED HODGKIN'S LYMPHOMA." Journal of the American College of Cardiology 75, no. 11 (2020): 3025. http://dx.doi.org/10.1016/s0735-1097(20)33652-4.

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41

Lauk, Susanne, Susanne Rüth, and Klaus-Rüdiger Trott. "The effects of dose-fractionation on radiation-induced heart disease in rats." Radiotherapy and Oncology 8, no. 4 (1987): 363–67. http://dx.doi.org/10.1016/s0167-8140(87)80187-1.

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42

Wu, Rong, and Yuecan Zeng. "Does angiotensin II–aldosterone have a role in radiation-induced heart disease?" Medical Hypotheses 72, no. 3 (2009): 263–66. http://dx.doi.org/10.1016/j.mehy.2008.09.051.

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43

Niv, Yaron, and Yaakov Henkin. "Estrogen-Progestin Therapy and Coronary Heart Disease in Radiation-induced Rectal Telangiectases." Journal of Clinical Gastroenterology 21, no. 4 (1995): 295–97. http://dx.doi.org/10.1097/00004836-199512000-00009.

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44

Sárközy, Márta, Zoltán Varga, Renáta Gáspár, et al. "Pathomechanisms and therapeutic opportunities in radiation-induced heart disease: from bench to bedside." Clinical Research in Cardiology 110, no. 4 (2021): 507–31. http://dx.doi.org/10.1007/s00392-021-01809-y.

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AbstractCancer management has undergone significant improvements, which led to increased long-term survival rates among cancer patients. Radiotherapy (RT) has an important role in the treatment of thoracic tumors, including breast, lung, and esophageal cancer, or Hodgkin's lymphoma. RT aims to kill tumor cells; however, it may have deleterious side effects on the surrounding normal tissues. The syndrome of unwanted cardiovascular adverse effects of thoracic RT is termed radiation-induced heart disease (RIHD), and the risk of developing RIHD is a critical concern in current oncology practice. P
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45

Wei, Shixiong, Lin Zhang, Huimin Cui, Lianggang Li, Tong Ren, and Shengli Jiang. "Surgery for Patients with Radiation-Induced Constrictive Pericarditis." Heart Surgery Forum 22, no. 6 (2019): E466—E469. http://dx.doi.org/10.1532/hsf.2501.

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Radiation-induced heart disease (RIHD) is a major side effect of chest radiation therapy (RT). Most changes of pericardium will occur within a few weeks after receiving chest RT, while most of them will take decades or more to become constrictive pericarditis. Pericardiectomy is an effective treatment method. Here, we report 2 cases of radiation pericarditis after chest RT at our center.
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46

Ma, Cheng-Xu, Xin-Ke Zhao, and Ying-Dong Li. "New therapeutic insights into radiation-induced myocardial fibrosis." Therapeutic Advances in Chronic Disease 10 (January 2019): 204062231986838. http://dx.doi.org/10.1177/2040622319868383.

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Radiation therapy (RT) for the treatment of thoracic tumors causes radiation-induced heart disease (RIHD). Radiation-induced myocardial fibrosis (RIMF) is both an acute and chronic stage of RIHD, depending on the specific pathology, and is thought to be a major risk factor for adverse myocardial remodeling and vascular changes. With the use of more three-dimensional conformal radiation regimens and early screenings and diagnoses for RIMF, the incidence of RIHD is declining, but it still must be carefully investigated to minimize the mortality and morbidity of patients with thoracic malignancie
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47

Schultz-Hector, S. "Radiation-induced Heart Disease: Review of Experimental Data on Dose Reponse and Pathogenesis." International Journal of Radiation Biology 61, no. 2 (1992): 149–60. http://dx.doi.org/10.1080/09553009214550761.

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48

Liu, Hui, Mai Xiong, Yun-Fei Xia, et al. "Studies on Pentoxifylline and Tocopherol Combination for Radiation-Induced Heart Disease in Rats." International Journal of Radiation Oncology*Biology*Physics 73, no. 5 (2009): 1552–59. http://dx.doi.org/10.1016/j.ijrobp.2008.12.005.

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49

Cuomo, Jason R., Sean P. Javaheri, Gyanendra K. Sharma, Deepak Kapoor, Adam E. Berman, and Neal L. Weintraub. "How to prevent and manage radiation-induced coronary artery disease." Heart 104, no. 20 (2018): 1647–53. http://dx.doi.org/10.1136/heartjnl-2017-312123.

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Radiation-induced coronary heart disease (RICHD) is the second most common cause of morbidity and mortality in patients treated with radiotherapy for breast cancer, Hodgkin’s lymphoma and other prevalent mediastinal malignancies. The risk of RICHD increases with radiation dose. Exposed patients may present decades after treatment with manifestations ranging from asymptomatic myocardial perfusion defects to ostial, triple-vessel disease and sudden cardiac death. RICHD is insidious, with a long latency and a tendency to remain silent late into the disease course. Vessel involvement is often diff
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50

Zou, Bingwen, Julius Philipp Schuster, Kerun Niu, Qianyi Huang, Alexander Rühle, and Peter Ernst Huber. "Radiotherapy-induced heart disease: a review of the literature." Precision Clinical Medicine 2, no. 4 (2019): 270–82. http://dx.doi.org/10.1093/pcmedi/pbz025.

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Abstract Radiotherapy as one of the four pillars of cancer therapy plays a critical role in the multimodal treatment of thoracic cancers. Due to significant improvements in overall cancer survival, radiotherapy-induced heart disease (RIHD) has become an increasingly recognized adverse reaction which contributes to major radiation-associated toxicities including non-malignant death. This is especially relevant for patients suffering from diseases with excellent prognosis such as breast cancer or Hodgkin’s lymphoma, since RIHD may occur decades after radiotherapy. Preclinical studies have enrich
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