Academic literature on the topic 'Radiation-induced lymphopenia'

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Journal articles on the topic "Radiation-induced lymphopenia"

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Wang, Xin, Peiliang Wang, Zongxing Zhao, Qingfeng Mao, Jinming Yu, and Minghuan Li. "A review of radiation-induced lymphopenia in patients with esophageal cancer: an immunological perspective for radiotherapy." Therapeutic Advances in Medical Oncology 12 (January 2020): 175883592092682. http://dx.doi.org/10.1177/1758835920926822.

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Radiotherapy is a frequently utilized therapeutic modality in the treatment of esophageal cancer (EC). Even though extensive studies are carried out in radiotherapy for EC, the design of the clinical target volume and the radiation dose is not satisfactorily uniform. Radiotherapy acts as a double-edged sword on the immune system; it has both an immunostimulatory effect and an immunosuppressive effect. Radiation-induced lymphopenia and its potential association with tumor control and survival outcomes remain to be understood. The advent of immunotherapy has renewed the focus on preserving a poo
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Ballal, Suhas, Shruti Chandak, Karan Ram Lal Gupta, and Geetika M. Patel. "A systematic review of the management and implications of radiation-induced lymphopenia and the predictive rate of radiomic-based approaches in lung cancer." Multidisciplinary Reviews 6 (January 29, 2024): 2023ss008. http://dx.doi.org/10.31893/multirev.2023ss008.

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Radiation therapy remains a crucial treatment option for lung cancer, but radiation-induced lymphopenia can impact treatment results and patient well-being. Radiomics-based techniques have made it easier to predict therapy response and patient outcomes by extracting and analyzing quantitative imaging characteristics. This review examines radiation-induced lymphopenia management and its consequences while evaluating the predictive capabilities of radiomics-based approaches in the lung cancer context. A systematic review was undertaken using Scinapse, Scholar and PubMed, with 1247 papers chosen
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Sashidharan, Srijith, Azadeh Abravan, Peter Sitch, Cy Howells, Ed Smith, and Shermaine Pan. "Radiation-induced lymphopenia with proton beam therapy (PBT)." Clinical Oncology 34 (September 2022): e2-e3. http://dx.doi.org/10.1016/j.clon.2022.08.009.

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Sengupta, Sadhak, Jaclyn Marrinan, Caroline Frishman, and Prakash Sampath. "Impact of Temozolomide on Immune Response during Malignant Glioma Chemotherapy." Clinical and Developmental Immunology 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/831090.

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Malignant glioma, or glioblastoma, is the most common and lethal form of brain tumor with a median survival time of 15 months. The established therapeutic regimen includes a tripartite therapy of surgical resection followed by radiation and temozolomide (TMZ) chemotherapy, concurrently with radiation and then as an adjuvant. TMZ, a DNA alkylating agent, is the most successful antiglioma drug and has added several months to the life expectancy of malignant glioma patients. However, TMZ is also responsible for inducing lymphopenia and myelosuppression in malignant glioma patients undergoing chem
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Yu, Hao, Fang Chen, Li Yang, Jian-Yue Jin, and Feng-Ming Spring Kong. "Potential determinants of radiation-induced lymphocyte decrease and lymphopenia in breast cancer patients by machine learning approaches." Journal of Clinical Oncology 39, no. 15_suppl (2021): e12567-e12567. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e12567.

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e12567 Background: Radiation-induced lymphopenia accompanied with radiation therapy is associated with inferior clinical outcomes in a wide variety of solid malignancies. This study aimed to examine the potential determines of radiation-induced lymphocyte decrease and radiation-induced lymphopenia in breast cancer patients who underwent radiotherapy. Methods: Patients with breast cancer treated who underwent radiotherapy were enrolled in University of Hong Kong-Shenzhen Hospital (our cohort). Circulating lymphocyte levels were evaluated within 7 days prior to and end of radiation therapy. Feat
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Jin, Jian-Yue, Todd Mereniuk, Anirudh Yalamanchali, et al. "A framework for modeling radiation induced lymphopenia in radiotherapy." Radiotherapy and Oncology 144 (March 2020): 105–13. http://dx.doi.org/10.1016/j.radonc.2019.11.014.

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Gupta, Priti, Min Wang, and Steven Lin. "Abstract 1118: Mitigating radiation-induced lymphopenia using interleukin-15: Preclinical rationale for clinical translation." Cancer Research 84, no. 6_Supplement (2024): 1118. http://dx.doi.org/10.1158/1538-7445.am2024-1118.

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Abstract Background: Radiation therapy is a common treatment for cancer patients, with nearly 50% of them undergoing this procedure. While radiation is effective at targeting tumor cells, it also has the unintended consequence of killing lymphocytes, which are among the most sensitive cells to radiation within the erythroid, myeloid, and lymphoid lineages. This phenomenon is known as radiation-induced lymphopenia (RIL) and is considered a negative prognostic factor in various malignant solid tumors. It occurs severely in over 40% of solid tumor patients who receive radiotherapy. Some previous
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Zhao, Qianqian, Tingting Li, Shisuo Du, Jian He, and Zhaochong Zeng. "Shortened Radiation Time Promotes Recovery From Radiation-induced Lymphopenia in Early-Stage Non-small Cell Lung Cancer Patients Treated With Stereotactic Body Radiation Therapy." Technology in Cancer Research & Treatment 21 (January 2022): 153303382211122. http://dx.doi.org/10.1177/15330338221112287.

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Background: To evaluate the potential impact of radiation time on radiation-induced lymphopenia (RIL) and subsequently recovery after stereotactic body radiation therapy (SBRT) and to examine the associations between radiation time and with patient outcomes in early-stage non-small cell lung cancer (NSCLC). Methods: Clinical and laboratory records of subjects consisted of 115 patients who had received SBRT for early-stage NSCLC. Clinical and laboratory records were retrospective reviewed to assess the changes in total lymphocyte counts (TLCs) following SBRT. Associations of TLCs kinetics with
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Ishida, Naoko, Yukinori Matsuo, Junki Fukuda, et al. "Radiation-Induced Lymphopenia and Its Impact on Survival in Patients with Brain Metastasis." Current Oncology 31, no. 8 (2024): 4559–67. http://dx.doi.org/10.3390/curroncol31080340.

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Background: Differences in radiation-induced lymphopenia and prognosis between methods of radiotherapy (RT) for brain metastases remain unclear. Methods: In this retrospective analysis of patients who underwent whole-brain radiotherapy (WBRT) or stereotactic radiosurgery/radiotherapy (SRS/SRT) for brain metastases, baseline total lymphocyte count (TLC) data were obtained within 2 weeks before RT initiation. Follow-up TLC data were evaluated at 0–2, 2–4, and 4–8 weeks after RT completion. Persistent lymphopenia was defined as <800/μL at any time point. Results: Overall, 138 RT courses in 128
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Alsamari, F., M. Aldehaim, A. Aldakheel, et al. "The Prognostic Significance of Radiation-Induced Lymphopenia in Nasopharyngeal Carcinoma." International Journal of Radiation Oncology*Biology*Physics 120, no. 2 (2024): e730. http://dx.doi.org/10.1016/j.ijrobp.2024.07.1605.

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Dissertations / Theses on the topic "Radiation-induced lymphopenia"

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Pham, Thao Nguyen. "Biοmathematical insights intο radiatiοn-induced systemic immune effects in brain and head & neck cancer using preclinical and clinical mοdels". Electronic Thesis or Diss., Normandie, 2024. http://www.theses.fr/2024NORMC407.

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La radiothérapie, bien qu'efficace contre les tumeurs, peut perturber le système immunitaire et provoquer une lymphopénie, ce qui impacte négativement les résultats du traitement. Des radiothérapies plus ciblées, telles que la protonthérapie, offrent des perspectives prometteuses pour réduire la lymphopénie. Au-delà de la lymphopénie, les sous-populations de leucocytes dans les lignées lymphoïde et myéloïde ont un impact significatif sur la réponse immunitaire antitumorale. Cette thèse examine l'impact de l'irradiation cérébrale sur le système immunitaire en utilisant la modélisation biomathém
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Conference papers on the topic "Radiation-induced lymphopenia"

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Rejeb, Mouna Ben, Ines Mlayah, Haifa Rachdi, et al. "1224 Radiation induced lymphopenia in patients with breast cancer: how can we reduce the risk?" In ESGO 2024 Congress Abstracts. BMJ Publishing Group Ltd, 2024. http://dx.doi.org/10.1136/ijgc-2024-esgo.1093.

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Sharma, Amrish, Shinya Neri, Bhanu P. Venkatesulu, and Steven H. Lin. "Abstract 473: Preclinical model of radiation induced lymphopenia to identify abrogation strategies to enhance cancer therapy." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-473.

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Hofer, T., AE Nieto, L. Kaesmann, et al. "P04.01 Early recovery of radiation induced lymphopenia in NSCLC stage III lung cancer: correlation with prognosis in a prospective study." In iTOC10 - 10th Immunotherapy of Cancer Conference, March 21 – 23, 2024 – Munich, Germany. BMJ Publishing Group Ltd, 2024. http://dx.doi.org/10.1136/jitc-2024-itoc10.36.

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