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1

吳楚儀 and Chor-yi Ng. "Radiation hazards of building materials." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1991. http://hub.hku.hk/bib/B3121051X.

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2

Corder, David A. "An instrumentation strategy for laser radiation safety assessments." Thesis, Loughborough University, 1997. https://dspace.lboro.ac.uk/2134/13972.

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The Maximum Permissible Exposure (MPE) to laser radiation defines a level below which an acute injury will not be sustained. Values for the MPE are defined by international standards, based on research into biological laser damage mechanisms and thresholds. To verify that a given laser installation does not present a hazard it is necessary to compare accessible levels of laser radiation to the MPE. In most cases this can only be done by a combination of measurement and calculation. The standard presents MPE values as tables of formulae. Users find the standards difficult to interpret and use for practical assessment tasks. It is shown by theoretical analysis and practical investigation that the measurement process is non-trivial. This research has identified that general purpose laser radiation measurement equipment is not capable of undertaking the critical pulsed measurements needed for MPE assessments. These instruments are usually limited to measurements of average power, or pulse energy over a limited range of pulse parameters. Analysis of the standards shows that energy measurement is a critical aspect of the radiation hazard assessment process. During the practical investigation a radiation hazard was demonstrated to exist in many laser displays used for entertainment purposes. To meet the measurement criteria laid down in the standard a novel detector strategy is developed to provide accurate pulse energy measurement. No single detector can meet these current criteria over the complete laser radiation spectrum. Three types of detector are used to measure the output of all common lasers. This leads to the concept of a modular instrument design, incorporating common detector interfaces with signal conditioning to provide a standard output signal format to an interface unit which extracts the relevant parameters from the data for processing by a palmtop computer. The software guides the user through the measurement process, controls the hardware, determines the measured radiation level from the data, calculates the appropriate MPE and displays the results. Techniques were developed to minimise the occurrence of user errors. This required consideration of human-computer interfacing techniques in the software design and unique coding of each instrument element. The measurement precision of the instrument was determined using stable laser and light emitting diode sources. A scanned laser display system was then used to determine the measurement precision of the combination of a typical source and the meter. It was found that the instrument precision exceeded that of the source, essential if the instrument measurement results were to be reliable. For safety critical instrumentation, calibration is identified as an important issue. Electrical and optical techniques are discussed. Alternative applications for the instrument were considered. A technique for high power laser measurement using a beam sampling technique was demonstrated. This had advantages when compared to traditional methods of high power laser measurement. The sampling technique was extended to the construction of a laser beam delivery monitor capable of monitoring beam power and position and shutting off the laser in the event of a fault developing. Since the completion of the research project the instrument has been developed commercially in collaboration with a UK company. The commercial instrument uses the same strategy, hardware and software designs as developed during the research project.
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3

Cordero, J. S. "Radiation model for buoyant flames." Thesis, University of Sheffield, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264618.

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4

Dong, Xiuqin. "Safety limit estimation for cataract induced by ultraviolet radiation /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-451-1/.

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5

Nicholson, Richard. "Radiation sensor interface ASSP designed for safety critical applications." Thesis, Lancaster University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497766.

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The aim of this research is to advance the state-of-the-art in instrumentation for safety critical radiation monitoring through the fusion of a novel high reliability smart sensor system methodology with the design of a novel ASSP integrated circuit. The sensor element for the demonstrator system has been designed by the National Radiological Protection Board (NRPB) and the National Physics Laboratory (NPL), in collaboration with the project sponsor, BNFPlc.
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6

Campos, Carlos Austerlitz. "Choice of personnel dosimeter location to assess the effective dose equivalent for various photon irradiations." Diss., Georgia Institute of Technology, 1990. http://hdl.handle.net/1853/12916.

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7

Veinot, Kenneth Guy. "An angular dependent neutron effective-dose-equivalent dosimeter." Diss., Georgia Institute of Technology, 1999. http://hdl.handle.net/1853/17595.

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8

Elmukhtar, Yasir Mohamed. "Knowledge and attitude of dentists regarding radiation safety in government dental clinics in Khartoum, Sudan." University of the Western Cape, 2015. http://hdl.handle.net/11394/5037.

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Magister Scientiae Dentium - MSc(Dent)
The level of knowledge and the attitude of dentists regarding radiation safety will have a direct impact on patient exposure to radiation. Aim: The aim of the present study was to evaluate the knowledge and attitude of dentists regarding radiation safety in government dental clinics in Khartoum, Sudan. Materials and Methods: A cross-sectional study using an administered structured questionnaire was carried out. The questionnaire consisted of 13 questions that included the demographic data of dentists, basic knowledge regarding radiation safety, knowledge of methods of dose reduction and the attitude of dentists regarding radiation safety. One hundred and sixty seven dental practitioners participated in the study. Results: The response rate was 90%. The majority were female, 59%, in the age group younger than 29 years with clinical experience less than 10 years. Only fifteen of the respondents identified themselves as specialist. Half of the respondents did not know that the thyroid gland is the most radiosensitive organ in the head and neck region. Forty four percent believed that the dose for panoramic radiography was higher than that for full mouth periapical radiographs. Forty percent had no idea that a relationship exists between the length of the x-ray cone and the amount of the dose and 44% who knew that the relationship existed, failed to explain that the long cone is more effective for reducing the patient dose. Forty seven percent of the respondents had no idea that there is a relationship between the speed of the film and the amount of dose and 44% who knew that the relationship existed, failed to explain that the fast film is more effective for reducing the patient dose. Sixty six percent had no idea that a relationship exists between collimation of the x-ray tube and patient dose. Forty six percent who knew the relationship existed, failed to explain that rectangular collimation is more effective for dose reduction. Seventy two percent of the dentists did not know what a safe distance from the radiation source was. Forty seven percent did not use film holders when taking periapical radiographs. Conclusions: This study clearly illustrates that there is a lack of knowledge regarding radiation safety in dentists in the government dental clinics in Khartoum, Sudan. Therefore there is a need to increase their knowledge regarding methods of radiation dose reduction (to patient) as well as improving their attitude regarding the radiation safety.
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9

Rhodes, Charles Ray III. "Development of an Automated Program for Calculating Radiation Shielding in a Radiotherapy Vault." University of Toledo Health Science Campus / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=mco1331557547.

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10

Shika, Matsepane Rebecca. "Radiation safety standards at public hospitals in Limpopo Province, South Africa." Thesis, University of Limpopo (Turfloop Campus), 2012. http://hdl.handle.net/10386/859.

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11

Jalandoni, D. Jay Moreno. "In-phantom measurement of HE or neutron protection dosimetry." Diss., Georgia Institute of Technology, 1996. http://hdl.handle.net/1853/16777.

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12

Reynolds, Patricia Ann. "An investigation into the safety of low level laser irradiation." Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243560.

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13

ESPOSITO, JANA C. G. "Instalações e uso seguro de lasers odontológicos." reponame:Repositório Institucional do IPEN, 2012. http://repositorio.ipen.br:8080/xmlui/handle/123456789/9926.

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Dissertacao (Mestrado Profissionalizante em Lasers em Odontologia)
IPEN/D-MPLO
Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP; Faculdade de Odontologia, Universidade de São Paulo, São Paulo
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14

Aldridge, Jesse Philmore. "The role of health physicists in contemporary radiological emergency response." Thesis, Georgia Institute of Technology, 1998. http://hdl.handle.net/1853/19434.

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15

Griffis, Neale Jeff. "Performance evaluation of the Dosicard electronic personal dosimeter." Thesis, Georgia Institute of Technology, 2001. http://hdl.handle.net/1853/16991.

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16

Kharkov, E., and N. Karaeva. "Automation of electromagnetic radiation monitoring as the factor of ecological safety maintenance." Thesis, Видавництво СумДУ, 2008. http://essuir.sumdu.edu.ua/handle/123456789/11741.

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17

Salikin, Md Saion. "An improved system of damage limitation for better risk control in radiological protection near environmental level." Thesis, University of St Andrews, 1995. http://hdl.handle.net/10023/13372.

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In radiological protection, models are used to assess radiation risk by means of extrapolation from high dose and dose rate to low dose and dose rate. In this thesis five main biophysical models of radiation action have been evaluated, appraised and inter-compared. The five models are lethal and potentially lethal (LPL) by Curtis, pairwise lesion interaction (PLI) by Harder, cellular track structure (CTS) by Katz, hit size effectiveness (HSE) by Bond and Varma and track core (TC) by Watt. Each model has been developed based on certain underlying mechanisms or phenomena, to permit interpretation and prediction on the induction of a specified biological endpoint such as cell reproductive death, chromosome aberrations and mutations. Biological systems of interest are, for example, mammalian cells containing deoxyribonucleic acid (DNA). Evidence is mounting that double strand breaks in the DNA are the critical lesions for various biological end points. To proceed with this work the TC model has been chosen. Cancer induction by ionising radiation is the stochastic effect of prime concern in radiological protection. Cancer induction cannot be avoided entirely but its frequency of occurrence may be reduced to acceptable level by lowering the amount of radiation received. The methods of assessment developed by ICRP, in terms of the cancer risk coefficients, are presented in this thesis. In the conventional (legal) system of dosimetry, radiation is quantified by the amount of energy absorbed per unit mass of tissue. Quality factors, superseded by radiation weighting factors, are needed to account for the quality dependence on radiation type. As an alternative, a new dosimetry system is proposed here which is based on the mean free path for primary ionisation along particle tracks and the integral fluence generated by the radiation field, whether directly or indirectly ionising radiation. From the study of cellular data, the mean free path for primary ionisation along particle tracks (lambda) emerges as a parameter which best unifies biological damage data. Radiation effect is found to depend, not on the energy transferred but to depend mainly on the frequency and spatial correlation of interactions. Maximum effect occurs when lambda is equal to lambda0 (2 nanometre, nm). The term 'Absolute Biological Effectiveness' (ABE) is introduced as a parameter which indicates the probability to induce a specified effect, per unit incident fluence. In this endeavour, only direct effects are considered in deriving ABE values for various radiations. However other factors such as indirect effects, inter-track action, repair processes and radiation rate, can be incorporated later if required, in the derivation of ABE. ABE values for photons up to 60Co i.e 1253 keV and neutrons up to 105 keV, have been calculated and presented in this thesis. An attempt has been made to re-express the cancer risk coefficients, derived by ICRP, in the new dosimetry system, in terms of the ABE (Absolute Biological Effectiveness). The hypothesis put forward in this thesis is that the induction of a specified biological-end-point in a biological system due to ionising radiations, is determined not by the amount of energy absorbed per unit mass (dose), but rather by the number of events (ionizations) spatially correlated, along the primary radiation track. Based on this hypothesis, a new unified dosimetry system, independent of radiation type, is proposed. Suggestions are made for possible measuring instruments which have the equivalent response characteristics, namely maximum efficiency of detection for the mean free path Success in devising such types of instrument would ensure the practicability of the new dosimetry system, in operational radiological protection.
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18

PANSINI, MARIO. "Avaliacao de requisitos de seguranca em lasers terapeuticos de baixa intensidade." reponame:Repositório Institucional do IPEN, 2001. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10971.

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Dissertacao (Mestrado Profissionalizante em Lasers em Odontologia)
IPEN/D-MPLO
Instituto de Pesquisas Energeticas e Nucleares, IPEN/CNEN-SP; Faculdade de Odontologia, Universidade de Sao Paulo
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19

Fulcher, TJ. "The development of an interlock and control system for a clinical proton therapy system." Thesis, Cape Technikon, 1995. http://hdl.handle.net/20.500.11838/1483.

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Thesis (Masters Diploma (Technology))--Cape Technikon, Cape Town, 1995
The development of a 200 MeV clinical proton therapy facility at the National Accelerator Centre required an interlock and control system to supervise the delivery of radiation to a patient. The interlock and control system is responsible for ensunng that nobody enters the treatment vault during an irradiation, the extraction of the beamstop devices 'from the beam-line to allow the irradiation of the patient and the insertion of those beam-stop devices when an error condition is detected. Because of its nature, the interlock and control system should be designed so that in the event of an error condition being detected, it should fail to a safe state. This is achieved by modelling the interlock and control system with an appropriate modeling method. This thesis describes a graphical modelling method called Petri-nets, which was used to model the system, and the software developed from the model.
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20

Witzel, Joy. "Operational and radiation safety guidelines for hand held intraoral x-ray systems a thesis /." San Antonio : UTHSC, 2008. http://learningobjects.library.uthscsa.edu/cdm4/item_viewer.php?CISOROOT=/theses&CISOPTR=21&CISOBOX=1&REC=11.

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21

陳木華 and Mok-wah Chan. "Exposures to artificial sources of ionising radiation in Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1989. http://hub.hku.hk/bib/B31208496.

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22

Zakariya, Nasiru Imam. "Development of nuclear-radiological facility monitoring system." Thesis, Cape Peninsula University of Technology, 2016. http://hdl.handle.net/20.500.11838/2182.

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Thesis (DTech (Electrical Engineering))--Cape Peninsula University of Technology, 2016.
The widespread application of nuclear science and technology has been the subject of much concern as well as nuclear safety issues. And to ensure the safety of public life, property and environment, it is indispensable to improve the emergency system for nuclear accidents and the environmental monitoring system for nuclear radiation, so that the occurrence of nuclear accidents, terrorist incidents and the resulting hazards can be prevented or minimized. Due to the benefits of radiation which were earlier and now recognized in the use of X-rays for medical diagnosis and then later with the discoveries of radiation and radioactivity, there was rush in exploiting the medical benefits which eventually led fairly to the recognition of the risks and induced harm associated with it. Thus, only the most obvious harms resulting from high doses of radiation, such as radiation burns, were initially observed and protection efforts were focused on their prevention, mainly for practitioners rather than patients. Subsequently, it was gradually recognized that there were other, less obvious, harmful radiation effects such as radiation-induced cancer, for which there is certain risk even at low doses of radiation.
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23

Weaver, Bess A. "Solar Ultraviolet Radiation Exposure in Outdoor Work Environment at Bowling Green, Ohio." University of Toledo Health Science Campus / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=mco1211995092.

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24

Watson, Jennifer A. "Designing, implementing, and conducting a Web-based radiation safety training program for a large biomedical research institution : a thesis /." San Antonio : UTHSC, 2008. http://learningobjects.library.uthscsa.edu/cdm4/item_viewer.php?CISOROOT=/theses&CISOPTR=22&CISOBOX=1&REC=5.

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25

Mitsuyoshi, Takamasa. "A pilot study on the safety and efficacy of dose escalation in stereotactic body radiotherapy for peripheral lung tumors." Kyoto University, 2018. http://hdl.handle.net/2433/232115.

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26

Boland, Joseph B. "The Cold War legacy of regulatory risk analysis : the Atomic Energy Commission and radiation safety /." view abstract or download file of text, 2002. http://wwwlib.umi.com/cr/uoregon/fullcit?p3055670.

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Thesis (Ph. D.)--University of Oregon, 2002.
Typescript. Includes vita and abstract. Includes bibliographical references (leaves 665-706). Also available for download via the World Wide Web; free to University of Oregon users.
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27

Johnson, Paul G. "EVALUATION OF FLUOROSCOPY RADIATION WORKER EXPOSURE AT A LARGE MEDICAL CENTER: IMPLICATIONS FOR UTILIZING GRAPHICAL FEEDBACK INFORMATION FOR IMPROVING OCCUPATIONAL SAFETY." Kent State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=kent1523631347981258.

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28

Savičiūtė, Rasa. "Medicinos personalo (gydytojų radiologų ir radiologijos laborantų), informuotumo apie gaunamą pacientų apšvitą ir radiacinę saugą tyrimas." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2010. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2008~D_20101125_185247-37918.

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Darbo tikslas - nustatyti ir įvertinti asmens svaikatos priežiūros įstaigų medicinos personalo (gydytojų radiologų ir radiologijos laborantų) informuotumą apie pacientų gaunamą apšvitą ir radiacinę saugą Vilniaus mieste. Tyrimo objektas – gydytojai radiologai ir radiologijos laborantai. Tyrimo metu buvo apklausti 140 respondentų iš 15 asmens sveikatos priežiūros įstaigų. Viso buvo apklausta 35 gydytojai radiologai (iš jų 15 vyrų ir 20 moterų) ir 105 radiologijos laborantai (iš jų 4 vyrai ir 101 moteris), o tai atitinkamai sudarė 25,0% ir 75,0%. Apklaustųjų amžius svyruoja nuo 23 iki 71 metų (vidurkis 47,43). Tyrimo tikslui ir uždaviniams pasiekti panaudotas aprašomasis tyrimo tipas bei anketinės apklausos metodas. Statistinė duomenų analizė atlikta naudojant SPSS 13 programos versiją. Pateikiamas rodiklių pasiskirstymas absoliučiais skaičiais ir procentais, apskaičiuotas chi kvadratas (Chi-kv.). Sirtumas statistiškai reikšmingas kai pasikliovimo lygmuo p<0,05. Atlikta mokslinių straipsnių, sveikatos sistemos teisinės ir normatyvinės medžiagos ir t.t., analizė. Gautos šios išvados: įvertinus bendrą žinių lygį tarp apklaustų respondentų, galima teigti, kad gydytojai radiologai ir radiologijos laborantai pakankamai gerai žino radiacinės saugos principus bei apšvitos keliamą pavojų. Tačiau atliktas tyrimas taip pat parodė, kad jiems vis dar trūksta žinių kai kuriais specifiniais klausimais, pavyzdžiui tokiais kaip tipinės efektinės dozės gaunamos atliekant įvairias procedūras... [toliau žr. visą tekstą]
Main task – to estimate and evaluate medical personnel’s of health care (doctors of radiology and radiology assistants) informativeness about receivable irradiance towards patients and radiational safety in city of Vilnius. Object of research - doctors of radiology and radiology assistants. During this research 140 respondents were questioned from 15 health care institutions. Overall 35 radiologists were questioned (15 men and 20 women), 105 radiology assistants (4 men and 101 women) and that’s accordingly 20, 0% and 75, 0%. Age variance of the respondents is from 23 up to 71 years old (average of 47.43 years old). Descriptive research type and survey was used in order to achieve the goals of this research. Statistical data analysis was performed by using SPSS program, version 13. The given distribution of index is in natural numbers and in percentage, Chi-square is counted (Chi-sq). Statistically the difference is meaningful when the level of probability is p<0,05. The analysis of science articles, law normative materials, health care systems, etc. was accomplished. The conclusion: after the evaluation of knowledge of the respondents it is clear that, doctors of radiology and radiology assistants have enough knowledge about radiational safety and dangers of irradiance. The research also revealed that they do not have enough knowledge concerning the specific topics, for example the doses that are received during variable procedures, the dependence of the dose, the observation... [to full text]
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29

Ho, Wing-kwok, and 何永國. "Solar ultraviolet radiation: monitoring, dosimetry and protection." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31222675.

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30

Murray, Bryon Michael. "Determination of eye dose from personnel monitoring devices in medical institutions." Thesis, Georgia Institute of Technology, 2001. http://hdl.handle.net/1853/17040.

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31

Glassford, Eric. "Comparison of Grab, Air, and Surface Results for Radiation Site Characterization." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1307442130.

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32

Van, der Walt Jacobus Gert. "Radiation field shaping through low temperature thermal-spray in radiotheraphy." Thesis, Bloemfontein : Central University of Technology, Free State, 2009. http://hdl.handle.net/11462/116.

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Thesis (D. Tech.) -- Central University of Technology, Free State, 2009
Superficial cancerous lesions are commonly treated through low energy X-ray or electron radiation in radiotherapy. The treatment units that produce the radiation are equipped with square, rectangular and round applicators of different sizes. These applicators attach to the treatment units and define the radiation field size applied during treatment. An applicator is chosen to fit the shape of the cancerous lesion on the patient as closely as possible. Since cancerous lesions are irregular in shape, there will always be an area of healthy tissue between the edge of the lesion and the edge of the standard field shape. This healthy tissue will be irradiated along with the lesion during treatment which is undesirable since the cancer wound heals through reparative growth of the surrounding healthy tissue after treatment. Traditional techniques that were developed to shield this healthy tissue and thus shape the radiation field to the shape of the lesion present various shortcomings. This study introduces a new thermal-spray process for producing radiation field shaping shields which overcomes most of the shortcomings encountered with the traditional field shaping techniques. Since none of the commercially available thermal-spray equipment could be used to produce field shaping shields, new thermal-spray equipment was designed and fabricated tailor made to the application. Different techniques to determine the contours of the treatment area on the patient were investigated. These included a patient contact technique using a plaster bandage impression and a non-contact technique using 3D laser scanning. From the plaster bandage impression a plaster model can be produced onto which a high density low melt material such as Wood’ s alloy can be thermally sprayed to produce a field shaping mask. A model can also be produced from the 3D laser scanning data through laser sintering (LS) in nylon polyamide powder or through computer numerical controlled (CNC) milling in a block of low density polyurethane. The thermal-spray technique was evaluated by comparing the field shaping ability of radiation shields produced through the technique to the field shaping ability of shields produced through the traditional techniques. Radiographic film was used for this purpose and the results are presented in the form of isodensity charts. The required thicknesses of thermal-sprayed field shaping masks to shield radiation of various energies were also determined. The thicknesses were determined through radiation transmission measurements of known thicknesses of sprayed sheets of Wood’ s alloy. X-ray imaging showed that there were no defects present within thermal-sprayed layers of Wood’ s alloy that may negatively affect the shielding ability of masks produced through the technique.
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33

Housenick-Lee, Megan. "Social-Ecological Factors Affecting Patient Shield Use Among Radiologic and Computed Tomography Technologists." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etd/3321.

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Medical radiation is estimated to contribute to over 200,000 deaths annually. Recent increases in the use of radiation-producing medical imaging examinations have led to increasing cumulative radiation dose to the general public. Multiple measures have been taken to address this alarming trend, including physician education, technologist education on dose reduction, and equipment-facilitated dose reduction techniques. Shield use can reduce the primary beam by up to 95%. Medical imaging technologists are the primary individuals responsible for applying shielding during an examination. Currently, literature shows that technologists are not shielding individuals as often as they should. After pilot testing, medical imaging technologists were recruited via email to participate in a national cross-sectional survey in September 2017. The survey contained items related to technologists’ demographics, shielding behaviors, and attitudes and beliefs measured at four social-ecological levels – intrapersonal, interpersonal, organizational, and community. The American Registry of Radiologic Technologists (ARRT) provided a list of technologists’ email addresses from their directory. One thousand six-hundred and sixty-one email notifications were sent out in the summer of 2017. Of those, 218 technologists (13%) completed the survey. Among technologists who considered their primary modality to be computed tomography (CT), organizational level factors were a positive significant predictor of shielding behavior. None of the four levels were significant in predicting shielding behavior among diagnostic radiological technologists (x-ray). Individual factors were significantly correlated to shielding behavior among radiologic technologists in the intrapersonal, organizational, and community levels. Study results indicated that interventions implemented at the organizational level may be most effective in increasing shield use among CT technologists. Additional research is needed to better understand factors affecting shield use among medical imaging technologists.
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Garvin, Theresa Dawn. "Evidence, policy and practice in environmental health : an international case study of sun safety /." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0033/NQ66209.pdf.

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35

Ghassemi, Hamed 1964. "Design and simulation of an improved operational amplifier for use in radiation environments." Thesis, The University of Arizona, 1989. http://hdl.handle.net/10150/276987.

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The effects of radiation on an operational amplifier were investigated through simulation. The μA 741 was simulated using Spice. Under normal conditions the 741 had the following properties: offset Voltage (Vos) of 0.8 mV, bias current (IB) of 27 nA, offset current (Ios) of 1 nA, and an open loop gain (A0.1.) of 112 dB. When exposed to neutron fluence of 5 x 10¹³ n/cm², these parameters changed to offset voltage of 45 mV, bias current of 1500 nA, offset current of 500 nA, and an open loop gain of 66 dB. A new circuit is proposed that provides improvements in the above parameters. The modified circuit gives a Vos of 3 mV, IB of 200 nA, Ios of 34 nA and A0.1. of 93 dB following exposure to a neutron fluence of 5 x 10¹³n/cm².
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36

Anderson, Anne Lee. "Assessment of thermal radiation arithmetic's for jet flames : A study involving generic calculation methods concerning radiation from jet flames with the purpose to determine the safety distance for flame effects." Thesis, Luleå tekniska universitet, Institutionen för samhällsbyggnad och naturresurser, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-67173.

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Jet flames are commonly used as flame effects in pyrotechnical shows, and are also a possible risk in industries that uses pressurised flammable gas. For these users it is important to  make fire safety engineering calculations to minimise the risks. This project focus on jet flames that are used in pyrotechnic shows where, e.g. it is important to determine the safety distance to the audience. Up to now most studies made concerning jet flames regards jet flames in subsonic regiments, whilst there is a lack of studies concerning sonic jet flames and mathematical formulations for radiation from these cases are limited. This makes pre-determination of temperatures, safety distances, flame heights etc. a challenge. Based on information found, and assumptions when needed, calculations of the safety distance were made.
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37

Wentling, II William A. II. "Economic Effects on Radiopharmacy Systems| The Impact of the Nuclear Regulatory Commission's Proposed Radiation Exposure Limits." Thesis, Robert Morris University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3629877.

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In the spring of 2012, based on recommendations from the International Commission on Radiological Protection (ICRP), the Nuclear Regulatory Commission (NRC) proposed three amendments to reduce current radiation exposure limits for radiation workers. The NRC proposals have caused some concern within the radiopharmaceutical industry. The regulatory changes may affect the ability of radiopharmacy workers to remain on the job, thereby inflicting additional costs to radiopharmacies if they are required to replace workers who have reached their yearly exposure limits.

This research sought to determine whether or not the new regulatory proposals will in fact have a financial impact on the radiopharmaceutical industry. This research was a retrospective case study that analyzed four radiopharmaceutical production facilities and their employee radiation exposure reports. Results of the study suggest that the NRC's proposed amendments to reduce radiation levels will not have a great adverse effect, either financially or from an employee exposure standpoint, on the current radiopharmacy system. The research demonstrated that existing as low as reasonably achievable (ALARA) standards have resulted in radiopharmacy workers receiving exposures well below the current limits, and within the NRC proposed limits. Of 77 employees studied over a 10 year period, only seven employees (9 %) would have been removed from the production process for overexposure to any one of the NRC's proposed limits. However, this research reviewed small a subset of four radiopharmacies and did not examine other industries and professions utilizing ionizing radiation.

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38

Mngxekeza, Siyabulela. "Realising the right to the highest attainable standard of health in the nuclear industry." University of the Western Cape, 2019. http://hdl.handle.net/11394/6974.

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Magister Legum - LLM
African states are interested in the development of nuclear power (also referred to as atomic power) for the generation of electricity and desalination. These include Algeria, Egypt, Ghana, Kenya, Morocco, Namibia, Niger, Nigeria, Tunisia, South Africa, and Uganda. The nuclear governance in South Africa has adopted principles into its legal system which require it to comply with the objectives of numerous resolutions, conventions, treaties, bilateral and multilateral agreements. Therefore, there is an obligation upon the government through ‘reasonable legislative and other measures’ to manage nuclear matters, such as nuclear accidents, in a manner that protects the general public, atomic industry workers as well as prevents the pollution of the surrounding environment. It has been seven years since the Fukushima Daiichi Nuclear Power Plant Accident that occurred in Japan on 11 March 2011, when considerable amounts of radioactive material from the damaged plant released into the environment. Health hazards, associated with exposure to low levels of ionising radiation, are a significant concern following such an accident. A nuclear disaster can potentially violate not only the right to health of workers, but that of residents and evacuees alike, particularly pregnant women, older persons, and children. Regional and international human rights conventions impose obligations on state parties to “take whatever steps necessary to ensure that the right to the highest attainable standard of health is enjoyed by all as soon as possible”. In most cases, when a nuclear accident occurs, workers within the nuclear plant are expected to mitigate emergencies. The danger of this expectation is that it could violate their fundamental human rights.
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39

Niemi, A. (Antti). "Röntgenhoitajien turvallisuuskulttuuri säteilyn lääketieteellisessä käytössä—Kulttuurinen näkökulma." Doctoral thesis, University of Oulu, 2006. http://urn.fi/urn:isbn:9514282949.

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Abstract The purpose of this study was to describe and interpret radiographers' safety culture in the medical use of radiation. Another objective was to yield new information and highlight inductively characteristics of radiographers' safety culture. The data were gathered from two different university hospitals and one central hospital. The data consisted of interviews (n=20), fieldwork (2 months in total), articles in a professional journal (n=457) and documents used by a radiographer in his work (n=21). The methodological basis of the study is that of interpretative and cognitive cultural studies. Focused ethnographic studies and discourse analysis were drawn on to interpret radiographers' shared meanings of safety culture. Radiographers' safety culture in the medical use of radiation consisted of four shared meanings: challenges of knowledge and skills structuring safety culture, dimensions of cooperation enabling safety culture, disorientation conditioning safety culture and multidimensional professionalism as the foundation of safety culture. The use of technology was considered an essential part of a radiographer's work, contributing to patient care. Traditional nursing was not considered to be part of a radiographer's tasks. The radiographers' varied assignments, their conventional opinions, the work and roles of both head radiographers' and physicians, and their responses to current social challenges in modern working life, all were seen as contributing to cooperation. The influx of new technology in radiographers' work demands continuous professional development. In relation to patients, other radiographers and operational environment, the Radiographer is a protector against radiation. Protection against radiation was understood to be an important part of the radiographer's standard activities. The significance of radiation protection was emphasized and it was considered to be essential factor in a radiographer's work. However radiographers were confused by the different directions and practices in implementing radiation protection. The results of the study can be used in developing and organizing radiographers' work and education. They may also clarify safety culture as a phenomenon and a concept in the medical use of radiation. Theoretical and methodological solutions can be applied also in other health related studies
Tiivistelmä Tutkimuksen tarkoituksena oli kuvailla ja tulkita röntgenhoitajien turvallisuuskulttuuria säteilyn lääketieteellisessä käytössä. Tavoitteena oli tuoda esille aineistolähtöisesti röntgenhoitajien turvallisuuskulttuurin erityispiirteet ja tuottaa uutta tietoa siitä. Aineisto kerättiin kahdesta eri yliopistosairaalan ja yhdestä keskussairaalan hoito-organisaatiosta. Aineisto koostuu tiedonantajien haastatteluista (n=20), kenttätyöstä (yhteensä 2 kuukautta), ammattilehtien artikkeleista (n=457) sekä röntgenhoitajien työssään käyttämistä dokumenteista (n=21). Turvallisuuskulttuurin jaettujen merkitysjärjestelmien tulkitsemiseksi sovellettiin tulkinnallisen ja kognitiivisen kulttuurintutkimuksen metodologisten lähtökohtien perustalta kohdennettua etnografista lähestymistapaa sekä diskurssianalyysia. Röntgenhoitajien turvallisuuskulttuuri säteilyn lääketieteellisessä käytössä muodostui neljästä jaetusta merkitysjärjestelmästä: osaamisen haasteet turvallisuuskulttuurin jäsentäjänä, yhteistyön ulottuvuudet turvallisuuskulttuurin mahdollistajana, hämmennys turvallisuuskulttuurin ehdollistajana sekä moniulotteinen ammatillisuus turvallisuuskulttuurin perustana. Tekniikan hyväksikäyttö nähtiin olennaiseksi osaksi röntgenhoitajan työtä, jolla vaikutetaan potilaan saamaan hoitoon. Perinteistä, sairaanhoitajan työhön perustuvaa hoitotyötä ei pidetty röntgenhoitajan omaan tehtävään kuuluvana. Yhteistyöhön vaikuttivat röntgenhoitajien monipuolistuneet tehtävät, perinteiset näkemykset röntgenhoitajien, osastonhoitajien ja lääkäreiden tehtävistä ja rooleista sekä vastaaminen nykyisen työelämän yhteiskunnallisiin haasteisiin. Uuden teknologian nopea tuleminen röntgenhoitajan työhön edellytti tietojen ja taitojen jatkuvaa ylläpitämistä ja kehittämistä. Röntgenhoitaja oli säteilysuojelijan roolissa suhteessa potilaisiin, muihin röntgenhoitajiin ja toimintaympäristöön. Säteilysuojelu nähtiin tärkeäksi osaksi röntgenhoitajan vastuullista toimintaa. Säteilysuojelun merkitystä korostettiin ja sitä pidettiin keskeisenä tekijänä röntgenhoitajan ammatissa. Röntgenhoitajia kuitenkin hämmensivät erilaiset ohjeistukset ja käytännöt säteilysuojelun toteuttamisessa. Tutkimustuloksia voidaan hyödyntää röntgenhoitajan työn kehittämisessä, koulutuksessa ja työn organisoinnissa. Tulokset voivat auttaa myös selkeyttämään turvallisuuskulttuuria ilmiönä ja käsitteenä säteilyn lääketieteellisessä käytössä. Tutkimuksen teoreettisia ja metodologisia ratkaisuja voidaan soveltaa myös muissa terveystieteellisissä tutkimuksissa
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40

Seydaliev, Marat Radikovich. "Development and Test of a GEM-Based TEPC for Neutron Protection Dosimetry." Diss., Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/14607.

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The effective dose equivalent, H (or the effective dose, E ) to an individual is the primary limiting quantity in radiation protection. However, techniques for measuring H for neutrons have not been fully developed. In this regard a new tissue equivalent proportional counter (TEPC) based on a gas electron multiplier (GEM) for measuring H*(10), which is a conservative estimate of H, for neutrons was designed and constructed. The deposited energy distribution for two different neutron sources (a Cf-252 source and a AmBe source) was measured using the new TEPC. The measurements were performed using two different proportional gases: P-10 gas and a propane-based tissue equivalent gas at various pressures. A computer simulation of the new TEPC, based on the Monte Carlo method, was performed in order to obtain the pulse height distributions for the two neutron sources. The simulated results and the measured results were compared. Results show that the experimental results agree with the computational results within 20% of accuracy for both Cf-252 and AmBe neutron sources. A new model GEM-based TEPC was developed for use in obtaining H*(10). The value of H*(10) for the Cf-252 source and for the AmBe source using experimental measurements was obtained. These results are presented in this study. The study shows that the GEM-based TEPC can successfully estimate H*(10). With these results and some refinements, this GEM-based TEPC can directly be used as a neutron rem meter.
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41

BRAGA, FLAVIO H. "Avaliacao de requisitos de seguranca e um equipamento a laser de erbio para fins odontologicos." reponame:Repositório Institucional do IPEN, 2002. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10964.

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Dissertacao (Mestrado Profissionalizante em Lasers em Odontologia)
IPEN/D-MPLO
Intituto de Pesquisas Energeticas e Nucleares, IPEN/CNEN-SP; Faculdade de Odontologia, Universidade de Sao Paulo
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42

CAMPOS, FABIO E. de. "Desenvolvimento de um modelo de cela para processamento de radiofarmacos injetaveis." reponame:Repositório Institucional do IPEN, 2010. http://repositorio.ipen.br:8080/xmlui/handle/123456789/9511.

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Dissertacao (Mestrado)
IPEN/D
Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP
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43

Pollock, Allison Maureen. "Characterization of pulsed light treatment on the shelf-life and safety of vacuum packaged cold smoked salmon." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101165.

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Listeria monocytogenes is a common post-processing contaminant in ready-to-eat vacuum packaged (VP) cold smoked salmon. Since this psychrotrophic pathogen can grow at refrigerated temperatures (~4°C), other safety barriers in addition to temperature are needed to ensure the continued safety of VP cold smoked salmon. One such novel barrier could be the pulsed light (PL) treatment of the product prior to packaging or treating the product through a transparent package.
Pulsed light destruction kinetics of L. monocytogenes were evaluated while dispensed into a liquid media, on the surface of a general purpose agar and on the surface of cold smoked salmon. Results showed that PL technology was an effective surface sanitation method (a decimal reduction time or D-value of 0.91, 1.37 and 2.25 s exposure of PL at 800, 700 and 600 V, respectively, and a resulting z value of 500 V) on the agar plate. However, it had only a limited success when applied to liquid samples as well as directly on the surface of cold smoked salmon (D-value ranged from 93 s to 24 min).
Sensory quality of VP cold smoked salmon subjected to selected PL treatments was monitored during storage for 14 days at 4°C. Both color and odor scores remained within acceptable limits over the 14 day storage period. Subsequent challenge studies were carried out with L. monocytogenes applied on VP cold smoked salmon. An overall reduction in counts was observed in samples stored at 4°C over 28 days; however, after PL treatment (day 0), there was no significant reduction in counts. Color and odor scores maintained acceptable values over 14 days. Additional experiments were carried out to determine the effects of (1) 1.5% salt, (2) 6% oil, (3) a representative salmon media and (4) background microflora (lactic acid bacteria) on the PL inactivation of L. monocytogenes. All of these factors significantly affected the destruction of L. monocytogenes by increasing the D-value (adding resistance to pulsed light destruction).
Overall, these studies have shown that PL treatment in combination with low temperature storage (4°C) has the potential to extend the shelf-life of VP cold smoked salmon products without compromising sensory quality. However further investigation into higher treatment voltages is necessary in order to achieve a higher target kill of L. monocytogenes.
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44

BARBOZA, ALEX. "Gestao de rejeitos radioativos em servicos de medicina nuclear." reponame:Repositório Institucional do IPEN, 2009. http://repositorio.ipen.br:8080/xmlui/handle/123456789/9377.

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Dissertacao (Mestrado)
IPEN/D
Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP
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45

Peters, Nazlea Behardien. "Determination of effective dose and entrance skin dose from dose area product values for barium studies in adult patients at a large tertiary hospital in the Western Cape." Thesis, Cape Peninsula University of Technology, 2017. http://hdl.handle.net/20.500.11838/2627.

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Thesis (MSc (Radiography))--Cape Peninsula University of Technology, 2018.
Background and objectives The issue of patient doses received during fluoroscopy procedures, raised concerns for the researcher, as there may have been probable past skin injuries or deterministic injuries that may not have been documented. Amongst the radiology staff, there was very little understanding of what the actual dose area product (DAP) value means in real terms of effective dose and entrance skin dose. The aims of the study were to: i) Measure the radiation doses received by the patient and determine a simple means of defining the DAP value to the radiographer in terms of the dose received by the patient. ii) Determine the effective dose, entrance skin dose and the relationship with the DAP value to assist with developing a conversion co-efficient for dose indicators. Method Direct radiation dose measurements can be obtained through DAP meters attached to the diagnostic equipment, but the DAP value is not an direct indication of the effective dose received by the patient. The DAP values captured from the DICOM header information for barium fluoroscopic procedures at a large tertiary was analysed and Diagnostic Reference levels (DRL) were determined for barium swallow, meal and enema procedures. The effective and skin doses were calculated by means of the Monte Carlo program. The results were compared to published values. The relationship between the entrance skin dose and the DAP value was determined and conversion factors were calculated. Results Correlation between the DAP and entrance skin dose and comparative 75th percentile threshold values were determined for barium swallow (BaS), barium meal (BaM) and barium enema (BaE) procedures. Effective to DAP conversation factors for BaS, BaM and BaE are 0.19, 0.26 and 0.60 respectively and 0.15, 0.11 and 0.14 for entrance skin to DAP. Conclusion The the research showed the relationship between the effective dose, entrance skin dose and DAP value and a simple, practical and applicable explanation of the DAP value by means of conversion factors.
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46

Jorge, Carlos Alexandre Fructuoso. "Received radiation dose assessment for nuclear plants personnel by video-based surveillance." Instituto de Engenharia Nuclear, 2015. http://carpedien.ien.gov.br:8080/handle/ien/1463.

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This work proposes the development of a system to evaluate received radiation dose for nuclear plants personnel. The system is conceived to operate in a complementary form to the existing approaches for radiological protection, thus o ering redundancy, what is desirable for critical plants operation. The proposed system must operate in an independent form on the actions to be performed by the operators under evaluation. Therefore, it was decided it would be based on methods used for video surveillance. The nuclear plant used as example is Argonauta Nuclear Research Reactor, belonging to Instituto de Engenharia Nuclear, Comiss~ao Nacional de Energia Nuclear (Nuclear Engineering Institute, National Nuclear Energy Commission). During this thesis research, both radiation dose rate distribution and video databases were obtained. Methods available in the literature, for targets detection and/or tracking, were evaluated for this database. From these results, a new system was proposed, with the purpose of meeting the requisites for this particular application. Given the tracked positions of each worker, the radiation dose received by each one during tasks execution is estimated, and may serve as part of a decision support system.
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47

Carlsson, Johan. "Inherent Safety Features and Passive Prevention Approaches for Pb/Bi-cooled Accelerator-Driven Systems." Doctoral thesis, KTH, Physics, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3503.

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This thesis is devoted to the investigation of passivesafety and inherent features of subcritical nucleartransmutation systems - accelerator-driven systems. The generalobjective of this research has been to improve the safetyperformance and avoid elevated coolant temperatures inworst-case scenarios like unprotected loss-of-ow accidents,loss-of-heat-sink accidents, and a combination of both theseaccident initiators. The specific topics covered are emergencydecay heat removal by reactor vessel auxiliary cooling systems,beam shut-off by a melt-rupture disc, safety aspects fromlocating heat-exchangers in the riser of a pool-type reactorsystem, and reduction of pressure resistance in the primarycircuit by employing bypass routes.

The initial part of the research was focused on reactorvessel auxiliary cooling systems. It was shown that an 80 MWthPb/Bi-cooled accelerator-driven system of 8 m height and 6 mdiameter vessel can be well cooled in the case of loss-of-owaccidents in which the accelerator proton beam is not switchedoff. After a loss-of-heat-sink accident the proton beam has tobe interrupted within 40 minutes in order to avoid fast creepof the vessel. If a melt-rupture disc is included in the wallof the beam pipe, which breaks at 150 K above the normal coreoutlet temperature, the grace period until the beam has to beshut off is increased to 6 hours. For the same vessel geometry,but an operating power of 250 MWth the structural materials canstill avoid fast creep in case the proton beam is shut offimmediately. If beam shut-off is delayed, additional coolingmethods are needed to increase the heat removal. Investigationswere made on the filling of the gap between the guard and thereactor vessel with liquid metal coolant and using water spraycooling on the guard vessel surface.

The second part of the thesis presents examinationsregarding an accelerator-driven system also cooled with Pb/Bibut with heat-exchangers located in the risers of the reactorvessel. For a pool type design, this approach has advantages inthe case of heat-exchanger tube failures, particularly if wateris used as the secondary uid. This is because a leakage ofwater from the secondary circuit into the Pb/Bi-cooled primarycircuit leads to upward sweeping of steam bubbles, which wouldcollect in the gas plenum. In the case of heatexchangers in thedowncomer steam bubbles may be dragged into the ADS core andadd reactivity. Bypass routes are employed to increase the owspeed in loss-of-ow events for this design. It is shown thatthe 200 MWth accelerator-driven system with heat-exchangers inthe riser copes reasonably well with both a loss-of-ow accidentwith the beam on and an unprotected loss-of-heat-sink accident.For a total-loss-of-power (station blackout) and an immediatebeam-stop the core outlet temperature peaks at 680 K. After acombined loss-of-ow and loss-of-heat-sink accident the beamshould be shut off within 4 minutes to avoid exceeding the ASMElevel D of 977 K, and within 8 minutes to avoid fast creep.Assuming the same core inlet temperature, both the reactordesign with heat-exchanger in the risers and the downcomershave similar temperature evolutions after a total-loss-ofpoweraccident.

A large accelerator-driven system of 800 MWth with a 17 mtall vessel may eventually become a standard size. For thishigher power ADS, the location of the heat-exchangers hasgreater impact on the natural convection capability. This isdue to that larger heatexchangers have more inuence on thedistance between the thermal centers during a lossof- owaccident. The design with heat-exchangers in the downcomers,the long-term vessel temperature peaks at 996 K during aloss-of-ow accident with the beam on. This does not pose athreat of creep rupture for the vessel. However, the locationof the heat-exchangers in the downcomers will probably requiresecondary coolant other than water, like for example oil (fortemperatures not higher than 673 K) or Pb/Bi coolant.

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48

SILVA, JONAS O. da. "Desenvolvimento de câmaras de ionização especiais para controle de qualidade em mamografia." reponame:Repositório Institucional do IPEN, 2013. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10507.

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Tese (Doutoramento)
IPEN/T
Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP
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49

Loy, Rodas Nicolas. "Context-aware radiation protection for the hybrid operating room." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAD001/document.

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L’utilisation de systèmes d’imagerie à rayons X lors de chirurgies mini-invasives expose patients et staff médical à des radiations ionisantes. Même si les doses absorbées peuvent être faibles, l’exposition chronique peut causer des effets nocifs (e.g. cancer). Dans cette thèse, nous proposons des nouvelles méthodes pour améliorer la sécurité vis-à-vis des radiations ionisantes en salle opératoire hybride dans deux directions complémentaires. Premièrement, nous présentons des approches pour rendre les cliniciens plus conscients des irradiations grâce à des visualisations par réalité augmentée. Deuxièmement, nous proposons une méthode d'optimisation pour suggérer une pose de l’imageur réduisant la dose au personnel et patient, tout en conservant la qualité de l’image. Pour rendre ces applications possibles, des nouvelles approches pour la perception de la salle grâce à des caméras RGBD et pour la simulation en temps-réel de la propagation et doses de radiation ont aussi été proposées
The use of X-ray imaging technologies during minimally-invasive procedures exposes both patients and medical staff to ionizing radiation. Even if the dose absorbed during a single procedure can be low, long-term exposure can lead to noxious effects (e.g. cancer). In this thesis, we therefore propose methods to improve the overall radiation safety in the hybrid operating room by acting in two complementary directions. First, we propose approaches to make clinicians more aware of exposure by providing in-situ visual feedback of the ongoing radiation dose by means of augmented reality. Second, we propose to act on the X-ray device positioning with an optimization approach for recommending an angulation reducing the dose deposited to both patient and staff, while maintaining the clinical quality of the outcome image. Both applications rely on approaches proposed to perceive the room using RGBD cameras and to simulate in real-time the propagation of radiation and the deposited dose
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50

Kotb, Shady. "Safety and radiosensitization properties of theranostic Gadolinium-based nanoparticles AGuIX®." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1330.

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La radiothérapie est souvent utilisée pour contrôler la progression d'un cancer. Cependant, la mauvaise spécificité de ciblage de la plupart des techniques de radiothérapie peut entraîner une réponse clinique ambiguë. Une stratégie alternative - et complémentaire - est d'utiliser des matériaux possédant un numéro atomique élevé et qui peuvent ainsi agir en synergie avec les rayonnements ionisants pour améliorer le ratio thérapeutique de la radiothérapie. Dans ce contexte, une nanoparticule (NP) théranostique à base de gadolinium (Gd) est particulièrement adaptée pour fournir simultanément une plus grande précision en Imagerie par Résonance Magnétique (IRM) et une meilleure efficacité en radiothérapie clinique. Au cours de cette thèse, nous avons étudié d'un point de vue préclinique la pharmacocinétique et le métabolisme de ces NP chez des rongeurs et des primates non humains afin d'élucider leurs voies d'élimination et de calculer la dose sans effet nocif observé (NOAEL). De plus, nous avons démontré la capacité d'imagerie et de thérapie de ces particules sur un modèle de souris porteuses de mélanome cérébral, ceci afin d'appuyer le potentiel des NP pour la radiothérapie guidée par IRM en clinique. Ces travaux de thèse - ainsi que des résultats précédents - ont contribué au début d'un essai clinique actuellement en cours
Combinations of chemotherapy and radiotherapy are often used to control cancer progression. However, the poor targeting specificity of most chemotherapies and radiotherapies can cause toxicity and ambiguous clinical response. In particular, dose escalation in radiotherapy inevitably increases radiation exposure for some surroundings normal tissues and organs, putting them at risk for debilitating damage. An alternative – and complementary – strategy is the use of materials with high atomic numbers (Z) that strongly interact with low energy photons to produce photoelectrons and Auger electrons In this context, a new efficient type of gadolinium (Gd)-based theranostic agent (AGuIX®) has recently been developed by the team of Prof. Tillement for MRI-guided radiotherapy. AGuIX® is a 3-nm size nanoparticles of 9 kDa, consist of a polysiloxane network surrounded by Gd chelates. In this thesis, we investigated the elimination kinetics of AGuIX nanoparticle’s (NPs) from sub-cellular to whole organ scale using original and complementary techniques. This combination of techniques allows the exact mechanism of AGuIX NPs elimination to be elucidated. We reported the preclinical pharmacokinetics and toxicology studies of intravenous AGuIX NPs administration in healthy and atherosclerosis non-human primates (NHP), the goal of which is to demonstrate the safety of AGuIX NPs, in particular, for pre-clinical evaluation. Subsequently, we performed experimental and theoretical studies to investigate the radiosensitization of AGuIX NPs, in particular with B16F10 mouse melanoma as a model for brain metastases. After, we implemented experimental and theoretical studies to precisely understand the mechanism of this radiosensitization, we suggest additional mechanism, potentially caused by chemical and biological effects induced by the combination of Gd and radiation (i.e. high yield of radicals formation and combination, and bystander effect)
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