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Dissertations / Theses on the topic 'Radiation Therapy Oncology Group'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Dial, Christian W. "Adaptive Radiation Therapy for Lung Cancer." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3579.

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Prognosis for lung cancer patients remains poor. For those receiving radiation therapy, local control and survival have been shown to improve with increased doses; however, deliverable dose is often limited by associated toxicity. Therefore, methods that reduce dose to normal tissues and allow isotoxic escalation are desirable. Adaptive radiation therapy seeks to improve treatment by modifying the initial plan throughout delivery, and has been shown to decrease normal tissue dose. Studies to date suggest a trend of increasing benefit with increases in replanning frequency; however, replanning

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2

Scott, Jacob G. "Mathematical modelling of tumour evolution and radiation response : the impact of heterogeneity." Thesis, University of Oxford, 2016. http://ora.ox.ac.uk/objects/uuid:a318d567-9f5c-4632-8fab-0ec3f4229a5e.

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This thesis seeks to use mathematical and computational models to develop measures of clinically available data to deepen our understanding, and improve our treatments, of cancer. We consider two broad characteristics of cancer: heterogeneity, in the form of differences in cellular phenotype, and the physical microenvironment; and evolution, which has become accepted as a driver of tumour progression. To ensure that the conclusions drawn are as translatable as possible, we will attempt to use data types that are clinically available. Using a hybrid discrete-cell-based model in two spatial dime

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3

Van, Jaarsveld Albert. "The role of adjuvant radiotherapy for breast cancer patients with axillary node negative or limited nodal disease after total mastectomy, axillary nodal clearance and systemic therapy." Master's thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/5931.

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4

Price, Ryan Glen. "Toward magnetic resonance only treatment planning| Distortion mitigation and image-guided radiation therapy validation." Thesis, Wayne State University, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10153444.

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<p> While MR-only treatment planning has shown promise, there are still several well-known challenges that are currently limiting widespread clinical implementation. Firstly, MR images are affected by both patient-induced and system-level geometric distortions that can significantly degrade treatment planning accuracy. In addition, the availability of comprehensive distortion analysis software is currently limited. Also while many groups have been working toward a synthetic CT solution, further study is needed on the implementation of synCTs as the reference datasets for linac-based image-guid

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5

Reddy, Bhiskar. "Dosimetric comparison of volumetric modulated arc therapy and three dimensional conformal radiotherapy in the adjuvant setting for the management of gastric cancer : target volume coverage and normal tissue sparing." Master's thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/12943.

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Includes bibliographical references.<br>Whilst the benefit of adjuvant radiotherapy in gastric cancer is known, the optimal means of delivery, including two dimensional conventional, three dimensional conformal radiotherapy, intensity modulated radiotherapy and volumetric modulated arc therapy is less certain. The purpose of this study is to assess and compare volumetric modulated arc therapy (VMAT) and three dimensional conformal radiotherapy (3DCRT) plans in adjuvant radiation of gastric cancer.

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6

Cutter, David J. "Radiation-related cardiovascular disease following cancer therapy." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:3f02ca87-530d-4ee7-9382-4b457bec62b5.

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<b><u>Introduction:</b></u> Some cancer survivors are known to have an elevated risk of morbidity and mortality from cardiovascular disease. An important cause of this elevated risk is recognised to be irradiation of normal tissues during radiotherapy received as part of cancer therapy. There are substantial difficulties in studying radiation-related cardiovascular disease (RRCD). The reasons for this include the complexities of measuring radiation normal tissue doses retrospectively and the prolonged latencies of many of the cardiovascular endpoints. A variety of complimentary research method

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7

Abdelhamid, S. "Respiratory motion modelling and predictive tracking for adaptive radiotherapy." Thesis, Coventry University, 2010. http://curve.coventry.ac.uk/open/items/f135cb12-e9f9-1e4f-9c57-6de2fc378069/1.

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External beam radiation therapy (EBRT) is the most common form of radiation therapy (RT) that uses controlled energy sources to eradicate a predefined tumour volume, known as the planning target volume (PTV), whilst at the same time attempting to minimise the dose delivered to the surrounding healthy tissues. Tumours in the thoracic and abdomen regions are susceptible to motion caused mainly by the patient respiration and movement that may occur during the treatment preparation and delivery. Usually, an adaptive approach termed adaptive radiation therapy (ART), which involves feedback from ima

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8

Cooper, Benjamin James. "On the investigation of a novel x-ray imaging techniques in radiation oncology." Thesis, The University of Sydney, 2019. http://hdl.handle.net/2123/20575.

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Radiation therapy is indicated for nearly 50% of cancer patients in Australia. Radiation therapy requires accurate delivery of ionising radiation to the neoplastic tissue and pre-treatment in situ x-ray imaging plays an important role in meeting treatment accuracy requirements. Four dimensional cone-beam computed tomography (4D CBCT) is one such pre-treatment imaging technique that can help to visualise tumour target motion due to breathing at the time of radiation treatment delivery. Measuring and characterising the target motion can help to ensure highly accurate therapeutic x-ray beam deliv

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9

Pollard, Anné Francoisé. "Group music therapy in a paediatric oncology ward working with a wide open group in a wide open space /." Pretoria : [s.n.], 2007. http://upetd.up.ac.za/thesis/available/etd-10072008-132209/.

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10

Peet, Samuel. "Out-of-field dosimetry in contemporary radiation therapy." Thesis, Queensland University of Technology, 2022. https://eprints.qut.edu.au/234916/1/9325565_samuel_peet_thesis.pdf.

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Radiation therapy is a beneficial treatment for approximately half of all people diagnosed with cancer. This project improved the safety of radiation therapy for several vulnerable cohorts: pregnant patients, patients with electronic implants such as pacemakers, and young people at risk of developing secondary cancers later in life. In doing so, this research furthered equitable access to safe, high-quality health care.

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11

Waldon, Eric G. "The effects of group music therapy on mood states and cohesiveness in adult oncology patients." Scholarly Commons, 2000. https://scholarlycommons.pacific.edu/uop_etds/534.

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The purpose of the current investigation was to examine the efficacy of a music therapy protocol on mood states and levels of group cohesiveness in adult oncology patients. Eleven oncology patients in two groups (ages 30 to 84 years) took part in the study over a ten-week period of time (ten participants completed the study). During that period, participants took part in eight music therapy sessions consisting of two types of interventions: 1) four "music making" sessions (where the mechanism for change included the process of making music) and 2) four "music responding" sessions (where the me

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12

Wong, Victy Yee Wa. "Four-dimensional radiation therapy for thoracic carcinoma : dosimetric evaluation using deformable image registration." Thesis, University of Liverpool, 2012. http://livrepository.liverpool.ac.uk/9215/.

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Respiratory motion remains a significant challenge for radiation therapy in targeting the tumour. The use of planning margins to avoid geometrical miss of the target volume during respiration results in excessive lung tissue irradiation that limits the prescribed dose to be safely delivered and escalated for better therapeutic gain. The purpose of this study was to develop effective dose planning techniques for treatment to be performed under natural patient breathing. The techniques accounted for the dosimetric influences of tumour movement and aimed to provide an optimized treatment volume b

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13

Fortin, Bernard 1970. "Waiting time for radiation therapy in non-metastatic, surgically-treated breast cancer patients in Quebec." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80266.

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The purpose of this study was to determine among surgically treated non-metastatic breast cancer patients in the province of Quebec the distribution of the time between surgery and post-operative radiation therapy (RT) as well as secular trends and other factors influencing waiting time. Using administrative records, I identified between 1992 and 1998 29,105 episodes of breast cancer and 17,704 of these contained an indication of receiving RT Hierarchical linear regression models were used to identify predictors of waiting time.<br>The number of cases of breast cancer increased by 5.5%

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14

Robar, Vlado. "Characteristic angle-beta concept in electron arc therapy." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=24037.

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Electron arc therapy is the treatment of choice for tumours involving large curved surfaces. At the Montreal General Hospital a unique approach to the electron arc therapy was developed in 1986 and has been used clinically ever since. The approach is based on the concept of the characteristic angle beta.<br>We measured radial percentage depth doses in a polystyrene cylindrical phantom irradiated with electron arc beams having angles beta in the range from 5$ sp circ$ to 100$ sp circ,$ for 9 MeV, 12 MeV, 15 MeV, and 18 MeV electron beam energies. We showed that the characteristic angle-$ beta$

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15

Adamson, Laura. "Safety Culture and Incident Learning Systems in Radiation Oncology across Australia and New Zealand." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/27813.

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Radiation therapy is a highly complex cancer treatment using individualised patient plans to provide treatment over multiple fractions. The treatment planning and delivery process requires high dosimetric and geometric precision overall but has multiple steps and interfaces that have the potential to introduce error. Three primary radiation oncology professional groups work closely together to safely and accurately accomplish the many steps within the patient pathway: radiation oncologists, radiation oncology medical physicists and radiation therapists. Radiation oncology incorporates detaile

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16

Pollard, Anne Francoise, and Anne Francoise Pollard. "Group music therapy in a paediatric oncology ward : working with a wide open group in a wide open space." Diss., University of Pretoria, 2007. http://hdl.handle.net/2263/31335.

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This mini-dissertation is structured as a clinical inquiry based on a detailed analysis of music therapy work with a wide open group at Kalafong Hospital’s paediatric oncology ward. The focus of this inquiry is to characterise ‘working moments’ within a wide open group music therapy context, that appears to be impacted by noise levels, group structures, and a generally busy and unpredictable physical environment. In addition, this clinical inquiry identifies clinical skills employed during ‘working moments’ with a wide open group. Research methods of description, coding, categorising and theme

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17

Winkler, Stephanie S. "Considering the oxygen effect| Further development of a volumetric model of tumor response to radiation therapy for cervical cancer." Thesis, East Carolina University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=1565008.

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<p> Mathematical modeling of tumor response to radiation therapy (RT) has great potential for designing therapy plans that are more personalized, more adaptive, and more reliable for outcome predictions. A preexisting model of tumor response to radiation therapy for cervical cancer has been shown to generate model parameters that correlate strongly with both tumor local control and disease-specific survival. This model is further developed through incorporation of another effect of RT not previously accounted for: the oxygen effect. An easily obtainable form of input data, hemoglobin level, en

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18

Bham, Saif Ahmed Shahab. "Role of delta-like 4 in solid tumours and response to radiation therapy." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:f977581c-a460-4876-9ce4-dcbe9494aa1e.

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Delta-like ligand 4 (DLL4) is a ligand for the Notch family of receptors. DLL4 is an important regulator of angiogenesis and DLL4 blockade promotes non-productive angiogenesis and delays tumour growth. The aim of this thesis was to investigate the effects of anti-DLL4 therapy in solid tumours in combination with a clinically relevant dose of ionising radiation (5 Gy; IR) and to analyse alterations in the Notch pathway induced by the treatments. Combining both treatments resulted in a greater than additive tumour growth delay in LS174T tumours, compared to either treatment alone. DLL4 blockade

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19

Waldon, Eric G. "The effects of group music therapy on mood states and cohesiveness in adult oncology patients : a thesis." Scholarly Commons, 2001. https://scholarlycommons.pacific.edu/uop_etds/534.

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The purpose of the current investigation was to examine the efficacy of a music therapy protocol on mood states and levels of group cohesiveness in adult oncology patients. Eleven oncology patients in two groups (ages 30 to 84 years) took part in the study over a ten-week period of time (ten participants completed the study). During that period, participants took part in eight music therapy sessions consisting of two types of interventions: 1) four "music making" sessions (where the mechanism for change included the process of making music) and 2) four "music responding" sessions (where the me

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20

Kegelman, Timothy P. "MDA-9/Syntenin: From Glioblastoma Pathogenesis to Targeted Therapy." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/4676.

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The most common malignant glioma, glioblastoma multiforme (GBM), remains an intractable tumor despite advances in therapy. Its proclivity to infiltrate surrounding brain tissue contributes greatly to its treatment failure and the grim prognosis of patients. Radiation is a staple in modern therapeutic regimens, though cells surviving radiation become more aggressive and invasive. Consequently, it is imperative to define further the cellular mechanisms that control GBM invasion and identify promising novel therapeutic targets. Melanoma differentiation associated gene-9 (MDA-9/Syntenin) is a high

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21

Rawal, Malvika. "Manganoporphyrins as adjuvants to enhance pharmacological ascorbate in pancreatic cancer therapy." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/5046.

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With new insights on mechanism, there is renewed interest in the use of pharmacological ascorbate (AscH-) in cancer therapy. The generation of H2O2 with AscH- acting as an electron donor to O2 is central to AscH- -induced cytotoxicity. We hypothesized that catalytic manganoporphyrins (MnPs) would increase the rate of oxidation of AscH- thereby increasing the flux of H2O2, resulting in increased cytotoxicity. We tested three different MnPs: MnTBAP, MnT2EPyP, and MnT4MPyP, which represent a range of physicochemical and thermodynamic properties. Of the MnPs tested, MnT4MPyP had the greatest effec

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22

Miao, Lu. "REDOX-REGULATED RELB-AR AXIS MEDIATES PROSTATE SPECIFIC ANTIGEN EXPRESSION: INSIGHT IN PROSTATE CANCER RESPONSE TO RADIATION THERAPY." UKnowledge, 2013. http://uknowledge.uky.edu/toxicology_etds/5.

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Although the prostate specific antigen (PSA) test is widely used in clinical settings for prostate cancer (PCa) diagnosis and post-treatment follow-up monitoring, false positive PSA test results, which contribute to over-diagnosis of PCa, and false negative results, which miss some patients with aggressive PCa, remain problems of clinical importance. Our study demonstrates that radiation therapy, which is widely used for treatment of localized PCa, generates TNF-α in tumor cells and stromal fibroblasts, redox dependently. Interestingly, TNF-α rapidly and transiently triggers the RelA-mediated

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23

Wryobeck, John M. "The role of fatigue, positive affect and negative affect in the reporting of quality of life in a group of radiation oncology patients." Virtual Press, 1998. http://liblink.bsu.edu/uhtbin/catkey/1074539.

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The use of quality of life instruments to evaluate the effect of cancer and its treatment on individuals has increased but the process by which the patient comes to make these quality of life evaluations has not been addressed. Earlier studies have shown the reporting of physical symptoms and the evaluation of one's health to be related to negative affect. The purpose of this study was to investigate whether the relationship between negative affect and the evaluation of ones health would remain the same in a group of cancer patients, when a major disease and treatment symptom, fatigue was cont

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24

Moretti, Luigi. "Molecular targeting for tumor radiosensitization: implications of apoptosis and autophagy signaling in combined anticancer therapy." Doctoral thesis, Universite Libre de Bruxelles, 2015. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/218736.

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The central hypothesis supporting the present work is that the effectiveness of radiation therapy for cancer is often limited due to defects in key apoptosis regulators, such as Bcl-2 family members, that contribute to cancer ability to evade apoptosis. One way to bypass this resistance to radiotherapy is to target cell death pathways, aiming to sensitize tumours to radiation and enhance the therapeutic ratio in cancer. To test this central hypothesis, we took a dual approach: one targeted apoptosis and the other targeted autophagy.<br>First, we focused on the apoptotic signaling. The Bcl-2 fa

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25

Jackson, Mark Richard. "The identification and validation of Auger electron-emitting radiopharmaceuticals targeting telomerase for cancer therapy." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:040d10f6-c69b-41d3-b73f-7c47c4053db2.

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Telomerase is expressed in the majority (>85%) of tumours but not in differentiated normal tissue. This enzyme catalyses the elongation of telomeres – a process critical for continued cell proliferation. Telomerase is a potential novel target for molecularly-targeted radiotherapy (mRT), due to its nuclear localization and expression profile. The radiolabelling of telomerase inhibitors may accelerate and enhance the cytotoxicity of such molecules, as a result of irradiation of the DNA. An oligonucleotide targeting telomerase RNA (hTR), shown to inhibit enzyme activity in vitro, was selected for

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26

Yates, Justin Yates. "Retrospective Dosimetric Comparison of MLC Defined Conformal Arc to Stereotactic Cone Plans for Single Fraction SRS on the Varian Edge (TM)." University of Toledo Health Science Campus / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=mco1525441068022458.

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27

Wu, Xuping. "Oesophageal Cancer – Novel Targets for Therapy : With focus on Hsp90, EGFR, LRIG, microtubule and telomerase." Doctoral thesis, Uppsala universitet, Enheten för onkologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-152614.

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Oesophageal cancer is a malignant and aggressive disease with very poor survival. The aim of this thesis was to evaluate novel therapeutic targets in oesophageal cancer. In paper I, Hsp90 was expressed in all 81 oesophageal cancer tissues and also in nine oesophageal cancer cell lines. A specific Hsp90 inhibitor, 17-AAG, could efficiently inhibit cell proliferation, cell survival and sensitise oesophageal cancer cells to gamma photon irradiation. By inhibition of Hsp90 using 17-AAG, EGFR- and IGF-1R-mediated signalling was downregulated. In paper II, tumour samples from 80 oesophageal cancer p

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28

Press, O. W., H. Li, H. Schoder, et al. "US Intergroup Trial of Response-Adapted Therapy for Stage III to IV Hodgkin Lymphoma Using Early Interim Fluorodeoxyglucose-Positron Emission Tomography Imaging: Southwest Oncology Group S0816." AMER SOC CLINICAL ONCOLOGY, 2016. http://hdl.handle.net/10150/616995.

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Purpose Four US National Clinical Trials Network components (Southwest Oncology Group, Cancer and Leukemia Group B/Alliance, Eastern Cooperative Oncology Group, and the AIDS Malignancy Consortium) conducted a phase II Intergroup clinical trial that used early interim fluorodeoxyglucose positron emission tomography (FDG-PET) imaging to determine the utility of response-adapted therapy for stage III to IV classic Hodgkin lymphoma. Patients and Methods The Southwest Oncology Group S0816 (Fludeoxyglucose F 18-PET/CT Imaging and Combination Chemotherapy With or Without Additional Chemotherapy and G

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Pirovano, Giacomo Maria. "TOPK as a novel determinant of radiosensitivity." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:a2b05e51-7f21-433f-8d28-51ac1a72a503.

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Radiotherapy is the use of ionising radiation to induce localised DNA damage to cancerous tissues, leading to cell death and disease control. In order to maximise tumour growth control and to limit damage of the healthy surrounding tissues and the consequent side effects for the patient, molecular determinants of tumour radioresistance are investigated as potential clinical targets. A high-throughput siRNA colony formation assay screen in HeLa cervical carcinoma cells previously published by our laboratory identified modulators of radiosensitivity. From the list CSF1R, EPHB2, GAK and TOPK, wer

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30

COSTA, GIULIO. "FROM THE PSYCHOLOGICAL ASSESSMENT TO THE SUPPORTIVE-EXPRESSIVE GROUP THERAPY FOR WOMEN WITH BREAST CANCER AND THEIR CAREGIVERS. A MULTI-METHOD DESIGN." Doctoral thesis, Università Cattolica del Sacro Cuore, 2008. http://hdl.handle.net/10280/330.

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Il presente lavoro di tesi si colloca all'interno di un più ampio programma di intervento clinico per pazienti oncologici. Facendo riferimento ad una cornice teorica basata sul modello relationship-centered care, l'obiettivo di tale programma di intervento è quello di ricercare ed attivare modalità di coping diadico funzionali per fronteggiare la malattia oncologica attraverso i quali si articola questa ricerca, vogliono esplorare tre modalità di coping e caregiving: individuale, diadico e di gruppo. Nel primo studio verranno indagate le strategie di coping e di adattamento interpersonale di d

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COSTA, GIULIO. "FROM THE PSYCHOLOGICAL ASSESSMENT TO THE SUPPORTIVE-EXPRESSIVE GROUP THERAPY FOR WOMEN WITH BREAST CANCER AND THEIR CAREGIVERS. A MULTI-METHOD DESIGN." Doctoral thesis, Università Cattolica del Sacro Cuore, 2008. http://hdl.handle.net/10280/330.

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Il presente lavoro di tesi si colloca all'interno di un più ampio programma di intervento clinico per pazienti oncologici. Facendo riferimento ad una cornice teorica basata sul modello relationship-centered care, l'obiettivo di tale programma di intervento è quello di ricercare ed attivare modalità di coping diadico funzionali per fronteggiare la malattia oncologica attraverso i quali si articola questa ricerca, vogliono esplorare tre modalità di coping e caregiving: individuale, diadico e di gruppo. Nel primo studio verranno indagate le strategie di coping e di adattamento interpersonale di d

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32

Bejarano, Buele Ana Isabel. "Comparison of Radiation Treatment Plans for Breast Cancer between 3D Conformal in Prone and Supine Positions in Contrast to VMAT and IMRT Supine Positions." University of Toledo Health Science Campus / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=mco1449854456.

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33

Angadi, Vrushali. "INVESTIGATING THE EFFICACY OF VOCAL FUNCTION EXERCISES IN IMPROVING VOCAL FUNCTION IN ADULTS IRRADIATED FOR LARYNGEAL CANCERS: A THREE PART DISSERTATION." UKnowledge, 2016. http://uknowledge.uky.edu/rehabsci_etds/33.

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Deterioration in voice quality following radiation therapy for the treatment of laryngeal cancers (LC) is well documented in literature. The majority of studies show that these voice problems are long term and in some cases permanent. Deterioration in voice quality, especially over a period of time could lead to significant communication difficulties in daily life or in some cases could even result in loss of profession. Despite the negative effects of radiation therapy on voice quality being well documented, few studies have focused on the efficacy of voice therapy in the irradiated LC popula

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Nieves, Christina Impoco. "Expressive Arts Intervention for the Adult Cancer Survivor in the Community Support Group Setting." Kent State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=kent1573897771394791.

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Chaplow, Zachary Lewis. "Effects of a Lifestyle Intervention on Change in Body Composition in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1523462399213986.

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Parkinson, Caprice S. "Camp for Childhood Cancer Survivors and Their Families: A Program Conceptualization." Wright State University Professional Psychology Program / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=wsupsych1342017721.

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Orvehed, Hiltunen Erik. "Robust optimization of radiotherapy treatment plans considering time structures of the delivery." Thesis, Uppsala universitet, Avdelningen för datalogi, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-355628.

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Cancer is the second largest mortal disease in Sweden, and high efforts are made to develop the treatment of cancer. One of the main treatment methods is radiotherapy, which uses ionizing radiation to damage the cancerous cells. This has the chance of stopping the cell reproduction, and the goal is to reduce the tumor and stop the tumor growth. The most common forms of radiotherapy uses external beams to irradiate the tumor. In intensity modulated radiotherapy, IMRT, the beam fluences are optimized to give a highly conformal dose, i.e. a dose distribution which is restricted to the tumor and h

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Pfister, Sophia Xiao. "The three methyls : the function and therapeutic potential of histone H3K36 trimethylation." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:83cfd649-b75c-49f6-b881-1c1e96cafb08.

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DNA is wrapped around proteins called histones, whose modification regulates numerous cellular processes. Therefore it is not surprising that mutations in the genes that modify the histones are frequently associated with human cancer. For example, mutations in SETD2, encoding the sole enzyme that catalyses histone H3 lysine 36 trimethylation (H3K36me3), occur frequently in multiple cancer types. This identifies H3K36me3 loss as an important event in cancer development, and also as a potential therapeutic target. This thesis investigates the following questions: (1) how does the loss of H3K36me

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Todd, Kimberly. "The effects of therapeutic reflexology on cervical cancer patients receiving radiation oncology." Thesis, 2012. http://hdl.handle.net/10210/5210.

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M.Tech.<br>The aim of this study was to determine the effects of the application of therapeutic reflexology as a complementary medicine, in women with cervical cancer who were receiving radiation therapy with curative intent. Therapeutic reflexology is a therapy that involves stimulating specific reflexes in the hands, feet, body and ears by applying pressure to these reflexes with the thumbs and fingers, using specific techniques. All the body’s organs, glands and other parts of the body are reflected in the feet, body, hands and ears can be stimulated by working over the skin surface with th

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Liu, Yilin. "Development and Optimization of Four-dimensional Magnetic Resonance Imaging (4D-MRI) for Radiation Therapy." Diss., 2016. http://hdl.handle.net/10161/12267.

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<p>A tenet of modern radiotherapy (RT) is to identify the treatment target accurately, following which the high-dose treatment volume may be expanded into the surrounding tissues in order to create the clinical and planning target volumes. Respiratory motion can induce errors in target volume delineation and dose delivery in radiation therapy for thoracic and abdominal cancers. Historically, radiotherapy treatment planning in the thoracic and abdominal regions has used 2D or 3D images acquired under uncoached free-breathing conditions, irrespective of whether the target tumor is moving or not.

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Li, Taoran. "Towards the Clinical Implementation of Online Adaptive Radiation Therapy for Prostate Cancer." Diss., 2013. http://hdl.handle.net/10161/7154.

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<p>The online adaptive radiation therapy for prostate cancer based on re-optimization has been shown to provide better daily target coverage through the treatment course, especially in treatment sessions with large anatomical deformation. However, the clinical implementation of such technique is still limited primarily due to two major challenges: the low efficiency of re-optimization and the lack of online quality assurance technique to verify delivery accuracy. This project aims at developing new techniques and understandings to address these two challenges. </p><p>The study was based on ret

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McGurk, Ross. "Consensus Segmentation for Positron Emission Tomography: Development and Applications in Radiation Therapy." Diss., 2013. http://hdl.handle.net/10161/7178.

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<p>The use of positron emission tomography (PET) in radiation therapy has continued to grow, especially since the development of combined computed tomography (CT) and PET imaging system in the early 1990s. Today, the biggest use of PET-CT is in oncology, where a glucose analog radiotracer is rapidly incorporated into the metabolic pathways of a variety of cancers. Images representing the in-vivo distribution of this radiotracer are used for the staging, delineation and assessment of treatment response of patients undergoing chemotherapy or radiation therapy. While PET offers the ability to pro

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Zhang, You. "Optimization of Image Guided Radiation Therapy for Lung Cancer Using Limited-angle Projections." Diss., 2015. http://hdl.handle.net/10161/9856.

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<p>The developments of highly conformal and precise radiation therapy techniques promote the necessity of more accurate treatment target localization and tracking. On-board imaging techniques, especially the x-ray based techniques, have found a great popularity nowadays for on-board target localization and tracking. With an objective to improve the accuracy of on-board imaging for lung cancer patients, the dissertation work focuses on the investigations of using limited-angle on-board x-ray projections for image guidance. The limited-angle acquisition enables scan time and imaging dose reducti

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Belley, Matthew David. "Monte Carlo Analysis and Physics Characterization of a Novel Nanoparticle Detector for Medical and Micro-dosimetry Applications." Diss., 2015. http://hdl.handle.net/10161/11320.

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<p>The outcomes for both (i) radiation therapy and (ii) preclinical small animal radio- biology studies are dependent on the delivery of a known quantity of radiation to a speciﬁc and intentional location. Adverse eﬀects can result from these procedures if the dose to the target is too high or low, and can also result from an incorrect spatial distribution in which nearby normal healthy tissue can be undesirably damaged by poor radiation delivery techniques. Thus, in mice and humans alike, the spatial dose distributions from radiation sources should be well characterized in terms of the absolu

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Alshammari, Meshari Turki. "Treatment planning and dosimetric verification of cyberknife prostate SBRT (stereotactic body radiation therapy) on an MR-based 3D prostate model imaging insert in a pelvis phantom." Thesis, 2016. https://hdl.handle.net/2144/16805.

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Purpose of this study was to validate a novel CyberKnife stereotactic body radiotherapy (SBRT) treatment planning on an MRI-based 3D prostate model insert in an anthropomorphic pelvis phantom using Gafchromic EBT3 films to perform dosimetric measurements. The methodology of this study is based on a pelvis phantom and a physical printed 3D model of the prostate with dominant intra-prostatic-lesion and surrounding organs at risk segmented from a patient MR images. Cyberknife prostate treatment planning was performed to have at least 95% the planning target volumes (PTV: prostate expanded with ma

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Borges, Cecília. "Impact of using different radiation therapy techniques in breat cancer: contralateral breast dose." Doctoral thesis, 2014. http://hdl.handle.net/10362/14235.

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RESUMO: O cancro de mama e o mais frequente diagnoticado a indiv duos do sexo feminino. O conhecimento cientifico e a tecnologia tem permitido a cria ção de muitas e diferentes estrat egias para tratar esta patologia. A Radioterapia (RT) est a entre as diretrizes atuais para a maioria dos tratamentos de cancro de mama. No entanto, a radia ção e como uma arma de dois canos: apesar de tratar, pode ser indutora de neoplasias secund arias. A mama contralateral (CLB) e um orgão susceptivel de absorver doses com o tratamento da outra mama, potenciando o risco de desenvolver um tumor secund ario

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Komen, Ahmed Abdi. "A retrospective study of advanced carcinoma of the cervix treated with a hypofractionated radiation therapy protocol at the department of radiation oncology, University of Witwatersrand, Johannesburg, South Africa." Thesis, 2014. http://hdl.handle.net/10539/17380.

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A dissertation submitted to the Faculty of Health Sciences, University of the Witwatersrand, in partial fulfilment of the requirements for the degree of Master of Medicine in Radiation Oncology. May, 2014<br>Background: Carcinoma of the cervix is a common cancer among women in developing countries and with the rising HIV environment the burden of cervical cancer might be even greater, stretching the limited resources even further. This retrospective descriptive study evaluates the potential of the hypofractionated departmental protocol for stage 3b carcinoma of the cervix in terms of toxic

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Soares, Daniela Sofia Neves. "Guide for ferrets lymphoma." Master's thesis, 2015. http://hdl.handle.net/10400.26/16790.

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Ferrets popularity as pets is increasing in North America and Europe and appear more frequently in veterinary practice. Therefore, it is important to study this specie in order to provide advanced medical care. After insulinoma and adrenocortical neoplasia, lymphoma is the third more common neoplasia in domestic ferrets, and this condition appears to be increasing in frequency. Lymphoma can be described as a proliferation of neoplastic lymphoid cells, and can occur in ferrets of all ages and in practically all organ systems. Despite various theories, the exact etiology of lymphoma remains unk

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Judd-Glossy, Laura Elizabeth. "The impact of a blended cognitive remediation and cognitive behavioral group therapy for pediatric oncology survivors : a mixed methods approach." 2013. http://hdl.handle.net/2152/21161.

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Advances in cancer treatment have led to a significant increase in the number of pediatric oncology survivors. These survivors often have late effects in their cognitive, academic, executive, and psychological functioning subsequent to their chemotherapy and radiation treatment. In particular, executive functioning (EF), which is crucial for cognitive and academic functioning, has been recognized as an area that is impacted by treatment. Several studies have described cognitive remediation programs that seek to improve EF skills in pediatric oncology survivors. Although these programs have led

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Roper, Justin R. "On-board Single Photon Emission Computed Tomography (SPECT) for Biological Target Localization." Diss., 2010. http://hdl.handle.net/10161/2986.

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<p>On-board imaging is useful for guiding radiation to patients in the treatment position; however, current treatment-room imaging modalities are not sensitive to physiology - features that may differentiate tumor from nearby tissue or identify biological targets, e.g., hypoxia, high tumor burden, or increased proliferation. Single photon emission computed tomography (SPECT) is sensitive to physiology. We propose on-board SPECT for biological target localization.</p><p>Localization performance was studied in computer-simulated and scanner-acquired parallel-hole SPECT images. Numerical obser

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