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1

Vyborny, C., P. Bunch, H. Chotas, J. Dobbins, L. Niklason, and C. Schaefer-Prokop. "Image Quality in Chest Radiography: Abstract." Journal of the ICRU 3, no. 2 (2003): 13. http://dx.doi.org/10.1093/jicru_3.2.13.

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Image quality in chest radiography is an important, but complex, subject. The complicated anatomy of the chest, as well as the various ways that chest disease may manifest itself, require careful consideration of radiographic technique. The manner in which human observers deal with the complexity of chest images adds further dimensions to image analysis that are not found in other radiography examinations. This report describes many issues that are related to the quality of chest radiographic images. In so doing, it relies upon the very extensive literature on this topic, a topic that has been one of the most thoroughly studied in all of radiography. Strategies that are generally agreed to improve the quality of chest radiographs are described, as are approaches to the assessment of image quality.
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Abbeyquaye, D., S. Inkoom, N. B. Hammond, J. J. Fletcher, and B. O. Botwe. "PATIENT DOSE ASSESSMENT AND OPTIMISATION OF PELVIC RADIOGRAPHY WITH COMPUTED RADIOGRAPHY SYSTEMS." Radiation Protection Dosimetry 195, no. 1 (2021): 41–49. http://dx.doi.org/10.1093/rpd/ncab111.

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Abstract Digital radiography systems can reduce radiation dose, this capability was harnessed to explore dose and image quality (IQ) optimisation strategies. Entrance surface dose (ESD), effective dose (ED) and organ doses were determined by the indirect method for patients undergoing pelvic anteroposterior X-ray examinations with computed radiography systems. The IQ of patients’ radiographs was assessed in terms of signal-to-noise ratio (SNR). An anthropomorphic phantom was exposed with varying tube potential (kVp), tube current-time product (mAs), and focus-to-detector distance (FDD) to determine phantom-entrance dose for the optimisation studies. SNR of each phantom radiograph was determined. Patients’ mean ESD of 2.38 ± 0.60 mGy, ED of 0.25 ± 0.07 mSv and SNR of 8.5 ± 2.2 were obtained. After optimisation, entrance dose was reduced by 29.2% with 5 cm increment in FDD, and 5 kVp reduction in tube potential. kVp and/or mAs reduction with an increment in FDD reduced entrance dose without adversely compromising radiographic-IQ.
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Nalawade, Triveni, Siham Al Shereiqi, Raqiya Al Nahdi, et al. "A RETROSPECTIVE CLINICAL AUDIT OF QUALITY OF INDIRECT DIGITAL INTRAORAL RADIOGRAPHS TAKEN BY STUDENTS AND DENTAL ASSISTANTS IN AN UNDERGRADUATE DENTAL CLINIC." Quality : Jurnal Kesehatan 18, no. 1 (2024): 19–26. http://dx.doi.org/10.36082/qjk.v18i1.1504.

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Background: Intraoral radiographs are essential diagnostic tools in dentistry. Ensuring their quality is crucial for accurate diagnosis and treatment planning. This study compared the quality of radiographs produced by undergraduate dental students and qualified dental assistants to identify common errors and assess improvements following feedback and interventions. Methods: This retrospective, observational study compared the quality of digital bitewing and periapical radiographs taken by students and assistants across two audit cycles, with feedback provided between cycles. The radiographs were assessed using a modified quality assessment scale based on the Faculty of General Dental Practice (FGDP, UK) guidelines. Data were collected from the radiology imaging software, and a total of 100 intraoral digital radiographs were analyzed for each group in both cycles. Results: Initially, radiographs from both groups had issues, primarily positioning errors. After providing feedback and additional training, significant improvements were observed from Cycle 1 to Cycle 2. Dental assistants had a higher percentage of acceptable periapical radiographs, while students excelled in bitewing radiographs. Both groups demonstrated marked improvements, reflecting the effectiveness of the interventions. Conclusions: Continuous training, feedback, and quality assurance measures are vital for improving radiograph quality. A multifaceted approach, including updated equipment and adherence to quality control protocols, can significantly enhance patient care. The study highlights the importance of regular calibration and training for dental professionals to maintain high standards in radiographic practices. Further research is recommended to identify additional strategies for improving radiographic quality.
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Adams Hilgert, Eduarda, Heraldo Luis Dias da Silveira, Mariana Boessio Vizzotto, Priscila Fernanda Da Silveira Tiecher, and Nádia Assein Arús. "A experiência clínica influencia na capacidade de alunos para o diagnóstico de alterações dentoalveolares utilizando exames radiográficos intraorais?" Revista da Faculdade de Odontologia de Porto Alegre 61, no. 2 (2020): 7–12. http://dx.doi.org/10.22456/2177-0018.101545.

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Mastery of interpretation of radiographic images is a contributing factor in correct diagnosis of conditions affecting the dentoalveolar apparatus. It is therefore essential that students’ perfect these skills while studying for their degrees. Once they embark upon their professional careers outside of the university setting, it is expected that the theoretical knowledge and clinical experience accumulated during the course of their studies will have led to improved diagnostic performance. Objective: The objective of this study was to evaluate diagnoses made using intraoral radiographs by undergraduate students at a School of Dentistry in the South of Brazil, before and after their introduction to clinical practice. Materials and methods: Diagnoses made during the second (T0) and fourth (T1) years of the undergraduate course in dentistry using interproximal and periapical radiographs were analyzed. Descriptive statistics were calculated and the McNemar test was used to compare answers at T0 and T1. Results: Fifteen students answered questionnaires at both T0 and T1. The overall percentage of correct answers was 70.5% at T0 and 61.6% at T1, with a significant difference (p = 0.024). Discussion: This study highlights the need for educational strategies that improve diagnostic competence during undergraduate clinical activities, since radiographic examinations are essential in all areas of dentistry. Conclusions: Therefore, it was concluded that the rate of correct diagnosis of dentoalveolar disorders by intraoral radiography decreased significantly after the initial years of clinical training.
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Heffernan, Courtney, James Barrie, Alexander Doroshenko, et al. "Prompt recognition of infectious pulmonary tuberculosis is critical to achieving elimination goals: a retrospective cohort study." BMJ Open Respiratory Research 7, no. 1 (2020): e000521. http://dx.doi.org/10.1136/bmjresp-2019-000521.

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IntroductionAll pulmonary tuberculosis (PTB) cases are presumed to be infectious to some degree. This spectrum of infectiousness is independently described by both the acid-fast bacilli smear and radiographic findings. Smear-positive patients with chest radiographic findings that are typical for adult-type PTB are believed to be most infectious.HypothesisCharacterisation of the presumed most infectious PTB case is possible by reference to readily available clinical features and laboratory results.MethodsRetrospective cohort study of adult, culture-positive PTB cases (151 smear-positive; 162 smear-negative) diagnosed between 1 January 2013 and 30 April 2017 in Canada. We describe cases according to demographic, clinical and laboratory features. We use multivariable multinomial logistic regression to estimate the relative risk ratio (RRR) with 95% CI of features associated with an outcome of smear-positive PTB, characterised by ‘typical’ chest radiograph findings.ResultsBeing Canadian-born, symptomatic, having a subacute duration of symptoms and broad-spectrum antibiotic prescriptions were all more commonly associated with smear-positive than smear-negative disease (36% vs 20%; 95% vs 63%; 88% vs 54%; and 59% vs 28%, respectively). After combining smear status and radiographic features, we show that smear-positive patients with typical chest radiographs were younger, had a longer duration of symptoms (RRR 2.41; 95% CI 1.01 to 5.74 and 2.93; 95% CI 1.20 to 7.11, respectively) and were less likely to be foreign-born, or have a moderate to high-risk factor for reactivation (RRR 0.40; 95% CI 0.17 to 0.92 and 0.18; 95% CI 0.04 to 0.71, respectively) compared with smear-negative patients with atypical chest radiograph findings.ConclusionA clear picture of the presumed most infectious PTB case emerges from available historical and laboratory information; vigilance for this presentation by front-line providers will support elimination strategies aimed at reducing transmission.
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Izal, Maria, Almudena López-López, Ignacio Montorio, and José Luis González. "Discrepancy between Radiographic Damage and Functional Disability in Elderly People with Osteoarthritis: The Role of Pain Coping Strategies." Spanish journal of psychology 13, no. 2 (2010): 875–85. http://dx.doi.org/10.1017/s1138741600002523.

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The aim of this study is twofold. First, to assess the level of agreement between radiographic damage and functional disability in older people with osteoarthritis. And second, to assess the role of coping skills and sensory pain parameters as sources of disagreement between these variables. To achieve this objective we assess, in a sample of 104 older people with osteoarthritis, the following variables: functional capacity, radiographic damage, pain coping strategies, pain intensity, pain frequency and pain duration. The results show a non-linear relationship between radiographic damage and functional disability, modified by the levels of the two variables. There was maximum agreement between low levels of radiographic damage and of functional impairment, whilst agreement decreased for moderate and high levels of radiographic damage. Certain coping strategies may help to explain this disparity.
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Rho, Jinhyung, Sung-Min Shin, Kyoungsun Jhang, et al. "Deep learning-based diagnosis of feline hypertrophic cardiomyopathy." PLOS ONE 18, no. 2 (2023): e0280438. http://dx.doi.org/10.1371/journal.pone.0280438.

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Feline hypertrophic cardiomyopathy (HCM) is a common heart disease affecting 10–15% of all cats. Cats with HCM exhibit breathing difficulties, lethargy, and heart murmur; furthermore, feline HCM can also result in sudden death. Among various methods and indices, radiography and ultrasound are the gold standards in the diagnosis of feline HCM. However, only 75% accuracy has been achieved using radiography alone. Therefore, we trained five residual architectures (ResNet50V2, ResNet152, InceptionResNetV2, MobileNetV2, and Xception) using 231 ventrodorsal radiographic images of cats (143 HCM and 88 normal) and investigated the optimal architecture for diagnosing feline HCM through radiography. To ensure the generalizability of the data, the x-ray images were obtained from 5 independent institutions. In addition, 42 images were used in the test. The test data were divided into two; 22 radiographic images were used in prediction analysis and 20 radiographic images of cats were used in the evaluation of the peeking phenomenon and the voting strategy. As a result, all models showed > 90% accuracy; Resnet50V2: 95.45%; Resnet152: 95.45; InceptionResNetV2: 95.45%; MobileNetV2: 95.45% and Xception: 95.45. In addition, two voting strategies were applied to the five CNN models; softmax and majority voting. As a result, the softmax voting strategy achieved 95% accuracy in combined test data. Our findings demonstrate that an automated deep-learning system using a residual architecture can assist veterinary radiologists in screening HCM.
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ÇOLAK, Sefa, Ahmet ALTAN, Nihat AKBULUT, and Halenur ALTAN. "Radiographic Features and Treatment Strategies of Impacted Maxillary Canines." Cumhuriyet Dental Journal 23, no. 1 (2020): 31–36. http://dx.doi.org/10.7126/cumudj.657384.

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Lo, Grace H., Michael J. Richard, Timothy E. McAlindon, et al. "Increased risk of incident knee osteoarthritis in those with greater work-related physical activity." Occupational and Environmental Medicine 79, no. 8 (2022): 543–49. http://dx.doi.org/10.1136/oemed-2022-108212.

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ObjectiveOccupations involving greater physical activity may increase risk for knee osteoarthritis (OA). Existing studies have not evaluated work-related physical activity before OA onset. Hence, we aimed to evaluate the association between work-related physical activity and knee OA incidence.MethodsWe performed a person-based longitudinal study using Osteoarthritis Initiative (OAI) data among people who volunteered or worked for pay without baseline radiographic knee OA or knee pain. Bilateral knee radiographs were obtained at baseline and annual follow-ups. We defined radiographic OA as Kellgren-Lawrence grade ≥2. Questions from the Physical Activity Scale for the Elderly at baseline and annual OAI visits provided information about work-related physical activity level and hours. We performed logistic regression with work-related physical activity level (mainly sitting, standing and some walking, walking while handling some materials) and hours as predictors. The outcome was incident person-based radiographic OA within the ensuing 12 months, over 48 months.ResultsAmong 951 participants (2819 observations), higher work-related physical activity levels had greater adjusted ORs for incident radiographic OA (people with jobs with standing and some walking: 1.11 (0.60–2.08), and walking while handling some materials: 1.90 (1.03–3.52), when compared with those with mainly sitting work-related activity). There was no association between number of hours worked and incident radiographic OA.ConclusionsPeople performing work that require walking while handling some materials have greater odds of incident knee OA than those with jobs mostly involving sitting. Strategies are needed to mitigate risk factors predisposing them to radiographic OA.
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Arfat, M., Tarana Beg, and Afifa Haq. "Challenges were faced during radiography of pregnant women." International Journal Of Community Medicine And Public Health 11, no. 9 (2024): 3735–37. http://dx.doi.org/10.18203/2394-6040.ijcmph20242582.

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Radiography of pregnant patients poses significant challenges to radiographers due to the need to balance diagnostic requirements with the safety of the developing foetus. This article explores the challenges faced by radiographers when conducting radiographic procedures on pregnant women and their foetus and discusses strategies employed to minimize radiation exposure. Key challenges include the risk of foetal radiation exposure, timing of examination, proper positioning of the patient and patient anxiety. Strategies such as radiation shielding, collimation, low-dose techniques and alternative imaging modalities are crucial for minimizing radiation exposure while obtaining diagnostic information. Clear communication between radiographers and patient is essential to ensure the safety and well-being of both the mother and the foetus during radiographic procedure. Radiographers knows the dangers of radiation exposure to fetal health. Now days, diagnostic imaging of pregnant women is increasing. X-ray risks depending on the gestational age of the pregnancy, and other potential health effects. In addition, ethical issues have been considered by improving overall communication to minimize unnecessary radiation exposure to pregnant women and fetuses.
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Brandt, Lena L. N., Hendrik Schulze-Koops, Thomas Hügle, Michael J. Nissen, Johannes von Kempis, and Ruediger B. Mueller. "Radiographic Progression in Patients with Rheumatoid Arthritis in Clinical Remission or Low Disease Activity: Results from a Swiss National Registry (SCQM)." Journal of Clinical Medicine 13, no. 23 (2024): 7424. https://doi.org/10.3390/jcm13237424.

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Background/Objectives: The therapeutic aim for rheumatoid arthritis (RA) is to control disease activity and prevent radiographic progression. Various clinical scores are used to assess disease activity in RA patients. The DAS 28 score can define states of low disease activity (LDA) and remission. Despite achieving LDA or remission, radiographic progression may, nevertheless, occur. However, the rates and frequency of this occurrence have not been analyzed in detail. (1) To characterize radiographic progression in patients with persistent DAS 28-defined LDA or remission. (2) Analyze the potential benefits of modifying therapeutic strategies in response to observed radiographic progression in patients with persistent LDA or remission. Methods: An analysis was conducted on RA patients enrolled in the SCQM (Swiss Clinical Quality Management) cohort. Persistent LDA or remission was defined as DAS 28 ≤ 3.2 or < 2.6, respectively, recorded at two consecutive follow-up time points. Inclusion criteria involved patients with a minimum of two sets of radiographs taken during these LDA and/or remission periods. Radiographic progression was measured using the Ratingen score, a numerical scale ranging from 0 to 190, which quantifies joint erosions. Repair was defined as a decrease in the Ratingen score >5 points/year, while progression was characterized by an increase of >1, >2, or >5 points change in the Ratingen score within a one-year timeframe. Results: Among 10′141 RA patients, there were 1′447 episodes of remission and 2′614 episodes of LDA, with two sets of X-rays available for assessment during these episodes. The rates of radiographic progression (>5 points change in the Ratingen score per year) were 11.2% for LDA and 8.8% for remission. Therapeutic adaptations were made in 7.0% of patients in remission and 12.9% of patients in LDA following radiographic progression. After radiographic progression despite LDA, loss of LDA was observed in 19% of patients with treatment intensification versus in 8.5% under continued treatment during follow-up within 36 months. Conclusions: We report a considerable rate of radiographic progression occurring in RA patients with LDA or clinical remission. Notwithstanding minor radiographic progression, maintaining therapeutic continuity seemed more favorable than altering the therapeutic regimen.
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Bakker, M. F., J. W. G. Jacobs, P. M. J. Welsing, et al. "Early clinical response to treatment predicts 5-year outcome in RA patients: follow-up results from the CAMERA study." Annals of the Rheumatic Diseases 70, no. 6 (2011): 1099–103. http://dx.doi.org/10.1136/ard.2010.137943.

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ObjectiveTo investigate the long-term effects of the tight control (TC) and conventional (CT) methotrexate-based strategies of the Computer Assisted Management in Early Rheumatoid Arthritis trial in early rheumatoid arthritis and evaluate the predictive value of an early response to treatment.MethodsClinical and radiographic 5-year outcome was compared between initial strategies. Patients were classified according to the EULAR response criteria. The prognostic value of early response to treatment in addition to established predictors was analysed by multiple linear regression analyses.Results5 years of data were available for 205 of 299 patients, with no indication for selective drop-out. At 5 years there was no longer any significant difference for clinical and radiographic outcomes between treatment strategies applied during the first 2 years. Good-responders had a mean disease activity score of 2.39 (1.2) and median yearly radiographic progression rate of 0.6 (0.0 to 2.2) at 5 years; significantly lower (both p<0.02) when compared to moderate- and non-responders. Multiple regression analysis showed that early response to treatment is an independent predictor of 5-year outcome, irrespective of treatment strategy.ConclusionsThe difference in disease activity between treatment strategies disappeared over the years. Good-response to treatment independently predicts significantly better 5-year clinical and radiographic outcome. The TC principle probably should be continued in the long-term.
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Hoy, John F., Farhan Ahmad, Mark S. Cohen, Robert W. Wysocki, John J. Fernandez, and Xavier C. Simcock. "Progression of arthritis after four-corner fusion in patients with calcium pyrophosphate deposition disease: a case series of eleven patients." Exploration of Musculoskeletal Diseases 2, no. 4 (2024): 256–63. http://dx.doi.org/10.37349/emd.2024.00053.

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Aim: The purpose of this study is to evaluate outcomes and radiographic progression of wrist arthritis after four-corner fusion (4CF) in patients with evidence of calcium pyrophosphate deposition disease (CPPD). The insights derived from this study are expected to improve the understanding of 4CF outcomes in the presence of CPPD, guiding clinical decisions, and management strategies. Methods: 11 patients with prior 4CF and evidence of CPPD were available for prospective follow-up and imaging, with a mean follow-up time of 5 years. Range of motion measurements, radiographs, and outcome data were collected at the follow-up visit and prior data and imaging were reviewed retrospectively. The chronological progression of arthritis was evaluated on standard three-view wrist radiographs using the Larsen scale. Results: All participants (11/11) deemed their wrist fusion a success, with an average satisfaction score of 8.8 out of 10.73% (8/11) patients were able to return to their original occupation after the procedure. The mean flexion of the affected wrist preoperatively was 43 degrees (SD: ±12 degrees) and 41 degrees (SD: ±7 degrees) at the final follow-up. The mean extension of the affected wrist was 35 degrees (SD: ±8 degrees) preoperatively and 40 degrees (SD: ±12 degrees) at the final follow-up. Radiographic analysis showed that 82% (9/11) of patients displayed progression of arthritis as per the Larsen scale by the final follow-up. All patients that showed radiographic progression had involvement of the radiolunate (RL) articulation, which is classically persevered in non-inflammatory wrist arthritis. Conclusions: Scaphoid excision with 4CF is a promising surgical option for managing CPPD-related wrist arthritis, offering significant functional improvements, motion preservation, and high patient satisfaction. However, it does not halt radiographic progression of arthritis for the majority of patients at a mean prospective long-term follow-up of 5 years.
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Fragoulis, George E., and Stefan Siebert. "Treatment strategies in axial spondyloarthritis: what, when and how?" Rheumatology 59, Supplement_4 (2020): iv79—iv89. http://dx.doi.org/10.1093/rheumatology/keaa435.

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Abstract There have been major advances in the management of axial spondyloarthritis (axSpA) with the introduction of effective biologic agents targeting TNF and IL-17A. Clinicians now have more choice but, despite treatment recommendations, are still faced with significant uncertainty when deciding on the optimal treatment strategy for an individual patient in clinical practice. Management of axSpA typically requires both non-pharmacological and pharmacological interventions. NSAIDs remain the first line drug therapies for axSpA with proven efficacy for symptomatic management but uncertainty remains regarding their optimal long-term use relating to radiographic progression and safety in axSpA. To-date there are no head-to-head trials of biologics in axSpA. Clinicians need to consider other factors, including extra-articular manifestations, comorbidities, safety and radiographic progression when deciding on which biologic to recommend for an individual patient. This article will explore the evidence relating to these factors and highlight areas of unmet need.
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FITZGERALD, OLIVER, CHRISTOPHER T. RITCHLIN, and PHILIP J. MEASE. "Biomarkers of Radiographic Progression in Psoriatic Arthritis: A Report from the GRAPPA 2011 Annual Meeting." Journal of Rheumatology 39, no. 11 (2012): 2189–92. http://dx.doi.org/10.3899/jrheum.120820.

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Clinical markers of radiographic progression have been studied in patients with psoriatic arthritis (PsA), and results have clearly confirmed the progression of radiographic damage over a 2-year period. Biomarkers of radiographic progression damage (erosion and new bone formation) have also been identified as a critical research issue in these patients. At the 2011 annual meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), members discussed development of a pivotal observational study (PsA Biodam study) to determine the validity of several soluble biomarkers in predicting structural damage in patients with PsA receiving standard therapies. Specific protocol issues discussed were the inclusion criteria, selection of candidate biomarkers, timing of sample collection, the primary radiographic outcome measure, radiographic scoring methods, possible substudies, and funding strategies.
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Sadat, Umar. "Radiographic Contrast-Media-Induced Acute Kidney Injury: Pathophysiology and Prophylactic Strategies." ISRN Radiology 2013 (September 16, 2013): 1–21. http://dx.doi.org/10.5402/2013/496438.

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Contrast-induced acute kidney injury (CI-AKI) is one of the most widely discussed and debated topics in cardiovascular medicine. With increasing number of contrast-media- (CM-) enhanced imaging studies being performed and growing octogenarian population with significant comorbidities, incidence of CI-AKI remains high. In this review, pathophysiology of CI-AKI, its relationship with different types of CM, role of serum and urinary biomarkers for diagnosing CI-AKI, and various prophylactic strategies used for nephroprotection against CI-AKI are discussed in detail.
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Sharmeen Aslam, Mubasshra Iqbal, Muhammad Shaheryar, and Muhammad Arslan. "Investigating the Efficacy of Early Intervention Strategies in Preventing Joint Damage in High Risk Rheumatoid Arthritis Patients." Indus Journal of Bioscience Research 3, no. 4 (2025): 627–32. https://doi.org/10.70749/ijbr.v3i4.1033.

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Objectives: To evaluate the clinical and radiographic efficacy of early DMARD initiation in preventing joint damage among high-risk RA patients. Study Settings: Rheumatology Department, tertiary care hospital. Duration of Study: 12 months. Data Collection: This prospective randomized controlled trial included 256 patients with newly diagnosed high-risk RA, stratified into Early (DMARDs within 6 weeks of symptom onset) and Delayed (DMARDs after 6 months) intervention groups. Patients were assessed using DAS28, HAQ-DI, and Sharp/van der Heijde scores over 12 months. ACR20 response and radiographic progression were primary outcomes. Results:The Early group showed significantly greater clinical improvement and joint preservation. ACR20 was achieved in 55.5% of the Early group vs. 28.1% in the Delayed group (p = 0.0000). Mean reduction in DAS28 score was greater in the Early group (from 5.58 to 3.56) than in the Delayed group (to 4.57; p = 0.0000). Radiographic progression was significantly lower in the Early group, with a Sharp score increase of 0.49 vs. 2.69 in the Delayed group (p = 0.0000). Conclusion: Early intervention with DMARDs significantly improves clinical outcomes and prevents joint damage in high-risk RA patients.
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Cotter, Jillian, Sonja Ziniel, Matthew Weber, Lilliam Ambroggio, and Sarah Parker. "Clinician Survey about Antibiotic Prescribing for Children without Definitive Radiographic Pneumonia." Journal of the Pediatric Infectious Diseases Society 13, Supplement_3 (2024): S5—S6. https://doi.org/10.1093/jpids/piae088.010.

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Abstract Corresponding Author: Jillian M. Cotter, MD, MSCS; Assistant Professor, Department of Pediatrics, Section of Hospital Medicine; Children’s Hospital Colorado and University of Colorado School of Medicine; 13123 E 16th Ave, Box B302, Aurora, CO 80045; jillian.cotter@childrenscolorado.org; 720-777-5241 Alternate Corresponding Author: Matthew J. Weber, MPH, Department of Pediatrics, Section of Infectious Diseases; Children’s Hospital Colorado and University of Colorado School of Medicine; 13123 E 16th Ave, Box B055, Aurora, CO 80045; matthew.weber@childrenscolorado.org; 720-777-8811 Conflicts of interest/disclosures: Drs. Cotter and Ambroggio receive grant support from Pfizer Inc for a study unrelated to this manuscript. The authors have no other conflicts of interest or financial disclosures. Funding sources: This was funded by an internal Children’s Hospital of Colorado Clinical Effectiveness and Patient Safety grant. Background Antibiotics are commonly overused in pediatric community acquired pneumonia (CAP). While children without definitive evidence of pneumonia on chest radiograph (CXR) are less likely to have bacterial CAP, many still receive antibiotics. We aimed to 1) evaluate the proportion of patients treated for bacterial CAP who had non-radiographic CAP (i.e., no definitive radiographic evidence of pneumonia, including equivocal or non-focal CXRs), and 2) understand clinician certainty and factors that influenced the decision to prescribe antibiotics for children with non-radiographic CAP. Methods This was a cross-sectional study of children who were treated for CAP (i.e., received at least one antibiotic dose or prescription) and were discharged from the emergency department (ED) or hospitalized at four affiliated children’s hospitals from 5/2022-11/2022. Children were classified as radiographic CAP (e.g., “focal consolidation”, “pneumonia”) vs. non-radiographic CAP (e.g., equivocal CXR – “atelectasis vs pneumonia, likely atelectasis but cannot rule out pneumonia” or non-focal – “peribronchial thickening without focality, normal CXR, airway disease”) based on the radiology report. Electronic surveys, designed to understand near real-time decision making in non-radiographic CAP, were sent to ED and inpatient clinicians who treated children with non-radiographic CAP in the preceding 48 hours. Chi-squared, Fisher’s exact and Student t-tests compared findings between various subgroups. Results Of 874 patients treated for CAP, 30% had non-radiographic CAP (11% non-focal and 19% equivocal CXRs). Among children with non-radiographic CAP, 60% were <5 years old, 56% hospitalized, and 86% received a full antibiotic course (Table 1). Receipt of a full antibiotic course did not differ between those with non-focal vs. equivocal CXRs (p>0.05). Among 177 completed clinician surveys (53% response rate), 60% were very or mostly certain about the diagnosis. Factors that most influenced antibiotic prescribing in non-radiographic CAP were CXR results (including 47% of clinicians who treated non-focal CXRs), other diagnostics, and physical exam findings (Figure 1). For patients already started on antibiotics by prior clinicians, 93% felt this prior decision strongly or somewhat influenced their decision to continue therapy. Conclusion Nearly a third of children treated for bacterial CAP had non-radiographic CAP, and 1 in 10 had a non-focal CXR. Most went onto receive a full antibiotic course. This suggests that non-radiographic CAP is an important target for antibiotic stewardship. We identified potential barriers (e.g., clinician certainty) and facilitators of future interventions. Specifically, targeted education regarding CXR interpretation and strategies to address antibiotic momentum may help reduce antibiotic overuse. Table 1. Characteristics of Children Treated for Non-Radiographic CAP Figure 1. Factors Influencing Decision to Prescribe Antibiotics for Non-Radiographic CAP
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Willis, C. E. "Strategies for dose reduction in ordinary radiographic examinations using CR and DR." Pediatric Radiology 34, S3 (2004): S196—S200. http://dx.doi.org/10.1007/s00247-004-1269-6.

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Heimes, Diana, Nicolas Alexander Mark, Robert Kuchen, et al. "Evaluation of Medication-Related Osteonecrosis of the Jaw (MRONJ) in Terms of Staging and Treatment Strategies by Dental Students at Different Educational Levels." Medicina 59, no. 2 (2023): 252. http://dx.doi.org/10.3390/medicina59020252.

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Background: The role of medication-related osteonecrosis of the jaw (MRONJ) as a dento-maxillo-facial pathology is becoming increasingly important due to its growing prevalence. The success of preventive and therapeutic measures relies mainly on the dentist’s ability to correctly diagnose the disease. Methods: The aim of this study was to evaluate the skills of dental students of different educational levels in choosing the correct stage, diagnostics, and treatment option for MRONJ based on clinical and radiographic imaging (panoramic radiograph, CBCT). The study was designed as a cross-sectional cohort study. Twenty dental students were asked to complete a questionnaire in their third and fifth year of studies in which they had to correctly stage the disease, choose the radiological diagnostics and recommend the treatment. The control group contained experienced oral and maxillofacial surgeons. Results: With an overall performance of 59% (third year: 145.2/248 points; fifth year: 145.3/248 points), no statistically significant difference between the educational levels could be observed. The classification based on CBCT imaging was significantly more often correct compared to panoramic radiographs (p < 0.001). Conclusions: This study highlights students’ lack of knowledge in staging, diagnostics, and treatment of MRONJ, even though the CBCT positively affected decision-making. No significant increase in knowledge could be confirmed through clinical education. This study highlights the need for students to catch up on MRONJ diagnostics and treatment planning. Further expansion of teaching in this disease’s context and X-ray diagnostics is needed.
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Saatvedt, Ola, Martin Riiser, Frede Frihagen, et al. "Non-operative versus operative treatment of suprasyndesmotic ankle fractures: protocol for a prospective, multicentre, randomised controlled trial." BMJ Open 14, no. 1 (2024): e075122. http://dx.doi.org/10.1136/bmjopen-2023-075122.

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IntroductionSurgery is widely recognised as the treatment of choice for suprasyndesmotic ankle fractures, because of the assumption that these injuries yield instability of the ankle joint. Stability assessment of ankle fractures using weightbearing radiographs is now used regularly to guide the treatment of transsyndesmotic and infrasyndesmotic ankle fractures. Patients with a congruent ankle joint on weightbearing radiographs can be treated non-operatively with excellent results. Weightbearing radiographs are, however, rarely performed on suprasyndesmotic fractures due to the assumed unstable nature of these fractures. If weightbearing radiographs can be used to identify suprasyndesmotic fractures suitable for non-operative treatment, we may save patients from the potential burdens of surgery.Our aim is to compare the efficacy of operative and non-operative treatment of patients with suprasyndesmotic ankle fractures that reduce on weightbearing radiographs.Methods and analysisA non-inferiority randomised controlled trial involving 120 patients will be conducted. A total of 120 patients with suprasyndesmotic ankle fractures with an initial radiographic medial clear space of <7 mm will be subjected to weightbearing radiographs. If the tibio-talar joint is completely reduced, we will randomise in a 1:1 ratio to either operative treatment including reduction and fixation of the syndesmosis or non-operative treatment with an orthosis. The primary study outcome is patient-reported ankle function and symptoms as measured by the Olerud-Molander Ankle Score at 2-year follow-up. Secondary outcomes include the Manchester-Oxford Foot Questionnaire, range of motion, radiographic results and rates of adverse events.Ethics and disseminationThe Regional Committee for Medical and Health Research South East, group A (permission number: 169307), has granted ethics approval. The results of this study will provide valuable insights for developing future diagnostic and treatment strategies for a common fracture type. The findings will be shared through publication in peer-reviewed journals and presentations at conferences.Trial registration numberNCT04615650.
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Huang, Hsiang-Ling, Yun-Han Ma, Che-Chang Tu, and Po-Chun Chang. "Radiographic Evaluation of Regeneration Strategies for the Treatment of Advanced Mandibular Furcation Defects: A Retrospective Study." Membranes 12, no. 2 (2022): 219. http://dx.doi.org/10.3390/membranes12020219.

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Teeth with furcation involvement (FI) present a higher risk of loss and are difficult to maintain. This study evaluated the efficacy of furcation defect regeneration (FDR) as a regeneration strategy. Pre-operative and 6-month postoperative radiographs were collected from patients receiving regeneration therapy for mandibular teeth with degree II and early degree III FI. The linear furcation involvement (LFI), ratio of LFI (RLI), LFI and RLI adjusted bythe alveolar bone crest (ABC), and radiographic intensity were assessed. The effects of demographic characteristics, regeneration treatment strategies, the relationship between furcation and ABC, and adjacent intrabony defect regeneration (AIDR) were evaluated using a generalized linear model and logistic regression. The results demonstrated that 1.5 mm adjusted LFI and 40% adjusted RLI were achieved in both pure furcation defects and combined furcation–angular defects by the combination of bone replacement grafts (BRG) and enamel matrix derivatives (EMD) or collagen membrane (CM); deproteinized bovine bone matrix (DBBM) showed a superior outcome among BRG. In combined furcation–angular defects, EMD appeared more beneficial than CM, and AIDR significantly promoted adjusted LFI and RLI. In conclusion, DBBM with EMD or CM was effective for FDR, and AIDR had a positive effect on FDR in the combined furcation–angular defect.
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Waaler, Dag, Sigrid Hammer, Camilla Langdalen, and Linn Therese Håkonsen Haug. "How radiographers visually perceive X-ray images with the task of accepting or rejecting them – a pilot study." Radiography Open 3, no. 1 (2017): 10. http://dx.doi.org/10.7577/radopen.1997.

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Introduction: Radiographer´s usual role in the medical imaging chain is to acquire relevant and qualitatively good images that help the radiologist or physician to diagnose most accurately. After the image acquisition, the radiographer does a quality evaluation based on established imaging criteria to decide if the image is satisfactory, or otherwise reject it and subsequently take a new one. Contrary to expectations that the number of image rejects should decrease substantially with the introduction of digital imaging, a number of studies have shown that it has not, although the reasons for rejects has changed from exposure errors to positioning and centring errors. Very little research has been on examining how radiographers visually perceive and evaluate the X-ray images in this acceptance/rejection process.Purpose: Investigate how radiographers and radiography students visually perceives X-ray images in the process of accepting or rejecting them on basis of radiographic imaging criteria, and see if there are differences in strategies across experience levels.Materials and methods: Three radiography students and five radiographers with varying years of experience were given the task of accepting or rejecting shoulder and knee projection images based on positioning criteria. Using eye tracking, we measured the participants’ number and duration of gaze fixations within 1) the field of view defined by the monitor display, 2) the part of the monitor displaying the X-ray image only, and 3) the region within the X-ray images considered to be most relevant given the imaging criteria task. The quantitative eye-tracking measurements were followed-up by four qualitative questions.Results: Some differences in fixation patterns between the groups were found; the medium experienced radiographers spent statistically significant lesser number of fixations and lesser average single fixation durations than both the radiography students and the most experienced radiographers did, whereas the two latter groups scored almost equally. Conclusion: The study revealed that work experience might have some influence on how radiographers and radiography students assess X-ray images, but in subtler ways than expected. The study also revealed, however, quite large individual differences across experience.
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Hill, M. P., G. J. Williams, D. H. Kalantar, et al. "Characterization of a 1D-imaging high-energy x-ray backlighter driven by the National Ignition Facility Advanced Radiographic Capability laser." Review of Scientific Instruments 93, no. 10 (2022): 103506. http://dx.doi.org/10.1063/5.0101886.

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Plastic deformation of samples compressed to Mbar pressures at high strain rates at the National Ignition Facility (NIF) forms the basis of ongoing material strength experiments in conditions relevant to meteor impacts, geophysics, armor development, and inertial confinement fusion. Hard x-ray radiography is the primary means of measuring the evolution of these samples, typically employing a slit-collimated high-Z microdot driven by the NIF laser to generate [Formula: see text] keV x rays [E. Gumbrell et al., Rev. Sci. Instrum. 89, 10G118 (2018) and C. M. Huntington et al., Rev. Sci. Instrum. 89, 10G121 (2018)]. Alternatively, a dysprosium “micro-flag” target driven by the Advanced Radiographic Capability laser ([Formula: see text] kJ, 10 ps) can deliver significantly higher spatiotemporal resolution [M. P. Hill et al., Rev. Sci. Instrum. 92, 033535 (2021)], especially in high-opacity samples. Initial experiments revealed problematic brightness and spectral gradients from this source, but by radiographing a set of diamond-turned, 105 µm-thick Pb test objects and supported by simulations using the 3D Monte Carlo code GEANT4, these geometry-dependent gradients across the field of view are quantified and mitigation strategies are assessed. In addition to significantly enhancing the modulation transfer function compared to the existing system, image stacking from multiple layers of image plate is shown to almost double the signal to noise ratio that will reduce uncertainties in future dynamic strength experiments.
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Nair, Sandhya C., Johannes W. J. Bijlsma, Jacobien H. van der Werf, et al. "Do Radiographic Joint Damage and Disease Activity Influence Functional Disability Through Different Mechanisms? Direct and Indirect Effects of Disease Activity in Established Rheumatoid Arthritis." Journal of Rheumatology 40, no. 9 (2013): 1505–12. http://dx.doi.org/10.3899/jrheum.121346.

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Objective.To explore the relationship between rheumatoid arthritis (RA) disease activity and functional disability over time, considering indirect (predictive) and direct (concurrent) associations as well as the influence of radiographic joint damage and treatment strategy.Methods.Functional disability [Health Assessment Questionnaire (HAQ)], disease activity [28-joint Disease Activity Score (DAS28)], and radiographic joint damage [Sharp/van der Heijde score (SHS)] were measured in 4 consecutive randomized controlled trials with increasingly intensive (tight control) treatment strategies. Average followup time for the 3 cohorts was 97, 53, and 50 months, respectively. Next to current DAS28, the previous DAS28 was used to study the predictive effect of a change in DAS28 on progression of functional disability (HAQ). Finally, it was investigated whether SHS mediated the predictive effect of DAS28.Results.In patients treated with intensive treatment strategies, the progression of HAQ over time was statistically significantly less (p < 0.0001). The predictive influence of DAS28 on HAQ progression increased over the duration of the disease. SHS was not found to influence HAQ progression and did not mediate the predictive effect of DAS28. In the less intensively treated patients, the direct effect of disease activity decreased with disease duration, and contrarily, SHS did influence HAQ progression, but was not found to (fully) mediate the predictive effect of DAS28.Conclusion.In patients with RA treated with modern treatment strategies, there is less functional decline over time. Further, disease activity does predict functional decline but joint damage does not. This might indicate that factors associated with cumulative disease activity but not visible on radiographs can influence functional decline in patients with RA. This further underlines the importance of disease activity as a treatment target in early RA and in established RA.
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Chang, Angie, Nabita Singh, Lori Boyd, and Celeste Lawson. "Strategies to Improve Radiographic Practices for Patients With Alzheimer's Disease: A Systematic Review." Journal of Medical Imaging and Radiation Sciences 47, no. 4 (2016): 362–66. http://dx.doi.org/10.1016/j.jmir.2016.09.005.

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Rosenwasser, Katherine A., Hyrum Judd, and Joshua E. Hyman. "Evidence-Based Management Strategies for Pediatric Pes Cavus." Journal of the Pediatric Orthopaedic Society of North America 4, no. 2 (2022): 1–17. http://dx.doi.org/10.55275/jposna-2022-0035.

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Pes cavus is defined as an abnormal elevation of the medial longitudinal arch of the foot. More than two-thirds of patients with pes cavus are found to have an underlying neurologic diagnosis driving a muscle imbalance within the foot. Expedient clinical diagnosis of underlying pathology is paramount to facilitate proper neuraxial imaging studies and a referral to pediatric neurology. Non-operative management is rarely sufficient and is typically indicated only in cases of mild deformity. Surgical management hinges heavily on physical and radiographic examination findings including the Coleman block test, which can help to determine the need for soft tissue or bony reconstruction. The goal of treatment in pes cavus is to obtain a painless, plantigrade, and supple foot.
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Kaku, Shawn, Christopher D. Nguyen, Natalie N. Htet, et al. "Acute Respiratory Distress Syndrome: Etiology, Pathogenesis, and Summary on Management." Journal of Intensive Care Medicine 35, no. 8 (2019): 723–37. http://dx.doi.org/10.1177/0885066619855021.

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The acute respiratory distress syndrome (ARDS) has multiple causes and is characterized by acute lung inflammation and increased pulmonary vascular permeability, leading to hypoxemic respiratory failure and bilateral pulmonary radiographic opacities. The acute respiratory distress syndrome is associated with substantial morbidity and mortality, and effective treatment strategies are limited. This review presents the current state of the literature regarding the etiology, pathogenesis, and management strategies for ARDS.
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Mangus, Courtney W., Bruce L. Klein, Marlene Miller, Dylan Stewart, and Leticia M. Ryan. "Repeat radiographic imaging in patients with long bone fractures transferred to a pediatric trauma center." Journal of Investigative Medicine 67, no. 1 (2018): 59–62. http://dx.doi.org/10.1136/jim-2018-000877.

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This study sought to determine the proportion of children with long bone fractures who undergo duplicate radiographic imaging after transfer to a pediatric trauma center (PTC) for further management. The secondary objective was to explore provider rationale and diagnostic yield of repeat X-rays. This was a single-site, retrospective cohort study conducted at a PTC. All patients, aged 0–21 years, who were transferred to the PTC for management of a long bone fracture were included. Electronic medical records were reviewed to determine the proportion of children who had repeat radiographic imaging and the provider rationale for obtaining this. T-test and Χ2 analyses were used to compare patients who had repeat X-rays with those who did not. During the study period, 309 patients (63% male, mean age 7.2±4.3 years) were transferred from 30 referring hospitals. Of these, 43% (n=133) underwent repeat radiographs. Patient age (p=0.9), gender (p=0.7), fracture location (p=0.19), and type of referring emergency department (pediatric vs general, p=0.3) were not significantly associated with repeat imaging. Rationale for repeat imaging could be ascertained in 31% of cases (n=41); the most common reasons were request by orthopedist (17%, n=23) and suboptimal original imaging (10%, n=13). Repeat imaging at the PTC did not reveal new or additional diagnoses in any case. Nearly half of the children in our study population undergo repeat and likely unnecessary imaging. Strategies to reduce repeat radiographs should be developed, as redundant imaging exposes patients to additional radiation and increases medical expense.
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Brigato, Paolo, Leonardo Oggiano, Sergio De Salvatore, et al. "Final Fusion Strategies in Early-Onset Scoliosis: Does Implant Density Make a Difference After Magnetically Controlled Growing Rod Treatment?" Children 12, no. 6 (2025): 731. https://doi.org/10.3390/children12060731.

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Background/Objectives: Early-onset scoliosis (EOS) frequently requires growth-friendly interventions, such as magnetically controlled growing rods (MCGRs), followed by definitive spinal fusion upon skeletal maturity. The optimal implant density (ID) for final posterior spinal fusion in these patients remains controversial. This study aimed to compare the radiographic, surgical, and economic outcomes associated with high-density (HD) versus low-density (LD) screw constructs in EOS patients previously treated with MCGRs undergoing definitive fusion. Methods: This retrospective study included 27 EOS patients who underwent definitive posterior spinal fusion between January 2017 and September 2022. Participants were categorized into two groups: HD (n = 13) and LD (n = 14). Primary outcomes included coronal and sagittal radiographic parameters assessed at early postoperative and final follow-up visits (minimum of 2 years). The secondary outcomes analyzed were major postoperative complications (grade ≥ IIIB according to Clavien–Dindo–Sink Classification [CDSC]), operative time, blood loss, hospital stay length, and total implant costs. Results: Baseline characteristics between the HD and LD groups were comparable. Early postoperative radiographic assessment demonstrated significantly greater thoracic kyphosis (16.3 ± 7.6° vs. 10.9 ± 14.4°, p = 0.021) and T1-S1 spinal height (43.3 ± 6.7 mm vs. 39.1 ± 4.3 mm, p = 0.039) in the HD group. At final follow-up, only T1-S1 spinal height remained significantly higher in the HD group (45.4 ± 7 mm vs. 39.7 ± 5.1 mm, p = 0.021). Implant costs were significantly higher in the HD group (EUR 6046.5 ± 1146.9 vs. EUR 4376.4 ± 999.4, p < 0.001), while operative time, blood loss, and hospital stay length showed no significant differences. HD constructs had three major complications requiring surgical revision, whereas LD constructs reported no perioperative complications but experienced three late-onset complications also necessitating revision surgery. Conclusions: LD constructs provided comparable long-term radiographic and clinical outcomes to HD constructs, with significantly lower implant-related costs. Despite initial superior kyphosis correction in HD constructs, this benefit diminished by the final follow-up. These findings support a selective, lower-density screw placement strategy to minimize costs and surgical complexity without compromising patient outcomes in EOS undergoing definitive spinal fusion.
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Aebi, Janic, Monika Horisberger, and Arno Frigg. "Radiographic Study of Pes Planovarus." Foot & Ankle International 38, no. 5 (2017): 526–31. http://dx.doi.org/10.1177/1071100717690440.

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Background: Depending on the direction of the subtalar joint, a foot deformity generally tends towards pronation (pes planovalgus) or supination (pes cavovarus). However, the combination of hindfoot varus and flat midfoot/forefoot (pes planovarus) is an exception to this rule. Pes planovarus has so far only been referred to in connection with Müller-Weiss disease and congenital disease. We diagnosed pes planovarus in otherwise healthy patients without these diseases. Methods: Forty patients with 54 symptomatic feet who were treated between August 2012 and July 2016 were included (mean age, 44.1 ± 15.7 years; 15 male/25 female). They were selected from 1064 consecutive cases (3.8%). Inclusion criteria were hindfoot varus and flat midfoot/forefoot. Their symptoms, radiographs, and therapies within the first 3 months were retrospectively analyzed. The position in the hindfoot alignment view (HAV), talometatarsal-1 angle lateral (TMT1lat) and dorsoplantar (TMT1dp), talocalcaneal angle lateral (TCAlat) and dorsoplantar (TCAdp), and calcaneal pitch angle (CPA) were measured on a DICOM/PACS system. Results: The mean radiological results (standard values from the literature in brackets) were as follows: the hindfoot was significantly in varus in the HAV (−6.9 ± 3.6 mm [−1.6 ± 7.2 mm]; P < .001), the TMT1lat was significantly flatter (−6.7 ± 5.8 degrees [8.4 ± 5.9 degrees]; P < .001), the TMT1dp was significantly less in abduction (1.5 ± 7.9 degrees [7.7 ± 8.2 degrees]; P = .005), the TCAdp showed no difference (25.9 ± 7.9 degrees [24.1 ± 5.7 degrees]; P = .118), the TCAlat was significantly larger (47.5 ± 6.1 degrees [43.4 ± 7.1 degrees]; P < .001), and the CPA was significantly flatter (17.6 ± 3.9 degrees [24.5 ± 3.0 degrees]; P < .001). The most frequent symptoms were stress-induced foot pain (n = 33), hallux valgus (n = 20), chronic ankle instability (n = 17), metatarsalgia (n = 15), chronic midfoot pain (n = 13), heel pain (n = 12), and lesser toe deformities (n = 8). Thirty-one feet were treated conservatively and 23 operatively. Conclusion: This study showed the existence of pes planovarus without Müller-Weiss disease or congenital disease. This unusual foot form leads to difficulties if standard treatment strategies are applied, which raises the issue of the correct treatment for such patients. Level of Evidence: Level IV, retrospective case series.
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Rao, Ganesh, Chul S. Ha, Indro Chakrabarti, Iman Feiz-Erfan, Ehud Mendel, and Laurence D. Rhines. "Multiple myeloma of the cervical spine: treatment strategies for pain and spinal instability." Journal of Neurosurgery: Spine 5, no. 2 (2006): 140–45. http://dx.doi.org/10.3171/spi.2006.5.2.140.

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Object Metastases of multiple myeloma often occur in the cervical spine. These metastases may cause pain and associated spinal instability. The authors report the results of radiotherapy and surgical treatment for myeloma involving the cervical spine. The results of radiation therapy for multiple myeloma metastases to the cervical spine that cause clinical or radiographically documented instability have not been reported previously. Methods A retrospective chart review of patients with multiple myeloma metastases to the cervical spine was undertaken. Between 1993 and 2005, 35 patients were treated with external-beam radiation and/or surgical stabilization at the University of Texas M. D. Anderson Cancer Center in Houston, Texas. Nineteen of 20 patients with sufficient follow-up data experienced resolution of their pain when treated with radiation without surgical intervention. Twenty-three patients had evidence of spinal instability on radiographic images; 15 of these were treated with radiation alone. Of these, 10 had sufficient follow-up data, and none showed any clinical progression of instability. Radiographic follow-up images demonstrated an arrest of further progression of instability and, in some cases, healing of pathological fractures by means of radiation alone. Conclusions The results of this series suggest that, in selected cases, external-beam radiation for multiple myeloma metastases to the cervical spine is an effective palliative treatment, even in cases involving clinical or radiographically documented instability.
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Lind, Anna, Ehsan Akbarian, Simon Olsson, et al. "Artificial intelligence for the classification of fractures around the knee in adults according to the 2018 AO/OTA classification system." PLOS ONE 16, no. 4 (2021): e0248809. http://dx.doi.org/10.1371/journal.pone.0248809.

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Background Fractures around the knee joint are inherently complex in terms of treatment; complication rates are high, and they are difficult to diagnose on a plain radiograph. An automated way of classifying radiographic images could improve diagnostic accuracy and would enable production of uniformly classified records of fractures to be used in researching treatment strategies for different fracture types. Recently deep learning, a form of artificial intelligence (AI), has shown promising results for interpreting radiographs. In this study, we aim to evaluate how well an AI can classify knee fractures according to the detailed 2018 AO-OTA fracture classification system. Methods We selected 6003 radiograph exams taken at Danderyd University Hospital between the years 2002–2016, and manually categorized them according to the AO/OTA classification system and by custom classifiers. We then trained a ResNet-based neural network on this data. We evaluated the performance against a test set of 600 exams. Two senior orthopedic surgeons had reviewed these exams independently where we settled exams with disagreement through a consensus session. Results We captured a total of 49 nested fracture classes. Weighted mean AUC was 0.87 for proximal tibia fractures, 0.89 for patella fractures and 0.89 for distal femur fractures. Almost ¾ of AUC estimates were above 0.8, out of which more than half reached an AUC of 0.9 or above indicating excellent performance. Conclusion Our study shows that neural networks can be used not only for fracture identification but also for more detailed classification of fractures around the knee joint.
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Giai Via, Riccardo, Francesco Onorato, Michele Reboli, et al. "Challenges in Total Hip Arthroplasty with Prior Spinal Arthrodesis: A Comprehensive Review of Biomechanics, Complications, and Surgical Strategies." Journal of Clinical Medicine 13, no. 11 (2024): 3156. http://dx.doi.org/10.3390/jcm13113156.

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Total hip arthroplasty (THA) has revolutionized patients’ lives with hip osteoarthritis. However, the increasing prevalence of THA in individuals with prior lumbar arthrodesis (LA) poses unique challenges. This review delves into the biomechanical alterations, complications, and surgical strategies specific to this patient subset, highlighting the need for tailored preoperative assessments and planning. Due to altered pelvic and spinal biomechanics, patients with LA undergoing THA face a higher risk of dislocation and revision. The complex interplay between spinal and hip biomechanics underscores the need for meticulous preoperative planning. Comprehensive clinical examination and radiographic evaluation are vital for understanding patient-specific challenges. Various radiographic techniques, including computed tomography (CT)/X-ray matching and standing/seated studies, provide insights into postural changes affecting pelvic and spinal alignment. Complications following THA in patients with LA highlight the necessity for personalized surgical strategies. Careful consideration of implant selection, the surgical approach, and component positioning are essential to prevent complications. In summary, THA in patients with prior LA demands individualized preoperative assessments and planning. This approach is crucial to optimize outcomes and mitigate the heightened risks of complications, underlining the importance of tailored surgical strategies.
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Srinivasan, C. P., and P. Durgesh. "Peripheral Ossifying Fibroma: A Case Report and Review of Literature." Nigerian Dental Journal 27, no. 1 (2019): 23–28. http://dx.doi.org/10.61172/ndj.v27i1.95.

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Peripheral ossifying fibroma (POF) is an infrequently occurring, slowly progressing, innocuous, nodular overgrowth of the gingiva, which belongs to the category of the “reactive lesions of the gingiva.” There are several such overgrowths with similar clinical manifestations, but diverse etiology and histopathological features, thus presenting a challenge for the clinician. Thorough clinical examination, radiographic and histopathological features help to establish the diagnosis which is key to the successful management of such lesions. This article describes a case of POF in a 43-year-old male patient. The clinical, radiographic, histologic features, aggressive treatment strategies, relapse and close follow-up of POF are discussed in detail.
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Dhall, Sanjay S., Tanvir F. Choudhri, Jason C. Eck, et al. "Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 5: Correlation between radiographic outcome and function." Journal of Neurosurgery: Spine 21, no. 1 (2014): 31–36. http://dx.doi.org/10.3171/2014.4.spine14268.

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In an effort to diminish pain or progressive instability, due to either the pathological process or as a result of surgical decompression, one of the primary goals of a fusion procedure is to achieve a solid arthrodesis. Assuming that pain and disability result from lost mechanical integrity of the spine, the objective of a fusion across an unstable segment is to eliminate pathological motion and improve clinical outcome. However, conclusive evidence of this correlation, between successful fusion and clinical outcome, remains elusive, and thus the necessity of documenting successful arthrodesis through radiographic analysis remains debatable. Although a definitive cause and effect relationship has not been demonstrated, there is moderate evidence that demonstrates a positive association between radiographic presence of fusion and improved clinical outcome. Due to this growing body of literature, it is recommended that strategies intended to enhance the potential for radiographic fusion are considered when performing a lumbar arthrodesis for degenerative spine disease.
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Taşkın, Recep, and Mehmet Köse. "Evaluation of long-term clinical and radiographic outcomes of arthroscopic bankart repair: a five-year retrospective study." Kastamonu Medical Journal 5, no. 1 (2025): 60–65. https://doi.org/10.51271/kmj-0185.

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Aims: This study examined the clinical and radiographic results of individuals following arthroscopic Bankart shoulder stabilization over a minimum of five years. Additionally, methodological quality and bias evaluations were conducted to enhance the study's scientific legitimacy. Methods: A retrospective analysis was conducted on 103 individuals who had arthroscopic Bankart repair between 2010 and 2015. A history of anterior shoulder dislocation and a minimum 5-year follow-up time were prerequisites for inclusion. The Chi-square test was used to examine the clinical and radiographic data, and a significance level of p<0.05 was approved. Results: Radiographic assessments revealed normal results, and 80.58% of individuals had excellent clinical outcomes. The rates of subluxation and recurrent dislocation were 7.77% and 11.65%, respectively. The results showed that the right side performed better than the left. Conclusion: Following arthroscopic Bankart surgery, low recurrence rates and good patient satisfaction were noted. Gender and side differences, however, highlight the significance of tailored treatment strategies.
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Kishimoto, Mitsumasa, Keisuke Ono, Sho Fukui, et al. "Clinical characteristics of non-radiographic versus radiographic axial spondyloarthritis in Asia and non-radiographic axial spondyloarthritis in other regions: results of the cross-sectional ASAS-COMOSPA study." RMD Open 7, no. 3 (2021): e001752. http://dx.doi.org/10.1136/rmdopen-2021-001752.

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ObjectivesTo delineate characteristics of non-radiographic axial spondyloarthritis (nr-axSpA) in Asia versus non-Asian regions, and compare radiographic axSpA (r-axSpA) with nr-axSpA within Asia.MethodsData were collected from the Assessment of SpondyloArthritis international Society-COMOrbidities in SPondyloArthritis database. Categorising patients by region, we compared clinical characteristics between nr-axSpA from Asia vs elsewhere (Europe, the Americas and Africa). Within Asians, we additionally compared patient characteristics of those with nr-axSpA versus r-axSpA.ResultsAmong 3984 SpA cases, 1094 were from Asian countries. Of 780 axSpA patients in Asia, 112 (14.4%) had nr-axSpA, less than in non-Asian countries (486/1997, 24.3%). Nr-axSpA patients in Asia were predominantly male (75.9% vs 47.1%), younger at onset (22.8 vs 27.8 years) and diagnosis (27.2 vs 34.5 years), and experienced less diagnostic delay (1.9 vs 2.9 years) compared with nr-axSpA in non-Asian countries. Nr-axSpA in Asia exhibited higher human leucocyte antigens-B27 prevalence (90.6% vs 61.9%), fewer peripheral SpA features (53.6% vs 66.3%) and similar extra-articular and comorbid disease rates compared with those with nr-axSpA in non-Asian countries. Disease activity, functional impairment and MRI sacroiliitis were less in nr-axSpA in Asia, with higher rates of non-steroidal anti-inflammatory drug response and less methotrexate and biological disease-modifying antirheumatic drugs use. Within Asia, r-axSpA showed higher disease activity and structural damage compared with nr-axSpA, with no differences in other features.ConclusionAmong axSpA, lower frequency of nr-axSpA was observed in Asia. Our results offer an opportunity to better understand clinical characteristics and optimise diagnostic strategies, such as ensuring access and availability of MRI resources for accurate diagnosis of nr-axSpA in Asia.
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Beck, Randy W., Kelly R. Holt, Marina A. Fox, and Kristin L. Hurtgen-Grace. "Radiographic Anomalies That May Alter Chiropractic Intervention Strategies Found in a New Zealand Population." Journal of Manipulative and Physiological Therapeutics 27, no. 9 (2004): 554–59. http://dx.doi.org/10.1016/j.jmpt.2004.10.008.

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Ammendolia, Carlo. "Radiographic Anomalies That May Alter Chiropractic Intervention Strategies Found in a New Zealand Population." Journal of Manipulative and Physiological Therapeutics 28, no. 5 (2005): 375. http://dx.doi.org/10.1016/j.jmpt.2005.04.013.

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Budaychiev, G. M. A., T. A. Abakarov, K. M. Alieva-Kharkharova, and S. M. Makkaeva. "Personalized treatment strategies for peri-implantitis in elderly patients with impaired osteogenesis." Russian Journal of Geriatric Medicine, no. 2 (May 5, 2025): 196–98. https://doi.org/10.37586/2686-8636-2-2025-196-198.

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RELEVANCE. Peri-implantitis is one of the leading causes of dental implant failure, particularly in elderly patients with impaired osteogenesis. Age-related changes, osteoporosis, osteopenia, and comorbid conditions such as diabetes mellitus and cardiovascular diseases reduce the regenerative potential of bone tissue, complicating the treatment of peri-implantitis. Standard treatment methods for peri-implantitis often prove insufficiently effective, as they do not account for individual variations in bone metabolism. Therefore, the development of personalized approaches based on the assessment of biochemical markers of osteogenesis, radiographic bone density, and systemic risk factors is a crucial objective in modern dentistry.
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Kosciuk, Patrick, Cristopher Meyer, Kathryn A. Wikenheiser-Brokamp, and Francis X. McCormack. "Pulmonary alveolar microlithiasis." European Respiratory Review 29, no. 158 (2020): 200024. http://dx.doi.org/10.1183/16000617.0024-2020.

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Pulmonary alveolar microlithiasis (PAM) is a fascinating rare lung disease that is associated with the accumulation of hydroxyapatite microliths within the lumen of the alveolar spaces. In most patients, PAM is discovered incidentally on radiographs performed for other purposes, and the typical disease course is characterised by slowly progressive respiratory insufficiency over decades. Recent genetic analyses that have revealed that the deficiency of the sodium-phosphate cotransporter NPT2B is the cause of PAM have enabled the development of powerful animal models that inform our approach to disease management and treatment. Here we review the epidemiology and molecular pathophysiology of PAM, as well as the diagnostic approach, clinical manifestations, radiographic and pathologic features, and clinical management of the disease. Although there are no proven treatments for PAM, progress in our understanding of disease pathogenesis is providing insights that suggest strategies for trials.
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43

Altamirano, Sara, Mylène P. Jansen, Daniel L. Oberski, et al. "Identifying multivariate disease trajectories and potential phenotypes of early knee osteoarthritis in the CHECK cohort." PLOS ONE 18, no. 7 (2023): e0283717. http://dx.doi.org/10.1371/journal.pone.0283717.

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Objective To gain better understanding of osteoarthritis (OA) heterogeneity and its predictors for distinguishing OA phenotypes. This could provide the opportunity to tailor prevention and treatment strategies and thus improve care. Design Ten year follow-up data from CHECK (1002 early-OA subjects with first general practitioner visit for complaints ≤6 months before inclusion) was used. Data were collected on WOMAC (pain, function, stiffness), quantitative radiographic tibiofemoral (TF) OA characteristics, and semi-quantitative radiographic patellofemoral (PF) OA characteristics. Using functional data analysis, distinctive sets of trajectories were identified for WOMAC, TF and PF characteristics, based on model fit and clinical interpretation. The probabilities of knee membership to each trajectory were used in hierarchical cluster analyses to derive knee OA phenotypes. The number and composition of potential phenotypes was selected again based on model fit (silhouette score) and clinical interpretation. Results Five trajectories representing different constant levels or changing WOMAC scores were identified. For TF and PF OA, eight and six trajectories respectively were identified based on (changes in) joint space narrowing, osteophytes and sclerosis. Combining the probabilities of knees belonging to these different trajectories resulted in six clusters (‘phenotypes’) of knees with different degrees of functional (WOMAC) and radiographic (PF) parameters; TF parameters were found not to significantly contribute to clustering. Including baseline characteristics as well resulted in eight clusters of knees, dominated by sex, menopausal status and WOMAC scores, with only limited contribution of PF features. Conclusions Several stable and progressive trajectories of OA symptoms and radiographic features were identified, resulting in phenotypes with relatively independent symptomatic and radiographic features. Sex and menopausal status may be especially important when phenotyping knee OA patients, while radiographic features contributed less. Possible phenotypes were identified that, after validation, could aid personalized treatments and patients selection.
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Eyssartier, Camille, Pierre Billard, Patricia Thoreux, and Christophe Sauret. "Spine Kinematics Behavior During the Handstand Posture: A Biplanar Radiographic Analysis." Journal of Functional Morphology and Kinesiology 9, no. 4 (2024): 252. https://doi.org/10.3390/jfmk9040252.

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Background/Objectives: The handstand is an exercise performed in many sports, either for its own sake or as part of physical training. Unlike the upright bipedal standing posture, little is known about the sagittal alignment and balance of the spine during a handstand, which may hinder coaching and reduce the benefits of this exercise if not performed correctly. The purpose of this study was to quantify the sagittal alignment and balance of the spine during a handstand using radiographic images to characterize the strategies employed by the spino-pelvic complex during this posture. Methods: Nineteen national-level artistic gymnasts participated in this study and underwent a low-dose biplanar (frontal and lateral) radiograph in both upright bipedal standing posture and during a handstand. Then, 3D reconstruction of the spine, based on biplanar radiographic images, enabled the determination of key pelvic (pelvic incidence, sacral slope, pelvic tilt) and spinal (lumbar lordosis, thoracic kyphosis, T9 sagittal offset) parameters in both postures. Results: The results showed that most gymnasts performed pelvic retroversion during the handstand, which was accompanied by an average decrease in lumbar lordosis, thoracic kyphosis, and T9 sagittal offset. Additionally, lumbar curvature was found to depend on pelvic orientation in upright bipedal standing posture, whereas it was associated with the thoracic spine during the handstand. Conclusions: This study provides new insights into how the spine kinematically adapts to an inverted body load. The results may help coaches and physiotherapists in teaching the handstand or using it to rehabilitate and strengthen the spine through the handstand posture.
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SURESHKUMAR, R., Akhter RASOOL, T. SARATH, C. PUGAZHARASI, and K. KRISHNAKUMAR. "Unveiling a rare case: cyclopia and its radiographic features in a non-descript primiparous heifer." Notulae Scientia Biologicae 16, no. 1 (2024): 11648. http://dx.doi.org/10.55779/nsb16111648.

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Cyclopia, an exceedingly rare congenital anomaly, presents intricate deformities affecting the skull, orbits, brain, and nasal cavity, often featuring a singular or partially divided eye within a solitary orbit. Despite medical advancements, the precise etiology of cyclopia remains elusive, with emerging evidence suggesting a potential association with chromosomal aberrations. Timely detection of cyclopia is crucial for effective management and can be facilitated through ultrasonographic techniques. This case report provides a comprehensive exploration of cyclopia, elucidating both gross and radiographic features. Gross examination of the affected fetus unveiled a dysmorphic face characterized by a centrally located single eye, atresia of the nasal conchae, and micrognathia, collectively indicative of cyclopia. Radiographic analysis further revealed a small, severely deformed head, emphasizing malformations in the maxilla and the notable absence of frontal, nasal, and incisive bones. Synthesizing gross and radiographic observations, this report enhances the existing knowledge on this rare congenital anomaly, contributing to a deeper understanding of its complexities for veterinary healthcare professionals and researchers. Such insights are essential for advancing effective management strategies and fostering ongoing research in the realm of veterinary medicine.
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Suwatanapongched, Thitiporn, Chayanin Nitiwarangkul, Warawut Sukkasem, and Sith Phongkitkarun. "Rama Co-RADS: Categorical Assessment Scheme of Chest Radiographic Findings for Diagnosing Pneumonia in Patients With Confirmed COVID-19." Ramathibodi Medical Journal 44, no. 2 (2021): 50–62. http://dx.doi.org/10.33165/rmj.2021.44.2.251259.

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Due to the rapid spread of COVID-19 during the third wave of infection in Thailand, the number of confirmed COVID-19 cases has increased exponentially since April 2021. As a result, the country’s healthcare facilities and personnel are overwhelmed. Hence, many new intervention strategies have been designed and implemented. In such a resource-constrained condition, multiple alternate care sites, such as converted hotels (the so-called hospitels) and mobile field medical units, have been established for quarantine and taking care of confirmed COVID-19 cases having no or mild symptoms. In this context, it is essential to have clinical and chest radiographic assessment as a baseline screening for an accurate and rapid triage of patients and early detection of COVID-19 pneumonia, which significantly impacts patient outcomes. Therefore, a clear, concise and standardized chest radiographic report is mandatory. To facilitate this process, the authors have introduced Rama Co-RADS for the categorical assessment scheme of pulmonary involvement in COVID-19. After the pilot implementation of Rama Co-RADS in the routine radiology workflow for chest radiography screening in patients with confirmed COVID-19 at the Ramathibodi Hospitels, there is a 24% reduction in the median turnaround radiology reporting time. It also enhances the radiologist’s performance in establishing the diagnosis of COVID-19 pneumonia (especially in the early phase). Furthermore, the categorical assessment scheme in Rama Co-RADS facilitates communication among healthcare personnel, guiding effective management, triage, consultation and treatment of patients with confirmed COVID-19.
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Pelsma, Iris C. M., Nienke R. Biermasz, Wouter R. van Furth, et al. "Progression of acromegalic arthropathy in long-term controlled acromegaly patients: 9 years of longitudinal follow-up." Journal of Clinical Endocrinology & Metabolism 106, no. 1 (2020): 188–200. http://dx.doi.org/10.1210/clinem/dgaa747.

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Abstract Context Joint complaints in patients with acromegaly are common, although the long-term disease course is largely unknown. Objective This study aims to evaluate the long-term course of acromegalic arthropathy. Design and Setting A prospective longitudinal cohort study was conducted in controlled acromegaly patients followed at a tertial referral center, with 3 study visits: at baseline and after a median of 2.6 and 9.1 years. Patients We included 31 patients with biochemically controlled acromegaly for 2 or more years (49% female; median age, 60 years) at baseline. Main Outcome Measures Radiographic arthropathy of the knee, hip, hand, and cervical and lumbar spine were evaluated using Kellgren and Lawrence (KL) scores, developed for assessment of primary osteoarthritis (OA). Radiographic progression was defined as a KL increase above the smallest detectable change. Joint symptoms were assessed using self-reported questionnaires. Progression was defined using existing clinically important cutoff values. Risk factors for progression were investigated using a multivariable model. Results All patients had definite radiographic OA at 1 or more joints at baseline. Radiographic progression was observed in 29%, 48%, 84%, and 94% of patients in the knees, hips, hands, and axial joints, respectively. Deterioration in hand-related pain and function was observed in 10 (32.3%) and 11 patients (35.5%), respectively. Solely baseline KL scores of the hip were associated with hip OA progression (OR 1.88; 95% CI, 1.09-3.16). Conclusions Acromegalic arthropathy showed significant radiographic progression over 9.1 years of follow-up in patients in remission, whereas clinical progression was observed less frequently. Future studies should focus on adequate prevention and treatment strategies of acromegalic arthropathy.
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Chaudhary, Puneet, Swati Saxena, Rajesh Kumar Maurya, and Mahendra Kumar Pant. "Pedographic and radiographic analysis of foot and its clinical implication." Journal of Anatomical Sciences 32, no. 2 (2024): 53–65. https://doi.org/10.46351/jas.v32i2pp53-65.

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Introduction: Foot posture plays a crucial role in musculoskeletal health by influencing the dynamic function and alignment of the lower limbs. Alterations in foot biomechanics, such as flatfoot, have been linked to the development and progression of medial compartment knee osteoarthritis (OA). Pedography, a non-invasive technique to assess foot posture, provides detailed visualization of footprints and may serve as an effective screening tool for early identification and management of foot malalignment using orthotics. Materials and Methods: This case-control study assessed pedographic parameters (Arch index and Arch angle) and radiographic parameters (calcaneal pitch angle and cuboid abduction angle) in 45 patients with clinically and radiologically confirmed medial knee OA and 33 age-matched healthy controls from the Dehradun district. Additional radiographic angles measured included Meary’s angle, talo-calcaneal angle, and talo-navicular coverage angle. The correlation between pedographic and radiographic parameters was analyzed, along with demographic factors such as BMI, age, and gender. Results: Significant differences were found in both pedographic and radiographic measurements between individuals with and without knee OA. Pronated foot posture (elevated Arch index and reduced Arch angle) was more prevalent in the OA group. The cuboid abduction angle (CAA) and calcaneal pitch angle (CPA) also showed significant associations with OA status (p = 0.000 and 0.035, respectively). BMI was significantly associated with OA presence. Conclusions: Pronated flatfoot was more common in individuals with medial knee OA, suggesting a biomechanical link. Pedographic assessment offers a useful, radiation-free alternative for early screening and prevention strategies, especially in rural settings where radiographic resources are limited. Keywords: Arch index, Calcaneal pitch, Foot health, BMI, Foot alignment
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S Gupta, Himani, Manan M Doshi, Vanashree P Saple, and Sneha Rajguru. "Myriad Treatment Strategies for Mitigating Apicomarginal Defects - A Case Series." International Journal of Health Sciences and Research 15, no. 3 (2025): 110–17. https://doi.org/10.52403/ijhsr.20250318.

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Background: The endodontic periodontic continuum harbours dysbiotic microorganisms, leading to apicomarginal defects with inevitable breakdown of cortical bone. Guided tissue regeneration, using autograft, allograft, xenograft or alloplast coupled with resorbable membranes is a holistic way of achieving predictable regeneration. Methods and Material: Two varied cases of apicomarginal defects were treated surgically. The first case had an endodontic treatment followed by regenerative surgery using autologous platelet rich fibrin and xenograft. The second case was of surgical intervention with an alloplast and bioresorbable membrane for defect elimination. Results: Follow-up clinical and radiographic documentation of both cases shows how correct diagnosis and surgical treatment protocol can increase the longevity of compromised teeth. Conclusions: Guided tissue regeneration with barrier membrane has demonstrated to provide favourable results and has gained wide acceptance in treating unpredictable apicomarginal defects. Key words: Endo Perio lesion, Guided Tissue Regeneration, Apicomarginal defect
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Rebouças, Pedro Diniz, Lorena Walesca Macedo Rodrigues, Adriana Kelly de Sousa Santiago, Clarice Santana Milagres, Juliana Oliveira Gondim, and José Jeová Siebra Moreira-Neto. "COMPARISON BETWEEN THE USE OF PANORAMIC RADIOGRAPHY AND CONE BEAM COMPUTED TOMOGRAPHY TO LOCATE DENTAL ELEMENTS SEVERE INTRUDED DUE TO TRAUMA: CASE REPORT." Pensar Acadêmico 11, no. 2 (2019): 39–45. http://dx.doi.org/10.21576/rpa.2014v11i2.1016.

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Intrusive luxation is a kind of traumatic injury characterized by an axial displacement of the tooth toward the alveolar bone. Its main causes are bicycle accidents, sports/recreational activities, and falls or collisions. Treatment strategies include waiting for the tooth to return to its position, immediate surgical repositioning and repositioning through dental traction by orthodontic devices. The correct diagnosis must be based on clinical and radiographic exams and it is crucial for decision-making in the treatment of injured patients. Currently, the cone beam computed tomography (CBCT) has been widely used in orthodontics, restorative dentistry and implantology as well as in the diagnosis of complex dental trauma. This article reports a case of severe dental intrusion, in which the cone beam computed tomography (CBCT) was performed because of doubts generated after clinical examination and panoramic radiograph analyze. This case report confirmed that the CBCT is an important exam to correct diagnostic.
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