Academic literature on the topic 'Radiopharmaceutical'

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Journal articles on the topic "Radiopharmaceutical"

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Budinský, Michal, Petr Vyšinský, Zdeněk Řehák, and Jan Adam. "Experience with the Preparation of ⁶⁸Ga-PSMA-11." Chemické listy 116, no. 12 (2022): 746–50. http://dx.doi.org/10.54779/chl20220746.

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The radiopharmaceutical 68Ga-PSMA-11 represents a radiopharmaceutical drug without marketing authorization for the prostate cancer diagnosis in a specific treatment program. In respect of the radiopharmaceutical technology, the difficultness of the preparation of 68Ga-PSMA-11 is comparable to that of conventional radiopharmaceuticals.
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Budinský, Michal, and Vendula Janků. "Porovnání přípravy radiofarmaka 68Ga-PSMA-11 na dvou českých pracovištích." Česká a slovenská farmacie 72, no. 3 (2023): 125–31. http://dx.doi.org/10.5817/csf2023-3-125.

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Radiopharmaceutical 68Ga-PSMA-11 is one of the newest positron radiopharmaceuticals available for nuclear medicine departments in the Czech Republic. The radiopharmaceutical preparation can be carried out manually or instrumentally using modules for synth
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Budinský, Michal, Petr Vyšinský, Stanislav Synek, Beatrix Bencsiková, Iveta Selingerová, and Zdeněk Řehák. "68Ga-DOTATOC." Česká a slovenská farmacie 70, no. 4 (2021): 136–41. http://dx.doi.org/10.5817/csf2021-4-136.

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The radiopharmaceutical 68Ga-DOTATOC represents the latest radiopharmaceutical in the diagnosis of a neuroendocrine tumor with somatostatin receptor overexpression. Technological and economic difficulties of preparing and quality control of the radiopharmaceutical limit its use to specialised departments. Background of the department with rich experience with radiopharmaceuticals for positron emission tomography allows handling more difficult 68Ga-radiopharmacy and may increase and improve the care of oncology patients.
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Kunos, Charles A., and Jacek Capala. "National Cancer Institute Programmatic Collaboration for Investigational Radiopharmaceuticals." American Society of Clinical Oncology Educational Book, no. 38 (May 2018): 488–94. http://dx.doi.org/10.1200/edbk_200199.

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Radiopharmaceutical therapies have provided an attractive therapeutic approach since the introduction of 131I to treat thyroid cancer. New insights in cancer biology and radiochemistry have brought radiopharmaceuticals to the leading edge of oncology clinical research. National Cancer Institute (NCI) programs watch for new radiopharmaceutical breakthroughs that should be used to treat patients with unmet therapeutic needs. Such efforts occur through leveraged partnerships between NCI’s Cancer Therapy Evaluation Program and its Radiation Research Program. If groundbreaking discoveries are made,
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SAW, MAUNG MAUNG. "MEDICINAL RADIOPHARMACEUTICAL CHEMISTRY OF METAL RADIOPHARMACEUTICALS." COSMOS 08, no. 01 (2012): 11–81. http://dx.doi.org/10.1142/s0219607712300044.

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Metal complexes have been used as medicinal compounds. Metals have advantageous features over organic compounds. Significant applications of metal complexes are in the field of nuclear medicine. Radiopharmaceuticals are drugs containing radioisotopes used for diagnostic and therapeutic purposes. The generalized targeting strategy for molecular imaging probe consists of three essential parts: (i) reporter unit or payload, (ii) carrier, and (iii) targeting system. Medicinal radiopharmaceutical chemistry pays special consideration to radioisotopes, as a reporter unit for diagnostic application or
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Kunos, Charles A., and Rita Abdallah. "Financial Toxicity Encountered in Therapeutic Radiopharmaceutical Clinical Development for Ovarian Cancer." Pharmaceuticals 13, no. 8 (2020): 181. http://dx.doi.org/10.3390/ph13080181.

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Financial toxicity or the debt a cancer survivor incurs from the costs of their medical cancer care is an understudied aspect in the clinical development of experimental therapeutic agents. The United States National Cancer Institute (NCI) Cancer Therapy Evaluation Program studies experimental therapeutic agents like radiopharmaceuticals in both early and late phase trials, which provide opportunities to comprehend more clearly the possible sources of financial toxicity incurred by cancer survivors. We reviewed the academic scholarship describing fiscal and social costs involved in the develop
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Ganaie, Sameer Ahmad, Ruqiya Ramzan, and Mubashir Habib. "Radiopharmaceuticals-Emerging Trends and Applications in diagnostic Imaging and Therapy." International Journal of Health Sciences and Research 15, no. 2 (2025): 85–99. https://doi.org/10.52403//ijhsr.20250211.

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The landscape of nuclear medicine is undergoing a profound transformation, driven by the rapid evolution of radiopharmaceuticals. These innovative agents are redefining the boundaries of diagnostic imaging and targeted therapy, offering unprecedented opportunities for precision medicine. This comprehensive review article provides a cutting-edge overview of the emerging trends and applications of radiopharmaceuticals in diagnostic imaging and therapy. We delve into the latest advancements in radiopharmaceutical design, synthesis, and application, including the development of novel isotopes, pep
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Koźmiński, Przemysław, Paweł Krzysztof Halik, Raphael Chesori, and Ewa Gniazdowska. "Common Shortcomings in Study on Radiopharmaceutical Design Research: A Case Study of 99mTc-Labelled Methotrexate." Molecules 26, no. 19 (2021): 5862. http://dx.doi.org/10.3390/molecules26195862.

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The aim of the work carried out was to draw attention to shortcomings that often appear at the stage of designing new radiopharmaceuticals. Based on a case study of 99mTc-labelled methotrexate, this article describes frequent mistakes or misconceptions present not only in the referenced studies, but also in numerous radiopharmaceutical studies. The recommendations provided in this article highlight fundamental aspects of the credibility of radiopharmaceutical scientific research leading to the reliable results.
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Chiang, Ping Fang. "Development of INER-PP-F11N as the radionuclide theragnostics agent against cholecystokinin B receptor-overexpressed tumors." JCO Global Oncology 9, Supplement_1 (2023): 164. http://dx.doi.org/10.1200/go.2023.9.supplement_1.164.

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164 Background: We aimed to evaluate an albumin affinity structure-containing radiopharmaceutical agents INER-PP-F11N-1 and INER-PP-F11N-2 for diagnostic/therapeutic the CCK2R-overexpressed cancers. Methods: We developed the radionuclide labeled In-111/Lu-177-INER-PP-F11N radiopharmaceuticals in comparison with the current PP-F11N to investigate the radiochemical purity, SPECT/CT imaging, bio-distribution, and therapeutic responses in CCK2R-expressing tumor xenograft mice. Results: The radiochemical purity of In-111/Lu-177-INER-PP-F11N radiopharmaceuticals reached more than 90% after 144 hours
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Kleynhans, Janke, Hendrik Gerhardus Kruger, Theunis Cloete, Jan Rijn Zeevaart, and Thomas Ebenhan. "In Silico Modelling in the Development of Novel Radiolabelled Peptide Probes." Current Medicinal Chemistry 27, no. 41 (2020): 7048–63. http://dx.doi.org/10.2174/0929867327666200504082256.

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This review describes the usefulness of in silico design approaches in the design of new radiopharmaceuticals, especially peptide-based radiotracers (including peptidomimetics). Although not part of the standard arsenal utilized during radiopharmaceutical design, the use of in silico strategies is steadily increasing in the field of radiochemistry as it contributes to a more rational and scientific approach. The development of new peptide-based radiopharmaceuticals as well as a short introduction to suitable computational approaches are provided in this review. The first section comprises a co
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Dissertations / Theses on the topic "Radiopharmaceutical"

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Suliman, Zaahirah. "A qualitative evaluation on the appropriateness of the current regulatory guidelines, on the manufacture of medicines within the radiopharmaceutical industry." University of the Western cape, 2016. http://hdl.handle.net/11394/5658.

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Magister Pharmaceuticae - MPharm<br>The purpose of this research thesis, is to evaluate the appropriateness of the current regulatory guidelines on the manufacture of medicinal products within the radiopharmaceutical industry. The manufacture of radiopharmaceuticals is governed by two main regulatory bodies. The regulatory authority responsible for the governance of the pharmaceutical product has the primary objective of ensuring the safety, efficacy and purity of the products manufactured, while the nuclear regulator has the responsibility of ensuring that the products used and manufactured a
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Puncher, M. "Microautoradiography in radiopharmaceutical research." Thesis, University of Kent, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281658.

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Heslop, Julia M. "Copper complexes with potential radiopharmaceutical applications." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418800.

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Allan, Cheryll Clare. "Synthesis of rigid tetraazamacrocycles : radiopharmaceutical applications." Thesis, University of Hull, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417150.

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Walker, Paul Saunders. "New chelating systems for radiopharmaceutical diagnosis." Thesis, University of Southampton, 1997. https://eprints.soton.ac.uk/361137/.

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This thesis concerns the design of novel binding agents for radioisotopes having potential application in radiopharmaceutical imaging systems. The first section reviews the currently available methods of radioimaging with particular emphasis on the limitations of the pharmaceutical reagents currently used for this important medical diagnostic tool. The main focus of the work concerns: (i) the design and study of a particular class of novel radiopharmaceutical hosts based on a well-established group of polydentate ligands, the propylene amine oximes (PnAOs); and (ii) the evaluation of various t
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Mora, Ramirez Erick. "Radiopharmaceutical dosimetry in targeted radionuclide therapy." Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30012.

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La médecine nucléaire est une spécialité médicale dont l'une des applications est l'étude de la physiologie des organes et du métabolisme de divers types de tumeurs. Les produits pharmaceutiques liés à un isotope radioactif (médicament radio-pharmaceutique, MRP) sont étudiés en préclinique avant d'être utilisés chez l'homme. Les rongeurs sont généralement utilisés pour étudier la bio-cinétique du traceur dans un groupe d'organes prédéfinis. L'extrapolation des résultats de ces études de l'animal à l'homme permet d'avoir une estimation du comportement des MRP et de l'irradiation délivrée en cli
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Easson, Morag Ann Maccall. "Synthesis of tailored ligands for radiopharmaceutical applications." Thesis, Durham University, 1997. http://etheses.dur.ac.uk/4916/.

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An important aspect of clinical imaging techniques involves the use of complexed gamma or positron-emitting radionuclides, e.g. (^99m)Tc(γ, t1/2 = 6.02 h, 141 keV) for Single Photon Emission Tomography (SPET), (^62)Cu (β(^+),t1/2 = 9.74 min, 1.315 MeV) for Positron Emission Tomography (PET). With such radiopharmaceuticals in mind, two new classes of acyclic tetradentate ligands have been synthesised, featuring an N(_2)S(_2) donor system. This array of donor atoms is particularly attractive for its 'soft’ metal preference, favouring the complexation of radionuclides such as (^64)Cu and (^99m)Tc
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Tran, Anh My. "Synthesis of bifunctional chelates for potential radiopharmaceutical applications." Thesis, University of Essex, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247010.

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Morgan, G. F. E. "Chemical and radiopharmaceutical studies of technetium containing complexes." Thesis, Loughborough University, 1987. https://dspace.lboro.ac.uk/2134/13763.

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The work described within this thesis takes the form of several different but related projects. The radionuclide, 99mTc, is widely used in nuclear medicine departments and researched in many laboratories throughout the world today and it is the intention of this thesis to contribute to the growing library of knowledge in this field. In chapter three, the technetium complex of tiron, a disulphonato derivative of catechol, is assessed for its radiopharmaceutical efficacy using both animal and human models. The no carrier added [ 99mTc] Tctiron preparation appears to form a single radiochemical s
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Seifert, S., and J. Van Den Hoff. "Annual Report 2004 - Institute of Bioinorganic and Radiopharmaceutical Chemistry." Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-28695.

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Books on the topic "Radiopharmaceutical"

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Lewis, Jason S., Albert D. Windhorst, and Brian M. Zeglis, eds. Radiopharmaceutical Chemistry. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-98947-1.

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Bodei, Lisa, Jason S. Lewis, and Brian M. Zeglis, eds. Radiopharmaceutical Therapy. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-39005-0.

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Pecorale, Andrea, Maria Carmela Inzerillo, and Piero A. Salvadori. PET Radiopharmaceutical Business. Springer Nature Switzerland, 2023. http://dx.doi.org/10.1007/978-3-031-51908-6.

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1948-, Nunn Adrian D., ed. Radiopharmaceutical: Chemistry and pharmacology. M. Dekker, 1992.

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Lambrecht, Richard M. Biological Models in Radiopharmaceutical Development. Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-009-0159-9.

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Schwochau, Klaus. Technetium: Chemistry and radiopharmaceutical applications. Wiley-VCH, 2000.

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Pecorale, Andrea. Essence of the PET Radiopharmaceutical Business. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-97937-9.

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Wieland, Donald M., Michael C. Tobes, and Thomas J. Manger, eds. Analytical and Chromatographic Techniques in Radiopharmaceutical Chemistry. Springer New York, 1986. http://dx.doi.org/10.1007/978-1-4612-4854-5.

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Mather, Stephen J., ed. Current Directions in Radiopharmaceutical Research and Development. Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-009-1768-2.

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J, Mather Stephen, ed. Current directions in radiopharmaceutical research and development. Kluwer Academic Publishers, 1996.

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Book chapters on the topic "Radiopharmaceutical"

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Floresco, Stan, Robert Kessler, Ronald L. Cowan, et al. "Radiopharmaceutical." In Encyclopedia of Psychopharmacology. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_883.

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Nahler, Gerhard. "radiopharmaceutical." In Dictionary of Pharmaceutical Medicine. Springer Vienna, 2009. http://dx.doi.org/10.1007/978-3-211-89836-9_1178.

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Hamilton, David. "Radiopharmaceutical." In Diagnostic Nuclear Medicine. Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-662-06588-4_20.

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Ermert, Johannes, Martina Benešová, Verena Hugenberg, et al. "Radiopharmaceutical Sciences." In Clinical Nuclear Medicine. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-39457-8_2.

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Piel, Markus, and Frank Rösch. "Radiopharmaceutical Chemistry." In Molecular Imaging in the Clinical Neurosciences. Humana Press, 2012. http://dx.doi.org/10.1007/7657_2012_41.

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Holzwarth, Uwe. "Radiopharmaceutical Production." In Radiation Physics for Nuclear Medicine. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-11327-7_6.

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Mankoff, David. "Why Nuclear Imaging and Radiotherapy?" In Radiopharmaceutical Chemistry. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-98947-1_1.

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Kamkaew, Anyanee, Emily B. Ehlerding, and Weibo Cai. "Nanoparticles as Radiopharmaceutical Vectors." In Radiopharmaceutical Chemistry. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-98947-1_10.

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Antoni, Gunnar. "The Radiopharmaceutical Chemistry of Carbon-11: Basic Principles." In Radiopharmaceutical Chemistry. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-98947-1_11.

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Pichler, Verena, Neydher Berroterán-Infante, Marius Ozenil, Sarah Pfaff, Cécile Philippe, and Wolfgang Wadsak. "The Radiopharmaceutical Chemistry of Carbon-11: Tracers and Applications." In Radiopharmaceutical Chemistry. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-98947-1_12.

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Conference papers on the topic "Radiopharmaceutical"

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Chu, H., R. Heller, J. Cates, S. Lee, and J. S. Lee. "Comparison of Silicon and Scintillator Radiopharmaceutical Trackers by Monte Carlo Simulation." In 2024 IEEE Nuclear Science Symposium (NSS), Medical Imaging Conference (MIC) and Room Temperature Semiconductor Detector Conference (RTSD). IEEE, 2024. http://dx.doi.org/10.1109/nss/mic/rtsd57108.2024.10656195.

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Miyaoka, R. S., and W. C. Hunter. "The Whole-body Activity Monitor (WhAM) for Personalization of Radiopharmaceutical Therapies (RPT)." In 2024 IEEE Nuclear Science Symposium (NSS), Medical Imaging Conference (MIC) and Room Temperature Semiconductor Detector Conference (RTSD). IEEE, 2024. http://dx.doi.org/10.1109/nss/mic/rtsd57108.2024.10654976.

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Ryhiner, M., Y. Song, C. V. Gomes Ferreira, et al. "A Mathematical Model for the Investigation of Combined Treatment of Radiopharmaceutical Therapy and PARPi." In 2024 IEEE Nuclear Science Symposium (NSS), Medical Imaging Conference (MIC) and Room Temperature Semiconductor Detector Conference (RTSD). IEEE, 2024. http://dx.doi.org/10.1109/nss/mic/rtsd57108.2024.10658633.

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Yartey, Miriam N. Y., and Alfred O. Ankrah. "Overview of Radiopharmaceutical Therapy in Ghana." In Abstracts for the 18th International Conference on Radiopharmaceutical Therapy (ICRT). Thieme Medical and Scientific Publishers Pvt. Ltd., 2023. http://dx.doi.org/10.1055/s-0043-1769984.

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"ASTATINE-211 AS AN EMERGING RADIOISOTOPE FOR TARGETED ALPHA THERAPY (TAT)." In RAD Conference. RAD Centre, Niš, Serbia, 2024. https://doi.org/10.21175/radproc.2024.11.

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Cancer treatment presents complex challenges, necessitating the exploration of innovative approaches for diagnosis and therapy. Among emerging prospects, Radiopharmaceutical Therapy (RPT) using α- emitting radionuclides has gained notable attention. This article provides an overview of the literature on Targeted Alpha Therapy (TAT), explicitly focusing on astatine-211 (211At). It discusses methodologies for labeling 211At, along with the associated challenges, to contribute to a deeper understanding of its potential role in TAT. The physical properties of 211At make it a promising candidate fo
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Khabirova, Sofia, Gleb Aleshin, Evgeny Anokhin, Anna Shchukina, and Anastasia Zubenko. "Radiolabelled strontium hexaferrite nanoparticles for radiopharmaceutical applications." In RAD Conference. RAD Centre, 2021. http://dx.doi.org/10.21175/rad.abstr.book.2021.23.5.

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Boisson, F., V. Bekaert, Z. El Bitar, J. Steibel, D. Huss, and D. Brasse. "1D gamma counting approach to study radiopharmaceutical kinetics." In 2008 IEEE Nuclear Science Symposium and Medical Imaging conference (2008 NSS/MIC). IEEE, 2008. http://dx.doi.org/10.1109/nssmic.2008.4774313.

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Lemesios, Christos, Panayiotis Hadjitheodorou, Loizos Koutsantonis, Alexis Vrachimis, Nikos Zampoglou, and Costas N. Papanicolas. "Improved PET Image Reconstruction for reduced radiopharmaceutical dose." In 2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC). IEEE, 2020. http://dx.doi.org/10.1109/nss/mic42677.2020.9507809.

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Borangiu, Theodor, Silviu Raileanu, Ecaterina Oltean, Andrei Silisteanu, and Iulia Iacob. "Service-oriented, holonic environment control of radiopharmaceutical production facilities." In 2017 21st International Conference on System Theory, Control and Computing (ICSTCC). IEEE, 2017. http://dx.doi.org/10.1109/icstcc.2017.8107011.

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Widyasari, Eva Maria, Auliya Nurasatidah Hudriyah, Witri Nuraeni, Teguh Hafiz Ambar Wibawa, and Maula Eka Sriyani. "Physicochemical characteristic of 99mTc-DTPA-deoxy-D-glucose radiopharmaceutical." In 2ND INTERNATIONAL CONFERENCE ON ENERGETICS, CIVIL AND AGRICULTURAL ENGINEERING 2021 (ICECAE 2021). AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0110202.

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Reports on the topic "Radiopharmaceutical"

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Lilley, Laura Margaret. Radiopharmaceutical Antibiotics. Office of Scientific and Technical Information (OSTI), 2018. http://dx.doi.org/10.2172/1458965.

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Srivastava, P. (Radiopharmaceutical chemistry). Office of Scientific and Technical Information (OSTI), 1988. http://dx.doi.org/10.2172/6870734.

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Buchsbaum, Donald J. Radiopharmaceutical and Gene Therapy Program. Office of Scientific and Technical Information (OSTI), 2006. http://dx.doi.org/10.2172/875908.

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Srivastava, P. (Radiopharmaceutical and chemotherapeutic drug technology). Office of Scientific and Technical Information (OSTI), 1988. http://dx.doi.org/10.2172/6808895.

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Cooper, M., and R. Beck. Quantitative studies in radiopharmaceutical science. Office of Scientific and Technical Information (OSTI), 1989. http://dx.doi.org/10.2172/5185924.

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Mangner, Thomas J. Radiopharmaceutical Tracers for Neural Progenitor Cells. Office of Scientific and Technical Information (OSTI), 2006. http://dx.doi.org/10.2172/892567.

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Kilbourn, Michael, R. Simplification of Methods for PET Radiopharmaceutical Syntheses. Office of Scientific and Technical Information (OSTI), 2011. http://dx.doi.org/10.2172/1032061.

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Som, P., and D. F. Sacker. Whole-body autoradiographic microimaging: Applications in radiopharmaceutical and drug research. Office of Scientific and Technical Information (OSTI), 1991. http://dx.doi.org/10.2172/10136272.

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Cooper, M., and R. N. Beck. Nuclear medicine and imaging research (quantitative studies in radiopharmaceutical science). Office of Scientific and Technical Information (OSTI), 1992. http://dx.doi.org/10.2172/7236116.

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Som, P., and D. F. Sacker. Whole-body autoradiographic microimaging: Applications in radiopharmaceutical and drug research. Office of Scientific and Technical Information (OSTI), 1991. http://dx.doi.org/10.2172/5616107.

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