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Dissertations / Theses on the topic 'Radiopharmaceutical'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Suliman, Zaahirah. "A qualitative evaluation on the appropriateness of the current regulatory guidelines, on the manufacture of medicines within the radiopharmaceutical industry." University of the Western cape, 2016. http://hdl.handle.net/11394/5658.

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Magister Pharmaceuticae - MPharm<br>The purpose of this research thesis, is to evaluate the appropriateness of the current regulatory guidelines on the manufacture of medicinal products within the radiopharmaceutical industry. The manufacture of radiopharmaceuticals is governed by two main regulatory bodies. The regulatory authority responsible for the governance of the pharmaceutical product has the primary objective of ensuring the safety, efficacy and purity of the products manufactured, while the nuclear regulator has the responsibility of ensuring that the products used and manufactured a

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2

Puncher, M. "Microautoradiography in radiopharmaceutical research." Thesis, University of Kent, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281658.

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3

Heslop, Julia M. "Copper complexes with potential radiopharmaceutical applications." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418800.

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4

Allan, Cheryll Clare. "Synthesis of rigid tetraazamacrocycles : radiopharmaceutical applications." Thesis, University of Hull, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417150.

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5

Walker, Paul Saunders. "New chelating systems for radiopharmaceutical diagnosis." Thesis, University of Southampton, 1997. https://eprints.soton.ac.uk/361137/.

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This thesis concerns the design of novel binding agents for radioisotopes having potential application in radiopharmaceutical imaging systems. The first section reviews the currently available methods of radioimaging with particular emphasis on the limitations of the pharmaceutical reagents currently used for this important medical diagnostic tool. The main focus of the work concerns: (i) the design and study of a particular class of novel radiopharmaceutical hosts based on a well-established group of polydentate ligands, the propylene amine oximes (PnAOs); and (ii) the evaluation of various t

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6

Mora, Ramirez Erick. "Radiopharmaceutical dosimetry in targeted radionuclide therapy." Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30012.

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La médecine nucléaire est une spécialité médicale dont l'une des applications est l'étude de la physiologie des organes et du métabolisme de divers types de tumeurs. Les produits pharmaceutiques liés à un isotope radioactif (médicament radio-pharmaceutique, MRP) sont étudiés en préclinique avant d'être utilisés chez l'homme. Les rongeurs sont généralement utilisés pour étudier la bio-cinétique du traceur dans un groupe d'organes prédéfinis. L'extrapolation des résultats de ces études de l'animal à l'homme permet d'avoir une estimation du comportement des MRP et de l'irradiation délivrée en cli

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7

Easson, Morag Ann Maccall. "Synthesis of tailored ligands for radiopharmaceutical applications." Thesis, Durham University, 1997. http://etheses.dur.ac.uk/4916/.

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An important aspect of clinical imaging techniques involves the use of complexed gamma or positron-emitting radionuclides, e.g. (^99m)Tc(γ, t1/2 = 6.02 h, 141 keV) for Single Photon Emission Tomography (SPET), (^62)Cu (β(^+),t1/2 = 9.74 min, 1.315 MeV) for Positron Emission Tomography (PET). With such radiopharmaceuticals in mind, two new classes of acyclic tetradentate ligands have been synthesised, featuring an N(_2)S(_2) donor system. This array of donor atoms is particularly attractive for its 'soft’ metal preference, favouring the complexation of radionuclides such as (^64)Cu and (^99m)Tc

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8

Tran, Anh My. "Synthesis of bifunctional chelates for potential radiopharmaceutical applications." Thesis, University of Essex, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247010.

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9

Morgan, G. F. E. "Chemical and radiopharmaceutical studies of technetium containing complexes." Thesis, Loughborough University, 1987. https://dspace.lboro.ac.uk/2134/13763.

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The work described within this thesis takes the form of several different but related projects. The radionuclide, 99mTc, is widely used in nuclear medicine departments and researched in many laboratories throughout the world today and it is the intention of this thesis to contribute to the growing library of knowledge in this field. In chapter three, the technetium complex of tiron, a disulphonato derivative of catechol, is assessed for its radiopharmaceutical efficacy using both animal and human models. The no carrier added [ 99mTc] Tctiron preparation appears to form a single radiochemical s

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10

Seifert, S., and J. Van Den Hoff. "Annual Report 2004 - Institute of Bioinorganic and Radiopharmaceutical Chemistry." Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-28695.

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11

Seifert, S., and H. Spies. "Annual Report 2003 - Institute of Bioinorganic and Radiopharmaceutical chemistry." Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-28959.

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12

Johannsen, Bernd, and Sepp Seifert. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 2002." Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-29271.

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13

Johannsen, Bernd, and Sepp Seifert. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 2001." Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-29488.

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14

Seifert, Sepp, and Bernd Johannsen. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 2000." Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-29716.

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15

Johannsen, Bernd, and Sepp Seifert. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 1997." Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-30891.

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16

Seifert, Sepp, and Bernd Johannsen. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 1996." Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-31238.

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17

Seifert, Sepp, and Bernd Johannsen. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 1995." Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-31653.

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18

Johannsen, Bernd. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 1994." Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-32143.

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19

Johannsen, Bernd. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 1993." Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-32438.

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20

Johannsen, Bernd. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 1992." Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-32587.

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21

Seifert, S., and J. Van Den Hoff. "Annual Report 2004 - Institute of Bioinorganic and Radiopharmaceutical Chemistry." Forschungszentrum Rossendorf, 2005. https://hzdr.qucosa.de/id/qucosa%3A21696.

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22

Seifert, S., and H. Spies. "Annual Report 2003 - Institute of Bioinorganic and Radiopharmaceutical chemistry." Forschungszentrum Rossendorf, 2004. https://hzdr.qucosa.de/id/qucosa%3A21722.

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23

Johannsen, Bernd, and Sepp Seifert. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 2002." Forschungszentrum Rossendorf, 2003. https://hzdr.qucosa.de/id/qucosa%3A21754.

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24

Johannsen, Bernd, and Sepp Seifert. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 2001." Forschungszentrum Rossendorf, 2002. https://hzdr.qucosa.de/id/qucosa%3A21775.

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25

Johannsen, Bernd, and Sepp Seifert. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 1997." Forschungszentrum Rossendorf, 1997. https://hzdr.qucosa.de/id/qucosa%3A21916.

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26

Seifert, Sepp, and Bernd Johannsen. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 1996." Forschungszentrum Rossendorf, 1997. https://hzdr.qucosa.de/id/qucosa%3A21950.

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27

Seifert, Sepp, and Bernd Johannsen. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 1995." Forschungszentrum Rossendorf, 1996. https://hzdr.qucosa.de/id/qucosa%3A21992.

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28

Johannsen, Bernd. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 1994." Forschungszentrum Rossendorf, 1995. https://hzdr.qucosa.de/id/qucosa%3A22041.

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29

Johannsen, Bernd. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 1993." Forschungszentrum Rossendorf, 1994. https://hzdr.qucosa.de/id/qucosa%3A22070.

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30

Johannsen, Bernd. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 1992." Forschungszentrum Rossendorf, 1993. https://hzdr.qucosa.de/id/qucosa%3A22085.

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31

Seifert, Sepp, and Bernd Johannsen. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 2000." Forschungszentrum Rossendorf, 2001. https://hzdr.qucosa.de/id/qucosa%3A21798.

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32

Johannsen, B., and S. Seifert. "Institute of Bioinorganic and Radiopharmaceutical Chemistry, Report July - December 1999." Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-30041.

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33

Shore, Benjamin. "The synthesis and characterisation of fluorescent compounds of radiopharmaceutical relevance." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491967.

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This thesis presents the results of investigations into the synthesis, characterisation and biological behaviour of some radiophannaceutically-relevant copper, zinc and rhenium complexes. Chapter One gives a brief introduction into the uses of radiation in medicine. Emphasis is placed on complexes of rhenium, technetium and copper. Specific attention is paid to the importance of (thiosemicarbazonato)copper(II) complexes as hypoxia-selective PETimaging agents. Chapter Two presents the synthesis of a range of simple zinc thiosemicarbazone complexes, which are structurally analogous to some medic

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34

Bergin, Paul Michael. "Approaches to functionalised amine-based ligands for radiopharmaceutical delivery systems." Thesis, University of Southampton, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409852.

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35

Johannsen, B., and S. Seifert. "Institute of Bioinorganic and Radiopharmaceutical Chemistry, Report July - December 1999." Forschungszentrum Rossendorf, 2000. https://hzdr.qucosa.de/id/qucosa%3A21831.

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36

Vestergren, Eleonor. "Administered radiopharmaceutical activity and radiation dosimetry in paediatric nuclear medicine." Lund : Dept. of Radiation Physics, University og Göteborg, 1998. http://catalog.hathitrust.org/api/volumes/oclc/39776733.html.

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37

Lazarova, Neva. "Technetium and rhenium radiopharmaceutical agents in nuclear medicine design and synthesis /." Related electronic resource: Current Research at SU : database of SU dissertations, recent titles available full text, 2005. http://wwwlib.umi.com/cr/syr/main.

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38

Johannsen, Bernd, and S. Seifert. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Report January 1998 - Juni 1999." Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-30215.

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39

Johannsen, Bernd, and S. Seifert. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Report January 1998 - Juni 1999." Forschungszentrum Rossendorf, 1999. https://hzdr.qucosa.de/id/qucosa%3A21848.

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40

Mokaleng, Botshelo Brenda. "Preparation of a 5-HT2 selective receptor antagonist, 123I-5-I-R91150, for use in psychiatric disorders." Thesis, Stellenbosch : Stellenbosch University, 2010. http://hdl.handle.net/10019.1/4845.

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Thesis (MScMedSc)--Stellenbosch University, 2010.<br>ENGLISH ABSTRACT: Radiolabelled compounds have been widely used as investigative tools for psychiatric disorders using positron emission tomography (PET) or single photon emission tomography (SPECT) of the brain. In particular 123I-5-IR91150, a serotonin (5-HT) 2a antagonist, has been used for imaging the serotonergic system. The current study developed optimal radiolabelling and purification methods in our laboratory with the objective that it can provide 123I- 5-I-R91150 in sufficient quantity and of acceptable pharmaceutical quality

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41

Johnston, Alexander Henderson. "Novel approaches to dendrimer based radiopharmaceutical imaging agents and drug delivery systems." Thesis, University of Southampton, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.582662.

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The work reported in this thesis details two novel approaches towards the use of poly(amidoamine) (PAMAM) dendrimers for medicinal applications. The introduction contains a brief overview on the synthesis and properties of dendrimers, focusing in particular on PAMAM dendrimers and the growing interest in their use as polymer therapeutics. The second part of the introduction contains an overview of the role of Tc99m in nuclear medicine. The final part of the introduction gives an explanation of the genetic disorder, cystic fibrosis, concentrating on the degenerative lung disease associated with

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42

Rossouw, Daniel Du Toit. "Synthesis and radiochemical stability evaluation of radiopharmaceutical compounds containing radioiodinated prosthetic groups." Thesis, Stellenbosch : Stellenbosch University, 2004. http://hdl.handle.net/10019.1/50113.

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Thesis (PhD)--Stellenbosch University, 2004.<br>ENGLISH ABSTRACT: A study was undertaken to investigate the radiochemical stability of the βiodoethoxyl moiety, a relatively novel prosthetic group employed in radiopharmaceutical chemistry, in which an oxygen atom in a β-position relative to the radioiodine atom has a stabilising effect on the aliphatic carbon-iodine bond. The investigation was started as a pilot study by synthesising various model compounds containing a β-radioiodoethoxyl moiety, as well as two reference compounds lacking such a moiety. The purpose was to determine the in

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43

Valentini, Serena <1990&gt. "Evaluation of the theranostic use of miRNAs in correlation to the radiopharmaceutical 64CuCl2 in glioblastoma." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amsdottorato.unibo.it/9814/1/Valentini_Serena_Tesi.pdf.

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B:Glioblastoma multiforme(GBM) is one of the most prevalent and aggressive malignant primary brain tumors in adult patients. 64CuCl2 is an innovative radiopharmaceutical investigated as theranostic agent in GBM patients. The therapeutic scheme is still under evaluation, therefore the research focused on the possibility of radioresistance development. The actors responsible for modulating radioresistance could be miRNAs, thus their potential use was investigated both in radioresistant cell lines and in GBM patients plasma samples. M:Radioresistant cell lines were generated by exposing U87MG, U3

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44

Clunie, Gavin Peter Ross. "The application of samarium-153 particulate hydroxyapatite a new particulate radiopharmaceutical for the treatment of chronic synovitis." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244052.

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45

Dantas, Danielle Maia. "Toxicidade aguda e subaguda do radiofármaco 18F-FDG." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-24102013-092837/.

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Antes de se iniciar os estudos clínicos de uma nova droga, é necessário realizar uma bateria de testes de segurança, para avaliar o risco humano. Os radiofármacos como qualquer outra nova droga, devem ser testados levando em conta sua especificidade, duração de tratamento e principalmente a toxicidade de ambas as partes, a molécula não marcada e a sua radioatividade em si, além das impurezas provindas da radiólise. Órgãos regulatórios como o Food and Drug Administration-EUA (FDA) e a Agência de Medicina Européia (EMEA), estabelecem guias para a regulamentação de produção e pesquisas de radiofá

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46

Webb, Gordon A. "Radiopharmaceutical applications of technetium 3-oxy-4-pyrones and 3-oxy-4-pyridinones and gallium 3-oxy-4-pyridinones." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/29206.

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Ammonium pertechnetate [NH₄][TⅽO₄] was reacted with the following ligands via the reduction route: 3-hydroxy-2-methyl-4-pyrone (maltol), 5-hydroxy-2-hydroxymethyl-4-pyrone (kojic acid), 3-hydroxy-2-methyl-4-pyridinone (Hmpp), 3-hydroxy-l,2-dimethyl-4-pyridinone (Hdpp), 3-hydroxy-2-methyl-l-hexyl-4-pyridinone (Hmhpp), 3-hydroxy-2-methyl-l-undecanato-4-pyridinone (Hmupp), and β-[N-(3-hydroxy-4-pyridinone)]-α-aminopropionic acid (l-mimosine). The products from the reduction route were characterized by mass spectrometry, infrared spectrometry, ultraviolet spectroscopy, and conductivity‧measurement

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47

Barkhausen, Christoph [Verfasser], Andreas [Akademischer Betreuer] Türler, and Grafenstein Ulrich [Akademischer Betreuer] Boesl-von. "Production of non carrier added (n.c.a.) 177Lu for radiopharmaceutical applications / Christoph Barkhausen. Gutachter: Ulrich Boesl-von Grafenstein. Betreuer: Andreas Türler." München : Universitätsbibliothek der TU München, 2011. http://d-nb.info/1019587458/34.

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48

Lima, Mariana da Cunha Lopes de. "Etilenodicisteína-99m Tc é um radiofármaco mais efetivo que o ácido dietilenotriaminopentacético-99m Tc para excluir obstrução em pacientes com dilatação das vias urinárias." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308695.

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Orientador: Celso Dario Ramos<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-16T23:06:04Z (GMT). No. of bitstreams: 1 Lima_MarianadaCunhaLopesde_D.pdf: 5311684 bytes, checksum: 4e6a0ba6a1a013ca5e9a995b127a5a95 (MD5) Previous issue date: 2010<br>Resumo: A diferenciação entre obstrução mecânica e dilatação das vias urinárias sem obstrução é extremamente importante para se determinar o tratamento correto. O objetivo deste trabalho foi avaliar a utilidade do estudo renal dinâmico com diurético (ERDD) com L,L-etilenodi

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49

Almeida, Jamille da Silveira. "Estudo das impurezas radioativas gama emissoras presentes nos radiofármacos produzidos no IPEN-CNEN/SP." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-10082017-113643/.

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Este trabalho tem como objetivo investigar a concentração de impurezas radioativas gama emissoras presentes nas soluções dos radiofármacos produzidos no Instituto de Pesquisas Energéticas e Nucleares - IPEN em São Paulo. Para que este radiofármaco possa ser utilizado adequadamente, sua qualidade deve ser avaliada de acordo com os procedimentos estabelecidos de acordo com os \"Requisitos Gerais para a Competência de Laboratórios de Teste e Calibração\", ISO / IEC 17025: 2005 e pelas \"Boas Práticas de Fabricação\" (BPF), controladas pela ANVISA (Agência Nacional de Vigilância Sanitária), no Bra

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50

Zanette, Camila. "Estudo da produção do radiofármaco FLT-18F em sistema automatizado: contribuição para a avaliação do processo." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-04072013-140325/.

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O radiofármaco FLT-18F é um análogo do nucleosídeo timidina e um promissor marcador da proliferação tumoral para imagens em PET. A síntese deste radiofármaco não é simples e, muitas vezes, apresenta baixos rendimentos. Este radiofármaco já vem sendo estudado há alguns anos, porém, não há produção, nem estudos clínicos, no Brasil. O estudo do processo produtivo e a sua adequação às diretrizes de Boas Práticas de Fabricação (ANVISA) são de extrema importância. Este trabalho teve como objetivo estudar a síntese deste radiofármaco, avaliar os métodos de controle de qualidade que serão utilizados n

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