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Journal articles on the topic 'Radiopharmaceutical'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Budinský, Michal, Petr Vyšinský, Zdeněk Řehák, and Jan Adam. "Experience with the Preparation of ⁶⁸Ga-PSMA-11." Chemické listy 116, no. 12 (2022): 746–50. http://dx.doi.org/10.54779/chl20220746.

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The radiopharmaceutical 68Ga-PSMA-11 represents a radiopharmaceutical drug without marketing authorization for the prostate cancer diagnosis in a specific treatment program. In respect of the radiopharmaceutical technology, the difficultness of the preparation of 68Ga-PSMA-11 is comparable to that of conventional radiopharmaceuticals.

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Budinský, Michal, and Vendula Janků. "Porovnání přípravy radiofarmaka 68Ga-PSMA-11 na dvou českých pracovištích." Česká a slovenská farmacie 72, no. 3 (2023): 125–31. http://dx.doi.org/10.5817/csf2023-3-125.

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Radiopharmaceutical 68Ga-PSMA-11 is one of the newest positron radiopharmaceuticals available for nuclear medicine departments in the Czech Republic. The radiopharmaceutical preparation can be carried out manually or instrumentally using modules for synth

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Budinský, Michal, Petr Vyšinský, Stanislav Synek, Beatrix Bencsiková, Iveta Selingerová, and Zdeněk Řehák. "68Ga-DOTATOC." Česká a slovenská farmacie 70, no. 4 (2021): 136–41. http://dx.doi.org/10.5817/csf2021-4-136.

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The radiopharmaceutical 68Ga-DOTATOC represents the latest radiopharmaceutical in the diagnosis of a neuroendocrine tumor with somatostatin receptor overexpression. Technological and economic difficulties of preparing and quality control of the radiopharmaceutical limit its use to specialised departments. Background of the department with rich experience with radiopharmaceuticals for positron emission tomography allows handling more difficult 68Ga-radiopharmacy and may increase and improve the care of oncology patients.

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Kunos, Charles A., and Jacek Capala. "National Cancer Institute Programmatic Collaboration for Investigational Radiopharmaceuticals." American Society of Clinical Oncology Educational Book, no. 38 (May 2018): 488–94. http://dx.doi.org/10.1200/edbk_200199.

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Radiopharmaceutical therapies have provided an attractive therapeutic approach since the introduction of 131I to treat thyroid cancer. New insights in cancer biology and radiochemistry have brought radiopharmaceuticals to the leading edge of oncology clinical research. National Cancer Institute (NCI) programs watch for new radiopharmaceutical breakthroughs that should be used to treat patients with unmet therapeutic needs. Such efforts occur through leveraged partnerships between NCI’s Cancer Therapy Evaluation Program and its Radiation Research Program. If groundbreaking discoveries are made,

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SAW, MAUNG MAUNG. "MEDICINAL RADIOPHARMACEUTICAL CHEMISTRY OF METAL RADIOPHARMACEUTICALS." COSMOS 08, no. 01 (2012): 11–81. http://dx.doi.org/10.1142/s0219607712300044.

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Metal complexes have been used as medicinal compounds. Metals have advantageous features over organic compounds. Significant applications of metal complexes are in the field of nuclear medicine. Radiopharmaceuticals are drugs containing radioisotopes used for diagnostic and therapeutic purposes. The generalized targeting strategy for molecular imaging probe consists of three essential parts: (i) reporter unit or payload, (ii) carrier, and (iii) targeting system. Medicinal radiopharmaceutical chemistry pays special consideration to radioisotopes, as a reporter unit for diagnostic application or

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Kunos, Charles A., and Rita Abdallah. "Financial Toxicity Encountered in Therapeutic Radiopharmaceutical Clinical Development for Ovarian Cancer." Pharmaceuticals 13, no. 8 (2020): 181. http://dx.doi.org/10.3390/ph13080181.

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Financial toxicity or the debt a cancer survivor incurs from the costs of their medical cancer care is an understudied aspect in the clinical development of experimental therapeutic agents. The United States National Cancer Institute (NCI) Cancer Therapy Evaluation Program studies experimental therapeutic agents like radiopharmaceuticals in both early and late phase trials, which provide opportunities to comprehend more clearly the possible sources of financial toxicity incurred by cancer survivors. We reviewed the academic scholarship describing fiscal and social costs involved in the develop

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Ganaie, Sameer Ahmad, Ruqiya Ramzan, and Mubashir Habib. "Radiopharmaceuticals-Emerging Trends and Applications in diagnostic Imaging and Therapy." International Journal of Health Sciences and Research 15, no. 2 (2025): 85–99. https://doi.org/10.52403//ijhsr.20250211.

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The landscape of nuclear medicine is undergoing a profound transformation, driven by the rapid evolution of radiopharmaceuticals. These innovative agents are redefining the boundaries of diagnostic imaging and targeted therapy, offering unprecedented opportunities for precision medicine. This comprehensive review article provides a cutting-edge overview of the emerging trends and applications of radiopharmaceuticals in diagnostic imaging and therapy. We delve into the latest advancements in radiopharmaceutical design, synthesis, and application, including the development of novel isotopes, pep

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Koźmiński, Przemysław, Paweł Krzysztof Halik, Raphael Chesori, and Ewa Gniazdowska. "Common Shortcomings in Study on Radiopharmaceutical Design Research: A Case Study of 99mTc-Labelled Methotrexate." Molecules 26, no. 19 (2021): 5862. http://dx.doi.org/10.3390/molecules26195862.

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The aim of the work carried out was to draw attention to shortcomings that often appear at the stage of designing new radiopharmaceuticals. Based on a case study of 99mTc-labelled methotrexate, this article describes frequent mistakes or misconceptions present not only in the referenced studies, but also in numerous radiopharmaceutical studies. The recommendations provided in this article highlight fundamental aspects of the credibility of radiopharmaceutical scientific research leading to the reliable results.

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Chiang, Ping Fang. "Development of INER-PP-F11N as the radionuclide theragnostics agent against cholecystokinin B receptor-overexpressed tumors." JCO Global Oncology 9, Supplement_1 (2023): 164. http://dx.doi.org/10.1200/go.2023.9.supplement_1.164.

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164 Background: We aimed to evaluate an albumin affinity structure-containing radiopharmaceutical agents INER-PP-F11N-1 and INER-PP-F11N-2 for diagnostic/therapeutic the CCK2R-overexpressed cancers. Methods: We developed the radionuclide labeled In-111/Lu-177-INER-PP-F11N radiopharmaceuticals in comparison with the current PP-F11N to investigate the radiochemical purity, SPECT/CT imaging, bio-distribution, and therapeutic responses in CCK2R-expressing tumor xenograft mice. Results: The radiochemical purity of In-111/Lu-177-INER-PP-F11N radiopharmaceuticals reached more than 90% after 144 hours

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Kleynhans, Janke, Hendrik Gerhardus Kruger, Theunis Cloete, Jan Rijn Zeevaart, and Thomas Ebenhan. "In Silico Modelling in the Development of Novel Radiolabelled Peptide Probes." Current Medicinal Chemistry 27, no. 41 (2020): 7048–63. http://dx.doi.org/10.2174/0929867327666200504082256.

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This review describes the usefulness of in silico design approaches in the design of new radiopharmaceuticals, especially peptide-based radiotracers (including peptidomimetics). Although not part of the standard arsenal utilized during radiopharmaceutical design, the use of in silico strategies is steadily increasing in the field of radiochemistry as it contributes to a more rational and scientific approach. The development of new peptide-based radiopharmaceuticals as well as a short introduction to suitable computational approaches are provided in this review. The first section comprises a co

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Vidal, Aurelien, Cécile Bourdeau, Mathieu Frindel, et al. "ARRONAX Cyclotron: Setting up of In-House Hospital Radiopharmacy." BioMed Research International 2020 (March 10, 2020): 1–6. http://dx.doi.org/10.1155/2020/1572841.

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Whilst radiopharmaceuticals have an important role to play in both imaging and treatment of patients, most notably cancer patients, nuclear medicine and radiopharmacy are currently facing challenges to create innovative new drugs. Traditional radiopharmaceutical manufacture can be considered as either a routine hospital production or a large-scale industrial production. The gap between these two practices has meant that there is an inability to supply innovative radiopharmaceuticals for use at the local level for mono- or multicentric clinical trials with satisfactory quality and safety specif

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Kunos, Charles A., Molly E. Martin, Michalis F. Georgiou, Russ A. Kuker, and Aman Chauhan. "Leveraging Programmatic Collaboration for a Radiopharmaceutical Clinic." Cancers 16, no. 7 (2024): 1396. http://dx.doi.org/10.3390/cancers16071396.

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Radiation oncologists, radiopharmacists, nuclear medicine physicians, and medical oncologists have seen a renewed clinical interest in radiopharmaceuticals for the curative or the palliative treatment of cancer. To allow for the discovery and the clinical advancement of targeted radiopharmaceuticals, these stakeholders have reformed their trial efforts and remodeled their facilities to accommodate the obligations of a program centered upon radioactive investigational drug products. Now considered informally as drugs and not beam radiotherapy, radiopharmaceuticals can be more easily studied in

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13

Gomes, Maria Luisa, Marcia B. Nunes de Oliveira, and Mario Bernardo-Filho. "Drug interaction with radiopharmaceuticals: effect on the labeling of red blood cells with technetium-99m and on the bioavailability of radiopharmaceuticals." Brazilian Archives of Biology and Technology 45, spe (2002): 143–49. http://dx.doi.org/10.1590/s1516-89132002000500020.

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The evidence that natural and synthetic drugs can affect radiolabeling or bioavailability of radiopharmaceuticals in setting of nuclear medicine clinic is already known. However, this drug interaction with radiopharmaceuticals (DIR) is not completely understood. Several authors have described the effect of drugs on the labeling of blood elements with technetium-99m (99mTc) and on the biodistribution of radiopharmaceuticals. When the DIR is known, if desirable or undesirable, the natural consequence is a correct diagnosis. However, when it is unknown, it is undesirable and the consequences are

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Thresnayu Cahayaputri, Olivia, Agnes Sprakezia Lubis, Raditya Faradina, and Aditya Tri Oktaviana. "Analisis Perhitungan Nilai Biodistribusi Tc-99m Perteknetat Pada Pasien Hipertiroid." JRI (Jurnal Radiografer Indonesia) 7, no. 1 (2024): 12–18. http://dx.doi.org/10.55451/jri.v7i1.269.

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Background : The distribution value of the Tc-99m radiopharmaceutical in 02 hyperthyroid patients at a Jakarta Hospital was calculated to determine the absorption dose value of the radiopharmaceutical in the thyroid organ. Thyroid scan is a type of examination carried out on patients using a SPECT aircraft equipped with a dual gamma camera detector. The radiopharmaceutical Tc-99m perteknetate is injected into the patient's body via an intravenous line at 3-5 mCi with an imaging time of 15 minutes. Biodistribution determination analysis can be calculated using the ROI technique. Method : This s

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Santos-Oliveira, Ralph, Sheila W. Smith, and Ana Maria A. Carneiro-Leão. "Radiopharmaceuticals drug interactions: a critical review." Anais da Academia Brasileira de Ciências 80, no. 4 (2008): 665–75. http://dx.doi.org/10.1590/s0001-37652008000400008.

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Radiopharmaceuticals play a critical role in modern medicine primarily for diagnostic purposes, but also for monitoring disease progression and response to treatment. As the use of image has been increased, so has the use of prescription medications. These trends increase the risk of interactions between medications and radiopharmaceuticals. These interactions which have an impact on image by competing with the radiopharmaceutical for binding sites for example can lead to false negative results. Drugs that accelerate the metabolism of the radiopharmaceutical can have a positive impact (i.e. sp

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16

Kowalsky, Richard J., and James A. Ponto. "A Basic Overview of Radiopharmaceuticals and Their Relationship to Nuclear Pharmacy Practice." Journal of Pharmacy Practice 2, no. 3 (1989): 139–47. http://dx.doi.org/10.1177/089719008900200302.

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Radiopharmaceuticals are radioactive drugs used to diagnose and treat disease with radiation. Following patient administration of a radiopharmaceutical, γ-camera images are made of its localization and distribution within specific organs. The images obtained provide information that the nuclear medicine physician can use to make a diagnosis. Dynamic imaging studies provide functional information through measurement of the rates of accumulation and removal of the radiopharmaceutical by the organ. Static images provide morphologic information regarding organ size, shape, and position, the presen

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Chipiga, L. A., D. D. Lavreshov, A. V. Vodovatov, et al. "Experimental Assessment of Absorbed Doses in Pathological Lesions during Radionuclide Therapy with 225Ac-PSMA-617 and 225Ac-DOTATATE." Meditsinskaya Fizika, no. 4 (December 29, 2023): 40–50. http://dx.doi.org/10.52775/1810-200x-2023-100-4-40-50.

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Development of radiopharmaceutical therapy treatment plans considering biokinetics of radiopharmaceuticals and individual features of patients is necessary for the provision of radiation safety of the patients and increase in the efficacy of treatment. Hence, it is necessary to assess the absorbed doses in lesions (targets). The current study presents the method for the assessment of the absorbed doses in lesions considering the biological effectiveness of exposure for the radiopharmaceutical therapy with 225Ac-PSMA-617 and 225Ac-DOTATATE. Assessment of the absorbed doses was performed based o

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Ahmadi Bidakhvidi, Niloefar, Karolien Goffin, Jeroen Dekervel, et al. "Peptide Receptor Radionuclide Therapy Targeting the Somatostatin Receptor: Basic Principles, Clinical Applications and Optimization Strategies." Cancers 14, no. 1 (2021): 129. http://dx.doi.org/10.3390/cancers14010129.

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Peptide receptor radionuclide therapy (PRRT) consists of the administration of a tumor-targeting radiopharmaceutical into the circulation of a patient. The radiopharmaceutical will bind to a specific peptide receptor leading to tumor-specific binding and retention. The only target that is currently used in clinical practice is the somatostatin receptor (SSTR), which is overexpressed on a range of tumor cells, including neuroendocrine tumors and neural-crest derived tumors. Academia played an important role in the development of PRRT, which has led to heterogeneous literature over the last two

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Poetzsch, Simon, Winfried Brenner, and Sarah Spreckelmeyer. "Are radiopharmaceuticals self-sterilizing? Radiation effect of gallium-68 and lutetium-177 on bacillus pumilus and staphylococcus succinus." Nuklearmedizin - NuclearMedicine 60, no. 06 (2021): 445–49. http://dx.doi.org/10.1055/a-1547-0628.

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Abstract Background For radiopharmaceuticals, aseptic preparation in combination with filtration is the most commonly used sterilizing method. In general, the production of radiopharmaceuticals needs to fulfil the requirements of good manufacturing practice. In the scope of this work, we focused on the positron emitter gallium-68 and on the therapeutically used beta- and gamma-emitter lutetium-177, as they are routinely used for in-house synthesis of radiopharmaceuticals in nuclear medicine departments. Our hypothesis is, that radiopharmaceuticals might be self-sterilizing due to a high radioa

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20

Rösch, Frank. "68Ge/68Ga Generators and 68Ga Radiopharmaceutical Chemistry on Their Way into a New Century." Journal of Postgraduate Medicine, Education and Research 47, no. 1 (2013): 18–25. http://dx.doi.org/10.5005/jp-journals-10028-1052.

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ABSTRACT 68Ga faces a renaissance initiated by the development of new 68Ge/68Ga radionuclide generators, sophisticated 68Ga radiopharmaceuticals, preclinical research and state-of-the-art clincial diagnoses via positron emission tomography/computed tomography (PET/CT). A new type of 68Ge/68Ga generator became commercially available in the first years of the 21st century, with eluates based on hydrochloric acid. These generators provided ‘cationic’ 68Ga instead of ‘inert’ 68Gacomplexes, and opened new pathways of MeIII radiopharmaceutical chemistry. The last decade has seen a 68Ga rush. Increas

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Halimah, Iim, Ahmad Ridwan, and Mukh Syaifudin. "UJI PRAKLINIS 99mTc-KANAMISIN SEBAGAI RADIOFARMAKA UNTUK PENCITRAAN INFEKSI." Jurnal Sains dan Teknologi Nuklir Indonesia 16, no. 1 (2015): 15. http://dx.doi.org/10.17146/jstni.2015.16.1.2364.

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ABSTRAK UJI PRAKLINIS 99mTc-KANAMISIN SEBAGAI RADIOFARMAKA UNTUK PENCITRA-AN INFEKSI. 99mTc-kanamisin merupakan salah satu radiofarmaka yang digunakan untuk mendiagnosis infeksi hingga ke bagian tubuh yang sangat dalam. Penelitian ini bertujuan untuk mendapatkan informasi mengenai karakteristik praklinis 99mTc-kanamisin meliputi toksisitas, sterilitas, pirogenitas, dan biodistribusi. Uji toksisitas dilakukan pada 5 ekor mencit yang diinjeksi 99mTc-kanamisin secara intra vena ekor, dilanjutkan dengan pengamatan sampai dengan 24 jam setelah injeksi. Hasil pengamatan menunjukkan bahwa 99mTc-kanam

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Benfante, Viviana, Alessandro Stefano, Muhammad Ali, et al. "An Overview of In Vitro Assays of 64Cu-, 68Ga-, 125I-, and 99mTc-Labelled Radiopharmaceuticals Using Radiometric Counters in the Era of Radiotheranostics." Diagnostics 13, no. 7 (2023): 1210. http://dx.doi.org/10.3390/diagnostics13071210.

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Radionuclides are unstable isotopes that mainly emit alpha (α), beta (β) or gamma (γ) radiation through radiation decay. Therefore, they are used in the biomedical field to label biomolecules or drugs for diagnostic imaging applications, such as positron emission tomography (PET) and/or single-photon emission computed tomography (SPECT). A growing field of research is the development of new radiopharmaceuticals for use in cancer treatments. Preclinical studies are the gold standard for translational research. Specifically, in vitro radiopharmaceutical studies are based on the use of radiopharm

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Giustiniani, Matteo, Umberto M. Musazzi, Paola Minghetti, and Donatella Paolino. "Radiopharmaceutical preparations: what are the legislative differences across Europe?" Journal of Pharmaceutical Health Services Research 12, no. 3 (2021): 363–68. http://dx.doi.org/10.1093/jphsr/rmab033.

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Abstract Objectives Radiopharmaceuticals, since the discovery of the first medical application of radioactive isotope, have been essential therapeutics for the diagnosis and treatment of numerous diseases. Since the Directive 2001/83/EC entered in force, European regulatory authorities have established a harmonised framework to set quality requirements for the industrial production of radiopharmaceuticals. However, little is known about the harmonisation of extemporaneous preparation of radiopharmaceutical preparations (EPRPs) among European countries. In this context, this study aims to provi

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Laferriere-Holloway, Travis S., Alejandra Rios, Giuseppe Carlucci, and R. Michael van Dam. "Rapid Purification and Formulation of Radiopharmaceuticals via Thin-Layer Chromatography." Molecules 27, no. 23 (2022): 8178. http://dx.doi.org/10.3390/molecules27238178.

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Before formulating radiopharmaceuticals for injection, it is necessary to remove various impurities via purification. Conventional synthesis methods involve relatively large quantities of reagents, requiring high-resolution and high-capacity chromatographic methods (e.g., semi-preparative radio-HPLC) to ensure adequate purity of the radiopharmaceutical. Due to the use of organic solvents during purification, additional processing is needed to reformulate the radiopharmaceutical into an injectable buffer. Recent developments in microscale radiosynthesis have made it possible to synthesize radio

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Kunos, Charles A., and Jacek Capala. "Radiopharmaceutical Switch Maintenance for Relapsed Ovarian Carcinoma." Pharmaceuticals 13, no. 10 (2020): 287. http://dx.doi.org/10.3390/ph13100287.

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Switch maintenance, or using alternative therapeutic agents that were not administered during a prior course of cancer treatment, has emerged as an active clinical research and regulatory agency-approvable path in the National Cancer Institute (NCI) Cancer Therapy Evaluation Program (CTEP) drug-development sequence. To better inform the design of therapeutic radiopharmaceutical trials, we reviewed academic scholarship discussing the clinical use of maintenance approaches to cancer treatment. Women with advanced-stage primary platinum-refractory or platinum-resistant ovarian carcinoma and their

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Atanasova Lazareva, Marija, Katerina Kolevska, Maja Chochevska, et al. "Aseptic process validation of [18F]Sodium Fluoride radiopharmaceutical in-house production." Macedonian Pharmaceutical Bulletin 68, no. 1 (2023): 37–42. http://dx.doi.org/10.33320/maced.pharm.bull.2022.68.01.004.

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Sodium fluoride ([18F]NaF) is a PET radiopharmaceutical for vizualization of the skeletal system and microcalcification. In the originally designed in-house method, [18F]NaF is recovered in aqueous solution after cyclotron irradiation, sterilized by passage through a 0.22 µm sterile filter and dispensed under aseptic conditions. To ensure the microbiological safety of drugs produced under aseptic conditions, validation of aseptic procedures is always recommended. This is essential for radiopharmaceuticals because most of them are released for administration before any sterility test can be com

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Poli, Michela, Mauro Quaglierini, Alessandro Zega, et al. "Risk Management in Good Manufacturing Practice (GMP) Radiopharmaceutical Preparations." Applied Sciences 14, no. 4 (2024): 1584. http://dx.doi.org/10.3390/app14041584.

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Risk assessment and management during the entire production process of a radiopharmaceutical are pivotal factors in ensuring drug safety and quality. A methodology of quality risk assessment has been performed by integrating the advice reported in Eudralex, ICHQ, and ISO 9001, and its validity has been evaluated by applying it to real data collected in 21 months of activities of 18F-FDG production at Officina Farmaceutica, CNR-Pisa (Italy) to confirm whether the critical aspects that previously have been identified in the quality risk assessment were effective. The analysis of the results of t

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Cairo, Stefano, Benedetta Arno, Mara Gilardi, et al. "Abstract 1827: Investigating the efficacy of 177-Lu therapeutics in a series of castrate resistant prostate cancer PDX models." Cancer Research 85, no. 8_Supplement_1 (2025): 1827. https://doi.org/10.1158/1538-7445.am2025-1827.

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Abstract Recent advancements in alpha and beta particle-emitting radiopharmaceuticals underscore the therapeutic potential of targeted radionuclide therapy, presenting a promising alternative for patients with advanced or metastatic disease where conventional treatments fall short. This field is pushing the boundaries of personalized medicine, allowing clinicians to tailor treatments to individual patients' genetic and molecular profiles, thereby improving outcomes. As translational research in radiopharmaceutical development progresses, it holds significant promise for redefining therapeutic

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Kolevska, Katerina, Marija Atanasova-Lazareva, Maja Chochevska, et al. "Design of feasibility study for the establishment of production of zirconium-89 radioisotope and implementation of of 89 Zr-radiopharmaceuticals in clinical practice in the Republic of North Macedonia." Archives of Public Health 15, no. 1 (2023): 95–104. http://dx.doi.org/10.3889/aph.2023.6090.

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In the last decade, the application of radiopharmaceuticals based on zirconium-89 (89Zr) radiometal has increased in both preclinical and clinical studies. The most frequently used 89Zr-radiopharmaceutical is 89Zr-trastuzumab used in the management of patients with breast cancer. Breast cancer is the most common cancer among women in North Macedonia and the most common cause of death from malignant neoplasms in this population; therefore, the introduction of new nuclear medicine procedures in these patients might improve the management of this disease. However,the introduction of radioisotope

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Laven, David L., and Stanley M. Shaw. "Detection of Drug Interactions Involving Radiopharmaceuticals: A Professional Responsibility of the Clinical Pharmacist." Journal of Pharmacy Practice 2, no. 5 (1989): 287–98. http://dx.doi.org/10.1177/089719008900200506.

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Radiopharmaceuticals are radioactive drugs used in nuclear medicine for diagnosis and, to some degree, for the treatment of disease. Considerable evidence exists in regard to the potential for altered biorouting of radiopharmaceuticals resulting from the coadministration of therapeutic drugs, as well as from certain disease states, nutritional conditions, and other factors. Altered biorouting may reduce the usefulness of the diagnostic test or provide misleading information. While retrospective identification of an altered biodistribution problem can be helpful, prospective detection is more d

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Bansode, Avinash H., Bhuvanachandra Bhoopal, Krishna Kumar Gollapelli, et al. "Binding Parameters of [11C]MPC-6827, a Microtubule-Imaging PET Radiopharmaceutical in Rodents." Pharmaceuticals 16, no. 4 (2023): 495. http://dx.doi.org/10.3390/ph16040495.

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Impairment and/or destabilization of neuronal microtubules (MTs) resulting from hyper-phosphorylation of the tau proteins is implicated in many pathologies, including Alzheimer’s disease (AD), Parkinson’s disease and other neurological disorders. Increasing scientific evidence indicates that MT-stabilizing agents protect against the deleterious effects of neurodegeneration in treating AD. To quantify these protective benefits, we developed the first brain-penetrant PET radiopharmaceutical, [11C]MPC-6827, for in vivo quantification of MTs in rodent and nonhuman primate models of AD. Mechanistic

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Wardaya, Asep Yoyo, Wahyu Setia Budi, Ali Khumaeni, Chorirul Anam, and Gani Gunawan. "Calculation of Absorption Dose Value using MIRD Method with Cobalt 57 MIBI for Four Body Organs." Journal of Physics and Its Applications 2, no. 1 (2019): 72. http://dx.doi.org/10.14710/jpa.v2i1.6180.

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MIRD has developed methods, assumptions, models, and mathematical formulae for estimating internal radiation doses from the injected radiopharmaceuticals into the body. This study aims to determine the radiopharmaceutical distribution of Cobalt 57 MIBI in patients identified as having breast cancer by using an oncology examination with MIRD method on 4 patient's organs with some time variations. The four organs of the patient's body are the heart, thyroid, kidney, and liver. The MIRD method developed to calculate the absorption dose of each organ is the product of the cumulative activity and t

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Xu, Tingting, Yingwei Wang, Zan Chen, et al. "Preparation, Characterization, and Preliminary Imaging Study of [188Re]Re-Ibandronate as a Novel Theranostic Radiopharmaceutical for Bone Metastasis." Contrast Media & Molecular Imaging 2022 (February 25, 2022): 1–13. http://dx.doi.org/10.1155/2022/7684076.

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Background. Bone is a common site of metastasis from a malignant tumor. Several radiopharmaceuticals are available to relieve bone pain in patients with cancer. However, every radiopharmaceutical has its own disadvantages, and there is still a need to investigate easily accessible and high bone affinity radiopharmaceuticals. Ibandronate (IBA) and 188Re were used for radiolabeling to develop and evaluate a novel type of bone-seeking radiopharmaceutical. Methods. The preparation conditions of [188Re]Re-IBA were investigated, and thin-layer chromatography was used to analyze radiochemical purity.

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Medvedeva, A. A., V. I. Chernov, O. D. Bragina, et al. "Diagnosis of sentinel lymph nodes in patients with cancer of the larynx and laryngopharynx using a new radiopharmaceutical based on technetium-99m-labeled gamma aluminum oxide." Bulletin of Siberian Medicine 22, no. 1 (2023): 65–72. http://dx.doi.org/10.20538/1682-0363-2023-1-65-72.

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Аim. To study the possibility of using a radiopharmaceutical based on aluminum oxide labeled with 99mТс ([99mТс]-Al2O3) for the diagnosis of sentinel lymph nodes (SLN) in tumors of the larynx and laryngopharynx in comparison with a phytate colloid ([99mTc]-phytate colloid).Materials and methods. The study included patients with cancer of the larynx and laryngopharynx (T2–4N0M0) (n = 54). In the prospective group (n = 30), [99mТс]-Al2O3 was used as a radiopharmaceutical, in the retrospective group (n = 24), [99mТс]-phytate colloid was used. All radiopharmaceuticals were introduced endoscopicall

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K., R. Satav, P. Shangrapawar T., and Ashok Bhosale Dr. "Illustrative Review on Radiopharmaceuticals." International Journal of Trend in Scientific Research and Development 4, no. 1 (2019): 905–11. https://doi.org/10.5281/zenodo.3609787.

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Radiopharmaceutical is a key component involved in the field of nuclear medicine. It serves various purposes diagnostically and also serves with different diagnostic applications. Radioactive agents are employed in nuclear field for demonstration of high and exact localized radioactive effect in a particular target tissue. In recent years various amount of radionuclides and radiopharmaceuticals are utilized for treating cancer and other complex disease like neuroendocrine disorder. This review focuses on the manufacturing, quality control tests and diagnostic applications of radiopharmaceutica

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Miranda, Ana Cláudia Camargo, Leonardo Lima Fuscaldi, Jorge Mejia, et al. "Radiosynthesis Standardization and Preclinical Assessment of the [68Ga]Ga-DOTA-Ubiquicidin29-41: A Translational Study Targeting Differential Diagnosis of Infectious Processes." Pharmaceuticals 17, no. 1 (2023): 48. http://dx.doi.org/10.3390/ph17010048.

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Human bacterial infections significantly contribute to the increase in healthcare-related burdens. This scenario drives the study of novel techniques for the early and precise diagnosis of infectious processes. Some alternatives include Nuclear Medicine- and Molecular Imaging-based strategies. However, radiopharmaceuticals that are available for routine assessments are not specific to differentiating infectious from aseptic inflammatory processes. In this context, [68Ga]Ga-DOTA-Ubiquicidin29-41 was synthesized using an automated module and radiochemical; in vivo and in vitro studies were perfo

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Chang, Ming-Cheng, Chun-Tang Chen, Ping-Fang Chiang, et al. "Development of INER-PP-F11N as the Peptide-Radionuclide Conjugate Drug Against CCK2 Receptor-Overexpressing Tumors." International Journal of Molecular Sciences 26, no. 14 (2025): 6565. https://doi.org/10.3390/ijms26146565.

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This work aimed to evaluate two albumin affinity structure-containing peptide-radionuclide conjugate drugs, INER-PP-F11N-1 and INER-PP-F11N-2, for the diagnosis/treatment of cholecystokinin receptor subtype 2 (CCK2R)-overexpressing cancers. We developed In-111- and Lu-177-labeled INER-PP-F11N radiopharmaceuticals and compared them with the current PP-F11N to investigate metabolic stability, biodistribution, SPECT/CT imaging, and therapeutic responses in CCK2R-expressing tumor xenograft mice. The metabolic stability of [111In]In/[177Lu]Lu-INER-PP-F11N remained above 90% for up to 144 h after la

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Vasquez, Marcial V., Héctor R. Vega, Santos L. Acuña, et al. "RADIOPHARMACEUTICAL RENAL DOSIMETRY USING SNYDER / CRISTY-ECKERMAN / SEGARS ANTHROPOMORPHIC REPRESENTATIONS." MOMENTO, no. 68 (January 2, 2024): 1–10. http://dx.doi.org/10.15446/mo.n68.102552.

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Absorbed doses to the kidneys of adult patients are estimated using the Medical Internal Radiation Dosimetry (MIRD) methodology and the anthropomorphic representations of Snyder, Cristy-Eckerman, and Segars. The radiopharmaceuticals 99mTc(DTPA), 99mTc(DMSA) and 99mTc(MAG3) are used to perform renal function studies in adults. The dose results found for these radiopharmaceuticals and their representations will allow the exploring of their dosimetric impact on each other. The relative difference in total renal dose by using the Snyder/Segars and Cristy-Eckerman/Segars anthropomorphic-representat

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Bildanov, Radiy G., Rafik G. Bildanov, and S. N. Larin. "ASSESSMENT OF ECONOMIC LOSSES AT ADVERSE SCENARIOS FOR PERFORMANCE OF THE TECHNOLOGICAL PROCESS OF PRODUCTION OF RADIOPHARMACEUTICAL DRUGS." Izvestiya of Samara Scientific Center of the Russian Academy of Sciences 23, no. 6 (2021): 72–77. http://dx.doi.org/10.37313/1990-5378-2021-23-6-72-77.

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The article discusses the production of radiopharmaceutical drugs, which is regulated by a significant number of rules and regulations, which is due to high requirements for the quality of drugs, the safety of their production and use in medical organizations. This determines the specifics and complexity of the process and dictates special requirements for the production management system and drug quality management. The aim of the work is to model the production process of radiopharmaceutical drugs and create a system for ensuring their quality in a given technological process. The work uses

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Carmo, Vildete Aparecida Sousa, Mônica Cristina de Oliveira, Luciene das Graças Mota, Luís Paulo Freire, Raphael Ligório Benedito Ferreira, and Valbert Nascimento Cardoso. "Technetium-99m-labeled stealth pH-sensitive liposomes: a new strategy to identify infection in experimental model." Brazilian Archives of Biology and Technology 50, spe (2007): 199–207. http://dx.doi.org/10.1590/s1516-89132007000600025.

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The diagnosis of inflammatory and infectious processes is an important goal in medicine. The use of radiopharmaceuticals for identification of inflammation and infection foci has received considerable attention. The aim of this work was to evaluate the uptake and the imaging potential of stealth pH-sensitive liposomes radiolabelled with 99mTechnetium (99mTc) to identify infection sites in mice. The liposomes containing glutathione were labeled with 99mTc-Hexamethylpropyleneamine oxime (HMPAO) complex. The 99mTc-labeled stealth pH-sensitive liposomes (99mTc-SpHL) were injected in mice bearing i

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Moreira, Mayra Lorena, Priscylla da Costa Medeiros, Sergio Augusto Lopes de Souza, Bianca Gutfilen, and Paulo Henrique Rosado-de-Castro. "In VivoTracking of Cell Therapies for Cardiac Diseases with Nuclear Medicine." Stem Cells International 2016 (2016): 1–15. http://dx.doi.org/10.1155/2016/3140120.

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Even though heart diseases are amongst the main causes of mortality and morbidity in the world, existing treatments are limited in restoring cardiac lesions. Cell transplantations, originally developed for the treatment of hematologic ailments, are presently being explored in preclinical and clinical trials for cardiac diseases. Nonetheless, little is known about the possible efficacy and mechanisms for these therapies and they are the center of continuous investigation. In this scenario, noninvasive imaging techniques lead to greater comprehension of cell therapies. Radiopharmaceutical cell l

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Liang, Steven H., and Neil Vasdev. "Total Radiosynthesis: Thinking Outside ‘the Box'." Australian Journal of Chemistry 68, no. 9 (2015): 1319. http://dx.doi.org/10.1071/ch15406.

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The logic of total synthesis transformed a stagnant state of chemistry when there was a paucity of methods and reagents to synthesize pharmaceuticals. Molecular imaging by positron emission tomography (PET) is now experiencing a renaissance in the way radiopharmaceuticals are synthesized; however, a paradigm shift is desperately needed in the radiotracer discovery pipeline to accelerate drug development. As with most drugs, most radiotracers also fail, therefore expeditious evaluation of tracers in preclinical models before optimization or derivatization of the lead molecules is necessary. Fur

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Vahidfar, Nasim, Saeed Farzanehfar, Mehrshad Abbasi, et al. "Diagnostic Value of Radiolabelled Somatostatin Analogues for Neuroendocrine Tumour Diagnosis: The Benefits and Drawbacks of [64Cu]Cu-DOTA-TOC." Cancers 14, no. 8 (2022): 1914. http://dx.doi.org/10.3390/cancers14081914.

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Neuroendocrine tumours (NETs) arise from secondary epithelial cell lines in the gastrointestinal or respiratory system organs. The rate of development of these tumours varies from an indolent to an aggressive course, typically being initially asymptomatic. The identification of these tumours is difficult, particularly because the primary tumour is often small and undetectable by conventional anatomical imaging. Consequently, diagnosis of NETs is complicated and has been a significant challenge until recently. In the last 30 years, the advent of novel nuclear medicine diagnostic procedures has

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Stanzhevskii, A. A., D. N. Maistrenko, D. A. Vazhenina, et al. "Methods of dosimetry-based treatment planning in radiopharmaceutical therapy. Part 2: Planning levels." Diagnostic radiology and radiotherapy 13, no. 4 (2023): 16–26. http://dx.doi.org/10.22328/2079-5343-2022-13-4-16-26.

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At the present time three most common approaches are used for the planning of the radionuclide therapy: administration of the fixed activity of radionuclide in radiopharmaceutical, or administration of activity normalized per unit of body mass or body surface. That may lead to significant deviations between the prescribed and real absorbed doses in healthy organs and tissues. These deviations are associated with differences in biodistribution and pharmacokinetics of radiopharmaceutical between models and real patients. That does not allow individual planning of the treatment course for each pa

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Theodoropoulos, Athanasios S., Ioannis Gkiozos, Georgios Kontopyrgias, et al. "Modern radiopharmaceuticals for lung cancer imaging with positron emission tomography/computed tomography scan: A systematic review." SAGE Open Medicine 8 (January 2020): 205031212096159. http://dx.doi.org/10.1177/2050312120961594.

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Introduction: In this study, we evaluated the use and the contribution of radiopharmaceuticals to the field of lung neoplasms imaging using positron emission tomography/computed tomography. Methods: We conducted review of the current literature at PubMed/MEDLINE until February 2020. The search language was English. Results: The most widely used radiopharmaceuticals are the following: Experimental/pre-clinical approaches: (18)F-Misonidazole (18F-MISO) under clinical development, D(18)F-Fluoro-Methyl-Tyrosine (18F-FMT), 18F-FAMT (L-[3-18F] (18)F-Fluorothymidine (18F-FLT)), (18)F-Fluoro-Azomycin-

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Mostafa, Ahmed M. A., Hesham M. H. Zakaly, Shams A. M. Issa, Mohamed A. M. Uosif, Ziyad A. Alrowaili, and Michael V. Zhukovsky. "Exploring the Potential of Zirconium-89 in Diagnostic Radiopharmaceutical Applications: An Analytical Investigation." Biomedicines 11, no. 4 (2023): 1173. http://dx.doi.org/10.3390/biomedicines11041173.

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This study highlights the use of 89Zr-oxalate in diagnostic applications with the help of WinAct and IDAC2.1 software. It presents the biodistribution of the drug in various organs and tissues, including bone, blood, muscle, liver, lung, spleen, kidneys, inflammations, and tumors, and analyzes the maximum amount of nuclear transformation per Bq intake for each organ. The retention time of the maximum nuclear transformation and the absorbed doses of the drug in various organs and tissues are also examined. Data from clinical and laboratory studies on radiopharmaceuticals are used to estimate th

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Jeong, Jae Min. "Radiopharmaceutical Chemistry." Journal of Nuclear Medicine 60, no. 12 (2019): 1833. http://dx.doi.org/10.2967/jnumed.119.237479.

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Sgouros, George. "Radiopharmaceutical Therapy." Health Physics 116, no. 2 (2019): 175–78. http://dx.doi.org/10.1097/hp.0000000000001000.

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Eckelman, William C., Michael R. Kilbourn, and Chester A. Mathis. "Radiopharmaceutical space." Nuclear Medicine and Biology 33, no. 7 (2006): 829. http://dx.doi.org/10.1016/j.nucmedbio.2006.07.005.

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WILLIAMS, E. D., and L. K. HARDINC. "Radiopharmaceutical maladministration." Nuclear Medicine Communications 16, no. 9 (1995): 721–23. http://dx.doi.org/10.1097/00006231-199509000-00001.

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