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Journal articles on the topic 'RADIORESISTANCES'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Nurhidayat, Ade Apon, Afiati Afiati, Hermin Aminah Usman, and Bethy Suryawathy Hernowo. "The Role of Cyclin D1 and VEGF in Radiotherapy Response of Advance Stage Undifferentiated Nasopharyngeal Carcinoma." Folia Medica Indonesiana 56, no. 4 (2020): 248. http://dx.doi.org/10.20473/fmi.v56i4.23405.

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Nasopharyngeal carcinoma has a high incidence and mortality rate in Southeast Asia and Indonesia. Radioresistance is a major obstacle to successful treatment of nasopharyngeal carcinoma. DNA repair in the cell cycle and angiogenesis factors affects the response of tumor cells to radiotherapy. Cyclin D1 that functions in the cell cycle process and VEGF as an angiogenesis factor are considered to play a role in the occurrence of radioresistance. The objective of this study is to find the association between immunoexpression of Cyclin D1 and VEGF with radiotherapy response in undifferentiated nas

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Nurhidayat, Ade Apon, Afiati Afiati, Hermin Aminah Usman, and Bethy Suryawathy Hernowo. "The Role of Cyclin D1 and VEGF in Radiotherapy Response of Advance Stage Undifferentiated Nasopharyngeal Carcinoma." Folia Medica Indonesiana 56, no. 4 (2021): 248. http://dx.doi.org/10.20473/fmi.v56i4.24554.

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Nasopharyngeal carcinoma has a high incidence and mortality rate in Southeast Asia and Indonesia. Radioresistance is a major obstacle to successful treatment of nasopharyngeal carcinoma. DNA repair in the cell cycle and angiogenesis factors affects the response of tumor cells to radiotherapy. Cyclin D1 that functions in the cell cycle process and VEGF as an angiogenesis factor are considered to play a role in the occurrence of radioresistance. The objective of this study is to find the association between immunoexpression of Cyclin D1 and VEGF with radiotherapy response in undifferentiated nas

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3

Banerjee, Swapnamay. "Study of Radioresistance and Bioremediation using Radio-Resistant Bacteria." International Journal of Science and Research (IJSR) 12, no. 7 (2023): 511–15. http://dx.doi.org/10.21275/sr23706211848.

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4

Lee, Jeeyong, Da Yeon Kim, Younjoo Kim, Ui Sup Shin, Kwang Seok Kim, and Eun Ju Kim. "IGFL2-AS1, A Long Non-Coding RNA, Is Associated with Radioresistance in Colorectal Cancer." International Journal of Molecular Sciences 24, no. 2 (2023): 978. http://dx.doi.org/10.3390/ijms24020978.

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Precise prediction of radioresistance is an important factor in the treatment of colorectal cancer (CRC). To discover genes that regulate the radioresistance of CRCs, we analyzed an RNA sequencing dataset of patient-originated samples. Among various candidates, IGFL2-AS1, a long non-coding RNA (lncRNA), exhibited an expression pattern that was well correlated with radioresistance. IGFL2-AS1 is known to be highly expressed in various cancers and functions as a competing endogenous RNA. To further investigate the role of IGFL2-AS1 in radioresistance, which has not yet been studied, we assessed t

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Ushakov, I. B., and A. N. Kordenko. "On the Relationship of Natural and Modified Radioresistance with Mast Cell Reactivity." Радиационная биология. Радиоэкология 63, no. 4 (2023): 387–93. http://dx.doi.org/10.31857/s0869803123040100.

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This study was caused by accumulation of the data concerning: 1) relationship between the general reactivity of the body and radioresistance; 2) essential role of mast cells in the formation of radiobiological effects; 3) significant individual features of body radioresistance. Purpose of the study was to identify the relationship of radioresistance indicators with the state of body reactivity, manifested by constitutionally determined features of connective tissue mast cells. Natural radioresistance and modifying effect of hypoxia, hyperoxia and indralin radioprotector were considered. The st

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Han, Myung Woul. "The Mechanisms and Overcoming Strategies of the Radioresistance in Head and Neck Cancer." Korean Journal of Otorhinolaryngology-Head and Neck Surgery 66, no. 5 (2023): 295–301. http://dx.doi.org/10.3342/kjorl-hns.2022.01102.

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Radiotherapy plays an important role in the treatment of most of solid tumors including head and neck squamous cell carcinoma (HNSCC). Radioresistance can lead to locoregional recurrence and distant metastases. Despite significant progress in research of radioresistance, its prediction and overcoming strategies remain challenging. This review describes the potential biomarkers correlated to the radioresistance and complex signal pathway in mechanism of radioresistance focusing on the PI3K and EphA3 pathway.

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Wu, Shunlong, Zhaodong Li, Haiyu Li, and Kui Liao. "Dihydroartemisinin Reduces Irradiation-Induced Mitophagy and Radioresistance in Lung Cancer A549 Cells via CIRBP Inhibition." Life 12, no. 8 (2022): 1129. http://dx.doi.org/10.3390/life12081129.

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Radiotherapy is a major therapeutic strategy for lung cancer, and radiation resistance (radioresistance) is an important cause of residual and recurring cancer after treatment. However, the mechanism of radioresistance remains unclear. Mitochondrial autophagy (mitophagy), an important selective autophagy, plays an important role in maintaining cell homeostasis and affects the response to therapy. Recent studies have shown that dihydroartemisinin (DHA), a derivative of artemisinin, can increase the sensitivity to treatment in multiple types of cancer, including lung cancer. The purpose of this

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Li, Zhifeng, Fujin Wang, Yinxing Zhu, Ting Guo, and Mei Lin. "Long Noncoding RNAs Regulate the Radioresistance of Breast Cancer." Analytical Cellular Pathology 2021 (September 20, 2021): 1–11. http://dx.doi.org/10.1155/2021/9005073.

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Breast cancer (BRCA) has severely threatened women’s health worldwide. Radiotherapy is a treatment for BRCA, which applies high doses of ionizing radiation to induce cancer cell death and reduce disease recurrence. Radioresistance is one of the most important elements that affect the therapeutic efficacy of radiotherapy. Long noncoding RNAs (lncRNAs) are suggested to dominate crucial roles in regulating the biological behavior of BRCA. Currently, some studies indicate that overexpression or inhibition of lncRNAs can greatly alter the radioresistance of BRCA. In this review, we summarized the k

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Krause, M., A. Dubrovska, and M. Baumann. "Overcoming Cancer Radioresistance Factors of radioresistance in prostate cancer." Radiotherapy and Oncology 118 (February 2016): S63. http://dx.doi.org/10.1016/s0167-8140(16)30128-1.

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10

Chen, Qiao, Shugen Qu, Zhenzhen Liang, et al. "Cathepsin H Knockdown Reverses Radioresistance of Hepatocellular Carcinoma via Metabolic Switch Followed by Apoptosis." International Journal of Molecular Sciences 24, no. 6 (2023): 5257. http://dx.doi.org/10.3390/ijms24065257.

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Despite the wide application of radiotherapy in HCC, radiotherapy efficacy is sometimes limited due to radioresistance. Although radioresistance is reported with high glycolysis, the underlying mechanism between radioresistance and cancer metabolism, as well as the role of cathepsin H (CTSH) within it, remain unclear. In this study, tumor-bearing models and HCC cell lines were used to observe the effect of CTSH on radioresistance. Proteome mass spectrometry, followed by enrichment analysis, were used to investigate the cascades and targets regulated by CTSH. Technologies such as immunofluoresc

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Ali, Md Yousuf, Claudia R. Oliva, Abu Shadat M. Noman, et al. "Radioresistance in Glioblastoma and the Development of Radiosensitizers." Cancers 12, no. 9 (2020): 2511. http://dx.doi.org/10.3390/cancers12092511.

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Ionizing radiation is a common and effective therapeutic option for the treatment of glioblastoma (GBM). Unfortunately, some GBMs are relatively radioresistant and patients have worse outcomes after radiation treatment. The mechanisms underlying intrinsic radioresistance in GBM has been rigorously investigated over the past several years, but the complex interaction of the cellular molecules and signaling pathways involved in radioresistance remains incompletely defined. A clinically effective radiosensitizer that overcomes radioresistance has yet to be identified. In this review, we discuss t

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Zhao, Yuanyuan, Leilei Tao, Jun Yi, Haizhu Song, and Longbang Chen. "The Role of Canonical Wnt Signaling in Regulating Radioresistance." Cellular Physiology and Biochemistry 48, no. 2 (2018): 419–32. http://dx.doi.org/10.1159/000491774.

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Radioresistance is a major obstacle in radiotherapy for cancer, and strategies are needed to overcome this problem. Currently, radiotherapy combined with targeted therapy such as inhibitors of phosphoinosotide 3-kinase/Akt and epidermal growth factor receptor signaling have become the focus of studies on radiosensitization. Apart from these two signaling pathways, which promote radioresistance, deregulation of Wnt signaling is also associated with the radioresistance of multiple cancers. Wnts, as important messengers in the tumor microenvironment, are involved in cancer progression mainly via

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Woo, Yunseo, Hyo-Ji Lee, Young Mee Jung, and Yu-Jin Jung. "mTOR-Mediated Antioxidant Activation in Solid Tumor Radioresistance." Journal of Oncology 2019 (December 20, 2019): 1–11. http://dx.doi.org/10.1155/2019/5956867.

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Radiotherapy is widely used for the treatment of cancer patients, but tumor radioresistance presents serious therapy challenges. Tumor radioresistance is closely related to high levels of mTOR signaling in tumor tissues. Therefore, targeting the mTOR pathway might be a strategy to promote solid tumor sensitivity to ionizing radiation. Radioresistance is associated with enhanced antioxidant mechanisms in cancer cells. Therefore, examination of the relationship between mTOR signaling and antioxidant mechanism-linked radioresistance is required for effective radiotherapy. In particular, the effec

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Kamble, Dinisha, Megharani Mahajan, Rohini Dhat, and Sandhya Sitasawad. "Keap1-Nrf2 Pathway Regulates ALDH and Contributes to Radioresistance in Breast Cancer Stem Cells." Cells 10, no. 1 (2021): 83. http://dx.doi.org/10.3390/cells10010083.

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Tumor recurrence after radiotherapy due to the presence of breast cancer stem cells (BCSCs) is a clinical challenge, and the mechanism remains unclear. Low levels of ROS and enhanced antioxidant defenses are shown to contribute to increasing radioresistance. However, the role of Nrf2-Keap1-Bach1 signaling in the radioresistance of BCSCs remains elusive. Fractionated radiation increased the percentage of the ALDH-expressing subpopulation and their sphere formation ability, promoted mesenchymal-to-epithelial transition and enhanced radioresistance in BCSCs. Radiation activated Nrf2 via Keap1 sil

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Chen, Ting-Wen, Kai-Ping Chang, Chun-Chia Cheng, et al. "Characterization of Recurrent Relevant Genes Reveals a Novel Role of RPL36A in Radioresistant Oral Squamous Cell Carcinoma." Cancers 13, no. 22 (2021): 5623. http://dx.doi.org/10.3390/cancers13225623.

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Radioresistance is one of the major factors that contributes to radiotherapy failure in oral cavity squamous cell carcinoma (OSCC). By comparing the prognostic values of 20,502 genes expressed in patients in The Cancer Genome Atlas (TCGA)-OSCC cohort with (n = 162) and without radiotherapy (n = 118), herein identified 297 genes positively correlated with poor disease-free survival in OSCC patients with radiotherapy as the potential radioresistance-associated genes. Among the potential radioresistance-associated genes, 36 genes were upregulated in cancerous tissues relative to normal tissues. T

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Lang, Liwei, Fanghui Chen, Yamin Li, et al. "Adaptive c-Met-PLXDC2 Signaling Axis Mediates Cancer Stem Cell Plasticity to Confer Radioresistance-associated Aggressiveness in Head and Neck Cancer." Cancer Research Communications 3, no. 4 (2023): 659–71. http://dx.doi.org/10.1158/2767-9764.crc-22-0289.

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Radiotherapy plays an essential role in the treatment of head and neck squamous cell carcinoma (HNSCC), yet radioresistance remains a major barrier to therapeutic efficacy. A better understanding of the predominant pathways determining radiotherapy response could help develop mechanism-informed therapies to improve cancer management. Here we report that radioresistant HNSCC cells exhibit increased tumor aggressiveness. Using unbiased proteome profiler antibody arrays, we identify that upregulation of c-Met phosphorylation is one of the critical mechanisms for radioresistance in HNSCC cells. We

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King, Liam, Nijole Bernaitis, David Christie, et al. "Drivers of Radioresistance in Prostate Cancer." Journal of Clinical Medicine 11, no. 19 (2022): 5637. http://dx.doi.org/10.3390/jcm11195637.

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Prostate cancer (PCa) is the second most commonly diagnosed cancer worldwide. Radiotherapy remains one of the first-line treatments in localised disease and may be used as monotherapy or in combination with other treatments such as androgen deprivation therapy or radical prostatectomy. Despite advancements in delivery methods and techniques, radiotherapy has been unable to totally overcome radioresistance resulting in treatment failure or recurrence of previously treated PCa. Various factors have been linked to the development of tumour radioresistance including abnormal tumour vasculature, ox

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Hashimoto, Takuma, Kazuki Tsubota, Khaled Hatabi, and Yoshio Hosoi. "FDX1 Regulates the Phosphorylation of ATM, DNA-PKcs Akt, and EGFR and Affects Radioresistance Under Severe Hypoxia in the Glioblastoma Cell Line T98G." International Journal of Molecular Sciences 26, no. 7 (2025): 3378. https://doi.org/10.3390/ijms26073378.

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Hypoxic cells exhibit radioresistance, which is associated with poor prognosis in cancer patients. Understanding the molecular mechanisms underlying radioresistance in hypoxic tumor cells is crucial for improving radiotherapy efficacy. In this study, we examined the role of FDX1 in regulating cellular responses to severe hypoxia in glioblastoma cell lines T98G and A172. We found that FDX1 expression was upregulated under severe hypoxia, and its knockdown reduced the hypoxia-induced activation of key radioresistance factors and cellular survival mechanisms, including ATM, DNA-PKcs, Akt, and EGF

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Chen, Fanghui, Liwei Lang, Chloe Shay, Georgia Chen, Nabil Saba, and Yong Teng. "Abstract 5793: Met confers radioresistance-associated aggressiveness through enhancing PLXDC2-mediated cancer stem cell plasticity." Cancer Research 83, no. 7_Supplement (2023): 5793. http://dx.doi.org/10.1158/1538-7445.am2023-5793.

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Abstract The development of radioresistance in head and neck squamous cell carcinoma (HNSCC) remains a significant problem in cancer treatment, contributing to the lack of improvement in survival trends in the past decades. One of the clinical challenges is that radioresistance often promotes tumor aggressiveness. However, the underlying mechanisms and molecular determinants are largely unknown. We report here that radioresistance-associated HNSCC aggressiveness is effectively exacerbated by c-Met but can be suppressed by its genetic knockdown and pharmacological inactivation. Through unbiased

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Xiang, Junyi, Bodong Lv, Shufeng Fan, Zhitian Zhang, and Hui Yang. "Deltex E3 Ubiquitin Ligase 3L confers radioresistance in prostate cancer via Akt pathway." Tropical Journal of Pharmaceutical Research 19, no. 7 (2020): 1397–402. http://dx.doi.org/10.4314/tjpr.v19i7.9.

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Purpose: To determine the effect of Deltex E3 Ubiquitin Ligase 3L (DTX3L) on the radioresistance of prostate cancer (PCa).Methods: A PCa cell model of radioresistance was established via exposure of cancer cell lines to fractionated radiation. The MTT {(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide)} assay and western blotting were performed to evaluate the impact of DTX3L on cell survival and DNA damage repair. The molecular mechanism of action was evaluated by western blotting.Results: DTX3L was elevated in PCa cell lines compared with normal primary prostate epithelial cells

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Vastrade, Martin, Valérie Cornet, Anne-Catherine Heuskin, and Boris Hespeels. "Ant-icipating the fallout: a study on the radioresistance of the black garden ant Lasius niger." Belgian Journal of Zoology 154 (October 3, 2024): 161–78. http://dx.doi.org/10.26496/bjz.2024.194.

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The radioresistance of ants has been a subject of curiosity and fascination, with speculation that they could thrive in radiation-contaminated environments, such as those resulting from nuclear fallout. This study investigates the radioresistance of the black garden ant Lasius niger, a widespread species inhabiting many geolocations around the world. Newly mated queens were exposed to varying doses of X-ray radiation (0–250 Gy) prior to colony initiation, and survival, fertility, and offspring development were monitored over a 77-day period. Results showed high survival rates across a broad ra

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Zaffaroni, Mattia, Maria Giulia Vincini, Giulia Corrao, et al. "Unraveling Mitochondrial Determinants of Tumor Response to Radiation Therapy." International Journal of Molecular Sciences 23, no. 19 (2022): 11343. http://dx.doi.org/10.3390/ijms231911343.

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Radiotherapy represents a highly targeted and efficient treatment choice in many cancer types, both with curative and palliative intents. Nevertheless, radioresistance, consisting in the adaptive response of the tumor to radiation-induced damage, represents a major clinical problem. A growing body of the literature suggests that mechanisms related to mitochondrial changes and metabolic remodeling might play a major role in radioresistance development. In this work, the main contributors to the acquired cellular radioresistance and their relation with mitochondrial changes in terms of reactive

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Tomita, Kazuo, Taisuke Nagasawa, Yoshikazu Kuwahara, et al. "MiR-7-5p Is Involved in Ferroptosis Signaling and Radioresistance Thru the Generation of ROS in Radioresistant HeLa and SAS Cell Lines." International Journal of Molecular Sciences 22, no. 15 (2021): 8300. http://dx.doi.org/10.3390/ijms22158300.

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In cancer therapy, radioresistance or chemoresistance cells are major problems. We established clinically relevant radioresistant (CRR) cells that can survive over 30 days after 2 Gy/day X-ray exposures. These cells also show resistance to anticancer agents and hydrogen peroxide (H2O2). We have previously demonstrated that all the CRR cells examined had up-regulated miR-7-5p and after miR-7-5p knockdown, they lost radioresistance. However, the mechanism of losing radioresistance remains to be elucidated. Therefore, we investigated the role of miR-7-5p in radioresistance by knockdown of miR-7-5

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Pranatharthi, Annapurna, Cecil Ross, and Sweta Srivastava. "Cancer Stem Cells and Radioresistance: Rho/ROCK Pathway Plea Attention." Stem Cells International 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/5785786.

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Radiation is the most potent mode of cancer therapy; however, resistance to radiation therapy results in tumor relapse and subsequent fatality. The cancer stem cell (CSC), which has better DNA repair capability, has been shown to contribute to tumor resistance and is an important target for treatment. Signaling molecules such as Notch, Wnt, and DNA repair pathways regulate molecular mechanisms in CSCs; however, none of them have been translated into therapeutic targets. The RhoGTPases and their effector ROCK-signaling pathway, though important for tumor progression, have not been well studied

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Sato, Kota, Hironori Yoshino, Yoshiaki Sato, Manabu Nakano та Eichi Tsuruga. "ΔNp63 Regulates Radioresistance in Human Head and Neck Squamous Carcinoma Cells". Current Issues in Molecular Biology 45, № 8 (2023): 6262–71. http://dx.doi.org/10.3390/cimb45080394.

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Radiation therapy is commonly used to treat head and neck squamous cell carcinoma (HNSCC); however, recurrence results from the development of radioresistant cancer cells. Therefore, it is necessary to identify the underlying mechanisms of radioresistance in HNSCC. Previously, we showed that the inhibition of karyopherin-β1 (KPNB1), a factor in the nuclear transport system, enhances radiation-induced cytotoxicity, specifically in HNSCC cells, and decreases the localization of SCC-specific transcription factor ΔNp63. This suggests that ΔNp63 may be a KPNB1-carrying nucleoprotein that regulates

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Schaue, Dörthe, Ewa D. Micewicz, Josephine A. Ratikan, et al. "NRF2 Mediates Cellular Resistance to Transformation, Radiation, and Inflammation in Mice." Antioxidants 11, no. 9 (2022): 1649. http://dx.doi.org/10.3390/antiox11091649.

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Nuclear factor erythroid 2-related factor 2 (NRF2) is recognized as a master transcription factor that regulates expression of numerous detoxifying and antioxidant cytoprotective genes. In fact, models of NRF2 deficiency indicate roles not only in redox regulation, but also in metabolism, inflammatory/autoimmune disease, cancer, and radioresistancy. Since ionizing radiation (IR) generates reactive oxygen species (ROS), it is not surprising it activates NRF2 pathways. However, unexpectedly, activation is often delayed for many days after the initial ROS burst. Here, we demonstrate that, as assa

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Kim, Byeongsoo, Haksoo Lee, Dahye Kim, et al. "TMET-08. RADIATION-INDUCED SLC25A22 CONTRIBUTES TO GLIOBLASTOMA RADIORESISTANCE ACQUISITION THROUGH REMODELING GLUTAMATE METABOLISM." Neuro-Oncology 26, Supplement_8 (2024): viii289. http://dx.doi.org/10.1093/neuonc/noae165.1146.

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Abstract Glioblastoma Multiforme (GBM), a malignant primary brain tumor, is treated by surgical resection followed by chemo- and radiotherapy. Nevertheless, most GBM patients show dismal prognosis due to the radioresistance acquisition of GBM cells via metabolic rewiring. Therefore, it is urgently required to discover how metabolic rewiring attributes to GBM radioresistance, and its targeting strategies. To identify GBM radioresistance driver genes, we previously established radioresistance GBM cells (RGCs) via repetitive in vivo selection, followed by mRNA sequencing, and selected candidate g

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Chorna, Inna. "MOLECULAR MECHANISMS UNDERLYING CANCER CELL RADIORESISTANCE." Scientific Journal of Polonia University 48, no. 5 (2022): 142–51. http://dx.doi.org/10.23856/4818.

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Radioresistance of the tumor cells remains a significant obstacle for the radiotherapy treatment of cancer. Radioresistance involves multiple genes, factors, and mechanisms that adapt cancer cells or tissues to radiotherapy-induced changes and develop resistance to ionizing radiation. The major studies of the effect of radiation on cells reported include the following areas: 1) the study of DNA damages and their repair; 2) mutations in tumor suppressor genes and radiation-induced oncogene expression; 3) the role of growth factors and cytokines; 4) violation of the cell cycle; 5) elucidation of

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Liu, Hongxia, Qianping Chen, Wang Zheng, et al. "LncRNA CASC19 Enhances the Radioresistance of Nasopharyngeal Carcinoma by Regulating the miR-340-3p/FKBP5 Axis." International Journal of Molecular Sciences 24, no. 3 (2023): 3047. http://dx.doi.org/10.3390/ijms24033047.

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Radioresistance remains a serious obstacle encountered in the radiotherapy of nasopharyngeal carcinoma (NPC). Both mRNAs and non-coding RNAs (ncRNAs), including long ncRNA (lncRNA) and microRNA (miRNA), play essential roles in radiosensitivity. However, the comprehensive expression profiles and competing endogenous RNA (ceRNA) regulatory networks among lncRNAs, miRNAs, and mRNAs in NPC radioresistance are still bewildering. In this study, we performed an RNA-sequencing (RNA-seq) assay in the radioresistant NPC cells CNE2R and its parental cells CNE2 to identify the differentially expressed lnc

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Omelchuk, E. P., D. S. Kutilin, S. N. Dimitriadi, M. A. Gusarev, and N. N. Timoshkina. "Molecular genetic aspects of prostate cancer radioresistance." Bulletin of Siberian Medicine 20, no. 3 (2021): 182–92. http://dx.doi.org/10.20538/1682-0363-2021-3-182-192.

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Radioresistance of prostate cancer is a complex therapeutic problem. Biochemical recurrence after radiation therapy occurs in 22–69% of patients with prostate cancer. Nearly half of these patients progress to a clinical relapse within 15 years, and a third progress to castration-resistant prostate cancer. This review analyzes literature data on radioresistance mechanisms in prostate cancer cells. We searched for literature published in eLibrary, PubMed, and Scopus databases by key words: prostate cancer, radioresistance, markers. In total, 568 foreign and 178 national articles published betwee

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Ma, Yanning, Dongheng Huang, Xingtong Li, et al. "GADD45B induced the enhancing of cell viability and proliferation in radiotherapy and increased the radioresistance of HONE1 cells." Open Chemistry 19, no. 1 (2021): 1224–34. http://dx.doi.org/10.1515/chem-2021-0105.

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Abstract This study aimed to investigate the key role and mechanism of GADD45B in the radiation resistance of nasopharyngeal carcinoma (NPC) cell lines. Radiotherapy-resistant HONE1 (HONE1-R) cells with stable genetic radioresistance were cultured under continuous radiation stimulation. CCK-8 and clone formation assays were used to verify the radioresistance of the cell line. Transcriptome sequencing was used to identify the most important differential signaling pathway in the cell line. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) and Western blot analysis were used

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Chen, Fanghui, Yang Fan, Chris Tang, Qin Richard, Zheng Wei, and Yong Teng. "Abstract 2813: Pyruvate kinase M2 confers radioresistance in head and neck cancer through reprograming the tumor-immune microenvironment via ECM1." Cancer Research 83, no. 7_Supplement (2023): 2813. http://dx.doi.org/10.1158/1538-7445.am2023-2813.

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Abstract Radiotherapy plays an essential role in cancer treatment, yet radioresistance remains a major barrier to therapeutic efficacy. A better understanding of the predominant pathways determining radiotherapy response could help develop mechanism-informed therapies to improve cancer management. PKM2, an enzyme that regulates the final rate-limiting step of glycolysis, has different functions in the occurrence, progression and metastasis of cancer. However, whether PKM2 plays a vital role in radioresistance is unclear, especially in head and neck squamous cell carcinoma (HNSCC). Here we repo

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Yang, Linlin, Changxian Shen, Adriana Estrada-Bernal, et al. "Oncogenic KRAS drives radioresistance through upregulation of NRF2-53BP1-mediated non-homologous end-joining repair." Nucleic Acids Research 49, no. 19 (2021): 11067–82. http://dx.doi.org/10.1093/nar/gkab871.

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Abstract KRAS-activating mutations are oncogenic drivers and are correlated with radioresistance of multiple cancers, including colorectal cancer, but the underlying precise molecular mechanisms remain elusive. Herein we model the radiosensitivity of isogenic HCT116 and SW48 colorectal cancer cell lines bearing wild-type or various mutant KRAS isoforms. We demonstrate that KRAS mutations indeed lead to radioresistance accompanied by reduced radiotherapy-induced mitotic catastrophe and an accelerated release from G2/M arrest. Moreover, KRAS mutations result in increased DNA damage response and

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Pustovalova, Margarita, Philipp Malakhov, Anastasia Guryanova, et al. "Transcriptome-Based Traits of Radioresistant Sublines of Non-Small Cell Lung Cancer Cells." International Journal of Molecular Sciences 24, no. 3 (2023): 3042. http://dx.doi.org/10.3390/ijms24033042.

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Radioresistance is a major obstacle for the successful therapy of many cancers, including non-small cell lung cancer (NSCLC). To elucidate the mechanism of radioresistance of NSCLC cells and to identify key molecules conferring radioresistance, the radioresistant subclones of p53 wild-type A549 and p53-deficient H1299 cell cultures were established. The transcriptional changes between parental and radioresistant NSCLC cells were investigated by RNA-seq. In total, expression levels of 36,596 genes were measured. Changes in the activation of intracellular molecular pathways of cells surviving ir

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Sheng, Yuhan, Baofang Zhang, Biyuan Xing, et al. "Cancer-Associated Fibroblasts Exposed to High-Dose Ionizing Radiation Promote M2 Polarization of Macrophages, Which Induce Radiosensitivity in Cervical Cancer." Cancers 15, no. 5 (2023): 1620. http://dx.doi.org/10.3390/cancers15051620.

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Radiotherapy, including brachytherapy, is a major therapeutic regimen for cervical cancer. Radioresistance is a decisive factor in radiation treatment failure. Tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs) in the tumor microenvironment are critical factors in the curative effects of cancer therapies. However, the interactions between TAMs and CAFs in the context of ionizing radiation are not fully understood. This study was undertaken to investigate whether M2 macrophages induce radioresistance in cervical cancer and to explore the TAMs’ phenotypic transformation

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Kelley, Kevin, Jonathan Knisely, Marc Symons, and Rosamaria Ruggieri. "Radioresistance of Brain Tumors." Cancers 8, no. 4 (2016): 42. http://dx.doi.org/10.3390/cancers8040042.

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Zinchenko, V. A. "Radioresistance of tumor cells." Biopolymers and Cell 14, no. 1 (1998): 12–18. http://dx.doi.org/10.7124/bc.0004b2.

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Morović, Sara. "Tumor Hypoxia and Radioresistance." Radiološki vjesnik 48, no. 2 (2024): 52–58. http://dx.doi.org/10.55378/rv.48.2.6.

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Tumor hypoxia is a prevalent feature of solid tumors, significantly contributing to increased tumor aggressiveness, metastatic potential, and resistance to conventional therapies such as radiotherapy. This review explores the complex relationship between tumor hypoxia and radioresistance, highlighting the molecular mechanisms involved and potential therapeutic strategies to enhance radiotherapy efficacy in hypoxic tumors. Key mechanisms include the role of hypoxia-inducible factors (HIFs), particularly HIF-1α, which regulates numerous genes involved in tumor survival, proliferation, and resist

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39

Weitzman, Jonathan B. "Radiodurans' rings and radioresistance." Genome Biology 4 (2003): spotlight—20030113–01. http://dx.doi.org/10.1186/gb-spotlight-20030113-01.

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Tang, Z., D. Lemke, P. Seidel, et al. "Glioma Invasion Confers Radioresistance." International Journal of Radiation Oncology*Biology*Physics 84, no. 3 (2012): S704. http://dx.doi.org/10.1016/j.ijrobp.2012.07.1883.

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Gao, Yining, Jiawen Gao, Fei Lin, et al. "CircRNAs in Tumor Radioresistance." Biomolecules 12, no. 11 (2022): 1586. http://dx.doi.org/10.3390/biom12111586.

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Circular RNAs (circRNAs) are endogenous, non-coding RNAs, which are derived from host genes that are present in several species and can be involved in the progression of various diseases. circRNAs’ leading role is to act as RNA sponges. In recent years, the other roles of circRNAs have been discovered, such as regulating transcription and translation, regulating host genes, and even being translated into proteins. As some tumor cells are no longer radiosensitive, tumor radioresistance has since become a challenge in treating tumors. In recent years, circRNAs are differentially expressed in tum

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42

Coucke, P. A., and N. E. A. Crompton. "Molecular basis of radioresistance." European Journal of Cancer 31, no. 5 (1995): 844–46. http://dx.doi.org/10.1016/0959-8049(95)00115-y.

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Kola, Prithwish, Prasanth Kumar Bhusetty Nagesh, Pritam Kumar Roy, et al. "Innovative nanotheranostics: Smart nanoparticles based approach to overcome breast cancer stem cells mediated chemo‐ and radioresistances." WIREs Nanomedicine and Nanobiotechnology, January 4, 2023. http://dx.doi.org/10.1002/wnan.1876.

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Chanya, Engsiridumrongkul, Chang Lei, and Saeed Shah Akbar. "Novel Therapy and Diagnosis of Cervical Cancer Radio Resistance for the Future Development." November 21, 2021. https://doi.org/10.5281/zenodo.5717200.

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Background and introduction: Cervical cancer (CC) is the world's fourth most common malignancy in women, it is predicted that there will be roughly 798 thousand new cases per year during the next 20 years. In the developing world, to overcome this malignancy the standard treatment for cervical cancer is radiotherapy, either alone or in conjunction with chemotherapy. During their treatment, about 80% of cervical cancer patients got radiation therapy. Radio resistance, on the other hand, reduced overall survival. Method: The method of this study is used to conduct online and a regular explor

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Qian, Duocheng, Quan Li, Yansong Zhu, and Dujian Li. "Comprehensive analysis of key proteins involved in radioresistance of prostate cancer by integrating protein-protein interaction networks." Current Bioinformatics 15 (June 5, 2020). http://dx.doi.org/10.2174/1574893615999200605143510.

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Background: Radioresistance remains a significant obstacle in the treatment of prostate cancer (PCa). The mechanisms underlying the radioresistance in PCa remained to be further investigated. Methods: GSE53902 dataset was used in this study to identify radioresistance-related mRNAs. Proteinprotein interaction (PPI) network was constructed based on STRING analysis. DAVID system was used to predict the potential roles of radioresistance-related mRNAs. Results: We screened and re-annotated GSE53902 dataset to identify radioresistance-related mRNAs. A total of 445 up-regulated and 1036 downregulat

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Zhou, Junying, Ningjing Lei, Wanjia Tian, et al. "Recent progress of the tumor microenvironmental metabolism in cervical cancer radioresistance." Frontiers in Oncology 12 (October 12, 2022). http://dx.doi.org/10.3389/fonc.2022.999643.

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Radiotherapy is widely used as an indispensable treatment option for cervical cancer patients. However, radioresistance always occurs and has become a big obstacle to treatment efficacy. The reason for radioresistance is mainly attributed to the high repair ability of tumor cells that overcome the DNA damage caused by radiotherapy, and the increased self-healing ability of cancer stem cells (CSCs). Accumulating findings have demonstrated that the tumor microenvironment (TME) is closely related to cervical cancer radioresistance in many aspects, especially in the metabolic processes. In this re

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Zhang, Qin, and Shuxiang Zhang. "miR-214 promotes radioresistance in human ovarian cancer cells by targeting PETN." Bioscience Reports 37, no. 4 (2017). http://dx.doi.org/10.1042/bsr20170327.

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Ovarian cancer is one of the leading causes of death among gynecological malignancies. Increasing evidence indicate that dysregulation of microRNAs (miRNAs) plays an important role in tumor radioresistance. The aim of the present study is to investigate whether microRNA-214 (miR-214) was involved in radioresistance of human ovarian cancer. Here, we showed that miR-214 was significantly up-regulated in ovarian cancer tissues and radioresistance ovarian cancer cell lines. Transfection of miR-214 agomir in radiosensitive ovarian cancer cell lines promoted them for resistance to ionizing radiation

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Wu, Wenhan, Shijian Zhang, and Jia He. "The Mechanism of Long Non-coding RNA in Cancer Radioresistance/Radiosensitivity: A Systematic Review." Frontiers in Pharmacology 13 (May 5, 2022). http://dx.doi.org/10.3389/fphar.2022.879704.

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Background and purpose: Radioresistance remains a significant challenge in tumor therapy. This systematic review aims to demonstrate the role of long non-coding RNA (lncRNA) in cancer radioresistance/radiosensitivity.Material and methods: The electronic databases Pubmed, Embase, and Google Scholar were searched from January 2000 to December 2021 to identify studies addressing the mechanisms of lncRNAs in tumor radioresistance/sensitivity, each of which required both in vivo and in vitro experiments.Results: Among the 87 studies identified, lncRNAs were implicated in tumor radioresistance/sensi

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Khan, Imran, Sadaf Mahfooz, Busra Karacam, et al. "Hypofractionated Radiation Therapy Suppresses Radioresistance in U87 Human Glioma Cells by Inhibiting Yap1 and Hsp90 Proteins." Current Radiopharmaceuticals 17 (April 29, 2024). http://dx.doi.org/10.2174/0118744710300495240409074900.

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Background:: Radiotherapy plays a vital role in the management of high-grade gliomas. However, the radio resistance of glioma cells limits the effect of radiation and drives recurrence inside the irradiated tumor volume leading to poor outcomes for patients. Methods:: High-grade glioma cell radioresistance significantly contributes to radiotherapy failure, highlighting the importance of identifying predictive biomarkers for radioresistance. An increasing body of evidence complies with the Yes Associated Protein 1 (Yap-1) and heat shock protein 90 (Hsp90) as biomarkers for radioresistance in gl

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Qiao, Lili, Yanfei Chen, Ning Liang, et al. "Targeting Epithelial-to-Mesenchymal Transition in Radioresistance: Crosslinked Mechanisms and Strategies." Frontiers in Oncology 12 (February 16, 2022). http://dx.doi.org/10.3389/fonc.2022.775238.

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Radiotherapy exerts a crucial role in curing cancer, however, its treatment efficiency is mostly limited due to the presence of radioresistance. Epithelial-to-mesenchymal transition (EMT) is a biological process that endows the cancer cells with invasive and metastatic properties, as well as radioresistance. Many potential mechanisms of EMT-related radioresistance being reported have broaden our cognition, and hint us the importance of an overall understanding of the relationship between EMT and radioresistance. This review focuses on the recent progresses involved in EMT-related mechanisms in

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