Academic literature on the topic 'Radiotherapy fractionation schemes'

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Journal articles on the topic "Radiotherapy fractionation schemes"

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Kuznetsov, Maxim, and Andrey Kolobov. "Optimization of Dose Fractionation for Radiotherapy of a Solid Tumor with Account of Oxygen Effect and Proliferative Heterogeneity." Mathematics 8, no. 8 (2020): 1204. http://dx.doi.org/10.3390/math8081204.

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A spatially-distributed continuous mathematical model of solid tumor growth and treatment by fractionated radiotherapy is presented. The model explicitly accounts for three time and space-dependent factors that influence the efficiency of radiotherapy fractionation schemes—tumor cell repopulation, reoxygenation and redistribution of proliferative states. A special algorithm is developed, aimed at finding the fractionation schemes that provide increased tumor cure probability under the constraints of maximum normal tissue damage and maximum fractional dose. The optimization procedure is perform
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Antunac, Katarina, and Lidija Beketić-Orešković. "Breast cancer radiotherapy - changes in fractionation schemes through decades." Libri Oncologici Croatian Journal of Oncology 51, no. 1 (2023): 20–24. http://dx.doi.org/10.20471/lo.2023.51.01.03.

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Traditionally, as a standard dose fractionation schedule, adjuvant radiotherapy for breast cancer has been performed using prescribed doses of 46–50 Gy divided into daily fractions of 1.8–2 Gy. Overall, radiotherapy treatment took 5 weeks. In the 1990s, schedules using higher daily doses (2.5–3 Gy), a smaller number of fractions (hypofractionation), and a reduced overall prescribed dose started in the context of clinical trials. First results revealed an equivalent cosmetic effect of hypofractionated protocols compared to standard fractionation, and after longer follow-up, hypofractionation wa
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Unkelbach, Jan, Dávid Papp, Melissa R. Gaddy, Nicolaus Andratschke, Theodore Hong, and Matthias Guckenberger. "Spatiotemporal fractionation schemes for liver stereotactic body radiotherapy." Radiotherapy and Oncology 125, no. 2 (2017): 357–64. http://dx.doi.org/10.1016/j.radonc.2017.09.003.

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Valdagni, Riccardo. "Altered Fractionation in Radiotherapy." Tumori Journal 84, no. 2 (1998): 155–59. http://dx.doi.org/10.1177/030089169808400211.

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Differences between late-responding (slowly proliferating) normal tissues and early-responding (rapidly proliferating) normal tissues and tumor cells and the event of tumor cell repopulation occurring during treatment have essentially led to the development of altered fractionation schemes. Altered fractionation regimens mainly refer to schedules utilising two or more (small dose) fractions per day for part of or for the entire treatment course. It must be underlined that a true standard or conventional fractionation regimen does not exist: no schedule is universally recognised as the standard
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Fallai, Carlo, and Patrizia Olmi. "Altered Fractionation Schedules in Radiotherapy of Head and Neck Cancer. A Review." Tumori Journal 78, no. 5 (1992): 311–25. http://dx.doi.org/10.1177/030089169207800506.

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The authors review the main contributions of international literature to show the current status in clinical trials on unconventional fractionations of the dose in radiotherapy of head and neck cancers. Several clinical (but only a few randomized) trials have been conducted over the last 15 years using hyperfractionated (HF), accelerated (AF) or mixed (HF-AF) schedules. HF schedules have obtained promising results in terms of local control in comparison with conventional fractionation (CF) of the dose. Improvement in survival was also obtained by the random trials of Pinto and Sanchiz, whereas
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Joseph, Nuradh, Norman F. Kirkby, Peter J. Hoskin, Catharine M. L. West, Ananya Choudhury, and Roger G. Dale. "Radiobiologically derived biphasic fractionation schemes to overcome the effects of tumour hypoxia." British Journal of Radiology 93, no. 1112 (2020): 20190250. http://dx.doi.org/10.1259/bjr.20190250.

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Objective: As a fractionated course of radiotherapy proceeds tumour shrinkage leads to resolution of hypoxia and the initiation of accelerated proliferation of radioresistant cancer cells with better repair capacity. We hypothesise that, in tumours with significant hypoxia, improved tumour control could be achieved with biphasic fractionation schedules that either use acceleration after 3–4 weeks of conventional radiotherapy or deliver a higher proportional dose towards the end of a course of treatment. We conducted a modelling study based on the concept of biological effective dose (BED) comp
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Chalimou, Ioanna, Helena Lind, Georgios C. Sakellaropoulos, et al. "Clinical survey for registering treatment decision criteria in advanced non-small-cell lung cancer radiotherapy and determination of the dose–response relationship for 1-year survival." Journal of Radiotherapy in Practice 13, no. 1 (2013): 18–28. http://dx.doi.org/10.1017/s1460396912000519.

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AbstractPurposeRecent studies have suggested significant variations in radiotherapy schedules used to treat advanced non-small-cell lung cancer (NSCLC), both between different centers in one country as well as between countries. In this study, different treatment methodologies have been explored using management plans proposed by radiation oncologists regarding general questions and theoretical case histories for patients with advanced NSCLC.Materials and methodsThe survey was conducted by sending a questionnaire to 24 radiotherapy centers in Europe. The questionnaire was composed of two secti
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Unkelbach, J., D. Papp, M. Gaddy, N. Andratschke, T. Hong, and M. Guckenberger. "PO-0900: Spatiotemporal fractionation schemes for liver stereotactic body radiotherapy." Radiotherapy and Oncology 127 (April 2018): S479—S480. http://dx.doi.org/10.1016/s0167-8140(18)31210-6.

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Dudley, Sara, Yushen Qian, Aadel Chaudhuri, Kiran Kumar, Sonya Aggarwal, and Daniel Tandel Chang. "Survival comparison of patients treated with one versus five fraction palliative radiotherapy." Journal of Clinical Oncology 33, no. 29_suppl (2015): 200. http://dx.doi.org/10.1200/jco.2015.33.29_suppl.200.

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200 Background: Choice of fractionation scheme for palliative radiotherapy has received greater attention in recent years, particularly in the current healthcare environment where issues of cost and quality of life have taken on increasing importance. The ASTRO Choosing Wisely campaign recommends against routine use of extended fractionation schemes ( > 10 fractions) for palliation of bone metastases given equivalent pain relief between 30 Gy in 10 fractions and 8 Gy in 1 fraction, and strong consideration for use of 8 Gy in 1 fraction is urged for patients with a limited prognosis or trans
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Dawson, George Anthony, Ignat Glushko, and Michael Philip Hagan. "A cross-sectional view of radiation fractionation schemes used for painful bone metastases (PBM) cases within the Veterans Health Administration Radiation Oncology Centers." Journal of Clinical Oncology 33, no. 29_suppl (2015): 177. http://dx.doi.org/10.1200/jco.2015.33.29_suppl.177.

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177 Background: Though the use of single fraction (SF) radiotherapy in the treatment of PBM is an integral component of frontline palliative radiotherapy in Canada and Europe ((Popovic - Radiotherapy and Oncology 111 (2014) 11–17), its use in the United States is only now gaining clinical acceptance. Recently, VHA Radiation Oncologists reported that roughly 76% offer SF to patients with a limited life expectancy (J Palliat Med. 2014 Nov;17(11):1221-5). In this cross-sectional report, we examine the actual dose fractionation schemes used for PBM cases by VHA Radiation Oncologists. Methods: METH
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Dissertations / Theses on the topic "Radiotherapy fractionation schemes"

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Hami, Abdoul-Azize Rihab. "Simulation des processus radiobiologiques basés sur l'imagerie pour l'évaluation de schémas thérapeutiques individualisés en radiothérapie." Electronic Thesis or Diss., Brest, 2024. http://www.theses.fr/2024BRES0002.

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La radiothérapie est l'un des principaux traitements du cancer. Malgré son utilisation intensive en pratique clinique, son efficacité dépend de plusieurs facteurs. Plusieurs études ont montré que la réponse tumorale à la radiothérapie diffère d'un patient à l'autre. En effet, la réponse de la tumeur est influencée par plusieurs facteurs comme l'hypoxie et des multiples interactions entre le microenvironnement tumoral et les cellules saines. Cinq concepts biologiques majeurs appelés les « 5 Rs » qui résument ces interactions ont vu le jour. Ces concepts incluent la réoxygénation, la réparation
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Book chapters on the topic "Radiotherapy fractionation schemes"

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Stuschke, Martin, and Christoph Pöttgen. "Altered Fractionation Schemes in Radiotherapy." In Frontiers of Radiation Therapy and Oncology. KARGER, 2009. http://dx.doi.org/10.1159/000262470.

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Unkelbach, J. "Non-uniform spatiotemporal fractionation schemes in photon radiotherapy." In IFMBE Proceedings. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-19387-8_97.

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Conference papers on the topic "Radiotherapy fractionation schemes"

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Batra, Ankit. "Clinical comparison of toxicity pattern of two linear quadratic model-baesd fractionation schemes of high-dose-rate intracavitary brachytherapy for cervical cancer." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685255.

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Introduction: Carcinoma cervix is the fourth (GLOBACON 2012) most common cancer among women worldwide, and the main cancer affecting women in Sub-Saharan Africa, Central America and south-central Asia. In India, approx. 1,23,000 (GLOBACON 2012) new cases of carcinoma cervix are diagnosed each year. Brachytherapy is an integral part of treatment of cancer cervix. In the context of a developing country like us where maximum utilization of the resource is of prime importance to provide treatment to the large patient cohort, shortening the treatment duration and number of fractions always increase
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Reports on the topic "Radiotherapy fractionation schemes"

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Skelly, Andrea C., Eric Chang, Jessica Bordley, et al. Radiation Therapy for Metastatic Bone Disease: Effectiveness and Harms. Agency for Healthcare Research and Quality (AHRQ), 2023. http://dx.doi.org/10.23970/ahrqepccer265.

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Objectives. To evaluate the comparative effectiveness and harms of external beam radiation therapy (EBRT) for palliative treatment of metastatic bone disease (MBD). Data sources. Four electronic databases from 1985 to January 30, 2023; a targeted search for re-irradiation through January 30, 2023; reference lists; and a Federal Register notice. Review methods. Using predefined criteria and dual review, we selected randomized controlled trials (RCTs) and nonrandomized studies of interventions (NRSIs) comparing dose-fractionation schemes and EBRT delivery techniques (for initial radiation and re
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