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Journal articles on the topic 'Radiotherapy fractionation schemes'

Author: Grafiati

Published: 7 July 2024

Last updated: 31 July 2025

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1

Kuznetsov, Maxim, and Andrey Kolobov. "Optimization of Dose Fractionation for Radiotherapy of a Solid Tumor with Account of Oxygen Effect and Proliferative Heterogeneity." Mathematics 8, no. 8 (2020): 1204. http://dx.doi.org/10.3390/math8081204.

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A spatially-distributed continuous mathematical model of solid tumor growth and treatment by fractionated radiotherapy is presented. The model explicitly accounts for three time and space-dependent factors that influence the efficiency of radiotherapy fractionation schemes—tumor cell repopulation, reoxygenation and redistribution of proliferative states. A special algorithm is developed, aimed at finding the fractionation schemes that provide increased tumor cure probability under the constraints of maximum normal tissue damage and maximum fractional dose. The optimization procedure is perform

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2

Antunac, Katarina, and Lidija Beketić-Orešković. "Breast cancer radiotherapy - changes in fractionation schemes through decades." Libri Oncologici Croatian Journal of Oncology 51, no. 1 (2023): 20–24. http://dx.doi.org/10.20471/lo.2023.51.01.03.

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Traditionally, as a standard dose fractionation schedule, adjuvant radiotherapy for breast cancer has been performed using prescribed doses of 46–50 Gy divided into daily fractions of 1.8–2 Gy. Overall, radiotherapy treatment took 5 weeks. In the 1990s, schedules using higher daily doses (2.5–3 Gy), a smaller number of fractions (hypofractionation), and a reduced overall prescribed dose started in the context of clinical trials. First results revealed an equivalent cosmetic effect of hypofractionated protocols compared to standard fractionation, and after longer follow-up, hypofractionation wa

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Unkelbach, Jan, Dávid Papp, Melissa R. Gaddy, Nicolaus Andratschke, Theodore Hong, and Matthias Guckenberger. "Spatiotemporal fractionation schemes for liver stereotactic body radiotherapy." Radiotherapy and Oncology 125, no. 2 (2017): 357–64. http://dx.doi.org/10.1016/j.radonc.2017.09.003.

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4

Valdagni, Riccardo. "Altered Fractionation in Radiotherapy." Tumori Journal 84, no. 2 (1998): 155–59. http://dx.doi.org/10.1177/030089169808400211.

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Differences between late-responding (slowly proliferating) normal tissues and early-responding (rapidly proliferating) normal tissues and tumor cells and the event of tumor cell repopulation occurring during treatment have essentially led to the development of altered fractionation schemes. Altered fractionation regimens mainly refer to schedules utilising two or more (small dose) fractions per day for part of or for the entire treatment course. It must be underlined that a true standard or conventional fractionation regimen does not exist: no schedule is universally recognised as the standard

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5

Fallai, Carlo, and Patrizia Olmi. "Altered Fractionation Schedules in Radiotherapy of Head and Neck Cancer. A Review." Tumori Journal 78, no. 5 (1992): 311–25. http://dx.doi.org/10.1177/030089169207800506.

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The authors review the main contributions of international literature to show the current status in clinical trials on unconventional fractionations of the dose in radiotherapy of head and neck cancers. Several clinical (but only a few randomized) trials have been conducted over the last 15 years using hyperfractionated (HF), accelerated (AF) or mixed (HF-AF) schedules. HF schedules have obtained promising results in terms of local control in comparison with conventional fractionation (CF) of the dose. Improvement in survival was also obtained by the random trials of Pinto and Sanchiz, whereas

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6

Joseph, Nuradh, Norman F. Kirkby, Peter J. Hoskin, Catharine M. L. West, Ananya Choudhury, and Roger G. Dale. "Radiobiologically derived biphasic fractionation schemes to overcome the effects of tumour hypoxia." British Journal of Radiology 93, no. 1112 (2020): 20190250. http://dx.doi.org/10.1259/bjr.20190250.

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Objective: As a fractionated course of radiotherapy proceeds tumour shrinkage leads to resolution of hypoxia and the initiation of accelerated proliferation of radioresistant cancer cells with better repair capacity. We hypothesise that, in tumours with significant hypoxia, improved tumour control could be achieved with biphasic fractionation schedules that either use acceleration after 3–4 weeks of conventional radiotherapy or deliver a higher proportional dose towards the end of a course of treatment. We conducted a modelling study based on the concept of biological effective dose (BED) comp

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Chalimou, Ioanna, Helena Lind, Georgios C. Sakellaropoulos, et al. "Clinical survey for registering treatment decision criteria in advanced non-small-cell lung cancer radiotherapy and determination of the dose–response relationship for 1-year survival." Journal of Radiotherapy in Practice 13, no. 1 (2013): 18–28. http://dx.doi.org/10.1017/s1460396912000519.

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AbstractPurposeRecent studies have suggested significant variations in radiotherapy schedules used to treat advanced non-small-cell lung cancer (NSCLC), both between different centers in one country as well as between countries. In this study, different treatment methodologies have been explored using management plans proposed by radiation oncologists regarding general questions and theoretical case histories for patients with advanced NSCLC.Materials and methodsThe survey was conducted by sending a questionnaire to 24 radiotherapy centers in Europe. The questionnaire was composed of two secti

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Unkelbach, J., D. Papp, M. Gaddy, N. Andratschke, T. Hong, and M. Guckenberger. "PO-0900: Spatiotemporal fractionation schemes for liver stereotactic body radiotherapy." Radiotherapy and Oncology 127 (April 2018): S479—S480. http://dx.doi.org/10.1016/s0167-8140(18)31210-6.

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9

Dudley, Sara, Yushen Qian, Aadel Chaudhuri, Kiran Kumar, Sonya Aggarwal, and Daniel Tandel Chang. "Survival comparison of patients treated with one versus five fraction palliative radiotherapy." Journal of Clinical Oncology 33, no. 29_suppl (2015): 200. http://dx.doi.org/10.1200/jco.2015.33.29_suppl.200.

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200 Background: Choice of fractionation scheme for palliative radiotherapy has received greater attention in recent years, particularly in the current healthcare environment where issues of cost and quality of life have taken on increasing importance. The ASTRO Choosing Wisely campaign recommends against routine use of extended fractionation schemes ( > 10 fractions) for palliation of bone metastases given equivalent pain relief between 30 Gy in 10 fractions and 8 Gy in 1 fraction, and strong consideration for use of 8 Gy in 1 fraction is urged for patients with a limited prognosis or trans

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Dawson, George Anthony, Ignat Glushko, and Michael Philip Hagan. "A cross-sectional view of radiation fractionation schemes used for painful bone metastases (PBM) cases within the Veterans Health Administration Radiation Oncology Centers." Journal of Clinical Oncology 33, no. 29_suppl (2015): 177. http://dx.doi.org/10.1200/jco.2015.33.29_suppl.177.

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177 Background: Though the use of single fraction (SF) radiotherapy in the treatment of PBM is an integral component of frontline palliative radiotherapy in Canada and Europe ((Popovic - Radiotherapy and Oncology 111 (2014) 11–17), its use in the United States is only now gaining clinical acceptance. Recently, VHA Radiation Oncologists reported that roughly 76% offer SF to patients with a limited life expectancy (J Palliat Med. 2014 Nov;17(11):1221-5). In this cross-sectional report, we examine the actual dose fractionation schemes used for PBM cases by VHA Radiation Oncologists. Methods: METH

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Mireștean, Camil Ciprian, Roxana Irina Iancu, and Dragoș Petru Teodor Iancu. "Active Immune Phenotype in Head and Neck Cancer: Reevaluating the Iso-Effect Fractionation Based on the Linear Quadratic (LQ) Model—A Narrative Review." Current Oncology 30, no. 5 (2023): 4805–16. http://dx.doi.org/10.3390/curroncol30050362.

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Altered fractionation concepts and especially moderate hypo-fractionation are evaluated as alternatives to standard treatment for head and neck squamous cell carcinoma (HNSCC), associated with or not concurrent with or sequential to chemotherapy. The calculation of the iso-equivalent dose regimens has as its starting point the linear quadratic (LQ) formalism traditionally based on the “4Rs” of radiobiology. The higher rates of therapeutic failure after radiotherapy of HNSCC are associated with the heterogeneity of radio-sensibility. The identification of genetic signatures and radio-resistance

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Unkelbach, Jan, Chuan Zeng, and Martijn Engelsman. "Simultaneous optimization of dose distributions and fractionation schemes in particle radiotherapy." Medical Physics 40, no. 9 (2013): 091702. http://dx.doi.org/10.1118/1.4816658.

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13

MIRESTEAN, Camil Ciprian, Alexandru Dumitru ZARA, Roxana Irina IANCU, and Dragos Petru Teodor IANCU. "Free Educational Android Mobile Application for Radiobiology." Medicina Moderna - Modern Medicine 28, no. 3 (2021): 315–19. http://dx.doi.org/10.31689/rmm.2021.28.3.315.

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The use of mobile devices and applications dedicated to different medical fields has improved the quality and facilitated medical care, especially in the last 10 years. The number of applications running on the software platforms of smart phones or other smart devices is constantly growing. Radiotherapy also benefits from applications (apps) for TNM staging of cancers, for target volume delineation and toxicity management but also from radiobiological apps for calculating equivalent dose schemes for different dose fractionation regimens. In the context of the increasingly frequent use of alter

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MIRESTEAN, Camil Ciprian, Alexandru Dumitru ZARA, Roxana Irina IANCU, and Dragos Petru Teodor IANCU. "Free Educational Android Mobile Application for Radiobiology." Medicina Moderna - Modern Medicine 28, no. 3 (2021): 315–19. http://dx.doi.org/10.31689/rmm.2021.28.3.315.

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The use of mobile devices and applications dedicated to different medical fields has improved the quality and facilitated medical care, especially in the last 10 years. The number of applications running on the software platforms of smart phones or other smart devices is constantly growing. Radiotherapy also benefits from applications (apps) for TNM staging of cancers, for target volume delineation and toxicity management but also from radiobiological apps for calculating equivalent dose schemes for different dose fractionation regimens. In the context of the increasingly frequent use of alter

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15

Jiménez Cantero, Adriana, Jessica Chávez Nogueda, Fabiola Flores Vázquez, José Pablo Castillo de la Garza, Raymundo Hernández Montes de Oca, and Alejandro Olmos Guzmán. "Hypofractioned radiotherapy versus conventional radiotherapy for the treatment of multiform glioblastoma in adults over 70 years old." Journal of Radiotherapy in Practice 19, no. 2 (2019): 193–96. http://dx.doi.org/10.1017/s146039691900044x.

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AbstractAim:Multiform glioblastoma (MG) represents 70% of all gliomas, with half of patients older than 65 years with median survival of 12–18 months, hypofractionation seeks to reduce the intensity and duration of treatment without impacting on survival rates. The objective was to determine the global survival and recurrence-free survival of adults over 70 years old with MG treated with hypofractionated radiotherapy and standard scheme. The review of patients older than 70 years treated with radiotherapy from 2013 to 2016 was performed.Results:Twenty-four patients were analysed, with a median

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16

Liew, Hans, Stewart Mein, Thomas Tessonnier, et al. "Do We Preserve Tumor Control Probability (TCP) in FLASH Radiotherapy? A Model-Based Analysis." International Journal of Molecular Sciences 24, no. 6 (2023): 5118. http://dx.doi.org/10.3390/ijms24065118.

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Reports of concurrent sparing of normal tissue and iso-effective treatment of tumors at ultra-high dose-rates (uHDR) have fueled the growing field of FLASH radiotherapy. However, iso-effectiveness in tumors is often deduced from the absence of a significant difference in their growth kinetics. In a model-based analysis, we investigate the meaningfulness of these indications for the clinical treatment outcome. The predictions of a previously benchmarked model of uHDR sparing in the “UNIfied and VERSatile bio response Engine” (UNIVERSE) are combined with existing models of tumor volume kinetics

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17

Singh, Gaganpreet, Rose Kamal, Deepak Thaper, et al. "Voxel based evaluation of sequential radiotherapy treatment plans with different dose fractionation schemes." British Journal of Radiology 93, no. 1112 (2020): 20200197. http://dx.doi.org/10.1259/bjr.20200197.

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Objective: This study presents a methodology for voxel-based evaluation of two phase sequential radiotherapy treatment plans having conventional dose scheme in the first phase and subsequent hypofractionation dose scheme in the second phase based upon different priority [planning target volume (PTV), clinical target volume (CTV) and organs at risk (OAR)] of display modes. Methods: A case of carcinoma prostate was selected for demonstration. Varian Eclipse treatment planning system (TPS) was used for contouring and planning. In the first phase, a dose of 52 Gy in 26 fractions to the PTV and in

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Qureshy, Sarah A., Marshall A. Diven, Xiaoyue Ma, et al. "Differential Use of Radiotherapy Fractionation Regimens in Prostate Cancer." JAMA Network Open 6, no. 10 (2023): e2337165. http://dx.doi.org/10.1001/jamanetworkopen.2023.37165.

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ImportanceTechnical advances in treatment of prostate cancer and a better understanding of prostate cancer biology have allowed for hypofractionated treatment courses using a higher dose per fraction. Use of ultrahypofractionated stereotactic body radiotherapy (SBRT) has also been characterized.ObjectiveTo characterize US national trends of different RT fractionation schemes across risk groups of prostate cancer.Design, Setting, and ParticipantsThis retrospective cohort study used data collected by the National Cancer Database (NCDB) to characterize the fractionation regimens used for 302 035

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Ma, Ting Martin, Oscar Lilleby, Wolfgang A. Lilleby, and Amar U. Kishan. "Ablative Radiotherapy in Prostate Cancer: Stereotactic Body Radiotherapy and High Dose Rate Brachytherapy." Cancers 12, no. 12 (2020): 3606. http://dx.doi.org/10.3390/cancers12123606.

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Prostate cancer (PCa) is the most common noncutaneous solid organ malignancy among men worldwide. Radiation therapy is a standard of care treatment option that has historically been delivered in the form of small daily doses of radiation over the span of multiple weeks. PCa appears to have a unique sensitivity to higher doses of radiation per fraction, rendering it susceptible to abbreviated forms of treatment. Stereotactic body radiation therapy (SBRT) and high-dose-rate brachytherapy (HDRBT) are both modern radiation modalities that allow the precise delivery of ablative doses of radiation t

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Woody, Neil M., Gregory M. M. Videtic, Kevin L. Stephans, Toufik Djemil, Yongbok Kim, and Ping Xia. "Predicting Chest Wall Pain From Lung Stereotactic Body Radiotherapy for Different Fractionation Schemes." International Journal of Radiation Oncology*Biology*Physics 83, no. 1 (2012): 427–34. http://dx.doi.org/10.1016/j.ijrobp.2011.06.1971.

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21

Horiot, J. C., P. Bontemps, A. C. Begg, et al. "New radiotherapy fractionation schemes in head and neck cancers. The EORTC trials: A benchmark." European Journal of Cancer 33 (September 1997): S133. http://dx.doi.org/10.1016/s0959-8049(97)85138-6.

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22

Mayer, Árpád, and Zsuzsa Póti. "Novel irradiation techniques in the treatment of solid tumours. Radiotherapy of metastases." Orvosi Hetilap 155, no. 8 (2014): 283–90. http://dx.doi.org/10.1556/oh.2014.29832.

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Novel developments in percutaneous radiotherapy, such as positron emission tomography/computed tomography, adaptive radiation planning, intensity modulation radiotherapy and intensity modulated arc therapy (RapidArc), as well as the newer generation of image control (cone-beam computed tomography) and image guided radiotherapy ensure increased dosages of planning target volume and clinical target volume of solid tumours without damaging surrounding tissues and providing maximal protection. By raising the dosages of planned target volume and clinical target volume, these novel technical develop

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Nikzad, Safoora, Bijan Hashemi, Golshan Mahmoudi, and Milad Baradaran-Ghahfarokhi. "Estimation of cell response in fractionation radiotherapy using different methods derived from linear quadratic model." Radiology and Oncology 49, no. 4 (2015): 347–56. http://dx.doi.org/10.1515/raon-2015-0040.

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Abstract Background. The aim of this study was to use various theoretical methods derived from the Linear Quadratic (LQ) model to calculate the effects of number of subfractions, time intervals between subfractions, dose per subfraction, and overall fraction time on the cells’ survival. Comparison of the results with experimental outcomes of melanoma and breast adenocarcinoma cells was also performed. Finally, the best matched method with experimental outcomes is introduced as the most accurate method in predicting the cell response. Materials and methods. The most widely used theoretical meth

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Kamel, Randa, Tinghua Zhang, Suzanne Comino, and Kristopher Dennis. "A 15-Year Single-Institution Retrospective Study of Primary Pancreatic Cancer Treated with Non-Ablative Palliative Radiotherapy." Cancers 16, no. 5 (2024): 881. http://dx.doi.org/10.3390/cancers16050881.

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We studied the use of palliative radiotherapy (RT) among patients with primary, non-curable, locally advanced pancreatic cancer. In this subset of patients, with very poor survival, various palliative RT dose fractionation schemes are used; but, in the absence of a guideline, practice patterns vary, and dose choice is mainly based on the physician’s intuition. We divided the patients into three groups, according to the dose fractionation schedules received: low (A), intermediate (B), and high (C) dose groups, to study the potential differences in outcome between the different dose prescription

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Borm, Kai J., Johanne Kleine Vennekate, Jan Vagedes, et al. "A Comprehensive Prospective Comparison of Acute Skin Toxicity after Hypofractionated and Normofractionated Radiation Therapy in Breast Cancer." Cancers 13, no. 22 (2021): 5826. http://dx.doi.org/10.3390/cancers13225826.

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The current study aims to determine whether hypofractionated radiotherapy (HF) leads to lower rates of acute radiodermatitis compared to conventional normofractionated radiotherapy (CF). A total of 166 patients with invasive breast cancer or DCIS were included in a prospective cohort study. Evaluation of acute radiodermatitis was obtained before radiotherapy, at the end of the treatment (T1), and 6 weeks after the treatment (T2) using CTCAE (v5.0) scores, the Skindex-16 questionnaire, and ultrasound measurement of the skin. CTCAE and Skindex-16 scores in the CF-group were significantly higher

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Ferini, Gianluca, Antonella Tripoli, Vincenza Umina, et al. "Radiation Proctitis: The Potential Role of Hyaluronic Acid in the Prevention and Restoration of Any Damage to the Rectal Mucosa among Prostate Cancer Patients Submitted to Curative External Beam Radiotherapy." Gastroenterology Insights 12, no. 4 (2021): 446–55. http://dx.doi.org/10.3390/gastroent12040043.

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Aim: To evaluate if hyaluronic acid reduces proctitis episodes with respect to corticosteroids in prostate cancer patients submitted to radical or adjuvant radiotherapy. Methods: A consecutive series of eligible patients received hyaluronic acid enemas as supportive care (experimental group, from January 2013 to June 2015). A historical group (control group), treated from October 2011 to December 2012, received beclomethasone dipropionate suppositories. We registered each patient’s data regarding acute and chronic proctitis. All patients were treated with static-intensity-modulated radiotherap

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Shirvani, Shervin M., Calvin J. Huntzinger, Thorsten Melcher, et al. "Biology-guided radiotherapy: redefining the role of radiotherapy in metastatic cancer." British Journal of Radiology 94, no. 1117 (2021): 20200873. http://dx.doi.org/10.1259/bjr.20200873.

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The emerging biological understanding of metastatic cancer and proof-of-concept clinical trials suggest that debulking all gross disease holds great promise for improving patient outcomes. However, ablation of multiple targets with conventional external beam radiotherapy systems is burdensome, which limits investigation and utilization of complete metastatic ablation in the majority of patients with advanced disease. To overcome this logistical hurdle, technical innovation is necessary. Biology-guided radiotherapy (BgRT) is a new external beam radiotherapy delivery modality combining positron

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Falkson, C. B., E. T. Vella, E. Yu, et al. "Guideline for radiotherapy with curative intent in patients with early stage, medically inoperable, non-small cell lung cancer." Current Oncology 24, no. 1 (2017): 44. http://dx.doi.org/10.3747/co.24.3358.

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Objectives For this guideline, we investigated the effectiveness of radiotherapy with curative intent in medically inoperable patients with early-stage non-small-cell lung cancer (nsclc).Methods The guideline was developed by Cancer Care Ontario’s Program in Evidence-Based Care and by the Lung Cancer Disease Site Group through a systematic review of mainly retrospective studies, expert consensus, and formal internal and external reviews.RecommendationsStereotactic body radiation therapy (sbrt) with curative intent is an option that should be considered for patients with early-stage, node-negat

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de Jong, Anouk, Fia Cialdella, Arthur van der Boog, et al. "RADT-34. RE-IRRADIATION REGIMENS FOR RECURRENT GLIOMA: SURVIVAL AND TOXICITY." Neuro-Oncology 26, Supplement_8 (2024): viii80. http://dx.doi.org/10.1093/neuonc/noae165.0318.

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Abstract Re-irradiation is a common treatment option for recurrent high-grade glioma (HGG), though the optimal dose-fractionation regimen remains unclear. This report presents single-center data from an ongoing multicenter, retrospective study in the Netherlands. We included adult HGG patients treated with re-irradiation. Dose-fractionation regimens were categorized in 3 groups: conventionally fractionated radiotherapy (CFRT, &lt;3Gy/fraction), hypofractionated radiotherapy (HFRT, 3-5 Gy/fraction) and stereotactic radiotherapy (SRT, ≥5Gy/fraction). We compared baseline characteristics, ove

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Stolz, Jessica, Kristina Rogal, Sandra Bicher, et al. "The Combination of Temporal and Spatial Dose Fractionation in Microbeam Radiation Therapy." Biomedicines 13, no. 3 (2025): 678. https://doi.org/10.3390/biomedicines13030678.

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Background: Microbeam radiation therapy (MRT) is an advanced preclinical approach in radiotherapy that utilizes spatially fractionated dose distributions by collimating x-rays into micrometer-wide, planar beams. While the benefits of temporal fractionation are well established and widely incorporated into conventional radiotherapy protocols, the interplay between MRT and temporal dose fractionation remains largely unexplored. In this study, we investigate the effects of combining temporal and spatial dose fractionation by assessing clonogenic cell survival following temporally fractionated MRT

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Ibrahim, Hassan, and Usman Bello. "Dose Fractionation Schemes for Palliative External Beam Radiotherapy on Painful Bone Metastasis from Breast Cancer." Borno Medical Journal 17, no. 1 (2020): 1–9. http://dx.doi.org/10.31173/bomj.bomj_135_17.

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Hamilton, Julie, Geoff Higgins, and Eric Bernhard. "Conventional radiotherapy or hypofractionation? A study of molecular changes resulting from different radiation fractionation schemes." Cancer Biology & Therapy 8, no. 9 (2009): 774–76. http://dx.doi.org/10.4161/cbt.8.9.8341.

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Fallai, Carlo, Patrizia Olmi, and Enrico Cellai. "Advanced carcinomas of the oropharynx treated with radiotherapy—A comparison of three different fractionation schemes." American Journal of Otolaryngology 14, no. 1 (1993): 31–37. http://dx.doi.org/10.1016/0196-0709(93)90007-t.

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Moore, Assaf, Robert Benjamin Den, Noa Gordon, et al. "The financial impact of fractionation scheme and treatment planning method for rectal cancer in the United States." Journal of Clinical Oncology 37, no. 15_suppl (2019): 6518. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.6518.

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6518 Background: Preoperative long-course chemoradiotherapy (CRT) and short-course radiotherapy (SCR) for locally advanced rectal cancer (LARC) were found to have equivalent outcomes in three randomized trials. SCR may have lower acute toxicity and the down-staging following CRT is more well-established. At present, SCR is frequently used in Europe but has not been widely adopted in the United States (US). It is standard to deliver radiotherapy by 3D planning, while the use of Intensity-modulated radiotherapy (IMRT) is controversial. In recent years there has been an increasing focus on unders

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Vetrugno, Irene, Irma Telarovic, Nathan Torelli, Jan Unkelbach, and Martin Pruschy. "Abstract 2879: Spatiotemporal fractionation: An innovative concept of fractionated radiotherapy." Cancer Research 84, no. 6_Supplement (2024): 2879. http://dx.doi.org/10.1158/1538-7445.am2024-2879.

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Abstract Impressive outcomes in therapeutic radiation oncology have been achieved in the past decade through the development of advanced computer technology and imaging methods, such as intensity modulated radiotherapy. Ideally, radiotherapy treatment delivers a high dose to the tumor while sparing the surrounding healthy tissues and organs at risk from radiation damage. Spatiotemporal Fractionated Radiotherapy has emerged as an innovative technique that delivers different dose distributions to different parts of the tumor in order to achieve high doses to the target while ensuring a low dose-

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Brizel, David M., and Ramon Esclamado. "Concurrent Chemoradiotherapy for Locally Advanced, Nonmetastatic, Squamous Carcinoma of the Head and Neck: Consensus, Controversy, and Conundrum." Journal of Clinical Oncology 24, no. 17 (2006): 2612–17. http://dx.doi.org/10.1200/jco.2005.05.2829.

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Radiotherapy and concurrent chemotherapy (CRT) is superior to radiotherapy alone for the treatment of locally advanced, nonmetastatic squamous carcinoma of the head and neck (HNC). Three issues affect the use of CRT as primary treatment for advanced HNC. The first issue is the definition of advanced stage and the initial therapeutic choice of surgery or CRT and the role of post-CRT neck dissection. Function preservation considerations should guide the choice between surgery and CRT for patients with resectable disease. Fluorodeoxyglucose–positron emission tomography scanning may identify patie

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Wu, Jia-Ming, Yan-Cheng Ye, and Yan-Shan Zhang. "BIOLOGICAL EQUALIZATION DOSE INVESTIGATION FOR CARBON-ION RADIOTHERAPY (BEDC) IN DIFFERENT FRACTIONATION SCHEMES AND FRACTION DOSES." International Journal of Particle Therapy 12 (June 2024): 100234. http://dx.doi.org/10.1016/j.ijpt.2024.100234.

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Stephans, K., N. M. Woody, G. M. M. Videtic, T. Djemil, and P. Xia. "Chest Wall Toxicity from Lung Stereotactic Body Radiotherapy (SBRT): A Dosimetric Analysis using Several Fractionation Schemes." International Journal of Radiation Oncology*Biology*Physics 78, no. 3 (2010): S506. http://dx.doi.org/10.1016/j.ijrobp.2010.07.1182.

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DeAngelis, Lisa M., Lynda R. Mandell, H. Tzvi Thaler, et al. "The Role of Postoperative Radiotherapy after Resection of Single Brain Metastases." Neurosurgery 24, no. 6 (1989): 798–805. http://dx.doi.org/10.1227/00006123-198906000-00002.

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ABSTRACT To assess the value of whole brain radiotherapy (WBRT) after complete resection of a single brain metastasis we reviewed the records of 98 patients who had elective craniotomy between 1978 and 1985. Seventy-nine patients received postoperative WBRT (Group A) and 19 patients no radiotherapy (RT) (Group B). Neurological relapse was designated as local (i.e., at the site of the original metastasis) or distant (i.e., elsewhere in the brain). Postoperative WBRT significantly prolonged the time to any neurological relapse (P = 0.034) with a 1-year recurrence rate of 22% in Group A and 46% i

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Antipas, V. P., N. K. Uzunoglu, and G. S. Stamatakos. "A Patient-specific in vivo Tumor and Normal Tissue Model for Prediction of the Response to Radiotherapy." Methods of Information in Medicine 46, no. 03 (2007): 367–75. http://dx.doi.org/10.1160/me0312.

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Summary Objectives: Integration of multiscale experimental cancer biology through the development of computer simulation models seems to be a necessary step towards the better understanding of cancer and patient-individualized treatment optimization. The integration of a four-dimensional patient-specific model of in vivo tumor response to radiotherapy developed by our group with a model of slowly responding normal tissue based on W. Duechting’s approach is presented in this paper. The case of glioblastoma multiforme and its surrounding neural tissue is addressed as a modeling paradigm. Methods

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Kraszkiewicz, M., A. Napieralska, J. Wydmański, R. Suwiński, and W. Majewski. "Evaluation of Efficacy and Tolerance of Radical Radiotherapy and Radiochemotherapy in Treatment of Locally Advanced, Unresectable Rectal Cancer." Technology in Cancer Research & Treatment 21 (January 2022): 153303382210860. http://dx.doi.org/10.1177/15330338221086085.

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Background: A retrospective evaluation of tolerance and efficacy of two schemes of neoadjuvant treatment in patients (pts) with unresectable rectal cancer: radiochemotherapy (CRT) and radiotherapy (RT), including conventional and accelerated hyperfractionation. Material and Method: A total of 145 consecutive pts with unresectable, locally advanced rectal cancer. The schemes used are RT in 73 (50%) or CRT in 72 (50%). In CRT, 54 Gy in 1.8 Gy fractions was given with chemotherapy, In the RT group, conventional fractionation (CFRT) and hyperfractionated accelerated radiotherapy (HART). HART was i

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Rodrigues, M., P. Teles, R. Pirraco, D. Oliveira, and P. Costa. "Evaluation of fractionation schemes in breast cancer radiotherapy and dosimetric study of the main organs at risk." Physica Medica 92 (December 2021): S185. http://dx.doi.org/10.1016/s1120-1797(22)00396-9.

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Graham, PH, WJ Morris, and P. Pickles. "Four-week arc radiotherapy for B2-Cprostate cancer: The need for prospective evaluation of short fractionation schemes." Australasian Radiology 41, no. 3 (1997): 266–69. http://dx.doi.org/10.1111/j.1440-1673.1997.tb00671.x.

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Machado, Bruno da Silva, Gustavo Benitez Alvarez, and Diomar Cesar Lobão. "Reactive-Advective-Diffusive Models for the Growth of Gliomas Treated with Radiotherapy." Semina: Ciências Exatas e Tecnológicas 44 (June 22, 2023): e47321. http://dx.doi.org/10.5433/1679-0375.2023.v44.47321.

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Gliomas are malignant brain tumors responsible for 50% of primary human brain cancer cases. They have a combination of rapid growth and invasiveness, and high fatality rates with a median survival time of one year. Mathematical models that describe its growth have helped to improve treatment. In this paper, a combined model formed by terms of two other models known in the literature is analyzed. The combined model is a Reactive-Advective-Diffusive partial differential equation, which is solved by combining the finite difference method, the Crank-Nicolson method and the upwind method. Logistic

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Arsenev, Andrey, Sergey Novikov, Sergey Kanaev, et al. "STEREOTACTIC BODY RADIATION THERAPY FOR EARLY-STAGE NON-SMALL CELL LUNG CANCER." Problems in oncology 64, no. 5 (2018): 638–44. http://dx.doi.org/10.37469/0507-3758-2018-64-5-638-644.

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An active introduction of screening programs potentially leads to a significant increase in the proportion of patients with early forms of non-small cell lung cancer. Surgical treatment, which is the standard of care for localized forms, due to functional limitations can be performed only in 65-70% of patients. The solution to this problem can be found in the improvement of the results of radiotherapy by using modern equipment, the planning systems, improved fractionation schemes and introduction of methods for summing radiation doses. Stereotactic radiotherapy allows high-precision delivery o

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Passi, Kamlesh, Than S. Kehwar, Rajesh Vashistha, Bikramjit Singh, Veena Jain, and Sureshchandra J. Gupta. "High-dose-rate brachytherapy with external beam radiotherapy in the treatment of carcinoma of cervix: dosimetric and radiobiologic analysis." Journal of Radiotherapy in Practice 8, no. 4 (2009): 215–27. http://dx.doi.org/10.1017/s1460396909990021.

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AbstractPurpose: The aim of this study was to find out equivalency between two high-dose-rate (HDR) fractionation schemes, relevance to the International Commission on Radiation Units and Measurements report-38 (ICRU-38) reference volume with respect to point A dose and other ICRU reference points in two-dimensional (2D) planning.Methods and Materials: Forty-nine patients having carcinoma of cervix of stages II–IIIB treated with external beam radiotherapy plus HDR brachytherapy (BT) were analysed. The external beam radiotherapy dose of 45 Gy/25 fractions delivered in 5 weeks followed by HDR BT

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Ohtakara, Kazuhiro, and Hiroaki Hoshi. "Gradual Recovery from Nonambulatory Quadriparesis Caused by Metastatic Epidural Cervical Cord Compression in an Octogenarian Gallbladder Carcinoma Patient Treated with Image-Guided Three-Dimensional Conformal Radiotherapy Alone Using a Field-in-Field Technique." Case Reports in Oncological Medicine 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/398208.

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Radiotherapy for acute metastatic epidural spinal cord compression (MESCC) involves conventional techniques and dose fractionation schemes, as it needs to be initiated quickly. However, even with rapid intervention, few paraplegic patients regain ambulation. Here, we describe the case of a mid-octogenarian who presented with severe pain and nonambulatory quadriparesis attributable to MESCC at the fifth cervical vertebra, which developed 10 months after the diagnosis of undifferentiated carcinoma of the gallbladder. Image-guided three-dimensional conformal radiotherapy (IG-3DCRT) was started wi

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Horas, Jorge A., Osvaldo R. Olguín, and Marcos G. Rizzotto. "Examining the validity of Poissonian models against the birth and death TCP model for various radiotherapy fractionation schemes." International Journal of Radiation Biology 86, no. 8 (2010): 711–17. http://dx.doi.org/10.3109/09553001003734618.

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Alomari, Omar, Hüseyin Tepetam, Şule Karabulut Gül, et al. "COMPARISON OF RADIOTHERAPY FRACTIONATION SCHEMES AND ADJUVANT ANTI-HER2 THERAPIES ON CARDIOTOXICITY IN HER2-POSITIVE BREAST CANCER PATIENTS." Journal of the American College of Cardiology 85, no. 12 (2025): 4684. https://doi.org/10.1016/s0735-1097(25)05168-x.

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Moore, Assaf, Ido Stav, Robert B. Den, et al. "The Financial Impact of Hypofractionated Radiation for Localized Prostate Cancer in the United States." Journal of Oncology 2019 (January 2, 2019): 1–8. http://dx.doi.org/10.1155/2019/8170428.

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Background. Until recently, dose intensified radiotherapy was the standard radiation method for localized prostate cancer. Multiple studies have demonstrated similar efficacy and tolerability with moderate hypofractionation. In recent years there has been an increasing focus placed on understanding the cost and value of cancer care. In this study we aimed to assess the economic impact of moderate hypofractionation for payers in the United States.Methods. We performed a population-based analysis of the total cost of external beam radiotherapy (EBRT) for localized prostate cancer in the US annua

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