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Journal articles on the topic 'RADIUM 228'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Szerbin, P., and D. K. Popov. "Transfer of radium-228, thorium-228 and radium-226 from forage to cattle and reindeer." Journal of Environmental Radioactivity 8, no. 2 (1988): 129–41. http://dx.doi.org/10.1016/0265-931x(88)90021-5.

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2

Smith, M. R., A. W. Lautensleger, and J. C. Laul. "A new method for the determination of radium-228, thorium-228, and radium-224 in groundwaters via thoron (radon-220)." Journal of Radioanalytical and Nuclear Chemistry Articles 123, no. 1 (1988): 107–19. http://dx.doi.org/10.1007/bf02036384.

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3

Miner, Gary. "Fast Testing Method Developed for Radium 226/228." Journal - American Water Works Association 100, no. 3 (2008): 56–57. http://dx.doi.org/10.1002/j.1551-8833.2008.tb09576.x.

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4

Sidhu, K. S., and M. S. Breithart. "Naturally Occurring Radium-226 and Radium-228 in Water Supplies of Michigan." Bulletin of Environmental Contamination and Toxicology 61, no. 6 (1998): 722–29. http://dx.doi.org/10.1007/s001289900821.

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5

Cook, M., and R. Kleinschmidt. "Simultaneous Determination of 226Ra and 228Ra in Water by Liquid Scintillation Spectrometry." Australian Journal of Chemistry 64, no. 7 (2011): 880. http://dx.doi.org/10.1071/ch11120.

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Radium is a naturally occurring alkaline earth metal that is present in soils, water, plants, and foods in low concentrations. In the analysis of radium in trace amounts, co-precipitation is the favoured way of separating an element from its matrix. In this case, radium is co-precipitated with barium. The purity and yield of the extraction is controlled by adsorption onto the barium sulfate precipitate and pH manipulation controls the solubility of certain products. This technique enables the removal of interfering lead-210 to yield a purified radium source for analysis, which is done using li

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6

Hsieh, Yu-Te, Walter Geibert, Pieter van-Beek, Henrik Stahl, Dmitry Aleynik, and Gideon M. Henderson. "Using the radium quartet (228 Ra, 226 Ra, 224 Ra, and 223 Ra) to estimate water mixing and radium inputs in Loch Etive, Scotland." Limnology and Oceanography 58, no. 3 (2013): 1089–102. http://dx.doi.org/10.4319/lo.2013.58.3.1089.

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7

Dias, Thais H., Joselene de Oliveira, Christian J. Sanders, et al. "Radium isotope ( 223 Ra, 224 Ra, 226 Ra and 228 Ra) distribution near Brazil's largest port, Paranaguá Bay, Brazil." Marine Pollution Bulletin 111, no. 1-2 (2016): 443–48. http://dx.doi.org/10.1016/j.marpolbul.2016.07.004.

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8

Moore, Willard S. "Radium 228 in the South Atlantic Bight." Journal of Geophysical Research 92, no. C5 (1987): 5177. http://dx.doi.org/10.1029/jc092ic05p05177.

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9

Abbasi, Akbar. "A review of the analytical methodology to determine Radium-226 and Radium-228 in drinking waters." Radiochimica Acta 106, no. 10 (2018): 819–29. http://dx.doi.org/10.1515/ract-2018-2967.

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Abstract Radium-228 (228Ra) and Radium-226 (226Ra) isotopes in drinking water are significant from the aspect of radiation protection and human health. In this paper, the three most common preconcentration methods, i.e.coprecipitation, absorption and evaporation, were reviewed with emphasis on routinely measurement techniques. The reviewed measurement techniques include low background γ-spectrometry, α-spectrometry and liquid scintillation counting. The γ-spectrometry technique is the good selection, when the maximum sensitivity is considered. The Environmental Protection Agency guideline has

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10

Mangeret, Arnaud, Jean-Louis Reyss, Marina Seder-Colomina, et al. "Early diagenesis of radium 226 and radium 228 in lacustrine sediments influenced by former mining sites." Journal of Environmental Radioactivity 222 (October 2020): 106324. http://dx.doi.org/10.1016/j.jenvrad.2020.106324.

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11

Aleissa, Khalid A., Fahad I. Almasoud, Mohammed S. Islam, and Michael F. L’Annunziata. "Radium-228 analysis of natural waters by Cherenkov counting of Actinium-228." Applied Radiation and Isotopes 66, no. 12 (2008): 1954–63. http://dx.doi.org/10.1016/j.apradiso.2008.05.012.

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12

Orr, James C. "Evaluation of counting methods for oceanic radium-228." Journal of Geophysical Research 93, no. C7 (1988): 8265. http://dx.doi.org/10.1029/jc093ic07p08265.

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13

Dowdall, M., and Aivo Lepland. "Elevated levels of radium-226 and radium-228 in marine sediments of the Norwegian Trench (“Norskrenna”) and Skagerrak." Marine Pollution Bulletin 64, no. 10 (2012): 2069–76. http://dx.doi.org/10.1016/j.marpolbul.2012.07.022.

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14

Dalencourt, Claire, Annie Michaud, Azza Habibi, Alexa Leblanc, and Dominic Larivière. "Rapid, versatile and sensitive method for the quantification of radium in environmental samples through cationic extraction and inductively coupled plasma mass spectrometry." Journal of Analytical Atomic Spectrometry 33, no. 6 (2018): 1031–40. http://dx.doi.org/10.1039/c8ja00060c.

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Rapid and selective method for radium quantification with interference removal by cationic resin and ICP-MS/MS, leading to a detection limit of 10 fg L<sup>−1</sup> for <sup>226</sup>Ra and <sup>228</sup>Ra.

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15

Zawadzki, Atun, Megan Cook, Brodie Cutmore, et al. "Comparison of radium-228 determination in water among Australian laboratories." Journal of Environmental Radioactivity 178-179 (November 2017): 411–18. http://dx.doi.org/10.1016/j.jenvrad.2017.05.012.

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16

Pereira, Wagner de S., Alphonse Kelecom, and Delcy de A. Py Júnior. "Activity of natural radionuclides and their contribution to the absorbed dose in the fish cubera snapper (lutjanus cyanopterus, cuvier, 1828) on the coast of Ceara, Brazil." Brazilian Journal of Oceanography 58, spe4 (2010): 25–32. http://dx.doi.org/10.1590/s1679-87592010000800005.

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A methodology was developed for converting the activity concentration of radionuclides (Bq kg-1) into absorbed dose rate (Gy y-1), aiming an approach to environmental radioprotection based on the concept of standard dose limit. The model considers only the internal absorbed dose rate. This methodology was applied to the cubera snapper fish (Lutjanus cyanopterus, Cuvier, 1828) caught off the coast of Ceará. The natural radionuclides considered were uranium-238, radium-226, lead-210, thorium-232 and radium-228. The absorbed dose rates were calculated for individual radionuclides and the type of

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17

Liu, Yi, Jiu Jimmy Jiao, Rong Mao, Xin Luo, Wenzhao Liang, and Clare E. Robinson. "Spatial Characteristics Reveal the Reactive Transport of Radium Isotopes ( 224 Ra, 223 Ra, and 228 Ra) in an Intertidal Aquifer." Water Resources Research 55, no. 12 (2019): 10282–302. http://dx.doi.org/10.1029/2019wr024849.

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18

Paige, C. R., W. A. Kornicker, O. E. Hileman, and W. J. Snodgrass. "The Preparation of Carrier-Free Radium-228 Using Cation Exchange Columns." International Journal of Environmental Analytical Chemistry 37, no. 1 (1989): 29–34. http://dx.doi.org/10.1080/03067318908026882.

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19

Ebaid, Yasser Y., Yasser Hassan, and Wael M. Elshemey. "RADIOECOLOGICAL IMPACT AND THE ASSOCIATED HAZARDS DUE TO NORM FROM OIL AND GAS PRODUCTION FACILITY IN THE WESTERN DESERT OF EGYPT." Radiation Protection Dosimetry 190, no. 2 (2020): 165–75. http://dx.doi.org/10.1093/rpd/ncaa084.

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Abstract An oil and gas production facility in the western desert of Egypt was investigated for possible radiation risks due to the routine operation. Radium-226, Radium-228 and Potassium-40 were assessed in the soil samples collected from the adjacent soakaway pond. The average 226Ra, 228Ra and 40K activity concentrations were 881.0 ± 42.0, 966.0 ± 43.0 and 143.0 ± 8.0 Bq kg−1, respectively. Both 226Ra and 228Ra were above the world ranges, while 40K was within the world range. Water samples from the facilities effluent’s produced water showed elevated levels of both radium isotopes. The effe

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20

Jiang, Xue Yan, Sarah Atkinson, Sam Cuming, et al. "Radium 223 treatment in metastatic castrate-resistant prostate cancer: Impact of sequencing on survival—Real-world outcomes from a single United Kingdom center." Journal of Clinical Oncology 37, no. 7_suppl (2019): 223. http://dx.doi.org/10.1200/jco.2019.37.7_suppl.223.

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223 Background: Radium 223 (Ra-223) is a FDA and EMA approved alpha particle radiopharmaceutical used to treat men with metastatic castrate resistant prostate cancer (mCRPC) with symptomatic bone metastasis. In view of emerging systemic options, new EMA 2018 licence indication is for 3rd line onwards. We aim to evaluate the impact of systemic therapy sequencing on survival outcomes from a heterogeneous cohort of 228 patients treated with Ra-223 in a single UK centre. Methods: We prospectively collected data from 228 men underwent Ra-223 therapy for mCRPC between April 2014 and August 2018. Sur

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21

Hsieh, Yu-Te, Walter Geibert, E. Malcolm S. Woodward, et al. "Radium-228-derived ocean mixing and trace element inputs in the South Atlantic." Biogeosciences 18, no. 5 (2021): 1645–71. http://dx.doi.org/10.5194/bg-18-1645-2021.

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Abstract. Trace elements (TEs) play important roles as micronutrients in modulating marine productivity in the global ocean. The South Atlantic around 40∘ S is a prominent region of high productivity and a transition zone between the nitrate-depleted subtropical gyre and the iron-limited Southern Ocean. However, the sources and fluxes of trace elements to this region remain unclear. In this study, the distribution of the naturally occurring radioisotope 228Ra in the water column of the South Atlantic (Cape Basin and Argentine Basin) has been investigated along a 40∘ S zonal transect to estimat

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22

Peters, Niamh, John Gaffney, Emma Connolly, et al. "Radium-223 in the treatment of metastatic castrate-resistant prostate cancer: A real-world Irish experience." Journal of Clinical Oncology 38, no. 6_suppl (2020): 228. http://dx.doi.org/10.1200/jco.2020.38.6_suppl.228.

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228 Background: Radium 223 (Ra-223) has been successfully utilised in the trial setting for the treatment of men with metastatic castrate resistant prostate cancer (mCRPC). To date, no real world outcomes from its use in the Irish population have been described. Methods: From September 2016 to March 2019, data from men referred for Ra-223 treatment at our institution was retrospectively collected. We recorded patient characteristics, treatments received and outcomes. Overall Survival (OS) was analysed using the Kaplan-Meier method. Results: 81 men were referred for Ra 223. Complete data was av

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23

Joshi, S. R. "Determination of Lead-210, Radium-226, Thorium-228 and Uranium-238 in Five CCRMP Reference Samples by Gamma-Ray Spectrometry." Geostandards and Geoanalytical Research 11, no. 2 (1987): 199–201. http://dx.doi.org/10.1111/j.1751-908x.1987.tb00028.x.

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24

Hakam, O. K., A. Choukri, J. L. Reyss, and M. Lferde. "Comparaison des activités des isotopes de l'uranium et du radium dans quelques échantillons d'eau de puits et de sources thermales au Maroc." Revue des sciences de l'eau 13, no. 2 (2005): 185–92. http://dx.doi.org/10.7202/705390ar.

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Les activités des isotopes de l'uranium et du radium (234U,238U,226Ra,228Ra) ainsi que les rapports d'activité (234U/238U,226Ra/238U,228 Ra/226Ra) ont été mesurés, pour la première fois au Maroc, dans 15 échantillons d'eau de puits et 12 échantillons d'eau de sources thermales. Les résultats obtenus montrent que, contrairement aux eaux de puits, les eaux des sources thermales présentent des activités de238U relativement faibles et des activités de226Ra et des rapports234U/238U élevés. Les activités de l'uranium et du radium mesurées sont comparables à celles que l'on trouve habituellement dans

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25

Sanial, V., L. E. Kipp, P. B. Henderson, et al. "Radium-228 as a tracer of dissolved trace element inputs from the Peruvian continental margin." Marine Chemistry 201 (April 2018): 20–34. http://dx.doi.org/10.1016/j.marchem.2017.05.008.

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26

Hammond, Douglas E., Richard A. Marton, Wiliam M. Berelson, and Teh-Lung Ku. "Radium 228 distribution and mixing in San Nicolas and San Pedro Basins, southern California Borderland." Journal of Geophysical Research 95, no. C3 (1990): 3321. http://dx.doi.org/10.1029/jc095ic03p03321.

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27

Reyss, Jean-Louis, Arnaud Mangeret, Christelle Courbet, et al. "Estimation of sedimentation rates based on the excess of radium 228 in granitic reservoir sediments." Journal of Environmental Radioactivity 162-163 (October 2016): 8–13. http://dx.doi.org/10.1016/j.jenvrad.2016.04.032.

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28

Santos Júnior, J. A., R. S. Amaral, C. M. Silva, R. S. C. Menezes, and J. D. Bezerra. "Radium-228 as an Indicator of Thorium-232 Presence in a Soil in Pernambuco, Brazil." Bulletin of Environmental Contamination and Toxicology 82, no. 6 (2009): 650–52. http://dx.doi.org/10.1007/s00128-009-9633-8.

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29

Cucoș, Alexandra Laura, Mircea Claudiu Moldovan, Bety Denissa Burghele, Tiberius Dicu, and Oana Teodora Moldovan. "Radiological Risk Assessment for Karstic Springs Used as Drinking Water in Rural Romania." Atmosphere 12, no. 9 (2021): 1207. http://dx.doi.org/10.3390/atmos12091207.

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Seasonal variations of the radon and radium activity concentrations in karstic water sources originating in karstic formations were investigated as part of a premiere systematic survey conducted in Romania. A database including a total of 228 drinking water samples collected from 30 distinct water sources adjacent to rural communities was compiled. The radon and radium activity concentrations for all seasons, assessed based on solid scintillation, ranged from 2.1 to 19.7 Bq/L and from 0.6 to 3.0 Bq/L, respectively. Overall, the detected radon and radium contents did not exceed the radioprotect

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30

Tomita, Jumpei, Jing Zhang, and Masayoshi Yamamoto. "Radium isotopes ( 226 Ra and 228 Ra) in Na–Cl type groundwaters from Tohoku District (Aomori, Akita and Yamagata Prefectures) in Japan." Journal of Environmental Radioactivity 137 (November 2014): 204–12. http://dx.doi.org/10.1016/j.jenvrad.2014.07.021.

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31

Nour, S., A. El-Sharkawy, W. C. Burnett, and E. P. Horwitz. "Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin." Applied Radiation and Isotopes 61, no. 6 (2004): 1173–78. http://dx.doi.org/10.1016/j.apradiso.2004.04.001.

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32

Charette, Matthew A., Phoebe J. Lam, Maeve C. Lohan, et al. "Coastal ocean and shelf-sea biogeochemical cycling of trace elements and isotopes: lessons learned from GEOTRACES." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 374, no. 2081 (2016): 20160076. http://dx.doi.org/10.1098/rsta.2016.0076.

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Continental shelves and shelf seas play a central role in the global carbon cycle. However, their importance with respect to trace element and isotope (TEI) inputs to ocean basins is less well understood. Here, we present major findings on shelf TEI biogeochemistry from the GEOTRACES programme as well as a proof of concept for a new method to estimate shelf TEI fluxes. The case studies focus on advances in our understanding of TEI cycling in the Arctic, transformations within a major river estuary (Amazon), shelf sediment micronutrient fluxes and basin-scale estimates of submarine groundwater

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33

Mears, Chantal, Helmuth Thomas, Paul B. Henderson, et al. "Using <sup>226</sup>Ra and <sup>228</sup>Ra isotopes to distinguish water mass distribution in the Canadian Arctic Archipelago." Biogeosciences 17, no. 20 (2020): 4937–59. http://dx.doi.org/10.5194/bg-17-4937-2020.

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Abstract. As a shelf-dominated basin, the Arctic Ocean and its biogeochemistry are heavily influenced by continental and riverine sources. Radium isotopes (226Ra, 228Ra, 224Ra, and 223Ra), are transferred from the sediments to seawater, making them ideal tracers of sediment–water exchange processes and ocean mixing. As the two long-lived isotopes of the radium quartet, 226Ra and 228Ra (226Ra with a t1∕2 of 1600 years and 228Ra with a t1∕2 of 5.8 years) can provide insight into the water mass compositions, distribution patterns, as well as mixing processes and their associated timescales throug

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34

Le Gland, Guillaume, Laurent Mémery, Olivier Aumont, and Laure Resplandy. "Improving the inverse modeling of a trace isotope: how precisely can radium-228 fluxes toward the ocean and submarine groundwater discharge be estimated?" Biogeosciences 14, no. 13 (2017): 3171–89. http://dx.doi.org/10.5194/bg-14-3171-2017.

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Abstract. Radium-228 (228Ra), an almost conservative trace isotope in the ocean, supplied from the continental shelves and removed by a known radioactive decay (T1∕2 = 5. 75 years), can be used as a proxy to constrain shelf fluxes of other trace elements, such as nutrients, iron, or rare earth elements. In this study, we perform inverse modeling of a global 228Ra dataset (including GEOSECS, TTO and GEOTRACES programs, and, for the first time, data from the Arctic and around the Kerguelen Islands) to compute the total 228Ra fluxes toward the ocean, using the ocean circulation obtained from the

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35

Nozaki, Yoshiyuki, and Yoshiyuki Yamamoto. "Radium 228 based nitrate fluxes in the eastern Indian Ocean and the South China Sea and a silicon-induced “alkalinity pump” hypothesis." Global Biogeochemical Cycles 15, no. 3 (2001): 555–67. http://dx.doi.org/10.1029/2000gb001309.

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36

Charette, M. A., C. F. Breier, P. B. Henderson, et al. "Radium-based estimates of cesium isotope transport and total direct ocean discharges from the Fukushima Nuclear Power Plant accident." Biogeosciences 10, no. 3 (2013): 2159–67. http://dx.doi.org/10.5194/bg-10-2159-2013.

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Abstract. Radium has four naturally occurring isotopes that have proven useful in constraining water mass source, age, and mixing rates in the coastal and open ocean. In this study, we used radium isotopes to determine the fate and flux of runoff-derived cesium from the Fukushima Dai-ichi Nuclear Power Plant (FNPP). During a June 2011 cruise, the highest cesium (Cs) concentrations were found along the eastern shelf of northern Japan, from Fukushima south, to the edge of the Kuroshio Current, and in an eddy ~ 130 km from the FNPP site. Locations with the highest cesium also had some of the high

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37

Charette, M. A., C. F. Breier, P. B. Henderson, et al. "Radium-based estimates of cesium isotope transport and total direct ocean discharges from the Fukushima Nuclear Power Plant accident." Biogeosciences Discussions 9, no. 11 (2012): 16139–60. http://dx.doi.org/10.5194/bgd-9-16139-2012.

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Abstract. Radium has four naturally occurring isotopes that have proven useful in constraining water mass source, age, and mixing rates in the coastal and open ocean. In this study, we used radium isotopes to determine the fate and flux of runoff-derived cesium from the Fukushima Nuclear Power Plant (NPP). During a June 2011 cruise, the highest Cs concentrations were found along the eastern shelf of northern Japan, from Fukushima south, to the edge of the Kuroshio current, and in an eddy ∼ 130 km from the NPP site. Locations with the highest cesium also had some of the highest radium activitie

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38

Fayyadh, Ahmed Hameed, and Anmar Dherar Kosaj. "Estimation of Radionuclide Concentration in Medical Waste." Materials Science Forum 1021 (February 2021): 191–99. http://dx.doi.org/10.4028/www.scientific.net/msf.1021.191.

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Almost all hospitals use radioisotopes for different purposes, as their applications grow, so their concentration in the waste of those hospitals does. To address this issue, twenty-nine samples were collected from (9) sites, these samples were collected from the incinerators of medical areas and the waste collection chambers. After collecting the samples, they were prepared for the examination, where a high-purity Germanium detector (HPGe) was used to detect radioactive elements. The lead element (Pb-214) of the uranium chain (U-238) and the actinium element (Ac-228), the lead element (Pb-212

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39

Missimer, Thomas M., Christopher Teaf, Robert G. Maliva, Ashley Danley-Thomson, Douglas Covert, and Michael Hegy. "Natural Radiation in the Rocks, Soils, and Groundwater of Southern Florida with a Discussion on Potential Health Impacts." International Journal of Environmental Research and Public Health 16, no. 10 (2019): 1793. http://dx.doi.org/10.3390/ijerph16101793.

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Southern Florida is underlain by rocks and sediments that naturally contain radioactive isotopes. The primary origin of the radioactive isotopes is Miocene-aged phosphate deposits that can be enriched in uranium-238 and its daughter isotopes. Nodular phosphate containing radionuclides from the Miocene has been reworked into younger formations and is ubiquitous in southern Florida. When the nodular phosphate is exposed to groundwater with geochemical conditions favorable for its dissolution, uranium, radium, and radon may be released into the groundwater system. Uranium concentrations have been

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40

Girault, Frédéric, Frédéric Perrier, and Tadeusz A. Przylibski. "Radon-222 and radium-226 occurrence in water: a review." Geological Society, London, Special Publications 451, no. 1 (2016): 131–54. http://dx.doi.org/10.1144/sp451.3.

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41

Abou, Diane S., Juile Pickett, John E. Mattson, and Daniel L. J. Thorek. "A Radium-223 microgenerator from cyclotron-produced trace Actinium-227." Applied Radiation and Isotopes 119 (January 2017): 36–42. http://dx.doi.org/10.1016/j.apradiso.2016.10.015.

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42

Kani, Kimia Khalatbari, Hyojeong Mulcahy, and Felix S. Chew. "Case 228." Radiology 277, no. 3 (2015): 913–15. http://dx.doi.org/10.1148/radiol.2015132279.

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43

Al-Masri, Mohammad Said, Jamal Al Abdullah, Yusr Amin, et al. "Separation of actinium-227 and its daughter radium-223 from phosphogypsum." Journal of Radioanalytical and Nuclear Chemistry 325, no. 2 (2020): 463–70. http://dx.doi.org/10.1007/s10967-020-07251-0.

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44

Pinto, Álvaro, and Patricia Cruz. "Radium-223 Chloride." Drugs in R&D 12, no. 4 (2012): 227–33. http://dx.doi.org/10.2165/11636250-000000000-00000.

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45

McGann, Shane, and Evan R. Horton. "Radium-223 Dichloride." Annals of Pharmacotherapy 49, no. 4 (2015): 469–76. http://dx.doi.org/10.1177/1060028014565444.

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46

Herbolsheimer, M. "Radium-223-Dichlorid." Der Onkologe 20, no. 10 (2014): 1024–26. http://dx.doi.org/10.1007/s00761-014-2787-y.

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47

Larsson, Erik, Gustav Brolin, Adriaan Cleton, Tomas Ohlsson, Ola Lindén, and Cecilia Hindorf. "Feasibility of Thorium-227/Radium-223 Gamma-Camera Imaging During Radionuclide Therapy." Cancer Biotherapy and Radiopharmaceuticals 35, no. 7 (2020): 540–48. http://dx.doi.org/10.1089/cbr.2019.3516.

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48

Song, Lijuan, Yonggang Yang, Maoyi Luo, Yan Ma, and Xiongxin Dai. "Rapid determination of radium-224/226 in seawater sample by alpha spectrometry." Journal of Environmental Radioactivity 171 (May 2017): 169–75. http://dx.doi.org/10.1016/j.jenvrad.2017.01.024.

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49

Dzhuzha, D., and S. Myasoyedov. "Radionuclide therapy with alpha-emitters." Radiation Diagnostics, Radiation Therapy, no. 4 (2019): 37–47. http://dx.doi.org/10.37336/2707-0700-2019-4-4.

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In this review the main streams of using alpha-emitters radium-223, actinium-225, bismuth-213, astatine-211 in complex treatment of malignant tumors are reviewed. The features of radiobiological actions of alpha-emission make its more effective in hundred times than beta-emission. The efficacy of this kind of radionuclide therapy does not dependent from chemoresistance and radioresistance to beta-emitters. The results of experimental and initial clinical investigation, which indicate on promising further investigations in this direction, were revealed. Key words: radionuclide therapy of malign

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50

Zhao, Hanson Hanqing, Lauren Howard, Amanda de Hoedt, et al. "Radium-223 treatment patterns in a large real-world population." Journal of Clinical Oncology 37, no. 7_suppl (2019): 190. http://dx.doi.org/10.1200/jco.2019.37.7_suppl.190.

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190 Background: For men with symptomatic metastatic castration resistant prostate cancer (mCRPC), radium-223 was shown to improve overall survival in the phase III, double blind ALSYMPCA trial. Despite the observed benefits, the application and practice patterns of Radium-223 outside of clinical trials are largely unknown. Here we aim to better characterize the use of radium-223 in a large and heterogeneous real-world population. We identify treatment patterns associated with radium-223 and link these patterns with time to skeletal related event (SRE) and mortality. Methods: We reviewed charts

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