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Dissertations / Theses on the topic 'RAG Model'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Tanner, Anne. "Human Herpesvirus 6A Infection and Immunopathogenesis in Humanized Rag2^-/-γc-/- Mice and Relevance to HIV/AIDS and Autoimmunity". BYU ScholarsArchive, 2016. https://scholarsarchive.byu.edu/etd/6078.

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Human herpesvirus 6A (HHV-6A) has yet to be definitively linked to a specific disease. This is due in part to the ubiquitous nature of the virus. Humanized Rag2-/-γc-/- (Rag-hu) mice were tested to determine if these were a suitable animal model to study the virus. Both cell-free and cell-associated virus was used for infection and both were found to be efficient at infecting the mice. Viral DNA was found in the plasma and cellular blood fractions, bone marrow, lymph node, and thymus, indicating successful infection and propagation of the virus in vivo. The CD3+CD4- population was depleted, wh

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2

Kanellopoulou, Chrysi. "Analysis of locus accessibility for V(D)J recombination and its potential in generating a mouse model for monitoring RAG protein expression in peripheral B cells." [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=965433579.

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3

O, H.-Ici Darach Michael. "Multi-modal imaging of myocardial ischemia and reperfusion in a rat model." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/multimodal-imaging-of-myocardial-ischemia-and-reperfusion-in-a-rat-model(43bf5945-ce02-48cc-a634-2ebf00cffc99).html.

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Myocardial ischaemia causes progressive cellular injury. Initially there is loss of function, followed by formation of oedema. Ischemia, if prolonged, will eventually lead to cell death. Revascularisation of occluded coronary arteries is an efficient tool to reduce infarct size in acute myocardial infarction. However, reperfusion in itself can be associated with a significant amount of myocardial damage. The structural and metabolic changes occurring in myocardial ischemia and reperfusion can now be studied in-vivo using magnetic resonance imaging (MRI) and are targets to optimise the treatmen

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4

Henzler, Thomas. "Visible-Rat-Model: ein digitales anatomisches Muskel-Knochen-Modell der hinteren Extremität der Ratte." [S.l. : s.n.], 2007. http://nbn-resolving.de/urn:nbn:de:bsz:289-vts-60581.

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5

Acheampong, Josephine. "Green Financing: Financing Circular Economy Companies : Case Studies of Ragn-Sellsföretagen AB and Inrego AB." Thesis, KTH, Entreprenörskap och Innovation, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-188677.

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The circular economy (CE) has been identified as a catalyst in sustainable development and economic growth that has the potential to move society from the traditional linear model of resource consumption in the form of take-make-waste to an innovative circular model in the form of reduce-reuse-recycle. Transitioning from the linear economy to the CE requires changes in four areas: material and product design, business models, global reverse networks and enabling business environments. This study considers the financing needs of CE companies as a result of business model changes. Through the ca

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6

Kompil, Mert Çelik H. Murat. "Modeling retail structural change of İzmir using a dynamic spatial interaction model/." [s.l.]: [s.n.], 2004. http://library.iyte.edu.tr/tezler/master/sehirplanlama/T000469.rar.

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7

Roženský, Mário. "Minimalistický objektově orientovaný "ray tracer"." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2008. http://www.nusl.cz/ntk/nusl-235869.

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This thesis brings an overview about scene rendering using the ray tracing method. It describes aspects used when creating the application which uses this method such as intersection computation, lighting and shading models etc. It also describes the basic algorithm used for rendering one frame. Each class of the object oriented design is described. There is also detail explanation what is the purpose of the each class in the model and what are the most important used methods. The work also contains demonstration application showing the usage of model in practice.

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8

Lebovitz, Marc A. (Marc Adam) 1975. "A prediction model for ray tracing." Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/80095.

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Thesis (M.Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, June 1999.<br>Includes bibliographical references (leaf 86).<br>by Marc A. Lebovitz.<br>M.Eng.

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9

Felix, Francisco HÃlder Cavalcante. "Rat brain Walker tumor implantation model." Universidade Federal do CearÃ, 2001. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=34.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>The disabling effects of central nervous system (CNS) tumors are out of proportion to their low incidence. Theyâre second only to stroke as neurologic mortality causes. Brain metastases are the commonest intracranial tumors in adults, almost 10 times more frequent than primary brain tumors. Their diagnosis and treatment have met significant advances, although much more research about drug resistance and new treatment modalities are needed. New and even better brain tu

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10

Xiao, Feipeng. "Development of fatigue predictive models of rubberized asphalt concrete (RAC) containing reclaimed asphalt pavement (RAP) mixtures." Connect to this title online, 2006. http://etd.lib.clemson.edu/documents/1171902609/.

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11

Wang, Joe. "A study of the effects of Ki-Ras inhibition by antisense deoxyoligonucleotides in a rat model of renal fibrosis." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/a-study-of-the-effects-of-kiras-inhibition-by-antisense-deoxyoligonucleotides-in-a-rat-model-of-renal-fibrosis(7d0caa23-6557-4964-a573-9849de52fb38).html.

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Ras monomeric GTPases are key molecules in the signalling pathway of renal fibrogenesis and exist in three isoforms (Kirsten, Harvey and Neural). The aim of this thesis was to determine whether inhibition of Ki-Ras expression by ASOs could ameliorate the process of renal fibrosis. All isoforms of Ras were expressed in rat renal fibroblasts (primary culture and cell line (NRK-49F)) and in a rat epithelial cell line (NRK-52E). In vitro administration of Ki-Ras ASOs resulted in a specific knockdown of the isoform mRNA in all cells. An associated rise in Ha-Ras mRNA was noted in fibroblast cells b

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12

Islam, Atiqul. "The adrenalectomized rat : a model for neurodegeneration /." Stockholm, 1997. http://diss.kib.ki.se/1997/91-628-2667-0.

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13

Pupim, Pedro Henrique Freitas. "Modelos de propagação de vazão aplicados ao rio Tocantins - comparação entre HEC-RAS e Muskingum-Cunge-Todini /." Ilha Solteira, 2017. http://hdl.handle.net/11449/180929.

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Orientador: Jefferson Nascimento de Oliveira<br>Resumo: O estudo do comportamento de corpos hídricos propicia a obtenção de informações relevantes à bacia hidrográfica e ao meio pertencente a ela, resultando em diversos benefícios, não só do ponto de vista econômico, onde através de operação otimizada de reservatórios de água pode-se obter um maior aproveitamento para geração de energia hidrelétrica, abastecimento, irrigação ou outros fins, mas também subsidia o planejamento e a tomada de decisões com a relação à mitigação de riscos hidrodinâmicos, como o mapeamento de zonas potencialmente inu

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14

Agnarsson, Joakim. "Simulation of a radar in Flames : a ray based radar model." Thesis, Uppsala universitet, Institutionen för informationsteknologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-201093.

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In this report a radar model is modeled and implemented in a simulation framework called Flames. The focus is to investigate how and if electromagnetic waves emitted from the radar antenna can be simulated by different methods and how these methods can be implemented to work in real-time simulations. The radar model developed in this report is based on ray tracing and ray propagation techniques developed by the author. The model considers varying refractive indices that describes both standard atmospheres and atmospheres where ducting occur. Preparatory studies are also made to model ground re

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15

Arthur, M. J. P. "Functional studies of purified rat hepatic macrophages." Thesis, University of Southampton, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374057.

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16

Hishida, Masashi, Kazuhiro Toriyama, Yoriko Yamashita, et al. "Omental Flap Closure of Refractory Wounds: Rat Model." Nagoya University School of Medicine, 2010. http://hdl.handle.net/2237/12913.

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17

Nangunoori, Chetan Kumar, and Bhaskar Ravichandra Kumar Kumar. "Parametric Ram Air Channel Model for Flow Optimization." Thesis, Linköpings universitet, Fluida och mekatroniska system, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-80069.

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Ram air channel or NACA channel is used to direct the ambient air for various purposes in an aircraft, such as pressurizing the cabin or as a coolant to heat exchangers and even more other applications like a cooling of the coolant. It is designed; such that it supplies the required amount of ambient air for various operations as mentioned, even aero-dynamical features should be taken into consideration while designing. In past, the developed prototypes are to be designed first and then experimented to optimize the design which gives accurate predictions and makes easy to understand the phenom

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18

Yang, Liqun. "Excitotoxic model of posttraumatic syringomyelia in the rat." Title page, contents and abstract only, 1999. http://web4.library.adelaide.edu.au/theses/09MS/09msy22.pdf.

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Bibliography: leaves 112-127. Study using an animal model (Sprague-Dawley rats) to elucidate the role of EAAs and spinal subarachnoid blockade in posttraumatic syringomelia. Results support the proposal that in posttraumatic spinal cord injury, primary injury and exitotoxic cell death, occuring secondary to elevated levels of EAAs, contribute to a pathologic process leading to the formation of spinal cavities, and a subarachnoid block by arachnoiditis is one of the pathogenic factors most responsible for initiating extension of the cavity.

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19

Arp, Jacqueline. "HTLV-I vaccine design and rat challenge model." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq21276.pdf.

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20

Ajanusi, Joseph O. "Immunochemistry of Fasciola hepatica in the rat model." Thesis, University of Edinburgh, 1994. http://hdl.handle.net/1842/30081.

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The excretions, secretions and surface components of a parasite are by their nature centrally involved in the host/parasite interaction. Rats, like cattle, are capable of developing resistance to fasciolosis after primary infection and are therefore considered a suitable laboratory model for cattle. The objective of this study was to characterise the excretory/secretory (ES) and surface components of <I>Fasciola hepatica</I> as it develops in the rat, and to identify those components involved in the host/parasite interaction that may have diagnostic and/or protective value. Three trials were c

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21

Medin, Zach, Marina von Steinkirch, Alan C. Calder, Christopher J. Fontes, Chris L. Fryer, and Aimee L. Hungerford. "MODEL ATMOSPHERES FOR X-RAY BURSTING NEUTRON STARS." IOP PUBLISHING LTD, 2016. http://hdl.handle.net/10150/624031.

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The hydrogen and helium accreted by X-ray bursting neutron stars is periodically consumed in runaway thermonuclear reactions that cause the entire surface to glow brightly in X-rays for a few seconds. With models of the emission, the mass and radius of the neutron star can be inferred from the observations. By simultaneously probing neutron star masses and radii, X-ray bursts (XRBs) are one of the strongest diagnostics of the nature of matter at extremely high densities. Accurate determinations of these parameters are difficult, however, due to the highly non-ideal nature of the atmospheres wh

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22

Hawkins, C. A. "Some studies on an animal model of temporal lobe epilepsy." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375246.

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23

Lima, Adriano Dawison de [UNESP]. "Otimização do aproveitamento do palhiço da cana-de-açucar." Universidade Estadual Paulista (UNESP), 2009. http://hdl.handle.net/11449/101686.

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Made available in DSpace on 2014-06-11T19:31:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-09-18Bitstream added on 2014-06-13T18:42:19Z : No. of bitstreams: 1 lima_ad_dr_botfca.pdf: 724130 bytes, checksum: 15034f5abe44917d0dddf94bf8ba9585 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>A energia tornou-se um fator determinante do desempenho das empresas, caracterizando-se como uma fonte potencial de vantagem competitiva, a qual tem contribuído de forma significativa para a estrutura de custos. Nos últimos anos, as empresas sucroalcooleiras estão co

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24

Oiso, Yutaka, Hiroshi Nagasaki, and Hisashi Yokoi. "Transgenic rat models of vasopressin overexpression." Nagoya University School of Medicine, 2003. http://hdl.handle.net/2237/5393.

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25

Si-Hoe, San Ling. "The utility of transgenic rat models." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325801.

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26

Caviness, James A. "Stress biomarkers in a rat model of decompression sickness /." Download the thesis in PDF, 2005. http://www.lrc.usuhs.mil/dissertations/pdf/Caviness2005.pdf/.

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27

Lau, Hoi-shan Flora. "Retinal ganglion cells vulnerability in a rat glaucoma model /." View the Table of Contents & Abstract, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31495217.

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28

Morrison, Ryan G. "The Zucker rat as a model of obesity-hypertension." Huntington, WV : [Marshall University Libraries], 2006. http://www.marshall.edu/etd/descript.asp?ref=638.

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Theses (Ph. D.)--Marshall University, 2006.<br>Title from document title page. Includes abstract. Document formatted into pages: contains xiii, 138 p. including illustrations. Bibliography: p. 109-121.

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29

Baker, K. Adam. "Neural transplantation in the rat model of Parkinson's disease." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0021/MQ57270.pdf.

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30

Simmerman, Neil. "The rat as a model of female sexual arousal /." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33446.

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Female Sexual Dysfunction (FSD) is a significant problem affecting 25%--63% women in the U.S. alone. Although the research community has begun to increase efforts to understand FSD, there is a lack of an animal model in which this condition can be studied. The current research provides data for a new model of sexual arousal in the female Sprague-Dawley rat. The vascular effects in the clitoris and vagina in response to clitoral and pelvic plexus nerve stimulations were studied. Modulation of these effects by infusion of Nitric Oxide, Vasoactive Intestinal Peptide and Calcitonin-Gene Related Pe

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31

Niederer, Steven Alexander. "A coupled electromechanics model of the rat left ventricle." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497058.

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32

Lai, Ka-wai, and 黎嘉慧. "A rat model to study ovarian dysfunction in galactosemia." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B29749037.

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33

Lau, Hoi-shan Flora, and 劉凱珊. "Retinal ganglion cells vulnerability in a rat glaucoma model." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B45010250.

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34

Zhang, Endong, and 张恩东. "Beneficial effects of lycium barbarum in rat depression model." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46477111.

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35

Woo, Tak-yunn Tiffany, and 胡德欣. "Neuroprotective strategies in a rat model of retinal detachment." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48334911.

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Retinal detachment (RD) is a leading cause of blindness and although final surgical reattachment rate has greatly improved, visual outcome in many macula-off detachments is disappointing, mainly because of photoreceptor cell death. We previously showed that both lutein and Lycium barbarum polysaccharides (LBP) are neuroprotective in a rodent model of ischemia/reperfusion injury. The objective of this study is to investigate lutein and LBP as possible pharmacological adjuncts to surgery. Lutein: Subretinal injections of 1.4% sodium hyaluronate were used to induce RD in Sprague-Dawley rats

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36

Tweedle, Valerie. "Simulation Model of Ray Patterning in Zebrafish Caudal Fins." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23181.

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The bony fin rays of the zebrafish caudal fin are a convenient system for studying bone morphogenesis and patterning. Joints and bifurcations in fin rays follow predictable spatial patterns, though the mechanisms underlying these patterns are not well understood. We developed simulation models to explore ray pattern formation mechanisms in growing fins. In all models, the fin ray growth rates are based on quantitative experimental data. The different models simulate ray joint formation and bifurcation formation using different hypothetical mechanisms. In the most plausible model, ray joint and

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37

Vinen, Catherine Susanna. "Immunoregulation in the Brown Norway Rat model of vasculitis." Thesis, St George's, University of London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.412333.

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38

Parker, V. M. "The socially isolated rat as a model of anxiety." Thesis, University of Surrey, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382934.

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39

Figueiredo, Francisco Carlos D'Amorim de. "Immunopathology of corneal graft rejection in a rat model." Thesis, University of Bristol, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296671.

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40

Hindmarsh, Andrew. "Chemoprevention in a validated rat model of oesophageal adenocarcinoma." Thesis, Queen Mary, University of London, 2012. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8826.

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The UK has experienced an increase in the incidence of oesophageal adenocarcinoma (OAC) in recent years. The prognosis for patients with OAC remains poor with currently available treatments prompting a search for alternative ‘chemopreventive’ treatments that inhibit oesophageal carcinogenesis. Both non-steroidal anti-inflammatory drugs (NSAIDS) and flavonoids are associated with a significant risk reduction for developing OAC in epidemiological studies. The aim of this study was to validate Levrat’s surgical model of OAC in the rat, and assess the chemopreventive effects of the NSAID aspirin,

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41

Kok, Wai Ling. "Characterisation of a rat model of post-herpetic neuralgia." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/29838.

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An <i>in vivo </i>model of latent VZV was developed in the adult rat by subcutaneous injection of VZV infected cells into the left footpad. Foot reflex withdrawal responses were recorded for longer than 60 days post infection similar to changes seen in PHN patients. The aim of this study was to further characterise this model so that it could provide a useful and unique opportunity to study the host-virus interaction involved in the pathogenesis of PHN. Nested PCR was able to detect viral DNA in the different lumbar DRG. Viral DNA was present in the infected DRG as early as 24 h post infection

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42

Shamsaldeen, Yousif. "Endothelial TRPV4 dysfunction in a streptozotocin-diabetic Rat Model." Thesis, University of Hertfordshire, 2016. http://hdl.handle.net/2299/17622.

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Diabetes mellitus is a complex disease characterised by chronic hyperglycaemia due to compromised insulin synthesis and secretion, or decreased tissue sensitivity to insulin, if not all three conditions. Endothelial dysfunction is a common complication in diabetes in which endothelium-dependent vasodilation is impaired. The aim of this study was to examine the involvement of TRPV4 in diabetes endothelial dysfunction. Male Charles River Wistar rats (350-450 g) were injected with 65mg/kg streptozotocin (STZ) intraperitoneally. STZ-injected rats were compared with naïve rats (not injected with S

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43

Thomas, Sean Casey. "A Developed and Characterized Orthotopic Rat Glioblastoma Multiforme Model." Thesis, Virginia Tech, 2020. http://hdl.handle.net/10919/100772.

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This thesis project serves to fill experimental gaps needed to advance the goal of performing pre-clinical trials using an orthotopic rat glioblastoma model to evaluate the efficacy of high-frequency electroporation (H-FIRE) and QUAD-CTX tumor receptor-targeted cytotoxic conjugate therapies, individually and in combination, in selectively and thoroughly treating glioblastoma multiforme. In order to achieve this, an appropriate model must be developed and characterized. I have transduced F98 rat glioma cells to express red-shifted firefly luciferase, which will facilitate longitudinal tumor mon

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44

Nishida, Ryuichi. "Endoscopic Sclerotherapy in a Rat Model of Esophageal Varices." Kyoto University, 1999. http://hdl.handle.net/2433/182286.

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Lai, Ka-wai. "A rat model to study ovarian dysfunction in galactosemia /." Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk:8888/cgi-bin/hkuto%5Ftoc%5Fpdf?B23295326.

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46

Connolly, Ashley Rex. "Cytokine gene expression in a rat model of polyarthritis /." Title page, contents and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09phc75238.pdf.

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47

Hijazi, Basel, and Gustav Åkesson. "Optimal selection of raw grain for ethanol production at Lantmännen Agroetanol." Thesis, Linköpings universitet, Kommunikations- och transportsystem, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-178107.

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Lantmännen is a Swedish agricultural cooperative in agriculture, machinery, bioenergy and food. With over 10,000 employees and 5 divisions, Lantmännen is the Nordic region’s largest ethanol manufacturer. In the Energy division business area are Agroetanol, which produces sustainable ethanol that is used for, among other things, biofuels. To produce ethanol, grains such as wheat, barley, triticale, corn and rye are mixed. The grain is purchased through forward contracts for up to a year before it is used in production. Depending on which mixture of grain is used, the amount of ethanol that is p

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48

Santos, Kamila Almeida dos. "Utilização de modelo hidrodinâmico para mapeamento de áreas inundáveis." Universidade Federal de Goiás, 2015. http://repositorio.bc.ufg.br/tede/handle/tede/5155.

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Wu, Hsiao-Chi David 1967. "Gene mutations in experimental models of carcinogenesis and their effects on responses to chemopreventive agents in the azoxymethane-treated rat model." Diss., The University of Arizona, 1997. http://hdl.handle.net/10150/282340.

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The Ki-ras oncogene and the p53 tumor suppressor gene are mutated in a high percentage of human colon cancers. The mutation status of these two genes were assessed in colon adenocarcinomas obtained from azoxymethane (AOM)- and dimethylhydrazine (DMH)-treated rats, widely used experimental models of human colon carcinogenesis. The status of p53 mutations was examined using polymerase chain reaction (PCR) amplification of these sequences. In so doing, it was discovered that the rat p53 gene is structurally distinct from the human p53 gene, since it is missing one intron between exons 6 and 7. Fu

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50

Chan, Ho-yin. "Simulation model for the time delay and broadening of gamma ray bursts /." Hong Kong : University of Hong Kong, 1995. http://sunzi.lib.hku.hk/hkuto/record.jsp?B14709107.

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